114 results on '"Abdullah, Md P."'
Search Results
2. An Evaluation of Machine Learning Approaches for Early Diagnosis of Autism Spectrum Disorder
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Rasul, Rownak Ara, Saha, Promy, Bala, Diponkor, Karim, S M Rakib Ul, Abdullah, Md. Ibrahim, and Saha, Bishwajit
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Computer Science - Machine Learning - Abstract
Autistic Spectrum Disorder (ASD) is a neurological disease characterized by difficulties with social interaction, communication, and repetitive activities. While its primary origin lies in genetics, early detection is crucial, and leveraging machine learning offers a promising avenue for a faster and more cost-effective diagnosis. This study employs diverse machine learning methods to identify crucial ASD traits, aiming to enhance and automate the diagnostic process. We study eight state-of-the-art classification models to determine their effectiveness in ASD detection. We evaluate the models using accuracy, precision, recall, specificity, F1-score, area under the curve (AUC), kappa, and log loss metrics to find the best classifier for these binary datasets. Among all the classification models, for the children dataset, the SVM and LR models achieve the highest accuracy of 100% and for the adult dataset, the LR model produces the highest accuracy of 97.14%. Our proposed ANN model provides the highest accuracy of 94.24% for the new combined dataset when hyperparameters are precisely tuned for each model. As almost all classification models achieve high accuracy which utilize true labels, we become interested in delving into five popular clustering algorithms to understand model behavior in scenarios without true labels. We calculate Normalized Mutual Information (NMI), Adjusted Rand Index (ARI), and Silhouette Coefficient (SC) metrics to select the best clustering models. Our evaluation finds that spectral clustering outperforms all other benchmarking clustering models in terms of NMI and ARI metrics while demonstrating comparability to the optimal SC achieved by k-means. The implemented code is available at GitHub., Comment: 20 pages, 12 figures, 8 tables
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- 2023
3. SARS-CoV-2 associated septic venous cavernous sinus thrombosis: A case report
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Mark A. Colantonio, MD, Jessica N. Arvon, MD, Nicholas Koenig, BA, Emily Hendricks, MD, and Amirahwaty Abdullah, MD
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COVID-19 ,MRSA ,Hypercoagulable ,Septic cavernous sinus thrombosis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Cavernous sinus thrombosis (CST) is a life-threatening condition occurring due to an active infection, coagulation abnormalities, and trauma. Thromboembolic events are known complications secondary to novel coronavirus disease-19 (COVID-19) due to dysfunction in endothelial function and clotting factor dysfunction. We report a case of cavernous sinus thrombosis and delayed ophthalmic vein thrombosis associated with a preceding COVID-19 infection confirmed with a facial computed tomography (CT) scan. Clinicians should have a broad differential in patients with hypercoagulable states, as complications secondary to COVID-19 can be life-threatening.
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- 2024
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4. Environmental hazard assessment of metals in marine sediments of Sabah and Sarawak, Malaysia
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Ahmed, Amel. Y., Abdullah, Md Pauzi, and Siddeeg, Saifeldin M.
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- 2023
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5. Stress CMR Perfusion Imaging in the Medicare Eligible Population: Insights from the Stress CMR Perfusion Imaging in the United States (SPINS) Study
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Yin Ge, Panagiotis Antiochos, Bobak Heydari, MD, Benedikt Bernhard, MD, Kevin Steel, Scott Bingham, Shuaib M. Abdullah, MD, J Ronald Mikolich, Andrew Arai, Sujata M Shanbhag, W Patricia Bandettini, Amit Patel, MD, Afshin Farzaneh-Far, John F Heitner, Chetan Shenoy, Steve W Leung, Jorge A Gonzalez, Dipan Shah, MD, Subha V Raman, Victor A Ferrari, Jeanette Schulz-Menger, Matthias Stuber, PhD, Orlando Simonetti, PhD, and Raymond Kwong, MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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6. Educating Future Generations of Surgeons across Borders: Novel Global Linked Hybrid Live Cadaveric Peripheral Nerve Surgical Training Course
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Abdus S. Burahee, MBChB, Liron S. Duraku, MD, PhD, Caroline A. Hundepool, MD, PhD, Kyle R. Eberlin, MD, Amy Moore, MD, Christopher J. Dy, MD, Shalimar Abdullah, MD, PhD, Vaikunthan Rajaratnam, MD, PhD, J. Michiel Zuidam, MD, PhD, and Dominic M. Power, MA, MB BChir (Cantab), FRCS (Tr & Orth)
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Surgery ,RD1-811 - Abstract
Background:. This study aimed to evaluate a novel, multi-site, technology-facilitated education and training course in peripheral nerve surgery. The program was developed to address the training gaps in this specialized field by integrating a structured curriculum, high-fidelity cadaveric dissection, and surgical simulation with real-time expert guidance. Methods:. A collaboration between the Global Nerve Foundation and Esser Masterclass facilitated the program, which was conducted across three international sites. The curriculum was developed by a panel of experienced peripheral nerve surgeons and included both text-based and multimedia resources. Participants’ knowledge and skills were assessed using pre- and postcourse questionnaires. Results:. A total of 73 participants from 26 countries enrolled and consented for data usage for research purposes. The professional background was diverse, including hand surgeons, plastic surgeons, orthopedic surgeons, and neurosurgeons. Participants reported significant improvements in knowledge and skills across all covered topics (p < 0.001). The course received a 100% recommendation rate, and 88% confirmed that it met their educational objectives. Conclusions:. This study underscores the potential of technology-enabled, collaborative expert-led training programs in overcoming geographical and logistical barriers, setting a new standard for globally accessible, high-quality surgical training. It highlights the practical and logistical challenges of multi-site training, such as time zone differences and participant fatigue. It also provides practical insights for future medical educational endeavors, particularly those that aim to be comprehensive, international, and technologically facilitated.
