Search

Your search keyword '"Ablonczy, László"' showing total 43 results
Start Over Author "Ablonczy, László"
43 results on '"Ablonczy, László"'

4. The First 5 Years of the Newest Eurotransplant Member State: Hungarian Results of International Organ Exchange From 2014 to 2018

Author

Mihály, Sándor, Smudla, Anikó, Ablonczy, László, Kóbori, László, Nemes, Balázs, Rényi-Vámos, Ferenc, Szabolcs, Zoltán, Szakály, Péter, Kalmár Nagy, Károly, Szederkényi, Edit, Auer, Brigitta, Deme, Orsolya, Egyed-Varga, Anita, Holtzinger, Emese, Vida-Mező, Anikó, Nacsa, János, Szilvási, Anikó, and Merkely, Béla

Published
2021
Full Text
View/download PDF

5. Clinical characteristics and outcomes of patients with adult congenital heart disease listed for heart and heart‒lung transplantation in the Eurotransplant region

Author

Becher, Peter Moritz, Schrage, Benedikt, Weimann, Jessica, Smits, Jacqueline, Magnussen, Christina, Reichenspurner, Hermann, Goßling, Alina, Rodrigus, Inez, Dumfarth, Julia, de Pauw, Michel, François, Katrien, van Caenegem, Olivier, Ancion, Arnaut, Van Cleemput, Johan, Milicic, Davor, Moza, Ajay, Schenker, Peter, Röhrich, Luise, Schönrath, Felix, Thul, Josef, Steinmetz, Michael, Schmack, Bastian, Ruhparwar, Arjang, Warnecke, Gregor, Rojas, Sebastian V., Sandhaus, Tim, Haneya, Assad, Eifert, Sandra, Welp, Henryk, Ablonczy, László, Wagner, Florian, Westermann, Dirk, Bernhardt, Alexander M., Knappe, Dorit, Blankenberg, Stefan, Kirchhof, Paulus, Zengin, Elvin, and Sinning, Christoph

Published
2020
Full Text
View/download PDF

6. Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study

Author

Bajcetic, Milica, de Wildt, Saskia N., Dalinghaus, Michiel, Breitkreutz, Jörg, Klingmann, Ingrid, Lagler, Florian B., Keatley-Clarke, Anne, Breur, Johannes MPJ., Male, Christoph, Jovanovic, Ida, Szatmári, Andras, Ablonczy, László, Burckhardt, Bjoern B., Cawello, Willi, Kleine, Karl, Obarcanin, Emina, Spatenkova, Lucie, Swoboda, Vanessa, van der Meulen, Marijke, Wagner, Peter, Walsh, Jennifer, and Läer, Stephanie

Published
2019
Full Text
View/download PDF

9. Újdonságok a gyermekkori katéter-intervenciós terápiában.

Author

Ablonczy, László and Környei, László

Abstract

Copyright of Gyermekgyógyászat is the property of Semmelweis Kiado and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

10. Coarctatio aortae az újszülöttkoron túl -- felismerés és kezelési stratégiák.

Author

Lorencz, Péter, Ablonczy, László, and Kis, Éva

Abstract

Copyright of Gyermekgyógyászat is the property of Semmelweis Kiado and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

11. Szöveti plazminogén aktivátor használatával szerzett tapasztalataink a Gottsegen György Országos Kardiovascularis Intézet Gyermekszív Központjában.

Author

Simon, Gábor, Pongrácz, Brigitta, and Ablonczy, László

Abstract

Copyright of Gyermekgyógyászat is the property of Semmelweis Kiado and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

12. Képalkotó vizsgálatok helye a gyermekkardiológiai intervenciók tervezésében.

Author

Kis, Éva and Ablonczy, László

Abstract

Copyright of Gyermekgyógyászat is the property of Semmelweis Kiado and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

