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3. Randomized controlled trial on the effect of 1‐hour infusion of vincristine versus push injection on neuropathy in children with cancer (final analysis)

Author

Uittenboogaard, Aniek, primary, van den Berg, Marleen H., additional, Abbink, Floor C. H., additional, Twisk, Jos W. R., additional, van der Sluis, Inge M., additional, van den Bos, Cor, additional, van den Heuvel‐Eibrink, Marry M., additional, Segers, Heidi, additional, Chantrain, Christophe, additional, van der Werff ten Bosch, Jutte, additional, Willems, Leen, additional, Kaspers, Gertjan J. L., additional, and van de Velde, Mirjam Esther, additional

Published
2023
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5. Supplementary Data from Pharmacokinetics of Nilotinib in Pediatric Patients with Philadelphia Chromosome–Positive Chronic Myeloid Leukemia or Acute Lymphoblastic Leukemia

Author

Hijiya, Nobuko, primary, Zwaan, C. Michel, primary, Rizzari, Carmelo, primary, Foà, Robin, primary, Abbink, Floor, primary, Lancaster, Donna, primary, Landman-Parker, Judith, primary, Millot, Frédéric, primary, Moppett, John, primary, Nelken, Brigitte, primary, Caterina Putti, Maria, primary, Tian, Xianbin, primary, Sinclair, Karen, primary, Santanastasio, Helene, primary, Buchbinder, Aby, primary, and Kearns, Pamela, primary

Published
2023
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6. Correction: van de Velde et al. Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial). Cancers 2020, 12, 3745

Author

van de Velde, Mirjam Esther, primary, Kaspers, Gertjan J. L., additional, Abbink, Floor C. H., additional, Twisk, Jos W. R., additional, van der Sluis, Inge M., additional, van den Bos, Cor, additional, van den Heuvel-Eibrink, Marry M., additional, Segers, Heidi, additional, Chantrain, Christophe, additional, van der Werff ten Bosch, Jutte, additional, Willems, Leen, additional, and van den Berg, Marleen H., additional

Published
2023
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7. Randomized controlled trial on the effect of 1-hour infusion of vincristine versus push injection on neuropathy in children with cancer (final analysis)

Author

Uittenboogaard, Aniek, van den Berg, Marleen H., Abbink, Floor C.H., Twisk, Jos W.R., van der Sluis, Inge M., van den Bos, Cor, van den Heuvel-Eibrink, Marry M., Segers, Heidi, Chantrain, Christophe, van der Werff ten Bosch, Jutte, Willems, Leen, Kaspers, Gertjan J.L., van de Velde, Mirjam Esther, Uittenboogaard, Aniek, van den Berg, Marleen H., Abbink, Floor C.H., Twisk, Jos W.R., van der Sluis, Inge M., van den Bos, Cor, van den Heuvel-Eibrink, Marry M., Segers, Heidi, Chantrain, Christophe, van der Werff ten Bosch, Jutte, Willems, Leen, Kaspers, Gertjan J.L., and van de Velde, Mirjam Esther

Abstract

Introduction: Vincristine is an integral component of treatment for children with cancer. Its main dose-limiting side effect is vincristine-induced peripheral neuropathy (VIPN). The VINCA trial was a randomized controlled trial that explored the effect of 1-hour infusion compared with push injection of vincristine on the development of VIPN in children with cancer. The short-term outcomes (median follow-up 9 months) showed that there was no difference in VIPN between the randomization groups. However, 1-hour infusion was less toxic in children who also received azoles. We now report the results of the final analyses (median follow-up 20 months), which includes treatment outcome as a secondary objective (follow-up 3 years). Methods: VIPN was measured 1–7 times per participant using the Common Terminology Criteria for Adverse Events (CTCAE) and the pediatric-modified total neuropathy score. Poisson mixed model and logistic generalized estimating equation analysis for repeated measures were performed.Results: Forty-five participants per randomization group were included. There was no significant effect of 1-hour infusion compared with push injection on VIPN. In participants receiving concurrent azoles, the total CTCAE score was significantly lower in the one-hour group (rate ratio 0.52, 95% confidence interval 0.33–0.80, p = 0.003). Four patients in the one-hour group and one patient in the push group relapsed. Two patients in the one-hour group died. Conclusion:1-hour infusion of vincristine is not protective against VIPN. However, in patients receiving concurrent azoles, 1-hour infusion may be less toxic. The difference in treatment outcome is most likely the result of differences in risk profile.

