10 results on '"Abad, Kashif"'
Search Results
2. Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis
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Unruh, Mark, Cukor, Daniel, Rue, Tessa, Abad, Kashif, Roumelioti, Maria-Eleni, McCurry, Susan M., Heagerty, Patrick, and Mehrotra, Rajnish
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- 2020
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3. Chronic Kidney Disease
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Abad, Kashif and Unruh, Mark
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- 2021
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4. Chronic Kidney Disease
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Abad, Kashif and Unruh, Mark
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- 2020
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5. A Unique Case of Metformin-associated Severe Lactic Acidosis Without Preexisting Renal Disease: Perspectives on Prolonged Dialysis and Education for Prevention
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Abad, Kashif, primary, Kien, Cassandra, additional, and Ganta, Kavitha, additional
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- 2020
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6. Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice
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Ileana Ruxandra Botusan, Vivekananda Gupta Sunkari, Sergiu-Bogdan Catrina, Kerstin Brismar, Abad Kashif, Folke Lind, Omaida C. Velazquez, Seppo Ylä-Herttuala, and Zhao-Jun Liu
- Subjects
medicine.diagnostic_test ,business.industry ,Dermatology ,Neovascularization ,Real-time polymerase chain reaction ,medicine.anatomical_structure ,Western blot ,Mechanism of action ,Immunology ,medicine ,Cancer research ,Surgery ,Bone marrow ,medicine.symptom ,Progenitor cell ,Fibroblast ,business ,Wound healing - Abstract
Hyperbaric oxygen (HBO) therapy has been used as an adjunctive therapy for diabetic foot ulcers, although its mechanism of action is not completely understood. Recently, it has been shown that HBO mobilizes the endothelial progenitor cells (EPCs) from bone marrow that eventually will aggregate in the wound. However, the gathering of the EPCs in diabetic wounds is impaired because of the decreased levels of local stromal-derived factor-1α (SDF-1α). Therefore, we investigated the influence of HBO on hypoxia-inducible factor 1 (HIF-1), which is a central regulator of SDF-1α and is down-regulated in diabetic wounds. The effects of HBO on HIF-1α function were studied in human dermal fibroblasts, SKRC7 cells, and HIF-1α knock-out and wild-type mouse embryonic fibroblasts using appropriate techniques (Western blot, quantitative polymerase chain reaction, and luciferase hypoxia-responsive element reporter assay). Cellular proliferation was assessed using H(3) -thymidine incorporation assay. The effect of HIF in combination with HBOT was tested by inoculating stable HIF-1α-expressing adenovirus (Adv-HIF) into experimental wounds in db/db mice exposed to HBO. HBO activates HIF-1α at several levels by increasing both HIF-1α stability (by a non-canonical mechanism) and activity (as shown both by induction of relevant target genes and by a specific reporter assay). HIF-1α induction has important biological relevance because the induction of fibroblast proliferation in HBO disappears when HIF-1α is knocked down. Moreover, the local transfer of stable HIF-1α-expressing adenovirus (Adv-HIF) into experimental wounds in diabetic (db/db mice) animals has an additive effect on HBO-mediated improvements in wound healing. In conclusion, HBO stabilizes and activates HIF-1, which contributes to increased cellular proliferation. In diabetic animals, the local transfer of active HIF further improves the effects of HBO on wound healing.
