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1. Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial

Author

Jaber, Samir, Pensier, Joris, Futier, Emmanuel, Paugam-Burtz, Catherine, Seguin, Philippe, Ferrandiere, Martine, Lasocki, Sigismond, Pottecher, Julien, Abback, Paër-Sélim, Riu, Beatrice, Belafia, Fouad, Constantin, Jean-Michel, Verzilli, Daniel, Chanques, Gérald, De Jong, Audrey, and Molinari, Nicolas

Published
2024
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2. Evaluating the Sum of Eye and Motor Components of the Glasgow Coma Score As a Predictor of Extubation Failure in Patients With Acute Brain Injury

Author

Taran, Shaurya, Perrot, Bastien, Angriman, Federico, Cinotti, Raphael, Abback, Paër-sélim, Codorniu, Anaïs, Citerio, Giuseppe, Ludovica Sala, Vittoria, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Giuseppina Maugeri, Jessica, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, Battaglini, Denise, Biston, Patrick, Fathi Al-Gharyani, Mohamed, Chabanne, Russell, ASTIER, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Marcel Gerretsen, Benjamin, Xochitl Ortiz-Macias, Iris, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J, Daniel Cornet, Alexander, Reyes Inurrigarro, Sergio, Cirino Lara Domínguez, Rafael, Mercedes Bellini, Maria, Milagros Gomez Haedo, Maria, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronia, Arvind, Carlos Miranda-Ackerman, Roberto, José Barbosa-Camacho, Francisco, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Compagnon, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Basheer Yahya, Hana, Khaled, Ala, Ghula, Mohamed, Neville Andrea, Cracchiolo, Maria Daniela, Palma, Deana, Cristian, Vetrugno, Luigi, Rivera Chavez, Manuel J., Mendoza Trujillo, Rocio, LEGROS, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Edward Coombs, Alexander, Welbourne, Jessie, Velarde Pineda, Ana Alicia, Nubert Castillo, VÍctor Hugo, Azab, Mohammed A, Azzam, Ahmed Y, Paul van Meenen, David Michael, Adrian Gasca, Gilberto, Arellano, Alfredo, Galicia-Espinosa, Forttino, Carlos García-Ramos, José, Yadav, Ghanshyam, Kumar Jha, Amarendra, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Adrian Gasca, Gilberto, Arellano, Alfredo, Tariq Reza, Syed, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, van Steenkiste, Job, van der Jagt, Mathieu, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Bedanta Mishra, Shakti, Samal, Samir, Cesar Mijangos, Julio, Haënggi, Mattias, Gurjar, Mohan, Schultz, Marcus J, Kaye, Callum, Agustin Godoy, Daniela, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Badenes, Rafael, Suei Elbuzidi, Abdurrahmaan Ali, Piagnerelli, Michaël, Elhadi, Muhammed, Tariq Reza, Syed, Atef Azab, Mohammed, Catherine Digitale, Jean, Fong, Nicholas, Campos Cerda, Ricardo, de la Torre Peredo, Norma, Pirracchio, Romain, and David Stevens, Robert

Published
2024
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3. Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial

Author

DE JONG, AUDREY, BIGNON, ANNE, STEPHAN, FRANÇOIS, GODET, THOMAS, CONSTANTIN, JEAN-MICHEL, ASEHNOUNE, KARIM, SYLVESTRE, AUDE, SAUTILLET, JULIETTE, BLONDONNET, RAIKO, FERRANDIERE, MARTINE, SEGUIN, PHILIPPE, LASOCKI, SIGISMOND, ROLLE, AMELIE, FAYOLLE, PIERRE-MARIE, MULLER, LAURENT, PARDO, EMMANUEL, TERZI, NICOLAS, RAMIN, SEVERIN, JUNG, BORIS, ABBACK, PAER-SELIM, GUERCI, PHILIPPE, SARTON, BENJAMINE, ROZE, HADRIEN, DUPUIS, CLAIRE, COUSSON, JOEL, FAUCHER, MARION, LEMIALE, VIRGINIE, CHOLLEY, BERNARD, CHANQUES, GERALD, BELAFIA, FOUAD, HUGUET, HELENA, FUTIER, EMMANUEL, GNIADEK, CLAUDINE, VONARB, AURELIE, PRADES, ALBERT, JAILLET, CARINE, CAPDEVILA, XAVIER, CHARBIT, JONATHAN, GENTY, THIBAUT, REZAIGUIA-DELCLAUX, SAIDA, IMBERT, AUDREY, PILORGE, CATHERINE, CALYPSO, ROMAN, BOUTEAU-DURAND, ASTRID, CARLES, MICHEL, MEHDAOUI, HOSSEN, SOUWEINE, BERTRAND, CALVET, LAURE, JABAUDON, MATTHIEU, RIEU, BENJAMIN, CANDILLE, CLARA, SIGAUD, FLORIAN, RIU, BEATRICE, PAPAZIAN, LAURENT, VALERA, SABINE, MOKART, DJAMEL, CHOW CHINE, LAURENT, BISBAL, MAGALI, POULIQUEN, CAMILLE, DE GUIBERT, JEAN-MANUEL, TOURRET, MAXIME, MALLET, DAMIEN, LEONE, MARC, ZIELESKIEWICZ, LAURENT, COSSIC, JEANNE, ASSEFI, MONA, BARON, ELODIE, QUEMENEUR, CYRIL, MONSEL, ANTOINE, BIAIS, MATTHIEU, OUATTARA, ALEXANDRE, BONNARDEL, ELINE, MONZIOLS, SIMON, MAHUL, MARTIN, LEFRANT, JEAN-YVES, ROGER, CLAIRE, BARBAR, SABER, LAMBIOTTE, FABIEN, SAINT-LEGER, PIEHR, PAUGAM, CATHERINE, POTTECHER, JULIEN, LUDES, PIERRE-OLIVIER, DARRIVERE, LUCIE, GARNIER, MARC, KIPNIS, ERIC, LEBUFFE, GILLES, GAROT, MATTHIAS, FALCONE, JEREMY, CHOUSTERMAN, BENJAMIN, COLLET, MAGALI, GAYAT, ETIENNE, DELLAMONICA, JEAN, MFAM, WILLY-SERGE, OCHIN, EVELINA, NEBLI, MOHAMED, TILOUCHE, NEJLA, MADEUX, BENJAMIN, BOUGON, DAVID, AARAB, YASSIR, GARNIER, FANNY, AZOULAY, ELIE, MOLINARI, NICOLAS, JABER, SAMIR, De Jong, Audrey, Bignon, Anne, Stephan, François, Godet, Thomas, Constantin, Jean-Michel, Asehnoune, Karim, Sylvestre, Aude, Sautillet, Juliette, Blondonnet, Raiko, Ferrandière, Martine, Seguin, Philippe, Lasocki, Sigismond, Rollé, Amélie, Fayolle, Pierre-Marie, Muller, Laurent, Pardo, Emmanuel, Terzi, Nicolas, Ramin, Séverin, Jung, Boris, Abback, Paer-Selim, Guerci, Philippe, Sarton, Benjamine, Rozé, Hadrien, Dupuis, Claire, Cousson, Joel, Faucher, Marion, Lemiale, Virginie, Cholley, Bernard, Chanques, Gerald, Belafia, Fouad, Huguet, Helena, Futier, Emmanuel, Azoulay, Elie, Molinari, Nicolas, and Jaber, Samir

Published
2023
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4. ISS is not an appropriate tool to estimate overtriage

Author

Abback, Paër-sélim, Brouns, Kelly, Moyer, Jean-Denis, Holleville, Mathilde, Hego, Camille, Jeantrelle, Caroline, Bout, Hélène, Rennuit, Isabelle, Foucrier, Arnaud, Codorniu, Anaïs, Jurcisin, Igor, Paugam-Burtz, Catherine, and Gauss, Tobias

Published
2022
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5. Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery A post-hoc analysis of a Randomized Clinical Trial