Published
2023

8. Correction:Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial) (Cancers, (2020), 12, (3745), 10.3390/cancers12123745)

Author

van de Velde, Mirjam Esther, Kaspers, Gertjan J. L., Abbink, Floor C. H., Twisk, Jos W. R., van der Sluis, Inge M., van den Bos, Cor, van den Heuvel-Eibrink, Marry M., Segers, Heidi, Chantrain, Christophe, van der Werff ten Bosch, Jutte, Willems, Leen, van den Berg, Marleen H., Pediatrics, CCA - Cancer Treatment and quality of life, CCA - Cancer biology and immunology, AII - Cancer immunology, Epidemiology and Data Science, APH - Health Behaviors & Chronic Diseases, and APH - Methodology

Abstract

Error in Table In the original publication, there was a mistake in Table 1 as published [1]. The number of patients with death was swapped between the one-hour administration group and the push administration group. The corrected Table 1 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Published
2023

9. Additional file 2 of Support for relatives in the intensive care unit: lessons from a cross-sectional multicentre cohort study during the COVID-19 pandemic

Author

Renckens, Sophie C., Pasman, H. Roeline, Klop, Hanna T., du Perron, Chantal, van Zuylen, Lia, Steegers, Monique A. H., ten Tusscher, Birkitt L., Abbink, Floor C. H., de Ruijter, Wouter, Vloet, Lilian C. M., Koster, Stephanie C. E., and Onwuteaka-Philipsen, Bregje D.

Abstract

Additional file 2. Differences in experiences and satisfaction for different periods between ICU admission and questionnaire completion.

Published
2023
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10. Additional file 1 of Support for relatives in the intensive care unit: lessons from a cross-sectional multicentre cohort study during the COVID-19 pandemic

Author

Renckens, Sophie C., Pasman, H. Roeline, Klop, Hanna T., du Perron, Chantal, van Zuylen, Lia, Steegers, Monique A. H., ten Tusscher, Birkitt L., Abbink, Floor C. H., de Ruijter, Wouter, Vloet, Lilian C. M., Koster, Stephanie C. E., and Onwuteaka-Philipsen, Bregje D.

Abstract

Additional file 1. Questionnaire (translated).

Published
2023
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11. Genetic Polymorphisms Associated with Vincristine Pharmacokinetics and Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology Patients

Author

van de Velde, Mirjam E., primary, Uittenboogaard, Aniek, additional, Yang, Wenjian, additional, Bonten, Erik, additional, Cheng, Cheng, additional, Pei, Deqing, additional, van den Berg, Marleen H., additional, van der Sluis, Inge M., additional, van den Bos, Cor, additional, Abbink, Floor C. H., additional, van den Heuvel-Eibrink, Marry M., additional, Segers, Heidi, additional, Chantrain, Christophe, additional, van der Werff ten Bosch, Jutte, additional, Willems, Leen, additional, Evans, William E., additional, and Kaspers, Gertjan J. L., additional

Published
2022
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12. Insomnia Symptoms and Daytime Fatigue Co-Occurrence in Adolescent and Young Adult Childhood Cancer Patients in Follow-Up after Treatment: Prevalence and Associated Risk Factors

Author

Peersmann, Shosha H. M., primary, Grootenhuis, Martha A., additional, van Straten, Annemieke, additional, Tissing, Wim J. E., additional, Abbink, Floor, additional, de Vries, Andrica C. H., additional, Loonen, Jacqueline, additional, van der Pal, Helena J. H., additional, Kaspers, Gertjan J. L., additional, and van Litsenburg, Raphaële R. L., additional

Published
2022
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13. NFB-13. Rhabdoid Tumor Predisposition Syndrome (RTPS) – Finding Evidence by systematic Analyses

Author

Nemes, Karolina, primary, Bens, Susanne, additional, Johann, Pascal D, additional, Steinbügl, Mona, additional, Gruhle, Miriam, additional, Kachanov, Denis, additional, Teleshova, Margarita, additional, Hauser, Peter, additional, Simon, Thorsten, additional, Tippelt, Stephan, additional, Eberl, Wolfgang, additional, Woessmann, Wilhelm, additional, Kratz, Christian, additional, Abbink, Floor, additional, Hernáiz-Driever, Pablo, additional, Eyrich, Matthias, additional, Sumerauer, David, additional, Milde, Till, additional, Reinhard, Harald, additional, Leipold, Alfred, additional, de Wetering, Marianne v, additional, Gil-da-Costa, Maria João, additional, Ebetsberger-Dachs, Georg, additional, Marques, Carmen Hernandez, additional, Bauer, Nina, additional, Biassoni, Veronica, additional, Meneses, Clarice Franco, additional, Knirsch, Stephanie, additional, Lauten, Melchior, additional, Gerber, Nicolas U, additional, Chada, Martin, additional, Kerl, Kornelius, additional, Lemmer, Andreas, additional, Heidrun, Boztug, additional, Kuhlen, Michaela, additional, Furtwängler, Rhoikos, additional, Kordes, Uwe, additional, Schneppenheim, Reiner, additional, Vokuhl, Christian, additional, Hasselblatt, Martin, additional, Kröncke, Thomas, additional, Bison, Brigitte, additional, Melchior, Patrick, additional, Timmermann, Beate, additional, Gerss, Joachim, additional, Siebert, Reiner, additional, and Frühwald, Michael C, additional

Published
2022
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14. Prevalence of Sleep Disorders, Risk Factors and Sleep Treatment Needs of Adolescents and Young Adult Childhood Cancer Patients in Follow-Up after Treatment

