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1. Impact of COVID-19 and vaccination campaign on 1,755 systemic sclerosis patients during first three years of pandemic. Possible risks for individuals with impaired immunoreactivity to vaccine, ongoing immunomodulating treatments, and disease-related lung involvement during the next pandemic phase

Author

Ferri, Clodoveo, Raimondo, Vincenzo, Giuggioli, Dilia, Gragnani, Laura, Lorini, Serena, Dagna, Lorenzo, Bosello, Silvia Laura, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Cuomo, Giovanna, Tavoni, Antonio, De Angelis, Rossella, Cacciapaglia, Fabio, Zanatta, Elisabetta, Cozzi, Franco, Murdaca, Giuseppe, Cavazzana, Ilaria, Romeo, Nicoletta, Codullo, Veronica, Pellegrini, Roberta, Varcasia, Giuseppe, De Santis, Maria, Selmi, Carlo, Abignano, Giuseppina, Caminiti, Maurizio, L'Andolina, Massimo, Olivo, Domenico, Lubrano, Ennio, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Ruscitti, Piero, Urraro, Teresa, Visentini, Marcella, Bellando-Randone, Silvia, Visalli, Elisa, Testa, Davide, Sciascia, Gabriella, Masini, Francesco, Pellegrino, Greta, Saccon, Francesca, Balestri, Eugenia, Elia, Giusy, Ferrari, Silvia Martina, Tonutti, Antonio, Dall’Ara, Francesca, Pagano Mariano, Giuseppa, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Dal Bosco, Ylenia, Foti, Roberta, Di Cola, Ilenia, Scorpiniti, Daniela, Fusaro, Enrico, Ferrari, Tommaso, Gigliotti, Pietro, Campochiaro, Corrado, Francioso, Francesca, Iandoli, Carlo, Caira, Virginia, Zignego, Anna Linda, D'Angelo, Salvatore, Franceschini, Franco, Matucci-Cerinic, Marco, Giacomelli, Roberto, Doria, Andrea, Santini, Stefano Angelo, Fallahi, Poupak, Iannone, Florenzo, and Antonelli, Alessandro

Published
2023
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3. Stratification in systemic sclerosis according to autoantibody status versus skin involvement: a study of the prospective EUSTAR cohort

Author

Matucci Cerinic, Marco, Walker, Ulrich, Iannone, Florenzo, Jordan, Suzana, Becvar, Radim, Kowal Bielecka, Otylia, Cutolo, Maurizio, Cuomo, Giovanna, Kedor, Claudia, Rednic, Simona, Avouac, Jérome, Vlachoyiannopoulos, P., Montecucco, C., Stork, Jiri, Inanc, Murat, Carreira, Patricia E., Novak, Srdan, Czirják, László, Iudici, Michele, Kucharz, Eugene J., Zanatta, Elisabetta, Perdan-Pirkmajer, Katja, Coleiro, Bernard, Moroncini, Gianluca, Farge Bancel, Dominique, Airò, Paolo, Hesselstrand, Roger, Radic, Mislav, Braun-Moscovici, Yolanda, Lo Monaco, Andrea, Hunzelmann, Nicolas, Pellerito, Raffaele, Giollo, Alessandro, Morovic-Vergles, Jadranka, Denton, Christopher, Vonk, Madelon, Damjanov, Nemanja, Henes, Jörg, Ortiz Santamaria, Vera, Heitmann, Stefan, Krasowska, Dorota, Hasler, Paul, Kohm, Michaela, Foeldvari, Ivan, Bajocchi, Gianluigi, Salvador, Maria João, Stamenkovic, Bojana, Selmi, Carlo Francesco, Tikly, Mohammed, Ananieva, Lidia P., Herrick, Ariane, Müller-Ladner, Ulf, De Palma, Raffaele, Engelhart, Merete, Szücs, Gabriela, Sobrino Grande, Cristina, Midtvedt, Øyvind, Launay, David, Riccieri, Valeria, Ionescu, Ruxandra Maria, Sha, Ami, Gheorghiu, Ana Maria, Sunderkötter, Cord, Ingegnoli, Francesca, Mouthon, Luc, Smith, Vanessa, Cantatore, Francesco Paolo, Ullman, Susanne, Alberto von Mühlen, Carlos, Pozzi, Maria Rosa, Eyerich, Kilian, Wiland, Piotr, Vanthuyne, Marie, Alegre-Sancho, Juan Jose, Herrmann, Kristine, De Langhe, Ellen, Anic, Branimir, Üprus, Maria, Yavuz, Sule, Granel, Brigitte, de Souza Müller, Carolina, Busquets, Joanna, Agachi, Svetlana, Stebbings, Simon, Mathieu, D'Alessandro, Sampaio-Barros, Percival D., Stamp, Lisa, Solanki, Kamal, Veale, Douglas, Loyo, Esthela, Li, Mengtao, Abdel Atty Mohamed, Walid Ahmed, Gigante, Antonietta, Oksel, Fahrettin, Tanaseanu, Cristina-Mihaela, Foti, Rosario, Ancuta, Codrina, Maurer, Britta, van Laar, Jacob, Kayser, Cristiane, Fathi, Nihal, García de la Peña Lefebvre, Paloma, Sibilia, Jean, Litinsky, Ira, Abignano, Giuseppina, Seskute, Goda, Saketkoo, Lesley Ann, Kerzberg, Eduardo, Bianchi, Washington, Castellví, Ivan, Limonta, Massimiliano, Rimar, Doron, Couto, Maura, Spertini, François, Marcoccia, Antonella, Kahl, Sarah, Hsu, Ivien M., Martin, Thierry, Moiseev, Sergey, Chung, Lorinda S., Schmeiser, Tim, Majewski, Dominik, Zdrojewski, Zbigniew, Martínez-Barrio, Julia, Bernardino, Vera, Sommerlatte, Sabine, Levy, Yair, Rezus, Elena, Nuri Pamuk, Omer, Sarzi Puttini, Piercarlo, Poormoghim, Hadi, Kötter, Ina, Gaches, Francis, Belloli, Laura, Sfikakis, Petros, Markus, Juliana, Feldman, Gary R, Ramazan, Ana-Maria, Scherer, H.U., Truchetet, Marie-Elise, Lescoat, Alain, Dagna, Lorenzo, van Laar, J.M., Rudnicka, Lidia, Oliveira, Susana, Atzeni, Fabiola, Kuwana, Masataka, Mekinian, Arsene, Martin, Mickaël, Tanaka, Yoshiya, Elhai, Muriel, Sritharan, Nanthara, Boubaya, Marouane, Balbir-Gurman, Alexandra, Siegert, Elise, Hachulla, Eric, de Vries-Bouwstra, Jeska, Riemekasten, Gabriela, Distler, Jörg H W, Rosato, Edoardo, Del Galdo, Francesco, Mendoza, Fabian A, Furst, Daniel E, de la Puente, Carlos, Hoffmann-Vold, Anna-Maria, Gabrielli, Armando, Distler, Oliver, Bloch-Queyrat, Coralie, and Allanore, Yannick

Published
2022
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4. Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature

Author

Ferri, Clodoveo, De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Lazzaroni, Maria Grazia, Franceschini, Franco, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, and Matucci-Cerinic, Marco

Published
2022
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6. Systemic sclerosis sine scleroderma: clinical and serological features and relationship with other cutaneous subsets in a large series of patients from the national registry ‘SPRING’ of the Italian Society for Rheumatology

