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1. OP0033 FIBROBLAST GENE, FKBP7 INDUCED BY Ca2+DEPENDENT ER STRESS ASSOCIATED WITH CLINICAL OUTCOME IN RHEUMATOID ARTHRITIS AND CROHN’S DISEASE; MULTI-CENTRE GWAS AND FUNCTIONAL STUDIES

Author

Maurits, M. P., primary, Cameron, A., additional, Jelinsky, S., additional, Blüml, S., additional, Abasolo, L., additional, Askling, J., additional, Barton, A., additional, Böhringer, S., additional, Cope, A., additional, De, S., additional, Emery, P., additional, Eyre, S., additional, Gaddi, V. P., additional, González-Álvaro, I., additional, Goodyear, C. S., additional, Hu, X., additional, Huizinga, T., additional, Johannesson, M., additional, Jurado-Zapata, S., additional, Klareskog, L., additional, Lendrem, D., additional, Martin, P., additional, Mc Innes, I. B., additional, Micheroli, R., additional, Morgan, A., additional, Morton, F., additional, Naamane, N., additional, Nagafuchi, Y., additional, Orozco, G., additional, Padyukov, L., additional, Paterson, C., additional, Pitzalis, C., additional, Plant, D., additional, Porter, D., additional, Reynard, L., additional, Rodriguez Rodriguez, L., additional, Sieghart, D., additional, Studenic, P., additional, Taylor, J., additional, Toes, R. E. M., additional, Van den Akker, E. B., additional, Van der Helm – van Mil, A. H. M., additional, Vaskimo, L., additional, Verstappen, S., additional, Westerlind, H., additional, Isaacs, J., additional, Lewis, M., additional, Pratt, A., additional, Ospelt, C., additional, Winkler, A., additional, Thomas, R., additional, and Knevel, R., additional

Published
2024
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2. POS0925 VISUAL MANIFESTATIONS IN GIANT CELL ARTERITIS: IDENTIFICATION OF RISK FACTORS FROM THE ARTESER REGISTRY

Author

Molina-Collada, J., primary, Dominguez-Alvaro, M., additional, Melero-González, R. B., additional, Fernández-Fernández, E., additional, Silva-Díaz, M., additional, Valero Jaimes, J. A., additional, González, I., additional, Sanchez-Martín, J., additional, Narváez, J., additional, Calvo, I., additional, Mendizabal, J., additional, Abasolo, L., additional, Loricera, J., additional, Ruiz Román, A., additional, Moya, P., additional, Tortosa Cabañas, M., additional, Estrada, P., additional, Prado, F. J., additional, Castañeda, S., additional, and Blanco, R., additional

Published
2024
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3. AB1451 NEW APPROACHES TO THE STUDY OF SOCIAL DETERMINANTS OF HEALTH: DISCOVERY, EXTRACTION AND CHARACTERISATION OF MUSCULOSKELETAL PATIENTS’ OCCUPATIONS IN THE ELECTRONICAL MEDICAL RECORD USING DEEP LEARNING AND PRE-TRAINED LANGUAGE MODELS

Author

Madrid García, A., primary, Pérez - Sancristóbal, I., additional, León, L., additional, Abasolo, L., additional, Rodríguez González, A., additional, Fernández-Gutiérrez, B., additional, Menasalvas Ruiz, E., additional, and Rodriguez Rodriguez, L., additional

Published
2024
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4. Déchiffrer la pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde en utilisant une analyse en cluster hiérarchique non supervisée : résultats d’une collaboration internationale