Author

Peersmann, Shosha H.M., Grootenhuis, M.A., Straten, Annemieke van, Kerkhof, Gerard A., Tissing, W.J., Abbink, Floor, Loonen, J.J., Kaspers, Gertjan J.L., Litsenburg, R.R.L. van, Peersmann, Shosha H.M., Grootenhuis, M.A., Straten, Annemieke van, Kerkhof, Gerard A., Tissing, W.J., Abbink, Floor, Loonen, J.J., Kaspers, Gertjan J.L., and Litsenburg, R.R.L. van

Abstract

Contains fulltext : 247984.pdf (Publisher’s version ) (Open Access)

Published
2022

15. Insomnia Symptoms and Daytime Fatigue Co-Occurrence in Adolescent and Young Adult Childhood Cancer Patients in Follow-Up after Treatment: Prevalence and Associated Risk Factors

Author

Peersmann, Shosha H.M., Grootenhuis, M.A., Straten, Annemieke van, Tissing, W.J.E., Abbink, Floor, Vries, A.C. de, Loonen, J.J., Kaspers, Gertjan J.L., Litsenburg, R.R.L. van, Peersmann, Shosha H.M., Grootenhuis, M.A., Straten, Annemieke van, Tissing, W.J.E., Abbink, Floor, Vries, A.C. de, Loonen, J.J., Kaspers, Gertjan J.L., and Litsenburg, R.R.L. van

Abstract

Contains fulltext : 253167.pdf (Publisher’s version ) (Open Access)

Published
2022

16. Insomnia Symptoms and Daytime Fatigue Co-Occurrence in Adolescent and Young Adult Childhood Cancer Patients in Follow-Up after Treatment:Prevalence and Associated Risk Factors

Author

Peersmann, Shosha H.M., Grootenhuis, Martha A., van Straten, Annemieke, Tissing, Wim J.E., Abbink, Floor, de Vries, Andrica C.H., Loonen, Jacqueline, van der Pal, Helena J.H., Kaspers, Gertjan J.L., van Litsenburg, Raphaële R.L., Peersmann, Shosha H.M., Grootenhuis, Martha A., van Straten, Annemieke, Tissing, Wim J.E., Abbink, Floor, de Vries, Andrica C.H., Loonen, Jacqueline, van der Pal, Helena J.H., Kaspers, Gertjan J.L., and van Litsenburg, Raphaële R.L.

Abstract

Insomnia symptoms and daytime fatigue commonly occur in pediatric oncology, which significantly impact physical and psychosocial health. This study evaluated the prevalence of insomnia only, daytime fatigue only, the co-occurrence of insomnia–daytime fatigue symptoms, and associated risk factors. Childhood cancer patients (n = 565, 12–26 years old, ≥6 months after treatment) participated in a national, cross-sectional questionnaire study, measuring insomnia symptoms (ISI; Insomnia Severity Index) and daytime fatigue (single item). Prevalence rates of insomnia and/or daytime fatigue subgroups and ISI severity ranges were calculated. Multinomial regression models were applied to assess risk factors. Most patients reported no insomnia symptoms or daytime fatigue (61.8%). In the 38.2% of patients who had symptoms, 48.1% reported insomnia and daytime fatigue, 34.7% insomnia only, and 17.1% daytime fatigue only. Insomnia scores were higher in patients with insomnia–daytime fatigue compared to insomnia only (p < 0.001). Risk factors that emerged were: female sex and co-morbidities (all), shorter time after treatment and bedtime gaming (insomnia only), young adulthood (insomnia–fatigue/fatigue only), needing someone else to fall asleep and inconsistent wake times (both insomnia groups), lower educational level and consistent bedtimes (insomnia–fatigue). Insomnia symptoms and daytime fatigue are common and often co-occur. While current fatigue guidelines do not include insomnia symptoms, healthcare providers should inquire about insomnia as this potentially provides additional options for treatment and prevention.

Published
2022

17. Prevalence of Sleep Disorders, Risk Factors and Sleep Treatment Needs of Adolescents and Young Adult Childhood Cancer Patients in Follow-Up after Treatment

Author

Peersmann, Shosha H. M., primary, Grootenhuis, Martha A., additional, van Straten, Annemieke, additional, Kerkhof, Gerard A., additional, Tissing, Wim J. E., additional, Abbink, Floor, additional, de Vries, Andrica C. H., additional, Loonen, Jacqueline, additional, Kremer, Leontien C. M., additional, Kaspers, Gertjan J. L., additional, and van Litsenburg, Raphaële R. L., additional

Published
2022
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18. Oseltamivir-resistant pandemic A(H1N1) 2009 influenza viruses detected through enhanced surveillance in the Netherlands, 2009–2010

