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1. The Ni isotopic composition of Ryugu reveals a common accretion region for carbonaceous chondrites

Author

Spitzer, Fridolin, Kleine, Thorsten, Burkhardt, Christoph, Hopp, Timo, Yokoyama, Tetsuya, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel M. O'D., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, Morita, Mayu, Moynier, Fréderic, Motomura, Kazuko, Nakai, Izumi, Nagashima, Kazuhide, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

The isotopic compositions of samples returned from Cb-type asteroid Ryugu and Ivuna-type (CI) chondrites are distinct from other carbonaceous chondrites, which has led to the suggestion that Ryugu and CI chondrites formed in a different region of the accretion disk, possibly around the orbits of Uranus and Neptune. We show that, like for Fe, Ryugu and CI chondrites also have indistinguishable Ni isotope anomalies, which differ from those of other carbonaceous chondrites. We propose that this unique Fe and Ni isotopic composition reflects different accretion efficiencies of small FeNi metal grains among the carbonaceous chondrite parent bodies. The CI chondrites incorporated these grains more efficiently, possibly because they formed at the end of the disk's lifetime, when planetesimal formation was also triggered by photoevaporation of the disk. Isotopic variations among carbonaceous chondrites may thus reflect fractionation of distinct dust components from a common reservoir, implying CI chondrites and Ryugu may have formed in the same region of the accretion disk as other carbonaceous chondrites., Comment: Published open access in Science Advances

Published
2024
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3. Water circulation in Ryugu asteroid affected the distribution of nucleosynthetic isotope anomalies in returned sample.

Author

Yokoyama, Tetsuya, Wadhwa, Meenakshi, Iizuka, Tsuyoshi, Rai, Vinai, Gautam, Ikshu, Hibiya, Yuki, Masuda, Yuki, Haba, Makiko, Fukai, Ryota, Hines, Rebekah, Phelan, Nicole, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel, Amari, Sachiko, Amelin, Yuri, Bajo, Ken-Ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard, Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew, Di Rocco, Tommaso, Fujiya, Wataru, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary, Ichida, Kiyohiro, Ireland, Trevor, Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko, Kitajima, Koki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander, Liu, Ming-Chang, McKeegan, Kevin, Morita, Mayu, Motomura, Kazuko, Moynier, Frédéric, Nakai, Izumi, Nagashima, Kazuhide, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara, Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Walker, Richard, Yamashita, Katsuyuki, Yoneda, Shigekazu, Young, Edward, Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-Ichiro, Yoshikawa, Makoto, Tachibana, Shogo, Yurimoto, Hisayoshi, and Yin, Qing-Zhu

Abstract

Studies of material returned from Cb asteroid Ryugu have revealed considerable mineralogical and chemical heterogeneity, stemming primarily from brecciation and aqueous alteration. Isotopic anomalies could have also been affected by delivery of exogenous clasts and aqueous mobilization of soluble elements. Here, we show that isotopic anomalies for mildly soluble Cr are highly variable in Ryugu and CI chondrites, whereas those of Ti are relatively uniform. This variation in Cr isotope ratios is most likely due to physicochemical fractionation between 54Cr-rich presolar nanoparticles and Cr-bearing secondary minerals at the millimeter-scale in the bulk samples, likely due to extensive aqueous alteration in their parent bodies that occurred [Formula: see text] after Solar System birth. In contrast, Ti isotopes were marginally affected by this process. Our results show that isotopic heterogeneities in asteroids are not all nebular or accretionary in nature but can also reflect element redistribution by water.

Published
2023

4. Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Author

Bruin, Willem B, Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea L, Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo C, Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan AJP, Echevarria, Marco AN, Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D, Grazioplene, Rachael G, Gruner, Patricia, Guo, Joyce Y, Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-Shan R, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose M, Moreira, Pedro S, Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, Zorrilla, Jose C Pariente, Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan YC, Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair H, Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R, Evelyn Stewart, S, Szeszko, Philip R, Tang, Jinsong, Thomopoulos, Sophia I, Thorsen, Anders L, Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya M, Venkatasubramanian, Ganesan, Vetter, Nora C, Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke A, van Marle, Hein JF, van de Mortel, Laurens A, van der Straten, Anouk, van der Werf, Ysbrand D, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and van Wingen, Guido A

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical and Health Psychology, Clinical Sciences, Psychology, Machine Learning and Artificial Intelligence, Mental Illness, Serious Mental Illness, Brain Disorders, Anxiety Disorders, Mental Health, Good Health and Well Being, ENIGMA-OCD Working Group, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Correction to: Molecular Psychiatry, published online 2 May 2023 In this article Honami Arai, Irene Bollettini, Rosa Calvo Escalona, Ana Coelho, Federica Colombo, Leila Darwich, Martine Fontaine, Toshikazu Ikuta, Jonathan C. Ipser, Asier Juaneda-Seguí, Hitomi Kitagawa, Gerd Kvale, Mafalda Machado-Sousa, Astrid Morer, Takashi Nakamae, Jin Narumoto, Joseph O’Neill, Sho Okawa, Eva Real, Veit Roessner, Joao R. Sato, Cinto Segalàs, Roseli G. Shavitt, Dick J. Veltman, Kei Yamada were missing from the author list indexed under the ENIGMA-OCD Working Group. Additionally, there was an error regarding Tokiko Yoshida’s name, where the first name and last name were written in the wrong order. The original article has been corrected.

Published
2023

5. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium.

Author

Bruin, Willem, Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea, Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo, Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan, Echevarria, Marco, Eng, Goi, Ferreira, Sónia, Feusner, Jamie, Grazioplene, Rachael, Gruner, Patricia, Guo, Joyce, Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo, Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun, Lazaro, Luisa, Li, Chiang-Shan, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose, Moreira, Pedro, Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan, Nurmi, Erika, Zorrilla, Jose, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan, Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair, Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily, Evelyn Stewart, S, Szeszko, Philip, Tang, Jinsong, Thomopoulos, Sophia, Thorsen, Anders, Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya, Venkatasubramanian, Ganesan, Vetter, Nora, Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke, van Marle, Hein, van de Mortel, Laurens, van der Straten, Anouk, van der Werf, Ysbrand, Thompson, Paul, Stein, Dan, van den Heuvel, Odile, van Wingen, Guido, and Piacentini, John

Subjects
Humans, Connectome, Brain Mapping, Magnetic Resonance Imaging, Brain, Obsessive-Compulsive Disorder, Biomarkers, Neural Pathways
Abstract

Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1024 OCD patients and 1028 HC from 28 independent samples of the ENIGMA-OCD consortium. We assessed group differences in whole-brain functional connectivity at both the regional and network level, and investigated whether functional connectivity could serve as biomarker to identify patient status at the individual level using machine learning analysis. The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity (Cohens d: -0.27 to -0.13) and few hyper-connections, mainly with the thalamus (Cohens d: 0.19 to 0.22). Most hypo-connections were located within the sensorimotor network and no fronto-striatal abnormalities were found. Overall, classification performances were poor, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673, with better classification for medicated (AUC = 0.702) than unmedicated (AUC = 0.608) patients versus healthy controls. These findings provide partial support for existing pathophysiological models of OCD and highlight the important role of the sensorimotor network in OCD. However, resting-state connectivity does not so far provide an accurate biomarker for identifying patients at the individual level.

Published
2023

6. White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Author

Kim, Bo-Gyeom, Kim, Gakyung, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie, Anticevic, Alan, Arnold, Paul D., Balachander, Srinivas, Banaj, Nerisa, Bargalló, Nuria, Batistuzzo, Marcelo C., Benedetti, Francesco, Bertolín, Sara, Beucke, Jan Carl, Bollettini, Irene, Brem, Silvia, Brennan, Brian P., Buitelaar, Jan K., Calvo, Rosa, Castelo-Branco, Miguel, Cheng, Yuqi, Chhatkuli, Ritu Bhusal, Ciullo, Valentina, Coelho, Ana, Couto, Beatriz, Dallaspezia, Sara, Ely, Benjamin A., Ferreira, Sónia, Fontaine, Martine, Fouche, Jean-Paul, Grazioplene, Rachael, Gruner, Patricia, Hagen, Kristen, Hansen, Bjarne, Hanna, Gregory L., Hirano, Yoshiyuki, Höxter, Marcelo Q., Hough, Morgan, Hu, Hao, Huyser, Chaim, Ikuta, Toshikazu, Jahanshad, Neda, James, Anthony, Jaspers-Fayer, Fern, Kasprzak, Selina, Kathmann, Norbert, Kaufmann, Christian, Kim, Minah, Koch, Kathrin, Kvale, Gerd, Kwon, Jun Soo, Lazaro, Luisa, Lee, Junhee, Lochner, Christine, Lu, Jin, Manrique, Daniela Rodriguez, Martínez-Zalacaín, Ignacio, Masuda, Yoshitada, Matsumoto, Koji, Maziero, Maria Paula, Menchón, Jose M., Minuzzi, Luciano, Moreira, Pedro Silva, Morgado, Pedro, Narayanaswamy, Janardhanan C., Narumoto, Jin, Ortiz, Ana E., Ota, Junko, Pariente, Jose C., Perriello, Chris, Picó-Pérez, Maria, Pittenger, Christopher, Poletti, Sara, Real, Eva, Reddy, Y. C. Janardhan, van Rooij, Daan, Sakai, Yuki, Sato, João Ricardo, Segalas, Cinto, Shavitt, Roseli G., Shen, Zonglin, Shimizu, Eiji, Shivakumar, Venkataram, Soreni, Noam, Soriano-Mas, Carles, Sousa, Nuno, Sousa, Mafalda Machado, Spalletta, Gianfranco, Stern, Emily R., Stewart, S. Evelyn, Szeszko, Philip R., Thomas, Rajat, Thomopoulos, Sophia I., Vecchio, Daniela, Venkatasubramanian, Ganesan, Vriend, Chris, Walitza, Susanne, Wang, Zhen, Watanabe, Anri, Wolters, Lidewij, Xu, Jian, Yamada, Kei, Yun, Je-Yeon, Zarei, Mojtaba, Zhao, Qing, Zhu, Xi, Thompson, Paul M., Bruin, Willem B., van Wingen, Guido A., Piras, Federica, Piras, Fabrizio, Stein, Dan J., van den Heuvel, Odile A., Simpson, Helen Blair, Marsh, Rachel, and Cha, Jiook

Published
2024
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7. Abundant presolar grains and primordial organics preserved in carbon-rich exogenous clasts in asteroid Ryugu.

Author

Nguyen, Ann, Mane, Prajkta, Keller, Lindsay, Piani, Laurette, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel, Amari, Sachiko, Amelin, Yuri, Bajo, Ken-Ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard, Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew, Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko, Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary, Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor, Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko, Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander, Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin, Morita, Mayu, Motomura, Kazuko, Moynier, Frédéric, Nakai, Izumi, Nagashima, Kazuhide, Nesvorný, David, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Qin, Liping, Russell, Sara, Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard, Yamashita, Katsuyuki, Yokoyama, Tetsuya, Yoneda, Shigekazu, Young, Edward, Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-Ichiro, Yoshikawa, Makoto, Tachibana, Shogo, Yurimoto, Hisayoshi, and Yin, Qing-Zhu

Subjects
Carbon, Solar System, Meteoroids, Silicates
Abstract

Preliminary analyses of asteroid Ryugu samples show kinship to aqueously altered CI (Ivuna-type) chondrites, suggesting similar origins. We report identification of C-rich, particularly primitive clasts in Ryugu samples that contain preserved presolar silicate grains and exceptional abundances of presolar SiC and isotopically anomalous organic matter. The high presolar silicate abundance (104 ppm) indicates that the clast escaped extensive alteration. The 5 to 10 times higher abundances of presolar SiC (~235 ppm), N-rich organic matter, organics with N isotopic anomalies (1.2%), and organics with C isotopic anomalies (0.2%) in the primitive clasts compared to bulk Ryugu suggest that the clasts formed in a unique part of the protoplanetary disk enriched in presolar materials. These clasts likely represent previously unsampled outer solar system material that accreted onto Ryugu after aqueous alteration ceased, consistent with Ryugus rubble pile origin.