Author

Carlo Alberto Scirè, Andrea Doria, Marcello Govoni, Gerolamo Bianchi, Marco Matucci-Cerinic, Florenzo Iannone, Ennio Lubrano, Corrado Campochiaro, Veronica Codullo, Alessandra Della Rossa, Gemma Lepri, Elisabetta Zanatta, Beretta Lorenzo, Doria Andrea, Lepri Gemma, Lorenzo Beretta, Greta Carrara, Alarico Ariani, Simone Parisi, Marta Saracco, Francesco Girelli, Maria De Santis, Federica Lumetti, Dilia Giuggioli, Enrico Fusaro, Simone Barsotti, Ilaria Cavazzana, Federica Furini, Carlo Salvarani, Serena Guiducci, Franco Cozzi, Valeria Riccieri, Francesca Ingegnoli, Edoardo Rosato, Antonietta Gigante, Rosario Foti, Elisa Visalli, Fabio Cacciapaglia, Lorenzo Dagna, Franco Franceschini, Silvia Bellando-Randone, Giovanna Cuomo, Gianluigi Bajocchi, Alessandro Giollo, Giacomo De Luca, Giuseppina Abignano, Carlo Sciré, Anna Zanetti, Giovanni Zanframundo, Edoardo Cipolletta, Silvia Laura Bosello, Clodoveo Ferri, Amelia Spinella, Giuseppa Pagano Mariano, Maurizio Caminiti, Giuseppe Murdaca, Salvatore D'Angelo, Gianpiero Landolfi, Nicoletta Romeo, Gian Domenico Sebastiani, Erika Pigatto, Rossella De Angelis, Davide Rozza, Maria-Grazia Lazzaroni, Anna Maria Iuliano, Giovanni Ciano, Gianluca Bagnato, Ilenia De Andres, Cecilia Agnes, Luca Magnani, Claudio Di Vico, Greta Pellagrino, Elena Generali, Gianna Mennillo, Licia Vultaggio, Clara Lisa Peroni, Abignano Giuseppina, Agnes Cecilia, Amato Giorgio, Ariani Alarico, Bagnato Gianluca, Bajoicchi Gianluigi, Barsotti Simone, Bellando-Randone Silvia, Benenati Alessia, Bianchi Gerolamo, Bosello Silvia, Cacciapaglia Fabio, Calabrese Francesca, Caminiti Maurizio, Campochiaro Corrado, Carignola Renato, Ciano Giovanni, Cipolletta Edoardo, Codullo Veronica, Cozzi Franco, Cuomo Giovanna, D’Angelo Salvatore, Dagna Lorenzo, Dall’Ara Francesca, De Andres Ilenia, De Angelis Rossella, De Cata Angelo, De Luca Giacomo, De Santis Maria, Della Rossa Alessandra, Di Vico Claudio, Doveri Marica, Foti Rosario, Furini Federica, Fusaro Enrico, Generali Elena, Gigante Antonietta, Giollo Alessandro, Girelli Francesco, Giuggioli Dilia, Govoni Marcello, Guiducci Serena, Iannone Florenzo, Ingegnoli Francesca, Iuliano Anna Maria, Lazzaroni Maria Grazia, Lubrano Ennio, Lumetti Federica, Magnani Luca, Mennillo Gianna, Murdaca Giuseppe Ospedale, Pagano Mariano Giuseppa, Parisi Simone, Pellegrino Greta, Peroni Clara Lisa, Pigatto Erika, Riccieri Valeria, Romeo Nicoletta, Rosato Edoardo, Sambataro Gianluca, Saracco Marta, Sebastiani Giandomenico, Spinella Amelia, Talotta Rossella, Visalli Elisa, Vultaggio Licia, Zanatta Elisabetta, and Zanframundo Giovanni

Subjects
Medicine
Abstract

Objective To describe demographic, clinical and laboratory features of systemic sclerosis sine scleroderma (ssSSc) in a large multicentre systemic sclerosis (SSc) cohort.Methods Data involving 1808 SSc patients from Italian Systemic sclerosis PRogression INvestiGation registry were collected. The ssSSc was defined by the absence of any cutaneous sclerosis and/or puffy fingers. Clinical and serological features of ssSSc were compared with limited cutaneous (lcSSc) and diffuse cutaneous (dcSSc) subsets.Results Among patients with SSc, only 61 (3.4%) were classified as having ssSSc (F/M=19/1). Time from Raynaud’s phenomenon (RP) onset to diagnosis was longer in ssSSc (3 years, IQR 1–16.5) than lcSSc (2 years, IQR 0–7), and dcSSc (1 year, IQR 0–3) (p

Published
2023
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9. Practice pattern for the use of intravenous iloprost for the treatment of peripheral vasculopathy in systemic sclerosis: A case-control study from the Italian national multicenter 'SPRING' (Systemic Sclerosis Progression InvestiGation) Registry

Author

Riccieri, Valeria, Pellegrino, Greta, Cipolletta, Edoardo, Giuggioli, Dilia, Bajocchi, Gianluigi, Bellando-Randone, Silvia, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Lepri, Gemma, Girelli, Francesco, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Di Vico, Claudio, Gigante, Antonietta, Saccon, Francesca, Grazia Lazzaroni, Maria, Franceschini, Franco, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Pagano Mariano, Giuseppa, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Bianchi, Gerolamo, Conti, Fabrizio, Cozzi, Franco, D'Angelo, Salvatore, Doria, Andrea, Fusaro, Enrico, Govoni, Marcello, Guiducci, Serena, Iannone, Florenzo, Salvarani, Carlo, Sebastiani, Gian Domenico, Ferri, Clodoveo, Matucci-Cerinic, Marco, De Angelis, Rossella, Bosello, Silvia Laura (ORCID:0000-0002-4837-447X), Riccieri, Valeria, Pellegrino, Greta, Cipolletta, Edoardo, Giuggioli, Dilia, Bajocchi, Gianluigi, Bellando-Randone, Silvia, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Lepri, Gemma, Girelli, Francesco, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Di Vico, Claudio, Gigante, Antonietta, Saccon, Francesca, Grazia Lazzaroni, Maria, Franceschini, Franco, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Pagano Mariano, Giuseppa, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Bianchi, Gerolamo, Conti, Fabrizio, Cozzi, Franco, D'Angelo, Salvatore, Doria, Andrea, Fusaro, Enrico, Govoni, Marcello, Guiducci, Serena, Iannone, Florenzo, Salvarani, Carlo, Sebastiani, Gian Domenico, Ferri, Clodoveo, Matucci-Cerinic, Marco, De Angelis, Rossella, and Bosello, Silvia Laura (ORCID:0000-0002-4837-447X)

Abstract

Background: Intravenous iloprost has been widely used for the treatment of systemic sclerosis peripheral vasculopathy. No agreement has been found on the regimen and the dosage of intravenous iloprost in different scleroderma subset conditions. This study aimed to evaluate the modalities of intravenous iloprost administration within a large cohort of systemic sclerosis patients from the SPRING Registry and to identify any associated clinical-demographic, instrumental or therapeutic data. Patients and methods: Data of systemic sclerosis patients treated with intravenous iloprost for at least 1 year (case group) were retrospectively analyzed, including different timing and duration of intravenous iloprost session, and compared with those of untreated patients (control group). Results: Out of 1895 analyzed patients, 937 (49%) received intravenous iloprost treatment, while 958 (51%) were assigned to the control group. Among cases, about 70% were treated every 4 weeks, 24% with an interval of more than 4 weeks, and only 6% of less than 4 weeks. Most patients receiving the treatment every 4 weeks, or less, underwent infusion cycle for 1 day only, while if it was scheduled with an interval of more than 4 weeks, a total number of 5 consecutive days of infusions was the preferred regimen. The comparison between the two groups revealed that patients treated with intravenous iloprost had a higher frequency of DUs (p < 0.001), pitting scars (p < 0.001), diffuse cutaneous involvement (p < 0.001), interstitial lung disease (p < 0.002), as well as higher rates of anti-topoisomerase I, "late" scleroderma pattern at nailfold videocapillaroscopy. These findings were confirmed by multivariate analysis. Conclusion: Our data provide a picture on the Italian use of intravenous iloprost among systemic sclerosis patients and showed that it was usually employed in patients with a more aggressive spectrum of the disease. The disparity of intravenous iloprost treatment strategies