Author

Juge, P.A., primary, Granger, B., additional, El Houari, L., additional, Mcdermott, G., additional, Doyle, T., additional, Kelly, C., additional, Gouri, K., additional, Vassallo, R., additional, Alarcon Calderon, A., additional, Kalyoncu, U., additional, Gonzales, A., additional, Mena-Vazquez, N., additional, Rojas-Gimenez, M., additional, Dos Santos-Sobrin, R., additional, Retuerto-Guerrero, M., additional, Vadillo-Font, C., additional, Vela, P., additional, Fernandez-Nebro, A., additional, Escudero-Contreras, A., additional, Pérez-Pampin, E., additional, Pablos-Alvarez, J.L., additional, Abasolo, L., additional, Hyldgaard, C., additional, Froidure, A., additional, Durez, P., additional, Rojas-Serrano, J., additional, Van Moorsel, C., additional, Grutters, J., additional, Kawano, L., additional, Lucas, C., additional, Jouneau, S., additional, Sanmartí, R., additional, Castellanos Moreira, R., additional, Antoniou, K., additional, Molina Molina, M., additional, Solomon, J., additional, Raia, S., additional, González-Gay, M.A., additional, Atienza-Mateo, B., additional, Flouda, S., additional, Effrosyni, M., additional, Boumpas, D., additional, Papiris, S., additional, Karageorgas, T., additional, Sebastiani, M., additional, Manfredi, A., additional, Duarte, A.C., additional, Crestani, B., additional, Sparks, J., additional, and Dieudé, P., additional

Published
2023
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10. POS1030 DNA-METHYLATION PROFILING IN THE BLOOD OF PATIENTS WITH RHEUMATOID ARTHRITIS-ASSOCIATED INTERSTITIAL LUNG DISEASE

Author

Kaczmarczyk, B., primary, De la Calle-Fabregat, C., additional, Duarte, A. C., additional, Mena-Vázquez, N., additional, Fernandez-Nebro, A., additional, Triguero-Martinez, A., additional, Castañeda, S., additional, Dos-Santos, R., additional, Mera Varela, A., additional, Lopez-Pedrera, C., additional, Escudero Contreras, A., additional, Vela-Casasempere, P., additional, Molina Molina, M., additional, Narváez, J., additional, Retuerto-Guerrero, M., additional, Pablos, J. L., additional, Sarmiento-Monroy, J. C., additional, Sanmartí, R., additional, Gómez Carrera, L., additional, Bonilla, G., additional, Remuzgo Martinez, S., additional, González-Gay, M. A., additional, Leiro Fernandez, V., additional, Pérez Gómez, N., additional, Vadillo, C., additional, Abasolo, L., additional, Casafont-Solé, I., additional, Mateo Soria, L., additional, Castillo González, A. C., additional, Marras Fernandez Cid, C., additional, Perez-Pampín, E., additional, Ballestar, E., additional, and Gonzalez, A., additional

Published
2023
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11. AB0148 IDENTIFICATION OF CANDIDATE miRNA MOLECULES AS BIOMARKERS IN INTERSTITIAL PNEUMONIA WITH AN UNDERLYING AUTOIMMUNE DISEASE. A DISCOVERY COHORT FROM THE NEREA PROJECT

Author

Rodriguez, M. J., primary, Vegas Sánchez, M. C., additional, López-Muñiz, B., additional, Romero Bueno, F., additional, Vadillo, C., additional, Nieto, M. A., additional, Cebrián Méndez, L., additional, Godoy, H., additional, Laporta, R., additional, Abasolo, L., additional, Bonilla, G., additional, Gómez Carrera, L., additional, and Sanchez Pernaute, O., additional

Published
2023
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14. POS1427 CLINICAL COURSE IN PATIENTS WITH INTERSTITIAL PNEUMONIA WITH AUTOIMMUNE FEATURES (IPAF): REAL-LIFE DATA FROM A MULTICENTER ILD REGISTRY

Author

Vadillo, C., primary, Nieto, M. A., additional, Sanchez Pernaute, O., additional, Romero, F., additional, Rodriguez, M. J., additional, Freites Nuñez, D., additional, Bonilla, G., additional, Cobo, T. I., additional, Cebrián Méndez, L., additional, Godoy, H., additional, Rio, M. T., additional, and Abasolo, L., additional

Published
2022
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15. AB1171 PERSISTENT POST-DISCHARGE SYMPTOMS AFTER COVID-19 IN RHEUMATIC AND MUSCULOSKELETAL DISEASES