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- 2024
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7. Classifying Eye-Tracking Data Using Saliency Maps
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Rahman, Shafin, Rahman, Sejuti, Shahid, Omar, Abdullah, Md. Tahmeed, and Sourov, Jubair Ahmed
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Computer Science - Computer Vision and Pattern Recognition - Abstract
A plethora of research in the literature shows how human eye fixation pattern varies depending on different factors, including genetics, age, social functioning, cognitive functioning, and so on. Analysis of these variations in visual attention has already elicited two potential research avenues: 1) determining the physiological or psychological state of the subject and 2) predicting the tasks associated with the act of viewing from the recorded eye-fixation data. To this end, this paper proposes a visual saliency based novel feature extraction method for automatic and quantitative classification of eye-tracking data, which is applicable to both of the research directions. Instead of directly extracting features from the fixation data, this method employs several well-known computational models of visual attention to predict eye fixation locations as saliency maps. Comparing the saliency amplitudes, similarity and dissimilarity of saliency maps with the corresponding eye fixations maps gives an extra dimension of information which is effectively utilized to generate discriminative features to classify the eye-tracking data. Extensive experimentation using Saliency4ASD, Age Prediction, and Visual Perceptual Task dataset show that our saliency-based feature can achieve superior performance, outperforming the previous state-of-the-art methods by a considerable margin. Moreover, unlike the existing application-specific solutions, our method demonstrates performance improvement across three distinct problems from the real-life domain: Autism Spectrum Disorder screening, toddler age prediction, and human visual perceptual task classification, providing a general paradigm that utilizes the extra-information inherent in saliency maps for a more accurate classification., Comment: Accepted in: International Conference on Pattern Recognition (ICPR)
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- 2020
8. Potential role of tubulin glutamylation in neurodegenerative diseases
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Abdullah Md Sheikh and Shatera Tabassum
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2024
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9. PENGARUH PROSES CRISPING PADA KUALITAS KESEGARAN TESPONG (Oenanthe javanica D. C) SELAMA MASA PENYIMPANAN
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Muhammad Gilang Ramadhan, Sudaryanto Zain, Sarifah Nurjanah, Abdullah Md Zain, Roshita Ibrahim, and Asri Widyasanti
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transpiration ,water celery ,water diffusion ,postharvest ,crisping ,Agriculture - Abstract
Water loss by transpiration causes withering in tespong (water celeries). Crisping can be considered to maintain the availability of water in tespong. The crisping is a process of diffusing water into vegetables through a soaking process by employing the mechanism of opening and closing of stomata and other natural openings which is influenced by surrounding temperature. The purpose of this study was to determine the effect of temperature and soaking time on the crisping process in maintaining the freshness quality of tespong. Tespong samples were immersed at 30°C and 40°C soaking temperatures for 3, 5, 7, and 10 minutes of soaking time, followed by a cooling process in cold storage at 5±2 °C for 16 hours before being stored in a chiller at 8±2°C for 4 days. Tespong’s weight loss, moisture content, color, and texture were observed during the storage time. As a control treatment, 2 groups of tespong were prepared. Control 1 was placed directly in a chiller with a temperature of 5±2°C whereas control 2 was in a laboratory room. The results showed that crisping treatment with 30°C soaking temperatures and 3 minutes soaking time gave better results in maintaining tespong’s freshness where weight loss, moisture content, L, a*, b*, and texture were -5.67%, 89.36%, 52.40, -14.54, 23.84, and 388.44 g/d, respectively.
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- 2023
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10. Analysis of Water Quality of Hatirjheel Lake, Dhaka, Bangladesh
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A. B. M. Kamal Pasha, Syed Omayer Mustafa, S. M. Mahmudur Rahman, Muhammad Abdullah, Md. Azharul Haque Chowdhury and Mahfuza Parveen
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hatirjheel lake, water quality parameters, dissolved oxygen, aquatic ecosystem ,Environmental effects of industries and plants ,TD194-195 ,Science (General) ,Q1-390 - Abstract
The study assessed the status of water quality parameters for an urban water body (Hatirjheel Lake) in Dhaka, the Capital city of Bangladesh. Nine different water samples were collected from nine points of the lake during the dry season in January 2021. Water quality parameters such as pH, electrical conductivity (EC), total dissolved solids (TDS), total suspended solids (TSS), total alkalinity, total acidity, total hardness, Ca2+ hardness, free CO2, and dissolved oxygen (DO) were determined for the samples. The status of the parameters is pH (6.51-7.05), EC (510-600 μS.cm-1), TDS (450-590 ppm), TSS (0.0-0.034 mg.L-1), total alkalinity (80-392 mg.L-1), total acidity (224-500 mg.L-1), total hardness (348-452 mg.L-1), Ca2+ hardness (74-162 mg.L-1), free CO2 (730-1170 mg.L-1), DO (2.7-5.5 mg.L-1). However, the DO value at some points of the lake is too less (2.7 mg.L-1 and 3.7 mg.L-1) than the standard value (> 5-6 mg.L-1) of ECR, DoE, which might not be healthy for any water body and aquatic ecosystem. Other water quality parameters are within the permissible limit of WHO and ECR, DoE.
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- 2023
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11. Apixaban in Patients With Post-Myocardial Infarction Left Ventricular Thrombus: A Randomized Clinical Trial
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Ali A. Youssef, MD, Mustafa A. Alrefae, MD, Hesham H. Khalil, MD, Hisham I. Abdullah, MD, Zizi S. Khalifa, MD, Amani A. Al Shaban, MSc Pharm, Hammam A. Wali, D Pharm, Mazen R. AlRajab, MD, Omar M. Saleh, MD, and Baher N. Nashy, MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Direct oral anticoagulants are frequently used to treat post-myocardial infarction (MI) left ventricular thrombus (LVT). This study was conducted to evaluate the efficacy and safety of use of apixaban, compared to the standard warfarin therapy, in post-MI LVT. Methods: This open-label, randomized controlled trial included patients with post-acute or recent anterior wall MI with transthoracic echocardiography-confirmed LVT. Patients were randomized to receive either apixaban 5 mg twice daily or warfarin to achieve an international normalized ratio of 2-3, in addition to dual antiplatelet therapy. The primary endpoint was LVT resolution at 3 months, with a noninferiority margin of 95% for apixaban compared to warfarin. The secondary endpoint was major adverse cardiovascular events (MACE) or any relevant bleeding according to the Bleeding Academic Research Consortium (BARC) classification. Results: Fifty patients were enrolled from 3 centres. The use of dual or single antiplatelet agents was similar in the 2 groups. The number of 1-, 3-, and 6-month LVT resolutions were 10 (40.0%), 19 (76.0%), and 23 (92.0%) in the apixaban group, and 14 (56%), 20 (80.0%), and 24 (96.0%) in the warfarin group, respectively, without significant differences (P < 0.036 for noninferiority at 3 months). Patients taking warfarin required longer hospital stays and more outpatient visits. Multivariate adjustment analysis revealed left ventricular aneurysm, larger baseline LVT area and lower left ventricular ejection fraction to be independent predictors of LVT persistence at 3 months. No MACE occurred in either group; 1 BARC-2 bleeding event occurred with warfarin. Conclusions: Apixaban was not inferior to warfarin in the resolution of post-MI LVT. Résumé: Contexte: Les anticoagulants oraux directs sont souvent utilisés pour traiter un thrombus du ventricule gauche (TVG) après un infarctus du myocarde (IM). Cette étude a été réalisée afin d’évaluer l’efficacité et l’innocuité de l’apixaban, comparativement au traitement de référence par la warfarine dans les cas de TVG consécutif à un IM. Méthodologie: Cette étude en mode ouvert, contrôlée et à répartition aléatoire portait sur des patients ayant subi un IM aigu ou un IM récent de la paroi antérieure et présentant un TVG confirmé par échocardiographie transthoracique. Les patients ont été répartis aléatoirement pour recevoir l’apixaban à 5 mg deux fois par jour ou la warfarine en vue d’obtenir un ratio international normalisé de 2-3, en plus d’une bithérapie antiplaquettaire. Le critère d’évaluation principal était la résolution du TVG à trois mois, avec une marge de non-infériorité de 95 % pour l’apixaban comparativement à la warfarine. Le critère d’évaluation secondaire était la survenue d’événements cardiovasculaires indésirables majeurs ou de tout saignement associé, selon la classification du Bleeding Academic Research Consortium (BARC). Résultats: Cinquante patients provenant de trois centres ont été sélectionnés. L’utilisation d’un seul ou de deux agents antiplaquettaires était similaire dans les deux groupes. Le nombre de résolutions du TVG à 1 mois, à 3 mois et à 6 mois était de 10 (40,0 %), 19 (76,0 %) et 23 (92,0 %) respectivement dans le groupe apixaban, et de 14 (56,0 %), 20 (80,0 %) et 24 (96,0 %) respectivement dans le groupe warfarine, sans différence significative (p < 0,036 pour la non-infériorité à 3 mois). Les patients qui prenaient de la warfarine ont dû être hospitalisés plus longtemps et consulter plus souvent en externe. L’analyse multivariée sur les ajustements a révélé que l’anévrisme du ventricule gauche, plus grande zone TVG de base et une faible fraction d’éjection du ventricule gauche étaient des facteurs prédictifs indépendants de la persistance du TVG à trois mois. Aucun événement cardiovasculaire indésirable majeur ne s’est produit dans les deux groupes; un saignement de classe 2 selon le BARC s’est produit dans le groupe prenant de la warfarine. Conclusions: L’apixaban n’était pas inférieur à la warfarine dans la résolution du TVG après un IM.