Author

JABER, Samir, primary, Pensier, Joris, additional, Futier, Emmanuel, additional, Paugam-Burtz, Catherine, additional, Seguin, Philippe, additional, Ferrandiere, Martine, additional, Lasocki, Sigismond, additional, Pottecher, Julien, additional, Abback, Paër-Sélim, additional, Riu, Beatrice, additional, Belafia, Fouad, additional, Constantin, Jean-Michel, additional, Verzilli, Daniel, additional, Chanques, Gérald, additional, De Jong, Audrey, additional, and Molinari, Nicolas, additional

Published
2024
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6. Terror in Paris: Incidence and risk factors for infections related to high-energy ammunition injuries

Author

Birnbaum, Ron, Bitton, Rudy, Pirracchio, Romain, Féral-Pierssens, Anne-Laure, Constant, Anne-Laure, Dubost, Clément, Chousterman, Benjamin, Lescot, Thomas, Lortat-Jacob, Brice, Harrois, Anatole, Abback, Paer-Selim, Belbachir, Anissa, Basto, Emmanuel, Castier, Yves, Laitselart, Philippe, Carli, Pierre, Lapostolle, Frédéric, Tourtier, Jean Pierre, Langlois, Matthieu, Raux, Mathieu, and Mounier, Roman

Published
2021
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7. Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study.

Author

Robba, Chiara, Battaglini, Denise, Cinotti, Raphael, Asehnoune, Karim, Stevens, Robert, Taccone, Fabio Silvio, Badenes, Rafael, Pelosi, Paolo, Abback, Paër-sélim, Codorniu, Anaïs, Citerio, Giuseppe, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Agrippino, Bellissima, Filippini, Matteo, and Lazzeri, Nicoletta

Abstract

Background: In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with ABI during the intensive care unit (ICU) stay and to determine their association with in-hospital mortality. The secondary aim was to identify the optimal thresholds of arterial partial pressure of oxygen (PaO2) predicting in-hospital mortality. Methods: We conducted a secondary analysis of a prospective multicenter observational cohort study. Adult patients with ABI (traumatic brain injury, subarachnoid aneurysmal hemorrhage, intracranial hemorrhage, ischemic stroke) with available data on PaO2 during the ICU stay were included. Hypoxemia was defined as PaO2 < 80 mm Hg, normoxemia was defined as PaO2 between 80 and 120 mm Hg, mild/moderate hyperoxemia was defined as PaO2 between 121 and 299 mm Hg, and severe hyperoxemia was defined as PaO2 levels ≥ 300 mm Hg. Results: A total of 1,407 patients were included in this study. The mean age was 52 (±18) years, and 929 (66%) were male. Over the ICU stay, the fractions of patients in the study cohort who had at least one episode of hypoxemia, mild/moderate hyperoxemia, and severe hyperoxemia were 31.3%, 53.0%, and 1.7%, respectively. PaO2 values below 92 mm Hg and above 156 mm Hg were associated with an increased probability of in-hospital mortality. Differences were observed among subgroups of patients with ABI, with consistent effects only seen in patients without traumatic brain injury. Conclusions: In patients with ABI, hypoxemia and mild/moderate hyperoxemia were relatively frequent. Hypoxemia and hyperoxemia during ICU stay may influence in-hospital mortality. However, the small number of oxygen values collected represents a major limitation of the study. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study.

Author

Robba, Chiara, Battaglini, Denise, Abbas, Abbas, Sarrió, Ezequiel, Cinotti, Raphael, Asehnoune, Karim, Taccone, Fabio S., Rocco, Patricia R., Schultz, Marcus J., Citerio, Giuseppe, Stevens, Robert David, Badenes, Rafael, the ENIO collaborators, Abback, Paër-Sélim, Codorniu, Anaïs, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, and Rocco, Monica

Subjects
ARTIFICIAL respiration, CARBON dioxide, INTRACRANIAL hypertension, SECONDARY analysis, INTENSIVE care units
Abstract

