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6. Pristinamycin‐induced toxic epidermal necrolysis: A case report.

Author

Ouni, Bouraoui, Mansour, Khadija, Slim, Raoudha, Abdessayed, Nihed, Bensayed, Nesrine, Barka, Malek, and Fathallah, Neila

Subjects
TOXIC epidermal necrolysis, ANTICONVULSANTS, ALLOPURINOL, PAIN management, METHYLPREDNISOLONE
Abstract

Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, life‐threatening and rare severe cutaneous adverse reactions induced by drugs in most cases. The drugs most often reported to be implicated in inducing TEN/SJS are allopurinol, antibacterial sulfonamides, antiepileptic drugs and oxicam. Pristinamycin is an oral streptogramin antibiotic with bactericidal activity against Gram‐positive bacteria that is rarely linked to TEN. Typically, this condition develops 4‐28 days after drug exposure, Herein, we report a case of a 71‐year‐old female who developed TEN within 3 days of administration of pristinamycin and was managed successfully with supportive care, including intravenous fluids, pain control, prophylactic antibiotics and intravenous methylprednisolone. This case of rapidly developing SJS/TEN after administration of pristinamycin highlights the possibility that these complications can develop within only a few days following ingestion of drugs thought to be probably safe. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Thrombotic microangiopathy due to acquired complement factor I deficiency in a male receiving interferon‐beta treatment for multiple sclerosis

Author

Mrabet, Sanda, primary, Dahmane, Rihem, additional, Raja, Boukadida, additional, Fradi, Asma, additional, Aicha, Narjess Ben, additional, Sahtout, Wissal, additional, Azzabi, Awatef, additional, Guedri, Yosra, additional, Zellama, Dorsaf, additional, Achour, Abdellatif, additional, Sfar, Imen, additional, Goucha, Rim, additional, Abdessayed, Nihed, additional, and Mokni, Moncef, additional

Published
2022
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16. Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient

Author

Mrabet, Sanda, primary, Romdhane, Wiem, additional, Fradi, Asma, additional, Boukadida, Raja, additional, Azzabi, Awatef, additional, Guedri, Yosra, additional, Sahtout, Wissal, additional, BenAicha, Narjess, additional, Abdessayed, Nihed, additional, Mokni, Moncef, additional, Zellama, Dorsaf, additional, and Achour, Abdellatif, additional

Published
2022
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18. Inflammatory Myopathy with Cardiac Involvement Associated with Anti-Mitochondrial Antibodies

Author

Abdessayed Nihed, Karmani Monia, Rezgui Amel, Ben Fredj Ismail Fatma, Baya Wafa, Anoun Jihed, Laouani Kechrid Chedia, Sriha Badreddine, Mzabi Anis, and Ben Hassine Imen

Subjects
Inflammatory myopathy, biology, business.industry, parasitic diseases, Immunology, biology.protein, Medicine, General Medicine, Antibody, business, medicine.disease
Abstract

Aim: Anti-mitochondrial antibodies (AMA) positive myositis is an atypical and rare form with various characteristics. We aim to highlight these specificities through this case report. Presentation of the Case: We present the case of a young woman diagnosed with frequent polymorphic ventricular extrasystoles and left ventricular dysfunction. Two years after, she developed asthenia and muscle weakness. Clinical and biological tests confirmed the diagnosis of myositis complicated by focal myocarditis. The immunological screening revealed negative antinuclear antibodies and positive AMA type anti-AMA-M2 and anti-M2-3E. A good clinical evolution was noted under corticosteroids and methotrexate. Discussion: Cases of primary biliary cholangitis (PBC) or positive AMA associated with other autoimmune diseases such as systemic scleroderma, Sjögren syndrome, rheumatoid arthritis and myositis have been reported. AMA’s pathogenic role on the musculoskeletal and cardiac systems remains to be clarified. Conclusion: Inflammatory myopathy associated with AMA is a rare and serious entity, characterized by a delayed diagnosis and frequent cardiac involvement, often indicating a heavy treatment.

Published
2021
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19. COVID-19 encephalitis as a differential diagnosis of a Cyclosporine related Posterior Leukoencephalopathy Syndrome (PRES)

Author

mrabet, sanda, primary, Jaziri, Achraf, additional, araoud, maha, additional, Sahtout, Wissal, additional, Zellama, Dorsaf, additional, Achour, Abdellatif, additional, Abdessayed, Nihed, additional, Mokni, Moncef, additional, Naija, Salma, additional, Amor, Sana Ben, additional, Souissi, Alaa, additional, and Jemni, Hela, additional

Published
2022
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24. Dyshormonogenic goiter: about three cases

Author

Ben, Njima Marwa, primary, Malika, El Omri, additional, haouas, jihen, additional, Abir, Meherzi, additional, Monia, Ghammmam, additional, Bellakhdhar, Mouna, additional, abdessayed, nihed, additional, Wassim, Kermani, additional, and Mohamed, Abdelkefi, additional

Published
2022
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25. Distant metastases from thyroid cancers: About 4 cases

Author

Ben, Njima Marwa, primary, Malika, El Omri, additional, Bellakhdhar, Mouna, additional, Haouas, Jihen, additional, Monia, Ghammmam, additional, Abir, Meherzi, additional, Abdessayed, Nihed, additional, Wassim, Kermani, additional, and Mohamed, Abdelkefi, additional

Published
2022
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27. Thrombotic microangiopathy due to acquired complement factor I deficiency in a male receiving interferon‐beta treatment for multiple sclerosis.