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- 2023
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12. Application of combined GA3 and NAA treatments to improve yield and quality of Okra (Abelmoschus esculentus L.)
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Abdullah, Md., Anik, Sultan Mahmud, Nishi, Nusrat Jahan, Jahan, Ishrat, Khatun, Mst. Ananya, Akther, Farjana, and Rahman, Md. Hassanur
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- 2024
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13. The Role of the Vascular System in Degenerative Diseases: Mechanisms and Implications
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Abdullah Md. Sheikh, Shozo Yano, Shatera Tabassum, and Atsushi Nagai
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degenerative diseases ,vascular system ,neurodegenerative disease ,chronic kidney disease ,cardiovascular disease ,endothelial dysfunction ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Degenerative diseases, encompassing a wide range of conditions affecting various organ systems, pose significant challenges to global healthcare systems. This comprehensive review explores the intricate interplay between the vascular system and degenerative diseases, shedding light on the underlying mechanisms and profound implications for disease progression and management. The pivotal role of the vascular system in maintaining tissue homeostasis is highlighted, as it serves as the conduit for oxygen, nutrients, and immune cells to vital organs and tissues. Due to the vital role of the vascular system in maintaining homeostasis, its dysfunction, characterized by impaired blood flow, endothelial dysfunction, and vascular inflammation, emerges as a common denominator of degenerative diseases across multiple systems. In the nervous system, we explored the influence of vascular factors on neurodegenerative diseases such as Alzheimer’s and Parkinson’s, emphasizing the critical role of cerebral blood flow regulation and the blood–brain barrier. Within the kidney system, the intricate relationship between vascular health and chronic kidney disease is scrutinized, unraveling the mechanisms by which hypertension and other vascular factors contribute to renal dysfunction. Throughout this review, we emphasize the clinical significance of understanding vascular involvement in degenerative diseases and potential therapeutic interventions targeting vascular health, highlighting emerging treatments and prevention strategies. In conclusion, a profound appreciation of the role of the vascular system in degenerative diseases is essential for advancing our understanding of degenerative disease pathogenesis and developing innovative approaches for prevention and treatment. This review provides a comprehensive foundation for researchers, clinicians, and policymakers seeking to address the intricate relationship between vascular health and degenerative diseases in pursuit of improved patient outcomes and enhanced public health.
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- 2024
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14. Correction: Shibly et al. Analysis of Cerebral Small Vessel Changes in AD Model Mice. Biomedicines 2023, 11, 50
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Abu Zaffar Shibly, Abdullah Md. Sheikh, Makoto Michikawa, Shatera Tabassum, Abul Kalam Azad, Xiaojing Zhou, Yuchi Zhang, Shozo Yano, and Atsushi Nagai
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n/a ,Biology (General) ,QH301-705.5 - Abstract
In the original publication [...]
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- 2024
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15. Prevalence and risk factors of Avian Influenza Viruses among household ducks in Chattogram, Bangladesh
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Rahman, Md. Ashiqur, Belgrad, Joseph P., Sayeed, Md. Abu, Abdullah, Md. Sadeque, Barua, Shanta, Chisty, Nurun Nahar, Mohsin, Md. Abu Shoieb, Foysal, Mohammad, Hossain, Mohammad Enayet, Islam, Ariful, Akwar, Holy, and Hoque, Md Ahasanul
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- 2022
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16. Development of a Cystic Fibrosis Primary Palliative Care Intervention: Qualitative Analysis of Patient and Family Caregiver Preferences
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Melissa J Basile PhD, Lara Dhingra PhD, Stephanie DiFiglia PhD, Jennifer Polo MS, Russell Portenoy MD, Janice Wang MD, Patricia Walker MD, Brandi Middour-Oxler DNP, Rachel W Linnemann MD, Catherine Kier MD, Deborah Friedman PhD, Maria Berdella MD, Robert Abdullah MD, Lael M Yonker MD, Martha Markovitz MSW, Denis Hadjiliadis MD, Melissa Shiffman MA, LMSW, Francine Fischer, Sophie Pollinger BA, Margot Hardcastle BA, Nivedita Chaudhary MPH, and Anna M Georgiopoulos MD
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Medicine (General) ,R5-920 - Abstract
To prevent or mitigate chronic illness burden, people with cystic fibrosis (pwCF) and their family caregivers need primary (generalist-level) palliative care from the time of diagnosis forward. We used qualitative methods to explore their preferences about a screening-and-triage model (“ Improving Life with CF ”) developed to standardize this care. We purposively sampled and interviewed 14 pwCF and caregivers from 5 Improving Life with CF study sites. Thematic analysis was guided by a priori codes using the National Consensus Project's Guidelines for Quality Palliative Care. Participants included 7 adults and 2 adolescents with CF (3 with advanced disease), 4 parents, 1 partner (7 women; 5 people of color). Few were familiar with palliative care. Illness burden was described in multiple domains, including physical (e.g., dyspnea, pain), psychological (e.g., anxiety), and social (e.g., family well-being; impact on work/school). Most preferred survey-based screening with care coordination by the CF team. Preferences for screening approaches varied. PwCF and caregivers experience illness burden and are receptive to a CF-team delivered primary palliative care screening-and-triage model with flexible processes.
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- 2023
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17. Abernethy malformation (Type 1B) presenting in a 6-year-old boy with hematochezia and hematuria: A case report
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Lava Abdullah, MD, Lilav Hussein, MD, Hasan Nabil Al Houri, MD, and Lina Khouri, MD
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Abernethy malformation ,Hematochezia ,Hematuria ,Syria ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abernethy malformation (Type 1B) presenting in a 6-year-old boy with hematochezia and hematuria: a case report Abernethy malformation is a rare congenital vascular abnormality defined by the diversion of portal blood flow to the inferior vena cava or its tributaries. Clinical presentations include neonatal cholestasis, liver tumors, and encephalopathy but variables in timing and symptomatology. Herein, we present a 6-year-old boy was referred to our hospital with complaints of hematochezia, hematuria, fecal, and urinary incontinence. A diagnosis of type 1b malformation was made depending on magnetic resonance angiography and cardiac catheterization findings, which demonstrated that the superior mesenteric vein and splenic vein joined to form a common trunk measuring 38 mm diameter and then drained into the dilated inferior vena cava with the absence of portal vein abnormalities in the liver. With further investigations, we indicated the presence of many arteriovenous malformations and urogenital abnormalities. The patient was managed conservatively.