14. Edoxaban for Thromboembolism Prevention in Pediatric Patients With Cardiac Disease

Author

Portman, Michael A., primary, Jacobs, Jeffrey P., additional, Newburger, Jane W., additional, Berger, Felix, additional, Grosso, Michael A., additional, Duggal, Anil, additional, Tao, Ben, additional, Goldenberg, Neil A., additional, Brothers, Matthew, additional, Marino, Bradley, additional, Canter, Charles, additional, Law, Mark, additional, Nguyen, Nguyenvu, additional, Sang, Charlie, additional, Shimano, Kristin, additional, Gupta, Dipankar, additional, Portman, Michael, additional, Williams, Derek, additional, Glass, Lauren, additional, Sperrazza, Charles, additional, Herold, Steven, additional, Garg, Ruchira, additional, Vranicar, Mark, additional, Awad, Sawsan, additional, Asante-Korang, Alfred, additional, Druzgal, Colleen, additional, Ozment, Caroline, additional, Del Toro, Kamill, additional, Roses, Ferran, additional, Jux, Christian, additional, Gravenhorst, Verena, additional, Schweigmann, Ulrich, additional, Bhatt, Mihir, additional, Sabapathy, Christine, additional, Dahdah, Nagib, additional, Bartonicek, Dototea, additional, Tulzer, Gerald, additional, Basargina, Elena, additional, Zvereva, Tatiana, additional, Pertels, Tatiana, additional, Plotnikova, Irina, additional, Pierre-Emmanuel, S.E.G.U.E.L.A., additional, Amedro, Pascal, additional, Yves, Dulac, additional, BONNET, Damien, additional, Saraco, Paola, additional, Rimini, Alessandro, additional, Digtiar, Valerii, additional, Gonchar, Margaryta, additional, Kryuchko, Tetyana, additional, Yablon, Olga, additional, Bedi, Varinder Singh, additional, Patel, Jashvant, additional, Mitra, Monjori, additional, Kusa, Jacek, additional, Domagala, Kowalczyk, additional, KÖRNYEI, László, additional, BERECZKI, Csaba, additional, ABLONCZY, László, additional, Levitas, Vivianne Aviva, additional, Mishali, David, additional, Revel-Vilk, Shoshana, additional, Harlev, Dan, additional, Sasmaz, Hatice Ilgen, additional, Ozbek, Namik Yasar, additional, Unal, Sule, additional, Patıroglu, Türkan, additional, Malbora, Baris, additional, Agin, Hasan, additional, Karakas, Zeynep, additional, Kavakli, Ramazan Kaan, additional, Chalmers, Elizabeth, additional, Bu'Lock, Frances, additional, Daubeney, Piers, additional, Hamza, Hala, additional, Badr, Mohamed, additional, Elalfy, Mohsen, additional, Mansour, Ahmed, additional, Hassab, Hoda, additional, Sabry, Ayman, additional, Daou, Linda, additional, and Bitar, Fadi, additional

Published
2022
Full Text
View/download PDF

15. Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)

Author

Laeer, Stephanie, primary, Cawello, Willi, additional, Burckhardt, Bjoern B., additional, Ablonczy, László, additional, Bajcetic, Milica, additional, Breur, Johannes M. P. J., additional, Dalinghaus, Michiel, additional, Male, Christoph, additional, de Wildt, Saskia N., additional, Breitkreutz, Jörg, additional, Faisal, Muhammed, additional, Keatley-Clarke, Anne, additional, Klingmann, Ingrid, additional, and Lagler, Florian B., additional

Published
2022
Full Text
View/download PDF

16. Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)

Author

Laeer, Stephanie, Cawello, Willi, Burckhardt, Bjoern B., Ablonczy, László, Bajcetic, Milica, Breur, Johannes M.P.J., Dalinghaus, Michiel, Male, Christoph, de Wildt, Saskia N., Breitkreutz, Jörg, Faisal, Muhammed, Keatley-Clarke, Anne, Klingmann, Ingrid, Lagler, Florian B., Laeer, Stephanie, Cawello, Willi, Burckhardt, Bjoern B., Ablonczy, László, Bajcetic, Milica, Breur, Johannes M.P.J., Dalinghaus, Michiel, Male, Christoph, de Wildt, Saskia N., Breitkreutz, Jörg, Faisal, Muhammed, Keatley-Clarke, Anne, Klingmann, Ingrid, and Lagler, Florian B.