Author

Mrabet, Sanda, Dahmane, Rihem, Raja, Boukadida, Fradi, Asma, Aicha, Narjess Ben, Sahtout, Wissal, Azzabi, Awatef, Guedri, Yosra, Zellama, Dorsaf, Achour, Abdellatif, Sfar, Imen, Goucha, Rim, Abdessayed, Nihed, and Mokni, Moncef

Subjects
ECULIZUMAB, INTERFERON beta 1b, MULTIPLE sclerosis, HEMOLYTIC anemia, HEMOLYTIC-uremic syndrome, COMPLEMENT activation, KIDNEY failure
Abstract

Aims: Interferon‐beta (IFNβ), the most widely prescribed medication for multiple sclerosis, is generally considered safe. Nevertheless, rare serious and/or life‐threatening side effects have been reported such as thrombotic microangiopathy. A few mechanisms have been proposed to explain how interferon causes thrombotic microangiopathy, but immunological studies have been unable to pin this phenomenon down to a single pathophysiologic pathway. The aim of this article was to report a new mechanism explaining Interferon beta related thrombotic microangiopathy. Methods: We report thrombotic microangiopathy in a 28‐year‐old male receiving interferon‐beta treatment for multiple sclerosis. Results: After three years of starting interferon beta therapy, the patient presented with malignant hypertension causing seizures, rapidly progressive renal failure requiring haemodialysis and haemolytic anaemia. Corticosteroid and plasma exchange sessions permitted haemolysis control. Nonetheless, the patient remained hemodialysis‐dependent. Exploration of the complement system found a complement factor I deficiency whose activity normalized at the control carried out after 2 years. Conclusion: IFNβ treatment may cause complement factor I deficit, which can lead to thrombotic microangiopathy and severe renal failure. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Paneth cell adenocarcinoma of the colon: A rare entity

Author

Baccouche Atika, Abdessayed Nihed, Mrabet Soumaya, Ben Abdelkader Atef, Hmila Fehmi, Mokni Moncef, and Ben Jazia Ilhem

Subjects
Pathology, medicine.medical_specialty, Adenocarcinoma, Article, 03 medical and health sciences, 0302 clinical medicine, Colonic, Tubular adenoma, Submucosa, Biopsy, medicine, Carcinoma, Pathogenic, Paneth, medicine.diagnostic_test, business.industry, medicine.disease, digestive system diseases, Appendix, medicine.anatomical_structure, Dysplasia, Beta-catenin, 030220 oncology & carcinogenesis, Paneth cell, 030211 gastroenterology & hepatology, Surgery, Cell, business
Abstract

Highlights • Colonic Paneth adenocarcinoma is a rare entity with only a few reports in the world literature. • The pathologist must be aware of the existence of this histological subtype. • A specific pathogen pathway is incriminated. • The treatment remains equal to other classic types of colorectal adenocarcinoma., Introduction Amongst the morphotypes of colorectal adenocarcinomas, the rich cell type of Paneth constitutes a rare histopathologic variant of adenocarcinoma, which can be observed all along the digestive tract but also in other organs such as the prostate or the breast. About 24 cases were found in the literature, with only 7 cases within the colon and appendix. Presentation of case We report the case of a 50-year-old man, without past medical history, complaining of abdominal pain and constipation for 3 months. Biological tests were normal. Radiological investigations and endoscopy revealed a sessile polyp in the right colonic angle measuring 4 cm in greatest diameter. Biopsy concluded to a tubular adenoma with low-grade dysplasia. The patient underwent right hemicolectomy. Microscopically, an invasive adenocarcinoma was identified occupying the colonic mucosal with an invasion of the submucosa. The tumor showed a tubulovillous pattern on the surface and was made mostly of jagged crowded glands in the depth. Some areas exhibit Paneth cell differentiation. No metastatic lymph node was found, and the tumor was staged T1N0. The postoperative course was uneventful. The patient remained free of symptoms at the 6-month follow-up and had no evidence of recurrence. Conclusion We reported a Tunisian case of Paneth cell colonic adenocarcinoma. The diagnosis is challenging in biopsies when only well-differentiated areas are sampled. Lysozyme immune-histochemical stain may be helpful when diagnosis difficulty arises. The beta-catenin pathway seems to be activated. More studies are needed for the etiology, pathogenesis, clinical course, prognosis and treatment of Paneth cell carcinoma.