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- 2022
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18. Effect of papaya (Carica papaya) leaf extract as dietary growth promoter supplement in red hybrid tilapia (Oreochromis mossambicus × Oreochromis niloticus) diet
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Noor Khalidah Abdul Hamid, Peace Onas Somdare, Khadijah Abdullah Md Harashid, Nurul Ain Othman, Zulhisyam Abdul Kari, Lee Seong Wei, and Mahmoud A.O. Dawood
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Papaya leaf extract ,Growth promoter ,Feed additive ,Red hybrid tilapia ,Growth condition ,Biology (General) ,QH301-705.5 - Abstract
The purpose of this experiment was to examine the potential use of Carica papaya leaf extract as a supplement to promote growth and improve feed utilization in red hybrid tilapia. Five diets were formulated containing isolipidic (80 g/kg) and isonitrogenic (350 g/kg) levels. All feeds contained similar types and amounts of raw materials but differed in the inclusion of papaya leaf extract (0, 5, 10, 20 and 40 g/kg feed). The initial size of fish used was 2.3 ± 0.01 g. Each diet was performed in triplicate tanks, and the feeding period was 12 weeks. Fish fed diet containing 2% papaya leaf extract (PLE) had the highest final weight, 31.14 ± 1.47 g, followed by 1% PLE (27.27 ± 1.75 g). These two diets (1% and 2%) were also showed significant improvements of weight gain, SGR, and feed efficiency of the red hybrid tilapia (p
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- 2022
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19. Role of manganite in enhancing dielectric cum magnetic properties of BTFO-LSMO composites
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Jena, Rasmita, Chandrakanta, K., Pal, P., Abdullah, Md. F., Sahu, D. P., Kaushik, S. D., Sharma, R. K., and Singh, A. K.
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- 2022
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20. Proteomic analysis of extracellular vesicles enriched serum associated with future ischemic stroke
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Shingo Mitaki, Yasuko Wada, Abdullah Md. Sheikh, Shuhei Yamaguchi, and Atsushi Nagai
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Medicine ,Science - Abstract
Abstract Identifying new biomarkers beyond the established risk factors that make it possible to predict and prevent ischemic stroke has great significance. Extracellular vesicles are powerful cell‒cell messengers, containing disease-specific biomolecules, which makes them powerful diagnostic candidates. Therefore, this study aimed to identify proteins derived from extracellular vesicles enriched serum related to future ischemic stroke events, using a proteomic method. Of Japanese subjects who voluntarily participated in health checkups at our institute a number of times, 10 subjects (6 males and 4 females, age: 64.2 ± 3.9 years) who developed symptomatic ischemic stroke (7.3 ± 4.4 years’ follow-up) and 10 age‒sex matched controls without brain lesions (6.7 ± 2.8 years’ follow-up) were investigated. Extracellular vesicles enriched fractions were derived from serum collected at the baseline visit. Differentially expressed proteins were evaluated using isobaric tagging for relative and absolute protein quantification (iTRAQ)-based proteomic analysis. Of the 29 proteins identified, alpha-2-macroglobulin, complement C1q subcomponent subunit B, complement C1r subcomponent, and histidine-rich glycoprotein were significantly upregulated (2.21-, 2.15-, 2.24-, and 2.16-fold, respectively) in subjects with future ischemic stroke, as compared with controls. Our study supports the concept of serum-derived extracellular vesicles enriched fractions as biomarkers for new-onset stroke. These proteins may be useful for prediction or for targeted therapy.
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- 2021
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21. Rapid identification of plasmalogen molecular species using targeted multiplexed selected reaction monitoring mass spectrometry
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Abul Kalam Azad, Hironori Kobayashi, Abdullah Md. Sheikh, Harumi Osago, Hiromichi Sakai, Md. Ahsanul Haque, Shozo Yano, and Atsushi Nagai
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LC-MS/MS ,Targeted multiplexed SRM/MS‘ ,Plasmalogens ,Phospholipids ,Identification ,Quantification ,Medical technology ,R855-855.5 - Abstract
Plasmalogens (Pls) levels are reported to be altered in several neurological and metabolic diseases. Identification of sn-1 fatty alcohols and sn-2 fatty acids of different Pls species is necessary to determine the roles and mechanisms of action of Pls in different diseases. Previously, full-scan tandem mass spectrometry (MS/MS) was used for this purpose but is not effective for low-abundance Pls species. Recently, multiplexed selected reaction monitoring MS (SRM/MS) was found to be more selective and sensitive than conventional full-scan MS/MS for the identification of low-abundance compounds. In the present study, we developed a liquid chromatography (LC)-targeted multiplexed SRM/MS system for the identification and quantification of different Pls choline (Pls-PC) and Pls ethanolamine (Pls-PE) species. We determined five precursor-product ion transitions to identify sn-1 and sn-2 fragments of each Pls species. Consequently, sn-1 and sn-2 fatty acyl chains of 22 Pls-PC and 55 Pls-PE species were identified in mouse brain samples. Among them, some species had C20:0 and C20:1 fatty alcohols at the sn-1 position. For quantification of Pls species in mouse brain samples, a single SRM transition was employed. Thus, our results suggest that the LC-targeted multiplexed SRM/MS system is very sensitive for the identification and quantification of low-abundance lipids such as Pls, and is thus expected to make a significant contribution to basic and clinical research in this field in the future.
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- 2021
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22. In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin
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Moudhi Alroomi MD, Ahmad Alsaber MD, Bader Al-Bader MD, Farah Almutairi MD, Haya Malhas MD, Jiazhu Pan MD, Kobalava D. Zhanna MD, Maryam Ramadhan MD, Mohammad Al Saleh MD, Mohammed Abdullah MD, Naser Alotaibi MD, Noor AlNasrallah MD, Rajesh Rajan MD, Soumoud Hussein MD, and Wael Aboelhassan MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Аbstrасt Objectives This study aimed to investigate in-hospital mortality rates in patients with coronavirus disease (COVID-19) according to enoxaparin and heparin use. Methods This retrospective cohort study included 962 patients admitted to two hospitals in Kuwait with a confirmed diagnosis of COVID-19. Cumulative all-cause mortality rate was the primary outcome. Results A total of 302 patients (males, 196 [64.9%]; mean age, 57.2 ± 14.6 years; mean body mass index, 29.8 ± 6.5 kg/m 2 ) received anticoagulation therapy. Patients receiving anticoagulation treatment tended to have pneumonia (n = 275 [91.1%]) or acute respiratory distress syndrome (n = 106 [35.1%]), and high D-dimer levels (median [interquartile range]: 608 [523;707] ng/mL). The mortality rate in this group was high (n = 63 [20.9%]). Multivariable logistic regression, the Cox proportional hazards, and Kaplan-Meier models revealed that the use of therapeutic anticoagulation agents affected the risk of all-cause cumulative mortality. Conclusion Age, hypertension, pneumonia, therapeutic anticoagulation, and methylprednisolone use were found to be strong predictors of in-hospital mortality. In elderly hypertensive COVID-19 patients on therapeutic anticoagulation were found to have 2.3 times higher risk of in-hospital mortality. All cause in-hospital mortality rate in the therapeutic anticoagulation group was up to 21%.
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- 2022
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23. Structural, magnetic, and magnetodielectric correlations in multiferroic Bi5Ti3FeO15
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Jena, Rasmita, Chandrakanta, K., Abdullah, Md. F., Pal, P., Kaushik, S. D., and Singh, A. K.
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- 2021
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24. Dielectric relaxation and conduction mechanism in Aurivillius ceramic Bi5Ti3FeO15
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Jena, Rasmita, Chandrakanta, K., Pal, P., Abdullah, Md. F., Kaushik, S. D., and Singh, A. K.