Author

Meijer, Adam, Jonges, Marcel, Abbink, Floor, Ang, Wim, van Beek, Janko, Beersma, Matthias, Bloembergen, Peter, Boucher, Charles, Claas, Eric, Donker, Gé, van Gageldonk-Lafeber, Rianne, Isken, Leslie, de Jong, Arjan, Kroes, Aloys, Leenders, Sander, van der Lubben, Mariken, Mascini, Ellen, Niesters, Bert, Oosterheert, Jan Jelrik, Osterhaus, Albert, Riesmeijer, Rob, Riezebos-Brilman, Annelies, Schutten, Martin, Sebens, Fré, Stelma, Foekje, Swaan, Corien, Timen, Aura, van ’t Veen, Annemarie, van der Vries, Erhard, te Wierik, Margreet, and Koopmans, Marion

Published
2011
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19. Carboplatin Dosing in Children Using Estimated Glomerular Filtration Rate: Equation Matters

Author

van de Velde, Mirjam E., primary, den Bakker, Emil, additional, Blufpand, Hester N., additional, Kaspers, Gertjan L., additional, Abbink, Floor C. H., additional, Kors, Arjenne W. A., additional, Wilhelm, Abraham J., additional, Honeywell, Richard J., additional, Peters, Godefridus J., additional, Stoffel-Wagner, Birgit, additional, Buffart, Laurien M., additional, and Bökenkamp, Arend, additional

Published
2021
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20. The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer

Author

van de Velde, Mirjam E., primary, van den Berg, Marleen. H., additional, Kaspers, Gertjan J. L., additional, Abbink, Floor C. H., additional, Twisk, Jos W. R., additional, van der Sluis, Inge M., additional, van den Bos, Cor, additional, van den Heuvel‐Eibrink, Marry M., additional, Segers, Heidi, additional, Chantrain, Christophe, additional, van der Werff Ten Bosch, Jutte, additional, Willems, Leen, additional, and van Litsenburg, Raphaële R. L., additional

Published
2021
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23. Family support on intensive care units during the COVID-19 pandemic: a qualitative evaluation study into experiences of relatives

Author

Klop, Hanna T., primary, Nasori, Mana, additional, Klinge, Tjitske W., additional, Hoopman, Rianne, additional, de Vos, Mirjam A., additional, du Perron, Chantal, additional, van Zuylen, Lia, additional, Steegers, Monique, additional, ten Tusscher, Birkitt L., additional, Abbink, Floor C. H., additional, Onwuteaka-Philipsen, Bregje D., additional, and Pasman, H. Roeline W., additional

Published
2021
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24. Clinical and genetic risk factors define two risk groups of extracranial malignant rhabdoid tumours (eMRT/RTK)

Author

Nemes, Karolina, Bens, Susanne, Kachanov, Denis, Teleshova, Margarita, Hauser, Peter, Simon, Thorsten, Tippelt, Stephan, Woessmann, Wilhelm, Beck, Olaf, Flotho, Christian, Grigull, Lorenz, Driever, Pablo H., Schlegel, Paul-Gerhardt, Khurana, Claudia, Hering, Kathrin, Kolb, Reinhard, Leipold, Alfred, Abbink, Floor, Gil-Da-Costa, Maria J., Benesch, Martin, Kerl, Kornelius, Lowis, Stephen, Marques, Carmen H., Graf, Norbert, Nysom, Karsten, Vokuhl, Christian, Melchior, Patrick, Kroencke, Thomas, Schneppenheim, Reinhard, Kordes, Uwe, Gerss, Joachim, Siebert, Reiner, Furtwaengler, Rhoikos, Fruehwald, Michael C., Nemes, Karolina, Bens, Susanne, Kachanov, Denis, Teleshova, Margarita, Hauser, Peter, Simon, Thorsten, Tippelt, Stephan, Woessmann, Wilhelm, Beck, Olaf, Flotho, Christian, Grigull, Lorenz, Driever, Pablo H., Schlegel, Paul-Gerhardt, Khurana, Claudia, Hering, Kathrin, Kolb, Reinhard, Leipold, Alfred, Abbink, Floor, Gil-Da-Costa, Maria J., Benesch, Martin, Kerl, Kornelius, Lowis, Stephen, Marques, Carmen H., Graf, Norbert, Nysom, Karsten, Vokuhl, Christian, Melchior, Patrick, Kroencke, Thomas, Schneppenheim, Reinhard, Kordes, Uwe, Gerss, Joachim, Siebert, Reiner, Furtwaengler, Rhoikos, and Fruehwald, Michael C.