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- 2015
7. Contributors
- Author
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Abad, Kashif, Abdul-Hussein, Mustafa, Adam, Rodney D., Adams, Paul C., Agudelo Higuita, Nelson Iván, Akst, Lee, Anderson, Kelley P., Andre, Paul, Anstead, Gregory M., Aring, Ann M., Arshi, Arash, Avalos, Danny, Azar, Cecilio M., Azarbal, Amir, Baeseman, Zachary J., Bailey, Justin, Bajaj, Mandeep, Bakhutashvili, Vladimer, Balagué, Federico, Barth, Bradley E., Basello, Gina M., Bassaly, Renee M., Bassily-Marcus, Adel, Baughn, Julie M., Beard, Sheryl, Belakovskiy, Aleksandr, Ben-Ami, Ronen, Bencheqroun, Hassan, Bernstein, David I., Bernstein, Jonathan A., Biggerstaff, Kristin Schmid, Birt, Mitchell, Bloomfield, Clara, Blum, William, Bolotin, Diana, Bonnema, Rachel A., Borenstein, David, Bossart, Christopher, Bragg, Dee Ann, Bragg, Scott, Bremjit, Prasheda, Brice, Sylvia L., Brill, John, Brown, Patricia D., Brown, Patrick, Brown, Rachel, Buckley, Peter F., Burns, Sarah, Byrd, Kenneth, Cadavid, Diego, Caraccio, Thomas R., Carek, Peter J., Carrion, Andres F., Cass, Amanda S., Castell, Donald O., Catinella, Anthony Peter, Cayley, William E., Jr., Cerquozzi, Sonia, Cervera, Alvaro, Chamberlain, Rachel, Chan, Lawrence, Chan, Miriam, Chang, Zenas, Chen, Jimmy, Chen, Lin Yee, Chihara, Shingo, Chitlur, Meera, Chohan, Saima, Christensen, Jacob, Chyu, Kuang-Yuh, Cigarroa, Joaquin E., Cleland, Paul, Cline, Matthew K., Coates, Laura C., Colenbrander, August, Collins, Tracie C., Commins, Ryan M., Conageski, Christine, Conly, John M., Contini, Carlo, Cooper, Ashley, Cormier, Allison K., Corriveau, Michael L., Cox, Bart L., Cunha, Burke A., Cunha, Cheston B., Curry, Amy E., Dai, Julia, Daines, Cori L., Damas, Oriana M., Damitz, Beth A., Dattilo, Natalie C., Davaro, Raul, David, Kevin A., de Leon, André, de Leon, Tate, DeCastro, Alexei O., DeGeorge, Katharine C., DeLoughery, Thomas G., Deodhar, Atul, Desai, Urmi, Dessinioti, Clio, Diamond, Michael P., Donnan, Geoffrey A., Dorsch, John N., Douglas, Chad, Dowler, Shannon, Drevets, Douglas A., Dudley, Samuel C., Jr., Duggan, Peter R., Eagle, Kim, Eck, Leigh M., Egnatios, Genevieve L., Atrouni, Wissam El, Elston, Dirk M., Embil, John M., Epstein, Scott K., Evans, Susan, Evens, Andrew M., Fagan, J. Barry, Faris, Anna, Faugno, Anthony J., III, Fayssoux, Kinder, Feldman, Dorianne, Fife, Terry D., Finley, David J., Firnhaber, Jonathon, Fisher, William E., Fleseriu, Maria, Fletcher, Donald C., Forsberg, Sarah, Foster, Jeffrey Michael, Frank, Jennifer, Freeman, Ellen W., Gaba, Ruchi, Gaines, Melissa, Ghany, Marc G., Ghazi, Muhammad Ahmad, Gibney, Geoffrey, Gilbert, Donald L., Gilchrist, Karissa, Gillaspie, Erin A., Gilotra, Tarvinder, Gladwin, Mark T., Gluckman, Stephen J., Goddard, Andrew W., Goerl, Kyle, Gold, Mark S., Goldstein, Joshua N., González-Fernández, Marlis, Goodwin, Gregory, Gosmanov, Aidar