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11 results on '"Abdou, Moustafa"'

3. Evaluation of erythropoietin level in vitreous and serum with detection of erythropoietin gene polymorphism in Egyptian patients with proliferative diabetic retinopathy

Author

Tarek Abdou Moustafa, Radwa S Shahien, Zakia Abu-Zahab, and Mona M Aly

Subjects
medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, Single-nucleotide polymorphism, Vitrectomy, Gastroenterology, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, medicine, Genetic predisposition, business.industry, Retinal detachment, Diabetic retinopathy, medicine.disease, eye diseases, Vascular endothelial growth factor, chemistry, Erythropoietin, 030221 ophthalmology & optometry, sense organs, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Purpose: To measure erythropoietin (EPO) level in vitreous and serum of patients with proliferative diabetic retinopathy (PDR) and to detect EPO single nucleotide polymorphism (SNP) genotyping expression in them. Materials and Methods: Concentrations of EPO in vitreous and serum of twenty diabetic patients with PDR undergoing vitrectomy (PDR group) were measured by chemiluminescent immunoassay and compared with those in nondiabetic (ND) patients undergoing vitrectomy for recent retinal detachment (ND group). Genotyping of EPO gene SNP (rs551238) was performed using real-time polymerase chain reaction technique. Results: There were a significant increase in serum EPO level in PDR group than in ND group and a highly significant increase in vitreous EPO level in PDR group than in ND group. Within the PDR group, vitreous EPO level was significantly higher than its serum level; there was up to 6-fold increase in the EPO vitreous level than its serum level. EPO gene SNP rs551238 was significantly associated with PDR in Egyptian patients. Conclusion: The results of the current study suggest the involvement of EPO in the pathogenesis of PDR. Hence, augmenting vascular endothelial growth factor inhibition with the use of EPO inhibitors may provide a better outcome in PDR treatment. The detection of EPO gene SNP rs551238 in Egyptian patients with PDR may help in the identification of the genetic predisposition to diabetic retinopathy in Egyptians and so may help in prevention and early detection of susceptible candidates to PDR.

Published
2017

5. Hepatopulomnary Syndrome among Cirrhotic Patients in Upper Egypt: Prevalence, Clinical Presentations and Laboratory Features

Author

Hoda A. Makhlouf, Ehab Abdou Moustafa, Mohamed Abdel Ghany, Nahed A. Makhlouf, and Ali Abdel Azeem

Subjects
medicine.medical_specialty, Cirrhosis, integumentary system, business.industry, Pleural effusion, Incidence (epidemiology), respiratory system, medicine.disease, Omics, Gastroenterology, Surgery, Pulmonary function testing, Internal medicine, medicine, Arterial blood, medicine.symptom, business, Hepatopulmonary syndrome, Platypnea
Abstract

Background: The prevalence of Hepatopulmonary Syndrome (HPS) ranges from 5 to 32% from livertransplantation centers. Egypt is considered as one of the highest countries in prevalence and incidence of bilharizial peri-portal fibrosis and Hepatitis C Virus (HCV) induced liver cirrhosis. Clinical, radiological and laboratory features of HPS were not widely assessed. Objectives: To determine the prevalence, clinical features and laboratory features of HPS among Egyptian cirrhotic patients. Patients and Methods: Our study included 570 cirrhotic patients. Arterial blood gases analysis, chest X-ray, pulmonary function tests and transthoracic contrast echocardiography for detection of pulmonary vasodilatation were done for patients with partial pressure of arterial O2

Published
2013

10. Splenic dysfunction from celiac disease resulting in severe babesiosis.

Author

O'Connell S, Lyons C, Abdou M, Patowary R, Aslam S, Kinsella N, Zintl A, Hunfeld KP, Wormser GP, Gray J, Merry C, and Alizadeh H

Subjects
Aged, Humans, Male, Risk Factors, Babesia physiology, Babesiosis parasitology, Celiac Disease complications, Splenic Diseases etiology
Abstract

We describe a 79-year-old Irish man who, because he had hyposplenism and splenic atrophy due to adult celiac disease, became critically ill from a severe Babesia divergens infection. Greater awareness of the possible consequences of splenic dysfunction from adult celiac disease, such as serious pneumococcal infections and babesiosis, is warranted., (Copyright © 2017 Elsevier GmbH. All rights reserved.)

Published
2017
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11. Screening for hepatocellular carcinoma by Egyptian physicians.

Author

Hassany SM, Moustafa EF, Taher ME, Abdeltwab AA, and Blum HE

Abstract

Aim: To assess the practice of Egyptian physicians in screening patients for hepatocellular carcinoma (HCC)., Methods: The study included 154 physicians from all over Egypt caring for patients at risk for HCC. The study was based on a questionnaire with 20 items. Each questionnaire consisted of two parts: (1) personal information regarding the physician (name, age, specialty and type of health care setting); and (2) professional experience in the care of patients at risk for HCC development (screening, knowledge about the cause and natural course of liver diseases and HCC risk)., Results: Sixty-eight percent of doctors with an MD degree, 48% of doctors with a master degree or a diploma and 40% of doctors with a Bachelor of Medicine, Bachelor of Surgery certificate considered the hepatitis C virus (HCV) genotype as risk factor for HCC development (P < 0.05). Ninety percent of physicians specialized in tropical medicine, internal medicine or gastroenterology and 67% of physicians in other specialties advise patients to undergo screening for HCV and hepatitis B virus infection as well as liver cirrhosis (P < 0.05). Eighty-six percent of doctors in University Hospitals and 69% of Ministry of Health (MOH) doctors consider HCV infection as the leading cause of HCC in Egypt (P < 0.05). Seventy-two percent of doctors with an MD degree, 55% of doctors with a master degree or a diploma, 56% of doctors with an MBBCH certificate, 74% of doctors in University Hospitals and 46% of MOH hospital doctors consider abdominal ultrasonography as the most important investigation in HCC screening (P < 0.05). Sixty-five percent of physicians in tropical medicine, internal medicine or gastroenterology and 37% of physicians in other specialties recommend as HCC screening interval of 3 mo (P < 0.05). Seventy-one percent of doctors with an MD degree, 50% of doctors with a master degree or diploma and 60% of doctors with an MBBCH certificate follow the same recommendation., Conclusion: In Egypt, physicians specialized in tropical medicine, internal medicine or gastroenterology with an MD degree and working in a University Hospital are best informed about HCC.

Published
2015
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