Purpose: The use of arterial partial pressure of carbon dioxide (PaCO2) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targets for PaCO2 in acute brain injured (ABI) patients and assess the occurrence of abnormal PaCO2 values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO2 with in-hospital mortality. Methods: We carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO2 was collected on day 1, 3, and 7 from ICU admission. Normocapnia was defined as PaCO2 > 35 and to 45 mmHg; mild hypocapnia as 32–35 mmHg; severe hypocapnia as 26–31 mmHg, forced hypocapnia as < 26 mmHg, and hypercapnia as > 45 mmHg. Results: 1476 patients (65.9% male, mean age 52 ± 18 years) were included. On ICU admission, 804 (54.5%) patients were normocapnic (incidence 1.37 episodes per person/day during ICU stay), and 125 (8.5%) and 334 (22.6%) were mild or severe hypocapnic (0.52 and 0.25 episodes/day). Forced hypocapnia and hypercapnia were used in 40 (2.7%) and 173 (11.7%) patients. PaCO2 had a U-shape relationship with in-hospital mortality with only severe hypocapnia and hypercapnia being associated with increased probability of in-hospital mortality (omnibus p value = 0.0009). Important differences were observed across different subgroups of ABI patients. Conclusions: Normocapnia and mild hypocapnia are common in ABI patients and do not affect patients' outcome. Extreme derangements of PaCO2 values were significantly associated with increased in-hospital mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial

Author

Wahlster, Sarah, Sharma, Monisha, Taran, Shaurya, Town, James A., Stevens, Robert D., Cinotti, Raphaël, Asehoune, Karim, Pelosi, Paolo, Robba, Chiara, Abback, Paër sélim, Codorniu, Anaïs, Citerio, Giuseppe, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Battaglini, Denise, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, van der Jagt, Mathieu, van Steenkiste, Job, Rehabilitation Medicine, Emergency Medicine, Intensive Care, and Internal Medicine

Abstract

Background: There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aimed to describe MP in ventilated patients with ABI, and evaluate associations between MP and clinical outcomes. Methods: In this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult patients with ABI (Glasgow Coma Scale ≤ 12 before intubation) who required mechanical ventilation (MV) ≥ 24 h. Using multivariable log binomial regressions, we separately assessed associations between MP on hospital day (HD)1, HD3, HD7 and clinical outcomes: hospital mortality, need for reintubation, tracheostomy placement, and development of acute respiratory distress syndrome (ARDS). Results: We included 1217 patients (mean age 51.2 years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9 J/min [IQR 9.2–15.1], 13 J/min [IQR 10–17], and 14 J/min [IQR 11–20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9 J/min, aRR at 17 J/min was 1.22, 95% CI 1.14–1.30) and HD3 (1.38, 95% CI 1.23–1.53), reintubation on HD1 (1.64; 95% CI 1.57–1.72), and tracheostomy on HD7 (1.53; 95%CI 1.18–1.99). MP was associated with the development of moderate-severe ARDS on HD1 (2.07; 95% CI 1.56–2.78) and HD3 (1.76; 95% CI 1.41–2.22). Conclusions: Exposure to high MP during the first week of MV is associated with poor clinical outcomes in ABI, independent of P/F ratio and neurological severity. Potential benefits of optimizing ventilator settings to limit MP warrant further investigation.