Abstract

Angiotensin-converting enzyme inhibitors (ACEI), such as enalapril, are a cornerstone of treatment for pediatric heart failure which is still used off-label. Using a novel age-appropriate formulation of enalapril orodispersible minitablets (ODMTs), phase II/III open-label, multicenter pharmacokinetic (PK) bridging studies were performed in pediatric patients with heart failure due to dilated cardiomyopathy (DCM) and congenital heart disease (CHD) in five participating European countries. Children were treated for 8 weeks with ODMTs according to an age-appropriate dosing schedule. The primary objective was to describe PK parameters (area under the curve (AUC), maximal concentration (Cmax), time to reach maximal concentration (t-max)) of enalapril and its active metabolite enalaprilat. Of 102 patients, 89 patients (n = 26, DCM; n = 63 CHD) were included in the primary PK endpoint analysis. Rate and extent of enalapril and its active metabolite enalaprilat were described and etiology and age could be identified as potential PK modifying factors. The dosing schedule appeared to be tolerated well and did not result in any significant drug-related serious adverse events. The PK analysis and the lack of severe safety events supports the applied age-appropriate dosing schedule for the enalapril ODMTs.

Published
2022

17. Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Laeer, Stephanie, Cawello, Willi, Burckhardt, Bjoern B, Ablonczy, László, Bajcetic, Milica, Breur, Johannes M P J, Dalinghaus, Michiel, Male, Christoph, de Wildt, Saskia N, Breitkreutz, Jörg, Faisal, Muhammed, Keatley-Clarke, Anne, Klingmann, Ingrid, Lagler, Florian B, Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Laeer, Stephanie, Cawello, Willi, Burckhardt, Bjoern B, Ablonczy, László, Bajcetic, Milica, Breur, Johannes M P J, Dalinghaus, Michiel, Male, Christoph, de Wildt, Saskia N, Breitkreutz, Jörg, Faisal, Muhammed, Keatley-Clarke, Anne, Klingmann, Ingrid, and Lagler, Florian B

Published
2022

18. Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA‐R)

Author

Sinning, Christoph, Zengin, Elvin, Diller, Gerhard-Paul, Onorati, Francesco, Castel, María-Angeles, Petit, Thibault, Chen, Yih-Sharng, Lo Rito, Mauro, Chiarello, Carmelina, Guillemain, Romain, Coniat, Karine Nubret-Le, Magnussen, Christina, Knappe, Dorit, Becher, Peter Moritz, Schrage, Benedikt, Smits, Jacqueline M., Metzner, Andreas, Knosalla, Christoph, Schoenrath, Felix, Miera, Oliver, Cho, Mi-Young, Bernhardt, Alexander, Weimann, Jessica, Goßling, Alina, Terzi, Amedeo, Amodeo, Antonio, Alfieri, Sara, Angeli, Emanuela, Ragni, Luca, Napoleone, Carlo Pace, Gerosa, Gino, Pradegan, Nicola, Rodrigus, Inez, Dumfarth, Julia, de Pauw, Michel, François, Katrien, Van Caenegem, Olivier, Ancion, Arnaut, Van Cleemput, Johan, Miličić, Davor, Moza, Ajay, Schenker, Peter, Thul, Josef, Steinmetz, Michael, Warnecke, Gregor, Ius, Fabio, Freyt, Susanne, Avsar, Murat, Sandhaus, Tim, Haneya, Assad, Eifert, Sandra, Saeed, Diyar, Borger, Michael, Welp, Henryk, Ablonczy, László, Schmack, Bastian, Ruhparwar, Arjang, Naito, Shiho, Hua, Xiaoqin, Fluschnik, Nina, Nies, Moritz, Keil, Laura, Senftinger, Juliana, Ismaili, Djemail, Kany, Shinwan, Csengeri, Dora, Cardillo, Massimo, Oliveti, Alessandra, Faggian, Giuseppe, Dorent, Richard, Jasseron, Carine, Blanco, Alicia Pérez, Márquez, José Manuel Sobrino, López-Vilella, Raquel, García-Álvarez, Ana, López, María Luz Polo, Rocafort, Alvaro Gonzalez, Fernández, Óscar González, Prieto-Arevalo, Raquel, Zatarain-Nicolás, Eduardo, Blanchart, Katrien, Boignard, Aude, Battistella, Pascal, Guendouz, Soulef, Houyel, Lucile, Para, Marylou, Flecher, Erwan, Gay, Arnaud, Épailly, Éric, Dambrin, Camille, Lam, Kaitlyn, Ka-lai, Cally Ho, Cho, Yang Hyun, Choi, Jin-Oh, Kim, Jae-Joong, Coats, Louise, Crossland, David Steven, Mumford, Lisa, Hakmi, Samer, Sivathasan, Cumaraswamy, Fabritz, Larissa, Schubert, Stephan, Gummert, Jan, Hübler, Michael, Jacksch, Peter, Zuckermann, Andreas, Laufer, Günther, Baumgartner, Helmut, Giamberti, Alessandro, Reichenspurner, Hermann, and Kirchhof, Paulus

