21 results on '"Aboagye, Jeremy"'
Number of results to display per page
Search Results
2. Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial
- Author
-
Datoo, Mehreen S, Natama, Hamtandi Magloire, Somé, Athanase, Bellamy, Duncan, Traoré, Ousmane, Rouamba, Toussaint, Tahita, Marc Christian, Ido, N Félix André, Yameogo, Prisca, Valia, Daniel, Millogo, Aida, Ouedraogo, Florence, Soma, Rachidatou, Sawadogo, Seydou, Sorgho, Faizatou, Derra, Karim, Rouamba, Eli, Ramos-Lopez, Fernando, Cairns, Matthew, Provstgaard-Morys, Samuel, Aboagye, Jeremy, Lawrie, Alison, Roberts, Rachel, Valéa, Innocent, Sorgho, Hermann, Williams, Nicola, Glenn, Gregory, Fries, Louis, Reimer, Jenny, Ewer, Katie J, Shaligram, Umesh, Hill, Adrian V S, and Tinto, Halidou
- Published
- 2022
- Full Text
- View/download PDF
3. Safety and immunogenicity of a simian-adenovirus-vectored rabies vaccine: an open-label, non-randomised, dose-escalation, first-in-human, single-centre, phase 1 clinical trial
- Author
-
Jenkin, Daniel, Ritchie, Adam J, Aboagye, Jeremy, Fedosyuk, Sofiya, Thorley, Luke, Provstgaad-Morys, Samuel, Sanders, Helen, Bellamy, Duncan, Makinson, Rebecca, Xiang, Zhi Quan, Bolam, Emma, Tarrant, Richard, Ramos Lopez, Fernando, Platt, Abigail, Poulton, Ian, Green, Catherine, Ertl, Hildegund C J, Ewer, Katie J, and Douglas, Alexander D
- Published
- 2022
- Full Text
- View/download PDF
4. Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)
- Author
-
Adlou, Syed, Aley, Robert, Ali, Aabidah, Anslow, Rachel, Baker, Megan, Baker, Phillip, Barrett, Jordan R., Bates, Louise, Beadon, Kirsten, Beckley, Rebecca, Bell, Jonathan, Bellamy, Duncan, Beveridge, Amy, Bissett, Cameron, Blackwell, Luke, Bletchly, Heather, Boyd, Amy, Bridges-Webb, Alice, Brown, Charlie, Byard, Nicholas, Camara, Susana, Cifuentes Gutierrez, Liliana, Collins, Andrea M., Cooper, Rachel, Crocker, Wendy E.M., Darton, Thomas C., Davies, Hannah, Davies, Judith, Demissie, Tesfaye, Di Maso, Claudio, Dinesh, Tanya, Donnellan, Francesca R., Douglas, Alexander D., Drake-Brockman, Rachael, Duncan, Christopher J.A., Elias, Sean C., Emary, Katherine R.W., Ghulam Farooq, Mutjaba, Faust, Saul N., Felle, Sally, Ferreira, Daniela, Ferreira Da Silva, Carla, Finn, Adam, Ford, Karen J., Francis, Emma, Furze, Julie, Fuskova, Michelle, Galiza, Eva, Gibertoni Cruz, Ana, Godfrey, Leila, Goodman, Anna L., Green, Catherine, Green, Christopher A., Greenwood, Nicola, Harrison, Daisy, Hart, Thomas C., Hawkins, Sophia, Heath, Paul T., Hill, Helen, Hillson, Kushalinii, Horsington, Bryn, Hou, Mimi M., Howe, Elizabeth, Howell, Nicola, Joe, Carina, Jones, Elizabeth, Kasanyinga, Mwila, Keen, Jade, Kelly, Sarah, Kerr, David, Khan, Liaquat, Khozoee, Baktash, Kinch, Jasmin, Kinch, Patrick, Koleva, Stanislava, Kwok, Jonathan, Larkworthy, Colin W., Lawrie, Alison M., Lazarus, Rajeka, Lees, Emily A., Li, Grace, Libri, Vincenzo, Lillie, Patrick J., Linder, Aline, Long, Fei, Lopez Ramon, Raquel, Mabbett, Reece, Makinson, Rebecca, Marinou, Spyridoula, Marlow, Emma, Marshall, Julia L., Mazur, Olga, McEwan, Joanne, McGregor, Alastair C., Mokaya, Jolynne, Morey, Ella, Morshead, Gertraud, Morter, Richard, Muller, Jilly, Mweu, Philomena, Noristani, Rabiullah, Owino, Nelly, Polo Peralta Alvarez, Marco, Platt, Abigail, Pollock, Katrina M., Poulton, Ian, Provstgaard-Morys, Samuel, Pulido-Gomez, David, Rajan, Matthew, Ramos Lopez, Fernando, Ritchie, Adam, Roberts, Hannah, Rollier, Christine, Rudiansyah, Indra, Sanders, Katherine, Saunders, Jack E., Seddiqi, Samiullah, Sharpe, Hannah R., Shaw, Robert, Silva-Reyes, Laura, Singh, Nisha, Smith, David J., Smith, Catherine C., Smith, Andrew, Spencer, Alexandra J., Stuart, Arabella S.V., Sutherland, Rebecca, Szigeti, Anna, Tang, Karly, Thomas, Merin, Thomas, Tonia M., Thompson, Amber, Thomson, Emma C., Török, Estée M., Toshner, Mark, Tran, Nguyen, Trivett, Rose, Turnbull, Iain, Turner, Cheryl, Turner, David P.J., Ulaszewska, Marta, Vichos, Iason, Walker, Laura, Watson, Marion E., Whelan, Conor, White, Rachel, Williams, Sarah J., Williams, Christopher J.A., Wright, Daniel, Yao, Andy, Flaxman, Amy, Marchevsky, Natalie G, Jenkin, Daniel, Aboagye, Jeremy, Aley, Parvinder K, Angus, Brian, Belij-Rammerstorfer, Sandra, Bibi, Sagida, Bittaye, Mustapha, Cappuccini, Federica, Cicconi, Paola, Clutterbuck, Elizabeth A, Davies, Sophie, Dejnirattisai, Wanwisa, Dold, Christina, Ewer, Katie J, Folegatti, Pedro M, Fowler, Jamie, Hill, Adrian V S, Kerridge, Simon, Minassian, Angela M, Mongkolsapaya, Juthathip, Mujadidi, Yama F, Plested, Emma, Ramasamy, Maheshi N, Robinson, Hannah, Sanders, Helen, Sheehan, Emma, Smith, Holly, Snape, Matthew D, Song, Rinn, Woods, Danielle, Screaton, Gavin, Gilbert, Sarah C, Voysey, Merryn, Pollard, Andrew J, and Lambe, Teresa
- Published
- 2021
- Full Text
- View/download PDF
5. T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
- Author
-
Ewer, Katie J., Barrett, Jordan R., Belij-Rammerstorfer, Sandra, Sharpe, Hannah, Makinson, Rebecca, Morter, Richard, Flaxman, Amy, Alderson, Jennifer, Bittaye, Mustapha, Dold, Christina, Provine, Nicholas M., Aboagye, Jeremy, Fowler, Jamie, Silk, Sarah E., Aley, Parvinder K., Bellamy, Duncan, and Wright, Daniel
- Subjects
T cells -- Physiological aspects ,Biological sciences ,Health - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), has caused a global pandemic, and safe, effective vaccines are urgently needed.sup.1. Strong, Th1-skewed T cell responses can drive protective humoral and cell-mediated immune responses.sup.2 and might reduce the potential for disease enhancement.sup.3. Cytotoxic T cells clear virus-infected host cells and contribute to control of infection.sup.4. Studies of patients infected with SARS-CoV-2 have suggested a protective role for both humoral and cell-mediated immune responses in recovery from COVID-19 (refs. .sup.5,6). ChAdOx1 nCoV-19 (AZD1222) is a candidate SARS-CoV-2 vaccine comprising a replication-deficient simian adenovirus expressing full-length SARS-CoV-2 spike protein. We recently reported preliminary safety and immunogenicity data from a phase 1/2 trial of the ChAdOx1 nCoV-19 vaccine (NCT04400838).sup.7 given as either a one- or two-dose regimen. The vaccine was tolerated, with induction of neutralizing antibodies and antigen-specific T cells against the SARS-CoV-2 spike protein. Here we describe, in detail, exploratory analyses of the immune responses in adults, aged 18-55 years, up to 8 weeks after vaccination with a single dose of ChAdOx1 nCoV-19 in this trial, demonstrating an induction of a Th1-biased response characterized by interferon-[gamma] and tumor necrosis factor-[alpha] cytokine secretion by CD4.sup.+ T cells and antibody production predominantly of IgG1 and IgG3 subclasses. CD8.sup.+ T cells, of monofunctional, polyfunctional and cytotoxic phenotypes, were also induced. Taken together, these results suggest a favorable immune profile induced by ChAdOx1 nCoV-19 vaccine, supporting the progression of this vaccine candidate to ongoing phase 2/3 trials to assess vaccine efficacy. A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection., Author(s): Katie J. Ewer [sup.1] , Jordan R. Barrett [sup.1] , Sandra Belij-Rammerstorfer [sup.1] , Hannah Sharpe [sup.1] , Rebecca Makinson [sup.1] , Richard Morter [sup.1] , Amy Flaxman [sup.1] [...]
