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Background and Objectives: Magnetoencephalography (MEG) could be a valuable tool in the presurgical evaluation of drug-resistant epilepsy (DRE), especially when the initial evaluation is inconclusive. In this retrospective study, we describe the profile of MEG in patients with DRE and normal magnetic resonance imaging (MRI). Methods: We included patients with focal epilepsy and normal MRI who underwent presurgical evaluation for DRE. MEG profiles of these patients, including the frequency of spikes, density of clusters, number of clusters, and concordance with video electroencephalography (VEEG), were analyzed. Results: Of the 73 patients included, magnetic source imaging (MSI) provided localizing information in 51 (69.9%) patients. Among patients with localizing MEG findings, localizing information on VEEG too was noted in 42 (57.5% of the whole cohort). Thirty-one (42.5%) patients had concordant findings with region-specific localization, six (8.2%) patients had partial concordance, and five (6.8%) subjects showed discordant findings. There was a moderate agreement for the presumed epileptogenic zone in comparing findings derived from MEG and VEEG (kappa value of 0.451, P < 0.001). The agreement was lower when MEG localized to the frontal lobe (kappa value of 0.379, P = 0.001) than the temporal lobe (kappa value 0.442, P = 0.002). Conclusions: MEG can provide localizing information in most patients with a normal MRI. A moderate degree of agreement between localization by MEG and VEEG was noted. These findings highlight the usefulness of MSI in the presurgical evaluation of MRI-negative DRE. Keywords: Magnetic source imaging, MRI-negative epilepsy, presurgical evaluation of epilepsy, Author(s): Ajay Asranna [1]; Asheeb Abdulhak [1]; Lakshminarayanapuram Gopal Viswanathan [1]; Ravindranandh Chowdary Mundlamuri [1]; Raghavendra Kenchaiah [1]; Mariyappa Narayanan [2]; Bhargava Gautham [2]; Velumurugan Jayabal [2]; Rose Dawn Bharath [...]

This study aims to examine the relationship between reading speed, accurate reading, prosodic reading, and reading comprehension skills, as well as to show the current state of affairs. The study group for the document review-based research consists of publications published between 2011 and 2022 that examine the association between fluent reading and reading skills in Web of Science, Trindex, Google Scholar, and Eric. According to the " Inclusion Criteria" developed by the researchers, fifteen studies were included in the research for analysis after being pre-evaluated. When the studies comprising the study group were examined using the collected codes, it was revealed that there was a strong association between reading accuracy, reading speed, prosodic reading, and reading comprehension. In other words, there is a linear link between these skills that are supposed to be acquired during the read-write process, and these talents are complementary. Therefore, it is recommended to raise awareness and place a greater emphasis on these skills to guarantee that they are acquired optimally during elementary school.

Background and Objectives: Magnetoencephalography (MEG) could be a valuable tool in the presurgical evaluation of drug-resistant epilepsy (DRE), especially when the initial evaluation is inconclusive. In this retrospective study, we describe the profile of MEG in patients with DRE and normal magnetic resonance imaging (MRI). Methods: We included patients with focal epilepsy and normal MRI who underwent presurgical evaluation for DRE. MEG profiles of these patients, including the frequency of spikes, density of clusters, number of clusters, and concordance with video electroencephalography (VEEG), were analyzed. Results: Of the 73 patients included, magnetic source imaging (MSI) provided localizing information in 51 (69.9%) patients. Among patients with localizing MEG findings, localizing information on VEEG too was noted in 42 (57.5% of the whole cohort). Thirty-one (42.5%) patients had concordant findings with region-specific localization, six (8.2%) patients had partial concordance, and five (6.8%) subjects showed discordant findings. There was a moderate agreement for the presumed epileptogenic zone in comparing findings derived from MEG and VEEG (kappa value of 0.451, P < 0.001). The agreement was lower when MEG localized to the frontal lobe (kappa value of 0.379, P = 0.001) than the temporal lobe (kappa value 0.442, P = 0.002). Conclusions: MEG can provide localizing information in most patients with a normal MRI. A moderate degree of agreement between localization by MEG and VEEG was noted. These findings highlight the usefulness of MSI in the presurgical evaluation of MRI-negative DRE.

