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2. Delirium Incidence and Predictors in SARS-CoV-2 Vaccinated Residents in Long-Term Care Facilities (LTCF): Insights from the GeroCovid Vax Study

Author

Okoye, Chukwuma, Zazzara, Maria Beatrice, Ceolin, Chiara, Fedele, Giorgio, Palmieri, Annapina, Abbatecola, Angela Marie, Malara, Alba, Trevisan, Caterina, Timmons, Suzanne, Prato, Rosa, Fortunato, Francesca, Del Signore, Susanna, Bellelli, Giuseppe, Incalzi, Raffaele Antonelli, Onder, Graziano, and Coin, Alessandra

Published
2024
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6. An Overall Automated Architecture Based on the Tapping Test Measurement Protocol: Hand Dexterity Assessment through an Innovative Objective Method.

Author

Di Libero, Tommaso, Carissimo, Chiara, Cerro, Gianni, Abbatecola, Angela Marie, Marino, Alessandro, Miele, Gianfranco, Ferrigno, Luigi, and Rodio, Angelo

Subjects
FINE motor ability, MOTOR ability, PHYSICIANS, WORK measurement, NEURODEGENERATION
Abstract

The present work focuses on the tapping test, which is a method that is commonly used in the literature to assess dexterity, speed, and motor coordination by repeatedly moving fingers, performing a tapping action on a flat surface. During the test, the activation of specific brain regions enhances fine motor abilities, improving motor control. The research also explores neuromuscular and biomechanical factors related to finger dexterity, revealing neuroplastic adaptation to repetitive movements. To give an objective evaluation of all cited physiological aspects, this work proposes a measurement architecture consisting of the following: (i) a novel measurement protocol to assess the coordinative and conditional capabilities of a population of participants; (ii) a suitable measurement platform, consisting of synchronized and non-invasive inertial sensors to be worn at finger level; (iii) a data analysis processing stage, able to provide the final user (medical doctor or training coach) with a plethora of useful information about the carried-out tests, going far beyond state-of-the-art results from classical tapping test examinations. Particularly, the proposed study underscores the importance interdigital autonomy for complex finger motions, despite the challenges posed by anatomical connections; this deepens our understanding of upper limb coordination and the impact of neuroplasticity, holding significance for motor abilities assessment, improvement, and therapeutic strategies to enhance finger precision. The proof-of-concept test is performed by considering a population of college students. The obtained results allow us to consider the proposed architecture to be valuable for many application scenarios, such as the ones related to neurodegenerative disease evolution monitoring. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Contributors