- Published
- 2021
- Full Text
- View/download PDF
6. Safety and immunogenicity of varied doses of R21/Matrix-M™ vaccine at three years follow-up: A phase 1b age de-escalation, dose-escalation trial in adults, children, and infants in Kilifi-Kenya
- Author
-
Sang, Samuel, primary, Datoo, Mehreen S., additional, Otieno, Edward, additional, Muiruri, Charles, additional, Bellamy, Duncan, additional, Gathuri, Emmaloise, additional, Ngoto, Omar, additional, Musembi, Janet, additional, Provstgaard-Morys, Sam, additional, Stockdale, Lisa, additional, Aboagye, Jeremy, additional, Woods, Daniel, additional, Lawrie, Alison, additional, Roberts, Racheal, additional, Keter, Kelvias, additional, Kimani, Domtila, additional, Ndungu, Francis, additional, Kapulu, Melissa, additional, Njau, Irene, additional, Orindi, Benedict, additional, Ewer, Katie J., additional, Hill, Adrian V.S., additional, Bejon, Philip, additional, and Hamaluba, Mainga, additional
- Published
- 2023
- Full Text
- View/download PDF
7. Persistence of the immune response after two doses of ChAdOx1 nCov-19 (AZD1222): 1 year of follow-up of two randomized controlled trials
- Author
-
Voysey, Merryn, primary, Flaxman, Amy, additional, Aboagye, Jeremy, additional, Aley, Parvinder K, additional, Belij-Rammerstorfer, Sandra, additional, Bibi, Sagida, additional, Bittaye, Mustapha, additional, Cappuccini, Federica, additional, Charlton, Sue, additional, Clutterbuck, Elizabeth A, additional, Davies, Sophie, additional, Dold, Christina, additional, Edwards, Nick J, additional, Ewer, Katie J, additional, Faust, Saul N, additional, Folegatti, Pedro M, additional, Fowler, Jamie, additional, Gilbride, Ciaran, additional, Gilbert, Sarah C, additional, Godfrey, Leila, additional, Hallis, Bassam, additional, Humphries, Holly E, additional, Jenkin, Daniel, additional, Kerridge, Simon, additional, Mujadidi, Yama F, additional, Plested, Emma, additional, Ramasamy, Maheshi N, additional, Robinson, Hannah, additional, Sanders, Helen, additional, Snape, Matthew D, additional, Song, Rinn, additional, Thomas, Kelly M, additional, Ulaszewska, Marta, additional, Woods, Danielle, additional, Wright, Daniel, additional, Pollard, Andrew J, additional, and Lambe, Teresa, additional
- Published
- 2023
- Full Text
- View/download PDF
8. A Phase 1b Clinical Trial to Determine the Safety, Tolerability and Immunogenicity of the Candidate Mycobacterium Avium Complex Subspecies Vaccines ChAdOx2 HAV and MVA HAV in Patients with Active Crohn's Disease
- Author
-
Sanderson, Jeremy, primary, Aboagye, Jeremy, additional, Makinson, Rebecca, additional, Rapi, Katerina, additional, Provstgaard-Morys, Samuel, additional, Stockdale, Lisa, additional, Lawrie, Alison M., additional, Lanigan, Isabelle, additional, Halim, Nishat, additional, Douiri, Abdel, additional, Greenlay, Emily, additional, Malek, Rayka, additional, Gray, Emma, additional, West, Lindsey, additional, El Oulidi, Fatima, additional, Cross, Paul Ian, additional, Stallibrass, Michael, additional, Gilbert, Sarah C., additional, Hill, Adrian V. S., additional, and Ewer, Katie J., additional
- Published
- 2023
- Full Text
- View/download PDF
9. The Public Health Impact and Cost-Effectiveness of the R21/Matrix-M Malaria Vaccine: A Mathematical Modelling Study
- Author
-
Schmit, Nora, primary, Topazian, Hillary M., additional, Natama, Magloire H., additional, Bellamy, Duncan, additional, Traoré, Ousmane, additional, Some, Athasana M., additional, Rouamba, Toussaint, additional, Tahita, Marc C., additional, Bonko, Massa Achille, additional, Sourabié, Aboubakary, additional, Sorgho, Hermann, additional, Stockdale, Lisa, additional, Provstgaard-Morys, Samuel, additional, Aboagye, Jeremy, additional, Woods, Danielle, additional, Rapi, Katerina, additional, Datoo, Mehreen S., additional, Lopez, Fernando Ramos, additional, Charles, Giovanni, additional, McCain, Kelly, additional, Ouédraogo, Jean-Bosco, additional, Hamaluba, Mainga, additional, Olotu, Ally, additional, Dicko, Alassane, additional, Tinto, Halidou, additional, Hill, Adrian V. S., additional, Ewer, Katie, additional, Ghani, Azra, additional, and Winskill, Peter, additional
- Published
- 2023
- Full Text
- View/download PDF
10. Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I trial
- Author
-
Madhavan, Meera, primary, Ritchie, Adam J., additional, Aboagye, Jeremy, additional, Jenkin, Daniel, additional, Provstgaad-Morys, Samuel, additional, Tarbet, Iona, additional, Woods, Danielle, additional, Davies, Sophie, additional, Baker, Megan, additional, Platt, Abigail, additional, Flaxman, Amy, additional, Smith, Holly, additional, Belij-Rammerstorfer, Sandra, additional, Wilkins, Deidre, additional, Kelly, Elizabeth J., additional, Villafana, Tonya, additional, Green, Justin A., additional, Poulton, Ian, additional, Lambe, Teresa, additional, Hill, Adrian V.S., additional, Ewer, Katie J., additional, and Douglas, Alexander D., additional
- Published
- 2022
- Full Text
- View/download PDF
11. Safety and immunogenicity of ChAdOx1 MERS vaccine candidate in healthy Middle Eastern adults (MERS002): an open-label, non-randomised, dose-escalation, phase 1b trial
- Author
-