Published
2023

8. Presolar stardust in asteroid Ryugu

Author

Barosch, Jens, Nittler, Larry R., Wang, Jianhua, Alexander, Conel M. O'D., De Gregorio, Bradley T., Engrand, Cécile, Kebukawa, Yoko, Nagashima, Kazuhide, Stroud, Rhonda M., Yabuta, Hikaru, Abe, Yoshinari, Aléon, Jérôme, Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bejach, Laure, Bizzarro, Martin, Bonal, Lydie, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Cody, George D., Dartois, Emmanuel, Dauphas, Nicolas, Davis, Andrew M., Dazzi, Alexandre, Deniset-Besseau, Ariane, Di Rocco, Tommaso, Duprat, Jean, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hashiguchi, Minako, Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Ito, Motoo, Itoh, Shoichi, Kamide, Kanami, Kawasaki, Noriyuki, Kilcoyne, A. L. David, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Komatsu, Mutsumi, Krot, Alexander N., Liu, Ming-Chang, Martins, Zita, Masuda, Yuki, Mathurin, Jérémie, McKeegan, Kevin D., Montagnac, Gilles, Morita, Mayu, Mostefaoui, Smail, Motomura, Kazuko, Moynier, Frédéric, Nakai, Izumi, Nguyen, Ann N., Ohigashi, Takuji, Okumura, Taiga, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Quirico, Eric, Remusat, Laurent, Russell, Sara S., Sakamoto, Naoya, Sandford, Scott A., Schönbächler, Maria, Shigenaka, Miho, Suga, Hiroki, Tafla, Lauren, Takahashi, Yoshio, Takeichi, Yasuo, Tamenori, Yusuke, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Verdier-Paoletti, Maximilien, Wada, Sohei, Wadhwa, Meenakshi, Wakabayashi, Daisuke, Walker, Richard J., Yamashita, Katsuyuki, Yamashita, Shohei, Yin, Qing-Zhu, Yokoyama, Tetsuya, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nakazawa, Satoru, Nishimura, Masahiro, Okada, Tatsuaki, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yada, Toru, Yogata, Kasumi, Yoshikawa, Makoto, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Tachibana, Shogo, and Yurimoto, Hisayoshi

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

We have conducted a NanoSIMS-based search for presolar material in samples recently returned from C-type asteroid Ryugu as part of JAXA's Hayabusa2 mission. We report the detection of all major presolar grain types with O- and C-anomalous isotopic compositions typically identified in carbonaceous chondrite meteorites: 1 silicate, 1 oxide, 1 O-anomalous supernova grain of ambiguous phase, 38 SiC, and 16 carbonaceous grains. At least two of the carbonaceous grains are presolar graphites, whereas several grains with moderate C isotopic anomalies are probably organics. The presolar silicate was located in a clast with a less altered lithology than the typical extensively aqueously altered Ryugu matrix. The matrix-normalized presolar grain abundances in Ryugu are 4.8$^{+4.7}_{-2.6}$ ppm for O-anomalous grains, 25$^{+6}_{-5}$ ppm for SiC grains and 11$^{+5}_{-3}$ ppm for carbonaceous grains. Ryugu is isotopically and petrologically similar to carbonaceous Ivuna-type (CI) chondrites. To compare the in situ presolar grain abundances of Ryugu with CI chondrites, we also mapped Ivuna and Orgueil samples and found a total of SiC grains and 6 carbonaceous grains. No O-anomalous grains were detected. The matrix-normalized presolar grain abundances in the CI chondrites are similar to those in Ryugu: 23 $^{+7}_{-6}$ ppm SiC and 9.0$^{+5.3}_{-4.6}$ ppm carbonaceous grains. Thus, our results provide further evidence in support of the Ryugu-CI connection. They also reveal intriguing hints of small-scale heterogeneities in the Ryugu samples, such as locally distinct degrees of alteration that allowed the preservation of delicate presolar material., Comment: 12 pages, 3 figures, 2 tables. Published in ApJL

Published
2022
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9. Oxygen isotopes of anhydrous primary minerals show kinship between asteroid Ryugu and comet 81P/Wild2

Author

Kawasaki, Noriyuki, Nagashima, Kazuhide, Sakamoto, Naoya, Matsumoto, Toru, Bajo, Ken-ichi, Wada, Sohei, Igami, Yohei, Miyake, Akira, Noguchi, Takaaki, Yamamoto, Daiki, Russell, Sara S, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel M O’D, Amari, Sachiko, Amelin, Yuri, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W, Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M, Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K, Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R, Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R, Ishikawa, Akira, Ito, Motoo, Itoh, Shoichi, Kita, Noriko T, Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N, Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D, Morita, Mayu, Motomura, Kazuko, Moynier, Frédéric, Nakai, Izumi, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wadhwa, Meenakshi, Walker, Richard J, Yamashita, Katsuyuki, Yin, Qing-Zhu, Yokoyama, Tetsuya, Yoneda, Shigekazu, Young, Edward D, Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Subjects
Earth Sciences, Physical Sciences, Space Sciences, Geology, Prevention
Abstract

The extraterrestrial materials returned from asteroid (162173) Ryugu consist predominantly of low-temperature aqueously formed secondary minerals and are chemically and mineralogically similar to CI (Ivuna-type) carbonaceous chondrites. Here, we show that high-temperature anhydrous primary minerals in Ryugu and CI chondrites exhibit a bimodal distribution of oxygen isotopic compositions: 16O-rich (associated with refractory inclusions) and 16O-poor (associated with chondrules). Both the 16O-rich and 16O-poor minerals probably formed in the inner solar protoplanetary disk and were subsequently transported outward. The abundance ratios of the 16O-rich to 16O-poor minerals in Ryugu and CI chondrites are higher than in other carbonaceous chondrite groups but are similar to that of comet 81P/Wild2, suggesting that Ryugu and CI chondrites accreted in the outer Solar System closer to the accretion region of comets.

Published
2022

10. Pyrrhotites in asteroid 162173 Ryugu: Records of the initial changes on their surfaces with aqueous alteration

Author

Yui, Hiroharu, Urashima, Shu-hei, Onose, Morihiko, Morita, Mayu, Komatani, Shintaro, Nakai, Izumi, Abe, Yoshinari, Terada, Yasuko, Homma, Hisashi, Motomura, Kazuko, Ichida, Kiyohiro, Yokoyama, Tetsuya, Nagashima, Kazuhide, Aléon, Jérôme, M. O’D. Alexander, Conel, Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Hoppe, Peter, Huss, Gary R., Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Krot, Sasha, Liu, Ming-Chang, Masuda, Yuki, Moynier, Frédéric, Nguyen, Ann, Nittler, Larry, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Di Rocco, Tommaso, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Young, Edward D., Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Published
2024
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11. An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration

Author

van den Heuvel, Odile A, Boedhoe, Premika SW, Bertolin, Sara, Bruin, Willem B, Francks, Clyde, Ivanov, Iliyan, Jahanshad, Neda, Kong, Xiang‐Zhen, Kwon, Jun Soo, O'Neill, Joseph, Paus, Tomas, Patel, Yash, Piras, Fabrizio, Schmaal, Lianne, Soriano‐Mas, Carles, Spalletta, Gianfranco, van Wingen, Guido A, Yun, Je‐Yeon, Vriend, Chris, Simpson, H Blair, van Rooij, Daan, Hoexter, Marcelo Q, Hoogman, Martine, Buitelaar, Jan K, Arnold, Paul, Beucke, Jan C, Benedetti, Francesco, Bollettini, Irene, Bose, Anushree, Brennan, Brian P, De Nadai, Alessandro S, Fitzgerald, Kate, Gruner, Patricia, Grünblatt, Edna, Hirano, Yoshiyuki, Huyser, Chaim, James, Anthony, Koch, Kathrin, Kvale, Gerd, Lazaro, Luisa, Lochner, Christine, Marsh, Rachel, Mataix‐Cols, David, Morgado, Pedro, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika, Pittenger, Christopher, Reddy, YC Janardhan, Sato, João R, Soreni, Noam, Stewart, S Evelyn, Taylor, Stephan F, Tolin, David, Thomopoulos, Sophia I, Veltman, Dick J, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Thompson, Paul M, Stein, Dan J, Abe, Yoshinari, Alonso, Pino, Assogna, Francesca, Banaj, Nerisa, Batistuzzo, Marcelo C, Brem, Silvia, Ciullo, Valentina, Feusner, Jamie, Martínez‐Zalacaín, Ignacio, Menchón, José M, Miguel, Euripedes C, Piacentini, John, Piras, Federica, Sakai, Yuki, Wolters, Lidewij, and Yamada, Kei

Subjects
Biological Psychology, Psychology, Brain Disorders, Clinical Research, Serious Mental Illness, Pediatric, Neurosciences, Mental Health, Mental health, Neurological, Cerebral Cortex, Humans, Machine Learning, Multicenter Studies as Topic, Neuroimaging, Obsessive-Compulsive Disorder, cortical thickness, ENIGMA, mega-analysis, meta-analysis, MRI, obsessive-compulsive disorder, surface area, volume, ENIGMA-OCD working group, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls. Initial work has focused on studies of cortical thickness and subcortical volumes, structural connectivity, and brain lateralization in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders. Additional work is ongoing, employing machine learning techniques. Findings to date have contributed to the development of neurobiological models of OCD, have provided an important model of global scientific collaboration, and have had a number of clinical implications. Importantly, our work has shed new light on questions about whether structural and functional alterations found in OCD reflect neurodevelopmental changes, effects of the disease process, or medication impacts. We conclude with a summary of ongoing work by ENIGMA-OCD, and a consideration of future directions for neuroimaging research on OCD within and beyond ENIGMA.

