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Abstract Data on the association between social isolation, loneliness, and risk of incident coronary heart disease (CVD) are conflicting. The objective of this study is to determine the relationship between social isolation and loneliness, and the risk of developing cardiovascular disease (CVD) in middle age and elderly using meta-analysis. The purpose of the bibliometric analysis is to systematically evaluate the existing literature on the relationship between social isolation, loneliness, and the risk of developing cardiovascular disease (CVD) in middle-aged and elderly individuals. A comprehensive search through four electronic databases (MEDLINE, Google Scholar, Scopus, and Web of Science) was conducted for published articles that determined the association between social isolation and/or loneliness and the risk of developing coronary heart disease from June 2015 to May 2023. Two independent reviewers reviewed the titles and abstracts of the records. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline to conduct the systematic review and meta-analysis. Data for the bibliometric analysis was obtained from the Scopus database and analyzed using VOSviewer and Bibliometrix applications. Six studies involving 104,511 patients were included in the final qualitative review and meta-analysis after screening the records. The prevalence of loneliness ranged from 5 to 65.3%, and social isolation ranged from 2 to 56.5%. A total of 5073 cardiovascular events were recorded after follow-up, ranging between 4 and 13 years. Poor social relationships were associated with a 16% increase in the risk of incident CVD (Hazard Ratio of new CVD when comparing high versus low loneliness or social isolation was 1.16 (95% Confidence Interval (CI) 1.10–1.22). The bibliometric analysis shows a rapidly growing field (9.77% annual growth) with common collaboration (6.37 co-authors/document, 26.53% international). The US leads research output, followed by the UK and Australia. Top institutions include University College London, Inserm, and the University of Glasgow. Research focuses on "elderly," "cardiovascular disease," and "psychosocial stress," with recent trends in "mental health," "social determinants," and "COVID-19". Social isolation and loneliness increase the risk of and worsen outcomes in incident cardiovascular diseases. However, the observed effect estimate is small, and this may be attributable to residual confounding from incomplete measurement of potentially confounding or mediating factors. The results of the bibliometric analysis highlight the multidimensional nature of CVD research, covering factors such as social, psychological, and environmental determinants, as well as their interplay with various demographic and health-related variables.

Introduction: The pandemic of COVID-19 caused a great challenge to clinical pharmacy programs. Global and local restrictions imposed by prevention and disease control bodies have made clinical training programs hard to implement on campus and/or in hospitals Aims & Objectives: To evaluate the effectiveness of a distance-assembled clinical training program for pharmacy students in Jordan during the COVID-19 pandemic Place and Duration of Study: This study was carried out from July to September 2020 at the College of Pharmacy, University of Petra, Amman-Jordan Material & Method: A Cross-sectional study survey that surveyed pharmacy students during the summer course quasi-experimental design using a post-test-only approach. Only pharmacy students during the summer of 2020 were enrolled in this study. Final year, 4th and 5th year.21 fourth and fifth pharmacy students completed the study. Students from other years were excluded. Specific patient data collection sheets were distributed to pharmacy students enrolled in an integrated pharmacy course in the summer semester from July to September 2020. After data collection, students were asked to develop a detailed pharmaceutical care plan. All sheets and care plans were collected from students, and a course evaluation questionnaire was utilized to measure the outcome of this distance learning approach. This approach focused on vital elements of therapeutic supervision involving appropriate drug indication, drug efficiency, drug safety, and inpatient compliance. The main variables tested in this study were students’ demographics, including gender and year. The second questionnaire consisted of student’s valuation of the clinical pharmacy supervisor. The third (questionnaire consisted of student's evaluation of the collection sheets and care plans for their patients Results: The results from the post-training questionnaire showed that the majority of students reported an apparent improvement in knowledge and clinical skills. Qualitative responses by participating students showed positive responses associated with this distance learning approach, suggesting the possible benefit of such approach on long-term clinical pharmacy education. Conclusion: A successful outline of a distanced organized clinical training for pharmacy students has been established during COVID19. Both the patients and the students assigned to them benefited from this clinical pharmacy educational experience.