The purpose of this study is to examine the effect of parent-involved reading activities on elementary fourth graders' reading comprehension skills, reading motivation, and attitudes towards reading. Employing a pretest-posttest quasi-experimental design with a paired control group, data were collected from a total of 100 fourth graders studying in two different primary schools. The findings showed that there were significant differences between the experimental group and the control group, meaning that the parent-involved reading activities developed by the researchers had a positive effect on the students' reading comprehension, reading motivation, and attitudes towards reading. This research contributed to previous body of research regarding the impact of family involvement on academic achievement and affective factors. Various suggestions were offered to policymakers, researchers and practitioners.

Values are the standards that direct our beliefs and behaviors regarding the forms of proper behavior or the purposes of life. The purpose of this research is to examine the views and opinions of university students studying in various departments on values. 411 students studying at various departments of Gümüshane University in the academic year of 2020-2021 constitute the study group. In the research, the Personal Details Form prepared by the researcher and interview questions about values were used as data collection tools. The descriptive analysis method was used in the data analysis. Based on the results of the study, university students understand values as love-respect, customs, family, respect, love, traditions, culture, importance-worth, religious values, national values, moral-ethics, rule, integrity-honesty, unity-cooperation, patriotism, economy, tolerance, cleanliness, friendship, help, self-control, responsibility, law-justice, solidarity, and freedom. Students consider respect, love and integrity, as the most important values for them, respectively. In addition to the foregoing, all university students stated that they attach importance to values, and the vast majority of them stated that they live consistently with values.

Tetracycline is a type of antibiotic that falls under the category of antibiotics. Studying the absorption process of Tetracycline by bio-MOF-11 carrier is important for enhancing drug delivery efficiency, optimizing dosage, and increasing bioavailability, ultimately improving treatment outcomes and potentially leading to the development of new therapies. The present study examined the effect of variable amplitude heat flux (HF) on the bio-MOF-11 carriers' ability to absorb tetracycline. Various parameters were assessed and documented using molecular dynamics simulation and LAMMPS software, including the mean square displacement, number of drug particles, diffusion coefficient, and interaction energy. The results show that by increasing heat flux to 0.04 W/m2, the interaction energy became more negative, decreasing from −1376.35 to −1549.35 kcal/mol. Both mean square displacement and diffusion coefficient increased from 72.906 Å2 and 75.69 28 nm2/ns to 79.745 Å2 and 83.28 nm2/ns, respectively. Also, the number of penetrated Tetracycline-Drug in bio-MOF-11 carriers increased to 606, but it decreased to 520 with a further increase in HF to 0.08 W/m2. The different ways that heat affected adsorption process within the MOF structure may be the cause of this change. The first improvement in penetration can be a sign of improved drug binding and mobility at a moderate HFA. In contrast, the subsequent decrease at higher HFA levels could suggest that excessive heat disrupts the adsorption mechanism, potentially affecting the stability and efficiency of drug delivery within the system.

This study aimed to test the impact of government commitment, curriculum development, and education and training, either directly or indirectly through school management and business actors' participation in maritime learning activities to develop student competencies. This research was conducted in five junior high schools in North Jakarta and Java provinces, Indonesia. The sample size was 175 students of grade IX selected through random sampling techniques. Data was collected through a questionnaire distributed to student respondents, and interviews and focus group discussions with school principals and teachers. Specifically, testing was performed before the questionnaire was administered to determine its validity and reliability using the help of the SPSS program version 24.0. The responses to the questionnaire were processed and analyzed using SEM techniques with the Lisrel 2 version 8.70 program. The findings revealed that variables of government commitment, curriculum development, education and training, directly and indirectly, through school management and business actors' participation, have a positive effect on maritime learning activities. Furthermore, maritime learning activities also have a positive impact on the development of students' competencies, especially in making career choices, developing entrepreneurial aspirations, and developing the love of marine life. On this basis, marine learning activities require attention to influence variables along with indicators that contribute to each of the variables studied. The development of marine competence requires supporting facilities, establishing cooperative relationships with parties outside of school, apprenticeship or training assistance, the availability of learning media (including digital technology as a source of knowledge, information, etc.).