R., Gradoni, Luigi, Graham, Timothy P., Grant-Kels, Jane M., Grdinovac, Kristine, Greenberg, Leslie A., Greene, William M., Greensher, Joseph, Gregory, David S., Greiwe, Justin, Gumbo, Tawanda, Hague, Melissa, Halder, Rebat M., Hall, Alan M., Hall, Ronald, II, Harman, Lynn E., Harris, Kari R., Harrison, Taylor B., Hartman, Adam L., Haynes, James W., Heidelbaugh, Joel J., Hinderliter, Stacey A., Hinshaw, Molly A., Hockenberry, Brandon, Hohl, Raymond J., Holguin, Therese, Holstein, Sarah A., Holyoak, Michael, Homan, Gretchen, Hommema, Kevin, Hommema, Laurie A.M., Horn, Leora, Hossani-Madani, Ahmad Reza, House, Steven A., Houssayni, Sarah, Hueston, William J., Huffstetler, Alison N., Hundahl, Scott A., Hunger, Stephen P., Irwin, Gretchen M., Isaac, Daniel, Isenberg, Gerald A., Jackson, Alan C., Jacobson, Kurt M., Jaller, Jose A., James, W. Ennis, Jia, Xiaoming, Johnson, Casey R., Johnson, Lisa M., Jolissaint, Joshua S., Juckett, R. Gregory, Judson, Marc A., Kadhiravan, Tamilarasu, Kalia, Rachna, Rachel Kanter, Jessica, Karnad, Dilip R., Karnchanasorn, Rudruidee, Katsambas, Andreas, Katz, Ben Z., Katzman, Rebecca, Kaufer, Daniel I., Kaunitz, Andrew M., Keegan, B. Mark, Kellerman, Rick D., Kellermann, Scott, Kelly, Christina M., Khaki, Sheevaun, Kim, Arthur Y., Kim, Haejin, Kirsner, Robert S., Kiwalkar, Sonam, Kolb, Amanda, Kolla, Bhanu Prakash, Korley, Frederick K., Kovalsky, Adrienne N., Krause, Megan, Kraut, Eric H., Krishnamurti, Lakshmanan, Krishnan, Kumar, Kuhlmann, Zachary, Kulkarni, Roshni, Kumar, Seema, Kwaan, Mary R., Kyle, Robert A., Lampton, Lucius Marion, Lange, Richard A., Langlois, Fabienne, Larkin, Jerome, Lau, Christine L., Lawrence-Hylland, Susan, Lee, Lydia U., Leikin, Jerrold B., Leikin, Scott, Leung, Alexander K.C., LeWinter, Martin M., Lewis, Jennifer, Li, Ming, Liebenstein, Tyler K., Lin, Albert P., Lin, Kevin, Lindemann, Janet C., Linder, Jeffrey A., Lock, James, Long, M. Chantel, Loo-Gross, Colleen, Malhotra, Uma, Manlove, Emily, Manson, JoAnn E., Mansukhani, Meghna P., Marcocci, Claudio, Margo, Curtis E., Marker, Jason E., Martin, Paul, Matson, Kristine, Matza, Mark A., Maxwell, Pinckney J., IV, May, Danica, Mazepa, Marshall, McGrew, Christopher, McGuigan, Christopher C., McGuigan, Michael, Meiselman, Mick S., Mercado, Moises, Merrell, Ryan, Meyers, Steven L., Miller, Brian J., Millington, Timothy M., Mirza, Moben, Mishra, Kriti, Mofenson, Howard C., Mogensen, Kris M., Morgenthaler, Timothy I., Moritz, Michael L., Mortada, Rami, Moser, Scott E., Moss, Heather E., Moul, Judd W., Mullen, Heidi E.K., Murinova, Natalia, Murphy, Michael, Mutasim, Diya F., Muthusubramanian, Arjun, Nagji, Alykhan S., Nazeef, Moniba, Neelakantan, Viswanathan K., Neff, Donald A., Neil, Tara J., Nelson, William G., Neschis, David G., Nester, Theresa, Nguyen, Tam T., Nicol, Andrea L., Nieves-Arriba, Lucybeth, Novac, Andrei, Novelli, Enrico M., Nye, Lauren, Obi, Andrea