Published
2022

12. Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Author

Kim, Bo-Gyeom, Kim, Gakyung, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie, Anticevic, Alan, Arnold, Paul D., Balachander, Srinivas, Banaj, Nerisa, Bargalló, Nuria, Batistuzzo, Marcelo C., Benedetti, Francesco, Bertolín, Sara, Beucke, Jan Carl, Bollettini, Irene, Brem, Silvia, Brennan, Brian P., Buitelaar, Jan K., Calvo, Rosa, Castelo-Branco, Miguel, Cheng, Yuqi, Chhatkuli, Ritu Bhusal, Ciullo, Valentina, Coelho, Ana, Couto, Beatriz, Dallaspezia, Sara, Ely, Benjamin A., Ferreira, Sónia, Fontaine, Martine, Fouche, Jean-Paul, Grazioplene, Rachael, Gruner, Patricia, Hagen, Kristen, Hansen, Bjarne, Hanna, Gregory L., Hirano, Yoshiyuki, Höxter, Marcelo Q., Hough, Morgan, Hu, Hao, Huyser, Chaim, Ikuta, Toshikazu, Jahanshad, Neda, James, Anthony, Jaspers-Fayer, Fern, Kasprzak, Selina, Kathmann, Norbert, Kaufmann, Christian, Kim, Minah, Koch, Kathrin, Kvale, Gerd, Kwon, Jun Soo, Lazaro, Luisa, Lee, Junhee, Lochner, Christine, Lu, Jin, Manrique, Daniela Rodriguez, Martínez-Zalacaín, Ignacio, Masuda, Yoshitada, Matsumoto, Koji, Maziero, Maria Paula, Menchón, Jose M., Minuzzi, Luciano, Moreira, Pedro Silva, Morgado, Pedro, Narayanaswamy, Janardhanan C., Narumoto, Jin, Ortiz, Ana E., Ota, Junko, Pariente, Jose C., Perriello, Chris, Picó-Pérez, Maria, Pittenger, Christopher, Poletti, Sara, Real, Eva, Reddy, Y. C. Janardhan, van Rooij, Daan, Sakai, Yuki, Sato, João Ricardo, Segalas, Cinto, Shavitt, Roseli G., Shen, Zonglin, Shimizu, Eiji, Shivakumar, Venkataram, Soreni, Noam, Soriano-Mas, Carles, Sousa, Nuno, Sousa, Mafalda Machado, Spalletta, Gianfranco, Stern, Emily R., Stewart, S. Evelyn, Szeszko, Philip R., Thomas, Rajat, Thomopoulos, Sophia I., Vecchio, Daniela, Venkatasubramanian, Ganesan, Vriend, Chris, Walitza, Susanne, Wang, Zhen, Watanabe, Anri, Wolters, Lidewij, Xu, Jian, Yamada, Kei, Yun, Je-Yeon, Zarei, Mojtaba, Zhao, Qing, Zhu, Xi, Thompson, Paul M., Bruin, Willem B., van Wingen, Guido A., Piras, Federica, Piras, Fabrizio, Stein, Dan J., van den Heuvel, Odile A., Simpson, Helen Blair, Marsh, Rachel, and Cha, Jiook

Published
2024
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13. Pervasive aqueous alteration in the early Solar System revealed by potassium isotopic variations in Ryugu samples and carbonaceous chondrites

Author

Hu, Yan, Moynier, Frédéric, Dai, Wei, Paquet, Marine, Yokoyama, Tetsuya, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel M. O'D., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Koki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, Morita, Mayu, Motomura, Kazuko, Nakai, Izumi, Nagashima, Kazuhide, Nesvorný, David, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Published
2024
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14. Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

Author

Paquet, Marine, Moynier, Frederic, Yokoyama, Tetsuya, Dai, Wei, Hu, Yan, Abe, Yoshinari, Aléon, Jérôme, O’D. Alexander, Conel M., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Ito, Motoo, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Nakai, Izumi, Nagashima, Kazuhide, Nesvorný, David, Nguyen, Ann N., Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Published
2023
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15. Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.

Author

Bruin, Willem B, Taylor, Luke, Thomas, Rajat M, Shock, Jonathan P, Zhutovsky, Paul, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Assogna, Francesca, Benedetti, Francesco, Beucke, Jan C, Boedhoe, Premika SW, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Brennan, Brian P, Buitelaar, Jan K, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Dallaspezia, Sara, Denys, Damiaan, Ely, Benjamin A, Feusner, Jamie D, Fitzgerald, Kate D, Fouche, Jean-Paul, Fridgeirsson, Egill A, Gruner, Patricia, Gürsel, Deniz A, Hauser, Tobias U, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Ivanov, Iliyan, James, Anthony, Jaspers-Fayer, Fern, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kuno, Masaru, Kvale, Gerd, Kwon, Jun Soo, Liu, Yanni, Lochner, Christine, Lázaro, Luisa, Marques, Paulo, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Moreira, Pedro S, Morer, Astrid, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, O'Neill, Joseph, Pariente, Jose C, Perriello, Chris, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Rus-Oswald, Oana G, Sakai, Yuki, Sato, João R, Schmaal, Lianne, Shimizu, Eiji, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stern, Emily R, Stevens, Michael C, Stewart, S Evelyn, Szeszko, Philip R, Tolin, David F, Venkatasubramanian, Ganesan, Wang, Zhen, Yun, Je-Yeon, van Rooij, Daan, ENIGMA-OCD Working Group, Thompson, Paul M, van den Heuvel, Odile A, Stein, Dan J, and van Wingen, Guido A

Subjects
ENIGMA-OCD Working Group, Clinical Sciences, Public Health and Health Services, Psychology
Abstract

No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.

Published
2020

16. Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups

Author

Boedhoe, Premika SW, van Rooij, Daan, Hoogman, Martine, Twisk, Jos WR, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anikin, Anatoly, Anticevic, Alan, Arango, Celso, Arnold, Paul D, Asherson, Philip, Assogna, Francesca, Auzias, Guillaume, Banaschewski, Tobias, Baranov, Alexander, Batistuzzo, Marcelo C, Baumeister, Sarah, Baur-Streubel, Ramona, Behrmann, Marlene, Bellgrove, Mark A, Benedetti, Francesco, Beucke, Jan C, Biederman, Joseph, Bollettini, Irene, Bose, Anushree, Bralten, Janita, Bramati, Ivanei E, Brandeis, Daniel, Brem, Silvia, Brennan, Brian P, Busatto, Geraldo F, Calderoni, Sara, Calvo, Anna, Calvo, Rosa, Castellanos, Francisco X, Cercignani, Mara, Chaim-Avancini, Tiffany M, Chantiluke, Kaylita C, Cheng, Yuqi, Cho, Kang Ik K, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Cubillo, Ana I, Dale, Anders M, Dallaspezia, Sara, Daly, Eileen, Denys, Damiaan, Deruelle, Christine, Di Martino, Adriana, Dinstein, Ilan, Doyle, Alysa E, Durston, Sarah, Earl, Eric A, Ecker, Christine, Ehrlich, Stefan, Ely, Benjamin A, Epstein, Jeffrey N, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas J, Faraone, Stephen V, Fedor, Jennifer, Feng, Xin, Feusner, Jamie D, Fitzgerald, Jackie, Fitzgerald, Kate D, Fouche, Jean-Paul, Freitag, Christine M, Fridgeirsson, Egill A, Frodl, Thomas, Gabel, Matt C, Gallagher, Louise, Gogberashvili, Tinatin, Gori, Ilaria, Gruner, Patricia, Gürsel, Deniz A, Haar, Shlomi, Haavik, Jan, Hall, Geoffrey B, Harrison, Neil A, Hartman, Catharina A, Heslenfeld, Dirk J, Hirano, Yoshiyuki, Hoekstra, Pieter J, Hoexter, Marcelo Q, Hohmann, Sarah, Høvik, Marie F, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, Jalbrzikowski, Maria, James, Anthony, Janssen, Joost, Jaspers-Fayer, Fern, Jernigan, Terry L, Kapilushniy, Dmitry, and Kardatzki, Bernd

Subjects
Attention Deficit Hyperactivity Disorder (ADHD), Behavioral and Social Science, Clinical Research, Mental Health, Neurosciences, Pediatric, Autism, Intellectual and Developmental Disabilities (IDD), Brain Disorders, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Neurological, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Cerebrum, Child, Female, Human Development, Humans, Male, Neuroimaging, Obsessive-Compulsive Disorder, Organ Size, Psychopathology, Research Report, Systems Analysis, ENIGMA ADHD working group, ENIGMA ASD working group, ENIGMA OCD working group, Attention Deficit Hyperactivity Disorder, ENIGMA, Structural MRI, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveAttention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these disorders using structural brain imaging data from ENIGMA consortium data.MethodsStructural T1-weighted whole-brain MRI data from healthy control subjects (N=5,827) and from patients with ADHD (N=2,271), ASD (N=1,777), and OCD (N=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. The authors examined subcortical volume, cortical thickness, and cortical surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults, using linear mixed-effects models adjusting for age, sex, and site (and intracranial volume for subcortical and surface area measures).ResultsNo shared differences were found among all three disorders, and shared differences between any two disorders did not survive correction for multiple comparisons. Children with ADHD compared with those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller intracranial volume than control subjects and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared with adult control subjects and other clinical groups. No OCD-specific differences were observed across different age groups and surface area differences among all disorders in childhood and adulthood.ConclusionsThe study findings suggest robust but subtle differences across different age groups among ADHD, ASD, and OCD. ADHD-specific intracranial volume and hippocampal differences in children and adolescents, and ASD-specific cortical thickness differences in the frontal cortex in adults, support previous work emphasizing structural brain differences in these disorders.

Published
2020

17. Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

Author

Kong, Xiang-Zhen, Boedhoe, Premika SW, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Arnold, Paul D, Assogna, Francesca, Baker, Justin T, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Brennan, Brian P, Buitelaar, Jan, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Dallaspezia, Sara, Denys, Damiaan, Ely, Benjamin A, Feusner, Jamie, Fitzgerald, Kate D, Fouche, Jean-Paul, Fridgeirsson, Egill A, Glahn, David C, Gruner, Patricia, Gürsel, Deniz A, Hauser, Tobias U, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, James, Anthony, Jaspers-Fayer, Fern, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kuno, Masaru, Kvale, Gerd, Kwon, Jun Soo, Lazaro, Luisa, Liu, Yanni, Lochner, Christine, Marques, Paulo, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Medland, Sarah E, Menchón, José M, Minuzzi, Luciano, Moreira, Pedro S, Morer, Astrid, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, O'Neill, Joseph, Pariente, Jose C, Perriello, Chris, Piacentini, John, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, YC Janardhan, Rus-Oswald, Oana Georgiana, Sakai, Yuki, Sato, Joao R, Schmaal, Lianne, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stern, Emily R, Stevens, Michael C, Stewart, S Evelyn, Szeszko, Philip R, Tolin, David F, Tsuchiyagaito, Aki, van Rooij, Daan, van Wingen, Guido A, Venkatasubramanian, Ganesan, Wang, Zhen, Yun, Je-Yeon, Group, ENIGMA OCD Working, Anticevic, Alan, Banaj, Nerisa, and Bargalló, Nuria

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Serious Mental Illness, Mental Health, Neurosciences, Brain Disorders, Clinical Research, Anxiety Disorders, Neurological, Mental health, Adult, Brain, Brain Mapping, Child, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Obsessive-Compulsive Disorder, Thalamus, Brain asymmetry, Laterality, Mega-analysis, Obsessive-compulsive disorder, Pallidum, ENIGMA OCD Working Group, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological sciences, Biomedical and clinical sciences
Abstract

BackgroundLateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD.MethodsWe studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status.ResultsIn the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets.ConclusionsThe results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

