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Background: Chronic kidney disease (CKD) is a major public health issue that is increasingly common in the senior population around the world. However, there are a few research on muscular function in CKD-affected older persons. This study aims to evaluate the function of upper limb muscles in elderly CKD patients. Methods: A case-control study was conducted, including 73 patients with CKD and 73 healthy individuals as a control group. Patients were divided into two groups: 37 predialysis patients and 36 patients on regular hemodialysis. History was recorded, blood pressure, anthropometric measures, handgrip strength (HGS) were assessed, and a blood sample was withdrawn for measuring complete blood count, random blood sugar, lipid profile, renal and liver function tests. Results: In comparison to the control group, CKD patients were having a significantly lower HGS. Predialysis CKD patients have significantly higher HGS compared with patients on regular hemodialysis. Both hemoglobin and albumin were positively correlated with HGS. Fasting triglycerides were inversely correlated with HGS. Conclusions: There is a significant decline in upper limb muscle function in CKD patients. The decline in muscle function is more evident in hemodialysis than in predialysis CKD patients. [ABSTRACT FROM AUTHOR]

Background: Chronic kidney disease (CKD) is a worldwide public health problem and a major cause of suffering and having a reduced quality of life for those affected. Objective: We aimed to study the changes in red blood cell indices and mineral bone metabolism in hemodialysis patients and to explore the correlation between these studied parameters. Patients and Methods: This is a case control study included 55 adult patients with end stage renal disease on maintenance hemodialysis as well as 55 healthy individuals as a control group. All participants were subjected to laboratory investigations included complete blood count and serum levels of creatinine, urea, total calcium, albumin, phosphate and intact parathyroid hormone (iPTH). Results: Our study showed that hemoglobin (Hb), hematocrit and red blood cell count were significantly reduced in the hemodialysis patients (P<0.001 for all). Regarding mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, no significant differences were found between the hemodialysis patients and the control group (P= 0.362, 0.116, 0.22, respectively). In the hemodialysis group, the albumin-corrected serum calcium level was significantly lower while the serum phosphate and iPTH levels were significantly higher compared to the control group (P<0.001 for all). Hb was inversely correlated with serum iPTH (r=-0.359, P=0.007) and serum phosphate (r=-0.570, P<0.001) in the hemodialysis group and was inversely correlated with serum phosphate (r=- 0.495, P<0.001) in the control group. Conclusion: Hemodialysis patients are at high risk of anemia, hypocalcemia, hyperphosphatemia and hyperparathyroidism. In hemodialysis patients, an association was found between anemia and each of hyperphosphatemia and hyperparathyroidism. [ABSTRACT FROM AUTHOR]