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- 2021
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25. Rho-Kinase inhibition decreases focal cerebral ischemia-induced glial activation in rats
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Abdullah Md Sheikh, Shozo Yano, Shingo Mitaki, Shatera Tabassum, Shuhei Yamaguchi, and Atsushi Nagai
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background Rho-kinase inhibition in a rat middle cerebral artery occlusion (MCAO) model is reported to improve neurological functions and decrease infarction size. Objective The objective of this study is to investigate the underlying mechanisms of such improvement by evaluating the effects of Rho-kinase inhibition on astrocytes and microglial accumulation and activation in this condition. Methods Adult male Sprague-Dawley (SD) rats were used to generate the MCAO model, which received an I.P injection of a chemical Rho-kinase inhibitor (Fasudil- 5 mg/kg/day) or vehicle (PBS) for 2 and 4 days. Results Fasudil treatment significantly decreased the stroke volumes and water content in the lesion areas, as revealed by MRI. Immunostaining and Western blotting results demonstrated that Fasudil significantly decreased the levels of Aquaporin-4, a water channel protein. The number of GFAP + astrocytes and Iba-1 + macrophage/microglia was decreased in the lesion areas. Proinflammatory transcription factor NF-κB protein levels were decreased in the Fasudil group 2 days after MCAO. Also, proinflammatory mediators including TNF-α, IL-1β, and iNOS levels were decreased. In vitro migration study using a human microglial cell line (HMO6) confirmed the inhibitory effects of Fasudil on the process. Fasudil also decreased combined IL-1β and IFNγ-induced NF-κB nuclear translocation in HMO6. Moreover, Fasudil transiently decreased combined IL-1β and IFNγ-induced iNOS, TNFα, and IL-1β mRNA levels in HMO6. Conclusion Our study demonstrates the inhibitory effects of Rho-kinase on NF-κB-mediated glial activation and cerebral edema, which might be a promising therapeutic target in acute cerebral ischemia conditions.
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- 2022
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26. Deep learning based question answering system in Bengali
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Tasmiah Tahsin Mayeesha, Abdullah Md Sarwar, and Rashedur M. Rahman
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natural language processing ,question answering ,reading comprehension ,Telecommunication ,TK5101-6720 ,Information technology ,T58.5-58.64 - Abstract
Recent advances in the field of natural language processing has improved state-of-the-art performances on many tasks including question answering for languages like English. Bengali language is ranked seventh and is spoken by about 300 million people all over the world. But due to lack of data and active research on QA similar progress has not been achieved for Bengali. Unlike English, there is no benchmark large scale QA dataset collected for Bengali, no pretrained language model that can be modified for Bengali question answering and no human baseline score for QA has been established either. In this work we use state-of-the-art transformer models to train QA system on a synthetic reading comprehension dataset translated from one of the most popular benchmark datasets in English called SQuAD 2.0. We collect a smaller human annotated QA dataset from Bengali Wikipedia with popular topics from Bangladeshi culture for evaluating our models. Finally, we compare our models with human children to set up a benchmark score using survey experiments.
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- 2021
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27. Biological investigations of the methanol extract of Tetrastigma leucostaphylum (Dennst.) Alston ex Mabb. (Vitaceae) : In vivo and in vitro approach
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Sajib Rudra, Md. Solaman Uddin Sawon, Nazim Uddin Emon, Safaet Alam, Syed Mohammed Tareq, Mohammad Nazmul Islam, Mir Md. Rokib Uddin, Abdullah Md Sazid Chowdhury, Abu Nazer Hasbe, Mohammad Shakil, Shahenur Alam Sakib, and Mohammed Aktar Sayeed
- Subjects
tetrastigma leucostaphylum ,writhing ,formalin ,clot lysis ,tubifex tubifex ,Biotechnology ,TP248.13-248.65 - Abstract
Tetrastigma leucostaphylum (Family: Vitaceae) is popular for its medicinal value in Bangladeshi tribal communities. This study aims to investigate several pharmacological values of methanol extract of T. leucostaphylum (METL). In vivo analgesic and anti-inflammatory researches have been implemented by using acetic acid-induced writhing and formalin-induced paw licking test protocols in mice. Furthermore, in vitro thrombolytic and anthelmintic studies have been performed by following the blood clot lysis method and nematode mortality measurement method. In the in vivo study, METL did not minimize the acetic acid-induced writhes prominently but significantly attenuate both the peripheral and inflammatory pain in mice in a dose-dependent manner. In early and late phase, METL 400 (mg/kg, b.w; p.o) showed 39.63 % and 48.73 % paw licking inhibition. Again, METL (100 µL) reflected 56.62 % clot lysis in thrombolytic research. Besides, METL causes the death of nematodes in a dose-dependent manner. The bioassay of the methanol extract of T. leucostaphylum justified the analgesic, anti-inflammatory, thrombolytic and anthelmintic activities of the crude extract and finally suggests the test extract as a wellspring of anti-inflammatory, thrombolytic and anthelmintic agents as a crude drug source. [ J Adv Biotechnol Exp Ther 2020; 3(3.000): 216-224]
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- 2020
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28. Alzheimer’s Amyloid β Peptide Induces Angiogenesis in an Alzheimer’s Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions
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Abdullah Md. Sheikh, Shozo Yano, Shatera Tabassum, Shingo Mitaki, Makoto Michikawa, and Atsushi Nagai
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Alzheimer’s disease ,amyloid β peptide ,angiogenesis ,placental growth factor ,angiopoietin 2 ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Increased angiogenesis, especially the pathological type, has been documented in Alzheimer’s disease (AD) brains, and it is considered to be activated due to a vascular dysfunction-mediated hypoxic condition. To understand the role of the amyloid β (Aβ) peptide in angiogenesis, we analyzed its effects on the brains of young APP transgenic AD model mice. Immunostaining results revealed that Aβ was mainly localized intracellularly, with very few immunopositive vessels, and there was no extracellular deposition at this age. Solanum tuberosum lectin staining demonstrated that compared to their wild-type littermates, the vessel number was only increased in the cortex of J20 mice. CD105 staining also showed an increased number of new vessels in the cortex, some of which were partially positive for collagen4. Real-time PCR results demonstrated that placental growth factor (PlGF) and angiopoietin 2 (AngII) mRNA were increased in both the cortex and hippocampus of J20 mice compared to their wild-type littermates. However, vascular endothelial growth factor (VEGF) mRNA did not change. Immunofluorescence staining confirmed the increased expression of PlGF and AngII in the cortex of the J20 mice. Neuronal cells were positive for PlGF and AngII. Treatment of a neural stem cell line (NMW7) with synthetic Aβ1–42 directly increased the expression of PlGF and AngII, at mRNA levels, and AngII at protein levels. Thus, these pilot data indicate that pathological angiogenesis exists in AD brains due to the direct effects of early Aβ accumulation, suggesting that the Aβ peptide regulates angiogenesis through PlGF and AngII expression.