Subjects
Heart Defects, Congenital, Adult, Cardiac & Cardiovascular Systems, Heart Defects, Congenital / therapy, Waiting Lists, Study Designs, Medizin, Heart transplantation, Heart Defects, Congenital / complications, MANAGEMENT, Diseases of the circulatory (Cardiovascular) system, Humans, ESC GUIDELINES, Heart Failure / therapy, Adults with congenital heart disease, Arrhythmia, Heart failure, Heart transplantation, Lung transplantation, Ventricular assist device, Retrospective Studies, GENERAL-POPULATION, Heart Failure, OUTCOMES, Study Design, Science & Technology, TRANSPLANTATION, MORTALITY, Heart Failure / epidemiology, Heart Transplantation / adverse effects, ADULTS, ASSOCIATION, EUROPEAN-SOCIETY, Lung transplantation, Heart Failure / etiology, RC666-701, Cardiovascular System & Cardiology, Ventricular assist device, Heart Transplantation, Heart Defects, Congenital / epidemiology, Adults with congenital heart disease, Human medicine, Life Sciences & Biomedicine, Arrhythmia, TASK-FORCE
Abstract

ESC heart failure 8(6), 5542-5550 (2021). doi:10.1002/ehf2.13574, Published by Wiley, Chichester

Published
2021
Full Text
View/download PDF

20. A gyermekkori koronavírus-fertőzést követő sokszervi gyulladás diagnosztikája és kezelése

Author

Constantin, Tamás, primary, Andrási, Noémi, additional, Ponyi, Andrea, additional, Goschler, Ádám, additional, Ablonczy, László, additional, Kincs, Judit, additional, Csóka, Monika, additional, Egyed, Bálint, additional, Horváth, Zsuzsanna, additional, Kalocsai, Krisztina, additional, Káposzta, Rita, additional, Kardics, Kinga, additional, Kemény, Viktória, additional, Mosdósi, Bernadett, additional, Pék, Tamás, additional, Szabó, Zsófia, additional, Tóth, Attila, additional, Tory, Kálmán, additional, Tölgyesi, Andrea, additional, Ónozó, Beáta, additional, Vágó, Hajnalka, additional, Vilmányi, Csaba, additional, Peter, Weiser, additional, Szekanecz, Zoltán, additional, Kovács, Gábor, additional, and Szabó, Attila, additional

Published
2021
Full Text
View/download PDF

21. Simulation Training to Improve Informed Consent and Pharmacokinetic/Pharmacodynamic Sampling in Pediatric Trials

Author

Burckhardt, Bjoern B., primary, Ciplea, Agnes Maria, additional, Laven, Anna, additional, Ablonczy, László, additional, Klingmann, Ingrid, additional, Läer, Stephanie, additional, Kleine, Karl, additional, Dalinghaus, Michiel, additional, Đukić, Milan, additional, Breur, Johannes M. P. J., additional, van der Meulen, Marijke, additional, Swoboda, Vanessa, additional, Schwender, Holger, additional, and Lagler, Florian B., additional