Abstract This study aimed to assess the knowledge regarding impacts, causes and management of black triangles (BT) among participants from different educational backgrounds including dental students, dentists and laypeople. This descriptive cross-sectional observational research included 435 participants who comprised 4 groups: pre-clinical (3rd year) dental students, clinical (4th and 5th year) dental students, dentists, and laypeople. A constructed self-reported questionnaire was utilized to assess participants’ demographic data and their knowledge of the impacts, causes and management of BT. The VAS scale was used to assess participants’ ratings for the impacts of BT on esthetics, with 0 meaning no impact and 10 meaning very severe negative impacts. The most reported treatments for BT were “cannot be treated” 99.3% and “non-surgical periodontal treatment” 67.1%. Meanwhile, the least reported was “modify the porcelain” 41.8%. The most reported cause of BT was “periodontal disease” 85.1%. However, the least reported were “parafunction” and “deep implants” 33.1% each. Dental professionals had better knowledge of the causes (t = 8.189, P

Introduction There is little published information on type 1 diabetes (T1D) in children in Yemen. We aimed to identify the clinical characteristics, biomarkers and diabetic ketoacidosis (DKA) at diagnosis of T1D among children and adolescents in a diabetes centre in Sana’a, Yemen.Methods A total of 485 children and adolescents aged ≤18 years diagnosed with T1D during the period 2010–2020 were included in the study. The variables investigated were demographic and clinical characteristics, biomarkers, subtypes of T1D, and the risk factors for severe DKA at diagnosis.Results At diagnosis, children aged

This study utilizes satellite-based rainfall CHIRPS to evaluate GCMs-CMIP6 models over Sudan from 1985 to 2014. Overall, the GCMs of BCC-CSM2-MR, CAMS-CSM1-0, CESM2, ECEarth3-Veg, GFDL-ESM4, MIROC-ES2L, and NorESM2-MM are well reproduced in the unimodal pattern of June to September (JJAS), and hence employed to calculate Multi-Model Ensemble (MME). Then, we examine the capability of the GCMs and MME in replicating the precipitation patterns on annual and seasonal scales over Sudan using numerous ranking metrics, including Pearson Correlation Coefficient (CC), Standard Deviation (SD), Taylor Skill Score (TSS), Mean Absolute Error (MAE), absolute bias (BIAS), and, normalized mean root square error (RMSD). The results show that the MME has the lowest bias and slightly overestimates rainfall over most parts of our study domain, whilst, others (ACCESS-CM2, BCC-CSM2-MR, CAMS-CSM1-0, CESM2, CNRM-CM6-1, CNRM-CM6-1-HR, CNRM-ESM2-1, FGOALS-f3-L, FGOALS-g3) consistently overestimate rainfall in referring to CHIRPS data, respectively, but FIO-ESM-2-0 underestimates bias value. Moreover, MIROC-ES2L and NorESM2-MM demonstrate better performance than the other models. Finally, we employed a bias correction (BC) technique, namely Delta BC, to adjust the GCMs model products through the annual and monsoon seasons. The applied bias correction technique revealed remarkable improvement in the GCMs against the observations, with an improvement of 0 - 18% over the original. However, MME and MIROC-ES2L show better performance after correction than other models.

Abstract Purpose To investigate the effect of different occlusal reduction design on stress distribution and fracture resistance of different endocrown systems. Material and methods Sixty-four maxillary human premolars with endodontic treatment, prepared for endocrowns were divided into 2 groups (n = 32) according to the occlusal design: Butt joint preparation (B group) and Anatomical preparation (A group). Each group were subdivided into four groups according to ceramic systems: IPS E max CAD (EM group), monolithic zirconia (ZR group), Nacera Hyprid (NH group) and PEKKTON (PE group). After manufacturing of endocrowns and adhesive bonding the specimens were thermomechanically loaded and subsequently they were tested in a universal testing machine for evaluating the fracture resistance. The specimens failure mode was qualitatively assessed. The stress distribution in each group was assessed using three-dimensional finite element analysis (FEA). 1-way ANOVA and the Post Hoc Tukey HSD test were used to evaluate the data (a = .05). Results The fracture resistance values between the groups showed statistically significant variations. The B PE and A PE groups had a higher ratio of fracture resistance values. Regarding failure mode, ceramic endocrowns recorded mainly irreparable failures. FEA showed that anatomical occlusal preparation have reduced the stress concentration under all endocrown systems. Conclusion Endocrowns could be used to restore endodontically treated maxillary premolars. PEKKTON endocrowns with anatomical preparations revealed most appropriate restoration. The tested new endocrown systems enhanced the biomechanical performance of the tooth. Clinical significance The innovative endocrown systems (PEKK, Nacera Hyprid) can be seen as a promising choice for restoration of severely-destructed endodontic treated premolars, with less stress transmit to the residual tooth structure. Although the traditional endocrown technology might increase the longevity of tooth bonding, it shouldn’t be used for clenching cases since the risk of failure is too great overall.