Published
2020

18. Corrigendum

Author

Yun, Je-Yeon, Boedhoe, Premika SW, Vriend, Chris, Jahanshad, Neda, Abe, Yoshinari, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Cheng, Yuqi, Cho, Kang Ik K, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie D, Fouche, Jean-Paul, Gimenez, Monica, Gruner, Patricia, Hibar, Derrek P, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Ikari, Keisuke, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Lazaro, Luisa, Lochner, Christine, Marques, Paulo, Marsh, Rachel, Martinez-Zalacain, Ignacio, Mataix-Cols, David, Menchon, Jose M, Minuzzi, Luciano, Morgado, Pedro, Moreira, Pedro, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, O'Neill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Sato, Joao R, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael C, Szeszko, Philip R, Tolin, David F, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, van Wingen, Guido A, Xu, Jian, Xu, Xiufeng, Zhao, Qing, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and Kwon, Jun Soo

Subjects
Biomedical and Clinical Sciences, Health Sciences, Psychology, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Published
2020

19. Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium

Author

Yun, Je-Yeon, Boedhoe, Premika SW, Vriend, Chris, Jahanshad, Neda, Abe, Yoshinari, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Cheng, Yuqi, Cho, Kang Ik K, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie D, Fouche, Jean-Paul, Giménez, Mònica, Gruner, Patricia, Hibar, Derrek P, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Ikari, Keisuke, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Lazaro, Luisa, Lochner, Christine, Marques, Paulo, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morgado, Pedro, Moreira, Pedro, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, O’Neill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Sato, Joao R, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael C, Szeszko, Philip R, Tolin, David F, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, van Wingen, Guido A, Xu, Jian, Xu, Xiufeng, Zhao, Qing, van den Heuvel, Odile3 A, Stein, Dan J, Thompson, Paul M, Ik, Kang, and Cho, K

Subjects
Mental Health, Brain Disorders, Serious Mental Illness, Clinical Research, Neurosciences, Neurological, Mental health, Adult, Brain, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Obsessive-Compulsive Disorder, brain structural covariance network, graph theory, obsessive-compulsive disorder, pharmacotherapy, illness duration, ENIGMA-OCD working group, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P

Published
2020

20. An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

Author

Boedhoe, Premika SW, Heymans, Martijn W, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie D, Fitzgerald, Kate D, Fouche, Jean-Paul, Fridgeirsson, Egill A, Gruner, Patricia, Hanna, Gregory L, Hibar, Derrek P, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kwon, Jun Soo, Lazaro, Luisa, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morer, Astrid, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nishida, Seiji, Nurmi, Erika L, O'Neill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Reess, Tim J, Sakai, Yuki, Sato, Joao R, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael C, Szeszko, Philip R, Tolin, David F, van Wingen, Guido A, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Yun, Je-Yeon, Working-Group, ENIGMA-OCD, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and Twisk, Jos WR

Subjects
Biomedical and Clinical Sciences, Information and Computing Sciences, Neurosciences, Applied Computing, Machine Learning, neuroimaging, MRI, IPD meta-analysis, mega-analysis, linear mixed-effect models, ENIGMA-OCD Working-Group, Cognitive Sciences, Applied computing, Machine learning
Abstract

Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses. Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods. Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models. Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data.

Published
2019

22. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder

Author

Weeland, Cees J., Kasprzak, Selina, de Joode, Niels T., Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H., Anticevic, Alan, Arnold, Paul D., Balachander, Srinivas, Banaj, Nerisa, Bargallo, Nuria, Batistuzzo, Marcelo C., Benedetti, Francesco, Beucke, Jan C., Bollettini, Irene, Brecke, Vilde, Brem, Silvia, Cappi, Carolina, Cheng, Yuqi, Cho, Kang Ik K., Costa, Daniel L. C., Dallaspezia, Sara, Denys, Damiaan, Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D., Fontaine, Martine, Fouche, Jean-Paul, Grazioplene, Rachael G., Gruner, Patricia, He, Mengxin, Hirano, Yoshiyuki, Hoexter, Marcelo Q., Huyser, Chaim, Hu, Hao, Jaspers-Fayer, Fern, Kathmann, Norbert, Kaufmann, Christian, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-shan R., Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, Jose M., Minnuzi, Luciano, Moreira, Pedro Silva, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Narayanaswamy, Janardhanan C., Nurmi, Erika L., Ortiz, Ana E., Pariente, Jose C., Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Y. C. Janardhan, Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Helen Blair, Soreni, Noam, Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R., Stevens, Michael C., Stewart, S. Evelyn, Szeszko, Philip R., Takahashi, Jumpei, Tanamatis, Tais, Tang, Jinsong, Thorsen, Anders Lillevik, Tolin, David, van der Werf, Ysbrand D., van Marle, Hein, van Wingen, Guido A., Vecchio, Daniela, Venkatasubramanian, G., Walitza, Susanne, Wang, Jicai, Wang, Zhen, Watanabe, Anri, Wolters, Lidewij H., Xu, Xiufeng, Yun, Je-Yeon, Zhao, Qing, White, Tonya, Thompson, Paul M., Stein, Dan J., van den Heuvel, Odile A., and Vriend, Chris

Published
2022
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23. A neural marker of obsessive-compulsive disorder from whole-brain functional connectivity

Author

Takagi, Yu, Sakai, Yuki, Lisi, Giuseppe, Yahata, Noriaki, Abe, Yoshinari, Nishida, Seiji, Nakamae, Takashi, Morimoto, Jun, Kawato, Mitsuo, Narumoto, Jin, and Tanaka, Saori C.

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2-3 percent. Recently, brain activity in the resting state is gathering attention as a new means of exploring altered functional connectivity in psychiatric disorders. Although previous resting-state functional magnetic resonance imaging studies investigated neurobiological abnormalities of patients with OCD, there are concerns that should be addressed. One concern is the validity of the hypothesis employed. Most studies used seed-based analysis of the fronto-striatal circuit, despite the potential for abnormalities in other regions. A hypothesis-free study is a promising approach in such a case, while it requires researchers to handle a dataset with large dimensions. Another concern is the reliability of biomarkers derived from a single dataset, which may be influenced by cohort-specific features. Here, by employing a recently developed machine-learning algorithm to avoid these concerns, we identified the first OCD biomarker that is generalized to an external dataset. We also demonstrated that the functional connectivities that contributed to the classification were widely distributed rather than locally constrained. Our generalizable classifier has the potential not only to deepen our understanding of the abnormal neural substrates of OCD but also to find use in clinical applications., Comment: 47 pages, 3 figures

Published
2017
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24. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group

Author

Boedhoe, Premika SW, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie D, Fitzgerald, Kate D, Fouche, Jean-Paul, Fridgeirsson, Egill A, Gruner, Patricia, Hanna, Gregory L, Hibar, Derrek P, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kwon, Jun Soo, Lazaro, Luisa, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morer, Astrid, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nishida, Seiji, Nurmi, Erika, O’Neill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Reess, Tim J, Sakai, Yuki, Sato, Joao R, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael C, Szeszko, Philip R, Tolin, David F, van Wingen, Guido A, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Yun, Je-Yeon, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, Bargalló, Nuria, Brandeis, Daniel, Buimer, Elizabeth, Busatto, Geraldo F, de Vries, Froukje E, de Wit, Stella J, Drechsler, Renate, and Falini, Andrea

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Pediatric, Neurosciences, Mental Health, Serious Mental Illness, Brain Disorders, Neurological, Mental health, Adolescent, Adult, Age of Onset, Cerebral Cortex, Child, Frontal Lobe, Humans, Magnetic Resonance Imaging, Obsessive-Compulsive Disorder, Parietal Lobe, Reference Values, Temporal Lobe, Young Adult, ENIGMA-OCD Working Group, ENIGMA OCD Working Group, Cortical Thickness, FreeSurfer, MRI, Surface Area, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

ObjectiveBrain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses comprising the largest study of cortical morphometry in OCD ever undertaken.MethodT1-weighted MRI scans of 1,905 OCD patients and 1,760 healthy controls from 27 sites worldwide were processed locally using FreeSurfer to assess cortical thickness and surface area. Effect sizes for differences between patients and controls, and associations with clinical characteristics, were calculated using linear regression models controlling for age, sex, site, and intracranial volume.ResultsIn adult OCD patients versus controls, we found a significantly lower surface area for the transverse temporal cortex and a thinner inferior parietal cortex. Medicated adult OCD patients also showed thinner cortices throughout the brain. In pediatric OCD patients compared with controls, we found significantly thinner inferior and superior parietal cortices, but none of the regions analyzed showed significant differences in surface area. However, medicated pediatric OCD patients had lower surface area in frontal regions. Cohen's d effect sizes varied from -0.10 to -0.33.ConclusionsThe parietal cortex was consistently implicated in both adults and children with OCD. More widespread cortical thickness abnormalities were found in medicated adult OCD patients, and more pronounced surface area deficits (mainly in frontal regions) were found in medicated pediatric OCD patients. These cortical measures represent distinct morphological features and may be differentially affected during different stages of development and illness, and possibly moderated by disease profile and medication.

Published
2018

25. An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group.

Author

Boedhoe, Premika, Heymans, Martijn, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie, Anticevic, Alan, Arnold, Paul, Batistuzzo, Marcelo, Benedetti, Francesco, Beucke, Jan, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Calvo, Rosa, Cheng, Yuqi, Cho, Kang, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie, Fitzgerald, Kate, Fouche, Jean-Paul, Fridgeirsson, Egill, Gruner, Patricia, Hanna, Gregory, Hibar, Derrek, Hoexter, Marcelo, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kwon, Jun, Lazaro, Luisa, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José, Minuzzi, Luciano, Morer, Astrid, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan, Nishida, Seiji, Nurmi, Erika, Oneill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, Y, Reess, Tim, Sakai, Yuki, Sato, Joao, Simpson, H, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael, Szeszko, Philip, Tolin, David, van Wingen, Guido, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Yun, Je-Yeon, Thompson, Paul, Stein, Dan, van den Heuvel, Odile, and Twisk, Jos

Subjects
IPD meta-analysis, MRI, linear mixed-effect models, mega-analysis, neuroimaging
Abstract

Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses. Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods. Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models. Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data.