Published
2020
Full Text
View/download PDF

23. ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation

Author

Kirk, Richard, primary, Dipchand, Anne I., additional, Davies, Ryan R., additional, Miera, Oliver, additional, Chapman, Gretchen, additional, Conway, Jennifer, additional, Denfield, Susan, additional, Gossett, Jeffrey G., additional, Johnson, Jonathan, additional, McCulloch, Michael, additional, Schweiger, Martin, additional, Zimpfer, Daniel, additional, Ablonczy, László, additional, Adachi, Iki, additional, Albert, Dimpna, additional, Alexander, Peta, additional, Amdani, Shahnawaz, additional, Amodeo, Antonio, additional, Azeka, Estela, additional, Ballweg, Jean, additional, Beasley, Gary, additional, Böhmer, Jens, additional, Butler, Alison, additional, Camino, Manuela, additional, Castro, Javier, additional, Chen, Sharon, additional, Chrisant, Maryanne, additional, Christen, Urs, additional, Danziger-Isakov, Lara, additional, Das, Bibhuti, additional, Everitt, Melanie, additional, Feingold, Brian, additional, Fenton, Matthew, additional, Garcia-Guereta, Luis, additional, Godown, Justin, additional, Gupta, Dipankar, additional, Irving, Claire, additional, Joong, Anna, additional, Kemna, Mariska, additional, Khulbey, Sanjeev Kumar, additional, Kindel, Steven, additional, Knecht, Kenneth, additional, Lal, Ashwin K., additional, Lin, Kimberly, additional, Lord, Karen, additional, Möller, Thomas, additional, Nandi, Deipanjan, additional, Niesse, Oliver, additional, Peng, David M., additional, Pérez-Blanco, Alicia, additional, Punnoose, Ann, additional, Reinhardt, Zdenka, additional, Rosenthal, David, additional, Scales, Angie, additional, Scheel, Janet, additional, Shih, Renata, additional, Smith, Jonathan, additional, Smits, Jacqueline, additional, Thul, Josef, additional, Weintraub, Robert, additional, Zangwill, Steve, additional, and Zuckerman, Warren A., additional

Published
2020
Full Text
View/download PDF

24. Clinical characteristics and outcomes of patients with adult congenital heart disease listed for heart and heart‒lung transplantation in the Eurotransplant region.

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Becher, Peter Moritz, Schrage, Benedikt, Weimann, Jessica, Smits, Jacqueline, Magnussen, Christina, Reichenspurner, Hermann, Goßling, Alina, Rodrigus, Inez, Dumfarth, Julia, de Pauw, Michel, François, Katrien, Van Caenegem, Olivier, Ancion, Arnaut, Van Cleemput, Johan, Milicic, Davor, Moza, Ajay, Schenker, Peter, Röhrich, Luise, Schönrath, Felix, Thul, Josef, Steinmetz, Michael, Schmack, Bastian, Ruhparwar, Arjang, Warnecke, Gregor, Rojas, Sebastian V, Sandhaus, Tim, Haneya, Assad, Eifert, Sandra, Welp, Henryk, Ablonczy, László, Wagner, Florian, Westermann, Dirk, Bernhardt, Alexander M, Knappe, Dorit, Blankenberg, Stefan, Kirchhof, Paulus, Zengin, Elvin, Sinning, Christoph, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Becher, Peter Moritz, Schrage, Benedikt, Weimann, Jessica, Smits, Jacqueline, Magnussen, Christina, Reichenspurner, Hermann, Goßling, Alina, Rodrigus, Inez, Dumfarth, Julia, de Pauw, Michel, François, Katrien, Van Caenegem, Olivier, Ancion, Arnaut, Van Cleemput, Johan, Milicic, Davor, Moza, Ajay, Schenker, Peter, Röhrich, Luise, Schönrath, Felix, Thul, Josef, Steinmetz, Michael, Schmack, Bastian, Ruhparwar, Arjang, Warnecke, Gregor, Rojas, Sebastian V, Sandhaus, Tim, Haneya, Assad, Eifert, Sandra, Welp, Henryk, Ablonczy, László, Wagner, Florian, Westermann, Dirk, Bernhardt, Alexander M, Knappe, Dorit, Blankenberg, Stefan, Kirchhof, Paulus, Zengin, Elvin, and Sinning, Christoph