Author

Abbatecola, Angela Marie, primary, Abdellatif, Ahmed, additional, Abrahams, Shameemah, additional, Almey, Anne, additional, Artan, Sevilhan, additional, Attia, Hamdino, additional, Ausin, Karina, additional, Bardien, Soraya, additional, Bareš, Martin, additional, Bekker, Minke, additional, Belagodu, Amogh, additional, Bellomo, Antonello, additional, Belova, Olga A., additional, Beltrán-Castillo, Sebastián, additional, Białecka-De¸bek, Agata, additional, Binda, Karina Henrique, additional, Blumberger, Daniel M., additional, Boccardi, Mariangela, additional, Boccardi, Virginia, additional, Boros, Benjamin D., additional, Bors, Luca Anna, additional, Bortolami, Alessandro, additional, Bowie, Daniel C., additional, Bruno, Francesca, additional, Caramelli, Paulo, additional, Cardona-Gómez, G.P., additional, Carr, Jonathan, additional, Cartas-Cejudo, Paz, additional, Casadesus, Gemma, additional, Clements, Grace M., additional, Cuttler, Katelyn, additional, Daniele, Antonio, additional, Daskalakis, Zafiris J., additional, Dibello, Vittorio, additional, Di Rosa, Michelino, additional, D’Agata, Velia, additional, D’Amico, Agata Grazia, additional, du Toit, Andre, additional, Ebrahimi-Mameghani, Mehrangiz, additional, Eggen, B.J.L., additional, Ekpo, Okobi, additional, Erdő, Franciska, additional, Erickson, Kirk I., additional, Erzurumluoglu Gokalp, Ebru, additional, Escobar, Kurt A., additional, Eugenín, Jaime, additional, Fabiani, Monica, additional, Farghali, Mahitab, additional, Federico, Concetta, additional, Fernández-Irigoyen, Joaquín, additional, Ferrari, Federica, additional, Ferrer, Isidro, additional, Filip, Pavel, additional, Fraga, Vanêssa Gomes, additional, Furuse, Mitsuhiro, additional, Galvez, Roberto, additional, Gardener, Samantha L., additional, Gervais, Nicole J., additional, Giannelli, Gianluigi, additional, Gil, Laura, additional, Gomes, Karina Braga, additional, González-Morales, Andrea, additional, Graham, Stuart L., additional, Gratton, Gabriele, additional, Greco, Antonio, additional, Grigoriev, Andrey, additional, Gu, Yian, additional, Guan, Lingyu, additional, Gulley, Joshua M., additional, Gupta, Vivek K., additional, Herskowitz, Jeremy H., additional, Jinno, Shozo, additional, Jonasson, Lars Stiernman, additional, Jové, Mariona, additional, Kang, Shuo, additional, Kelly, Michy P., additional, Kinno, Ryuta, additional, Knyazeva, Maria G., additional, Koh, Joanne, additional, Koini, Marisa, additional, Komleva, Yulia K., additional, Lachén-Montes, Mercedes, additional, La Montagna, Maddalena, additional, Landau, Anne Marlene, additional, Lauretani, Fulvio, additional, Li, Ran, additional, Li, Yuandong, additional, Li, Xuan, additional, Lissemore, Jennifer I., additional, Loos, Ben, additional, Lopatina, Olga L., additional, Lozupone, Madia, additional, MacLean, Andrew G., additional, Maduna, Tando, additional, Maggio, Marcello, additional, Majdi, Alireza, additional, Manan, Hanani Abdul, additional, Marfella, Raffaele, additional, Maugeri, Grazia, additional, Mendizuri, Naroa, additional, Mey, Megan, additional, Mizutani, Kiyohito, additional, Molinari, Claudio, additional, Morsanuto, Vera, additional, Mota-Martorell, Natalia, additional, Navakkode, Sheeja, additional, Nicoll, Gina, additional, Ono, Kenjiro, additional, Ozbabalik Adapinar, Demet, additional, Pamplona, Reinald, additional, Panza, Francesco, additional, Peterson, Tiffany A., additional, Pradas, Irene, additional, Preedy, Victor R., additional, Rainey-Smith, Stephanie R., additional, Real, Caroline Cristiano, additional, Rendeiro, Catarina, additional, Rhodes, Justin S., additional, Rogerson, Georgia A.F., additional, Ruga, Sara, additional, Saccone, Salvatore, additional, Sadigh-Eteghad, Saeed, additional, Salmin, Vladimir V., additional, Salmina, Alla B., additional, Sanayei, Mahzad, additional, Sanfilippo, Cristina, additional, Santamaría, Enrique, additional, Sardone, Rodolfo, additional, Schatten, Heide, additional, Seripa, Davide, additional, Sesti, Federico, additional, Shen, Ting, additional, Solfrizzi, Vincenzo, additional, Soong, Tuck Wah, additional, Starnawska, Anna, additional, Staunstrup, Nicklas Heine, additional, Stillman, Chelsea, additional, Sturiale, Valentina, additional, Takai, Yoshimi, additional, Turner, Dennis A., additional, Uberti, Francesca, additional, Vaghef-Mehrabany, Elnaz, additional, Vaghef-Mehrabany, Leila, additional, VanDusseldorp, Trisha A., additional, Villa, Roberto Federico, additional, Villamil-Ortiz, J., additional, von Bernhardi, Rommy, additional, Wang, Ruikang K., additional, Wengle, Lauren, additional, Wu, Yu-Chien, additional, Yahya, Noorazrul Azmie, additional, Yamada, Jun, additional, Yang, Wei, additional, You, Yuyi, additional, Yusoff, Ahmad Nazlim, additional, and Zhai, Jing, additional

Published
2021
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9. Promoting and Building Long-Term Care Health Research Networks: GeroCovid Observational and Gerocovid Vax Initiatives

Author

Abbatecola, Angela Marie, primary, Abbatecola, Angela Marie, additional, Incalzi, Raffaele Antonelli, additional, Bellelli, Giuseppe, additional, Borselli, Gilda, additional, Cafariello, Carmine, additional, Coin, Alessandra, additional, Del Signore, Stefania, additional, Del Signore, Susanna, additional, Fumagalli, Stefano, additional, Gareri, Pietro, additional, Malara, Alba, additional, Mossello, Enrico, additional, Monzani, Fabio, additional, Noale, Marianna, additional, Okoye, Chukwuma, additional, Onder, Graziano, additional, Trevisan, Caterina, additional, Volpato, Stefano, additional, and Zia, Gianluca, additional

Published
2023
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10. Sarcopenia with limited mobility: an international consensus.

Author

Morley, John E, Abbatecola, Angela Marie, Argiles, Josep M, Baracos, Vickie, Bauer, Juergen, Bhasin, Shalender, Cederholm, Tommy, Coats, Andrew J Stewart, Cummings, Steven R, Evans, William J, Fearon, Kenneth, Ferrucci, Luigi, Fielding, Roger A, Guralnik, Jack M, Harris, Tamara B, Inui, Akio, Kalantar-Zadeh, Kamyar, Kirwan, Bridget-Anne, Mantovani, Giovanni, Muscaritoli, Maurizio, Newman, Anne B, Rossi-Fanelli, Filippo, Rosano, Giuseppe MC, Roubenoff, Ronenn, Schambelan, Morris, Sokol, Gerald H, Storer, Thomas W, Vellas, Bruno, von Haehling, Stephan, Yeh, Shing-Shing, Anker, Stefan D, and Society on Sarcopenia, Cachexia and Wasting Disorders Trialist Workshop