Published
2018

27. Disequilibrium oxygen isotope distribution among aqueously altered minerals in Ryugu asteroid returned samples

Author

Kita, Noriko T., primary, Kitajima, Kouki, additional, Nagashima, Kazuhide, additional, Kawasaki, Noriyuki, additional, Sakamoto, Naoya, additional, Fujiya, Wataru, additional, Abe, Yoshinari, additional, Aléon, Jérôme, additional, Alexander, Conel M. O'D., additional, Amari, Sachiko, additional, Amelin, Yuri, additional, Bajo, Ken‐ichi, additional, Bizzarro, Martin, additional, Bouvier, Audrey, additional, Carlson, Richard W., additional, Chaussidon, Marc, additional, Choi, Byeon‐Gak, additional, Dauphas, Nicolas, additional, Davis, Andrew M., additional, Di Rocco, Tommaso, additional, Fukai, Ryota, additional, Gautam, Ikshu, additional, Haba, Makiko K., additional, Hibiya, Yuki, additional, Hidaka, Hiroshi, additional, Homma, Hisashi, additional, Hoppe, Peter, additional, Huss, Gary R., additional, Ichida, Kiyohiro, additional, Iizuka, Tsuyoshi, additional, Ireland, Trevor R., additional, Ishikawa, Akira, additional, Itoh, Shoichi, additional, Kleine, Thorsten, additional, Komatani, Shintaro, additional, Krot, Alexander N., additional, Liu, Ming‐Chang, additional, Masuda, Yuki, additional, McKeegan, Kevin D., additional, Morita, Mayu, additional, Motomura, Kazuko, additional, Moynier, Frédéric, additional, Nakai, Izumi, additional, Nguyen, Ann, additional, Nittler, Larry, additional, Onose, Morihiko, additional, Pack, Andreas, additional, Park, Changkun, additional, Piani, Laurette, additional, Qin, Liping, additional, Russell, Sara S., additional, Schönbächler, Maria, additional, Tafla, Lauren, additional, Tang, Haolan, additional, Terada, Kentaro, additional, Terada, Yasuko, additional, Usui, Tomohiro, additional, Wada, Sohei, additional, Wadhwa, Meenakshi, additional, Walker, Richard J., additional, Yamashita, Katsuyuki, additional, Yin, Qing‐Zhu, additional, Yokoyama, Tetsuya, additional, Yoneda, Shigekazu, additional, Young, Edward D., additional, Yui, Hiroharu, additional, Zhang, Ai‐Cheng, additional, Nakamura, Tomoki, additional, Naraoka, Hiroshi, additional, Noguchi, Takaaki, additional, Okazaki, Ryuji, additional, Sakamoto, Kanako, additional, Yabuta, Hikaru, additional, Abe, Masanao, additional, Miyazaki, Akiko, additional, Nakato, Aiko, additional, Nishimura, Masahiro, additional, Okada, Tatsuaki, additional, Yada, Toru, additional, Yogata, Kasumi, additional, Nakazawa, Satoru, additional, Saiki, Takanao, additional, Tanaka, Satoshi, additional, Terui, Fuyuto, additional, Tsuda, Yuichi, additional, Watanabe, Sei‐ichiro, additional, Yoshikawa, Makoto, additional, Tachibana, Shogo, additional, and Yurimoto, Hisayoshi, additional

Published
2024
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29. Author Correction: Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

Author

Paquet, Marine, Moynier, Frederic, Yokoyama, Tetsuya, Dai, Wei, Hu, Yan, Abe, Yoshinari, Aléon, Jérôme, O’D. Alexander, Conel M., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Ito, Motoo, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Nakai, Izumi, Nagashima, Kazuhide, Nesvorný, David, Nguyen, Ann N., Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Published
2023
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30. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

Author

Guadalupe, Tulio, Mathias, Samuel R, vanErp, Theo GM, Whelan, Christopher D, Zwiers, Marcel P, Abe, Yoshinari, Abramovic, Lucija, Agartz, Ingrid, Andreassen, Ole A, Arias-Vásquez, Alejandro, Aribisala, Benjamin S, Armstrong, Nicola J, Arolt, Volker, Artiges, Eric, Ayesa-Arriola, Rosa, Baboyan, Vatche G, Banaschewski, Tobias, Barker, Gareth, Bastin, Mark E, Baune, Bernhard T, Blangero, John, Bokde, Arun LW, Boedhoe, Premika SW, Bose, Anushree, Brem, Silvia, Brodaty, Henry, Bromberg, Uli, Brooks, Samantha, Büchel, Christian, Buitelaar, Jan, Calhoun, Vince D, Cannon, Dara M, Cattrell, Anna, Cheng, Yuqi, Conrod, Patricia J, Conzelmann, Annette, Corvin, Aiden, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dannlowski, Udo, de Zubicaray, Greig I, de Zwarte, Sonja MC, Deary, Ian J, Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Dørum, Erlend S, Ehrlich, Stefan, Espeseth, Thomas, Fernández, Guillén, Flor, Herta, Fouche, Jean-Paul, Frouin, Vincent, Fukunaga, Masaki, Gallinat, Jürgen, Garavan, Hugh, Gill, Michael, Suarez, Andrea Gonzalez, Gowland, Penny, Grabe, Hans J, Grotegerd, Dominik, Gruber, Oliver, Hagenaars, Saskia, Hashimoto, Ryota, Hauser, Tobias U, Heinz, Andreas, Hibar, Derrek P, Hoekstra, Pieter J, Hoogman, Martine, Howells, Fleur M, Hu, Hao, Hulshoff Pol, Hilleke E, Huyser, Chaim, Ittermann, Bernd, Jahanshad, Neda, Jönsson, Erik G, Jurk, Sarah, Kahn, Rene S, Kelly, Sinead, Kraemer, Bernd, Kugel, Harald, Kwon, Jun Soo, Lemaitre, Herve, Lesch, Klaus-Peter, Lochner, Christine, Luciano, Michelle, Marquand, Andre F, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Martinot, Jean-Luc, Mataix-Cols, David, Mather, Karen, McDonald, Colm, McMahon, Katie L, Medland, Sarah E, Menchón, José M, Morris, Derek W, Mothersill, Omar, Maniega, Susana Munoz, and Mwangi, Benson

Subjects
Brain, Humans, Magnetic Resonance Imaging, Organ Size, Aging, Sex Characteristics, Quantitative Trait, Heritable, Adolescent, Adult, Aged, Middle Aged, Female, Male, Functional Laterality, Meta-Analysis as Topic, Young Adult, Age, Enigma, Handedness, Heritability, Meta-analysis, Sex, Subcortical brain asymmetry, Quantitative Trait, Heritable, Medical and Health Sciences, Psychology and Cognitive Sciences, Experimental Psychology
Abstract

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

Published
2017

31. White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Author

Kim, Bo-Gyeom; https://orcid.org/0000-0003-2685-877X, Kim, Gakyung, Abe, Yoshinari; https://orcid.org/0000-0001-8348-0801, Alonso, Pino; https://orcid.org/0000-0002-5779-9111, Ameis, Stephanie; https://orcid.org/0000-0002-7282-6077, Anticevic, Alan; https://orcid.org/0000-0002-4324-0536, Arnold, Paul D; https://orcid.org/0000-0003-2496-4624, Balachander, Srinivas, Banaj, Nerisa; https://orcid.org/0000-0002-6317-8549, Bargalló, Nuria, Batistuzzo, Marcelo C; https://orcid.org/0000-0003-1347-8241, Benedetti, Francesco; https://orcid.org/0000-0003-4949-856X, Bertolín, Sara; https://orcid.org/0000-0003-1468-7862, Beucke, Jan Carl, Bollettini, Irene; https://orcid.org/0000-0003-3666-3538, Brem, Silvia; https://orcid.org/0000-0002-8031-1305, Brennan, Brian P; https://orcid.org/0000-0001-5468-6552, Buitelaar, Jan K; https://orcid.org/0000-0001-8288-7757, Calvo, Rosa; https://orcid.org/0000-0001-9572-4228, Castelo-Branco, Miguel, Cheng, Yuqi, Chhatkuli, Ritu Bhusal, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Coelho, Ana, Couto, Beatriz, Dallaspezia, Sara, Ely, Benjamin A; https://orcid.org/0000-0002-3019-0090, Ferreira, Sónia, Fontaine, Martine, Fouche, Jean-Paul, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, et al, Kim, Bo-Gyeom; https://orcid.org/0000-0003-2685-877X, Kim, Gakyung, Abe, Yoshinari; https://orcid.org/0000-0001-8348-0801, Alonso, Pino; https://orcid.org/0000-0002-5779-9111, Ameis, Stephanie; https://orcid.org/0000-0002-7282-6077, Anticevic, Alan; https://orcid.org/0000-0002-4324-0536, Arnold, Paul D; https://orcid.org/0000-0003-2496-4624, Balachander, Srinivas, Banaj, Nerisa; https://orcid.org/0000-0002-6317-8549, Bargalló, Nuria, Batistuzzo, Marcelo C; https://orcid.org/0000-0003-1347-8241, Benedetti, Francesco; https://orcid.org/0000-0003-4949-856X, Bertolín, Sara; https://orcid.org/0000-0003-1468-7862, Beucke, Jan Carl, Bollettini, Irene; https://orcid.org/0000-0003-3666-3538, Brem, Silvia; https://orcid.org/0000-0002-8031-1305, Brennan, Brian P; https://orcid.org/0000-0001-5468-6552, Buitelaar, Jan K; https://orcid.org/0000-0001-8288-7757, Calvo, Rosa; https://orcid.org/0000-0001-9572-4228, Castelo-Branco, Miguel, Cheng, Yuqi, Chhatkuli, Ritu Bhusal, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Coelho, Ana, Couto, Beatriz, Dallaspezia, Sara, Ely, Benjamin A; https://orcid.org/0000-0002-3019-0090, Ferreira, Sónia, Fontaine, Martine, Fouche, Jean-Paul, Walitza, Susanne; https://orcid.org/0000-0002-8161-8683, and et al

Abstract

White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group. We used an automatic machine learning pipeline (with feature engineering and selection, and model optimization) and examined the cross-site generalizability of the OCD classification models using leave-one-site-out cross-validation. Our models showed low-to-moderate accuracy in classifying (1) “OCD vs. healthy controls” (Adults, receiver operator characteristic-area under the curve = 57.19 ± 3.47 in the replication set; Children, 59.8 ± 7.39), (2) “unmedicated OCD vs. healthy controls” (Adults, 62.67 ± 3.84; Children, 48.51 ± 10.14), and (3) “medicated OCD vs. unmedicated OCD” (Adults, 76.72 ± 3.97; Children, 72.45 ± 8.87). There was significant site variability in model performance (cross-validated ROC AUC ranges 51.6–79.1 in adults; 35.9–63.2 in children). Machine learning interpretation showed that diffusivity measures of the corpus callosum, internal capsule, and posterior thalamic radiation contributed to the classification of OCD from HC. The classification performance appeared greater than the model trained on grey matter morphometry in the prior ENIGMA OCD study (our study includes subsamples from the morphometry study). Taken together, this study points to the meaningful multivariate patterns of white matter features relevant to the neurobiology of OCD, but with low-to-moderate classification accuracy. The OCD classification

Published
2024

32. Analysis of Cation Composition in Dolomites on the Intact Particles Sampled from Asteroid Ryugu

Author

Morita, Mayu, Yui, Hiroharu, Urashima, Shu Hei, Onose, Morihiko, Komatani, Shintaro, Nakai, Izumi, Abe, Yoshinari, Terada, Yasuko, Homma, Hisashi, Motomura, Kazuko, Ichida, Kiyohiro, Yokoyama, Tetsuya, Nagashima, Kazuhide, Aléon, Jérôme, Conel, Conel M., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Hoppe, Peter, Huss, Gary R., Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Krot, Sasha, Liu, Ming-Chang, Masuda, Yuki, Moynier, Frédéric, Nguyen, Ann, Nittler, Larry, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Rocco, Tommaso Di, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Young, Edward D., Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, Yurimoto, Hisayoshi, Morita, Mayu, Yui, Hiroharu, Urashima, Shu Hei, Onose, Morihiko, Komatani, Shintaro, Nakai, Izumi, Abe, Yoshinari, Terada, Yasuko, Homma, Hisashi, Motomura, Kazuko, Ichida, Kiyohiro, Yokoyama, Tetsuya, Nagashima, Kazuhide, Aléon, Jérôme, Conel, Conel M., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Hoppe, Peter, Huss, Gary R., Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Krot, Sasha, Liu, Ming-Chang, Masuda, Yuki, Moynier, Frédéric, Nguyen, Ann, Nittler, Larry, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Rocco, Tommaso Di, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Young, Edward D., Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Abstract