Abstract

Introduction: Extracranial rhabdoid tumours are rare, highly aggressive malignancies primarily affecting young children. The EU-RHAB registry was initiated in 2009 to prospectively collect data of rhabdoid tumour patients treated according to the EU-RHAB therapeutic framework. Methods: We evaluated 100 patients recruited within EU-RHAB (2009-2018). Tumours and matching blood samples were examined for SMARCB1 mutations by sequencing and cytogenetics. Results: A total of 70 patients presented with extracranial, extrarenal tumours (eMRT) and 30 with renal rhabdoid tumours (RTK). Nine patients demonstrated synchronous tumours. Distant metastases at diagnosis (M+) were present in 35% (35/100), localised disease (M0) with (LN+) and without (LN-) loco-regional lymph node involvement in 65% (65/100). SMARCB1 germline mutations (GLM) were detected in 21% (17/81 evaluable) of patients. The 5-year overall survival (OS) and event-free survival (EFS) rates were 45.8 +/- 5.4% and 35.2 +/- 5.1%, respectively. On univariate analyses, age at diagnosis (>= 12 months), M0-stage, absence of synchronous tumours, absence of a GLM, gross total resection (GTR), radiotherapy and achieving a CR were significantly associated with favourable outcomes. In an adjusted multivariate model presence of a GLM, M+ and lack of a GTR were the strongest significant negative predictors of outcome. Conclusions: We suggest to stratify patients with localised disease (M0), GTR+ and without proof of a GLM (5-year OS 72.2 +/- 9.9%) as 'standard risk'. Patients presenting with one of the features M+ and/or GTR - and/ or GLM+ belong to a high risk group (5-year, OS 32.5 +/- 6.2%). These patients need novel therapeutic strategies such as combinations of targeted agents with conventional chemotherapy or novel experimental approaches ideally within international phase I/II trials. (C) 2020 Elsevier Ltd. All rights reserved.

Published
2021

25. A Minimal Parameter Set Facilitating Early Decision-making in the Diagnosis of Hemophagocytic Lymphohistiocytosis

Author

Immuno/reuma onderzoek 1 (Vastert), Infection & Immunity, Immuno/reuma patientenzorg, Child Health, PMC Medisch specialisten, SCT patientenzorg, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, CTI Research, Cancer, Smits, Bas M, van Montfrans, Joris, Merrill, Samuel A, van de Corput, Lisette, van Gijn, Mariëlle, de Vries, Andrica, van den Bos, Cor, Abbink, Floor, van der Molen, Renate G, Dors, Natasja, Lindemans, Caroline, Boelens, Jaap J, Nierkens, Stefan, Immuno/reuma onderzoek 1 (Vastert), Infection & Immunity, Immuno/reuma patientenzorg, Child Health, PMC Medisch specialisten, SCT patientenzorg, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, CTI Research, Cancer, Smits, Bas M, van Montfrans, Joris, Merrill, Samuel A, van de Corput, Lisette, van Gijn, Mariëlle, de Vries, Andrica, van den Bos, Cor, Abbink, Floor, van der Molen, Renate G, Dors, Natasja, Lindemans, Caroline, Boelens, Jaap J, and Nierkens, Stefan

Published
2021

27. Adjuvant therapy of histopathological risk factors of retinoblastoma in Europe: A survey by the European Retinoblastoma Group (EURbG)

Author

Dittner‐Moormann, Sabine, primary, Reschke, Madlen, additional, Abbink, Floor C. H., additional, Aerts, Isabelle, additional, Atalay, Hatice Tuba, additional, Fedorovna Bobrova, Nadezhda, additional, Biewald, Eva, additional, Brecht, Ines B., additional, Caspi, Shani, additional, Cassoux, Nathalie, additional, Castela, Guilherme, additional, Diarra, Yelena, additional, Duncan, Catriona, additional, Ebinger, Martin, additional, Garcia Aldana, David, additional, Hadjistilianou, Doris, additional, Kepák, Tomáš, additional, Klett, Artur, additional, Kiratli, Hayyam, additional, Maka, Erika, additional, Opocher, Enrico, additional, Pawinska‐Wasikowska, Katarzyna, additional, Rascon, Jelena, additional, Russo, Ida, additional, Rutynowska‐Pronicka, Olga, additional, Sábado Álvarez, Constantino, additional, Pacheco, Sonsoles San Roman, additional, Svojgr, Karel, additional, Timmermann, Beate, additional, Vishnevskia‐Dai, Vicktoria, additional, Eggert, Angelika, additional, Ritter‐Sovinz, Petra, additional, Bechrakis, Nikolaos E., additional, Jenkinson, Helen, additional, Moll, Annette, additional, Munier, Francis L., additional, Popovic, Maja Beck, additional, Chantada, Guillermo, additional, Doz, François, additional, and Ketteler, Petra, additional

Published
2021
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28. Clinical and genetic risk factors define two risk groups of extracranial malignant rhabdoid tumours (eMRT/RTK)

Author

Nemes, Karolina, primary, Bens, Susanne, additional, Kachanov, Denis, additional, Teleshova, Margarita, additional, Hauser, Peter, additional, Simon, Thorsten, additional, Tippelt, Stephan, additional, Woessmann, Wilhelm, additional, Beck, Olaf, additional, Flotho, Christian, additional, Grigull, Lorenz, additional, Driever, Pablo H., additional, Schlegel, Paul-Gerhardt, additional, Khurana, Claudia, additional, Hering, Kathrin, additional, Kolb, Reinhard, additional, Leipold, Alfred, additional, Abbink, Floor, additional, Gil-Da-Costa, Maria J., additional, Benesch, Martin, additional, Kerl, Kornelius, additional, Lowis, Stephen, additional, Marques, Carmen H., additional, Graf, Norbert, additional, Nysom, Karsten, additional, Vokuhl, Christian, additional, Melchior, Patrick, additional, Kröncke, Thomas, additional, Schneppenheim, Reinhard, additional, Kordes, Uwe, additional, Gerss, Joachim, additional, Siebert, Reiner, additional, Furtwängler, Rhoikos, additional, and Frühwald, Michael C., additional