T., Okeson, Jeffrey P., Oliveira, Carlos R., Ong, Peck Y., Oram, Daniel S., Overturf, Gary D., Ozgonenel, Bulent, Pacak, Karel, Padin-Rosado, José A., Padungkiatsagul, Tanyatuth, Paladine, Heather L., Pandolfino, John E., Pasipanodya, Jotam, Passarella, Pasquale, Patel, Deval, Patton, Simon, Penna, Gerson Oliveira, Penna, Maria Lucia Fernandes, Perkins, Allen, Peterson, Leah, Petroianu, Georg A., Petronic-Rosic, Vesna M., Phan, Hanna, Pietroni, Mark, Pollart, Susan M., de Andrade Pontes, Maria Araci, Porter, Andrew S.T., Powell, Charles R., Pusateri, Margaret, Quinn, James M., Rahko, Peter S., Rajkumar, S. Vincent, Rakel, David P., Ramakrishnan, Kalyanakrishnan, Ramirez, Julio A., Rana, Jatin, Rank, Matthew A., Raoult, Didier, Rapose, Alwyn, Ravindran, Anita Devi K., Reddy, Elizabeth, Reid, Ian R., Rennert-May, Elissa, Rew, Karl T., Rezapour, Mona, Rhyne, Amanda, Riese, Martha, Robbins, David C., Robertson, Amy, Robinson, Malcolm K., Roche, William P., Rohrberg, Tessa E., Rose, Candice, Rose, Peter G., Rosenthal, Richard N., Ross, Stephen, Roth, Alan R., Ruha, Anne-Michelle, Rundell, Kristen, de Sá Gonçalves, Heitor, Said, Adnan, Sairenji, Tomoko, Samson, Susan L., Sanchez, Carlos E., Sangodkar, Sandeep, Santana, Arelis, Sarode, Ravi, Schatz, Michael, Schevchuck, Alex, Schiller, Lawrence R., Schoessow, Kim, Schrager, Sarina, Schuller, Dan, Seery, Amy, Seifert, Steven A., Semel, Jeffery D., Shaffi, Saeed Kamran, Shah, Beejal, Shah, Prediman K., Shah, Samir S., Shah, Shenil, Shammo, Jamile M., Shapiro, Eugene D., Sharara, Ala I., Sheehan, John P., Sherman, Kamille S., Shew, Sable, Sievers, Karlynn, Silk, Hugh, Simon, Lisa, Sinclair, Aaron D., Siraj, Dawd S., Sloane, Philip D., Smith, Zachary L., Sojka, John, Somers, William J., Song, Mihae, Sosa, Nestor, Sowder, Timothy, Speer, Linda, Spencer, Abby L., Stephens, Todd, St. Louis, Erik Kent, Stratakis, Constantine A., Stulberg, Daniel, Suárez, José Antonio, Takashima, Masayoshi, Takyar, Varun, Talhari, Carolina, Tang, Jie, Tate, Jessica, Templeton, Kim, Teng, Joyce M.C., Thomson, Joanna, Thrasher, J. Brantley, Tillett, William, Tobin, Kenneth, Tsaltas, Theodore T., Unizony, Sebastian H., Unruh, Mark, Uppendahl, Locke, Vallurupalli, Anusha, Van Buren, George, II, van Duin, David, Van Durme, Daniel J., Varlamov, Elena V., Vélez, Christopher, Vercellotti, Gregory, Vincent, Kyle, Vinh, Donald C., Vyas, Jatin M., Wagner, Tamara, Wakefield, Thomas W., Wald, Arnold, Wald, Ellen R., Walker, Robin A., Wall, Barry M., Wang, Andrew, Wang, Ernest, Wang, Jennifer, Watanabe, Koji, Weber, Ruth, Wehler, Cheryl, Wei, Alice C., Weida, Jane A., Weissman, David N., Welliver, Robert C., Sr., Wester, Rebecca M., Westergaard, Ryan P., Wexler, Randell, Whitley, Brian M., Wilamowska, Katarzyna, Williams, Kimberly, Williams, Tracy L., Winterhoff, Boris, Wipperman, Jennifer, Wittler, Robert, Wolf, Katherine I., Wood, Gary S., Worswick, Scott, Wu, Steve W., Wyre, Hadley, Yakubov, Steven J., Yang, Xinghong, Yew, Kenneth S., Yi, Yooni, Yiannias, James A., and Young, Natawadee