Bosaeed, Mohammad, primary, Balkhy, Hanan H, additional, Almaziad, Sultan, additional, Aljami, Haya A, additional, Alhatmi, Hind, additional, Alanazi, Hala, additional, Alahmadi, Mashael, additional, Jawhary, Ayah, additional, Alenazi, Mohammed W, additional, Almasoud, Abdulrahman, additional, Alanazi, Rawan, additional, Bittaye, Mustapha, additional, Aboagye, Jeremy, additional, Albaalharith, Nahla, additional, Batawi, Sarah, additional, Folegatti, Pedro, additional, Ramos Lopez, Fernando, additional, Ewer, Katie, additional, Almoaikel, Khalid, additional, Aljeraisy, Majed, additional, Alothman, Adel, additional, Gilbert, Sarah C, additional, and Khalaf Alharbi, Naif, additional
- Published
- 2022
- Full Text
- View/download PDF
12. Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)
- Author
-
Flaxman, Amy, Marchevsky, Natalie G, Jenkin, Daniel, Aboagye, Jeremy, Aley, Parvinder K, Angus, Brian, Belij-Rammerstorfer, Sandra, Bibi, Sagida, Bittaye, Mustapha, Cappuccini, Federica, Cicconi, Paola, Clutterbuck, Elizabeth A, Davies, Sophie, Dejnirattisai, Wanwisa, Dold, Christina, Ewer, Katie J, Folegatti, Pedro M, Fowler, Jamie, Hill, Adrian VS, Kerridge, Simon, Minassian, Angela M, Mongkolsapaya, Juthathip, Mujadidi, Yama F, Plested, Emma, Ramasamy, Maheshi N, Robinson, Hannah, Sanders, Helen, Sheehan, Emma, Smith, Holly, Snape, Matthew D, Song, Rinn, Woods, Danielle, Screaton, Gavin, Gilbert, Sarah C, Voysey, Merryn, Pollard, Andrew J, Lambe, Teresa, and Oxford COVID Vaccine Trial group
- Abstract
BACKGROUND: COVID-19 vaccine supply shortages are causing concerns about compromised immunity in some countries as the interval between the first and second dose becomes longer. Conversely, countries with no supply constraints are considering administering a third dose. We assessed the persistence of immunogenicity after a single dose of ChAdOx1 nCoV-19 (AZD1222), immunity after an extended interval (44-45 weeks) between the first and second dose, and response to a third dose as a booster given 28-38 weeks after the second dose. METHODS: In this substudy, volunteers aged 18-55 years who were enrolled in the phase 1/2 (COV001) controlled trial in the UK and had received either a single dose or two doses of 5 × 1010 viral particles were invited back for vaccination. Here we report the reactogenicity and immunogenicity of a delayed second dose (44-45 weeks after first dose) or a third dose of the vaccine (28-38 weeks after second dose). Data from volunteers aged 18-55 years who were enrolled in either the phase 1/2 (COV001) or phase 2/3 (COV002), single-blinded, randomised controlled trials of ChAdOx1 nCoV-19 and who had previously received a single dose or two doses of 5 × 1010 viral particles are used for comparison purposes. COV001 is registered with ClinicalTrials.gov, NCT04324606, and ISRCTN, 15281137, and COV002 is registered with ClinicalTrials.gov, NCT04400838, and ISRCTN, 15281137, and both are continuing but not recruiting. FINDINGS: Between March 11 and 21, 2021, 90 participants were enrolled in the third-dose boost substudy, of whom 80 (89%) were assessable for reactogenicity, 75 (83%) were assessable for evaluation of antibodies, and 15 (17%) were assessable for T-cells responses. The two-dose cohort comprised 321 participants who had reactogenicity data (with prime-boost interval of 8-12 weeks: 267 [83%] of 321; 15-25 weeks: 24 [7%]; or 44-45 weeks: 30 [9%]) and 261 who had immunogenicity data (interval of 8-12 weeks: 115 [44%] of 261; 15-25 weeks: 116 [44%]; and 44-45 weeks: 30 [11%]). 480 participants from the single-dose cohort were assessable for immunogenicity up to 44-45 weeks after vaccination. Antibody titres after a single dose measured approximately 320 days after vaccination remained higher than the titres measured at baseline (geometric mean titre of 66·00 ELISA units [EUs; 95% CI 47·83-91·08] vs 1·75 EUs [1·60-1·93]). 32 participants received a late second dose of vaccine 44-45 weeks after the first dose, of whom 30 were included in immunogenicity and reactogenicity analyses. Antibody titres were higher 28 days after vaccination in those with a longer interval between first and second dose than for those with a short interval (median total IgG titre: 923 EUs [IQR 525-1764] with an 8-12 week interval; 1860 EUs [917-4934] with a 15-25 week interval; and 3738 EUs [1824-6625] with a 44-45 week interval). Among participants who received a third dose of vaccine, antibody titres (measured in 73 [81%] participants for whom samples were available) were significantly higher 28 days after a third dose (median total IgG titre: 3746 EUs [IQR 2047-6420]) than 28 days after a second dose (median 1792 EUs [IQR 899-4634]; Wilcoxon signed rank test p=0·0043). T-cell responses were also boosted after a third dose (median response increased from 200 spot forming units [SFUs] per million peripheral blood mononuclear cells [PBMCs; IQR 127-389] immediately before the third dose to 399 SFUs per milion PBMCs [314-662] by day 28 after the third dose; Wilcoxon signed rank test p=0·012). Reactogenicity after a late second dose or a third dose was lower than reactogenicity after a first dose. INTERPRETATION: An extended interval before the second dose of ChAdOx1 nCoV-19 leads to increased antibody titres. A third dose of ChAdOx1 nCoV-19 induces antibodies to a level that correlates with high efficacy after second dose and boosts T-cell responses. FUNDING: UK Research and Innovation, Engineering and Physical Sciences Research Council, National Institute for Health Research, Coalition for Epidemic Preparedness Innovations, National Institute for Health Research Oxford Biomedical Research Centre, Chinese Academy of Medical Sciences Innovation Fund for Medical Science, Thames Valley and South Midlands NIHR Clinical Research Network, AstraZeneca, and Wellcome.