Published
2024

10. Adherence to the Mediterranean Diet in Italian Patients With Systemic Sclerosis: An Epidemiologic Survey

Author

Natalello, Gerlando, Bosello, Silvia Laura, Campochiaro, Corrado, Abignano, Giuseppina, De Santis, Maria, Ferlito, Arianna, Karadağ, Duygu Temiz, Padula, Angela Anna, Cavalli, Giulio, D'Agostino, Maria Antonietta, Selmi, Carlo, Matucci-Cerinic, Marco, Dagna, Lorenzo, De Luca, Giacomo, Bosello, Silvia Laura (ORCID:0000-0002-4837-447X), D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060), Natalello, Gerlando, Bosello, Silvia Laura, Campochiaro, Corrado, Abignano, Giuseppina, De Santis, Maria, Ferlito, Arianna, Karadağ, Duygu Temiz, Padula, Angela Anna, Cavalli, Giulio, D'Agostino, Maria Antonietta, Selmi, Carlo, Matucci-Cerinic, Marco, Dagna, Lorenzo, De Luca, Giacomo, Bosello, Silvia Laura (ORCID:0000-0002-4837-447X), and D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060)

Abstract

ObjectiveSystemic sclerosis (SSc) is an orphan disease that can lead to severe involvement of the gastrointestinal tract with a significant impact on patients' quality of life (QoL). The Mediterranean diet (MD) was consistently demonstrated to have beneficial effects on chronic diseases based on biological bases. We aimed to evaluate the adherence to the MD of Italian patients with SSc to preliminarily assess its association with gastrointestinal symptoms and other disease features, mood, and QoL.MethodsIn this cross-sectional study, adherence to the MD was measured in 387 patients from four SSc Italian referral centers through the 14-item Mediterranean Diet Adherence Screener (14-MEDAS) questionnaire. We also registered patients' reported outcomes related to the QoL and mood.ResultsOverall, an optimal adherence to MD was observed in 14.7% of patients with SSc, a moderate adherence in 71.3%, and a low adherence in 14.0%. In univariate analysis, poor adherence to the MD was associated with a more prominent depressive mood, time missed at work, and perception of more severe Raynaud's phenomenon and digital ulcers, whereas the 14-MEDAS score inversely correlated with depression score and reflux.ConclusionIn our cohort of patients with SSc, overall adherence to MD was moderate. Patients with lower adherence to MD also reported worse outcomes related to QoL and mood. Administration of the 14-MEDAS could be a reasonable choice to assess adherence to the MD in patients with SSc. Future initiatives to study the role of MD in the management of patients with SSc are warranted.

Published
2024

12. Adherence to the Mediterranean Diet in Italian Patients With Systemic Sclerosis: An Epidemiologic Survey

Author

Natalello, Gerlando, primary, Bosello, Silvia Laura, additional, Campochiaro, Corrado, additional, Abignano, Giuseppina, additional, De Santis, Maria, additional, Ferlito, Arianna, additional, Karadağ, Duygu Temiz, additional, Padula, Angela Anna, additional, Cavalli, Giulio, additional, D'Agostino, Maria Antonietta, additional, Selmi, Carlo, additional, Matucci‐Cerinic, Marco, additional, Dagna, Lorenzo, additional, and De Luca, Giacomo, additional

Published
2023
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13. P162 Biosamples from VEDOSS patients show classic pathological signs of Scleroderma:Opportunity for a biological diagnosis of disease

Author

Ross, Rebecca L, primary, Clarke, Emily, additional, Merchant, Will, additional, Georgiou, Ioanna, additional, Mulipa, Panji, additional, Carriero, Antonio, additional, Abignano, Giuseppina, additional, Herrick, Ariane, additional, Denton, Christopher, additional, Riobo-Del Galdo, Natalia, additional, and Del Galdo, Francesco, additional

Published
2023
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14. Systemic sclerosis sine scleroderma: clinical and serological features and relationship with other cutaneous subsets in a large series of patients from the national registry ‘SPRING’ of the Italian Society for Rheumatology

Author

De Angelis, Rossella, primary, Ferri, Clodoveo, additional, Giuggioli, Dilia, additional, Bajocchi, Gianluigi, additional, Dagna, Lorenzo, additional, Bellando-Randone, Silvia, additional, Zanframundo, Giovanni, additional, Foti, Rosario, additional, Cacciapaglia, Fabio, additional, Cuomo, Giovanna, additional, Ariani, Alarico, additional, Rosato, Edoardo, additional, Lepri, Gemma, additional, Girelli, Francesco, additional, Riccieri, Valeria, additional, Zanatta, Elisabetta, additional, Bosello, Silvia Laura, additional, Cavazzana, Ilaria, additional, Ingegnoli, Francesca, additional, De Santis, Maria, additional, Murdaca, Giuseppe, additional, Abignano, Giuseppina, additional, Romeo, Nicoletta, additional, Della Rossa, Alessandra, additional, Caminiti, Maurizio, additional, Iuliano, Anna Maria, additional, Ciano, Giovanni, additional, Beretta, Lorenzo, additional, Bagnato, Gianluca, additional, Lubrano, Ennio, additional, De Andres, Ilenia, additional, Giollo, Alessandro, additional, Saracco, Marta, additional, Agnes, Cecilia, additional, Cipolletta, Edoardo, additional, Lumetti, Federica, additional, Spinella, Amelia, additional, Magnani, Luca, additional, Campochiaro, Corrado, additional, De Luca, Giacomo, additional, Codullo, Veronica, additional, Visalli, Elisa, additional, Di Vico, Claudio, additional, Gigante, Antonietta, additional, Pellagrino, Greta, additional, Pigatto, Erika, additional, Lazzaroni, Maria-Grazia, additional, Franceschini, Franco, additional, Generali, Elena, additional, Mennillo, Gianna, additional, Barsotti, Simone, additional, Mariano, Giuseppa Pagano, additional, Furini, Federica, additional, Vultaggio, Licia, additional, Parisi, Simone, additional, Peroni, Clara Lisa, additional, Rozza, Davide, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Landolfi, Gianpiero, additional, Scirè, Carlo Alberto, additional, Bianchi, Gerolamo, additional, Fusaro, Enrico, additional, Sebastiani, Gian Domenico, additional, Govoni, Marcello, additional, D'Angelo, Salvatore, additional, Cozzi, Franco, additional, Guiducci, Serena, additional, Doria, Andrea, additional, Salvarani, Carlo, additional, Iannone, Florenzo, additional, and Matucci-Cerinic, Marco, additional

Published
2023
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15. Subclinical Systemic Sclerosis Primary Heart Involvement by Cardiovascular Magnetic Resonance Shows No Significant Interval Change

Author

Dumitru, Raluca B., primary, Bissell, Lesley‐Anne, additional, Erhayiem, Bara, additional, Fent, Graham, additional, Kidambi, Ananth, additional, Abignano, Giuseppina, additional, Greenwood, John P., additional, Biglands, John, additional, Del Galdo, Francesco, additional, Plein, Sven, additional, and Buch, Maya H., additional

Published
2023
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16. Stratification in systemic sclerosis according to autoantibody status versus skin involvement: a study of the prospective EUSTAR cohort