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- 2021
- Full Text
- View/download PDF
8. Contributors
- Author
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Abad, Kashif, Abdul-Hussein, Mustafa, Adam, Rodney D., Adams, Paul C., Ahmad, Faisal I., Akst, Lee, Anderson, Kelley P., Andre, Paul, Anstead, Gregory M., Aring, Ann M., Arshi, Arash, Avalos, Danny, Azar, Cecilio M., Azarbal, Amir, Baeseman, Zachary J., Bailey, Justin, Bajaj, Mandeep, Bakhutashvili, Vladimer, Balagué, Federico, Barth, Bradley E., Basello, Gina M., Bassaly, Renee M., Bassily-Marcus, Adel, Baughn, Julie M., Beard, Sheryl, Belakovskiy, Aleksandr, Ben-Ami, Ronen, Bencheqroun, Hassan, Bernstein, David I., Bernstein, Jonathan A., Biggerstaff, Kristin Schmid, Bloomfield, Clara, Blum, William, Bolotin, Diana, Bonnema, Rachel A., Borenstein, David, Bossart, Christopher, Bragg, Dee Ann, Bragg, Scott, Bremjit, Prasheda, Brewer, Takae, Brice, Sylvia L., Brill, John, Brown, Patricia D., Brown, Patrick, Brown, Rachel, Brown, Richard B., Buckley, Peter F., Burns, Sarah, Byrd, Kenneth, Cadavid, Diego, Caraccio, Thomas R., Carek, Peter J., Carrion, Andres F., Castell, Donald O., Cayley, William E., Jr., Cerquozzi, Sonia, Cervera, Alvaro, Chamberlain, Rachel, Chan, Lawrence, Chan, Miriam, Chen, Lin Yee, Chihara, Shingo, Chitlur, Meera, Chohan, Saima, Christensen, Jacob, Chyu, Kuang-Yuh, Cigarroa, Joaquin E., Clark, Peter E., Cleland, Paul, Cline, Matthew K., Clouse, Kari R., Coates, Laura C., Colenbrander, August, Collins, Tracie C., Commins, Ryan M., Conageski, Christine, Conly, John M., Contini, Carlo, Cooper, Ashley, Cormier, Allison K., Corriveau, Michael L., Cox, Bart L., Creech, Dustin A., Creo, Ana L., Cunha, Burke A., Cunha, Cheston B., Curry, Amy E., Dai, Julia, Daines, Cori L., Damas, Oriana M., Damitz, Beth A., Dattilo, Natalie C., Davaro, Raul, de Berker, David, de Leon, André, de Leon, Tate, DeCastro, Alexei, DeGeorge, Katharine C., DeLoughery, Thomas G., Deodhar, Atul, Dessinioti, Clio, Diamond, Michael P., Donnan, Geoffrey A., Dorsch, John N., Douglas, Chad, Drevets, Douglas A., Dudley, Samuel C., Jr., Duggan, Peter R., Eagle, Kim, Eck, Leigh M., Egnatios, Genevieve L., Elston, Dirk M., Embil, John M., Epstein, Scott K., Evans, Susan, Evens, Andrew M., Fagan, J. Barry, Faugno, Anthony J., III, Fayssoux, Kinder, Feldman, Dorianne, Fife, Terry D., Finley, David J., Fisher, William E., Fleseriu, Maria, Fletcher, Donald C., Flores, Raja, Forsberg, Sarah, Foster, Jeffrey Michael, Fox, Daniel P., Frank, Jennifer, Freelove, Robert S., Freeman, Ellen W., Freeman, Theodore M., Friedman, Aaron, Gaba, Ruchi, Gaines, Melissa, Gallagher, R. Michael, Ghany, Marc G., Ghazi, Muhammad Ahmad, Gibbs, Lawrence M., Gilbert, Donald L., Gillaspie, Erin A., Gilotra, Tarvinder, Gladwin, Mark