Methicillin-resistant strains of Staphylococcus aureus (MRSA) can harm to public health as they can cause widespread food poisoning and resistance to multiple antibiotics. Therefore, we aimed to investigate the percentage of S. aureus and MRSA among meat and butcher shop tools, utensils, and workers' hands by detecting the presence of the nuc and mecA genes in S. aureus and MRSA isolates, respectively using PCR technique in Mosul city. In this study, we randomly selected 300 samples from meat and various butcher shop surfaces in Mosul city between September 2021 and January 2022. The findings confirmed that S. aureus carried the nuc gene in meat 64% and other samples, ranging from 36% in machines to 82% in knives. Additionally, out of 178 positive S. aureus isolates in this study, 94 samples showed a positive mecA gene for S. aureus. Significant differences were observed among the meat and various utensils of butcher shops. The meat had a higher prevalence of methicillin-resistant S. aureus isolates reach 75% more than the other tools and utensils (machines 38.9%, tables 36.7%, worker hands 38.5%). Further research is necessary to evaluate the existence of enterotoxin genes in Staphylococcus aureus of different meat products.

Abstract Component‐based software development (CBSD) is an emerging technology that integrates existing software components to swiftly develop and deploy big and complex software systems with little engineering effort, money, and time. CBSD, on the other hand, has difficulties with security trust, particularly dependability. When a system provides the desired outcomes while causing no harm to the environment, it is said to be dependable. Dependability encompasses several attributes, including availability, confidentiality, integrity, reliability, safety, and maintainability. Developing dependable component software is achieved by embedding dependability attributes in CBSD. Thus, the CBSD model must address the dependability attributes. Hence, the objectives of this work are: (1) to propose a model for developing a dependable system using component‐based software development approach (hereafter the model is referred to as MDDS‐CBSD), which aims to mitigate software component vulnerabilities, and (2) to assess the proposed model. The best‐practice method was used to frame the CBSD architecture phases and processes, as well as embed the six dependability attributes. The MDDS‐CBSD architecture was evaluated using expert opinion. The MDDS‐CBSD was also used to develop an information and communications technology (ICT) portal using an empirical study method. Vulnerability Assessment Tools were used to assess the developed ICT portal's dependability. The MDDS‐CBSD may be used to create web application systems and to protect them from attacks. Model developers may use CBSD to describe and assess dependability attributes at any point during the model development process. The reliability of this model can also let companies utilise CBSD with confidence.

The article presents the results of the analysis and creation of a classification of power electromagnetic pulse systems based on the theory of a single spatial electromagnetic field developed by the authors. The purpose of the work is to study the phenomena in a single spatial electromagnetic field disinfection of water with a single spatial electromagnetic field, the theory of a single spatial field involves the interaction of four fields: pulsed electromagnetic, pulsed electric, permanent magnetic and gravitational. The theory of a single spatial field is substantiated, which allows us to consider the issues of effective disinfection, desalination and purification of water, as well as to study the influence of electric, magnetic fields and electromagnetic waves on physical, chemical and biological processes occurring in liquids.