Author

Perez-Sancristobal, I., primary, León, L., additional, Álvarez Hernandez, M. P., additional, Madrid García, A., additional, Lopez Pedraza, L., additional, Colomer, J. I., additional, Lerma Lara, S., additional, Lois, P., additional, Mucientes, A., additional, Rodriguez Rodriguez, L., additional, Fernandez, B., additional, and Abasolo, L., additional

Published
2022
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16. POS0795 EPIDEMIOLOGY, DIAGNOSIS AND CLINICAL CHARACTERISTICS OF GIANT CELL ARTERITIS IN PATIENTS INCLUDED IN THE ARTESER MULTICENTER STUDY

Author

Sánchez-Costa, J. T., primary, Melero González, R. B., additional, Fernández-Fernández, E., additional, Silva, M. T., additional, Belzunegui Otano, J. M., additional, Moriano, C., additional, Sanchez-Martin, J., additional, Lluch Pons, J., additional, Calvo, I., additional, Aldasoro, V., additional, Abasolo, L., additional, Loricera, J., additional, Ruiz Román, A., additional, Castañeda, S., additional, Moya, P., additional, Garcia Villanueva, M. J., additional, Navarro Angeles, V. A., additional, Galisteo, C., additional, Riveros, A., additional, Román Ivorra, J. A., additional, Labrada, S., additional, Vasques Rocha, M., additional, Iñíguez, C. L., additional, Garcia Gonzalez, M., additional, Molina, C., additional, Alcalde Villar, M., additional, Mas, A. J., additional, De Miguel, E., additional, Narváez, J., additional, González-Gay, M. A., additional, Garrido Puñal, N. P., additional, Estrada, P., additional, and Blanco, R., additional

Published
2022
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21. POS1253 MORTALITY RATE RELATED TO COVID - 19 IN RHEUMATIC AND MUSCULOSKELETAL DISEASES (RMDs)

Author

Freites, D., primary, Perez-Sancristobal, I., additional, Lopez Pedraza, L., additional, Álvarez Hernandez, M. P., additional, Hernandez, I., additional, Colomer, J. I., additional, Madrid García, A., additional, Fernandez, B., additional, Vadillo, C., additional, Rodriguez Rodriguez, L., additional, Mucientes, A., additional, León, L., additional, and Abasolo, L., additional

Published
2021
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24. AB0290 HERPES ZOSTER INFECTIONS IN RHEUMATOID ARTHRITIS PATIENTS EXPOSED TO BIOLOGICAL AGENTS AND JAK INHIBITORS. REAL-WORLD EVIDENCE.

Author

Freites Nuñez, D., primary, Abasolo, L., additional, Peñuelas, M., additional, Candel, F. J., additional, Font, J., additional, Lois, P., additional, Martinez Prada, C., additional, Fernandez, B., additional, Madrid García, A., additional, Rodriguez Rodriguez, L., additional, Colomer, J. I., additional, and León, L., additional

Published
2020
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29. Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA Project