Characterization of the elemental distribution of samples with rough surfaces has been strongly desired for the analysis of various natural and artificial materials. Particularly for pristine and rare analytes with micrometer sizes embedded on specimen surfaces, non-invasive and matrix effect-free analysis is required without surface polishing treatment. To satisfy these requirements, we proposed a new method employing the sequential combination of two imaging modalities, i.e., microenergy-dispersive X-ray fluorescence (micro-XRF) and Raman micro-spectroscopy. The applicability of the developed method is tested by the quantitative analysis of cation composition in micrometer-sized carbonate grains on the surfaces of intact particles sampled directly from the asteroid Ryugu. The first step of micro-XRF imaging enabled a quick search for the sparsely scattered and micrometer-sized carbonates by the codistributions of Ca2+ and Mn2+ on the Mg2+- and Fe2+-rich phyllosilicate matrix. The following step of Raman micro-spectroscopy probed the carbonate grains and analyzed their cation composition (Ca2+, Mg2+, and Fe2+ + Mn2+) in a matrix effect-free manner via the systematic Raman shifts of the lattice modes. The carbonates were basically assigned to ferroan dolomite bearing a considerable amount of Fe2+ + Mn2+ at around 10 atom %. These results are in good accordance with the assignments reported by scanning electron microscopy-energy-dispersive X-ray spectroscopy, where the thin-sectioned and surface-polished Ryugu particles were applicable. The proposed method requires neither sectioning nor surface polishing; hence, it can be applied to the remote sensing apparatus on spacecrafts and planetary rovers. Furthermore, the non-invasive and matrix effect-free characterization will provide a reliable analytical tool for quantitative analysis of the elemental distrib

Published
2024

33. Neodymium‐142 deficits and samarium neutron stratigraphy of C‐type asteroid (162173) Ryugu.

Author

Torrano, Zachary A., Jordan, Michelle K., Mock, Timothy D., Carlson, Richard W., Gautam, Ikshu, Haba, Makiko K., Yokoyama, Tetsuya, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel, Amari, Sachiko, Amelin, Yuri, Bajo, Ken‐ichi, Bizzarro, Martin, Bouvier, Audrey, Chaussidon, Marc, Choi, Byeon‐Gak, Dauphas, Nicolas, Davis, Andrew M., and Di Rocco, Tommaso

Subjects
GALACTIC cosmic rays, NEUTRON capture, MASS spectrometers, CHONDRITES, SAMARIUM
Abstract

We report Nd and Sm isotopic compositions of four samples of Ryugu returned by the Hayabusa2 mission, including "A" (first touchdown) and "C" (second touchdown) samples, and several carbonaceous chondrites to evaluate potential genetic relationships between Ryugu and known chondrite groups and track the cosmic ray exposure history of Ryugu. We resolved Nd and Sm isotopic anomalies in small (<20 ng Nd and Sm) sample sizes via thermal ionization mass spectrometer using 1013 Ω amplifiers. Ryugu samples exhibit resolvable negative μ142Nd values consistent with carbonaceous chondrite values, suggesting that Ryugu is related to the parent bodies of carbonaceous chondrites. Ryugu's negative μ149Sm values are the result of exposure to galactic cosmic rays, as demonstrated by the correlation between 150Sm/152Sm and 149Sm/152Sm ratios that fall along the expected neutron capture correlation line. The neutron fluence calculated in the "A" samples (2.75 ± 1.94 × 1015 n cm−2) is slightly higher compared to the "C" samples (0.95 ± 2.04 × 1015 n cm−2), though overlapping within measurement uncertainty. The Sm results for Ryugu, at this level of precision, thus are consistent with a well‐mixed surface layer at least to the depths from which the "A" and "C" samples derive. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Neodymium‐142 deficits and samarium neutron stratigraphy of C‐type asteroid (162173) Ryugu

Author

Torrano, Zachary A., primary, Jordan, Michelle K., additional, Mock, Timothy D., additional, Carlson, Richard W., additional, Gautam, Ikshu, additional, Haba, Makiko K., additional, Yokoyama, Tetsuya, additional, Abe, Yoshinari, additional, Aléon, Jérôme, additional, Alexander, Conel, additional, Amari, Sachiko, additional, Amelin, Yuri, additional, Bajo, Ken‐ichi, additional, Bizzarro, Martin, additional, Bouvier, Audrey, additional, Chaussidon, Marc, additional, Choi, Byeon‐Gak, additional, Dauphas, Nicolas, additional, Davis, Andrew M., additional, Di Rocco, Tommaso, additional, Fujiya, Wataru, additional, Fukai, Ryota, additional, Hibiya, Yuki, additional, Hidaka, Hiroshi, additional, Homma, Hisashi, additional, Hoppe, Peter, additional, Huss, Gary R., additional, Ichida, Kiyohiro, additional, Iizuka, Tsuyoshi, additional, Ireland, Trevor, additional, Ishikawa, Akira, additional, Itoh, Shoichi, additional, Kawasaki, Noriyuki, additional, Kita, Noriko T., additional, Kitajima, Koki, additional, Kleine, Thorsten, additional, Komatani, Shintaro, additional, Krot, Alexander N., additional, Liu, Ming‐Chang, additional, Masuda, Yuki, additional, McKeegan, Kevin D., additional, Morita, Mayu, additional, Motomura, Kazuko, additional, Moynier, Frédéric, additional, Nakai, Izumi, additional, Nagashima, Kazuhide, additional, Nguyen, Ann, additional, Nittler, Larry, additional, Onose, Morihiko, additional, Pack, Andreas, additional, Park, Changkun, additional, Piani, Laurette, additional, Qin, Liping, additional, Russell, Sara, additional, Sakamoto, Naoya, additional, Schönbächler, Maria, additional, Tafla, Lauren, additional, Tang, Haolan, additional, Terada, Kentaro, additional, Terada, Yasuko, additional, Usui, Tomohiro, additional, Wada, Sohei, additional, Wadhwa, Meenakshi, additional, Walker, Richard J., additional, Yamashita, Katsuyuki, additional, Yin, Qing‐Zhu, additional, Yoneda, Shigekazu, additional, Young, Edward D., additional, Yui, Hiroharu, additional, Zhang, Ai‐Cheng, additional, Nakamura, Tomoki, additional, Naraoka, Hiroshi, additional, Noguchi, Takaaki, additional, Okazaki, Ryuji, additional, Sakamoto, Kanako, additional, Yabuta, Hikaru, additional, Abe, Masanao, additional, Miyazaki, Akiko, additional, Nakato, Aiko, additional, Nishimura, Masahiro, additional, Okada, Tatsuaki, additional, Yada, Toru, additional, Yogata, Kasumi, additional, Nakazawa, Satoru, additional, Saiki, Takanao, additional, Tanaka, Satoshi, additional, Terui, Fuyuto, additional, Tsuda, Yuichi, additional, Watanabe, Sei‐ichiro, additional, Yoshikawa, Makoto, additional, Tachibana, Shogo, additional, and Yurimoto, Hisayoshi, additional

Published
2023
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37. Live two‐way video versus face‐to‐face treatment for depression, anxiety, and obsessive‐compulsive disorder: A 24‐week randomized controlled trial.

Author

Kishimoto, Taishiro, Kinoshita, Shotaro, Kitazawa, Momoko, Hishimoto, Akitoyo, Asami, Takeshi, Suda, Akira, Bun, Shogyoku, Kikuchi, Toshiaki, Sado, Mitsuhiro, Takamiya, Akihiro, Mimura, Masaru, Sato, Yasunori, Takemura, Ryo, Nagashima, Kengo, Nakamae, Takashi, Abe, Yoshinari, Kanazawa, Tetsufumi, Kawabata, Yasuo, Tomita, Hiroaki, and Abe, Koichi

Subjects
OBSESSIVE-compulsive disorder, ANXIETY disorders, RANDOMIZED controlled trials, TREATMENT effectiveness, MENTAL health surveys, PSYCHIATRIC treatment
Abstract

Aim: Live two‐way video, easily accessible from home via smartphones and other devices, is becoming a new way of providing psychiatric treatment. However, lack of evidence for real‐world clinical setting effectiveness hampers its approval by medical insurance in some countries. Here, we conducted the first large‐scale pragmatic, randomized controlled trial to determine the effectiveness of long‐term treatment for multiple psychiatric disorders via two‐way video using smartphones and other devices, which are currently the primary means of telecommunication. Methods: This randomized controlled trial compared two‐way video versus face‐to‐face treatment for depressive disorder, anxiety disorder, and obsessive‐compulsive disorder in the subacute/maintenance phase during a 24‐week period. Adult patients with the above‐mentioned disorders were allocated to either a two‐way video group (≥50% video sessions) or a face‐to‐face group (100% in‐person sessions) and received standard treatment covered by public medical insurance. The primary outcome was the 36‐Item Short‐Form Health Survey Mental Component Summary (SF‐36 MCS) score. Secondary outcomes included all‐cause discontinuation, working alliance, adverse events, and the severity rating scales for each disorder. Results: A total of 199 patients participated in this study. After 24 weeks of treatment, two‐way video treatment was found to be noninferior to face‐to‐face treatment regarding SF‐36 MCS score (48.50 vs 46.68, respectively; p < 0.001). There were no significant differences between the groups regarding most secondary end points, including all‐cause discontinuation, treatment efficacy, and satisfaction. Conclusion: Two‐way video treatment using smartphones and other devices, was noninferior to face‐to‐face treatment in real‐world clinical settings. Modern telemedicine, easily accessible from home, can be used as a form of health care. [ABSTRACT FROM AUTHOR]

Published
2024
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38. The Magnesium Isotope Composition of Samples Returned from Asteroid Ryugu

Author

Bizzarro, Martin, primary, Schiller, Martin, additional, Yokoyama, Tetsuya, additional, Abe, Yoshinari, additional, Aléon, Jérôme, additional, Alexander, Conel M. O’D., additional, Amari, Sachiko, additional, Amelin, Yuri, additional, Bajo, Ken-ichi, additional, Bouvier, Audrey, additional, Carlson, Richard W., additional, Chaussidon, Marc, additional, Choi, Byeon-Gak, additional, Dauphas, Nicolas, additional, Davis, Andrew M., additional, Di Rocco, Tommaso, additional, Fujiya, Wataru, additional, Fukai, Ryota, additional, Gautam, Ikshu, additional, Haba, Makiko K., additional, Hibiya, Yuki, additional, Hidaka, Hiroshi, additional, Homma, Hisashi, additional, Hoppe, Peter, additional, Huss, Gary R., additional, Ichida, Kiyohiro, additional, Iizuka, Tsuyoshi, additional, Ireland, Trevor R., additional, Ishikawa, Akira, additional, Itoh, Shoichi, additional, Kawasaki, Noriyuki, additional, Kita, Noriko T., additional, Kitajima, Kouki, additional, Kleine, Thorsten, additional, Komatani, Shintaro, additional, Krot, Alexander N., additional, Liu, Ming-Chang, additional, Masuda, Yuki, additional, Morita, Mayu, additional, Moynier, Fréderic, additional, Motomura, Kazuko, additional, Nakai, Izumi, additional, Nagashima, Kazuhide, additional, Nesvorný, David, additional, Nguyen, Ann, additional, Nittler, Larry, additional, Onose, Morihiko, additional, Pack, Andreas, additional, Park, Changkun, additional, Piani, Laurette, additional, Qin, Liping, additional, Russell, Sara S., additional, Sakamoto, Naoya, additional, Schönbächler, Maria, additional, Tafla, Lauren, additional, Tang, Haolan, additional, Terada, Kentaro, additional, Terada, Yasuko, additional, Usui, Tomohiro, additional, Wada, Sohei, additional, Wadhwa, Meenakshi, additional, Walker, Richard J., additional, Yamashita, Katsuyuki, additional, Yin, Qing-Zhu, additional, Yoneda, Shigekazu, additional, Young, Edward D., additional, Yui, Hiroharu, additional, Zhang, Ai-Cheng, additional, Nakamura, Tomoki, additional, Naraoka, Hiroshi, additional, Noguchi, Takaaki, additional, Okazaki, Ryuji, additional, Sakamoto, Kanako, additional, Yabuta, Hikaru, additional, Abe, Masanao, additional, Miyazaki, Akiko, additional, Nakato, Aiko, additional, Nishimura, Masahiro, additional, Okada, Tatsuaki, additional, Yada, Toru, additional, Yogata, Kasumi, additional, Nakazawa, Satoru, additional, Saiki, Takanao, additional, Tanaka, Satoshi, additional, Terui, Fuyuto, additional, Tsuda, Yuichi, additional, Watanabe, Sei-ichiro, additional, Yoshikawa, Makoto, additional, Tachibana, Shogo, additional, and Yurimoto, Hisayoshi, additional

