15 results on '"Abd El-Rahman HA"'
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2. Effect of different silica sources on cotton leaf worm population in sugar beet plants, and their influence on sugar beet yield
- Author
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Amine HM, Hamed SA, Anbar HA, Shalaby GA, Khazal NM, and Abd El-Rahman HA
- Published
- 2022
3. Comparison of an insecticide and its alternatives on cotton and soybean plants of two-spotted spider mite Tetranychus urticae in laboratory and field
- Author
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Abd El-Rahman HA, Abd El-Salam A Farag, and Hoda T Salim
- Published
- 2022
4. Ameliorative effects of a curcumin vitamin E nanocomposite coated with olive oil against cadmium chloride-induced testicular damage.
- Author
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Abd-Allah ER and Abd El-Rahman HA
- Subjects
- Animals, Cadmium Chloride toxicity, Male, Olive Oil pharmacology, Oxidative Stress, Rats, Sperm Motility, Testis, Vitamin E pharmacology, Vitamin E therapeutic use, Curcumin pharmacology, Curcumin therapeutic use, Nanocomposites
- Abstract
In the current study, we synthesized and prepared a curcumin and vitamin E nanocomposite coated with olive oil (CEONC). Curcumin, vitamin E, and olive oil are fundamental organic antioxidants, and forming nanoparticles from these components endows them with special characteristics. We investigated the protective effect of CEONC on reproductive toxicity induced by cadmium chloride (CdCl
2 ) in male rats. Forty rats (170-180 g) were randomly assigned to four groups: Group 1 (control) received oral distilled water; Group 2 intraperitoneal injection with CEONC (30 mg/kg); Group 3 received oral CdCl2 (5 mg/kg); and Group 4 received CdCl2 (5 mg/kg) followed by CEONC (30 mg/kg) for 4 weeks. After 50 days, we terminated the experiment and assessed male reproductive hormones, sperm motility, viability and morphology, and testes histopathology and conducted a comet assay. The results revealed that co-administration of CEONC with CdCl2 exposure increased reproductive hormone levels, improved sperm motility and viability, prevented sperm morphological changes, recovered the testicular histology, and decreased DNA damage in the testicular tissue compared to rats exposed to CdCl2 alone. CEONC administration produced no adverse effects and enhanced all sperm parameters. Our findings demonstrate that CEONC is a potential treatment for preventing reproductive damage induced by cadmium exposure., (© 2021 Wiley-VCH GmbH.)- Published
- 2022
- Full Text
- View/download PDF
5. Ginger reserves testicular spermatogenesis and steroidogenesis in difenoconazole-intoxicated rats by conducting oxidative stress, apoptosis and proliferation.
- Author
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Khwanes SA, Mohamed RA, Ibrahim KA, and Abd El-Rahman HA
- Subjects
- Animals, Antioxidants metabolism, Antioxidants pharmacology, Apoptosis, Cell Proliferation, Dioxolanes, Male, Oxidative Stress, Rats, Spermatogenesis, Spermatozoa metabolism, Testis metabolism, Testosterone metabolism, Triazoles toxicity, Zingiber officinale
- Abstract
Difenoconazole, a triazole fungicide, can induce reproductive toxicity in aquatic species, but the probable mechanisms of this hazard in mammals are not formally reported. Here, we have examined the possible ameliorative efficiency of the ginger aqueous extract against the reproductive toxicity of difenoconazole in male rats. Thirty-six animals were equally divided into six groups: control, ginger aqueous extract (50 mg/kg), difenoconazole (15 mg/kg), difenoconazole (30 mg/kg) and ginger co-treated with two doses of difenoconazole. Difenoconazole markedly decreased sperm count, motility and normality percentage, together with the Johnson score. Difenoconazole also significantly reduced serum testosterone, luteinizing hormone and follicle-stimulating hormone levels, as well as the activities of testicular steroidogenic acute regulatory protein and 17 β-hydroxysteroid dehydrogenases. Furthermore, difenoconazole brought a significant decrease in the testicular activity of catalase, but it increased the activity of glutathione peroxidase. Moreover, difenoconazole upregulated the testicular transcripts of Bax and caspase-3, increased Ki-67 immunoreactivity and induced histoarchitecture alterations plus DNA damage. Remarkably, ginger co-treatment preserved sperm toxicity, restored hormone profiles, increased steroidogenic activity and prevented oxidative injury-promoted testicular apoptosis. In conclusion, phenolic acids and flavonoids of ginger can reserve spermatogenesis and steroidogenesis in difenoconazole-intoxicated rats by improving testicular redox status, inhibiting apoptosis and refining proliferation capacity., (© 2021 Wiley-VCH GmbH.)