- Published
- 2021
13. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
- Author
-
Voysey, Merryn, Clemens, Sue Ann Costa, Madhi, Shabir A., Weckx, Lily Y., Folegatti, Pedro M., Aley, Parvinder K., Angus, Brian, Baillie, Vicky L., Barnabas, Shaun L., Bhorat, Qasim E., Bibi, Sagida, Briner, Carmen, Cicconi, Paola, Collins, Andrea M., Colin-Jones, Rachel, Cutland, Clare L., Darton, Thomas C., Dheda, Keertan, Duncan, Christopher J.A., Emary, Katherine R.W., Ewer, Katie J., Fairlie, Lee, Faust, Saul N., Feng, Shuo, Ferreira, Daniela M., Finn, Adam, Goodman, Anna L., Green, Catherine M., Green, Christopher A., Heath, Paul T., Hill, Catherine, Hill, Helen, Hirsch, Ian, Hodgson, Susanne H.C., Izu, Alane, Jackson, Susan, Jenkin, Daniel, Joe, Carina C.D., Kerridge, Simon, Koen, Anthonet, Kwatra, Gaurav, Lazarus, Rajeka, Lawrie, Alison M., Lelliott, Alice, Libri, Vincenzo, Lillie, Patrick J., Mallory, Raburn, Mendes, Ana V.A., Milan, Eveline P., Minassian, Angela M., McGregor, Alastair, Morrison, Hazel, Mujadidi, Yama F., Nana, Anusha, O'Reilly, Peter J., Padayachee, Sherman D., Pittella, Ana, Plested, Emma, Pollock, Katrina M., Ramasamy, Maheshi N., Rhead, Sarah, Schwarzbold, Alexandre V., Singh, Nisha, Smith, Andrew, Song, Rinn, Snape, Matthew D., Sprinz, Eduardo, Sutherland, Rebecca K., Tarrant, Richard, Thomson, Emma C., Toshner, Mark, Turner, David P.J., Vekemans, Johan, Villafana, Tonya L., Watson, Marion E.E., Williams, Christopher J., Douglas, Alexander D., Hill, Adrian V.S., Lambe, Teresa, Gilbert, Sarah C., Pollard, Andrew J., Aban, Marites, Abayomi, Fatola, Abeyskera, Kushala, Aboagye, Jeremy, Adam, Matthew, Adams, Kirsty, Adamson, James, Adelaja, Yemi A., Adlou, Syed, Ahmed, Khatija, Akhalwaya, Yasmeen, Akhalwaya, Saajida, Alcock, Andrew, Ali, Aabidah, Allen, Elizabeth R., Allen, Lauren, Almeida, Thamires C.D.S.C., and Alves, Mariana P.S.
- Subjects
General Medicine - Abstract
© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. Funding: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca.
- Published
- 2021
14. T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
- Author
-
Ewer, Katie J., Barrett, Jordan R., Belij-Rammerstorfer, Sandra, Sharpe, Hannah, Makinson, Rebecca, Morter, Richard, Flaxman, Amy, Wright, Daniel, Bellamy, Duncan, Bittaye, Mustapha, Dold, Christina, Provine, Nicholas M., Aboagye, Jeremy, Fowler, Jamie, Silk, Sarah E., Alderson, Jennifer, Aley, Parvinder K., Angus, Brian, Berrie, Eleanor, Bibi, Sagida, Cicconi, Paola, Clutterbuck, Elizabeth A., Chelysheva, Irina, Folegatti, Pedro M., Fuskova, Michelle, Green, Catherine M., Jenkin, Daniel, Kerridge, Simon, Lawrie, Alison, Minassian, Angela M., Moore, Maria, Mujadidi, Yama, Plested, Emma, Poulton, Ian, Ramasamy, Maheshi N., Robinson, Hannah, Song, Rinn, Snape, Matthew D., Tarrant, Richard, Voysey, Merryn, Watson, Marion E. E., Douglas, Alexander D., Hill, Adrian V. S., Gilbert, Sarah C., Pollard, Andrew J., Lambe, Teresa, Ali, Aabidah, Allen, Elizabeth, Baker, Megan, Barnes, Eleanor, Borthwick, Nicola, Boyd, Amy, Brown-O’Sullivan, Charlie, Burgoyne, Joshua, Byard, Nicholas, Puig, Ingrid Cabrera, Cappuccini, Federica, Cho, Jee-Sun, Clark, Elizabeth, Crocker, Wendy E. M., Datoo, Mehreen S., Davies, Hannah, Donnellan, Francesca R., Dunachie, Susanna Jane, Edwards, Nick J., Elias, Sean C., Furze, Julie, Gilbride, Ciaran, Gorini, Giacomo, Gupta, Gaurav, Harris, Stephanie A., Hodgson, Susanne H. C., Hou, Mimi M., Jackson, Susan, Jones, Kathryn, Kailath, Reshma, King, Lloyd, Larkworthy, Colin W., Li, Yuanyuan, Lias, Amelia M., Linder, Aline, Lipworth, Samuel, Ramon, Raquel Lopez, Madhavan, Meera, Marlow, Emma, Marshall, Julia L., Mentzer, Alexander J., Morrison, Hazel, Moya, Nathifa, Mukhopadhyay, Ekta, Noé, Andrés, Nugent, Fay L., Pipini, Dimitra, Pulido-Gomez, David, Lopez, Fernando Ramos, Ritchie, Adam John, Rudiansyah, Indra, Salvador, Stephannie, Sanders, Helen, Satti, Iman, Shea, Adam, Silk, Sarah, Spencer, Alexandra J., Tanner, Rachel, Taylor, Iona Jennifer, Themistocleous, Yrene, Thomas, Merin, Tran, Nguyen, Truby, Adam, Turner, Cheryl, Turner, Nicola, Ulaszewska, Marta, Worth, Andrew T., Kingham-Page, Lucy, Alvarez, Marco Polo Peralta, Anslow, Rachel, Bates, Louise, Beadon, Kirsten, Beckley, Rebecca, Beveridge, Amy, Bijker, Else Margreet, Blackwell, Luke, Burbage, Jamie, Camara, Susana, Carr, Melanie, Colin-Jones, Rachel, Cooper, Rachel, Cunningham, Christina J., Demissie, Tesfaye, Maso, Claudio Di, Douglas, Naomi, Drake-Brockman, Rachael, Drury, Ruth Elizabeth, Emary, Katherine R. W., Felle, Sally, Feng, Shuo, Silva, Carla Ferreira Da, Ford, Karen J., Francis, Emma, Gracie, Lara, Hamlyn, Joseph, Hanumunthadu, Brama, Harrison, Daisy, Hart, Thomas C., Hawkins, Sophia, Hill, Jennifer, Howe, Elizabeth, Howell, Nicola, Jones, Elizabeth, Keen, Jade, Kelly, Sarah, Kerr, David, Khan, Liaquat, Kinch, Jasmin, Koleva, Stanislava, Lees, Emily A., Lelliott, Alice, Liu, Xinxue, Marchevsky, Natalie G., Marinou, Spyridoula, McEwan, Joanne, Morey, Ella, Morshead, Gertraud, Muller, Jilly, Munro, Claire, Murphy, Sarah, Mweu, Philomena, Nuthall, Elizabeth, O’Brien, Katie, O’Connor, Daniel, O’Reilly, Peter John, Oguti, Blanché, Osborne, Piper, Owino, Nelly, Parker, Kaye, Pfafferott, Katja, Phillips, Daniel, Provstgaard-Morys, Samuel, Ratcliffe, Helen, Rawlinson, Thomas, Rhead, Sarah, Roberts, Hannah, Sanders, Katherine, Silva-Reyes, Laura, Rollier, Christine S., Smith, Catherine C., Smith, David J., Stockdale, Lisa, Szigeti, Anna, Thomas, Tonia M., Thompson, Amber, Tomic, Adriana, Tonks, Susan, Varughese, Rachel, Verheul, Marije K., Vichos, Iason, Walker, Laura, White, Caroline, White, Rachel, Yao, Xin Li, Conlon, Christopher P., Frater, John, Cifuentes, Liliana, Baleanu, Ioana, Bolam, Emma, Boland, Elena, Brenner, Tanja, Damratoski, Brad E., Datta, Chandra, Muhanna, Omar El, Fisher, Richard, Galian-Rubio, Pablo, Hodges, Gina, Jackson, Frederic, Liu, Shuchang, Loew, Lisa, Morgans, Roisin, Morris, Susan Jane, Olchawski, Vicki, Oliveria, Catarina, Parracho, Helena, Pabon, Emilia Reyes, Tahiri-Alaoui, Abdessamad, Taylor, Keja, Williams, Paul, Zizi, Dalila, Arbe-Barnes, Edward H., Baker, Philip, Batten, Alexander, Downing, Charlotte, Drake, Jonathan, English, Marcus Rex, Henry, John Aaron, Iveson, Poppy, Killen, Annabel, King, Thomas B., Larwood, Jessica P. J., Mallett, Garry, Mansatta, Kushal, Mirtorabi, Neginsadat, Patrick-Smith, Maia, Perring, James, Radia, Kajal, Roche, Sophie, Schofield, Ella, Naude, Rebecca te Water, Towner, James, Baker, Natalie, Bewley, Kevin R., Brunt, Emily, Buttigieg, Karen R., Carroll, Miles W., Charlton, Sue, Coombes, Naomi S., Elmore, Michael J., Godwin, Kerry, Hallis, Bassam, Knott, Daniel, McInroy, Lorna, Shaik, Imam, Thomas, Kelly, Tree, Julia A., Blundell, Caitlin L., Cao, Michelangelo, Kelly, Dearbhla, Schmid, Annina, Skelly, Donal T., Themistocleous, Andreas, Dong, Tao, Field, Samantha, Hamilton, Elizabeth, Kelly, Elizabeth, Klenerman, Paul, Knight, Julian C., Lie, Yolanda, Petropoulos, Christos, Sedik, Cynthia, Wrin, Terri, Meddaugh, Gretchen, Peng, Yanchun, Screaton, Gavin, and Stafford, Elizabeth