Author

Elhai, Muriel, primary, Sritharan, Nanthara, additional, Boubaya, Marouane, additional, Balbir-Gurman, Alexandra, additional, Siegert, Elise, additional, Hachulla, Eric, additional, de Vries-Bouwstra, Jeska, additional, Riemekasten, Gabriela, additional, Distler, Jörg H W, additional, Rosato, Edoardo, additional, Del Galdo, Francesco, additional, Mendoza, Fabian A, additional, Furst, Daniel E, additional, de la Puente, Carlos, additional, Hoffmann-Vold, Anna-Maria, additional, Gabrielli, Armando, additional, Distler, Oliver, additional, Bloch-Queyrat, Coralie, additional, Allanore, Yannick, additional, Matucci Cerinic, Marco, additional, Walker, Ulrich, additional, Iannone, Florenzo, additional, Jordan, Suzana, additional, Becvar, Radim, additional, Kowal Bielecka, Otylia, additional, Cutolo, Maurizio, additional, Cuomo, Giovanna, additional, Kedor, Claudia, additional, Rednic, Simona, additional, Avouac, Jérome, additional, Vlachoyiannopoulos, P., additional, Montecucco, C., additional, Stork, Jiri, additional, Inanc, Murat, additional, Carreira, Patricia E., additional, Novak, Srdan, additional, Czirják, László, additional, Iudici, Michele, additional, Kucharz, Eugene J., additional, Zanatta, Elisabetta, additional, Perdan-Pirkmajer, Katja, additional, Coleiro, Bernard, additional, Moroncini, Gianluca, additional, Farge Bancel, Dominique, additional, Airò, Paolo, additional, Hesselstrand, Roger, additional, Radic, Mislav, additional, Braun-Moscovici, Yolanda, additional, Lo Monaco, Andrea, additional, Hunzelmann, Nicolas, additional, Pellerito, Raffaele, additional, Giollo, Alessandro, additional, Morovic-Vergles, Jadranka, additional, Denton, Christopher, additional, Vonk, Madelon, additional, Damjanov, Nemanja, additional, Henes, Jörg, additional, Ortiz Santamaria, Vera, additional, Heitmann, Stefan, additional, Krasowska, Dorota, additional, Hasler, Paul, additional, Kohm, Michaela, additional, Foeldvari, Ivan, additional, Bajocchi, Gianluigi, additional, Salvador, Maria João, additional, Stamenkovic, Bojana, additional, Selmi, Carlo Francesco, additional, Tikly, Mohammed, additional, Ananieva, Lidia P., additional, Herrick, Ariane, additional, Müller-Ladner, Ulf, additional, De Palma, Raffaele, additional, Engelhart, Merete, additional, Szücs, Gabriela, additional, Sobrino Grande, Cristina, additional, Midtvedt, Øyvind, additional, Launay, David, additional, Riccieri, Valeria, additional, Ionescu, Ruxandra Maria, additional, Sha, Ami, additional, Gheorghiu, Ana Maria, additional, Sunderkötter, Cord, additional, Ingegnoli, Francesca, additional, Mouthon, Luc, additional, Smith, Vanessa, additional, Cantatore, Francesco Paolo, additional, Ullman, Susanne, additional, Alberto von Mühlen, Carlos, additional, Pozzi, Maria Rosa, additional, Eyerich, Kilian, additional, Wiland, Piotr, additional, Vanthuyne, Marie, additional, Alegre-Sancho, Juan Jose, additional, Herrmann, Kristine, additional, De Langhe, Ellen, additional, Anic, Branimir, additional, Üprus, Maria, additional, Yavuz, Sule, additional, Granel, Brigitte, additional, de Souza Müller, Carolina, additional, Busquets, Joanna, additional, Agachi, Svetlana, additional, Stebbings, Simon, additional, Mathieu, D'Alessandro, additional, Sampaio-Barros, Percival D., additional, Stamp, Lisa, additional, Solanki, Kamal, additional, Veale, Douglas, additional, Loyo, Esthela, additional, Li, Mengtao, additional, Abdel Atty Mohamed, Walid Ahmed, additional, Gigante, Antonietta, additional, Oksel, Fahrettin, additional, Tanaseanu, Cristina-Mihaela, additional, Foti, Rosario, additional, Ancuta, Codrina, additional, Maurer, Britta, additional, van Laar, Jacob, additional, Kayser, Cristiane, additional, Fathi, Nihal, additional, García de la Peña Lefebvre, Paloma, additional, Sibilia, Jean, additional, Litinsky, Ira, additional, Abignano, Giuseppina, additional, Seskute, Goda, additional, Saketkoo, Lesley Ann, additional, Kerzberg, Eduardo, additional, Bianchi, Washington, additional, Castellví, Ivan, additional, Limonta, Massimiliano, additional, Rimar, Doron, additional, Couto, Maura, additional, Spertini, François, additional, Marcoccia, Antonella, additional, Kahl, Sarah, additional, Hsu, Ivien M., additional, Martin, Thierry, additional, Moiseev, Sergey, additional, Chung, Lorinda S., additional, Schmeiser, Tim, additional, Majewski, Dominik, additional, Zdrojewski, Zbigniew, additional, Martínez-Barrio, Julia, additional, Bernardino, Vera, additional, Sommerlatte, Sabine, additional, Levy, Yair, additional, Rezus, Elena, additional, Nuri Pamuk, Omer, additional, Sarzi Puttini, Piercarlo, additional, Poormoghim, Hadi, additional, Kötter, Ina, additional, Gaches, Francis, additional, Belloli, Laura, additional, Sfikakis, Petros, additional, Markus, Juliana, additional, Feldman, Gary R, additional, Ramazan, Ana-Maria, additional, Scherer, H.U., additional, Truchetet, Marie-Elise, additional, Lescoat, Alain, additional, Dagna, Lorenzo, additional, van Laar, J.M., additional, Rudnicka, Lidia, additional, Oliveira, Susana, additional, Atzeni, Fabiola, additional, Kuwana, Masataka, additional, Mekinian, Arsene, additional, Martin, Mickaël, additional, and Tanaka, Yoshiya, additional

Published
2022
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18. Prevalence and Death Rate of COVID-19 in Autoimmune Systemic Diseases in the First Three Pandemic Waves. Relationship with Disease Subgroups and Ongoing Therapies

Author

Ferri, Clodoveo, primary, Antonelli, Alessandro, primary, Raimondo, Vincenzo, additional, Gragnani, Laura, additional, Giuggioli, Dilia, additional, Dagna, Lorenzo, additional, Tavoni, Antonio, additional, Ursini, Francesco, additional, L'Andolina, Massimo, additional, Caso, Francesco, additional, Ruscitti, Piero, additional, Caminiti, Maurizio, additional, Foti, Rosario, additional, Riccieri, Valeria, additional, Guiducci, Serena, additional, Pellegrini, Roberta, additional, Zanatta, Elisabetta, additional, Varcasia, Giuseppe, additional, Olivo, Domenico, additional, Gigliotti, Pietro, additional, Cuomo, Giovanna, additional, Murdaca, Giuseppe, additional, Cecchetti, Riccardo, additional, De Angelis, Rossella, additional, Romeo, Nicoletta, additional, Ingegnoli, Francesca, additional, Cozzi, Franco, additional, Codullo, Veronica, additional, Cavazzana, Ilaria, additional, Colaci, Michele, additional, Abignano, Giuseppina, additional, De Santis, Maria, additional, Lubrano, Ennio, additional, Fusaro, Enrico, additional, Spinella, Amelia, additional, Lumetti, Federica, additional, De Luca, Giacomo, additional, Bellando-Randone, Silvia, additional, Visalli, Elisa, additional, Bosco, Ylenia Dal, additional, Amato, Giorgio, additional, Giannini, Daiana, additional, Bilia, Silvia, additional, Masini, Francesco, additional, Pellegrino, Greta, additional, Pigatto, Erika, additional, Generali, Elena, additional, Mariano, Giuseppa Pagano, additional, Pettiti, Giorgio, additional, Zanframundo, Giovanni, additional, Brittelli, Raffaele, additional, Aiello, Vincenzo, additional, Caminiti, Rodolfo, additional, Scorpiniti, Daniela, additional, Ferrari, Tommaso, additional, Campochiaro, Corrado, additional, Brusi, Veronica, additional, Fredi, Micaela, additional, Moschetti, Liala, additional, Cacciapaglia, Fabio, additional, Paparo, Sabrina Rosaria, additional, Ragusa, Francesca, additional, Mazzi, Valeria, additional, Elia, Giusy, additional, Ferrari, Silvia Martina, additional, Di Cola, Ilenia, additional, Vadacca, Marta, additional, Lorusso, Sebastiano, additional, Monti, Monica, additional, Lorini, Serena, additional, Aprile, Maria Letizia, additional, Tasso, Marco, additional, Miccoli, Mario, additional, Bosello, Silvia, additional, D'Angelo, Salvatore, additional, Doria, Andrea, additional, Franceschini, Franco, additional, Meliconi, Riccardo, additional, Matucci-Cerinic, Marco, additional, Iannone, Florenzo, additional, Giacomelli, Roberto, additional, Salvarani, Carlo, additional, Zignego, Anna Linda, additional, and Fallahi, Poupak, additional