- Published
- 2022
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6. Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR.
- Author
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Helmy MA, Abdalla HA, Abd El Rahman HA, and Ahmed DAM
- Subjects
- Hep G2 Cells, Humans, Phosphatidylinositol 3-Kinases, TOR Serine-Threonine Kinases, Proto-Oncogene Proteins c-akt, Tramadol analogs & derivatives, Tramadol toxicity
- Abstract
1. The aim of this study was to compare the in vitro cytotoxic effect of tramadol and M1 metabolite in HepG2 cell line, the underlying mechanism, and PI3K/AKT/mTOR as potential target.2. Concentrations representing therapeutic level for tramadol (2 µM) and M1 metabolite (0.5 µM) were used. In addition, other increasing concentrations representing higher toxic levels were used (6, 10 µM for tramadol and 1.5, 2.5 µM for M1 metabolites). Cytotoxicity was assessed at 24, 48 and 72 h.3. Both tramadol and M1 metabolites were able to produce cytotoxicity in a dose and time dependent manner. Insignificant difference was detected between cells exposed to tramadol and M1 metabolite at therapeutic concentrations. Tramadol-induced apoptotic and autophagic cell death while M1 metabolite-induced apoptosis only. For PI3K/AKT/mTOR pathway, the therapeutic concentration of tramadol was only able to increase phosphorylation of AKT while higher toxic concentrations were able to increase phosphorylation of whole pathway; Meanwhile, M1 metabolite was able to increase the phosphorylation of the whole pathway significantly in therapeutic and toxic concentrations.4. In conclusion, both tramadol and M1 are equally cytotoxic. Apoptosis and autophagy both mediate hepatic cell death. PI3K/AKT pathway is involved in apoptosis induction while autophagy is regulated through mTOR independent pathway.
- Published
- 2021
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7. Effect of Filgrastim on adult male rats' fertility and reproductive performance.
- Author
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Saber SM, Alduweesh NB, Abd El-Rahman HA, and Omar AR
- Abstract
Filgrastim is a recombinant protein used in treatment neutropenia caused by myelosuppressive medications for patients with non-myeloid cancer. However, its effect in male fertility is not clear. So, the current work aims to clarify the effect of Filgrastim on the reproductive state in Wistar rats. Eighteen (18) male Wistar rats were divided into three groups (6/each). Group (I) where the rats were injected with 0.5 ml/kg/day of distilled water and served as Control Group. The Group (II) animals received intraperitoneal injection of therapeutic dose of 30.83 mcg/kg/day of Filgrastim for one week. The Group (III) rats received the same dose by the same route of Filgrastim for two weeks. Sera of blood samples were processed for serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TS). Semen analysis and resazurine reduction test (RRT) were performed. Assaying for malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) was done. The testes were retrieved for histopathological and immunohistochemical studies for caspase-3 detection. Our results revealed that filgrastim affects sperm morphology, significantly decreased the RRT and the reproductive hormones level, elevated the oxidative stress status and induced several histopathological changes in testes with an increased in immunoexpression of caspase-3 in testes tissues. The results of this work demonstrated that Filgrastim may had a deleterious effect on male fertility., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 The Author(s).)
- Published
- 2021
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8. Quercetin ameliorates the hepatic apoptosis of foetal rats induced by in utero exposure to fenitrothion via the transcriptional regulation of paraoxonase-1 and apoptosis-related genes.