Published
2023

10. Extubation in neurocritical care patients: the ENIO international prospective study

Author

Cinotti, Raphaël, Mijangos, Julio Cesar, Pelosi, Paolo, Haenggi, Matthias, Gurjar, Mohan, Schultz, Marcus J., Kaye, Callum, Godoy, Daniel Agustin, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Badenes, Rafael, Suei Elbuzidi, Abdurrahmaan Ali, Piagnerelli, Michaël, Elhadi, Muhammed, Reza, Syed Tariq, Azab, Mohammed Atef, McCredie, Victoria, Stevens, Robert D., Digitale, Jean Catherine, Fong, Nicholas, Asehnoune, Karim, Abback, Paër-sélim, Codorniu, Anaïs, Citerio, Giuseppe, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, Battaglini, Denise, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J., Cornet, Alexander Daniel, Inurrigarro, Sergio Reyes, Domínguez, Rafael Cirino Lara, Bellini, Maria Mercedes, Haedo, Maria Milagros Gomez, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronia, Arvind, Miranda-Ackerman, Roberto Carlos, Barbosa-Camacho, Francisco José, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Compagnon, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Yahya, Hana Basheer, Khaled, Ala, Ghula, Mohamed, Andrea, Cracchiolo Neville, Daniela, Palma Maria, Deana, Cristian, Vetrugno, Luigi, Chavez, Manuel J. Rivera, Trujillo, Rocio Mendoza, Legros, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Coombs, Alexander Edward, Welbourne, Jessie, Pineda, Ana Alicia Velarde, Castillo, Víctor Hugo Nubert, Azab, Mohammed A., Azzam, Ahmed Y., van Meenen, David Michael Paul, Gasca, Gilberto Adrian, Arellano, Alfredo, Galicia-Espinosa, Forttino, García-Ramos, José Carlos, Yadav, Ghanshyam, Jha, Amarendra Kumar, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Mishra, Shakti Bedanta, Samal, Samir, Cinotti, R, Mijangos, J, Pelosi, P, Haenggi, M, Gurjar, M, Schultz, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Badenes, R, Suei Elbuzidi, A, Piagnerelli, M, Elhadi, M, Reza, S, Azab, M, Mccredie, V, Stevens, R, Digitale, J, Fong, N, Asehnoune, K, Abback, P, Codorniu, A, Citerio, G, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Robba, C, Battaglini, D, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garcon, P, Zarka, J, Vermeijden, W, Cornet, A, Inurrigarro, S, Dominguez, R, Bellini, M, Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronia, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Compagnon, B, Perez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghula, M, Andrea, C, Daniela, P, Deana, C, Vetrugno, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, Garcia-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Cinotti, Raphaël, Mijangos, Julio Cesar, Pelosi, Paolo, Haenggi, Matthia, Gurjar, Mohan, Schultz, Marcus J., Kaye, Callum, Godoy, Daniel Agustin, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Badenes, Rafael, Suei Elbuzidi, Abdurrahmaan Ali, Piagnerelli, Michaël, Elhadi, Muhammed, Reza, Syed Tariq, Azab, Mohammed Atef, McCredie, Victoria, Stevens, Robert D., Digitale, Jean Catherine, Fong, Nichola, Asehnoune, Karim, Abback, Paër-sélim, Codorniu, Anaï, Citerio, Giuseppe, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, Battaglini, Denise, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Ur, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J., Cornet, Alexander Daniel, Inurrigarro, Sergio Reye, Domínguez, Rafael Cirino Lara, Bellini, Maria Mercede, Haedo, Maria Milagros Gomez, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronia, Arvind, Miranda-Ackerman, Roberto Carlo, Barbosa-Camacho, Francisco José, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thoma, Compagnon, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Yahya, Hana Basheer, Khaled, Ala, Ghula, Mohamed, Andrea, Cracchiolo Neville, Daniela, Palma Maria, Deana, Cristian, Vetrugno, Luigi, Chavez, Manuel J. Rivera, Trujillo, Rocio Mendoza, Legros, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Coombs, Alexander Edward, Welbourne, Jessie, Pineda, Ana Alicia Velarde, Castillo, Víctor Hugo Nubert, Azab, Mohammed A., Azzam, Ahmed Y., van Meenen, David Michael Paul, Gasca, Gilberto Adrian, Arellano, Alfredo, Galicia-Espinosa, Forttino, García-Ramos, José Carlo, Yadav, Ghanshyam, Jha, Amarendra Kumar, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Hossain, Md. Mozaffer, Papadas, Christo, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicola, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicola, Saxena, Sulekha, Agrawal, Avinash, Mishra, Shakti Bedanta, Samal, Samir, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, ACS - Diabetes & metabolism, and ACS - Microcirculation