Published
2022
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19. Prevalence and Death Rate of COVID-19 in Autoimmune Systemic Diseases in the First Three Pandemic Waves. Relationship with Disease Subgroups and Ongoing Therapies

Author

Ferri, Clodoveo, Raimondo, Vincenzo, Gragnani, Laura, Giuggioli, Dilia, Dagna, Lorenzo, Tavoni, Antonio, Ursini, Francesco, L'Andolina, Massimo, Caso, Francesco, Ruscitti, Piero, Caminiti, Maurizio, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Pellegrini, Roberta, Zanatta, Elisabetta, Varcasia, Giuseppe, Olivo, Domenico, Gigliotti, Pietro, Cuomo, Giovanna, Murdaca, Giuseppe, Cecchetti, Riccardo, De Angelis, Rossella, Romeo, Nicoletta, Ingegnoli, Francesca, Cozzi, Franco, Codullo, Veronica, Cavazzana, Ilaria, Colaci, Michele, Abignano, Giuseppina, De Santis, Maria, Lubrano, Ennio, Fusaro, Enrico, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Bosco, Ylenia Dal, Amato, Giorgio, Giannini, Daiana, Bilia, Silvia, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Mariano, Giuseppa Pagano, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Ferrari, Tommaso, Campochiaro, Corrado, Brusi, Veronica, Fredi, Micaela, Moschetti, Liala, Cacciapaglia, Fabio, Paparo, Sabrina Rosaria, Ragusa, Francesca, Mazzi, Valeria, Elia, Giusy, Ferrari, Silvia Martina, Di Cola, Ilenia, Vadacca, Marta, Lorusso, Sebastiano, Monti, Monica, Lorini, Serena, Aprile, Maria Letizia, Tasso, Marco, Miccoli, Mario, Bosello, Silvia Laura, D'Angelo, Salvatore, Doria, Andrea, Franceschini, Franco, Meliconi, Riccardo, Matucci-Cerinic, Marco, Iannone, Florenzo, Giacomelli, Roberto, Salvarani, Carlo, Zignego, Anna Linda, Fallahi, Poupak, Antonelli, Alessandro, Bosello, Silvia (ORCID:0000-0002-4837-447X), Ferri, Clodoveo, Raimondo, Vincenzo, Gragnani, Laura, Giuggioli, Dilia, Dagna, Lorenzo, Tavoni, Antonio, Ursini, Francesco, L'Andolina, Massimo, Caso, Francesco, Ruscitti, Piero, Caminiti, Maurizio, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Pellegrini, Roberta, Zanatta, Elisabetta, Varcasia, Giuseppe, Olivo, Domenico, Gigliotti, Pietro, Cuomo, Giovanna, Murdaca, Giuseppe, Cecchetti, Riccardo, De Angelis, Rossella, Romeo, Nicoletta, Ingegnoli, Francesca, Cozzi, Franco, Codullo, Veronica, Cavazzana, Ilaria, Colaci, Michele, Abignano, Giuseppina, De Santis, Maria, Lubrano, Ennio, Fusaro, Enrico, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Bosco, Ylenia Dal, Amato, Giorgio, Giannini, Daiana, Bilia, Silvia, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Mariano, Giuseppa Pagano, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Ferrari, Tommaso, Campochiaro, Corrado, Brusi, Veronica, Fredi, Micaela, Moschetti, Liala, Cacciapaglia, Fabio, Paparo, Sabrina Rosaria, Ragusa, Francesca, Mazzi, Valeria, Elia, Giusy, Ferrari, Silvia Martina, Di Cola, Ilenia, Vadacca, Marta, Lorusso, Sebastiano, Monti, Monica, Lorini, Serena, Aprile, Maria Letizia, Tasso, Marco, Miccoli, Mario, Bosello, Silvia Laura, D'Angelo, Salvatore, Doria, Andrea, Franceschini, Franco, Meliconi, Riccardo, Matucci-Cerinic, Marco, Iannone, Florenzo, Giacomelli, Roberto, Salvarani, Carlo, Zignego, Anna Linda, Fallahi, Poupak, Antonelli, Alessandro, and Bosello, Silvia (ORCID:0000-0002-4837-447X)

Abstract

Objective: Autoimmune systemic diseases (ASD) represent a predisposing condition to COVID-19. Our prospective, observational multicenter telephone survey study aimed to investigate the prevalence, prognostic factors, and outcomes of COVID-19 in Italian ASD patients. Methods: The study included 3,918 ASD pts (815 M, 3103 F; mean age 59 +/- 12SD years) consecutively recruited between March 2020 and May 2021 at the 36 referral centers of COVID-19 and ASD Italian Study Group. The possible development of COVID-19 was recorded by means of a telephone survey using a standardized symptom assessment questionnaire. Results: ASD patients showed a significantly higher prevalence of COVID-19 (8.37% vs. 6.49%; p<0.0001) but a death rate statistically comparable to the Italian general population (3.65% vs. 2.95%). Among the 328 ASD patients developing COVID-19, 17% needed hospitalization, while mild-moderate manifestations were observed in 83% of cases. Moreover, 12/57 hospitalized patients died due to severe interstitial pneumonia and/or cardiovascular events; systemic sclerosis (SSc) patients showed a significantly higher COVID-19-related death rate compared to the general population (6.29% vs. 2.95%; p=0.018). Major adverse prognostic factors to develop COVID-19 were: older age, male gender, SSc, pre-existing ASD-related interstitial lung involvement, and long-term steroid treatment. Of note, patients treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) showed a significantly lower prevalence of COVID-19 compared to those without (3.58% vs. 46.99%; p=0.000), as well as the SSc patients treated with low dose aspirin (with 5.57% vs. without 27.84%; p=0.000). Conclusion: During the first three pandemic waves, ASD patients showed a death rate comparable to the general population despite the significantly higher prevalence of COVID-19. A significantly increased COVID-19-related mortality was recorded in only SSc patients' subgroup, possibly favored

Published
2022

20. Sex-related Differences in Systemic Sclerosis: A Multicenter Cross-sectional Study From the National Registry of the Italian Society for Rheumatology

Author

De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, Santis, Maria De, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Dall'Ara, Francesca, Lazzaroni, Maria Grazia, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Risa, Anna Maria, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, Matucci-Cerinic, Marco, Ferri, Clodoveo, Bosello, Silvia (ORCID:0000-0002-4837-447X), De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, Santis, Maria De, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Dall'Ara, Francesca, Lazzaroni, Maria Grazia, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Risa, Anna Maria, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, Matucci-Cerinic, Marco, Ferri, Clodoveo, and Bosello, Silvia (ORCID:0000-0002-4837-447X)

Abstract

Objective. There is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying sex differences in disease expression, with a special focus on demographic, clinical, and serological characteristics.Methods. A multicenter SSc cohort of 2281 patients, including 247 men, was recruited in the Italian Systemic sclerosis PRogression INvestiGation (SPRING) registry. Demographic data, disease manifestations, serological profile, and internal organ involvement were compared.Results. The overall female/male ratio was 8.2:1. Female/male ratios for limited cutaneous SSc, diffuse cutaneous SSc, and SSc sine scleroderma subsets were 8.7:1, 4.9:1, and 10.7:1, respectively. A shorter time from onset of Raynaud phenomenon to SSc diagnosis, an increased prevalence of the diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, whereas a significantly higher percentage of sicca syndrome, serum antinuclear antibodies, antiextractable nuclear antigens, anti-La/SSB, and anticentromere protein B was detected in the female group. Males exhibited lower left ventricular ejection fraction, as well as higher prevalence of conduction blocks, arrhythmias, ground glass, and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs.Conclusion. Our study further supports the presence of several sex-related differences in patients with SSc. These differences were pronounced in the severity of cutaneous, peripheral vascular, and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterized the female sex.

