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Background: Chronic kidney disease (CKD) is a major public health issue that is increasingly common in the senior population around the world. However, there are a few research on muscular function in CKD-affected older persons. This study aims to evaluate the function of upper limb muscles in elderly CKD patients. Methods: A case-control study was conducted, including 73 patients with CKD and 73 healthy individuals as a control group. Patients were divided into two groups: 37 predialysis patients and 36 patients on regular hemodialysis. History was recorded, blood pressure, anthropometric measures, handgrip strength (HGS) were assessed, and a blood sample was withdrawn for measuring complete blood count, random blood sugar, lipid profile, renal and liver function tests. Results: In comparison to the control group, CKD patients were having a significantly lower HGS. Predialysis CKD patients have significantly higher HGS compared with patients on regular hemodialysis. Both hemoglobin and albumin were positively correlated with HGS. Fasting triglycerides were inversely correlated with HGS. Conclusions: There is a significant decline in upper limb muscle function in CKD patients. The decline in muscle function is more evident in hemodialysis than in predialysis CKD patients. [ABSTRACT FROM AUTHOR]

Background: Chronic kidney disease (CKD) is a major health issue that affects people all over the globe. Hematological problems are connected to varying grades of CKD. Objective: To study the relationship between chronic kidney disease and hematological indices, and to study the effect of hemodialysis on these parameters. Subjects and Methods: At Internal Medicine, Faculty of Medicine, Zagazig University, Sharkia, Egypt. we conducted this cross-sectional study in addition to the Nephrology Unit of El-Sahel teaching hospital from May 2019 to February 2020 on 165 subjects categorized into three groups with each group of 55 subjects. Group I included normal healthy persons. Group II involved chronic kidney disease patients not on hemodialysis (NDD-CKD) while Group III included patients on maintenance hemodialysis (DD-CKD). All participants' histories were gathered, with particular attention paid to demographic data and the co-morbid medical conditions as diabetes mellitus and hypertension. Full clinical examination was done including local and systemic examinations. In addition, a complete blood count, urea, and creatinine levels were measured. Results: There is a significant association between CKD and changes in RBCs indices with a significant effect of hemodialysis on these changes. A decrease in the mean platelet count in diseased groups compared with normal ones was revealed. We also found differences between the 3 groups according to WBCs indices with significant changes between the 3 groups in TLC. Conclusion: CKD impacts all hematological parameters and hemodialysis also influence all these parameters [ABSTRACT FROM AUTHOR]