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- 2023
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29. Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults
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Jubo Bhuiya, Yoshitomo Notsu, Hironori Kobayashi, Abu Zaffar Shibly, Abdullah Md. Sheikh, Ryota Okazaki, Kazuto Yamaguchi, Atsushi Nagai, Toru Nabika, Takafumi Abe, Masayuki Yamasaki, Minoru Isomura, and Shozo Yano
- Subjects
L-carnitine ,trimethylamine-N-oxide (TMAO) ,trimethyllysine (TML) ,atherosclerosis ,intima–media thickness (IMT) ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Recent evidence suggests that trimethylamine-N-oxide (TMAO), a metabolite of L-carnitine and choline, is linked to atherosclerosis and cardiovascular diseases. As TMAO content is very high in fish, we raised the following question: why do Japanese people, who consume lots of fish, show a low risk of atherosclerosis? To address this question, we investigated the effects of TMAO and other L-carnitine-related metabolites on carotid intima–media thickness (IMT). Participants were recruited from a small island and a mountainous region. Plasma L-carnitine, γ-butyrobetaine (γBB), TMAO, trimethyllysine (TML), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) levels were measured using liquid or gas chromatography–mass spectrometry. Plasma L-carnitine concentration was higher in men than in women. TMAO and TML were significantly higher in the residents of the island than in the mountainous people. In multiple linear regression analyses in all participants, TML showed a significant inverse association with max-IMT and plaque score (PS), whereas TMAO did not show any associations. In women, L-carnitine was positively associated with max-IMT and PS. TMAO was correlated with both EPA and DHA levels, implying that fish is a major dietary source of TMAO in Japanese people. Our study found that plasma TMAO was not an apparent risk factor for atherosclerosis in elderly Japanese people, whereas a low level of TML might be a potential risk. L-carnitine may be a marker for atherosclerosis in women.
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- 2023
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30. Analysis of Cerebral Small Vessel Changes in AD Model Mice
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Abu Zaffar Shibly, Abdullah Md. Sheikh, Makoto Michikawa, Shatera Tabassum, Abul Kalam Azad, Xiaojing Zhou, Yuchi Zhang, Shozo Yano, and Atsushi Nagai
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Alzheimer’s disease (AD) ,APP transgenic mouse ,amyloid β ,vessel leakage ,blood brain barrier (BBB) ,Biology (General) ,QH301-705.5 - Abstract
Amyloid β (Aβ) peptide is deposited in the brains of sporadic Alzheimer’s disease (AD) due to impaired vessel-dependent clearance. To understand the mechanisms, we investigated time-dependent cerebrovascular changes in AD model mice. Cerebrovascular and other pathological changes were analyzed in AD model mice (J20 strain) aging from 2 to 9 months by immunostaining. At 2 months, Aβ was only intraneuronal, whereas vessels were positive from 3 months in J20 mice. Compared to wild-type (WT), vessel density was increased at 2 months but decreased at 9 months in J20 mice, claudin-5 levels were decreased, and vascular endothelial growth factor (VEGF) levels were increased in the cortex and hippocampus of J20 mice brain at all time points. Albumin extravasation was evident from 3 months in J20 brains. Collagen 4 was increased at 2 and 3 months. Aquaporin 4 was spread beyond the vessels starting from 3 months in J20, which was restricted around the vessel in wild-type mice. In conclusion, the study showed that an early decrease in claudin-5 was associated with VEGF expression, indicating dysfunction of the blood–brain barrier. Decreased claudin-5 might cause the leakage of blood constituents into the parenchyma that alters astrocyte polarity and its functions.
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- 2022
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31. iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes
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Xiaojing Zhou, Abdullah Md. Sheikh, Ken-ichi Matsumoto, Shingo Mitaki, Abu Zaffar Shibly, Yuchi Zhang, Garu A, Shozo Yano, and Atsushi Nagai
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Alzheimer’s disease ,urine exosomes ,amyloid beta ,iTRAQ ,proteomic analysis ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Alzheimer’s disease (AD) is a common dementia disease in the elderly. To get a better understanding of the pathophysiology, we performed a proteomic analysis of the urine exosomes (U-exo) in AD model mice (J20). The polymer precipitation method was used to isolate U-exo from the urine of 3-month-old J20 and wild-type (WT) mice. Neuron-derived exosome (N-exo) was isolated from U-exo by immunoprecipitation. iTRAQ-based MALDI TOF MS/MS was used for proteomic analysis. The results showed that compared to WT, the levels of 61 and 92 proteins were increased in the J20 U-exo and N-exo, respectively. Gene ontology enrichment analysis demonstrated that the sphingolipid catabolic process, ceramide catabolic process, membrane lipid catabolic process, Aβ clearance, and Aβ metabolic process were highly enriched in U-exo and N-exo. Among these, Asah1 was shown to be the key protein in lipid metabolism, and clusterin, ApoE, neprilysin, and ACE were related to Aβ metabolism and clearance. Furthermore, protein–protein interaction analysis identified four protein complexes where clusterin and ApoE participated as partner proteins. Thus, J20 U-exo and N-exo contain proteins related to lipid- and Aβ-metabolism in the early stages of AD, providing a new insight into the underlying pathological mechanism of early AD.
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- 2022
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32. Proteomic analysis of extracellular vesicles enriched serum associated with future ischemic stroke
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Mitaki, Shingo, Wada, Yasuko, Sheikh, Abdullah Md., Yamaguchi, Shuhei, and Nagai, Atsushi
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- 2021
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33. Unravelling the nature of magneto-electric coupling in room temperature multiferroic particulate (PbFe0.5Nb0.5O3)–(Co0.6Zn0.4Fe1.7Mn0.3O4) composites
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Bhoi, Krishnamayee, Mohanty, H. S., Ravikant, Abdullah, Md. F., Pradhan, Dhiren K., Babu, S. Narendra, Singh, A. K., Vishwakarma, P. N., Kumar, A., Thomas, R., and Pradhan, Dillip K.
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- 2021
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34. COVID-19 pneumonia identified by CT of the abdomen: A report of three emergency patients presenting with abdominal pain
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Sherif Abolyazid, MD & MSc (Radiology), Shireen Alshareef, SBEM & JBEM, Nouf Abdullah, MD & RCPSC, Abdalla Khalil, FRCGP, MRCEM (UK), Arab BIM & DTM, Nashaat Hamza, MD, ABIM & ABID, and Ahmed Salem, Mb BCh & MSc (EM)
- Subjects
COVID-19 pneumonia ,COVID-19 gastrointestinal symptoms ,COVID-19 Polymerase chain reaction testing ,CT abdomen in COVID-19 patients ,Sensitivity of CT in COVID-19 patients' detection ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Patients with COVID-19 infection may present to the Emergency Department (ED) with gastrointestinal complaints and no respiratory symptoms. We are presenting 3 patients who came to the ED with abdominal pain; and the computed tomography [CT] of the abdomen showed findings suggestive of COVID-19 pneumonia.A 65-year-old male patient presented with symptoms of urinary tract infection and left renal angle tenderness. A 42-year-old male patient presented with right flank pain postextracorporeal shock wave lithotripsy. A 71-year-old male known to have type 2 diabetes mellitus and who had had whipple surgery for a neoplasm of the head of the pancreas presented with a painful epigasteric swelling. The 3 patients had positive COVID-19 polymerase chain reaction (PCR) tests and mild-to-moderate illness, and were discharged home after 2 weeks with a good recovery. The first patient had a false negative early PCR test, which turned positive on 2 repetitions of the test.A systematic review of CT abdomen, including inspection of the lung bases using the lung window in all CT abdomen, is essential to detect findings suggestive of COVID-19 pneumonia in patients requiring a CT abdomen study. As proven in the literature, CT findings of COVID-19 pneumonia have a higher sensitivity than the PCR test.
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- 2020
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35. Evidence of room-temperature magnetodielectric effect in brownmillerite KBiFe2O5 through magnetic, complex dielectric, and impedance study
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Chandrakanta, K., Jena, R., Pal, P., Abdullah, Md. F., Mohapatra, S. R., Kaushik, S. D., and Singh, A. K.