Published
2023
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43. The Oxygen Isotopic Composition of Samples Returned from Asteroid Ryugu with Implications for the Nature of the Parent Planetesimal

Author

Tang, Haolan, primary, Young, Edward D., additional, Tafla, Lauren, additional, Pack, Andreas, additional, Di Rocco, Tommaso, additional, Abe, Yoshinari, additional, Aléon, Jérôme, additional, M. O’D. Alexander, Conel, additional, Amari, Sachiko, additional, Amelin, Yuri, additional, Bajo, Ken-ichi, additional, Bizzarro, Martin, additional, Bouvier, Audrey, additional, Carlson, Richard W., additional, Chaussidon, Marc, additional, Choi, Byeon-Gak, additional, Dauphas, Nicolas, additional, Davis, Andrew M., additional, Fujiya, Wataru, additional, Fukai, Ryota, additional, Gautam, Ikshu, additional, Haba, Makiko K., additional, Hibiya, Yuki, additional, Hidaka, Hiroshi, additional, Homma, Hisashi, additional, Hoppe, Peter, additional, Huss, Gary R., additional, Ichida, Kiyohiro, additional, Iizuka, Tsuyoshi, additional, Ireland, Trevor R., additional, Ishikawa, Akira, additional, Ito, Motoo, additional, Itoh, Shoichi, additional, Kawasaki, Noriyuki, additional, Kita, Noriko T., additional, Kitajima, Kouki, additional, Kleine, Thorsten, additional, Komatani, Shintaro, additional, Krot, Alexander N., additional, Liu, Ming-Chang, additional, Masuda, Yuki, additional, McKeegan, Kevin D., additional, Morita, Mayu, additional, Motomura, Kazuko, additional, Moynier, Frédéric, additional, Nagashima, Kazuhide, additional, Nakai, Izumi, additional, Nguyen, Ann, additional, Nittler, Larry, additional, Onose, Morihiko, additional, Park, Changkun, additional, Piani, Laurette, additional, Qin, Liping, additional, Russell, Sara S., additional, Sakamoto, Naoya, additional, Schönbächler, Maria, additional, Terada, Kentaro, additional, Terada, Yasuko, additional, Usui, Tomohiro, additional, Wada, Sohei, additional, Wadhwa, Meenakshi, additional, Walker, Richard J., additional, Yamashita, Katsuyuki, additional, Yin, Qing-Zhu, additional, Yokoyama, Tetsuya, additional, Yoneda, Shigekazu, additional, Yui, Hiroharu, additional, Zhang, Ai-Cheng, additional, Nakamura, Tomoki, additional, Naraoka, Hiroshi, additional, Noguchi, Takaaki, additional, Okazaki, Ryuji, additional, Sakamoto, Kanako, additional, Yabuta, Hikaru, additional, Abe, Masanao, additional, Miyazaki, Akiko, additional, Nakato, Aiko, additional, Nishimura, Masahiro, additional, Okada, Tatsuaki, additional, Yada, Toru, additional, Yogata, Kasumi, additional, Nakazawa, Satoru, additional, Saiki, Takanao, additional, Tanaka, Satoshi, additional, Terui, Fuyuto, additional, Tsuda, Yuichi, additional, Watanabe, Sei-ichiro, additional, Yoshikawa, Makoto, additional, Tachibana, Shogo, additional, and Yurimoto, Hisayoshi, additional

Published
2023
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45. Hydrogen Isotopic Composition of Hydrous Minerals in Asteroid Ryugu

Author

Piani, Laurette, primary, Nagashima, Kazuhide, additional, Kawasaki, Noriyuki, additional, Sakamoto, Naoya, additional, Bajo, Ken-ichi, additional, Abe, Yoshinari, additional, Aléon, Jérôme, additional, O’D. Alexander, Conel M., additional, Amari, Sachiko, additional, Amelin, Yuri, additional, Bizzarro, Martin, additional, Bouvier, Audrey, additional, Carlson, Richard W., additional, Chaussidon, Marc, additional, Choi, Byeon-Gak, additional, Dauphas, Nicolas, additional, Davis, Andrew M., additional, Di Rocco, Tommaso, additional, Fujiya, Wataru, additional, Fukai, Ryota, additional, Gautam, Ikshu, additional, Haba, Makiko K., additional, Hibiya, Yuki, additional, Hidaka, Hiroshi, additional, Homma, Hisashi, additional, Hoppe, Peter, additional, Huss, Gary R., additional, Ichida, Kiyohiro, additional, Iizuka, Tsuyoshi, additional, Ireland, Trevor R., additional, Ishikawa, Akira, additional, Itoh, Shoichi, additional, Kita, Noriko T., additional, Kitajima, Kouki, additional, Kleine, Thorsten, additional, Komatani, Shintaro, additional, Krot, Alexander N., additional, Liu, Ming-Chang, additional, Masuda, Yuki, additional, McKeegan, Kevin D., additional, Morita, Mayu, additional, Motomura, Kazuko, additional, Moynier, Frédéric, additional, Nakai, Izumi, additional, Nguyen, Ann, additional, Nittler, Larry, additional, Onose, Morihiko, additional, Pack, Andreas, additional, Park, Changkun, additional, Qin, Liping, additional, Russell, Sara S., additional, Schönbächler, Maria, additional, Tafla, Lauren, additional, Tang, Haolan, additional, Terada, Kentaro, additional, Terada, Yasuko, additional, Usui, Tomohiro, additional, Wada, Sohei, additional, Wadhwa, Meenakshi, additional, Walker, Richard J., additional, Yamashita, Katsuyuki, additional, Yin, Qing-Zhu, additional, Yokoyama, Tetsuya, additional, Yoneda, Shigekazu, additional, Young, Edward D., additional, Yui, Hiroharu, additional, Zhang, Ai-Cheng, additional, Nakamura, Tomoki, additional, Naraoka, Hiroshi, additional, Okazaki, Ryuji, additional, Sakamoto, Kanako, additional, Yabuta, Hikaru, additional, Abe, Masanao, additional, Miyazaki, Akiko, additional, Nakato, Aiko, additional, Nishimura, Masahiro, additional, Okada, Tatsuaki, additional, Yada, Toru, additional, Yogata, Kasumi, additional, Nakazawa, Satoru, additional, Saiki, Takanao, additional, Tanaka, Satoshi, additional, Terui, Fuyuto, additional, Tsuda, Yuichi, additional, Watanabe, Sei-ichiro, additional, Yoshikawa, Makoto, additional, Tachibana, Shogo, additional, and Yurimoto, Hisayoshi, additional

Published
2023
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47. Carbonate record of temporal change in oxygen fugacity and gaseous species in asteroid Ryugu

Author

Fujiya, Wataru, Kawasaki, Noriyuki, Nagashima, Kazuhide, Sakamoto, Naoya, O'D. Alexander, Conel M., Kita, Noriko T., Kitajima, Kouki, Abe, Yoshinari, Aleon, Jerome, Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Moynier, Frederic, Nakai, Izumi, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Schonbachler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yokoyama, Tetsuya, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, Yurimoto, Hisayoshi, Fujiya, Wataru, Kawasaki, Noriyuki, Nagashima, Kazuhide, Sakamoto, Naoya, O'D. Alexander, Conel M., Kita, Noriko T., Kitajima, Kouki, Abe, Yoshinari, Aleon, Jerome, Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Moynier, Frederic, Nakai, Izumi, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Schonbachler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yokoyama, Tetsuya, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Abstract

The Hayabusa2 spacecraft explored asteroid Ryugu and brought its surface materials to Earth. Ryugu samples resemble Ivuna-type (CI) chondrites-the most chemically primitive meteorites-and contain secondary phyllosilicates and carbonates, which are indicative of aqueous alteration. Understanding the conditions (such as temperature, redox state and fluid composition) during aqueous alteration is crucial to elucidating how Ryugu evolved to its present state, but little is known about the temporal changes in these conditions. Here we show that calcium carbonate (calcite) grains in Ryugu and Ivuna samples have variable O-18/O-16 and C-13/C-12 ratios that are, respectively, 24-46 & PTSTHOUSND; and 65-108 & PTSTHOUSND; greater than terrestrial standard values, whereas those of calcium-magnesium carbonate (dolomite) grains are much more homogeneous, ranging within 31-36 & PTSTHOUSND; for oxygen and 67-75 & PTSTHOUSND; for carbon. We infer that the calcite precipitated first over a wide range of temperatures and oxygen partial pressures, and that the proportion of gaseous CO2/CO/CH4 molecules changed temporally. By contrast, the dolomite formed later in a more oxygen-rich and thus CO2-dominated environment when the system was approaching equilibrium. The characteristic isotopic compositions of secondary carbonates in Ryugu and Ivuna are not observed for other hydrous meteorites, suggesting a unique evolutionary pathway for their parent asteroid(s). The asteroid Ryugu experienced aqueous alteration under changing temperature and redox conditions, according to an isotopic analysis of secondary calcite and dolomite grains in samples from Ryugu obtained by the Hayabusa2 spacecraft.