Published
2022

24. COVID-19 and systemic sclerosis: clinicopathological implications from Italian nationwide survey study

Author

Ferri, Clodoveo, Giuggioli, Dilia, Raimondo, Vincenzo, Dagna, Lorenzo, Riccieri, Valeria, Zanatta, Elisabetta, Guiducci, Serena, Tavoni, Antonio, Foti, Rosario, Cuomo, Giovanna, De Angelis, Rossella, Cozzi, Franco, Murdaca, Giuseppe, Cavazzana, Ilaria, Romeo, Nicoletta, Codullo, Veronica, Ingegnoli, Francesca, Pellegrini, Roberta, Varcasia, Giuseppe, Della Rossa, Alessandra, De Santis, Maria, Abignano, Giuseppina, Colaci, Michele, Caminiti, Maurizio, L'Andolina, Massimo, Lubrano, Ennio, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Bilia, Silvia, Giannini, Daiana, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Dall'Ara, Francesca, Pagano Mariano, Giuseppa, Barsotti, Simone, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Scorpiniti, Daniela, Ferrari, Tommaso, Caminiti, Rodolfo, Campochiaro, Corrado, Cecchetti, Riccardo, Gigliotti, Pietro, Olivo, Domenico, Ursini, Francesco, Brusi, Veronica, Meliconi, Riccardo, Scarpa, Raffaele, Fusaro, Enrico, Zignego, Anna Linda, D'Angelo, Salvatore, Iannone, Florenzo, Matucci-Cerinic, Marco, Doria, Andrea, Miccoli, Mario, Paparo, Sabrina Rosaria, Ragusa, Francesca, Elia, Giusy, Ferrari, Silvia Martina, Fallahi, Poupak, Antonelli, Alessandro, Rossa, Alessandra Della, and Mariano, Giuseppa Pagano

Published
2021
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25. Covid-19 And Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments

Author

Ferri, Clodoveo, primary, Giuggioli, Dilia, additional, Raimondo, Vincenzo, additional, L’Andolina, Massimo, additional, Dagna, Lorenzo, additional, Tavoni, Antonio, additional, Caso, Francesco, additional, Ursini, Francesco, additional, Ruscitti, Piero, additional, Caminiti, Maurizio, additional, Foti, Rosario, additional, Riccieri, Valeria, additional, Guiducci, Serena, additional, Pellegrini, Roberta, additional, Zanatta, Elisabetta, additional, Varcasia, Giuseppe, additional, Olivo, Domenico, additional, Gigliotti, Pietro, additional, Cuomo, Giovanna, additional, Murdaca, Giuseppe, additional, Cecchetti, Riccardo, additional, De Angelis, Rossella, additional, Romeo, Nicoletta, additional, Ingegnoli, Francesca, additional, Cozzi, Franco, additional, Codullo, Veronica, additional, Cavazzana, Ilaria, additional, Colaci, Michele, additional, Abignano, Giuseppina, additional, De Santis, Maria, additional, Lubrano, Ennio, additional, Fusaro, Enrico, additional, Rossa, Alessandra Della, additional, Spinella, Amelia, additional, Lumetti, Federica, additional, De Luca, Giacomo, additional, Bellando-Randone, Silvia, additional, Visalli, Elisa, additional, Dal Bosco, Ylenia, additional, Amato, Giorgio, additional, Giannini, Daiana, additional, Bilia, Silvia, additional, Masini, Francesco, additional, Pellegrino, Greta, additional, Pigatto, Erika, additional, Generali, Elena, additional, Mariano, Giuseppa Pagano, additional, Pettiti, Giorgio, additional, Zanframundo, Giovanni, additional, Brittelli, Raffaele, additional, Aiello, Vincenzo, additional, Caminiti, Rodolfo, additional, Scorpiniti, Daniela, additional, Ferrari, Tommaso, additional, Campochiaro, Corrado, additional, Brusi, Veronica, additional, Fredi, Micaela, additional, Moschetti, Liala, additional, Cacciapaglia, Fabio, additional, Gragnani, Laura, additional, Monti, Monica, additional, Lorini, Serena, additional, Paparo, Sabrina Rosaria, additional, Ragusa, Francesca, additional, Mazzi, Valeria, additional, Elia, Giusy, additional, Ferrari, Silvia Martina, additional, Di Cola, Ilenia, additional, Vadacca, Marta, additional, Lorusso, Sebastiano, additional, Barsotti, Simone, additional, Aprile, Maria Letizia, additional, Marco, Tasso, additional, Miccoli, Mario, additional, Bosello, Silvia, additional, Matucci-Cerinic, Marco, additional, D'Angelo, Salvatore, additional, Doria, Andrea, additional, Franceschini, Franco, additional, Meliconi, Riccardo, additional, Iannone, Florenzo, additional, Giacomelli, Roberto, additional, Zignego, Anna Linda, additional, Fallahi, Poupak, additional, and Antonelli, Alessandro, additional

Published
2021
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26. Cardiovascular outcomes in systemic sclerosis with abnormal cardiovascular MRI and serum cardiac biomarkers

Author

Dumitru, Raluca B, primary, Bissell, Lesley-Anne, additional, Erhayiem, Bara, additional, Kidambi, Ananth, additional, Dumitru, Ana-Maria H, additional, Fent, Graham, additional, Abignano, Giuseppina, additional, Donica, Helena, additional, Burska, Agata, additional, Greenwood, John P, additional, Biglands, John, additional, Schlosshan, Dominik, additional, del Galdo, Francesco, additional, Plein, Sven, additional, and Buch, Maya H, additional

Published
2021
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28. Systemic sclerosis Progression INvestiGation (SPRING) Italian registry: demographic and clinico-serological features of scleroderma spectrum