Subjects
Society on Sarcopenia, Cachexia and Wasting Disorders Trialist Workshop, Muscle, Skeletal, Humans, Consensus, Internationality, Aged, Middle Aged, Female, Male, Mobility Limitation, Sarcopenia, Stem Cell Research, Aging, Clinical Research, Musculoskeletal, Geriatrics, Clinical Sciences, Nursing, Public Health and Health Services
Abstract

A consensus conference convened by the Society of Sarcopenia, Cachexia and Wasting Disorders has concluded that "Sarcopenia, ie, reduced muscle mass, with limited mobility" should be considered an important clinical entity and that most older persons should be screened for this condition. "Sarcopenia with limited mobility" is defined as a person with muscle loss whose walking speed is equal to or less than 1 m/s or who walks less than 400 m during a 6-minute walk, and who has a lean appendicular mass corrected for height squared of 2 standard deviations or more below the mean of healthy persons between 20 and 30 years of age of the same ethnic group. The limitation in mobility should not clearly be a result of otherwise defined specific diseases of muscle, peripheral vascular disease with intermittent claudication, central and peripheral nervous system disorders, or cachexia. Clinically significant interventions are defined as an increase in the 6-minute walk of at least 50 meters or an increase of walking speed of at least 0.1 m/s.

Published
2011

12. Efficacy of COVID-19 control measures on post-vaccination outbreak in Italian Long Term Care Facilities: implications for policies

Author

Malara, Alba, Noale, Marianna, Trevisan, Caterina, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Gareri, Pietro, Fumagalli, Stefano, Mossello, Enrico, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Okoye, Chukwuma, Bellelli, Giuseppe, Del Signore, Stefania, Zia, Gianluca, Antonelli Incalzi, Raffaele, Palmieri, Annapina, Fedele, Giorgio, Onder, Graziano, Malara, A, Noale, M, Trevisan, C, Abbatecola, A, Borselli, G, Cafariello, C, Gareri, P, Fumagalli, S, Mossello, E, Volpato, S, Monzani, F, Coin, A, Okoye, C, Bellelli, G, Del Signore, S, Zia, G, Antonelli Incalzi, R, Palmieri, A, Fedele, G, and Onder, G

Subjects
COVID-19 vaccination, pandemic fatigue, outbreak control measure, Public Health, Environmental and Occupational Health, SARS CoV-2 infection, Long Term Care Facilities (LTCFS)
Abstract

BackgroundNumerous individual and organizational factors can influence the spread of SARS-CoV-2 infection in Long Term Care Facilities (LTCFs). A range of outbreak control measures are still implemented in most facilities involving administrations, staff, residents and their families. This study aims to evaluate which measure could influence the transmission of SARS-CoV-2 infection among residents during the period March 2021-June 2022. MethodsWe enrolled 3,272 residents aged >= 60 years. The outbreak control measures adopted to prevent or manage the infection included entry regulations, contact-regulating procedures, and virological surveillance of residents and staff. The association between LTCFs' and participants' characteristics with new cases of COVID-19 infections was analyzed using multilevel logistic regression models. ResultsIn 33.8% of the facilities 261 cases of SARS-CoV-2 infection were reported. Among participant characteristics, gender and age were not associated with SARS-CoV-2 infection, while having received the vaccine booster dose was protective against infection [Odds Ratio (OR) = 0.34, 95% Confidence Interval (CI) 0.12-0.99, p = 0.048]. In addition, the implementation of protected areas for family visits was associated with a significant reduction of the probability of infections (OR = 0.18, 95% CI 0.03-0.98, p = 0.047). Overall, about 66% of the variability in the probability of SARS-CoV-2 infection during the observational period may be due to facility structure characteristics and 34% to the participant characteristics. ConclusionsThese data showed that vaccination booster doses and family visit restriction-control are still needed to make the LTCFs safer against SARS-CoV-2 infection.

Published
2023

14. COVID-19 Signs and Symptom Clusters in Long-Term Care Facility Residents: Data from the GeroCovid Observational Study

Author

Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, Incalzi, R, Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Stefania, Zia, Gianluca, Incalzi, Raffaele Antonelli, Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, Incalzi, R, Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Stefania, Zia, Gianluca, and Incalzi, Raffaele Antonelli

Abstract

Background: Long-term care facility (LTCF) residents often present asymptomatic or paucisymptomatic features of SARS-CoV-2 infection. We aimed at investigating signs/symptoms, including their clustering on SARS-CoV-2 infection and mortality rates associated with SARS-CoV-2 infection in LTCF residents. Methods: This is a cohort study of 586 aged ≥ 60 year-old residents at risk of or affected with COVID-19 enrolled in the GeroCovid LTCF network. COVID-19 signs/symptom clusters were identified using cluster analysis. Cluster analyses associated with SARS-CoV-2 infection and mortality were evaluated using logistic regression and Cox proportional hazard models. Results: Cluster 1 symptoms (delirium, fever, low-grade fever, diarrhea, anorexia, cough, increased respiratory rate, sudden deterioration in health conditions, dyspnea, oxygen saturation, and weakness) affected 39.6% of residents and were associated with PCR swab positivity (OR = 7.21, 95%CI 4.78–10.80; p < 0.001). Cluster 1 symptoms were present in deceased COVID-19 residents. Cluster 2 (increased blood pressure, sphincter incontinence) and cluster 3 (new-onset cognitive impairment) affected 20% and 19.8% of residents, respectively. Cluster 3 symptoms were associated with increased mortality (HR = 5.41, 95%CI 1.56–18.8; p = 0.008), while those of Cluster 2 were not associated with mortality (HR = 0.82, 95%CI 0.26–2.56; p = 730). Conclusions: Our study highlights that delirium, fever, and low-grade fever, alone or in clusters should be considered in identifying and predicting the prognosis of SARS-CoV-2 infection in older LTCF patients.

