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The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period. It has collected 1228 multimodal magnetic resonance imaging (MRI) brain datasets from 1173 fetal and/or neonatal participants, together with collateral demographic, clinical, family, neurocognitive and genomic data from 1173 participants, together with collateral demographic, clinical, family, neurocognitive and genomic data. All subjects were studied in utero and/or soon after birth on a single MRI scanner using specially developed scanning sequences which included novel motion-tolerant imaging methods. Imaging data are complemented by rich demographic, clinical, neurodevelopmental, and genomic information. The project is now releasing a large set of neonatal data; fetal data will be described and released separately. This release includes scans from 783 infants of whom: 583 were healthy infants born at term; as well as preterm infants; and infants at high risk of atypical neurocognitive development. Many infants were imaged more than once to provide longitudinal data, and the total number of datasets being released is 887. We now describe the dHCP image acquisition and processing protocols, summarize the available imaging and collateral data, and provide information on how the data can be accessed., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Edwards, Rueckert, Smith, Abo Seada, Alansary, Almalbis, Allsop, Andersson, Arichi, Arulkumaran, Bastiani, Batalle, Baxter, Bozek, Braithwaite, Brandon, Carney, Chew, Christiaens, Chung, Colford, Cordero-Grande, Counsell, Cullen, Cupitt, Curtis, Davidson, Deprez, Dillon, Dimitrakopoulou, Dimitrova, Duff, Falconer, Farahibozorg, Fitzgibbon, Gao, Gaspar, Harper, Harrison, Hughes, Hutter, Jenkinson, Jbabdi, Jones, Karolis, Kyriakopoulou, Lenz, Makropoulos, Malik, Mason, Mortari, Nosarti, Nunes, O’Keeffe, O’Muircheartaigh, Patel, Passerat-Palmbach, Pietsch, Price, Robinson, Rutherford, Schuh, Sotiropoulos, Steinweg, Teixeira, Tenev, Tournier, Tusor, Uus, Vecchiato, Williams, Wright, Wurie and Hajnal.)

Purpose: A framework to design radiofrequency (RF) pulses specifically to minimize the TR of gradient echo sequences is presented, subject to hardware and physiological constraints., Methods: Single-band and multiband (MB) RF pulses can be reduced in duration using variable-rate selective excitation (VERSE) VERSE for a range of flip angles; however, minimum-duration pulses do not guarantee minimum TR because these can lead to a high specific absorption rate (SAR). The optimal RF pulse is found by meeting spatial encoding, peripheral nerve stimulation (PNS) and SAR constraints. A TR reduction for a range of designs is achieved and an application of this in an MB cardiac balanced steady-state free-precession (bSSFP) experiment is presented. Gradient imperfections and their imaging effects are also considered., Results: Sequence TR with low-time bandwidth product (TBP) pulses, as used in bSSFP, was reduced up to 14%, and the TR when using high TBP pulses, as used in slab-selective imaging, was reduced by up to 72%. A breath-hold cardiac exam was reduced by 46% using both MB and the TR-optimal framework. The importance of RF-based correction of gradient imperfections is demonstrated. PNS was not a practical limitation., Conclusion: The TR-optimal framework designs RF pulses for a range of pulse parameters, specifically to minimize sequence TR., (© 2021 International Society for Magnetic Resonance in Medicine.)

Purpose: This study incorporates a gradient system imperfection model into an optimal control framework for radio frequency (RF) pulse design., Theory and Methods: The joint design of minimum-time RF and slice selective gradient shapes is posed as an optimal control problem. Hardware limitations such as maximal amplitudes for RF and slice selective gradient or its slew rate are included as hard constraints to assure practical applicability of the optimized waveforms. In order to guarantee the performance of the optimized waveform with possible gradient system disturbances such as limited system bandwidth and eddy currents, a measured gradient impulse response function (GIRF) for a specific system is integrated into the optimization., Results: The method generates optimized RF and pre-distorted slice selective gradient shapes for refocusing that are able to fully compensate the modeled imperfections of the gradient system under investigation. The results nearly regenerate the optimal results of an idealized gradient system. The numerical Bloch simulations are validated by phantom and in-vivo experiments on 2 3T scanners., Conclusions: The presented design approach demonstrates the successful correction of gradient system imperfections within an optimal control framework for RF pulse design., (© 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.)