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- 2020
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36. Water and environmental sustainability in Langkawi UNESCO Global Geopark, Malaysia: issues and challenges towards sustainable development
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Elfithri, Rahmah, Mokhtar, Mazlin Bin, and Abdullah, Md Pauzi
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- 2021
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37. Flooding crisis in Bangladesh: urgent measures required
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Islam, Md. Jahidul, Abdullah, Md Shahriar, and Alam, Morshed
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- 2024
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38. Endoscopic Reconstruction of Skull Base Defects Using Tutoplast
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Ghassan Alokby MD, Kholoud Mohammed AlAmari MD, Jamal Mohammed S. Abdullah MD, Mohammed Tayed Hazazi MD, and Fawaz Makki MD, MSc, FRCS(c)
- Subjects
Otorhinolaryngology ,RF1-547 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background Various graft materials that are classified as autografts, xenografts, and allografts based on their origin have been used to endoscopically repair skull base defects. Tutoplast® (Tutogen Medical GmbH), an allogeneic natural collagen matrix, is processed through chemical sterilization that preserves tissue biocompatibility and structural integrity. Objective To study the safety and efficacy of Tutoplast Fascia Lata and Tutoplast Temporalis Fascia® as primary graft materials in the endoscopic reconstruction of skull base defects of different sizes and etiologies and to compare the outcomes with those of other traditional graft materials based on our experience. Methods This is a multi-center retrospective chart review of patients who underwent cerebrospinal fluid leak (CSF) endoscopic reconstruction with Tutoplast Fascia Lata or Tutoplast Temporalis Fascia as either a stand-alone reconstruction material or a part of a multilayer reconstruction depending on the defect at Prince Sultan Military Medical City and King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia, between 2017 and 2020. Our inclusion criteria were CSF leak repair with Tutoplast and a transnasal endoscopic approach. We reviewed demographic data, intraoperative and postoperative complications, repair materials, repair failure, defect size and location. Results Tutoplast® was used as the primary graft material in 33 cases. Our main outcome was repair success with lack of post operative CSF leak, observed in 30 cases (90.9%). There was no significant association between postoperative CSF leaks and factors including different defect sizes, defect sites, demographic data, hospitalization duration, or postoperative radiation in oncological cases. Conclusion Tutoplast alone or in combination with other materials can be used safely and effectively for skull base defects repair.
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- 2021
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39. A study of critical minima and spin polarization in the e±–Ba elastic scattering
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Abdullah, Md. Nure Alam, Kumar, Ashok, Haque, Abul Kalam Fazlul, and Alfaz Uddin, M.
- Published
- 2020
- Full Text
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40. Epidemiological assessment of clinical poultry cases through the government veterinary hospital-based passive surveillance system in Bangladesh: a case study
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Rahman, Md. Ashiqur, Rahman, Md. Mahbubur, Abdullah, Md. Sadeque, Sayeed, Md. Abu, Rashid, Md. Harun, Mahmud, Rashed, Belgrad, Joseph P., and Hoque, Md. Ahasanul
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- 2019
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41. Time-Dependent Analysis of Plasmalogens in the Hippocampus of an Alzheimer’s Disease Mouse Model: A Role of Ethanolamine Plasmalogen
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Abul Kalam Azad, Abdullah Md. Sheikh, Md. Ahsanul Haque, Harumi Osago, Hiromichi Sakai, Abu Zaffar Shibly, Shozo Yano, Makoto Michikawa, Shahdat Hossain, Shatera Tabassum, Garu A., Xiaojing Zhou, Yuchi Zhang, and Atsushi Nagai
- Subjects
LC-SRM/MS ,plasmalogen ,ROS ,phagocytosis ,GNPAT ,glial cells ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Plasmalogens are alkenyl-acyl glycerophospholipids and decreased in post-mortem Alzheimer’s disease (AD) brains. The aim of this study is to investigate the time-dependent changes of plasmalogens in the hippocampus of an AD model mouse (J20). Plasmalogen levels at 3, 6, 9, 12 and 15 months were analyzed by liquid-chromatography-targeted-multiplexed-selected-reaction-monitoring-tandem-mass-spectrometry (LC-SRM/MS). Reactive oxygen species (ROS) levels were evaluated using dichlorofluorescein diacetate (DCF-DA). Plasmalogen synthesizing enzyme glycerone-phosphate O-acyltransferase (GNPAT) and late endosome marker Rab7 levels were quantified by Western blotting. GNPAT localization, changes of neuronal and glial cell numbers were evaluated by immunostaining. Compared to wild-type mice (WT), total plasmalogen-ethanolamine, but not plasmalogen-choline levels, were increased at 9 months and subsequently decreased at 15 months in J20 mice. A principal component analysis of plasmalogen-ethanolamine species could separate WT and J20 mice both at 9 and 15 months. Both GNPAT and Rab7 protein were increased in J20 mice at 9 months, whereas GNPAT was decreased at 15 months. ROS levels were increased in J20 mice except for 9 months. Our results suggest that increased plasmalogen-ethanolamine could counteract ROS levels and contribute to the phagocytosis process in J20 mice at 9 months. Such results might indicate a transient protective response of plasmalogen-ethanolamine in AD conditions.
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- 2021
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42. Aggregation of Cystatin C Changes Its Inhibitory Functions on Protease Activities and Amyloid β Fibril Formation
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Abdullah Md. Sheikh, Yasuko Wada, Shatera Tabassum, Satoshi Inagaki, Shingo Mitaki, Shozo Yano, and Atsushi Nagai
- Subjects
Cystatin C ,aggregation ,cathepsin activity ,Amyloid β ,neurodegeneration ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Cystatin C (CST3) is an endogenous cysteine protease inhibitor, which is implicated in cerebral amyloid angiopathy (CAA). In CAA, CST3 is found to be aggregated. The purpose of this study is to investigate whether this aggregation could alter the activity of the protein relevant to the molecular pathology of CAA. A system of CST3 protein aggregation was established, and the aggregated protein was characterized. The results showed that CST3 aggregated both at 80 °C without agitation, and at 37 °C with agitation in a time-dependent manner. However, the levels of aggregation were high and appeared earlier at 80 °C. Dot-blot immunoassay for oligomers revealed that CST3 could make oligomeric aggregates at the 37 °C condition. Electron microscopy showed that CST3 could make short fibrillary aggregates at 37 °C. Cathepsin B activity assay demonstrated that aggregated CST3 inhibited the enzyme activity less efficiently at pH 5.5. At 7.4 pH, it lost the inhibitory properties almost completely. In addition, aggregated CST3 did not inhibit Aβ1-40 fibril formation, rather, it slightly increased it. CST3 immunocytochemistry showed that the protein was positive both in monomeric and aggregated CST3-treated neuronal culture. However, His6 immunocytochemistry revealed that the internalization of exogenous recombinant CST3 by an astrocytoma cell culture was higher when the protein was aggregated compared to its monomeric form. Finally, MTT cell viability assay showed that the aggregated form of CST3 was more toxic than the monomeric form. Thus, our results suggest that aggregation may result in a loss-of-function phenotype of CST3, which is toxic and responsible for cellular degeneration.