Published
2022

15. Clinical Features of SARS-CoV-2 Infection in Italian Long-Term Care Facilities: GeroCovid LTCFs Observational Study

Author

Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, Antonelli Incalzi, R, Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Susanna, Zia, Gianluca, Antonelli Incalzi, Raffaele, Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, Antonelli Incalzi, R, Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Susanna, Zia, Gianluca, and Antonelli Incalzi, Raffaele

Published
2022

16. Monitoring COVID-19 vaccine use in Italian long term care centers: The GeroCovid VAX study

Author

Abbatecola, Angela Marie, primary, Incalzi, Raffaele Antonelli, additional, Malara, Alba, additional, Palmieri, Annapina, additional, Di Lonardo, Anna, additional, Fedele, Giorgio, additional, Stefanelli, Paola, additional, Borselli, Gilda, additional, Russo, Marcello, additional, Noale, Marianna, additional, Fumagalli, Stefano, additional, Gareri, Pietro, additional, Mossello, Enrico, additional, Trevisan, Caterina, additional, Volpato, Stefano, additional, Monzani, Fabio, additional, Coin, Alessandra, additional, Bellelli, Giuseppe, additional, Okoye, Chukwuma, additional, Del Signore, Susanna, additional, Zia, Gianluca, additional, Bottoni, Elisa, additional, Cafariello, Carmine, additional, and Onder, Graziano, additional

Published
2022
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17. COVID-19 Signs and Symptom Clusters in Long-Term Care Facility Residents: Data from the GeroCovid Observational Study

Author

Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Stefania, Zia, Gianluca, Incalzi, Raffaele Antonelli, Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, and Incalzi, R

Subjects
gerocovid observational study, symptoms cluster, COVID-19, Electrical and Electronic Engineering, long term care facilitie, Atomic and Molecular Physics, and Optics, long term care facilities
Abstract

Background: Long-term care facility (LTCF) residents often present asymptomatic or paucisymptomatic features of SARS-CoV-2 infection. We aimed at investigating signs/symptoms, including their clustering on SARS-CoV-2 infection and mortality rates associated with SARS-CoV-2 infection in LTCF residents. Methods: This is a cohort study of 586 aged ≥ 60 year-old residents at risk of or affected with COVID-19 enrolled in the GeroCovid LTCF network. COVID-19 signs/symptom clusters were identified using cluster analysis. Cluster analyses associated with SARS-CoV-2 infection and mortality were evaluated using logistic regression and Cox proportional hazard models. Results: Cluster 1 symptoms (delirium, fever, low-grade fever, diarrhea, anorexia, cough, increased respiratory rate, sudden deterioration in health conditions, dyspnea, oxygen saturation, and weakness) affected 39.6% of residents and were associated with PCR swab positivity (OR = 7.21, 95%CI 4.78–10.80; p < 0.001). Cluster 1 symptoms were present in deceased COVID-19 residents. Cluster 2 (increased blood pressure, sphincter incontinence) and cluster 3 (new-onset cognitive impairment) affected 20% and 19.8% of residents, respectively. Cluster 3 symptoms were associated with increased mortality (HR = 5.41, 95%CI 1.56–18.8; p = 0.008), while those of Cluster 2 were not associated with mortality (HR = 0.82, 95%CI 0.26–2.56; p = 730). Conclusions: Our study highlights that delirium, fever, and low-grade fever, alone or in clusters should be considered in identifying and predicting the prognosis of SARS-CoV-2 infection in older LTCF patients.

Published
2022

18. Clinical Features of SARS-CoV-2 Infection in Italian Long-Term Care Facilities: GeroCovid LTCFs Observational Study

Author

Abbatecola, Angela Marie, Addamo, Francesco Raffaele, Andrieri, Domenico, Antognoli, Rachele, Bianchi, Paola, Cafariello, Carmine, Calsolaro, Valeria, Campagna, Francesco Antonio, Capurso, Sebastiano, Carino, Silvia, Castelli, Manuela, Ceretti, Arcangelo, Colombo, Mauro, Crispino, Antonella, Cucunato, Roberta, D'Amico, Ferdinando, Dell'Armi, Annalaura, Ferro, Christian, Fiorillo, Serafina, Gasbarri, Pier Paolo, Granata, Roberta, Grillo, Nadia, Guaita, Antonio, Iarrera, Marilena, Ippolito, Valerio Alex, Malara, Alba, Mancuso, Irene, Marelli, Eleonora, Moneti, Paolo, Monzani, Fabio, Noale, Marianna, Osso, Sara, Perri, Agostino, Perticone, Maria, Romaniello, Carmine, Russo, Marcello, Sgrò, Giovanni, Sirianni, Federica, Spaccaferro, Deborah, Spadea, Fausto, Ursino, Rita, Borselli, Gilda, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Susanna, Zia, Gianluca, and Antonelli Incalzi, Raffaele