Subjects
Intensive Care Units, Tracheostomy, Traumatic brain injury, Extubation, Airway Extubation, Humans, Prospective Studies, Brain injury, Critical Care and Intensive Care Medicine, Intra-cranial haemorrhage, Respiration, Artificial
Abstract

Purpose: Neurocritical care patients receive prolonged invasive mechanical ventilation (IMV), but there is poor specific information in this high-risk population about the liberation strategies of invasive mechanical ventilation. Methods: ENIO (NCT03400904) is an international, prospective observational study, in 73 intensive care units (ICUs) in 18 countries from 2018 to 2020. Neurocritical care patients with a Glasgow Coma Score (GCS) ≤ 12, receiving IMV ≥ 24h, undergoing extubation attempt or tracheostomy were included. The primary endpoint was extubation failure by day 5. An extubation success prediction score was created, with 2/3 of patients randomly allocated to the training cohort and 1/3 to the validation cohort. Secondary endpoints were the duration of IMV and in-ICU mortality. Results: 1512 patients were included. Among the 1193 (78.9%) patients who underwent an extubation attempt, 231 (19.4%) failures were recorded. The score for successful extubation prediction retained 20 variables as independent predictors. The area under the curve (AUC) in the training cohort was 0.79 95% confidence interval (CI95) [0.71–0.87] and 0.71 CI95 [0.61–0.81] in the validation cohort. Patients with extubation failure displayed a longer IMV duration (14 [7–21] vs 6 [3–11] days) and a higher in-ICU mortality rate (8.7% vs 2.4%). Three hundred and nineteen (21.1%) patients underwent tracheostomy without extubation attempt. Patients with direct tracheostomy displayed a longer duration of IMV and higher in-ICU mortality than patients with an extubation attempt (success and failure). Conclusions: In neurocritical care patients, extubation failure is high and is associated with unfavourable outcomes. A score could predict extubation success in multiple settings. However, it will be mandatory to validate our findings in another prospective independent cohort.

Published
2022

11. Risk factors of extubation failure in neurocritical patients with the most impaired consciousness.

Author

de Courson, Hugues, Massart, Nicolas, Asehnoune, Karim, Cinotti, Raphaël, Abback, Paër-sélim, Codorniu, Anaïs, Citerio, Giuseppe, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, and Battaglini, Denise

Subjects
EXTUBATION, INTENSIVE care units, CONSCIOUSNESS, COUGH
Abstract

More than 20 years ago, Coplin et al. [[3]] described that the extubation failure rate was similar in patients with or without impaired consciousness [[3]], suggesting that impaired consciousness is not incompatible with extubation attempt. In this subgroup, the extubation failure rate was 25.9% (90 patients) and was significantly higher than in patients with preserved consciousness (19.6%, I p = i 0.02). We performed a post hoc analysis of the ENIO study [[2]], to identify the risk factors associated with extubation failure in patients with the most impaired level of consciousness, defined as a mGCS <= 5 on the day of extubation. [Extracted from the article]

Published
2023
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12. Long-Term Outcome of Severe Metabolic Acidemia in ICU Patients, a BICAR-ICU Trial Post Hoc Analysis.

Author

Bendiab, Eddine, Garnier, Fanny, Soler, Marion, Fosset, Maxime, Jaber, Samir, Molinari, Nicolas, Jung, Boris, de Jong, Audrey, Belafia, Fouad, Chanques, Gérald, Monnin, Marion, Delay, Jean-Marc, Cissé, Moussa, Geniez, Marie, Conseil, Matthieu, Souche, Bruno, Paugam, Catherine, Abback, Paër-Sélim, Futier, Emmanuel, and Michel Constantin, Jean

Published
2023
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13. Multiple Trauma in Pregnant Women: Injury Assessment, Fetal Radiation Exposure and Mortality. A Multicentre Observational Study.