The paper presents the results of the analysis of the disinfection of water by a pulsed single spatial electromagnetic field. The origin of the fluid pressure in the pipe is calculated and graphically presented as the interaction of a single spatial field and the current of moving charges. It is proved that a single spatial field enhances the process of dissociation of water in a liquid solution. The orbital electrons of two hydrogen atoms and one oxygen atom of water create a strong inhomogeneous electric field around themselves, which leads to the separation of the liquid solution and the compounds contained in it into elements. The purpose of the work is to study magneto hydrodynamic phenomena spatial electromagnetic field disinfection of water by a single spatial electromagnetic field, The theory of a single spatial field involves the interaction of four fields of pulsed electromagnetic, pulsed electric, permanent magnetic and gravitational. The theory of a single spatial field is substantiated, which allows us to consider the issues of effective disinfection, desalination and purification of water, as well as to study the effects of electric, magnetic fields and electromagnetic waves on physical, chemical and biological processes occurring in liquids.

We examined the potential effects of weed species on the arbuscular mycorrhizal fungi (AMF) in an organic winter wheat (Triticum durum) field in Lebanon. In this agroecosystem, the field and its surroundings were covered with spontaneous vegetation corresponding to local weeds. The coexistence between wheat and weeds did not modify AM fungal community diversity and colonization in T. durum but changed their composition. We evidenced 22 operational taxonomic units (OTUs) specifically shared between wheat associated with weeds (Tdw) and weeds, regardless of their localization and 12 OTUs with an abundance of variation between wheat without neighboring weeds (Td) and Tdw. The number of AM propagules and total C and N contents were higher in soil covered with wheat associated with weeds (TdWsoil) vs. wheat without neighboring weeds (Tdsoil). In greenhouse experiments, the shoot biomass and root mycorrhizal intensity of Medicago sativa, used as a trap plant, were higher using TdWsoil vs. Tdsoil as the inoculum. Positive correlations were observed between soil AM propagule numbers and M. sativa shoot biomass, on the one hand and M. sativa mycorrhizal intensity, on the other hand. Weeds seemed to exert significant effects on root AM fungal composition in T. durum and these effects may contribute to enhanced AMF development in the field.

The purpose of this study is to present an overview of implementation of the national curriculum into the operational curriculum in accordance with the notion of multiple intelligences theory. As data sources, Laboratory Elementary School of Indonesia University of Education, 471 pupils, and 31 teachers participated in the mixed-methods study. Observation, testing, and in-depth indirect communication were used to acquire the data. Observation sheet was used to collect qualitative data on the implementation of the national curriculum into the operational curriculum of the school, Student Self-Multiple Intelligence (SSMI) was used to collect quantitative data on students' Multiple Intelligence scores, and Open-Minded Sharing (OPM) was used to collect quantitative and qualitative data on the impact of the teacher's actions on students. The results demonstrated that the implementation of the national curriculum in the form of an operational curriculum based on multiple intelligences theory showed that the Laboratory Elementary School of Indonesia University of Education is concerned with moral and spiritual values in order to instill noble morals in its pupils, and that it has been successful in assisting its children with the development of various intelligences. We conclude that it has an impact on the characteristics of the school and the learning process which both its own uniqueness.

Identifying the appropriate stakeholder is an integral part of the requirements engineering process and the primary factor influencing system success. The E-learning system is a significant platform with a variety of stakeholders that must be identified. After the launch of the E-learning system, issues such as identifying stakeholders arise and threaten the system's continuity. Moreover, the use of non-scientific and incompatible methods for identifying stakeholders, as well as the limitations of some of these methods, are among other issues that are highlighted in this research. This study investigates the issue of Stakeholder Identification (SI) in the E-learning system and identifies the most influential factors influencing this significant issue. By conducting a comprehensive literature review and employing qualitative data collection and analysis, these factors are addressed. There were 35 survey questionnaires were distributed to experts, analysts, and developers in the field of the E-learning system in Malaysia in 2022 to collect the data. The results reported in this paper demonstrated that there are difficulties in defining the actual stakeholders, as well as a lack of knowledge in employing the appropriate techniques to identify them, which were then analysed and compared to generate the list of factors. The factors identified in this paper help industries understand how critical it is to identify the actual stakeholders of an E-learning system at an early stage. Therefore, industries should be able to develop stable and reliable E-learning systems. This research provides several contributions, including crucial theoretical and practical insights into how E-learning systems are used and adopted. Contributes to the current literature by outlining the key obstacles caused by SI concerns. Identify the most significant components of SI issues, i.e., information quality, time and cost, system utility, and technology. Finally, this paper provides important recommendations for academics, developers, and regulators, allowing them to better understand the critical factors of effective E-learning system implementation.