Author

Ferri, Clodoveo, Giuggioli, Dilia, Guiducci, Serena, Lumetti, Federica, Bajocchi, Gianluigi, Magnani, Luca, Codullo, Veronica, Ariani, Alarico, Girelli, Francesco, Riccieri, Valeria, Pellegrino, Greta, Bosello, Silvia, Foti, Rosario, Visalli, Elisa, Amato, Giorgio, Benenati, Alessia, Cuomo, Giovanna, Iannone, Florenzo, Cacciapaglia, Fabio, Angelis, Rossella, Ingegnoli, Francesca, ROSSELLA TALOTTA, Campochiaro, Corrado, Dagna, Lorenzo, Luca, Giacomo, Bellando-Randone, Silvia, Spinella, Amelia, Murdaca, Giuseppe, Romeo, Nicoletta, Santis, Maria, Generali, Elena, Barsotti, Simone, Della Rossa, Alessandra, Cavazzana, Ilaria, Dall Ara, Francesca, Lazzaroni, Maria G., Cozzi, Franco, Andrea Doria, Pigatto, Erika, ELISABETTA ZANATTA, Ciano, Giovanni, Beretta, Lorenzo, Abignano, Giuseppina, D Angelo, Salvatore, Mennillo, Gianna, Bagnato, Gianluca, Calabrese, Francesca, Caminiti, Maurizio, Pagano Mariano, Giuseppa, Battaglia, Elisabetta, Lubrano, Ennio, Zanframundo, Giovanni, Iuliano, Annamaria, Furini, Federica, Zanetti, Anna, Carrara, Greta, Rumi, Federica, Scirè, Carlo Alberto, Matucci-Cerinic, Marco, Ferri, C, Giuggioli, D, Guiducci, S, Lumetti, F, Bajocchi, G, Magnani, L, Codullo, V, Ariani, A, Girelli, F, Riccieri, V, Pellegrino, G, Bosello, S, Foti, R, Visalli, E, Amato, G, Benenati, A, Cuomo, G, Iannone, F, Cacciapaglia, F, De Angelis, R, Ingegnoli, F, Talotta, R, Campochiaro, C, Dagna, L, De Luca, G, Bellando-Randone, S, Spinella, A, Murdaca, G, Romeo, N, De Santis, M, Generali, E, Barsotti, S, Della Rossa, A, Cavazzana, I, Dall'Ara, F, Lazzaroni, M, Cozzi, F, Doria, A, Pigatto, E, Zanatta, E, Ciano, G, Beretta, L, Abignano, G, D'Angelo, S, Mennillo, G, Bagnato, G, Calabrese, F, Caminiti, M, Pagano Mariano, G, Battaglia, E, Lubrano, E, Zanframundo, G, Iuliano, A, Furini, F, Zanetti, A, Carrara, G, Rumi, F, Scirè, C, Matucci-Cerinic, M, Ferri, Clodoveo, Giuggioli, Dilia, Guiducci, Serena, Lumetti, Federica, Bajocchi, Gianluigi, Magnani, Luca, Codullo, Veronica, Ariani, Alarico, Girelli, Francesco, Riccieri, Valeria, Pellegrino, Greta, Bosello, Silvia, Foti, Rosario, Visalli, Elisa, Amato, Giorgio, Benenati, Alessia, Cuomo, Giovanna, Iannone, Florenzo, Cacciapaglia, Fabio, De Angelis, Rossella, Ingegnoli, Francesca, Talotta, Rossella, Campochiaro, Corrado, Dagna, Lorenzo, De Luca, Giacomo, Bellando-Randone, Silvia, Spinella, Amelia, Murdaca, Giuseppe, Romeo, Nicoletta, De Santis, Maria, Generali, Elena, Barsotti, Simone, Della Rossa, Alessandra, Cavazzana, Ilaria, Dall'Ara, Francesca, Lazzaroni, Maria G, Cozzi, Franco, Doria, Andrea, Pigatto, Erika, Zanatta, Elisabetta, Ciano, Giovanni, Beretta, Lorenzo, Abignano, Giuseppina, D'Angelo, Salvatore, Mennillo, Gianna, Bagnato, Gianluca, Calabrese, Francesca, Caminiti, Maurizio, Pagano Mariano, Giuseppa, Battaglia, Elisabetta, Lubrano, Ennio, Zanframundo, Giovanni, Iuliano, Annamaria, Furini, Federica, Zanetti, Anna, Carrara, Greta, Rumi, Federica, Scirè, Carlo Alberto, and Matucci-Cerinic, Marco

Subjects
Male, Scleroderma, Systemic, Settore MED/16 - REUMATOLOGIA, systemic sclerosis, Raynaud’s phenomenon, VEDOSS, Raynaud Disease, Microscopic Angioscopy, Cohort Studies, Systemic sclerosi, Italy, Humans, Registries, Systemic sclerosis
Abstract

Objectives: Systemic sclerosis (SSc) is a severe multiple-organ disease characterised by unpredictable clinical course, inadequate response to treatment, and poor prognosis. National SSc registries may provide large and representative patients cohorts required for descriptive and prognostic studies. Therefore, the Italian Society for Rheumatology promoted the registry SPRING (Systemic sclerosis Progression INvestiGation). Methods: The SPRING is a multi-centre rheumatological cohort study encompassing the wide scleroderma spectrum, namely the primary Raynaud's phenomenon (pRP), suspected secondary RP, Very Early Diagnosis of Systemic Sclerosis (VEDOSS), and definite SSc. Here we describe the demographic and clinical characteristics of a population of 2,028 Italian patients at the initial phase of enrolment, mainly focusing on the cohort of 1,538 patients with definite SSc. Results: Definite SSc showed a significantly higher prevalence of digital ulcers, capillaroscopic 'late' pattern, oesophageal and cardio-pulmonary involvement compared to VEDOSS, as expected on the basis of the followed classification criteria. The in-depth analysis of definite SSc revealed that male gender, diffuse cutaneous subset, and anti-Scl70 seropositivity were significantly associated with increased prevalence of the most harmful disease manifestations. Similarly, patients with very short RP duration (≤1 year) at SSc diagnosis showed a statistically increased prevalence of unfavourable clinico-serological features. Conclusions: Nationwide registries with suitable subsetting of patients and follow-up studies since the prodromal phase of the disease may give us valuable insights into the SSc natural history and main prognostic factors.

Published
2020

31. Covid-19 And Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments

Author

Ferri, Clodoveo, Giuggioli, Dilia, Raimondo, Vincenzo, L'Andolina, Massimo, Dagna, Lorenzo, Tavoni, Antonio, Caso, Francesco, Ursini, Francesco, Ruscitti, Piero, Caminiti, Maurizio, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Pellegrini, Roberta, Zanatta, Elisabetta, Varcasia, Giuseppe, Olivo, Domenico, Gigliotti, Pietro, Cuomo, Giovanna, Murdaca, Giuseppe, Cecchetti, Riccardo, De Angelis, Rossella, Romeo, Nicoletta, Ingegnoli, Francesca, Cozzi, Franco, Codullo, Veronica, Cavazzana, Ilaria, Colaci, Michele, Abignano, Giuseppina, De Santis, Maria, Lubrano, Ennio, Fusaro, Enrico, Rossa, Alessandra Della, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Dal Bosco, Ylenia, Amato, Giorgio, Giannini, Daiana, Bilia, Silvia, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Mariano, Giuseppa Pagano, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Ferrari, Tommaso, Campochiaro, Corrado, Brusi, Veronica, Fredi, Micaela, Moschetti, Liala, Cacciapaglia, Fabio, Gragnani, Laura, Monti, Monica, Lorini, Serena, Paparo, Sabrina Rosaria, Ragusa, Francesca, Mazzi, Valeria, Elia, Giusy, Ferrari, Silvia Martina, Di Cola, Ilenia, Vadacca, Marta, Lorusso, Sebastiano, Barsotti, Simone, Aprile, Maria Letizia, Marco, Tasso, Miccoli, Mario, Bosello, Silvia Laura, Matucci-Cerinic, Marco, D'Angelo, Salvatore, Doria, Andrea, Franceschini, Franco, Meliconi, Riccardo, Iannone, Florenzo, Giacomelli, Roberto, Zignego, Anna Linda, Fallahi, Poupak, Antonelli, Alessandro, Bosello, Silvia (ORCID:0000-0002-4837-447X), Ferri, Clodoveo, Giuggioli, Dilia, Raimondo, Vincenzo, L'Andolina, Massimo, Dagna, Lorenzo, Tavoni, Antonio, Caso, Francesco, Ursini, Francesco, Ruscitti, Piero, Caminiti, Maurizio, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Pellegrini, Roberta, Zanatta, Elisabetta, Varcasia, Giuseppe, Olivo, Domenico, Gigliotti, Pietro, Cuomo, Giovanna, Murdaca, Giuseppe, Cecchetti, Riccardo, De Angelis, Rossella, Romeo, Nicoletta, Ingegnoli, Francesca, Cozzi, Franco, Codullo, Veronica, Cavazzana, Ilaria, Colaci, Michele, Abignano, Giuseppina, De Santis, Maria, Lubrano, Ennio, Fusaro, Enrico, Rossa, Alessandra Della, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Dal Bosco, Ylenia, Amato, Giorgio, Giannini, Daiana, Bilia, Silvia, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Mariano, Giuseppa Pagano, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Ferrari, Tommaso, Campochiaro, Corrado, Brusi, Veronica, Fredi, Micaela, Moschetti, Liala, Cacciapaglia, Fabio, Gragnani, Laura, Monti, Monica, Lorini, Serena, Paparo, Sabrina Rosaria, Ragusa, Francesca, Mazzi, Valeria, Elia, Giusy, Ferrari, Silvia Martina, Di Cola, Ilenia, Vadacca, Marta, Lorusso, Sebastiano, Barsotti, Simone, Aprile, Maria Letizia, Marco, Tasso, Miccoli, Mario, Bosello, Silvia Laura, Matucci-Cerinic, Marco, D'Angelo, Salvatore, Doria, Andrea, Franceschini, Franco, Meliconi, Riccardo, Iannone, Florenzo, Giacomelli, Roberto, Zignego, Anna Linda, Fallahi, Poupak, Antonelli, Alessandro, and Bosello, Silvia (ORCID:0000-0002-4837-447X)