Author

Abback, Paër-sélim, primary, Benchetrit, Alison, additional, Delhaye, nathalie, additional, Daire, Jean-Luc, additional, James, Arthur, additional, Neuschwander, Arthur, additional, Boutonnet, Mathieu, additional, Cook, Fabrice, additional, Vinour, Hélène, additional, Hanouz, Jean-Luc, additional, Cotte, Jean, additional, Pastene, Bruno, additional, Jouffroy, Virdiana, additional, and Gauss, Tobias, additional

Published
2022
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14. Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery: A Randomized Clinical Trial

Author

Jaber, Samir, Lescot, Thomas, Futier, Emmanuel, Paugam-Burtz, Catherine, Seguin, Philippe, Ferrandiere, Martine, Lasocki, Sigismond, Mimoz, Olivier, Hengy, Baptiste, Sannini, Antoine, Pottecher, Julien, Abback, Paër-Sélim, Riu, Beatrice, Belafia, Fouad, Constantin, Jean-Michel, Masseret, Elodie, Beaussier, Marc, Verzilli, Daniel, De Jong, Audrey, Chanques, Gerald, Brochard, Laurent, and Molinari, Nicolas

Published
2016
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15. Correction: Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study.

Author

Robba, Chiara, Battaglini, Denise, Abbas, Abbas, Sarrió, Ezequiel, Cinotti, Raphael, Asehnoune, Karim, Taccone, Fabio S., Rocco, Patricia R., Schultz, Marcus J., Citerio, Giuseppe, Stevens, Robert David, Badenes, Rafael, the ENIO collaborators, Abback, Paër-Sélim, Codorniu, Anaïs, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, and Rocco, Monica

Subjects
ARTIFICIAL respiration, CARBON dioxide, SECONDARY analysis, INTENSIVE care units
Abstract

This document is a correction notice for an article titled "Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study." The correction addresses mistakes in the acknowledgements section, specifically the misspelling of a name and errors in the affiliations of some authors. The original publication has been corrected. The document also includes a note from the publisher stating their neutrality regarding jurisdictional claims and institutional affiliations. [Extracted from the article]

Published
2024
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16. ISS is not an appropriate tool to estimate overtriage

Author

Abback, Paër-sélim, primary, Brouns, Kelly, additional, Moyer, Jean-Denis, additional, Holleville, Mathilde, additional, Hego, Camille, additional, Jeantrelle, Caroline, additional, Bout, Hélène, additional, Rennuit, Isabelle, additional, Foucrier, Arnaud, additional, Codorniu, Anaïs, additional, Jurcisin, Igor, additional, Paugam-Burtz, Catherine, additional, and Gauss, Tobias, additional

Published
2021
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17. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial

Author

Jaber, Samir, primary, Paugam, Catherine, additional, Futier, Emmanuel, additional, Lefrant, Jean-Yves, additional, Lasocki, Sigismond, additional, Lescot, Thomas, additional, Pottecher, Julien, additional, Demoule, Alexandre, additional, Ferrandière, Martine, additional, Asehnoune, Karim, additional, Dellamonica, Jean, additional, Velly, Lionel, additional, Abback, Paër-Sélim, additional, de Jong, Audrey, additional, Brunot, Vincent, additional, Belafia, Fouad, additional, Roquilly, Antoine, additional, Chanques, Gérald, additional, Muller, Laurent, additional, Constantin, Jean-Michel, additional, Bertet, Helena, additional, Klouche, Kada, additional, Molinari, Nicolas, additional, Jung, Boris, additional, Jaber, Samir, additional, Monnin, Marion, additional, Delay, Jean-Marc, additional, Cissé, Moussa, additional, Geniez, Marie, additional, Conseil, Matthieu, additional, Souche, Bruno, additional, Constantin, Jean Michel, additional, Noll, Eric, additional, Morawiec, Elise, additional, Robert, Alexandre, additional, Triglia, Thibaut, additional, Mechati, Malika, additional, Arnal, Jean-Michel, additional, Durand-Gasselin, Jacques, additional, Demoly, Didier, additional, Hraiech, Sami, additional, Papazian, Laurent, additional, Gilles, Vincent, additional, Rimmelé, Thomas, additional, Riu, Béatrice, additional, Cougot, Pierre, additional, Fourcade, Olivier, additional, Seguin, Philippe, additional, Charbit, Jonathan, additional, Capdevila, Xavier, additional, Leone, Marc, additional, Zieleskiewicz, Laurent, additional, Ichai, Carole, additional, Orban, Jean Christophe, additional, Darmon, Michael, additional, Azoulay, Elie, additional, Lemiale, Virginie, additional, Zafrani, Lara, additional, Debbat, Karim, additional, Mimoz, Oliver, additional, Guérin, Claude, additional, and Kipnis, Eric, additional

Published
2018
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22. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial.