Published
2021
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29. Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial)

Author

van de Velde, Mirjam, primary, Kaspers, Gertjan, additional, Abbink, Floor, additional, Twisk, Jos, additional, van der Sluis, Inge, additional, van den Bos, Cor, additional, van den Heuvel-Eibrink, Marry, additional, Segers, Heidi, additional, Chantrain, Christophe, additional, van der Werff ten Bosch, Jutte, additional, Willems, Leen, additional, and van den Berg, Marleen, additional

Published
2020
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30. Adjuvant therapy of histopathological risk factors of retinoblastoma in Europe: a survey by the European Retinoblastoma group (EURbG)

Author

Dittner-Moormann, Sabine, primary, Reschke, Madlen, additional, Abbink, Floor, additional, Aerts, Isabelle, additional, Atalay, Hatice, additional, Bobrova, Nadezhda Fedorovna, additional, Biewald, Eva, additional, Brecht, Ines, additional, Caspi, Shani, additional, Cassoux, Nathalie, additional, Castela, Guilherme, additional, Diarra, Yelena, additional, Duncan, Catriona, additional, Ebinger, Martin, additional, Aldana, David Garcia, additional, Hadjistilianou, Theodora, additional, Kepák, Tomáš, additional, Klett, Artur, additional, Kiratli, Hayyam, additional, Maka, Erika, additional, Opocher, Enrico, additional, Rascon, Jelena, additional, Pawińska-Wąsikowska, Katarzyna, additional, Russo, Ida, additional, Rutynowska-Pronicka, Olga, additional, Sábado, Constantino, additional, Pacheco, Sonsoles San Roman, additional, Svojgr, Karel, additional, Timmermann, Beate, additional, Vishnevskia-Dai, Vicktoria, additional, Eggert, Angelika, additional, Ritter-Sovinz, Petra, additional, Bechrakis, Nicolaos, additional, Jenkinson, Helen, additional, Moll, Annette, additional, Munier, Francis, additional, Beck-Popovic, Maja, additional, Chantada, Guillermo, additional, Doz, Francois, additional, and Ketteler, Petra, additional

Published
2020
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33. Population Pharmacokinetics of Vincristine Related to Infusion Duration and Peripheral Neuropathy in Pediatric Oncology Patients

Author

van de Velde, Mirjam Esther, primary, Panetta, John Carl., additional, Wilhelm, Abraham J., additional, van den Berg, Marleen H., additional, van der Sluis, Inge M., additional, van den Bos, Cor, additional, Abbink, Floor C.H., additional, van den Heuvel-Eibrink, Marry M., additional, Segers, Heidi, additional, Chantrain, Christophe, additional, van der Werff Ten Bosch, Jutte, additional, Willems, Leen, additional, Evans, William E., additional, and Kaspers, Gertjan L., additional

Published
2020
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34. Pharmacokinetics of Nilotinib in Pediatric Patients with Philadelphia Chromosome–Positive Chronic Myeloid Leukemia or Acute Lymphoblastic Leukemia

Author

Hijiya, Nobuko, primary, Zwaan, C. Michel, additional, Rizzari, Carmelo, additional, Foà, Robin, additional, Abbink, Floor, additional, Lancaster, Donna, additional, Landman-Parker, Judith, additional, Millot, Frédéric, additional, Moppett, John, additional, Nelken, Brigitte, additional, Caterina Putti, Maria, additional, Tian, Xianbin, additional, Sinclair, Karen, additional, Santanastasio, Helene, additional, Buchbinder, Aby, additional, and Kearns, Pamela, additional

Published
2020
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36. Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology Patients Receiving Vincristine through Push Injections or One-Hour Infusions: Results of a Randomized Clinical Trial

Author

Van De Velde, Mirjam Esther, primary, Kaspers, Gertjan Johannes Laurentius, additional, Abbink, Floor, additional, van den Heuvel-Eibrink, Marry M., additional, van den Bos, Cor, additional, van der Sluis, Inge M., additional, Segers, Heidi, additional, Willems, Leen, additional, Van Der Werff, Jutte, additional, Chantrain, Christophe, additional, and van den Berg, Machteld Heleen, additional

Published
2019
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38. Vincristine Induced Peripheral Neuropathy: A Randomized Controlled Trial Comparing Bolus Injections with One Hour Infusions during Induction in a Pediatric Population of Acute Lymphoblastic Leukemia and Hodgkin's Lymphoma

Author

Velde, Mirjam Esther, primary, van den Berg, Machteld Heleen, additional, Abbink, Floor, additional, Segers, Heidi, additional, De Moerloose, Barbara, additional, van den Heuvel-Eibrink, Marry M., additional, van den Bos, Cor, additional, van der Sluis, Inge M., additional, and Kaspers, Gertjan Johannes Laurentius, additional