T., Gluckman, Stephen J., Goddard, Andrew W., Goerl, Danae D., Goerl, Kyle, Gold, Mark S., Goldstein, Joshua N., Gonzales, Melissa K., González-Fernández, Marlis, Goodwin, Gregory, Gosmanov, Aidar R., Gosmanov, Niyaz, Gosmanova, Albina, Gradoni, Luigi, Graham, Timothy P., Grant-Kels, Jane M., Greenberg, Leslie A., Greene, William M., Greensher, Joseph, Gregory, David S., Greiwe, Justin, Gumbo, Tawanda, Hague, Melissa, Halder, Rebat M., Hall, Ronald, II, Harman, Lynn E., Harris, George D., Harris, Kari R., Harrison, Taylor B., Hartman, Adam L., Haynes, James W., Heidelbaugh, Joel J., Agudelo Higuita, Nelson Iván, Hinderliter, Stacey A., Hinshaw, Molly A., Ho, Vanessa, Hockenberry, Brandon, Hohl, Raymond J., Holguin, Therese, Holstein, Sarah A., Holubar, Marisa, Homan, Gretchen, Horn, Leora, Hossani-Madani, Ahmad Reza, House, Steven A., Houssayni, Sarah, Hueston, William J., Huffstetler, Alison N., Hundahl, Scott A., Hunger, Stephen P., Hupp, Wendy S., Irwin, Gretchen M., Isenberg, Gerald A., Jackson, Alan C., Jacobson, Kurt M., Jain, Vasudha, Jaller, Jose A., James, James J., Jamieson, Katarzyna, Jia, Xiaoming, Johnson, Lisa M., Jolissaint, Joshua S., Juckett, R. Gregory, Judson, Marc A., Kadhiravan, Tamilarasu, Kalia, Rachna, Kanter, Jessica, Karnad, Dilip R., Katsambas, Andreas, Katz, Ben Z., Katzman, Rebecca, Kaufer, Daniel I., Kaunitz, Andrew M., Keegan, B. Mark, Kellerman, Rick D., Kellermann, Scott, Kelly, Christina M., Kim, Arthur Y., Kim, Haejin, Kim, Jongoh, Kirsner, Robert S., Kiwalkar, Sonam, Kolb, Amanda, Kolla, Bhanu Prakash, Korley, Frederick K., Kovalsky, Adrienne N., Krause, Megan, Kraut, Eric H., Krishnamurti, Lakshmanan, Krishnan, Kumar, Kuhlmann, Zachary, Kulkarni, Roshni, Kumar, Seema, Kwaan, Mary R., Kyle, Robert A., Lampton, Lucius M., Lange, Richard A., Langlois, Fabienne, Larioza, Julius, Larkin, Jerome, Lau, Christine L., Lawrence-Hylland, Susan, Lee, Lydia U., Leikin, Jerrold B., Leikin, Scott, Leung, Alexander K.C., LeWinter, Martin M., Lewis, Jennifer, Li, Ming, Liebenstein, Tyler K., Lin, Albert P., Lindemann, Janet C., Linder, Jeffrey A., Lock, James, Long, M. Chantel, Loo-Gross, Colleen, Lyznicki, James M., Malaeb, Bahaa S., Malhotra, Uma, Malone, Michael A., Manlove, Emily, Manson, JoAnn E., Mansukhani, Meghna P., Marcocci, Claudio, Margo, Curtis E., Marker, Jason E., Martin, Paul, Matza, Mark A., Maxwell, Pinckney J., IV, McCall, Anthony L., McGrew, Christopher, McGuigan, Christopher C., McGuigan, Michael, Meiselman, Mick S., Mercado, Moises, Merrell, Ryan, Meyers, Steven L., Miller, Brian J., Mirza, Moben, Mishra, Kriti, Mofenson, Howard C., Mogensen, Kris M., Morgenthaler, Timothy I., Morison, Warwick L., Mortada, Rami, Moser, Scott E., Moss, Heather E., Mostaghimi, Ladan, Moul, Judd W., Mullen, Heidi E.K., Murphy, Michael, Mutasim, Diya F., Muthusubramanian, Arjun, Nagji, Alykhan S., Nazeef, Moniba, Neff, Donald