- Subjects
0301 basic medicine ,biology ,business.industry ,T cell ,Immunogenicity ,General Medicine ,Vaccine efficacy ,General Biochemistry, Genetics and Molecular Biology ,Vaccination ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Immune system ,Immunity ,030220 oncology & carcinogenesis ,Immunology ,biology.protein ,medicine ,Cytotoxic T cell ,Antibody ,business - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), has caused a global pandemic, and safe, effective vaccines are urgently needed1. Strong, Th1-skewed T cell responses can drive protective humoral and cell-mediated immune responses2 and might reduce the potential for disease enhancement3. Cytotoxic T cells clear virus-infected host cells and contribute to control of infection4. Studies of patients infected with SARS-CoV-2 have suggested a protective role for both humoral and cell-mediated immune responses in recovery from COVID-19 (refs. 5,6). ChAdOx1 nCoV-19 (AZD1222) is a candidate SARS-CoV-2 vaccine comprising a replication-deficient simian adenovirus expressing full-length SARS-CoV-2 spike protein. We recently reported preliminary safety and immunogenicity data from a phase 1/2 trial of the ChAdOx1 nCoV-19 vaccine (NCT04400838)7 given as either a one- or two-dose regimen. The vaccine was tolerated, with induction of neutralizing antibodies and antigen-specific T cells against the SARS-CoV-2 spike protein. Here we describe, in detail, exploratory analyses of the immune responses in adults, aged 18–55 years, up to 8 weeks after vaccination with a single dose of ChAdOx1 nCoV-19 in this trial, demonstrating an induction of a Th1-biased response characterized by interferon-γ and tumor necrosis factor-α cytokine secretion by CD4+ T cells and antibody production predominantly of IgG1 and IgG3 subclasses. CD8+ T cells, of monofunctional, polyfunctional and cytotoxic phenotypes, were also induced. Taken together, these results suggest a favorable immune profile induced by ChAdOx1 nCoV-19 vaccine, supporting the progression of this vaccine candidate to ongoing phase 2/3 trials to assess vaccine efficacy. A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.
- Published
- 2020
- Full Text
- View/download PDF
15. Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies
- Author
-
Folegatti, Pedro M., primary, Flaxman, Amy, additional, Jenkin, Daniel, additional, Makinson, Rebecca, additional, Kingham-Page, Lucy, additional, Bellamy, Duncan, additional, Ramos Lopez, Fernando, additional, Sheridan, Jonathan, additional, Poulton, Ian, additional, Aboagye, Jeremy, additional, Tran, Nguyen, additional, Mitton, Celia, additional, Roberts, Rachel, additional, Lawrie, Alison M., additional, Hill, Adrian V. S., additional, Ewer, Katie J., additional, and Gilbert, Sarah, additional
- Published
- 2021
- Full Text
- View/download PDF
16. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
- Author
-
Voysey, Merryn, primary, Costa Clemens, Sue Ann, additional, Madhi, Shabir A, additional, Weckx, Lily Y, additional, Folegatti, Pedro M, additional, Aley, Parvinder K, additional, Angus, Brian, additional, Baillie, Vicky L, additional, Barnabas, Shaun L, additional, Bhorat, Qasim E, additional, Bibi, Sagida, additional, Briner, Carmen, additional, Cicconi, Paola, additional, Clutterbuck, Elizabeth A, additional, Collins, Andrea M, additional, Cutland, Clare L, additional, Darton, Thomas C, additional, Dheda, Keertan, additional, Dold, Christina, additional, Duncan, Christopher J A, additional, Emary, Katherine R W, additional, Ewer, Katie J, additional, Flaxman, Amy, additional, Fairlie, Lee, additional, Faust, Saul N, additional, Feng, Shuo, additional, Ferreira, Daniela M, additional, Finn, Adam, additional, Galiza, Eva, additional, Goodman, Anna L, additional, Green, Catherine M, additional, Green, Christopher A, additional, Greenland, Melanie, additional, Hill, Catherine, additional, Hill, Helen C, additional, Hirsch, Ian, additional, Izu, Alane, additional, Jenkin, Daniel, additional, Joe, Carina C D, additional, Kerridge, Simon, additional, Koen, Anthonet, additional, Kwatra, Gaurav, additional, Lazarus, Rajeka, additional, Libri, Vincenzo, additional, Lillie, Patrick J, additional, Marchevsky, Natalie G, additional, Marshall, Richard P, additional, Mendes, Ana V A, additional, Milan, Eveline P, additional, Minassian, Angela M, additional, McGregor, Alastair, additional, Mujadidi, Yama F, additional, Nana, Anusha, additional, Padayachee, Sherman D, additional, Phillips, Daniel J, additional, Pittella, Ana, additional, Plested, Emma, additional, Pollock, Katrina M, additional, Ramasamy, Maheshi N, additional, Ritchie, Adam J, additional, Robinson, Hannah, additional, Schwarzbold, Alexandre V, additional, Smith, Andrew, additional, Song, Rinn, additional, Snape, Matthew D, additional, Sprinz, Eduardo, additional, Sutherland, Rebecca K, additional, Thomson, Emma C, additional, Török, M Estée, additional, Toshner, Mark, additional, Turner, David P J, additional, Vekemans, Johan, additional, Villafana, Tonya L, additional, White, Thomas, additional, Williams, Christopher J, additional, Douglas, Alexander D, additional, Hill, Adrian V S, additional, Lambe, Teresa, additional, Gilbert, Sarah C, additional, Pollard, Andrew J, additional, Aban, Marites, additional, Abeyskera, Kushala W.M., additional, Aboagye, Jeremy, additional, Adam, Matthew, additional, Adams, Kirsty, additional, Adamson, James P., additional, Adewatan, Gbadebo, additional, Adlou, Syed, additional, Ahmed, Khatija, additional, Akhalwaya, Yasmeen, additional, Akhalwaya, Saajida, additional, Alcock, Andrew, additional, Ali, Aabidah, additional, Allen, Elizabeth R., additional, Allen, Lauren, additional, Alvernaz, Felipe B., additional, Amorim, Fabio Santos, additional, Andrade, Claudia Sala, additional, Andritsou, Foteini, additional, Anslow, Rachel, additional, Arbe-Barnes, Edward H., additional, Ariaans, Mark P., additional, Arns, Beatriz, additional, Arruda, Laiana, additional, Assad, Luiza, additional, Azi, Paula De Almeida, additional, Azi, Lorena De Almeida, additional, Babbage, Gavin, additional, Bailey, Catherine, additional, Baker, Kenneth