Author

Martin-Martinez M, Castaneda S, Gonzalez-Juanatey C, Sanchez-Alonso F, Garcia-Gomez C, Lopez-Gonzalez R, Babio-Herraiz J, Juan-Mas A, Moreno-Gil M, Sanchez-Gonzalez C, Romera-Baures M, Pinto-Tasende J, Tornero-Molina J, Fabregas-Canales D, Llorca J, Gonzalez-Gay M, de Rabago E, Morales E, Lopez J, Villar N, Sandoval A, Garcia F, De Miquel C, Fernandez M, Codina R, Yoldi B, Ramentol M, Avila G, Barril S, Quesada E, Steiner M, Munoz S, Cobo T, Gamero F, Toron J, Espino P, Ros I, Ibanez M, Murillo C, Sanmarti R, Berman H, Cabrera S, Ruiz V, Paton O, Gutierrez B, Abasolo L, Pina J, Nolla J, Arias M, Vadillo J, de Vicuna R, Nebro A, Arija S, Lopez M, Urena I, Irigoyen M, Cagigal V, Garrido D, Aparicio A, Gomez R, Bautista P, Sanz A, Bachiller J, Manero F, Zorzo F, Ubeda E, Garcia J, Audera C, Medrano M, Pecondon A, Erausquin C, Ojeda S, Quevedo J, Francisco F, Lozano C, Longo F, Gerona D, Fernandez C, Monteagudo I, del Pino J, Gonzalez M, Corrales A, Peiro M, Senabre J, Rosas J, Rotes I, Moreno E, Erra A, Grado D, Calvo J, Rueda A, Moller I, Rodriguez I, Barbadillo C, Raya E, Morales P, Nieto A, Jimenez I, Magro C, Escribano A, Exposito S, Nievas G, Navarro E, Morales M, Bastero I, Consuegra G, Palmou N, Pardo S, Pujol M, Alonso E, Salvador G, Alvarez B, Cantabrana A, Bustabad S, Delgado E, Munoz A, Montero S, Jimenez L, Redondo J, Hernandez T, Polo F, Almagro R, Moreno J, Serret E, Barroso C, Mendez L, Navio M, Carballido C, Pagan E, del Castillo P, Naredo E, Cruz A, Turrion A, Sanchez J, Galindo M, Gonzalez J, Collantes E, Ruiz D, Font P, Bonilla G, Meseguer A, Moreno M, Martinez M, Linares L, Morcillo M, Gomez M, Rivera N, Berrizbeitia O, Vivar M, Riera M, Leon Y, Maymo J, Amirall M, Escolano S, Serrano S, Bona M, Fiter J, Melon J, Espadaler L, Maiz O, Belzunegui J, Banegil I, Diaz C, Valls R, Castellvi I, Bonet M, Ruzafa E, Alen J, Sandoval T, Evrard E, Godo J, Espartero C, Blasco F, Miranda-Filloy J, and CARMA Project Collaborative Grp

Subjects
rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, incidence, cohort study, CARMA project, cardiovascular diseases
Abstract

Objective To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD). Methods Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. CVE cumulative incidence per 1000 patients was calculated after 2.5 years from the start of the project. Weibull proportional hazard model was used to calculate hazard ratio (HR) and 95% confidence interval (95% CI) of the risk factors. Results 2595 (89.1%) patients completed the 2.5 years of follow-up visit. Cumulative incidence of CVE in patients with CIRD was 15.30 cases per 1000 patients (95% CI: 12.93-17.67), being higher in the subgroup with AS; 22.03 (95% CI: 11.01-33.04). Patients with AS (HR: 4.11; 95% CI: 1.07-15.79), those with older age (HR: 1.09; 95% CI: 1.05-1.13), systolic hypertension (HR: 1.02; 95% CI: 1.00-1.04) and long duration of the disease (HR: 1.07; 95% CI: 1.03-1.12) were at higher risk of first CVE during the 2.5 years of follow-up. In contrast, female gender was a protective factor (HR: 0.43; 95% CI: 0.18-1.00). Conclusion Among CIRD patients prospectively followed-up at rheumatology outpatient clinics, those with AS show higher risk of first CVE. Besides cardiovascular risk factors, such as hypertension, being a man and older