Drought poses a serious threat to Sudan, causing water shortages, crop failures, hunger, and conflict. The relationships between Indo-Pacific teleconnections and drought events in Sudan are examined based on the Standardized Precipitation Index (SPI), anomalies, Empirical Orthogonal Function (EOF), correlation, composite analysis, sequential Mann–Kendall test, and MK-trend test during the period of 1993–2022. The results of the SPI-1 values indicate that the extreme drought in Sudan in 2004 was an exceptional case that affected the entire region, with an SPI-1 value of −2 indicating extremely dry conditions. In addition, Sudan experienced moderate to severe drought conditions for several years (1993, 2002, 2008, 2009 and 2015). The Empirical Orthogonal Function showed that the first EOF mode (42.2%) was the dominant variability mode and had positive loading over most of the country, indicating consistent rainfall variation in the central, eastern, and western regions. Correlation analysis showed a strong significant relationship between June–September rainfall and Indian Ocean sea surface temperature (SST) (r ≤ 0.5). Furthermore, a weak positive influence of the Indian Ocean Dipole (IOD) on JJAS precipitation was observed (r ≤ 0.14). Various time lags in the range of ±12 months were examined, with the highest correlation (0.6) found at 9 month among the time lags of ±12 months. This study contributes to a better understanding of drought dynamics and provides essential information for effective drought management in Sudan. Further research is needed to explore the specific mechanisms driving these interactions and to develop tailored strategies to mitigate the impacts of drought events in the future.

Background Overweight and obesity are excessive fat accumulations linked with many health problems, including heart diseases, type 2 diabetes and cancer. Multiple studies have demonstrated that beliefs about overweight, obesity and self-efficacy play essential roles in the success of interventions for obesity management.Objectives This study aimed to identify the perceptions of university students of overweight and obesity using the health belief model (HBM) and to analyse their association with the body mass index (BMI) categories of the students.Design A cross-sectional questionnaire-based study and a multistage sampling technique were used to ensure the recruitment of students from selected colleges of Jazan University—Saudi Arabia.Setting Six colleges of Jazan University were randomly selected to ensure equal representation of health sciences, sciences and humanities colleges.Participants A total of 579 students completed an online survey between January and April 2023.Primary and secondary outcome measures The primary outcome measures were demographic characteristics and HBM constructs. Secondary outcome measures were behavioural intentions relating to obesity management.Results This study demonstrated that gender and self-reported family history of obesity were significantly correlated with the BMI categories of the students (p

Background: Accumulating evidence indicates that the incidence of cancer is increasing in the United Arab Emirates (UAE). This analysis aimed to determine the current cancer research output in the UAE to guide future national research. Methods: The Scopus database was searched for cancer-related bibliographic data from the UAE. The number of publications, citation analysis, co-authorship of the author, institution, and country, keyword co-occurrence, and reference co-citations were analyzed using the R-studio bibliometrics package and VOSviewer software. Results: A total of 1678 journal articles were retrieved from 1981 to 2022. Cancer research in the UAE (UCR) is increasing at a rate of 14.64% (R-squared = 0.75; F = 46.477; P

Background: Beta-thalassemia major (BTM) is still mostly treated with routine blood transfusions. One of the most prevalent transfusion-transmitted infections (TTI) of clinical significance is the hepatitis C virus (HCV). Objectives: To estimate the prevalence of HCV infection among thalassemic patients in Qena hospitals, and to identify the possible risk factors associated with HCV infection. Patients and methods: a cross-sectional study involving 400 thalassemic patients with an age ranging from 1.5 to 29 years, a mean age of 12.8 ±7.3 years, 176 (44%) were male and 224 (56%) were female, and 75.5% were from rural areas. All are reviewed by a structured questionnaire. Results: The study revealed that the prevalence of HCV infection in the studied thalassemic patients was 9.5%. The most important risk factors were the duration of blood transfusion for more than 15 years, previous surgery, dental procedure, and splenectomy (P