F., additional, Baker, Megan, additional, Baker, Natalie, additional, Baker, Philip, additional, Baleanu, Ioana, additional, Bandeira, Danieli, additional, Bara, Anna, additional, Barbosa, Marcella A.S., additional, Barker, Debbie, additional, Barlow, Gavin D., additional, Barnes, Eleanor, additional, Barr, Andrew S., additional, Barrett, Jordan R., additional, Barrett, Jessica, additional, Barrett, Kelly, additional, Bates, Louise, additional, Batten, Alexander, additional, Beadon, Kirsten, additional, Beales, Emily, additional, Beckley, Rebecca, additional, Belij-Rammerstorfer, Sandra, additional, Bell, Jonathan, additional, Bellamy, Duncan, additional, Belton, Sue, additional, Berg, Adam, additional, Bermejo, Laura, additional, Berrie, Eleanor, additional, Berry, Lisa, additional, Berzenyi, Daniella, additional, Beveridge, Amy, additional, Bewley, Kevin R., additional, Bharaj, Inderjeet, additional, Bhikha, Sutika, additional, Bhorat, Asad E., additional, Bhorat, Zaheda E., additional, Bijker, Else Margreet, additional, Birch, Sarah, additional, Birch, Gurpreet, additional, Birchall, Kathryn, additional, Bird, Adam, additional, Bird, Olivia, additional, Bisnauthsing, Karen, additional, Bittaye, Mustapha, additional, Blackwell, Luke, additional, Blacow, Rachel, additional, Bletchly, Heather, additional, Blundell, Caitlin L., additional, Blundell, Susannah R., additional, Bodalia, Pritesh, additional, Bolam, Emma, additional, Boland, Elena, additional, Bormans, Daan, additional, Borthwick, Nicola, additional, Bowring, Francesca, additional, Boyd, Amy, additional, Bradley, Penny, additional, Brenner, Tanja, additional, Bridges-Webb, Alice, additional, Brown, Phillip, additional, Brown, Claire, additional, Brown-O'Sullivan, Charlie, additional, Bruce, Scott, additional, Brunt, Emily, additional, Budd, William, additional, Bulbulia, Yusuf A., additional, Bull, Melanie, additional, Burbage, Jamie, additional, Burn, Aileen, additional, Buttigieg, Karen R., additional, Byard, Nicholas, additional, Cabrera Puig, Ingrid, additional, Calvert, Anna, additional, Camara, Susana, additional, Cao, Michelangelo, additional, Cappuccini, Federica, additional, Cardona, Rita, additional, Cardoso, João R., additional, Carr, Melanie, additional, Carroll, Miles W., additional, Carson-Stevens, Andrew, additional, Carvalho, Yasmin de M., additional, Casey, Helen R., additional, Cashen, Paul, additional, Castro, Thais R.Y., additional, Castro, Lucia Carratala, additional, Cathie, Katrina, additional, Cavey, Ana, additional, Cerbino-Neto, José, additional, Cezar, Luiz Fernando F., additional, Chadwick, Jim, additional, Chanice, Chanice, additional, Chapman, David, additional, Charlton, Sue, additional, Cheliotis, Katerina S., additional, Chelysheva, Irina, additional, Chester, Oliver, additional, Chiplin, Emily, additional, Chita, Sunder, additional, Cho, Jee-Sun, additional, Cifuentes, Liliana, additional, Clark, Elizabeth, additional, Clark, Matthew, additional, Colin-Jones, Rachel, additional, Collins, Sarah L.K., additional, Colton, Hayley, additional, Conlon, Christopher P., additional, Connarty, Sean, additional, Coombes, Naomi, additional, Cooper, Cushla, additional, Cooper, Rachel, additional, Cornelissen, Lynne, additional, Corrah, Tumena, additional, Cosgrove, Catherine A., additional, Costa, Fernanda Barroso, additional, Cox, Tony, additional, Crocker, Wendy E.M., additional, Crosbie, Sarah, additional, Cullen, Dan, additional, Cunha, Debora R.M.F., additional, Cunningham, Christina J., additional, Cuthbertson, Fiona C., additional, da Costa, Daniel Marinho, additional, Da Guarda, Suzete N. Farias, additional, da Silva, Larissa P., additional, da Silva Moraes, Antonio Carlos, additional, Damratoski, Brad E., additional, Danos, Zsofia, additional, Dantas, Maria T.D.C., additional, Datoo, Mehreen S., additional, Datta, Chandrabali, additional, Davids, Malika, additional, Davies, Sarah L., additional, Davies, Kelly, additional, Davies, Hannah, additional, Davies, Sophie, additional, Davies, Judith, additional, Davis, Elizabeth J., additional, Davis, John, additional, de Carvalho, José A.M., additional, De Jager, Jeanne, additional, de Jesus Jnr, Sergio, additional, De Oliveira Kalid, Lis Moreno, additional, Dearlove, David, additional, Demissie, Tesfaye, additional, Desai, Amisha, additional, Di Marco, Stefania, additional, Di Maso, Claudio, additional, Dinesh, Tanya, additional, Docksey, Claire, additional, Dong, Tao, additional, Donnellan, Francesca R., additional, Dos Santos, Tannyth Gomes, additional, Dos Santos, Thainá G., additional, Dos Santos, Erika Pachecho, additional, Douglas, Naomi, additional, Downing, Charlotte, additional, Drake, Jonathan, additional, Drake-Brockman, Rachael, additional, Drury, Ruth, additional, Du Plessis, Joan, additional, Dunachie, Susanna J., additional, Duncan, Andrew, additional, Easom, Nicholas J.W., additional, Edwards, Mandy, additional, Edwards, Nick J., additional, Edwards, Frances, additional, El Muhanna, Omar M., additional, Elias, Sean C., additional, Ellison-Handley, Branwen, additional, Elmore, Michael J., additional, English, Marcus Rex, additional, Esmail, Alisgair, additional, Essack, Yakub Moosa, additional, Farooq, Mutjaba, additional, Fedosyuk, Sofiya, additional, Felle, Sally, additional, Ferguson, Susie, additional, Ferreira Da Silva, Carla, additional, Field, Samantha, additional, Fisher, Richard, additional, Fletcher, James, additional, Fofie, Hazel, additional, Fok, Henry, additional, Ford, Karen J., additional, Fothergill, Ross, additional, Fowler, Jamie, additional, Fraiman, Pedro H.A., additional, Francis, Emma, additional, Franco, Marilia M., additional, Frater, John, additional, Freire, Marilúcia S.M., additional, Fry, Samantha H., additional, Fudge, Sabrina, additional, Furlan Filho, Renato, additional, Furze, Julie, additional, Fuskova, Michelle, additional, Galian-Rubio, Pablo, additional, Garlant, Harriet, additional, Gavrila, Madita, additional, Gibbons, Karyna A., additional, Gilbride, Ciaran, additional, Gill, Hardeep, additional, Godwin, Kerry, additional, Gokani, Karishma, additional, Gonçalves, Maria Luisa Freire, additional, Gonzalez, Isabela G.S., additional, Goodall, Jack, additional, Goodwin, Jayne, additional, Goondiwala, Amina, additional, Gordon-Quayle, Katherine, additional, Gorini, Giacomo, additional, Goyanna, Alvaro, additional, Grab, Janet, additional, Gracie, Lara, additional, Green, Justin, additional, Greenwood, Nicola, additional, Greffrath, Johann, additional, Groenewald, Marisa