Published
2018
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39. CONGENITAL RHABDOID TUMORS AS A MAJOR CLINICAL CHALLENGE - A COLLABORATIVE EUROPEAN EFFORT

Author

Nemes, Karolina, Clement, Nathalie, Kachanov, Denis, Bens, Susanne, Shamanskaya, Tatyana, Varfolomeeva, Svetlana, Kerl, Kornelius, Abbink, Floor, Ebinger, Martin, Tippelt, Stephan, Graf, Norbert, Hasselblatt, Martin, Hernaiz-Driever, Pablo, Gil-Da-Costa, Maria Joao, Klingebiel, Thomas, Kortmann, Rolf-Dieter, Pears, Jane, Schlegel, Paul-Gerhardt, Andre, Nicolas, Bertozzi, Anne-Isabelle, Corradini, Nadege, Dufour, Christelle, Fouyssac, Fanny, Leblond, Pierre, Delattre, Olivier, Masliah-Planchon, Julien, Simon, Thorsten, Timmermann, Beate, Witt, Olaf, Schneppenheim, Reinhard, Gerss, Joachim, Siebert, Reiner, Furtwaengler, Rhoikos, Bourdeaut, Franck, Fruehwald, Michael, Fruehwald, Christoph, Nemes, Karolina, Clement, Nathalie, Kachanov, Denis, Bens, Susanne, Shamanskaya, Tatyana, Varfolomeeva, Svetlana, Kerl, Kornelius, Abbink, Floor, Ebinger, Martin, Tippelt, Stephan, Graf, Norbert, Hasselblatt, Martin, Hernaiz-Driever, Pablo, Gil-Da-Costa, Maria Joao, Klingebiel, Thomas, Kortmann, Rolf-Dieter, Pears, Jane, Schlegel, Paul-Gerhardt, Andre, Nicolas, Bertozzi, Anne-Isabelle, Corradini, Nadege, Dufour, Christelle, Fouyssac, Fanny, Leblond, Pierre, Delattre, Olivier, Masliah-Planchon, Julien, Simon, Thorsten, Timmermann, Beate, Witt, Olaf, Schneppenheim, Reinhard, Gerss, Joachim, Siebert, Reiner, Furtwaengler, Rhoikos, Bourdeaut, Franck, Fruehwald, Michael, and Fruehwald, Christoph

Published
2018

40. CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer

Author

Skiles, Jodi L., primary, Chiang, ChienWei, additional, Li, Claire H., additional, Martin, Steve, additional, Smith, Ellen L., additional, Olbara, Gilbert, additional, Jones, David R., additional, Vik, Terry A., additional, Mostert, Saskia, additional, Abbink, Floor, additional, Kaspers, Gertjan J., additional, Li, Lang, additional, Njuguna, Festus, additional, Sajdyk, Tammy J., additional, and Renbarger, Jamie L., additional

Published
2017
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41. TropicALL study : Thromboprophylaxis in Children treated for Acute Lymphoblastic Leukemia with Low molecular-weight heparin: A multicenter randomized controlled trial

Author

Klaassen, Irene L.M., Lauw, Mandy N., van de Wetering, Marianne D, Biemond, Bart J., Middeldorp, Saskia, Abbink, Floor C.H., Bierings, Marc, te Loo, D. Maroeska M.W., Pieters, Rob, van der Sluis, Inge M., Tissing, Wim J.E., Zwaan, C. Michel, van Ommen, C. Heleen, Klaassen, Irene L.M., Lauw, Mandy N., van de Wetering, Marianne D, Biemond, Bart J., Middeldorp, Saskia, Abbink, Floor C.H., Bierings, Marc, te Loo, D. Maroeska M.W., Pieters, Rob, van der Sluis, Inge M., Tissing, Wim J.E., Zwaan, C. Michel, and van Ommen, C. Heleen

Published
2017

42. TropicALL study: Thromboprophylaxis in Children treated for Acute Lymphoblastic Leukemia with Low-molecular-weight heparin: a multicenter randomized controlled trial

Author

Klaassen, Irene L. M., primary, Lauw, Mandy N., additional, van de Wetering, Marianne D., additional, Biemond, Bart J., additional, Middeldorp, Saskia, additional, Abbink, Floor C. H., additional, Bierings, Marc, additional, te Loo, D. Maroeska M. W., additional, Pieters, Rob, additional, van der Sluis, Inge M., additional, Tissing, Wim J. E., additional, Michel Zwaan, C., additional, and Heleen van Ommen, C., additional

Published
2017
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43. Risk-adapted approach for fever and neutropenia in paediatric cancer patients – A national multicentre study

Author

Miedema, Karin G.E., primary, Tissing, Wim J.E., additional, Abbink, Floor C.H., additional, Ball, Lynne M., additional, Michiels, Erna M.C., additional, van Vliet, Michel J., additional, de Vries, Wilma Y., additional, Kamps, Willem A., additional, Norbruis, Obbe F., additional, Fiocco, Marta, additional, de Groot-Kruseman, Hester A., additional, van de Wetering, Marianne D., additional, and de Bont, Eveline S.J.M., additional