Abstract Purpose To assess and compare the impact of various computers aided design/manufacturing (CAD/CAM) materials on internal and marginal discrepancies, fracture resistance and failure probability of Endocrown restorations with 3D Finite Element analysis. Material and methods Forty devitalized human maxillary first molars were collected. After endodontic treatment, they classified into 4 groups (n = 10) based on the materials used for endocrown fabrication. Group V (Vita-Enamic), Group N (Nacera Hybrid), Group T (Translucent Prettau Zirconia) and Group P (Pekkton ivory). All samples were exposed to artificial aging method simulating one year of clinical service. Silicone replica technique and stereomicroscope (25X) utilized to evaluate the marginal and internal gaps of endocrowns at different areas. Fracture resistance test used for cemented specimens followed by qualitative investigation utilizing Stereomicroscopy. Four models representing four endocrown systems used for restoration of severely-damaged endodontically treated upper first molar were generated for finite element analysis (FEA). Axially and centrally static occlusal compressive load was applied. Modified Von Mises and maximum principal stress values on the remaining tooth structure, cement lines and restorative materials were assessed independently. Resulted data were statistically analyzed at P-value ≤ 0.05. Results In the current study, the highest mean values of internal and marginal discrepancies (μm) among studied groups were reported for Zirconia group (100.300 and 102.650) respectively, while the lowest mean value of internal discrepancy (μm) was observed for Nacera group (69.275) and the lowest mean value of marginal discrepancy (μm) was observed for PEKK group (78.4750). Regarding internal discrepancy, Vita-Enamic and PEKK groups did not exhibit any statistically significant differences (P = 0.293), however zirconia and the other tested groups exhibited statistically significant differences in the mean values of the marginal gap region (p 0.05).On the other hand, PEKK group showed the highest mean value of fracture resistance (1845.20 N) and the lowest value was observed for Vita-Enamic group (946.50 N). Regarding to stress distributions through 3D FEA, and according to modified von Mises (mvM) analysis, the greatest possible stress values were noticed in PEKK model in relation to tooth structure, cement line, and flowable composite as the following: (93.1, 64.5, 58.4 MPa) respectively, while Zirconia revealed lower maximum stress values (11.4, 13.6, 11.6 MPa) respectively. Conclusions Statistically excellent marginal and internal fit was observed for PEKK in relation to other used endocrown materials. Also, PEKK material explained fracture resistance comparable to zirconia value while the lowest value was detected for Vita Enamic material.

BACKGROUND: Postpartum depression (PPD) is a major and common mental health problem complicating maternal status after delivery, mainly associated with maternal suffering and altering the mental status for both herself and her offspring. It is a complex condition results mainly from a mix of physical, emotional, and behavioral changes happens to women after giving birth. The interactions between chemical, social, and psychological variables factors especially in newly mothers experience are probably responsible for initiation and ranges of postpartum depression. METHODS: This study will be conducted via Cohort – analytical study design based on retrospective database in the last 3 years from current day, will be conducted from Taha Baasher hospital medical records, a psychiatry department. The process started from October 2021. We used scientifically structured questionnaire as a tool to collect data from registered patient’s data with approval from Alzaiem Alazhari University. RESULTS: Total of 79 cases have been studied in order to analyze the most prominent data they might have role in developing causes or risk factor of postpartum depression. The percentage of different parameters manly young age 62.5%, education of primary school 41.3%, with high percentage of positive family history of mental illness and previous history mental illness, 42.1% and 32.9% respectively. The majority of the cases have Moderate symptoms 53.8%, while 27.5% were Severe. The risk of patients was classified into homicidal 3.8% and suicidal were 7.7%. The final diagnosis of the cases was psychosis 76.5% and only 23.5% was depression. Treatment by drugs only was about 97.5%. CONCLUSION: Total of 79 cases have been studied in order to analyze the most prominent data they might have role in developing causes or risk factor of postpartum depression. The percentage of different parameters manly young age 62.5%, education of primary school 41.3%, with high percentage of positive family history of mental illness and previous history mental illness, 42.1% and 32.9% respectively. The majority of the cases have Moderate symptoms 53.8%, while 27.5% were Severe. The risk of patients was classified into homicidal 3.8% and suicidal were 7.7%. The final diagnosis of the cases was psychosis 76.5% and only 23.5% was depression. Treatment by drugs only was about 97.5%.