A., Neil, Tara J., Nelson, William G., Neschis, David G., Nester, Theresa, Nguyen, Tam T., Nicol, Andrea L., Nieves-Arriba, Lucybeth, Novac, Andrei, Novelli, Enrico M., Nye, Lauren, Obi, Andrea T., Okeson, Jeffrey P., Oliveira, Carlos R., Ong, Peck Y., Oram, Daniel S., Overturf, Gary D., Ozgonenel, Bulent, Pacak, Karel, Padin-Rosado, Jose A., Pandolfino, John E., Paran, Yael, Pasipanodya, Jotam, Passarella, Pasquale, Patton, Simon, Penna, Gerson O., Penna, Maria Lucia, Perkins, Allen, Peterson, Leah, Petroianu, Georg A., Petronic-Rosic, Vesna M., Phan, Hanna, Pierach, Claus A., Pietroni, Mark, Pollart, Susan M., de Andrade Pontes, Maria, Porter, Andrew S.T., Powell, C.R., Pusateri, Margaret, Rahko, Peter S., Rajkumar, S. Vincent, Ramakrishnan, Kalyanakrishnan, Ramirez, Julio A., Rank, Matthew A., Raoult, Didier, Ravindran, Anita Devi K., Reddy, Elizabeth, Regis, Deon, Reid, Ian R., Rennert-May, Elissa, Rew, Karl T., Rezapour, Mona, Rhyne, Amanda, Robertson, Amy, Robinson, Malcolm K., Roche, William P., Roett, Michelle, Rose, Peter G., Rosenthal, Richard N., Roth, Alan R., Ruha, Anne-Michelle, Rundell, Kristen, Sadovsky, Richard, de Sá Gonçalves, Heitor, Said, Adnan, Sairenji, Tomoko, Samson, Susan L., Sanchez, Carlos E., Sangodkar, Sandeep, Sarode, Ravi, Saunders, J. Terry, Schatz, Michael, Schevchuck, Alex, Schiller, Lawrence R., Schoessow, Kim, Schrager, Sarina, Schuller, Dan, Scripter, Cassie, Seery, Amy, Seifert, Steven A., Semel, Jeffery D., Shaffi, Saeed Kamran, Shah, Beejal, Shah, Prediman K., Shah, Samir S., Shah, Shenil, Shammo, Jamile M., Shapiro, Eugene D., Sharara, Ala I., Sheehan, John P., Shew, Sable, Shulman, Abraham, Sievers, Karlynn, Silk, Hugh, Sinclair, Aaron, Sloane, Philip D., Smith, Zachary L., Somers, William J., Sowder, Timothy, Speer, Linda, Spencer, Abby L., Kent, Erik, Stephens, Todd, Stevens, Dennis L., Stone, John H., Stratakis, Constantine A., Stulberg, Daniel, Takashima, Masayoshi, Takyar, Varun, Talhari, Carolina, Tang, Jie, Tate, Jessica, Teng, Joyce M.C., Thomson, Joanna, Thrasher, J. Brantley, Tillett, William, Tobin, Kenneth, Tsaltas, Theodore T., Underman, Arvid E., Unruh, Mark, Uppendahl, Locke, Vallurupalli, Anusha, Van Buren, George, II, van Duin, David, Van Durme, Daniel J., Vincent, Kyle, Vinh, Donald C., Viswanathan, K.N., Vyas, Jatin M., Wakefield, Thomas W., Wald, Arnold, Wald, Ellen R., Walker, Robin A., Wall, Barry M., Walling, Anne, Wang, Andrew, Wang, Ernest, Wang, Jennifer, Watanabe, Koji, Weber, Ruth, Wehler, Cheryl, Weida, Jane A., Weissman, David N., Welliver, Robert C., Sr., Wester, Rebecca M., Westergaard, Ryan P., Wexler, Randell, Whitley, Brian M., Wilamowska, Katarzyna, Williams, Kimberly, Williams, Tracy L., Winterhoff, Boris, Wipperman, Jennifer, Wittler, Robert, Wood, Gary S., Worswick, Scott, Wu, Steve W., Wyre, Hadley, Yakubov, Steven J., Yang, Xinghong, Yi, Yooni, Yiannias, James A., Young, Nata, Zafereo, Mark E., and Zuckerman, Jane