Abstract

BACKGROUND: The therapeutic success in patients with congenital heart disease (CHD) leads to a growing number of adults with CHD (adult CHD [ACHD]) who develop end-stage heart failure. We aimed to determine patient characteristics and outcomes of ACHD listed for heart transplantation. METHODS: Using data from all the patients with ACHD in 20 transplant centers in the Eurotransplant region from 1999 to 2015, we analyzed patient characteristics, waiting list, and post-transplantation outcomes. RESULTS: A total of 204 patients with ACHD were listed during the study period. The median age was 38 years, and 62.3% of the patients were listed in high urgency (HU), and 37.7% of the patients were in transplantable (T)-listing status. A total of 23.5% of the patients died or were delisted owing to clinical worsening, and 75% of the patients underwent transplantation. Median waiting time for patients with HU-listing status was 4.18 months and with T-listing status 9.07 months. There was no difference in crude mortality or delisting between patients who were HU status listed and T status listed (p = 0.65). In multivariable regression analysis, markers for respiratory failure (mechanical ventilation, hazard ratio [HR]: 1.41, 95% CI: 1.11-1.81, p = 0.006) and arrhythmias (anti-arrhythmic medication, HR: 1.42, 95% CI: 1.01-2.01, p = 0.044) were associated with a higher risk of death or delisting. In the overall cohort, post-transplantation mortality was 26.8% after 1 year and 33.4% after 5 years. CONCLUSIONS: Listed patients are at high risk of death without differences in the urgency of listing. Respiratory failure requiring invasive ventilation and possibly arrhythmias requiring anti-arrhythmic medication indicate worse outcomes on waiting list.

Published
2020

25. Simulation Training to Improve Informed Consent and Pharmacokinetic/Pharmacodynamic Sampling in Pediatric Trials

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Burckhardt, Bjoern B., Ciplea, Agnes Maria, Laven, Anna, Ablonczy, László, Klingmann, Ingrid, Läer, Stephanie, Kleine, Karl, Dalinghaus, Michiel, Đukić, Milan, Breur, Johannes M.P.J., van der Meulen, Marijke, Swoboda, Vanessa, Schwender, Holger, Lagler, Florian B., Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, Burckhardt, Bjoern B., Ciplea, Agnes Maria, Laven, Anna, Ablonczy, László, Klingmann, Ingrid, Läer, Stephanie, Kleine, Karl, Dalinghaus, Michiel, Đukić, Milan, Breur, Johannes M.P.J., van der Meulen, Marijke, Swoboda, Vanessa, Schwender, Holger, and Lagler, Florian B.

Published
2020

27. Pharmacotherapeutic management of paediatric heart failure and ACE-I use patterns: a European survey

Author

Castro Díez, Cristina, primary, Khalil, Feras, additional, Schwender, Holger, additional, Dalinghaus, Michiel, additional, Jovanovic, Ida, additional, Makowski, Nina, additional, Male, Christoph, additional, Bajcetic, Milica, additional, van der Meulen, Marijke, additional, de Wildt, Saskia N, additional, Ablonczy, László, additional, Szatmári, András, additional, Klingmann, Ingrid, additional, Walsh, Jennifer, additional, and Läer, Stephanie, additional

Published
2019
Full Text
View/download PDF

32. Use of subcutaneous treprostinil in pediatric pulmonary arterial hypertension—Bridge‐to‐transplant or long‐term treatment?

Author

Ablonczy, László, Tordas, Dániel, Kis, Eva, and Szatmári, András

Subjects
*LUNG transplantation, *PULMONARY artery, *HYPERTENSION, *PROSTACYCLIN, *THROMBOEMBOLISM in children, *THERAPEUTICS
Abstract

