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3 results on '"Abdolghader Tane"'

1. Single Nucleotide Polymorphism of the Interferon-γ Gene (IFN-γ +874 T/A) and the Prognosis of Hepatitis B Infection

Author

Mohammad Sadegh Naghizadeh, Mohsen Naseri, Mohammad Fereyduni, Masoud Ziaee, Abdolghader Tane, Hamidreza Safari, Neda Mahavar, Roya Mahdavi, and Gholamreza Anani Sarab

Subjects
chronic hepatitis b, single nucleotide polymorphism, interferon-γ (+874t/a), iran, Pathology, RB1-214
Abstract

Introduction: Chronic Hepatitis B virus infection is a multifactorial disease with a variety of clinical outcomes. Since interferon-gamma (IFN-γ) is a significant immune factor in antiviral defense, this case-control study aimed to investigate the potential relationship between single nucleotide polymorphism of rs2430561 and hepatitis B infection outcome in a population of Birjand city, eastern Iran. Methods: Blood samples were collected from 60 chronically HBV- infected patients and 60 healthy subjects with the history of HBV infection. Genomic DNA was extracted from whole blood by the salting-out method. The first intron of IFN-γ with a length of 264 bp was amplified by Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR) followed by sequencing. Results: Our results exhibited a statistically significant difference between patients and control individuals (p-value

Published
2018

2. IL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection

Author

Neda Mahavar, Abdolghader Tane, Mohammad Sadegh Naghizadeh, Roya Mahdavi, Mohammad Fereidouni, Mohsen Naseri, Hamidreza Safari, Gholamreza Anani Sarab, and Masood Ziaee

Subjects
0301 basic medicine, Microbiology (medical), Hepatitis B virus, business.industry, Single-nucleotide polymorphism, medicine.disease_cause, Microbiology, Virus, law.invention, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Infectious Diseases, law, Polymorphism (computer science), Immunology, Genotype, Medicine, 030211 gastroenterology & hepatology, Restriction fragment length polymorphism, business, Viral load, Polymerase chain reaction
Abstract

Background: Hepatitis B Virus (HBV) is a universal health challenge all around the world. Several factors like viral load, genetic characteristics, age, sex, and immune status contribute to variable clinical outcomes of HBV infection. The sequels of HBV infection vary remarkably among persons ranging from the spontaneous deletion of infection to persistent infection. Objective: The present study aimed to evaluate the association of single nucleotide polymorphisms IL10-1082 with HBV clearance. Methods: Sixty subjects with Chronic Hepatitis B (CHB) infection and 60 subjects who spontaneously recovered HBV were enrolled in the study. The IL-10-1082 polymorphisms were determined by Polymerase Chain Reaction with Restriction Fragment Length Polymorphism (PCR–RFLP). Results: The clearance of HBV infection demonstrated a significant association with IL-10-1082 polymorphisms in the GG genotype (P = 0.03), while there was no association with other genotypes. Reduced risk of chronic hepatitis B infection was associated with IL-10-1082 GG (OR: 2.33, 95% CI: 1.07 - 5.09). Besides, IL-10-1082 A/G alleles did not differ clearly between the two study groups (P = 0.07) Conclusions: The IL-10-1082 polymorphisms may be associated with a reduced risk of CHB infection and recovery after HBV infection.

Published
2021
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3. Aqueous Cannabis Extract Prevents Induced by Ethylene Glycol-induced Renal Calcium Crystallization

Author

Ahmad Amouzeshi, Seyedeh Zahra Moossavi, Seyed Yoosef Javad Moosavi, Mahmoud Zardast, Mohammad Malekaneh, Sajad Esmaili, Abdolghader Taneh, Nasim Lotfi, maryam moossavi, and Reyhane Hoshyar

Subjects
Antioxidants, Cannabis sativa, Ethylene Glycol, Rats, Urate calcium oxalate stone, Medicine (General), R5-920
Abstract

BACKGROUND: Some plant extracts can prevent kidney stone formation in a dose-dependent manner. In our study, we aimed to investigate the protective role of Cannabis sativa aqueous extraction on calcium oxalate formation in ethylene glycol-induced rats. MATERIALS AND METHODS: To evaluate anti-urolithiasis, variations of the main risk factors (citrate, phosphorous, calcium, and Ph) have been evaluated in 24-hour urine samples of rats one day before the end of the experiment. Rats were divided into 4 groups: group 1 was administered regular drinking water; group 2 was administered 1% ethylene glycol in drinking water, group 3 was administered 100 mg/kg of Cannabis sativa extract for oral administration by gavage along with drinking water containing 1% ethylene glycol; and group 4 was administered 200 mg/kg of Cannabis sativa extract by gavage along with drinking water containing 1% ethylene glycol. Finally, histopathological slides from the kidney were also evaluated. RESULTS: Results showed that 100 mg/kg and 200 mg/kg doses of Cannabis sativa extract significantly reduced the mentioned risk factors in comparison with ethylene glycol-treated rats (p

Published
2019

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