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- 2020
- Full Text
- View/download PDF
9. Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice
- Author
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Vivekananda Gupta, Sunkari, Folke, Lind, Ileana Ruxandra, Botusan, Abad, Kashif, Zhao-Jun, Liu, Seppo, Ylä-Herttuala, Kerstin, Brismar, Omaida, Velazquez, and Sergiu-Bogdan, Catrina
- Subjects
Male ,Mice, Inbred C57BL ,Hyperbaric Oxygenation ,Mice ,Wound Healing ,Animals ,Neovascularization, Physiologic ,Hypoxia ,Hypoxia-Inducible Factor 1, alpha Subunit ,Diabetic Foot ,Cell Proliferation ,Diabetes Mellitus, Experimental - Abstract
Hyperbaric oxygen (HBO) therapy has been used as an adjunctive therapy for diabetic foot ulcers, although its mechanism of action is not completely understood. Recently, it has been shown that HBO mobilizes the endothelial progenitor cells (EPCs) from bone marrow that eventually will aggregate in the wound. However, the gathering of the EPCs in diabetic wounds is impaired because of the decreased levels of local stromal-derived factor-1α (SDF-1α). Therefore, we investigated the influence of HBO on hypoxia-inducible factor 1 (HIF-1), which is a central regulator of SDF-1α and is down-regulated in diabetic wounds. The effects of HBO on HIF-1α function were studied in human dermal fibroblasts, SKRC7 cells, and HIF-1α knock-out and wild-type mouse embryonic fibroblasts using appropriate techniques (Western blot, quantitative polymerase chain reaction, and luciferase hypoxia-responsive element reporter assay). Cellular proliferation was assessed using H(3) -thymidine incorporation assay. The effect of HIF in combination with HBOT was tested by inoculating stable HIF-1α-expressing adenovirus (Adv-HIF) into experimental wounds in db/db mice exposed to HBO. HBO activates HIF-1α at several levels by increasing both HIF-1α stability (by a non-canonical mechanism) and activity (as shown both by induction of relevant target genes and by a specific reporter assay). HIF-1α induction has important biological relevance because the induction of fibroblast proliferation in HBO disappears when HIF-1α is knocked down. Moreover, the local transfer of stable HIF-1α-expressing adenovirus (Adv-HIF) into experimental wounds in diabetic (db/db mice) animals has an additive effect on HBO-mediated improvements in wound healing. In conclusion, HBO stabilizes and activates HIF-1, which contributes to increased cellular proliferation. In diabetic animals, the local transfer of active HIF further improves the effects of HBO on wound healing.
- Published
- 2013
10. The Management of Hypertension in Elderly Patients with Chronic Kidney Disease.
- Author
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Abad, Kashif, Rivera, Francisco X., and Owen, Jonathan G.
- Published
- 2018
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