M., additional, Gunawardene, Anishka, additional, Gupta, Gaurav, additional, Hackett, Mark, additional, Hallis, Bassam, additional, Hamaluba, Mainga, additional, Hamilton, Elizabeth, additional, Hamlyn, Joseph, additional, Hammersley, Daniel, additional, Hanrath, Aidan T., additional, Hanumunthadu, Brama, additional, Harris, Stephanie A., additional, Harris, Clair, additional, Harrison, Thomas D., additional, Harrison, Daisy, additional, Harris-Wright, Tara A., additional, Hart, Thomas C., additional, Hartnell, Birgit, additional, Haughney, John, additional, Hawkins, Sophia, additional, Hayano, Laís Y.M., additional, Head, Ian, additional, Heath, Paul T., additional, Henry, John Aaron, additional, Hermosin Herrera, Macarena, additional, Hettle, David B., additional, Higa, Cristhiane, additional, Hill, Jennifer, additional, Hodges, Gina, additional, Hodgson, Susanne, additional, Horne, Elizea, additional, Hou, Mimi M., additional, Houlihan, Catherine F., additional, Howe, Elizabeth, additional, Howell, Nicola, additional, Humphreys, Jonathan, additional, Humphries, Holly E., additional, Hurley, Katrina, additional, Huson, Claire, additional, Hyams, Catherine, additional, Hyder-Wright, Angela, additional, Ikram, Sabina, additional, Ishwarbhai, Alka, additional, Iveson, Poppy, additional, Iyer, Vidyashankara, additional, Jackson, Frederic, additional, Jackson, Susan, additional, Jaumdally, Shameem, additional, Jeffers, Helen, additional, Jesudason, Natasha, additional, Jones, Carina, additional, Jones, Christopher, additional, Jones, Kathryn, additional, Jones, Elizabeth, additional, Jorge, Marianna Rocha, additional, Joshi, Amar, additional, Júnior, Eduardo A.M.S., additional, Kailath, Reshma, additional, Kana, Faeeza, additional, Kar, Arnab, additional, Karampatsas, Konstantinos, additional, Kasanyinga, Mwila, additional, Kay, Linda, additional, Keen, Jade, additional, Kellett Wright, Johanna, additional, Kelly, Elizabeth J., additional, Kelly, Debbie, additional, Kelly, Dearbhla M., additional, Kelly, Sarah, additional, Kerr, David, additional, Khan, Liaquat, additional, Khozoee, Baktash, additional, Khurana, Ankush, additional, Kidd, Sarah, additional, Killen, Annabel, additional, Kinch, Jasmin, additional, Kinch, Patrick, additional, King, Lloyd D.W., additional, King, Thomas B., additional, Kingham, Lucy, additional, Klenerman, Paul, additional, Kluczna, Diana M., additional, Knapper, Francesca, additional, Knight, Julian C., additional, Knott, Daniel, additional, Koleva, Stanislava, additional, Lages, Pedro M., additional, Lang, Matilda, additional, Lang, Gail, additional, Larkworthy, Colin W., additional, Larwood, Jessica P.J., additional, Law, Rebecca, additional, Lawrie, Alison M., additional, Lazarus, Erica M., additional, Leach, Amanda, additional, Lees, Emily A., additional, Lelliott, Alice, additional, Lemm, Nana-Marie, additional, Lessa, Alvaro Edson Ramos, additional, Leung, Stephanie, additional, Li, Yuanyuan, additional, Lias, Amelia M., additional, Liatsikos, Konstantinos, additional, Linder, Aline, additional, Lipworth, Samuel, additional, Liu, Shuchang, additional, Liu, Xinxue, additional, Lloyd, Adam, additional, Lloyd, Stephanie, additional, Loew, Lisa, additional, Lopez Ramon, Raquel, additional, Lora, Leandro Bonecker, additional, Luz, Kleber Giovanni, additional, MacDonald, Jonathan C., additional, MacGregor, Gordon, additional, Madhavan, Meera, additional, Mainwaring, David O., additional, Makambwa, Edson, additional, Makinson, Rebecca, additional, Malahleha, Mookho, additional, Malamatsho, Ross, additional, Mallett, Garry, additional, Manning, Nicola, additional, Mansatta, Kushal, additional, Maoko, Takalani, additional, Marinou, Spyridoula, additional, Marlow, Emma, additional, Marques, Gabriela N., additional, Marriott, Paula, additional, Marshall, Richard P., additional, Marshall, Julia L., additional, Masenya, Masebole, additional, Masilela, Mduduzi, additional, Masters, Shauna K., additional, Mathew, Moncy, additional, Matlebjane, Hosea, additional, Matshidiso, Kedidimetse, additional, Mazur, Olga, additional, Mazzella, Andrea, additional, McCaughan, Hugh, additional, McEwan, Joanne, additional, McGlashan, Joanna, additional, McInroy, Lorna, additional, McRobert, Nicky, additional, McSwiggan, Steve, additional, Megson, Clare, additional, Mehdipour, Savviz, additional, Meijs, Wilma, additional, Mendonça, Renata N.Õ., additional, Mentzer, Alexander J., additional, Mesquita, Ana Carolina F., additional, Miralhes, Patricia, additional, Mirtorabi, Neginsadat, additional, Mitton, Celia, additional, Mnyakeni, Sibusiso, additional, Moghaddas, Fiona, additional, Molapo, Kgaogelo, additional, Moloi, Mapule, additional, Moore, Maria, additional, Moran, Marni, additional, Morey, Ella, additional, Morgans, Róisín, additional, Morris, Susan J., additional, Morris, Sheila, additional, Morrison, Hazel, additional, Morselli, Franca, additional, Morshead, Gertraud, additional, Morter, Richard, additional, Mottay, Lynelle, additional, Moultrie, Andrew, additional, Moyo, Nathifa, additional, Mpelembue, Mushiya, additional, Msomi, Sibekezelo, additional, Mugodi, Yvonne, additional, Mukhopadhyay, Ekta, additional, Muller, Jilly, additional, Munro, Alasdair, additional, Murphy, Sarah, additional, Mweu, Philomena, additional, Myerscough, Christopher, additional, Naik, Gurudutt, additional, Naker, Kush, additional, Nastouli, Eleni, additional, Ndlovu, Bongani, additional, Nikolaou, Elissavet, additional, Njenga, Cecilia, additional, Noal, Helena C., additional, Noé, Andrés, additional, Novaes, Gabrielle, additional, Nugent, Fay L., additional, Nunes, Géssika Lanzillo A., additional, O'Brien, Katie, additional, O'Connor, Daniel, additional, Oelofse, Suzette, additional, Oguti, Blanche, additional, Olchawski, Victoria, additional, Oldfield, Neil J., additional, Oliveira, Marianne G., additional, Oliveira, Catarina, additional, Oliveira, Isabelle Silva Queiroz, additional, Oommen-Jose, Aylin, additional, Oosthuizen, Angela, additional, O'Reilly, Paula, additional, O'Reilly, Peter J., additional, Osborne, Piper, additional, Owen, David R.J., additional, Owen, Lydia, additional, Owens, Daniel, additional, Owino, Nelly, additional, Pacurar, Mihaela, additional, Paiva, Brenda V.B., additional, Palhares, Edna M.F., additional, Palmer, Susan, additional, Parracho, Helena M. R.T., additional, Parsons, Karen, additional, Patel, Dipak, additional, Patel, Bhumika, additional, Patel, Faeezah, additional, Patrick-Smith, Maia, additional, Payne, Ruth O., additional, Peng, Yanchun, additional, Penn, Elizabeth J., additional, Pennington, Anna, additional, Peralta Alvarez, Marco