Published
2022
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19. Clinical Features of SARS-CoV-2 Infection in Italian Long-Term Care Facilities: GeroCovid LTCFs Observational Study

Author

Malara, Alba, primary, Noale, Marianna, additional, Abbatecola, Angela Marie, additional, Borselli, Gilda, additional, Cafariello, Carmine, additional, Fumagalli, Stefano, additional, Gareri, Pietro, additional, Mossello, Enrico, additional, Trevisan, Caterina, additional, Volpato, Stefano, additional, Monzani, Fabio, additional, Coin, Alessandra, additional, Bellelli, Giuseppe, additional, Okoye, Chukwuma, additional, Del Signore, Susanna, additional, Zia, Gianluca, additional, Antonelli Incalzi, Raffaele, additional, Addamo, Francesco Raffaele, additional, Andrieri, Domenico, additional, Antognoli, Rachele, additional, Bianchi, Paola, additional, Calsolaro, Valeria, additional, Campagna, Francesco Antonio, additional, Capurso, Sebastiano, additional, Carino, Silvia, additional, Castelli, Manuela, additional, Ceretti, Arcangelo, additional, Colombo, Mauro, additional, Crispino, Antonella, additional, Cucunato, Roberta, additional, D'Amico, Ferdinando, additional, Dell'Armi, Annalaura, additional, Ferro, Christian, additional, Fiorillo, Serafina, additional, Gasbarri, Pier Paolo, additional, Granata, Roberta, additional, Grillo, Nadia, additional, Guaita, Antonio, additional, Iarrera, Marilena, additional, Ippolito, Valerio Alex, additional, Malara, Alba, additional, Mancuso, Irene, additional, Marelli, Eleonora, additional, Moneti, Paolo, additional, Osso, Sara, additional, Perri, Agostino, additional, Perticone, Maria, additional, Romaniello, Carmine, additional, Russo, Marcello, additional, Sgrò, Giovanni, additional, Sirianni, Federica, additional, Spaccaferro, Deborah, additional, Spadea, Fausto, additional, and Ursino, Rita, additional

Published
2022
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20. Diabetes Affects Antibody Response to SARS-CoV-2 Vaccination in Older Residents of Long-term Care Facilities: Data From the GeroCovid Vax Study.

Author

Virgilio, Enrico, Trevisan, Caterina, Abbatecola, Angela, Malara, Alba, Palmieri, Annapina, Fedele, Giorgio, Stefanelli, Paola, Leone, Pasqualina, Schiavoni, Ilaria, Maggi, Stefania, Volpato, Stefano, Antonelli Incalzi, Raffaele, Onder, Graziano, AbbatecolaAngela MarieAndrieriDomenicoIncalziRaffaele AntonelliArenareFrancescaBagalàVivianaBaldovinTatjanaBernardiRiccardoBianchiAlessandraBianchiPaolaBiscegliaRaffaellaBissoliIvanBontempiFabioBorselliGildaBottaroLuigiBottoniElisaBrandiSilviaBravinC, Abbatecola, Angela Marie, Andrieri, Domenico, Incalzi, Raffaele Antonelli, Arenare, Francesca, Bagalà, Viviana, and Baldovin, Tatjana

Abstract

OBJECTIVE: Type 2 diabetes may affect the humoral immune response after vaccination, but data concerning coronavirus disease 19 (COVID-19) vaccines are scarce. We evaluated the impact of diabetes on antibody response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in older residents of long-term care facilities (LTCFs) and tested for differences according to antidiabetic treatment. RESEARCH DESIGN AND METHODS: For this analysis, 555 older residents of LTCFs participating in the GeroCovid Vax study were included. SARS-CoV-2 trimeric S immunoglobulin G (anti-S IgG) concentrations using chemiluminescent assays were tested before the first dose and after 2 and 6 months. The impact of diabetes on anti-S IgG levels was evaluated using linear mixed models, which included the interaction between time and presence of diabetes. A second model also considered diabetes treatment: no insulin therapy (including dietary only or use of oral antidiabetic agents) and insulin therapy (alone or in combination with oral antidiabetic agents). RESULTS: The mean age of the sample was 82.1 years, 68.1% were women, and 25.2% had diabetes. In linear mixed models, presence of diabetes was associated with lower anti-S IgG levels at 2 (β = −0.20; 95% CI −0.34, −0.06) and 6 months (β = −0.22; 95% CI −0.37, −0.07) after the first vaccine dose. Compared with those without diabetes, residents with diabetes not using insulin had lower IgG levels at 2- and 6-month assessments (β = −0.24; 95% CI −0.43, −0.05 and β = −0.30; 95% CI −0.50, −0.10, respectively), whereas no differences were observed for those using insulin. CONCLUSIONS: Older residents of LTCFs with diabetes tended to have weaker antibody response to COVID-19 vaccination. Insulin treatment might buffer this effect and establish humoral immunity similar to that in individuals without diabetes. [ABSTRACT FROM AUTHOR]