Abstract: PAH is a progressive life‐threatening disease in children. While parenteral prostacyclin therapy improves survival in patients with severe PAH, central line‐related complications are common. Our aim was to assess the efficacy, safety, and tolerability of subcutaneous treprostinil treatment in pediatric PAH patients. Eight patients were treated with subcutaneous treprostinil at the Pediatric Heart Center Budapest. Indications for subcutaneous treprostinil therapy were clinical worsening and/or echocardiographic progression or switch from intravenous to subcutaneous therapy. Following treprostinil initiation, clinical status improved or did not change in four of eight patients. Two patients were lost early during treprostinil therapy, parenteral treprostinil as a rescue therapy being insufficient in these cases. The final dose in long‐term treated patients was between 60 and 100 ng/kg/min. Aside from thrombocytopenia, other severe side effects were not observed. Potts shunt was performed as palliative treatment in two cases. Three patients had successful lung transplantation, and one died while on the waiting list. Long‐term subcutaneous treprostinil could be a safe and well‐tolerated therapy in children with severe PAH even at higher doses. It may serve as an alternative to intravenous prostacyclin treatment allowing to avoid the potential complications of permanent central line placement. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

39. Diagnosis and treatment of paediatric multisystem inflammatory syndrome

Author

Constantin T, Andrási N, Ponyi A, Goschler Á, Ablonczy L, Kincs J, Csóka M, Egyed B, Horváth Z, Kalocsai K, Káposzta R, Kardics K, Kemény V, Mosdósi B, Pék T, Szabó Z, Tóth A, Tory K, Tölgyesi A, Ónozó B, Vágó H, Vilmányi C, Peter W, Szekanecz Z, Kovács G, and Szabó A

Subjects
Algorithms, Child, Critical Care, Humans, COVID-19 complications, COVID-19 diagnosis, COVID-19 therapy, COVID-19 virology, Systemic Inflammatory Response Syndrome diagnosis, Systemic Inflammatory Response Syndrome therapy, Systemic Inflammatory Response Syndrome virology
Abstract

Összefoglaló. A SARS-CoV-2-fertőzés ritka gyermekkori szövődménye a sokszervi gyulladás, angol terminológiával paediatric inflammatory multisystem syndrome (PIMS). Két vagy több szerv érintettségével járó, súlyos tünetekkel induló betegségről van szó, amelynek tünetei átfedést mutatnak a Kawasaki-betegséggel, a toxikus sokk szindrómával és a makrofágaktivációs szindrómával. A PIMS-betegek intenzív terápiás osztályon vagy intenzív terápiás háttérrel rendelkező intézményben kezelendők, ahol biztosítottak a kardiológiai ellátás feltételei is. A szükséges immunterápia a klinikai prezentációtól függ. A jelen közleményben a szerzők a releváns nemzetközi irodalom áttekintését követően ajánlást tesznek a PIMS diagnosztikai és terápiás algoritmusára. Orv Hetil. 2021; 162(17): 652-667. Summary. Pediatric inflammatory multisystem syndrome (PIMS) is a rare complication of SARS-CoV-2 infection in children. PIMS is a severe condition, involving two or more organ systems. The symptoms overlap with Kawasaki disease, toxic shock syndrome and macrophage activation syndrome. PIMS patients should be treated in an intensive care unit or in an institution with an intensive care background, where cardiological care is also provided. The required specific immunotherapy depends on the clinical presentation. In this paper, after reviewing the relevant international literature, the authors make a recommendation for the diagnostic and therapeutic algorithm for PIMS. Orv Hetil. 2021; 162(17): 652-667.

Published
2021
Full Text
View/download PDF

41. [Role of the Ross-procedure in the management of congenital heart defects].

Author

Hartyánszky I, Kollár A, Kádár K, Ablonczy L, Novák E, and Tóth A

Subjects
Adolescent, Child, Child, Preschool, Female, Heart Defects, Congenital mortality, Heart Defects, Congenital physiopathology, Heart Valve Prosthesis, Humans, Infant, Male, Pulmonary Valve transplantation, Reoperation, Transplantation, Autologous, Transplantation, Homologous, Treatment Outcome, Ventricular Outflow Obstruction surgery, Young Adult, Aortic Valve surgery, Cardiac Surgical Procedures methods, Cardiac Surgical Procedures mortality, Heart Defects, Congenital surgery, Heart Valve Prosthesis Implantation, Hemodynamics, Mitral Valve surgery, Pulmonary Valve surgery
Abstract