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- 2021
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43. Efficient energy flow criteria of hybrid solar battery packs grid for electric vehicle rapid-charging facility
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Arfeen, Zeeshan A., Abdullah, Md Pauzi, Sheikh, Usman Ullah, Siddique, Abubakar, Raheem, Abdur, and Kausar, Mehreen
- Abstract
Rapid growth in electrical transportation and a shift towards clean energy from distributed renewable energy sources are sustainable options to crack down on the demand and usage of electricity. In this paper, grid-assisted electric vehicle (EV) rapid charging facilities empowered by photovoltaic modules and battery stacks are utilised. Further, an effective interactive mechanism between EV and renewable power sources to improve system reliability – 15 efficient modes of charging are employed for the grid-connected charging station. Moreover, for long run of the charging facility, sizing components of the EV charging facilities are optimised by meta-heuristic barebones Harris hawk optimisation with a net profit of US 0.0084/kWh in criteria of no profit/loss. This is also confirmed by the swarm-style memetic grasshopper optimisation algorithm and multifarious particle swarm optimisation.
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- 2023
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44. Blockchain-based management of demand response in electric energy grids: A systematic review
- Author
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Junaidi, Nazreen, Abdullah, Md Pauzi, Alharbi, Bader, and Shaaban, Mohamed
- Abstract
The complexities associated with modern energy grids, including high penetration levels of renewable energy sources at the end use customers, the proliferation of electric vehicles (EVs), as well as decentralized energy management systems and energy data portals and services, require secure, reliable and cost-effective new platforms to administer such systems in a transparent manner. Blockchain technology can address such challenging complexities efficiently. This paper presents a thorough literature review of all potential blockchain applications in electric energy systems. First, all potential blockchain application possibilities and constraints in electric energy systems have been identified. Then, the implementations of blockchain technology in power systems are divided into various categories, such as demand response (DR), EVs, decentralized energy management, energy trading and distributed renewable energy. A detailed literature analysis is conducted by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in a systematic approach using credible and reliable database systems such as IEEE Xplore, ScienceDirect, and Scopus to highlight current advancements in blockchain technology uses in electric energy systems particularly in DR, as well as future potential and existing problems. The paper is divided into three parts. The first part lists the important publications that have delved into the implementation of Blockchain in demand response. Trends of Blockchain applications in other electric energy system areas are detailed in the second section. The final part highlights the evolution and advancement of blockchain-based electric energy systems including favourable attributes of structures and designs, as well as the challenges and future trends.
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- 2023
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45. Association between cystatin C gene polymorphism and the prevalence of white matter lesion in elderly healthy subjects
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Maniwa, Kyohei, Yano, Shozo, Sheikh, Abdullah Md., Onoda, Keiichi, Mitaki, Shingo, Isomura, Minoru, Mishima, Seiji, Yamaguchi, Shuhei, Nabika, Toru, and Nagai, Atsushi
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- 2020
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46. Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study
- Author
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Garu A, Shozo Yano, Abdullah Md Sheik, Aorigele Yu, Kenta Okuyama, Miwako Takeda, Kunie Kohno, Masayuki Yamasaki, Minoru Isomura, Toru Nabika, and Atsushi Nagai
- Subjects
fracture risk ,fall ,elderly ,multimorbidity ,logistic regression analysis ,Medicine - Abstract
Fragility fractures (FFxs), which are a common musculoskeletal injury in older adults, is associated with an increased frequency of falls. Both FFxs and falls may result from drugs, habits, and co-occurring diseases. We aimed to evaluate the effects of various diseases on the risk of FFx. This retrospective study included 1420 individuals aged ≥60 years. We evaluated the history of clinical FFx and diseases using a detailed questionnaire and a health examination. The risk of comorbidities was assessed using the Age-Adjusted Charlson Comorbidity (AAC) Index. We performed binary logistic regression analysis to determine the risk of FFx and falls after adjusting for covariates. In elderly men, the incidence of FFx positively correlated with rheumatoid arthritis and parent’s hip fracture. For elderly women, the incidence of FFx positively correlated with rheumatoid arthritis and antihypertensive drugs but was inversely associated with dyslipidemia and antilipidemic drugs. The FFX risk of older adults with an AAC Index ≥6 was higher than those with an AAC Index of 1–3. In addition, the AAC Index and falls were independently and strongly associated with a higher risk of FFx. Taken together, multimorbidity increases the risk of clinical FFx independent of falls in the community-dwelling elderly population.
- Published
- 2021
- Full Text
- View/download PDF
47. Removal of simvastatin from aqueous solution by electrochemical process using graphite-PVC as anode: A case study of evaluation the toxicity, kinetics and chlorinated by-products
- Author
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Mussa, Zainab H., Al-Qaim, Fouad F., Othman, Mohamed R., and Abdullah, Md P.
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- 2016
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48. Healing Trauma and Reasserting Identity through Remembrance in Joanne Fedler’s The Dreamcloth
- Author
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Abdullah Md Abu Shahid
- Subjects
transgenerational trauma ,trauma fiction ,repressed memory ,marginalization ,identity ,Philology. Linguistics ,P1-1091 - Abstract
The aim of this article is to analyse the role of memory in generating, transmitting and coming to terms with trauma, and the importance of exploring history, and talking about and sharing traumatic events in the process of healing in Joan Fedler’s The Dreamcloth (2005). In the novel, Maya’s memories of her unrequited lesbian relationship with her beloved Rochel, oppression by the traditional structures of her family and Jewish community, her forced marriage with Yankel, and her being raped by him are responsible for her trauma on a personal level, whereas her forced relocation to South Africa in order to flee from the Holocaust is responsible for her trauma on a communal level. Mia, the protagonist and the grand-daughter of Maya, suffers from the transgenerational trauma of her grandmother, is haunted by her ghost, and also symbolically represents the traumatized Jewish community. She cannot relate to her own Jewish South African identity and thus tries to avoid being reminded of her historical background. Mia recovers from her trauma by exploring her history, solving the riddles of the past and sharing the traumatic memories of the past.
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- 2017
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49. Fluids, cages, and boisterous femininity: The grotesque transgression of patriarchal norms in Angela Carter’s Nights at the Circus
- Author
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Abdullah Md Abu Shahid
- Subjects
carnivalesque ,masculinity ,grotesque femininity ,patriarchal constraint ,Language and Literature - Abstract
The article will show that in Nights at the Circus, Carter’s use of the themes of food consumption and excrement operate as both a grotesque means of emancipation from a feminine point-of-view, and a carnivalesque challenge to subversive patriarchal norms and deconstruction of arbitrary patriarchal hierarchies. By turning the simple act of eating into boisterous spectacle, and by handling a bottle of champagne and water hose in a disturbingly masculine manner, Fevvers transgresses the boundary between masculinity and femininity, sheds the patriarchal constraints imposed upon femininity, and thus achieves agency and emancipation. Since she is not able to acquire biological signifier of masculinity, she achieves the transgression of the binary entirely through the performative carnivalesque. The article will also discuss that the overflowing nature of grotesque femininity (both physical and behavioral) enables the female characters to speak and act at their own will, and thus performs as a means of critiquing Victorian patriarchal cultural norms.
- Published
- 2017
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50. Evaluation of autonomic functions of patients with multiple system atrophy and Parkinson’s disease by head-up tilt test
- Author
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Watano, Chikako, Shiota, Yuri, Onoda, Keiichi, Sheikh, Abdullah Md, Mishima, Seiji, Nitta, Eri, Yano, Shozo, Yamaguchi, Shuhei, and Nagai, Atsushi
- Published
- 2017
- Full Text
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