Published
2022
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21. List of Contributors

Author

Abbatecola, Angela Marie, primary, Abe, Koji, additional, Abisambra, Jose F., additional, Ahmad, Aliya, additional, Alaei, Hojjatollah, additional, Alagiakrishnan, Kannayiram, additional, Aliev, Gjumrakch, additional, Allegri, Ricardo Francisco, additional, Almeida, Osvaldo P., additional, Álvarez-Cervera, Fernando J., additional, Alwi, Nor Amalina Ahmad, additional, Ames, David, additional, Anderson-Mooney, Amelia Jane, additional, Andrade, José Paulo, additional, Anglés, Neus, additional, Armstrong, R.A., additional, Assunção, Marco, additional, Atteia, Hebatallah Husseini, additional, Avila, Marco Fidel, additional, Bair, Ming-Jong, additional, Barbagallo, Mario, additional, Barberger-Gateau, Pascale, additional, Barbieri, Michelangela, additional, Barreto, George E., additional, Bata-García, José L., additional, Begum, Monirun, additional, Bellia, Francesco, additional, Belvedere, Mario, additional, Bennett, Louise E., additional, Białecka, Monika, additional, Bird, Michael, additional, Blundo, Carlo, additional, Boccardi, Virginia, additional, Bolea, Irene, additional, Bosco, Domenico, additional, Brouwer-Brolsma, Elske M., additional, Brust, John C.M., additional, Buffa, Roberto, additional, Bunner, Kendra D., additional, Burri, Lena, additional, Cabezas, Ricardo, additional, Camina, María Alicia, additional, Campbell, Tessa N., additional, Cano, Lourdes Rexach, additional, Chen, Huan-Lin, additional, Chen, Jianmin, additional, Cheung, David Wing-Shing, additional, Choy, Francis Y.M., additional, Chua, J., additional, Colica, Carmen, additional, Corcia, Philippe, additional, Craft, Suzanne, additional, Cristiano, Dario, additional, Cusimano, Michael D., additional, Dalton, Kate, additional, Davidson, Terry L., additional, De Bartolo, Matteo, additional, de Bem, Andreza Fabro, additional, de Castro, Isac, additional, de Groot, Lisette C.P.G.M., additional, de la Cruz Marcos, Sandra, additional, de Oliveira, Jade, additional, del Balzo, Valeria, additional, Deguchi, Kentaro, additional, Deguchi, Shoko, additional, Deth, Richard, additional, Dominguez, Ligia J., additional, Donini, Lorenzo M., additional, Doruk, Huseyin, additional, Dziewas, Rainer, additional, Díes, Rafael Carles, additional, El-Bachá, Ramon Santos, additional, El-Swefy, Sahar Elsayed, additional, Enciso, Laura Carreño, additional, Ermio, Caterina, additional, Escribano, Begoña M., additional, Estrada-Sánchez, Ana María, additional, Etgen, Thorleif, additional, Farina, Marcelo, additional, Fava, Antonietta, additional, Feart, Catherine, additional, Feng, Lei, additional, Fernández-Fernández, Laura, additional, Ferreira, Danilio Alvear Sampaio, additional, Fiala, Milan, additional, Fialdini, Renata Caruso, additional, Fisher, Cheryl, additional, Galimberti, Daniela, additional, Galvin, James E., additional, Gelber, Rebecca P., additional, Gerace, Carmela, additional, Giannakopoulos, Panteleimon, additional, Giannopoulos, Phillip F., additional, Giridharan, Vijayasree V., additional, Giusti, Anna Maria, additional, Gonzalez, Janneth, additional, Góngora-Alfaro, José L., additional, Gordon, Paul H., additional, Greiwe, Jeffrey S., additional, Grima, Natalie A., additional, Guedes, Rubem, additional, Gupta, Susham, additional, Gyengesi, Erika, additional, Haller, Sven, additional, Hanson, Angela J., additional, Harvey, Jenni, additional, Hassan, Ossama Morsi, additional, Henderson, Samuel T., additional, Herrup, Karl, additional, Hickey, M.A., additional, Hoerr, Robert, additional, Hou, Xiaoli, additional, Huang, Chengyu, additional, Hügel, Helmut M., additional, Hwang, Sam-Long, additional, Ikeda, Yoshio, additional, Irie, Kazuhiro, additional, Jack, Alexandria, additional, Jackson, Neale, additional, Jackson, Richard L., additional, Jannise, Brittany, additional, Jiang, Yugang, additional, Johnson, C.Shanthi, additional, Jolliff, James S., additional, Jové, Mariona, additional, Kam, Jonathan S., additional, Kanoski, Scott E., additional, Khan, Khurshid, additional, Kimura, Takemi, additional, Kitagishi, Yasuko, additional, Konishi, Tetsuya, additional, Kovacs, Gabor G., additional, Krause, Debra, additional, Kua, Ee-Heok, additional, Kurata, Tomoko, additional, Kurian, Mini, additional, Kwok, Timothy, additional, Lam, Wai Ping, additional, Lattanzio, Fabrizia, additional, Lawrence, Catherine B., additional, Lee, Tih-Shih, additional, Lee, Yuan-Kai, additional, Leslie, Paula, additional, Leung, Ping