Abstract

Background: The Covid-19 pandemic may have a deleterious impact on patients with autoimmune systemic diseases (ASD) due to their deep immune-system alterations. Objective: This study aims to investigate the prevalence of symptomatic Covid-19 and its correlations with both organ involvement and ongoing treatments in a large series of Italian ASD patients during the first wave of pandemic. Methods: Our multicenter telephone 6-week survey included 3,029 unselected ASD patients enrolled at 36 tertiary referral centers of northern, central, and southern Italian macro-areas with different diffusion of the pandemic. Symptomatic SARS-CoV-2 infection was classified as definite Covid-19 (presence of symptoms plus positive oral/nasopharyngeal swabs) or highly suspected Covid-19 (highly suggestive symptoms, in the absence of a swab testing). Results: A significantly higher prevalence of definite plus highly suspected Covid-19 compared to the Italian general population was detected in the whole ASD series (p=.000), as well as in patients from the three macro-areas (p=.000 in all). Statistically higher prevalence of Covid-19 was also found in connective tissue diseases compared to chronic arthritis subgroup (p=.000) and in ASD patients with pre-existing interstitial lung involvement (p=.000). Patients treated with either conventional disease-modifying anti-rheumatic drugs (DMARDs) and/or biological DMARDs showed a significantly lower prevalence of Covid-19 (p=.000 in both). Finally, scleroderma patients undergoing low-dose aspirin showed a significantly lower rate of Covid-19 compared to those without (p=0.003). Conclusion: The higher prevalence of Covid-19 in ASD patients, along with the significant correlations with important clinical features and therapeutic regimens, suggests the need to develop targeted prevention/management strategies during the current pandemic wave.

Published
2021

32. Broad clinical spectrum of SARS-CoV-2-associated inflammatory joint disease in adults: a report of 35 cases from the COVID-19 & Autoimmune Systemic Disease Italian study group

Author

Ursini, Francesco, primary, Ruscitti, Piero, additional, D'Angelo, Salvatore, additional, Cacciapaglia, Fabio, additional, De Angelis, Rossella, additional, Campochiaro, Corrado, additional, Caso, Francesco, additional, De Santis, Maria, additional, Di Cola, Ilenia, additional, Parisi, Simone, additional, Raimondo, Vincenzo, additional, Abignano, Giuseppina, additional, Costa, Luisa, additional, Ciaffi, Jacopo, additional, Dagna, Lorenzo, additional, Iagnocco, Annamaria, additional, Iannone, Florenzo, additional, Meliconi, Riccardo, additional, Giacomelli, Roberto, additional, and Ferri, Clodoveo, additional

Published
2021
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33. The PREdictor of MAlnutrition in Systemic Sclerosis (PREMASS) Score: A Combined Index to Predict 12 Months Onset of Malnutrition in Systemic Sclerosis

Author

Bagnato, Gianluca, primary, Pigatto, Erika, additional, Bitto, Alessandra, additional, Pizzino, Gabriele, additional, Irrera, Natasha, additional, Abignano, Giuseppina, additional, Ferrera, Antonino, additional, Sciortino, Davide, additional, Wilson, Michelle, additional, Squadrito, Francesco, additional, Buch, Maya H., additional, Emery, Paul, additional, Zanatta, Elisabetta, additional, Gangemi, Sebastiano, additional, Saitta, Antonino, additional, Cozzi, Franco, additional, Roberts, William Neal, additional, and Del Galdo, Francesco, additional

Published
2021
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38. UCLA Scleroderma Clinical Trials Consortium Gastrointestinal Tract (GIT) 2.0 Reflux Scale Correlates With Impaired Esophageal Scintigraphy Findings in Systemic Sclerosis

Author

Abignano, Giuseppina, primary, Mennillo, Gianna Angela, additional, Lettieri, Giovanni, additional, Karadag, Duygu Temiz, additional, Carriero, Antonio, additional, Padula, Angela Anna, additional, Del Galdo, Francesco, additional, Khanna, Dinesh, additional, and D’Angelo, Salvatore, additional

Published
2021
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42. Predictors of subclinical systemic sclerosis primary heart involvement characterised by microvasculopathy and myocardial fibrosis

Author

Dumitru, Raluca B, primary, Bissell, Lesley-Anne, additional, Erhayiem, Bara, additional, Fent, Graham, additional, Kidambi, Ananth, additional, Swoboda, Peter, additional, Abignano, Giuseppina, additional, Donica, Helena, additional, Burska, Agata, additional, Greenwood, John P, additional, Biglands, John, additional, Del Galdo, Francesco, additional, Plein, Sven, additional, and Buch, Maya H, additional

Published
2020
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43. Anti-vinculin antibodies in scleroderma (SSc): a potential link between autoimmunity and gastrointestinal system involvement in two SSc cohorts

Author

Suliman, Yossra, primary, Kafaja, Suzanne, additional, Oh, Sunny J., additional, Alemam, Mohamed, additional, Bagnato, Gianluca, additional, Abignano, Giuseppina, additional, Singh, Ram Raj, additional, Barlow, Gillian, additional, Liu, Xiaochen, additional, Valera, Isela, additional, Morales, Walter, additional, Rezaie, Ali, additional, Pimentel, Mark, additional, Del Galdo, Francesco, additional, and Furst, Daniel E, additional

Published
2020
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44. Incidence, prevalence and mortality of systemic sclerosis in Italy: a nationwide population-based study using administrative health data

Author

Ciaffi, Jacopo, primary, Morabito, Maria Francesca, additional, Ruscitti, Piero, additional, D’Angelo, Salvatore, additional, Mancarella, Luana, additional, Brusi, Veronica, additional, Abignano, Giuseppina, additional, Pucino, Valentina, additional, Giacomelli, Roberto, additional, Meliconi, Riccardo, additional, and Ursini, Francesco, additional

Published
2020
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49. P162 Cross-validation and complementary value of optical coherence tomography and high frequency ultrasound for the assessment of skin disease in systemic sclerosis

Author

Karadag, Duygu Temiz, primary, Lettieri, Giovanni, primary, Picerno, Valentina, primary, Gundogdu, Ozcan, primary, Padula, Maria Carmela, primary, Mennillo, Gianna A, primary, Padula, Angela A, primary, Galdo, Francesco Del, primary, D'Angelo, Salvatore, primary, and Abignano, Giuseppina, primary

Published
2020
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