- Author
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Ibrahim KA, Eleyan M, Khwanes SA, Mohamed RA, and Abd El-Rahman HA
- Subjects
- Acetylcholinesterase genetics, Acetylcholinesterase metabolism, Animals, Apoptosis drug effects, Aryldialkylphosphatase metabolism, Caspase 9 genetics, Caspase 9 metabolism, Catalase genetics, Catalase metabolism, Chemical and Drug Induced Liver Injury genetics, Chemical and Drug Induced Liver Injury metabolism, Chemical and Drug Induced Liver Injury pathology, Female, Fenitrothion toxicity, Fetus, Gene Expression Regulation, Glutathione Transferase genetics, Glutathione Transferase metabolism, Hepatocytes drug effects, Hepatocytes metabolism, Hepatocytes pathology, Insecticides antagonists & inhibitors, Insecticides toxicity, Liver drug effects, Liver metabolism, Liver pathology, Male, Nitric Oxide metabolism, Oxidative Stress, Pregnancy, Prenatal Exposure Delayed Effects genetics, Prenatal Exposure Delayed Effects metabolism, Prenatal Exposure Delayed Effects pathology, Protein Carbonylation drug effects, Rats, Superoxide Dismutase genetics, Superoxide Dismutase metabolism, Thiobarbituric Acid Reactive Substances metabolism, Tumor Suppressor Protein p53 genetics, Tumor Suppressor Protein p53 metabolism, bcl-2-Associated X Protein genetics, bcl-2-Associated X Protein metabolism, Antioxidants pharmacology, Aryldialkylphosphatase genetics, Chemical and Drug Induced Liver Injury prevention & control, Fenitrothion antagonists & inhibitors, Prenatal Exposure Delayed Effects prevention & control, Quercetin pharmacology
- Abstract
Background & Purpose: Exposure to organophosphorus during different phases of pregnancy induces many adverse impacts on the developing foetuses due to their immature detoxification system. We have estimated the potential amelioration role of quercetin against hepatic injury-induced apoptosis in rat foetuses following gestational exposure to fenitrothion and probable involvement of paraoxonase-1., Methods: Forty pregnant rats were allocated into four groups; the first one kept as control, the second intubated with quercetin (100 mg/kg), the third orally administrated fenitrothion (4.62 mg/kg) and the last group received quercetin two hours before fenitrothion intoxication., Results: Fenitrothion significantly elevated the foetal hepatic levels of thiobarbituric acid reactive substances, protein carbonyl, and nitric oxide, but it reduced the enzymatic activities of glutathione-S-transferase, superoxide dismutase, catalase, and acetylcholinesterase. Furthermore, fenitrothion provoked many histopathological changes in the foetal liver and markedly up-regulated the mRNA gene expression of p53, caspase-9 along with elevation in the immunoreactivity of Bax and caspase-3, but it down-regulated the expression level of paraoxonase-1. Remarkably, quercetin co-treatment successfully ameliorated the hepatic oxidative injury and apoptosis prompted by fenitrothion., Conclusions: Dietary supplements with quercetin can be used to reduce the risk from organophosphorus exposure probably through paraoxonase-1 up-regulation and enhancement of the cellular antioxidant system.
- Published
- 2021
- Full Text
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9. Influence of doxycycline administration on rat embryonic development during organogenesis.
- Author
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Abd-Allah ER and Abd El-Rahman HA
- Subjects
- Animals, Female, Fetus pathology, Pregnancy, Rats, Rats, Wistar, Doxycycline adverse effects, Doxycycline pharmacology, Embryo, Mammalian embryology, Embryonic Development drug effects, Fetus embryology, Organogenesis drug effects
- Abstract
This experiment was performed to evaluate the possible embryotoxic and teratogenic effects of doxycycline during rat development. Twenty-one female rats were used and distributed into three groups equally (seven animals/group). The low dose group received doxycycline at a dose of 5 mg/kg bw/day orally from the 6th to 14th day of gestation. The high dose group received 10 mg/kg bw/day orally for the same period, the Control group received 1 mL distilled water orally for the same period. The dams were dissected on the 20th day of gestation and their fetuses were subjected to morphological, skeletal, and histological examination. Moreover, DNA damage analysis of liver cells of pregnant rats and their fetuses or fetal skull was assessed by Comet assay. The obtained results showed a significant decrease in fetal body weight, several morphological anomalies, and severe lack of ossification on the skull bones, phalanges, and sternum bone as well as shortness in the ulna and radius bones. Histological studies of pregnant rats revealed congestion and dilatation of the central vein of the liver lobules and fatty degeneration of the hepatocytes. In addition, 20 day-fetuses showed a marked increase of necrotic hepatocytes associated with an increased average of megakaryocytes and periportal leukocytic infiltration. Moreover, doxycycline induced a significant increase in the percentage of DNA damage and tail length of examined samples. Conclusively, doxycycline caused certain fetal abnormalities, so it is advisable to avoid using this drug during pregnancy., (© 2020 Wiley Periodicals LLC.)
- Published
- 2021
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10. Quercetin Attenuates the Oxidative Injury-Mediated Upregulation of Apoptotic Gene Expression and Catecholaminergic Neurotransmitters of the Fetal Rats' Brain Following Prenatal Exposure to Fenitrothion Insecticide.