Introduction: The surgical strategy to manage multilevel left ventricular outflow tract diseases is changing constantly, however, the Ross-procedure has remained a standard method for 45 years., Aim: The aim of the study was to analyze early and mid-term results of Ross-procedure in congenital heart defects (single surgeon's results)., Methods: From 2001 until 2011 a total of 63 patients (age, 28 days-21 years; mean: 10 years, weight 3.4-96 kg; mean, 8.8 kg) underwent Ross (n = 40), Ross-Konno (n = 17) or Ross-Konno-mitral (n = 6) procedures. Indication for Ross procedure was aortic regurgitation in 15 patients (associated with ventricular septum defect in 8 patients) and a predominant aortic stenosis in 25 patients. 17 patients with severe left ventricular outflow tract obstruction underwent Ross-Konno procedure. 6 patients with concomitant mitral valve disease (Shone syndrome, 3 patients; complete atrioventricular septal defect, 3 patients) were reconstructed by Ross-Konno-mitral valve procedure., Results: Among Ross patients there were one early (cerebral complication) and one late death (homograft endocarditis) with a mean follow-up time of 7.4±1.8 years. Because of an early autograft endocarditis a 3-year-old boy underwent homograft implantation and was treated successfully with Bentall-procedure 9 years later. One patient with autograft regurgitation is waiting for reoperation. Among Ross-Konno patients there was no early or late death, and none of the patients underwent reoperation. In Ross-Konno-mitral patients there was one early death (28-day-old boy) and during a mean follow-up time of 2.5±1 years, and no reintervention or reoperation was needed in 5 patients., Conclusions: The results indicate a good outcome of Ross-, Ross-Konno-, Ross-Konno-mitral procedures in patients with congenital heart defects when surgery is performed by a highly experienced heart surgeon. In newborns, infants and small children Ross- and Ross-Konno procedures are the only methods for managing left ventricular outflow tract diseases. Concomitant severe mitral disease adds a high level of technical complexity to the Ross-Konno/mitral procedure, but it should be balanced against alternative strategies (eg. single ventricle palliation or transplantation).

Published
2013
Full Text
View/download PDF

42. [Redo procedures for correction of aortic valve diseases in infants and children. The Bentall-Konno procedure].

Author

Hartyánszky I, Kollár A, Kassai I, Székely E, Ablonczy L, Kádár K, and Szatmári A

Subjects
Adolescent, Aortic Valve Insufficiency pathology, Aortic Valve Stenosis pathology, Catheterization, Child, Child, Preschool, Humans, Infant, Reoperation, Transplantation, Autologous, Transplantation, Homologous, Vascular Surgical Procedures methods, Aortic Valve Insufficiency surgery, Aortic Valve Stenosis surgery, Heart Valve Prosthesis Implantation methods
Abstract

On an infant with critical valvular aortic stenosis balloon-valvoplasty, and 3 years later because of the aortic valve regurgitation Ross operation was performed. In the early postoperative period an aortic-root abscess occurred due to an infective endocarditis; the aortic root was corrected by homograft implantation. Due to a relatively small, calcified aortic valve, with aortic valve regurgitation grade III at the age of 12 years, a Bentall-Konno procedure was performed successfully. This is the first case when this complex surgical procedure was performed successfully on a child in Hungary.

Published
2010
Full Text
View/download PDF

43. [Role of heart transplantation in pediatric heart surgery. The first successful pediatric heart transplantation in Hungary].

Author

Hartyánszky I, Ablonczy L, Bodor E, Hartyánszky I Jr, Bodor G, Mihályi S, Sápi E, Héthársi B, and Szatmári A

Subjects
Child, Humans, Hungary, Male, Cardiomyopathy, Dilated surgery, Heart Transplantation methods
Abstract

7-year-old boy, who underwent aortic valve replacement two years previously, suffered from idiopathic dilated cardiomyopathy. Because of poor condition (NYHA-IV), heart transplantation was performed on 18th October 2007. It was the first pediatric heart transplantation in Hungary. It was an uneventful early postoperative period, 6 months after the operation he is doing well, no biopsy-proven and tissue Doppler echocardiography (TDI-derived velocities measurement) rejection was detected. The immunosuppression was based on triple-drug therapy (tacrolimus+mycophenolate mofetil+corticosteroid) with use of induction therapy with interleukin-2 receptor blocker (basiliximab).

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results