Education has a very close relationship to the change of values and culture, therefore in order to achieve the purity of the culture, education needs to form a strong individual person, in order to achieve a golden Indonesia by not softening existing values and cultures. Therefore, it is important to conduct this research aiming to find out the socio-cultural system of the Indonesian people in the social science learning curriculum for the junior secondary level in the province of Riau. This study uses descriptive evaluative design with mixed method type that mixed method. Purposive smpling is a sampling technique used by researchers, with several stages of data collection including: observation, interview, documentation and questionnaires. After research and results were obtained that the 2013 curriculum is better used in junior high school students compared to KTSP, by using the 2013 curriculum and a qualified strategy in the learning process can increase students' curiosity towards learning and social problems in the environment, students can understand the learning well and deeper into the value of Malay culture.

Objective: To systematically review the literature and to estimate the risk of chloroquine (CQ) and hydroxychloroquine (HCQ) cardiac toxicity in patients with coronavirus disease 2019 (COVID-19). Methods: We searched multiple data sources including PubMed/MEDLINE, Ovid Embase, Ovid EBM Reviews, Scopus, and Web of Science and medrxiv.org from November 2019 through May 27, 2020. We included studies that enrolled patients with COVID-19 treated with CQ or HCQ, with or without azithromycin, and reported on cardiac toxic effects. We performed a meta-analysis using the arcsine transformation of the different incidences. Results: A total of 19 studies with a total of 5652 patients were included. The pooled incidence of torsades de pointes arrhythmia, ventricular tachycardia, or cardiac arrest was 3 per 1000 (95% CI, 0-21; I2=96%) in 18 studies with 3725 patients. Among 13 studies of 4334 patients, the pooled incidence of discontinuation of CQ or HCQ due to prolonged QTc or arrhythmias was 5% (95% CI, 1-11; I2=98%). The pooled incidence of change in QTc from baseline of 60 milliseconds or more or QTc of 500 milliseconds or more was 9% (95% CI, 3-17; I2=97%). Mean or median age, coronary artery disease, hypertension, diabetes, concomitant QT-prolonging medications, intensive care unit admission, and severity of illness in the study populations explained between-studies heterogeneity. Conclusion: Treatment of patients with COVID-19 with CQ or HCQ is associated with an important risk of drug-induced QT prolongation and relatively higher incidence of torsades de pointes, ventricular tachycardia, or cardiac arrest. Therefore, these agents should not be used routinely in the management of COVID-19 disease. Patients with COVID-19 who are treated with antimalarials for other indications should be adequately monitored.

Abstract The importance of environmental difference among sites and dispersal limitations of species to the explanation of diversity differs among biological systems and geographical regions. We hypothesized that climate and then dispersal limitation will predominantly explain the similarity of alpine vegetation at increasing distances between pairs of regions at subcontinental extent. We computed the similarity of all pairs of 23 European mountain regions below 50° N after dividing the species lists of each region by calcareous or siliceous substrates. Distance decay in similarity was better fitted by a cubic polynomial than a negative exponential function, and the fit was better on calcareous than on siliceous substrate. Commonality analysis revealed that the proportion of explanation of beta diversity by climatic difference had unimodal patterns on a gradient of increasing distance between regions, while explanation by dispersal limitation had consistently rising patterns on both substrates. On siliceous substrate, dispersal limitation explained more of the variation in beta diversity only at longer distances, but it was predominant at all distances on calcareous substrate. The steeper response to distance at 2600 km may indicate dispersal limitation at different temporal scales, and the uptick in the response to distance at the longest distances may reflect how isolated some regions have been before and since the last glacial maximum.