Published
2016
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44. Use of Flow Cytometry Immunophenotyping for Diagnosis of Acute Leukemia at Moi Teaching and Referral Hospital, Eldoret, Kenya

Author

Patel, Kirtika, Lotodo, Teresa, Njuguna, Festus, Emonyi, Wilfred, Mining, Simeon, Buziba, Nathan, Czader, Madeline, Chite, Asirwa, Vik, Terry, Kaspers, Gertjan, Westers, Marisa, de Haas, Valerie, Abbink, Floor, Skiles, Jodi, Kigen, Nicholas, Patel, Kirtika, Lotodo, Teresa, Njuguna, Festus, Emonyi, Wilfred, Mining, Simeon, Buziba, Nathan, Czader, Madeline, Chite, Asirwa, Vik, Terry, Kaspers, Gertjan, Westers, Marisa, de Haas, Valerie, Abbink, Floor, Skiles, Jodi, and Kigen, Nicholas

Abstract

The main objective of the study was to compare morphological and flow cytometric diagnosis in patients previously diagnosed with leukemia. The retrospective study was carried out at Moi Teaching and Referral Hospital and patient’s data for the period of July 2013 and June 2014 was used. After Institutional Research Ethics approval was granted. Consecutive sampling was done and information was extracted from patient’s files. Data for all who were previously diagnosed with leukemia through both morphology and immunophenotyping was recorded. The data was collected using a data collection form where socio-demographic data, morphological and flow cytometry results were recorded. The findings were based on 33 patients who underwent both flow cytometry and bone marrow morphology tests for diagnosis of leukemia between July 2013 and June 2014. The ages of the patients ranged from 3 to 76 years. The ratio of male to female was 1:1.1.Using the Bone marrow morphology, 17 patients had AML and 15 had ALL, one case was inconclusive There were five categories for the flow cytometry. They comprised of B-ALL-6 cases, T-ALL-13 cases, AML-10 cases, Biphynotypic-1 case and inconclusive-1case. There was concordance between the morphological and flow cytometry on 25 out of the 33 cases. As a conclusion we can say that at MTRH, Flow cytometry had a role to play to confirm a definite and a probable diagnosis of patients with acute leukemia.

Published
2015

45. Current variations in childhood cancer supportive care in the Netherlands

Author

Loeffen, Erik A. H., primary, Mulder, Renée L., additional, van de Wetering, Marianne D., additional, Font-Gonzalez, Anna, additional, Abbink, Floor C. H., additional, Ball, Lynne M., additional, Loeffen, Jan L. C. M., additional, Michiels, Erna M. C., additional, Segers, Heidi, additional, Kremer, Leontien C. M., additional, and Tissing, Wim J. E., additional

Published
2015
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47. Prevention of central venous catheter-associated bloodstream infections in paediatric oncology patients using 70% ethanol locks: A randomised controlled multi-centre trial

Author

Schoot, Reineke A., primary, van Ommen, C. Heleen, additional, Stijnen, Theo, additional, Tissing, Wim J.E., additional, Michiels, Erna, additional, Abbink, Floor C.H., additional, Raphael, Martine F., additional, Heij, Hugo A., additional, Lieverst, Jan A., additional, Spanjaard, Lodewijk, additional, Zwaan, C. Michel, additional, Caron, Huib N., additional, and van de Wetering, Marianne D., additional

Published
2015
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50. RHABDOID TUMOR PREDISPOSITION SYNDROME (RTPS) - FINDING EVIDENCE BY SYSTEMATIC ANALYSES

Author

Nemes, Karolina, Bens, Susanne, Johann, Pascal D., Steinbuegl, Mona, Gruhle, Miriam, Kachanov, Denis, Teleshova, Margarita, Hauser, Peter, Simon, Thorsten, Tippelt, Stephan, Eberl, Wolfgang, Woessmann, Wilhelm, Kratz, Christian, Abbink, Floor, Hernaiz-Driever, Pablo, Matthias Eyrich, Sumerauer, David, Milde, Till, Reinhard, Harald, Leipold, Alfred, Wetering, Marianne, Gil-Da-Costa, Maria Joao, Ebetsberger-Dachs, Georg, Hernandez Marques, Carmen, Bauer, Nina, Biassoni, Veronica, Meneses, Clarice Franco, Knirsch, Stephanie, Lauten, Melchior, Gerber, Nicolas U., Chada, Martin, Kerl, Kornelius, Lemmer, Andreas, Heidrun, Boztug, Kuhlen, Michaela, Furtwaengler, Rhoikos, Kordes, Uwe, Schneppenheim, Reiner, Vokuhl, Christian, Hasselblatt, Martin, Kroencke, Thomas, Bison, Brigitte, Melchior, Patrick, Timmermann, Beate, Gerss, Joachim, Siebert, Reiner, and Fruehwald, Michael C.

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