Published
2019

30. Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project

Author

Garcia-Gomez, C, Martin-Martinez, M, Fernandez C, Castaneda, S, Gonzalez-Juanatey, C, Sanchez-Alonso, F, Gonzalez-Fernandez, M, Sanmarti, R, Garcia-Vadillo, J, Fernandez-Gutierrez, B, Garcia-Arias, M, Manero, F, Senabre, J, Rueda-Cid, A, Ros-Exposito, S, Pina-Salvador, J, Erra-Duran, A, Moller-Parera, I, Llorca, J, Gonzalez-Gay, M, Gonzalez de Rabago, E, Blanco Morales, E, Fernandez Lopez, J, Oreiro Villar, N, Atanes Sandoval, A, Blanco Garcia, F, Alegre De Miquel, C, Gonzalez Fernandez, M, Huguet Codina, R, Yoldi, B, Ramentol, M, Avila, G, Marsal Barril, S, Steiner, M, Munoz, S, Gamero, F, Garcia Toron, J, Moreno Gil, M, Mas, A, Espino, P, Ros, I, Ibanez, M, Murillo, C, Piqueras, J, Berman, H, Cabrera, S, Ruiz, V, Fontsere Paton, O, Fernandez Gutierrez, B, Abasolo, L, Fabregas, M, Romera Baures, M, Nolla, J, Gonzalez-Alvaro, I, Tomero Muriel, E, Garcia de Vicuna, R, Fernandez Nebro, A, Belmonte Lopez, M, Urena, I, Irigoyen, M, Coret Cagigal, V, Lopez Gonzalez, R, Pielfort Garrido, D, Sampedro Alvarez, J, Garcia Aparicio, A, Belmonte Gomez, R, Granados Bautista, P, Hernandez Sanz, A, Sanchez Gonzalez, C, Bachiller, J, Zea, A, Jimenez Zorzo, F, Gimenez Ubeda, E, Marzo Gracia, J, Beltran Audera, C, Medrano, M, Pecondon, A, Erausquin, C, Ojeda, S, Carlos Quevedo, J, Francisco, F, Rodriguez Lozano, C, Babio Herraez, J, Lopez Longo, F, Gerona, D, Gonzalez Fernandez, C, Carreno, L, Monteagudo, I, del Pino, J, Sanchez Gonzalez, M, Corrales, A, Enriqueta Peiro, M, Rosas, J, Rotes, I, Moreno, E, Erra, A, Grado, D, Calvo, J, Rueda, A, Moller, I, Rodriguez, I, Barbadillo, C, Raya, E, Morales, P, Nieto, A, Jimenez, I, Magro, C, Ruibal Escribano, A, Ros Exposito, S, Sanchez Nievas, G, Judez Navarro, E, Sianes Fernandez, M, Garcia Morales, M, Labiano Bastero, I, Consuegra, G, Palmou, N, Martinez Pardo, S, Pujol, M, Riera Alonso, E, Salvador, G, Gonzalez Alvarez, B, Cantabrana, A, Bustabad, S, Delgado, E, Munoz, A, Rodriguez Montero, S, Maria Jimenez, L, Rivera Redondo, J, Gonzalez Hernandez, T, Gonzalez Polo, F, Menor Almagro, R, Moreno, J, Giner Serret, E, Lannuzzelli Barroso, C, Cebrian Mendez, L, Teresa Navio, M, Fernandez Carballido, C, Pagan, E, Mesa del Castillo, P, Naredo, E, Cruz, A, Turrion, A, Mateo, I, Sanchez, J, Galindo, M, Garcia Gonzalez, J, Collantes, E, Ruiz, D, Font, P, Bonilla, G, Lopez Meseguer, A, Moreno, M, Moreno Martinez, M, Beteta Fernandez, M, Linares, L, Morcillo, M, Gonzalez Gomez, M, Aramburu, J, Rivera, N, Fernandez Berrizbeitia, O, Garcia Vivar, M, Riera, M, Maria Leon, Y, Maymo, J, Amirall, M, Iniesta Escolano, S, Sanchez Serrano, S, Lis Bona, M, Fiter, J, Fernandez Melon, J, Espadaler, L, Maiz, O, Belzunegui, J, Banegil, I, Diaz, C, Valls, R, Castellvi, I, Bonet, M, Moreno Ruzafa, E, Calvo Alen, J, Perez Sandoval, T, Revuelta Evrard, E, Godo, J, Fernandez Espartero, C, Navarro Blasco, F, Antonio Gonzalez, J, Miranda-Filloy, J, and CARMA Project Collaborative Grp

Subjects
musculoskeletal diseases, psoriatic arthritis, lipids, stomatognathic diseases, cardiovascular disease, lipoprotein(a), ankylosing spondylitis, spondyloarthritis
Abstract