- Author
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Ibrahim KA, Eleyan M, Abd El-Rahman HA, Khwanes SA, and Mohamed RA
- Subjects
- Animals, Antioxidants pharmacology, Antioxidants therapeutic use, Apoptosis drug effects, Apoptosis physiology, Brain drug effects, Brain embryology, Catecholamines genetics, Female, Fetal Development drug effects, Fetal Development physiology, Gene Expression, Oxidative Stress drug effects, Pregnancy, Prenatal Exposure Delayed Effects chemically induced, Prenatal Exposure Delayed Effects prevention & control, Quercetin pharmacology, Rats, Up-Regulation drug effects, Up-Regulation physiology, Brain metabolism, Catecholamines biosynthesis, Fenitrothion toxicity, Insecticides toxicity, Oxidative Stress physiology, Prenatal Exposure Delayed Effects metabolism, Quercetin therapeutic use
- Abstract
The association between gestational exposure to organophosphate and neurodevelopmental deficits is an area of particular interest, since the developing brain is sensitively susceptible to this neurotoxic pesticide. Instead, the neuroprotective role of quercetin has been suggested, but its exact protective mechanism against the developmental neurotoxicity of organophosphate did not previously notify. In this study, we have evaluated the anti-apoptotic role of quercetin against the developmental neurotoxicity of fenitrothion. Forty timed pregnant rats (from the 5th to the 19th day) were divided into four groups: control, quercetin (100 mg/kg/day), fenitrothion (2.31 mg/kg/day), and quercetin-fenitrothion co-treated groups where all animals received the corresponding doses by gavage. The embryotoxicity and many symptoms of the fetal growth retardation were recorded in the fenitrothion-intoxicated group. As compared with the control, fenitrothion brought significant (p < 0.05) elevation in the fetal brain dopamine, serotonin, and malondialdehyde levels as well as the activities of superoxide dismutase and catalase. However, fenitrothion decreased the glutathione concentration together with the activities of acetylcholinesterase, glutathione-S-transferase, and glutathione reductase. Moreover, fenitrothion induced some of the histopathological alterations in fetal brain and remarkably (p < 0.05) upregulated the mRNA gene expression of Bax and caspase-3 plus their protein immunoreactivity. It is worth mentioning that quercetin co-treatment alleviated (p ˂ 0.05) the fetal growth shortfalls, neurotransmission disturbances, lipid peroxidation, antioxidant disorders, and apoptosis evoked by fenitrothion with frequent repair to the control range. These results revealed that the downregulation of apoptosis-related genes and catecholamines is an acceptable indicator for the neuroprotective efficiency of quercetin especially during gestational exposure to organophosphate.
- Published
- 2020
- Full Text
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11. Liraglutide treatment effects on rat ovarian and uterine tissues.
- Author
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Saber SM and Abd El-Rahman HA
- Subjects
- Animals, Body Weight drug effects, Female, Hypoglycemic Agents administration & dosage, Liraglutide administration & dosage, Organ Size drug effects, Ovary anatomy & histology, Oxidative Stress, Rats, Rats, Wistar, Hypoglycemic Agents pharmacology, Liraglutide pharmacology, Ovary drug effects, Uterus drug effects
- Abstract
Liraglutide is a Glucagon-like peptide-1 (GLP-1) analogue used for the treatment of type II diabetes mellitus and obesity. The present study aimed at investigating the effect of Liraglutide in ovarian and uterine tissues in albino rats. 30 female rats were divided into 3 groups, 10 rats each. Group (I) served as control group, group (II) animals administrated therapeutic doses of liraglutide for 5 weeks and group (III) animals were injected with Liraglutide as the pervious group. Then they were left for 2 weeks after drug termination as a recovery period. The biochemical results showed a decrease in the female reproductive hormones profile, luteinizing hormone (LH), follicle stimulating hormone (FSH), estrogen (ER), progesterone (PR) and an increase in the level of testosterone (T). Liraglutide administration caused a significant decrease in the antioxidant markers, glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) and a significant increase in the activity of malondialdehyde (MDA). The histopathological examination revealed apoptosis of granulosa cells of different types of follicles with an increase in atretic and disorganized follicles. Vacuolar degenerative changes, and Atrophied muscle with sever inflammatory cell infiltrate in endometrium with congested, dilated blood vessels could be detected in uterine tissues. However, most of the deleterious effects of liraglutide decreased after drug discontinuation. In this study, we clarify the harmful effect of the liraglutide on ovarian and uterine tissues, thus potentially causing reproductive health malfunction and reducing the chances of pregnancy., (Copyright © 2019 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
12. Two novel psychrotolerant species, Bacillus psychrotolerans sp. nov. and Bacillus psychrodurans sp. nov., which contain ornithine in their cell walls.