Impaired brain development has been observed in newborns with congenital heart disease (CHD). We performed graph theoretical analyses and network-based statistics (NBS) to assess global brain network topology and identify subnetworks of altered connectivity in infants with CHD prior to cardiac surgery. Fifty-eight infants with critical/serious CHD prior to surgery and 116 matched healthy controls as part of the developing Human Connectome Project (dHCP) underwent MRI on a 3T system and high angular resolution diffusion MRI (HARDI) was obtained. Multi-tissue constrained spherical deconvolution, anatomically constrained probabilistic tractography (ACT) and spherical-deconvolution informed filtering of tractograms (SIFT2) was used to construct weighted structural networks. Network topology was assessed and NBS was used to identify structural connectivity differences between CHD and control groups. Structural networks were partitioned into core and peripheral nodes, and edges classed as core, peripheral, or feeder. NBS identified one subnetwork with reduced structural connectivity in CHD infants involving basal ganglia, amygdala, hippocampus, cerebellum, vermis, and temporal and parieto-occipital lobe, primarily affecting core nodes and edges. However, we did not find significantly different global network characteristics in CHD neonates. This locally affected sub-network with reduced connectivity could explain, at least in part, the neurodevelopmental impairments associated with CHD., (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)

Purpose: Simultaneous multi-slice techniques are reliant on multiband RF pulses, for which conventional design strategies result in long pulse durations, lengthening echo-times so lowering SNR for spin-echo imaging, and lengthening repetition times for gradient echo sequences. Pulse durations can be reduced with advanced RF pulse design methods that use time-variable selection gradients. However, the ability of gradient systems to reproduce fast switching pulses is often limited and can lead to image artifacts when ignored. We propose a time-efficient pulse design method that inherently produces gradient waveforms with lower temporal bandwidth., Methods: Efficient multiband RF pulses with time-variable gradients were designed using time-optimal VERSE. Using VERSE directly on multiband pulses leads to gradient waveforms with high temporal bandwidth, whereas VERSE applied first to singleband RF pulses and then modulated to make them multiband, significantly reduces this. The relative performance of these approaches was compared using simulation and experimental measurements., Results: Applying VERSE before multiband modulation was successful at removing out-of-band slice distortion. This effectively removes the need for high frequency modulation in the gradient waveform while preserving the benefit of time-efficiency inherited from VERSE., Conclusion: We propose a time-efficient RF pulse design that produces gradient pulses with lower temporal bandwidth, reducing image artifacts associated with finite temporal bandwidth of gradient systems., (© International Society for Magnetic Resonance in Medicine.)

Purpose: Multiband pulses are characterized by highly temporally modulated waveforms. Rapid phase or frequency modulation can be extremely demanding on the performance of radiofrequency (RF) pulse generation, which can lead to errors that can be avoided if pulses are restricted to amplitude modulation (AM) only. In this work, three existing multiband pulse design techniques are modified to produce AM waveforms., Theory and Methods: Multiband refocusing pulses were designed using phase-optimization, time-shifting, and root-flipping. Each technique was constrained to produce AM pulses by exploiting conjugate symmetry in their respective frequency domain representations. Pulses were designed using the AM and unconstrained techniques for a range of multiband factors (ie, number of simultaneously excited slices), time-bandwidth products, and slice separations. Performance was compared by examining the resulting effective pulse durations. Phantom and in vivo experiments were conducted for validation., Results: Acquired data confirmed that AM pulses can produce precise results when unconstrained designs may produce artifacts. The average duration of AM pulses is longer than the unconstrained versions. Averaged across a range of parameters, the duration cost for AM pulses was 26, 38, and 20% for phase-optimizing, time-shifting and root-flipping, respectively., Conclusions: Amplitude modulation multiband pulses can be produced for a relatively small increase in pulse duration. Magn Reson Med 78:2185-2193, 2017. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited., (© 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.)