Chung, additional, Li, Runping, additional, Liang, Willmann, additional, Lim, Siong-Meng, additional, Lin, Fengwu, additional, Lin, I-Tsung, additional, Loef, Martin, additional, Lovblad, Karl-Olof, additional, Luque, Evelio, additional, Luz, Protásio Lemos da, additional, Macaulay, S.Lance, additional, Madan, Swati, additional, Maetzler, Walter, additional, Mahendran, R., additional, Majeed, Abu Bakar Abdul, additional, Mander, Alastair G., additional, Mani, Vasudevan, additional, Manley, Graham, additional, Manor, Danny, additional, Margetts, Christine, additional, Marini, Elisabetta, additional, Martin-Fernandez, J.Javier, additional, Martínez-Martos, José Manuel, additional, Martínez, Irene Villegas, additional, de Mateo Silleras, Beatriz, additional, Matsuda, Satoru, additional, May, Brian H., additional, McGirr, Alexander, additional, McCormick, Laurie M., additional, Mehta, Jatin, additional, Mereu, Elena, additional, Messina, Antonino, additional, Minami, Akari, additional, Mirowsky, John, additional, Moore, Eileen M., additional, Moreira, Eduardo Luiz Gasnhar, additional, Morelló, José Ramón, additional, Mori, Takashi, additional, Münch, Gerald, additional, Murakami, Kazuma, additional, Mutter, Joachim, additional, Naharci, Mehmet Ilkin, additional, Nakao, Frank Shigeo, additional, Ng, Tze-Pin, additional, Nigro, Julie, additional, Ninomiya, Toshiharu, additional, Nishiyama, Marcelo, additional, Nomani, Erum, additional, Nooyens, Astrid C.J., additional, Oda, Adriana Leico, additional, Okamura, Hitoshi, additional, Oliveira, Acary Souza Bulle, additional, Ono, Yuna, additional, Orsitto, Giuseppe, additional, Ozawa, Mio, additional, Pallet, Véronique, additional, Pamplona, Reinald, additional, Paolisso, Giuseppe, additional, Paradiso, Sergio, additional, Pase, Matthew P., additional, Patki, Gaurav, additional, Piguet, Olivier, additional, Pinto, Alessandro, additional, Pirritano, Domenico, additional, Plastino, Massimiliano, additional, Poggiogalle, Eleonora, additional, Polidori, M.Cristina, additional, Polimanti, Renato, additional, Portero-Otin, Manuel, additional, Power, Brian D., additional, Praticò, Domenico, additional, Prediger, Rui Daniel S., additional, Preedy, Victor R., additional, Prendergast, Mark A., additional, Rae, Daniela, additional, Ramasamy, Kalavathy, additional, Ramli, Muhammad Zaki, additional, Ramirez, Bartolomé, additional, Ramírez-Expósito, María Jesús, additional, Rebec, George V., additional, Reddy, V.Prakash, additional, Redondo del Río, María Paz, additional, Reguant, Jordi, additional, Reisi, Parham, additional, Remington, Ruth, additional, Ricci, Monica, additional, Rizzarelli, Enrico, additional, Robinson, Stephen R., additional, Rogers, Eugene, additional, Rosini, Francesca, additional, Roupas, Peter, additional, Rufa, Alessandra, additional, Russo, María Julieta, additional, Sahathevan, Ramesh, additional, Salim, Samina, additional, Salvioni, Cristina Cleide dos Santos, additional, Sample, Camille H., additional, Santamaría, Abel, additional, Saqqur, Maher, additional, Saragat, Bruno, additional, Sauvant, Julie, additional, Sauvant, Patrick, additional, Scarpini, Elio, additional, Scelza, M.F.Z., additional, Schwen, Richard J., additional, Self, Rachel L., additional, Serrano, José C.E., additional, Shea, Thomas B., additional, Shih, Ping-Hsiao, additional, Shimizu, Takahiko, additional, Shunichiro, Shinagawa, additional, Siahmard, Zahra, additional, Sławek, Jarosław, additional, Smoliner, Christine, additional, Solé, Montse, additional, Sprini, Delia, additional, Squitti, Rosanna, additional, Srulijes, Karin, additional, Stahl, Wilhelm, additional, Stanich, Patricia, additional, Stephens, Brian R., additional, Sun, Mingxue, additional, Takamatsu, Junichi, additional, Tang, Hong Chai, additional, Thandavarayan, Rajarajan A., additional, Torrente, Daniel, additional, Town, Terrence, additional, Túnez, Isaac, additional, Ulatowski, Lynn, additional, Unzeta, Mercedes, additional, Valente, Tony, additional, van Keizerswaard, Jolanda, additional, van de Rest, Ondine, additional, van der Zwaluw, Nikita L., additional, Vecchio, Graziella, additional, Veiga, Judith Jimenez, additional, Vila-Rodriguez, Fidel, additional, Walach, Harald, additional, Warnecke, Tobias, additional, Watters, David A.K., additional, Weber, Wolfgang, additional, Weitzman, Rachel, additional, White, Lon R., additional, Wirth, Rainer, additional, Wu, Chia-Hsien, additional, Xiao, Kai, additional, Xue, Charlie C.L., additional, Yen, Gow-Chin, additional, Yew, David Tai-Wai, additional, Yokoi, Teruo, additional, Zhang, Anthony L., additional, Zhang, Lihong, additional, and Zito, Giancarlo, additional