Published
2023

48. The Oxygen Isotopic Composition of Samples Returned from Asteroid Ryugu with Implications for the Nature of the Parent Planetesimal

Author

Tang, Haolan, Young, Edward D., Tafla, Lauren, Pack, Andreas, Di Rocco, Tommaso, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel M. O'D., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Ito, Motoo, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Moynier, Frédéric, Nagashima, Kazuhide, Nakai, Izumi, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yokoyama, Tetsuya, Yoneda, Shigekazu, Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, Yurimoto, Hisayoshi, Tang, Haolan, Young, Edward D., Tafla, Lauren, Pack, Andreas, Di Rocco, Tommaso, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel M. O'D., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Ito, Motoo, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Moynier, Frédéric, Nagashima, Kazuhide, Nakai, Izumi, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yokoyama, Tetsuya, Yoneda, Shigekazu, Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Abstract

We present oxygen isotopic analyses of fragments of the near-Earth Cb-type asteroid Ryugu returned by the Hayabusa2 spacecraft that reinforce the close correspondence between Ryugu and CI chondrites. Small differences between Ryugu samples and CI chondrites in can be explained at least in part by contamination of the latter by terrestrial water. The discovery that a randomly sampled C-complex asteroid is composed of CI-chondrite-like rock, combined with thermal models for formation prior to significant decay of the short-lived radioisotope 26Al, suggests that if lithified at the time of alteration, the parent body was small (≪50 km radius). If the parent planetesimal was large (>50 km in radius), it was likely composed of high-permeability, poorly lithified sediment rather than consolidated rock., We present oxygen isotopic analyses of fragments of the near-Earth Cb-type asteroid Ryugu returned by the Hayabusa2 spacecraft that reinforce the close correspondence between Ryugu and CI chondrites. Small differences between Ryugu samples and CI chondrites in can be explained at least in part by contamination of the latter by terrestrial water. The discovery that a randomly sampled C-complex asteroid is composed of CI-chondrite-like rock, combined with thermal models for formation prior to significant decay of the short-lived radioisotope 26Al, suggests that if lithified at the time of alteration, the parent body was small (≪50 km radius). If the parent planetesimal was large (>50 km in radius), it was likely composed of high-permeability, poorly lithified sediment rather than consolidated rock.

Published
2023

49. Abundant presolar grains and primordial organics preserved in carbon-rich exogenous clasts in asteroid Ryugu

Author

Nguyen, Ann N., Mane, Prajkta, Keller, Lindsay P., Piani, Laurette, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel M. O'D., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Moynier, Frédéric, Nakai, Izumi, Nagashima, Kazuhide, Nesvorný, David, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yokoyama, Tetsuya, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, Yurimoto, Hisayoshi, Nguyen, Ann N., Mane, Prajkta, Keller, Lindsay P., Piani, Laurette, Abe, Yoshinari, Aléon, Jérôme, Alexander, Conel M. O'D., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Bouvier, Audrey, Carlson, Richard W., Chaussidon, Marc, Choi, Byeon-Gak, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Moynier, Frédéric, Nakai, Izumi, Nagashima, Kazuhide, Nesvorný, David, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schönbächler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yokoyama, Tetsuya, Yoneda, Shigekazu, Young, Edward D., Yui, Hiroharu, Zhang, Ai-Cheng, Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Miyazaki, Akiko, Nakato, Aiko, Nishimura, Masahiro, Okada, Tatsuaki, Yada, Toru, Yogata, Kasumi, Nakazawa, Satoru, Saiki, Takanao, Tanaka, Satoshi, Terui, Fuyuto, Tsuda, Yuichi, Watanabe, Sei-ichiro, Yoshikawa, Makoto, Tachibana, Shogo, and Yurimoto, Hisayoshi

Abstract

Preliminary analyses of asteroid Ryugu samples show kinship to aqueously altered CI (Ivuna-type) chondrites, suggesting similar origins. We report identification of C-rich, particularly primitive clasts in Ryugu samples that contain preserved presolar silicate grains and exceptional abundances of presolar SiC and isotopically anomalous organic matter. The high presolar silicate abundance (104 ppm) indicates that the clast escaped extensive alteration. The 5 to 10 times higher abundances of presolar SiC (~235 ppm), N-rich organic matter, organics with N isotopic anomalies (1.2%), and organics with C isotopic anomalies (0.2%) in the primitive clasts compared to bulk Ryugu suggest that the clasts formed in a unique part of the protoplanetary disk enriched in presolar materials. These clasts likely represent previously unsampled outer solar system material that accreted onto Ryugu after aqueous alteration ceased, consistent with Ryugu's rubble pile origin.

Published
2023

50. Samples returned from the asteroid Ryugu are similar to Ivuna-type carbonaceous meteorites

Author

Yokoyama, Tetsuya, Nagashima, Kazuhide, Nakai, Izumi, Young, Edward D., Abe, Yoshinari, Aleon, Jerome, Alexander, Conel M. O'D., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Namiki, Noriyuki, Noda, Hirotomo, Noguchi, Rina, Ogawa, Naoko, Ogawa, Kazunori, Okada, Tatsuaki, Okamoto, Chisato, Ono, Go, Ozaki, Masanobu, Saiki, Takanao, Bouvier, Audrey, Sakatani, Naoya, Sawada, Hirotaka, Senshu, Hiroki, Shimaki, Yuri, Shirai, Kei, Sugita, Seiji, Takei, Yuto, Takeuchi, Hiroshi, Tanaka, Satoshi, Tatsumi, Eri, Carlson, Richard W., Terui, Fuyuto, Tsuda, Yuichi, Tsukizaki, Ryudo, Wada, Koji, Watanabe, Sei-ichiro, Yamada, Manabu, Yamada, Tetsuya, Yamamoto, Yukio, Yano, Hajime, Yokota, Yasuhiro, Chaussidon, Marc, Yoshihara, Keisuke, Yoshikawa, Makoto, Yoshikawa, Kent, Furuya, Shizuho, Hatakeda, Kentaro, Hayashi, Tasuku, Hitomi, Yuya, Kumagai, Kazuya, Miyazaki, Akiko, Nakato, Aiko, Choi, Byeon-Gak, Nishimura, Masahiro, Soejima, Hiromichi, Suzuki, Ayako, Yada, Toru, Yamamoto, Daiki, Yogata, Kasumi, Yoshitake, Miwa, Tachibana, Shogo, Yurimoto, Hisayoshi, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Ito, Motoo, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Moynier, Frederic, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schoenbaechler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Yui, Hiroharu, Zhang, Ai-Cheng, Connolly Jr, Harold C., Lauretta, Dante S., Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Arakawa, Masahiko, Fujii, Atsushi, Hayakawa, Masahiko, Hirata, Naoyuki, Hirata, Naru, Honda, Rie, Honda, Chikatoshi, Hosoda, Satoshi, Iijima, Yu-ichi, Ikeda, Hitoshi, Ishiguro, Masateru, Ishihara, Yoshiaki, Iwata, Takahiro, Kawahara, Kosuke, Kikuchi, Shota, Kitazato, Kohei, Matsumoto, Koji, Matsuoka, Moe, Michikami, Tatsuhiro, Mimasu, Yuya, Miura, Akira, Morota, Tomokatsu, Nakazawa, Satoru, Yokoyama, Tetsuya, Nagashima, Kazuhide, Nakai, Izumi, Young, Edward D., Abe, Yoshinari, Aleon, Jerome, Alexander, Conel M. O'D., Amari, Sachiko, Amelin, Yuri, Bajo, Ken-ichi, Bizzarro, Martin, Namiki, Noriyuki, Noda, Hirotomo, Noguchi, Rina, Ogawa, Naoko, Ogawa, Kazunori, Okada, Tatsuaki, Okamoto, Chisato, Ono, Go, Ozaki, Masanobu, Saiki, Takanao, Bouvier, Audrey, Sakatani, Naoya, Sawada, Hirotaka, Senshu, Hiroki, Shimaki, Yuri, Shirai, Kei, Sugita, Seiji, Takei, Yuto, Takeuchi, Hiroshi, Tanaka, Satoshi, Tatsumi, Eri, Carlson, Richard W., Terui, Fuyuto, Tsuda, Yuichi, Tsukizaki, Ryudo, Wada, Koji, Watanabe, Sei-ichiro, Yamada, Manabu, Yamada, Tetsuya, Yamamoto, Yukio, Yano, Hajime, Yokota, Yasuhiro, Chaussidon, Marc, Yoshihara, Keisuke, Yoshikawa, Makoto, Yoshikawa, Kent, Furuya, Shizuho, Hatakeda, Kentaro, Hayashi, Tasuku, Hitomi, Yuya, Kumagai, Kazuya, Miyazaki, Akiko, Nakato, Aiko, Choi, Byeon-Gak, Nishimura, Masahiro, Soejima, Hiromichi, Suzuki, Ayako, Yada, Toru, Yamamoto, Daiki, Yogata, Kasumi, Yoshitake, Miwa, Tachibana, Shogo, Yurimoto, Hisayoshi, Dauphas, Nicolas, Davis, Andrew M., Di Rocco, Tommaso, Fujiya, Wataru, Fukai, Ryota, Gautam, Ikshu, Haba, Makiko K., Hibiya, Yuki, Hidaka, Hiroshi, Homma, Hisashi, Hoppe, Peter, Huss, Gary R., Ichida, Kiyohiro, Iizuka, Tsuyoshi, Ireland, Trevor R., Ishikawa, Akira, Ito, Motoo, Itoh, Shoichi, Kawasaki, Noriyuki, Kita, Noriko T., Kitajima, Kouki, Kleine, Thorsten, Komatani, Shintaro, Krot, Alexander N., Liu, Ming-Chang, Masuda, Yuki, McKeegan, Kevin D., Morita, Mayu, Motomura, Kazuko, Moynier, Frederic, Nguyen, Ann, Nittler, Larry, Onose, Morihiko, Pack, Andreas, Park, Changkun, Piani, Laurette, Qin, Liping, Russell, Sara S., Sakamoto, Naoya, Schoenbaechler, Maria, Tafla, Lauren, Tang, Haolan, Terada, Kentaro, Terada, Yasuko, Usui, Tomohiro, Wada, Sohei, Wadhwa, Meenakshi, Walker, Richard J., Yamashita, Katsuyuki, Yin, Qing-Zhu, Yoneda, Shigekazu, Yui, Hiroharu, Zhang, Ai-Cheng, Connolly Jr, Harold C., Lauretta, Dante S., Nakamura, Tomoki, Naraoka, Hiroshi, Noguchi, Takaaki, Okazaki, Ryuji, Sakamoto, Kanako, Yabuta, Hikaru, Abe, Masanao, Arakawa, Masahiko, Fujii, Atsushi, Hayakawa, Masahiko, Hirata, Naoyuki, Hirata, Naru, Honda, Rie, Honda, Chikatoshi, Hosoda, Satoshi, Iijima, Yu-ichi, Ikeda, Hitoshi, Ishiguro, Masateru, Ishihara, Yoshiaki, Iwata, Takahiro, Kawahara, Kosuke, Kikuchi, Shota, Kitazato, Kohei, Matsumoto, Koji, Matsuoka, Moe, Michikami, Tatsuhiro, Mimasu, Yuya, Miura, Akira, Morota, Tomokatsu, and Nakazawa, Satoru

Abstract

Carbonaceous meteorites are thought to be fragments of C-type (carbonaceous) asteroids. Samples of the C-type asteroid (162173) Ryugu were retrieved by the Hayabusa2 spacecraft. We measured the mineralogy and bulk chemical and isotopic compositions of Ryugu samples. The samples are mainly composed of materials similar to those of carbonaceous chondrite meteorites, particularly the CI (Ivuna-type) group. The samples consist predominantly of minerals formed in aqueous fluid on a parent planetesimal. The primary minerals were altered by fluids at a temperature of 37 degrees +/- 10 degrees C, about 5.2(-0.7)(+0.8) million (statistical) or 5.2(-2.1)(+1.6) million (systematic) years after the formation of the first solids in the Solar System. After aqueous alteration, the Ryugu samples were likely never heated above similar to 100 degrees C. The samples have a chemical composition that more closely resembles that of the Sun's photosphere than other natural samples do.

Published
2023

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