- Author
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Abd El-Rahman HA, Fritze D, Spröer C, and Claus D
- Subjects
- Bacillus genetics, Base Composition, Cell Wall metabolism, Cold Temperature, DNA, Bacterial chemistry, DNA, Bacterial genetics, DNA, Ribosomal genetics, Molecular Sequence Data, Nucleic Acid Hybridization, Phenotype, Phylogeny, RNA, Bacterial genetics, RNA, Ribosomal, 16S genetics, Terminology as Topic, Bacillus classification, Bacillus metabolism, Ornithine metabolism
- Abstract
Eleven psychrotolerant Bacillus strains with ornithine as diamino acid in position 3 of the peptide side chain of the cell wall and a G+C range of 35.7-38.4 mol% were characterized taxonomically. DNA-DNA hybridization studies confirmed previously physiologically established groups. High DNA-binding values (> 70%) were found within groups I A (consisting of the type strain of Bacillus insolitus DSM 5(T) and Bacillus insolitus DSM 2272), I B (consisting of isolates 3H1(T0, 71H1, 84E1, 87H2 and 4H2) and I C (consisting of isolates 68E39T), 61E1, 4E3 and 67E1). Low DNA-binding values (< 60%) were revealed between the three groups. Consequently, strains of groups I B and I C were considered as being representatives of new psychrotolerant species. For group I B strains the name Bacillus psychrotolerans sp. nov. is proposed with the type strain 3H1(T) (= DSM 11706(T) = NCIMB 13838(T)) and for group I C strains the name Bacillus psychrodurans sp. nov. is proposed with the type strain 68E3(T) (= DSM 11713(T) = NCIMB 13837(T)).
- Published
- 2002
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13. The effect of the aqueous extract of Cynomorium coccineum on the epididymal sperm pattern of the rat.
- Author
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Abd el-Rahman HA, el-Badry AA, Mahmoud OM, and Harraz FA
- Subjects
- Animals, Cell Division drug effects, Epididymis cytology, Male, Rats, Rats, Wistar, Seminal Vesicles cytology, Seminal Vesicles drug effects, Epididymis drug effects, Plant Extracts pharmacology, Plants, Medicinal chemistry, Sperm Count drug effects, Sperm Motility drug effects
- Abstract
An aqueous extract of Cynomorium coccineum was administered by stomach tube to ten mature male Wistar rats, at a dose of 47 mg/100 kg body weight/day for 14 consecutive days. Ten rats were kept as controls and received normal saline by oral route at the same dosing interval. Sperm was collected from the epididymes after decapitation. The results revealed that the water extract of the Cynomorium coccineum induced significant increase in the sperm count, improved the percentage of live sperm and their motility and decreased the number of abnormal sperm. Testicular histology showed increased spermatogenesis and seminiferous tubules full of sperm in the treated group compared with the controls.
- Published
- 1999
- Full Text
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14. New pyrrole alkaloids from Solanum sodomaeum.
- Author
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El Sayed KA, Hamann MT, Abd El-Rahman HA, and Zaghloul AM
- Subjects
- Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Carbohydrate Sequence, Libya, Magnetic Resonance Spectroscopy, Mass Spectrometry, Microbial Sensitivity Tests, Molecular Sequence Data, Mycobacterium drug effects, Solanaceous Alkaloids isolation & purification, Solanaceous Alkaloids pharmacology, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Anti-Bacterial Agents chemistry, Plants, Medicinal chemistry, Solanaceous Alkaloids chemistry
- Abstract
Two new pyrrole alkaloids, solsodomine A and B, were isolated from the fresh berries of Solanum sodomaeum L., collected from the Libyan desert. The structures of these compounds were established by 2D-NMR, including 15N NMR spectroscopy and chemical degradation. Solsodomine A (1) shows activity against Mycobacterium intracellulare. This is the first report of pyrrole alkaloids from the genus Solanum.
- Published
- 1998
- Full Text
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15. Role of fluoride on corrodability of dental amalgams.
- Author
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Naguib EA, Abd-el-Rahman HA, and Salih SA
- Subjects
- Corrosion, Dental Alloys chemistry, Electric Conductivity, Hydrogen-Ion Concentration, Oxidation-Reduction, Potentiometry, Saliva, Artificial, Dental Amalgam chemistry, Sodium Fluoride pharmacology
- Abstract
The role of fluoride ions on the corrosion behavior of some commercial dental amalgam in artificial saliva solution at pH level 7.1 was studied by using impedance and potentiodynamic polarization techniques. It was found that, the presence of F- ions in an artificial saliva solution at pH 7.1 increases the corrodability of different types of dental amalgam. Sever pitting corrosion occurred at level of 100 mM F- ions. The formulation of amalgam alloys greatly affect the resistance to pitting corrosion; the resistance of the amalgam to pitting follows the order: Dispersalloy >> Phasealloy > Oralloy > Tytin > Valiant-pH.D. It is recommended to avoid oral treatment involving high F- ions concentration in the presence of amalgam restorations.
- Published
- 1994
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