Author

Jaber, Samir, Paugam, Catherine, Futier, Emmanuel, Lefrant, Jean-Yves, Lasocki, Sigismond, Lescot, Thomas, Pottecher, Julien, Demoule, Alexandre, Ferrandière, Martine, Asehnoune, Karim, Dellamonica, Jean, Velly, Lionel, Abback, Paër-Sélim, de Jong, Audrey, Brunot, Vincent, Belafia, Fouad, Roquilly, Antoine, Chanques, Gérald, Muller, Laurent, and Constantin, Jean-Michel

Subjects
*SODIUM bicarbonate, *ACIDOSIS, *INTENSIVE care patients, *LACTATES, *MORTALITY, *THERAPEUTICS, *HEMORRHAGIC shock treatment, *AMBULANCES, *BLOOD plasma, *COMPARATIVE studies, *EMERGENCY medical services, *HEMORRHAGIC shock, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *RESEARCH funding, *RESUSCITATION, *SALT, *SURVIVAL, *TRAUMA centers, *EVALUATION research
Abstract

Background: Plasma is integral to haemostatic resuscitation after injury, but the timing of administration remains controversial. Anticipating approval of lyophilised plasma by the US Food and Drug Administration, the US Department of Defense funded trials of prehospital plasma resuscitation. We investigated use of prehospital plasma during rapid ground rescue of patients with haemorrhagic shock before arrival at an urban level 1 trauma centre.Methods: The Control of Major Bleeding After Trauma Trial was a pragmatic, randomised, single-centre trial done at the Denver Health Medical Center (DHMC), which houses the paramedic division for Denver city. Consecutive trauma patients in haemorrhagic shock (defined as systolic blood pressure [SBP] ≤70 mm Hg or 71-90 mm Hg plus heart rate ≥108 beats per min) were assessed for eligibility at the scene of the injury by trained paramedics. Eligible patients were randomly assigned to receive plasma or normal saline (control). Randomisation was achieved by preloading all ambulances with sealed coolers at the start of each shift. Coolers were randomly assigned to groups 1:1 in blocks of 20 according to a schedule generated by the research coordinators. If the coolers contained two units of frozen plasma, they were defrosted in the ambulance and the infusion started. If the coolers contained a dummy load of frozen water, this indicated allocation to the control group and saline was infused. The primary endpoint was mortality within 28 days of injury. Analyses were done in the as-treated population and by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT01838863.Findings: From April 1, 2014, to March 31, 2017, paramedics randomly assigned 144 patients to study groups. The as-treated analysis included 125 eligible patients, 65 received plasma and 60 received saline. Median age was 33 years (IQR 25-47) and median New Injury Severity Score was 27 (10-38). 70 (56%) patients required blood transfusions within 6 h of injury. The groups were similar at baseline and had similar transport times (plasma group median 19 min [IQR 16-23] vs control 16 min [14-22]). The groups did not differ in mortality at 28 days (15% in the plasma group vs 10% in the control group, p=0·37). In the intention-to-treat analysis, we saw no significant differences between the groups in safety outcomes and adverse events. Due to the consistent lack of differences in the analyses, the study was stopped for futility after 144 of 150 planned enrolments.Interpretation: During rapid ground rescue to an urban level 1 trauma centre, use of prehospital plasma was not associated with survival benefit. Blood products might be beneficial in settings with longer transport times, but the financial burden would not be justified in an urban environment with short distances to mature trauma centres.Funding: US Department of Defense. [ABSTRACT FROM AUTHOR]

Published
2018
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