Published
2015
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25. Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes

Author

Spazzafumo, Liana, Olivieri, Fabiola, Abbatecola, Angela Marie, Castellani, Gastone, Monti, Daniela, Lisa, Rosamaria, Galeazzi, Roberta, Sirolla, Cristina, Testa, Roberto, Ostan, Rita, Scurti, Maria, Caruso, Calogero, Vasto, Sonya, Vescovini, Rosanna, Ogliari, Giulia, Mari, Daniela, Lattanzio, Fabrizia, and Franceschi, Claudio

Published
2013
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36. Pharmacoeconomics and Aging

Author

Bustacchini, Silvia, Corsonello, Andrea, Onder, Graziano, Guffanti, Enrico Eugenio, Marchegiani, Flavio, Abbatecola, Angela Marie, and Lattanzio, Fabrizia

Published
2009
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46. An International Definition for “Nursing Home”

Author

Sanford, Angela M., Orrell, Martin, Tolson, Debbie, Abbatecola, Angela Marie, Arai, Hidenori, Bauer, Juergen M., Cruz-Jentoft, Alfonso J., Dong, Birong, Ga, Hyuk, Goel, Ashish, Hajjar, Ramzi, Holmerova, Iva, Katz, Paul R., Koopmans, Raymond T.C.M., Rolland, Yves, Visvanathan, Renuka, Woo, Jean, Morley, John E., and Vellas, Bruno

Published
2015
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47. Sarcopenia With Limited Mobility : An International Consensus

Author

Morley, John E., Abbatecola, Angela Marie, Argiles, Josep M., Baracos, Vickie, Bauer, Juergen, Bhasin, Shalender, Cederholm, Tommy, Coats, Andrew J. Stewart, Cummings, Steven R., Evans, William J., Fearon, Kenneth, Ferrucci, Luigi, Fielding, Roger A., Guralnik, Jack M., Harris, Tamara B., Inui, Akio, Kalantar-Zadeh, Kamyar, Kirwan, Bridget-Anne, Mantovani, Giovanni, Muscaritoli, Maurizio, Newman, Anne B., Rossi-Fanelli, Filippo, Rosano, Giuseppe M. C., Roubenoff, Ronenn, Schambelan, Morris, Sokol, Gerald H., Storer, Thomas W., Vellas, Bruno, von Haehling, Stephan, Yeh, Shing-Shing, Anker, Stefan D., Morley, John E., Abbatecola, Angela Marie, Argiles, Josep M., Baracos, Vickie, Bauer, Juergen, Bhasin, Shalender, Cederholm, Tommy, Coats, Andrew J. Stewart, Cummings, Steven R., Evans, William J., Fearon, Kenneth, Ferrucci, Luigi, Fielding, Roger A., Guralnik, Jack M., Harris, Tamara B., Inui, Akio, Kalantar-Zadeh, Kamyar, Kirwan, Bridget-Anne, Mantovani, Giovanni, Muscaritoli, Maurizio, Newman, Anne B., Rossi-Fanelli, Filippo, Rosano, Giuseppe M. C., Roubenoff, Ronenn, Schambelan, Morris, Sokol, Gerald H., Storer, Thomas W., Vellas, Bruno, von Haehling, Stephan, Yeh, Shing-Shing, and Anker, Stefan D.

Abstract

A consensus conference convened by the Society of Sarcopenia, Cachexia and Wasting Disorders has concluded that "Sarcopenia, le, reduced muscle mass, with limited mobility" should be considered an important clinical entity and that most older persons should be screened for this condition. "Sarcopenia with limited mobility" is defined as a person with muscle loss whose walking speed is equal to or less than 1 m/s or who walks less than 400 m during a 6-minute walk, and who has a lean appendicular mass corrected for height squared of 2 standard deviations or more below the mean of healthy persons between 20 and 30 years of age of the same ethnic group. The limitation in mobility should not clearly be a result of otherwise defined specific diseases of muscle, peripheral vascular disease with intermittent claudication, central and peripheral nervous system disorders, or cachexia. Clinically significant interventions are defined as an increase in the 6-minute walk of at least 50 meters or an increase of walking speed of at least 0.1 m/s.

Published
2011
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49. Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

Author

Olivieri, Fabiola, primary, Spazzafumo, Liana, additional, Santini, Gabriele, additional, Lazzarini, Raffaella, additional, Albertini, Maria Cristina, additional, Rippo, Maria Rita, additional, Galeazzi, Roberta, additional, Abbatecola, Angela Marie, additional, Marcheselli, Fiorella, additional, Monti, Daniela, additional, Ostan, Rita, additional, Cevenini, Elisa, additional, Antonicelli, Roberto, additional, Franceschi, Claudio, additional, and Procopio, Antonio Domenico, additional

Published
2012
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