Published
2019
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35. Immunohistochemical Characterization Improves the Reproducibility of the Histological Diagnosis of Ovarian Carcinoma

Author

Missaoui, Nabiha, Salhi, Said, Bdioui, Ahlem, Mestiri, Sarra, Abdessayed, Nihed, Mokni, Moncef, and Yacoubi, Mohamed Tahar

Subjects
Ovarian Neoplasms, diagnosis, Carcinoma, Reproducibility of Results, Prognosis, Adenocarcinoma, Mucinous, Immunohistochemistry, Cystadenocarcinoma, Serous, Endometrial Neoplasms, histology, Biomarkers, Tumor, Humans, ovary, Female, reproducibility, Research Article, Adenocarcinoma, Clear Cell, Follow-Up Studies, Retrospective Studies
Abstract

Background: Ovarian cancer is the leading cause of gynecologic cancer-related death. Histological assessment remains the standard clue for the diagnosis of ovarian carcinoma. Misinterpretation and inconsistent application of histological criteria may lead to significant interobserver variability and poor reproducibility of the diagnosis. In this study, we investigated the discrepancy in histological diagnosis and the significance of a designed panel of immunohistochemical markers for the improvement of the diagnostic reproducibility of ovarian carcinomas. Methods: We performed a retrospective study on 74 ovarian carcinomas. All tumor slides were independently reviewed by two pathologists. The results for seven available immunomarkers as p53, WT-1, p16INK4A, CK7, CK20, and estrogen and progesterone receptors were determined for all cases by immunohistochemistry. Results: The histological diagnosis review performed using standard histology showed a concordance of diagnoses in 86% of cases with Cohen’s kappa of 0.80. Immunohistochemical results increased significantly the diagnosis reproducibility with a concordance of 91% and a Cohen’s kappa of 0.86 (P = 0.001). Conclusion: Although the histological diagnosis remains reliable, the use of a designed panel of immunohistochemical markers improves significantly the interobserver concordance and the classification accuracy of ovarian carcinomas.

Published
2018

36. Cancer du sein triple négatif: particularités anatomocliniques et moléculaires.

Author

Ben Hammouda, Seifeddine, Abdessayed, Nihed, Ben Abdeljelil, Nouha, Hanchi, Hajer, H'mida, Dorra, and Mokni, Moncef

Subjects
*TRIPLE-negative breast cancer, *LYMPHATIC metastasis, *BREAST cancer, *UNIVERSITY hospitals, *LYMPH nodes, *LOBULAR carcinoma
Abstract

Triple-negative breast cancer (TNBC) is a very heterogeneous disease and refers to a subgroup of breast cancer. The purpose of this study was to describe the clinical, pathological and molecular features of TNBC. We conducted a retrospective analysis of 56 cases of TNBC diagnosed in the Department of Pathology at the Farhat Hached University Hospital over a period of three years (2018-2020). The incidence of TNBC was 5.62% and the mean age of the patients was 50.36 years. The most frequent reason for consultation was the discovery of breast nodules (98.21%). The diagnosis of TNBC was confirmed in 24 cases (42.86%) based on the analysis of mastectomy specimens. Invasive carcinoma of no special type (NST) was the most common histological type (47 cases; 82.5%). Mean tumor size was 35.5 mm. SBR grading was only specified in 42 cases (73.68%). Grade III was the most predominant type (78.6%, n = 33). The notion of lymph node metastasis was found in 44 reports and lymph node invasion was reported in 19 patients (43.2%). Immunohistochemical study showed that all patients were hormone receptornegative (RO and RP) with no Her2 overexpression (n = 56; 100). This study results are generally in agreement with literature data. Despite recent molecular classifications, there is no clinically verified diagnostic test allowing for clear therapeutic standardization. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Soft tissue leiomyosarcoma—diagnostics, management, and prognosis: Data of the registry cancer of the center of Tunisia

Author

Mestiri, Sarra, primary, Elghali, Mohamed Amine, additional, Bourigua, Rym, additional, Abdessayed, Nihed, additional, Nasri, Salsabil, additional, Amine, Ben Abdallah, additional, Missaoui, Nabiha, additional, Ben Maitig, Mahmoud, additional, Hmissa, Sihem, additional, Sriha, Badreddine, additional, and Mokni, Moncef, additional

Published
2019
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45. POST TRAUMATIC SQUAMOUS CELL CARCINOMA OF THE NAIL BED.

Author

Brahem, Aicha, Sridi, Chayma, Boughattas, Anouar, Gaddour, Asma, Abdessayed, Nihed, Ghariani, Najet, Kalboussi, Houda, El Maalel, Olfa, Chatti, Souhaiel, and Mrizak, Néjib

Subjects
SQUAMOUS cell carcinoma, WARTS, NAILS (Anatomy), MYCOSES, TOENAILS, DELAYED diagnosis
Abstract

Squamous cell carcinoma of the nail bed is a rare malignant tumor. The highest incidence occurs in the fingernails of the hand, but involvement of the toenails is also possible. Subungual squamous cell carcinoma often resembles to other more common benign lesions, such as fungal infections, onychomycosis, or viral warts, which explains the frequently delayed diagnosis of this tumor. We report the case of a mason with a subungual squamous cell carcinoma of the right hallux that had developed in a chronic post-traumatic lesion, without bone invasion. Treatment consisted of toe amputation. Further attention to chronic non-healing nail bed lesions is needed. [ABSTRACT FROM AUTHOR]

Published
2022
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