Objective Cardiovascular (CV) disease is one of the main causes of morbi-mortality in spondyloarthritis (SpA), partially explained by traditional CV risk factors. Information on lipoprotein(a) [Lp(a)], a non-conventional risk factor, in SpA is scarce. In this study we assessed the prevalence of hyperlipoproteinaemia(a) in SpA patients and analysed the possible related factors. Methods A baseline analysis was made of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients and controls included in the CARMA project (CARdiovascular in RheuMAtology), a 10-year prospective study evaluating the risk of CV events in chronic inflammatory rheumatic diseases. A multivariate logistic regression model was performed using hyperlipoproteinaemia( a) (Lp(a) >50 mg/dl) as a dependent variable and adjusting for confounding factors. Results 19.2% (95% CI: 16.80-22.05) of the SpA patients [20.7% (95% CI: 16.91-24.82) of those with AS and 17.7% (95% CI: 14.15-21.75) of those with PsA] and 16.7% (95% CI: 13.23-20.86) of the controls had hyperlipoproteinaemia(a) (p=0.326). Adjusting for age and sex, SpA patients were more likely to have hyperlipoproteinaemia(a) than controls (OR: 1.43, 95% CI: 1.00-2.04; p=0.05), especially those with AS (OR: 1.81, 95% CI: 1.18-2.77; p=0.007). In the adjusted model, apolipoprotein B in all patients, non-steroidal anti-inflammatory drugs in AS, and female sex in PsA, were associated with hyperlipoproteinaemia(a). No disease-specific factors associated with hyperlipoproteinaemia(a) were identified. Conclusion SpA patients show a moderately increased risk of hyperlipoproteinaemia(a) compared to controls, especially those with AS. Lp(a) determination may be of interest to improve the CV risk assessment in SpA patients.

Published
2019

39. Influence of demographic and clinical factors on the mortality rate of a rheumatoid arthritis cohort: A 20-year survival study

Author

Abasolo, L, Ivorra-Cortes, J, Leon, L, Jover, JA, Fernandez-Gutierrez, B, and Rodriguez-Rodriguez, L

Subjects
Radiographic joint damage, Rheumatoid arthritis, Mortality, Survival analysis
Abstract

Objectives: To describe the mortality rate (MR) and standardized MR (SMR) of an incident cohort of rheumatoid arthritis (RA) patients followed up for 20 years, and to analyze the influence on morality risk of different demographic and clinical variables, including radiographic joint damage. Methods: Retrospective longitudinal study that included 2271 RA patients attending the rheumatology outpatient clinic of the Hospital Clinico San Carlos (Madrid, Spain), enrolled from January 1994 to February 2013 and followed up from RA diagnosis to patients' death or September 2013. Disability and disease activity were measured as the averaged value of the Heath Assessment Questionnaire and the erythrocyte sedimentation rate, respectively, of the first 2 years after RA diagnosis. Radiographic joint damage of hands and wrists was assessed with the Sharp/van der Heijde score. Indirect SMRs with a 95% of confidence interval (95% CI) were calculated. Cox bivariate and multivariate regression models were performed to assess risk factors for death. Results: A total of 431 patients died (19%) during the observation time (18,482 person-years), resulting in a MR of 23 subjects per 1000 patient-years [95% CI: 21-261. SMR was 1.89 (1.72-2.08). In the multivariate analysis, men, older age at diagnosis, the presence of rheumatoid factor, higher number of hospital admissions, greater disease activity, and greater radiographic joint damage were independently associated with greater mortality risk. Conclusions: RA patients have an excess mortality compared with the general population. Radiological joint damage and early disease activity are independent mortality risk factors. A tighter control at early stages may be necessary to reduce mortality. (C) 2016 Elsevier Inc. All rights reserved.

Published
2016

46. AB1152 Early Intervention in Musculoskeletal Disease Can Reduce Temporary Work Disability

Author

Vela, P., primary, Abasolo, L., additional, Lajas, C., additional, Gil, S., additional, Cuenca, N., additional, Senabre, J.M., additional, Lopez, A., additional, Barros, A., additional, Macia, C., additional, Tejon, P., additional, Aparicio, M., additional, Rosas, J., additional, Perez, T., additional, Valdazo, J.P., additional, Medina, J., additional, Belmonte, M.A., additional, Nolla, J.M., additional, and Jover, J.A., additional

Published
2015
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