Polo, additional, Pereira Stuchi, Bruno Pereira, additional, Perez, Ana Luiza, additional, Perinpanathan, Tanaraj, additional, Perring, James, additional, Perumal, Rubeshan, additional, Petkar, Sahir Yusuf, additional, Philip, Tricia, additional, Phillips, Jennifer, additional, Phohu, Mary Kgomotso, additional, Pickup, Lorinda, additional, Pieterse, Sonja, additional, Pinheiro, Jessica Morgana, additional, Piper, Jo, additional, Pipini, Dimitra, additional, Plank, Mary, additional, Plant, Sinéad, additional, Pollard, Samuel, additional, Pooley, Jennifer, additional, Pooran, Anil, additional, Poulton, Ian, additional, Powers, Claire, additional, Presa, Fernando B., additional, Price, David A., additional, Price, Vivien, additional, Primeira, Marcelo R., additional, Proud, Pamela C., additional, Provstgaard-Morys, Samuel, additional, Pueschel, Sophie, additional, Pulido, David, additional, Quaid, Sheena, additional, Rabara, Ria, additional, Radia, Kajal, additional, Rajapaska, Durga, additional, Rajeswaran, Thurkka, additional, Ramos, Leonardo, additional, Ramos, Alberto San Francisco, additional, Ramos Lopez, Fernando, additional, Rampling, Tommy, additional, Rand, Jade, additional, Ratcliffe, Helen, additional, Rawlinson, Tom, additional, Rea, David, additional, Rees, Byron, additional, Resuello-Dauti, Mila, additional, Reyes Pabon, Emilia, additional, Rhead, Sarah, additional, Riaz, Tawassal, additional, Ricamara, Marivic, additional, Richards, Alexander, additional, Richter, Alex, additional, Ritchie, Neil, additional, Ritchie, Adam J., additional, Robbins, Alexander J., additional, Roberts, Hannah, additional, Robinson, Ryan E., additional, Roche, Sophie, additional, Rollier, Christine, additional, Rose, Louisa, additional, Ross Russell, Amy L., additional, Rossouw, Lindie, additional, Royal, Simon, additional, Rudiansyah, Indra, additional, Ryalls, Kim, additional, Sabine, Charlotte, additional, Saich, Stephen, additional, Sale, Jessica C., additional, Salman, Ahmed M., additional, Salvador, Natalia, additional, Salvador, Stephannie, additional, Sampaio, Milla Dias, additional, Samson, Annette D., additional, Sanchez-Gonzalez, Amada, additional, Sanders, Helen, additional, Sanders, Katherine, additional, Santos, Erika, additional, Santos Guerra, Mayara F.S., additional, Satti, Iman, additional, Saunders, Jack E., additional, Saunders, Caroline, additional, Sayed, Aakifah Bibi Arif, additional, Schim van der Loeff, Ina, additional, Schmid, Annina B., additional, Schofield, Ella, additional, Screaton, Gavin R., additional, Seddiqi, Samiullah, additional, Segireddy, Rameswara R., additional, Senger, Roberta, additional, Serrano, Sonia, additional, Shaik, Imam, additional, Sharpe, Hannah R., additional, Sharrocks, Katherine, additional, Shaw, Robert, additional, Shea, Adam, additional, Sheehan, Emma, additional, Shepherd, Amy, additional, Shiham, Farah, additional, Silk, Sarah E., additional, Silva-Reyes, Laura, additional, Silveira, Lidiana B. T.D., additional, Silveira, Mariana B.V., additional, Singh, Nisha, additional, Sinha, Jaisi, additional, Skelly, Donal T., additional, Smith, Daniel C., additional, Smith, Nick, additional, Smith, Holly E., additional, Smith, David J., additional, Smith, Catherine C., additional, Soares, Airanuédida S., additional, Solórzano, Carla, additional, Sorio, Guilherme L., additional, Sorley, Kim, additional, Sosa-Rodriguez, Tiffany, additional, Souza, Cinthia M.C.D.L., additional, Souza, Bruno S.D.F., additional, Souza, Alessandra R., additional, Souza Lopez, Thamyres, additional, Sowole, Luciana, additional, Spencer, Alexandra J., additional, Spoors, Louise, additional, Stafford, Lizzie, additional, Stamford, Imogen, additional, Stein, Ricardo, additional, Stockdale, Lisa, additional, Stockwell, Lisa V., additional, Strickland, Louise H., additional, Stuart, Arabella, additional, Sturdy, Ann, additional, Sutton, Natalina, additional, Szigeti, Anna, additional, Tahiri-Alaoui, Abdessamad, additional, Tanner, Rachel, additional, Taoushanis, Carol, additional, Tarr, Alexander W., additional, Tarrant, Richard, additional, Taylor, Keja, additional, Taylor, Ursula, additional, Taylor, Iona Jennifer, additional, Taylor, Justin, additional, te Water Naude, Rebecca, additional, Templeton, Kate, additional, Themistocleous, Yrene, additional, Themistocleous, Andreas, additional, Thomas, Merin, additional, Thomas, Kelly, additional, Thomas, Tonia M., additional, Thombrayil, Asha, additional, Thompson, Julia, additional, Thompson, Fawziyah, additional, Thompson, Ameeka, additional, Thompson, Amber, additional, Thompson, Kevin, additional, Thornton-Jones, Viv, additional, Thotusi, Larissa H.S., additional, Tighe, Patrick J., additional, Tinoco, Lygia Accioly, additional, Tiongson, Gerlynn Ferreras, additional, Tladinyane, Bonolo, additional, Tomasicchio, Michele, additional, Tomic, Adriana, additional, Tonks, Susan, additional, Towner, James, additional, Tran, Nguyen, additional, Tree, Julia A., additional, Trillana, Gerry, additional, Trinham, Charlotte, additional, Trivett, Rose, additional, Truby, Adam, additional, Tsheko, Betty Lebogang, additional, Tubb, Philippa, additional, Turabi, Aadil, additional, Turner, Richard, additional, Turner, Cheryl, additional, Turner, Nicola, additional, Tyagi, Bhavya, additional, Ulaszewska, Marta, additional, Underwood, Benjamin R., additional, van Eck, Samual, additional, Varughese, Rachel, additional, Verbart, Dennis, additional, Verheul, Marije K., additional, Vichos, Iason, additional, Vieira, Taiane A., additional, Walker, Gemma, additional, Walker, Laura, additional, Wand, Matthew E., additional, Wardell, Theresa, additional, Warimwe, George M., additional, Warren, Sarah C., additional, Watkins, Bridget, additional, Watson, Marion E.E., additional, Watson, Ekaterina, additional, Webb, Stewart, additional, Webster, Angela, additional, Welch, Jessica, additional, Wellbelove, Zoe, additional, Wells, Jeanette H., additional, West, Alison J., additional, White, Beth, additional, White, Caroline, additional, White, Rachel, additional, Williams, Paul, additional, Williams, Rachel L., additional, Willingham, Silvia, additional, Winslow, Rebecca, additional, Woods, Danielle, additional, Woodyer, Mark, additional, Worth, Andrew T., additional, Wright, Danny, additional, Wroblewska, Marzena, additional, Yao, Andy, additional, Yim, Yee Ting Nicole, additional, Zambrano, Marina Bauer, additional, Zimmer, Rafael Leal, additional, Zizi, Dalila, additional, and Zuidewind, Peter, additional
- Published
- 2021
- Full Text
- View/download PDF
17. Tolerability and Immunogenicity After a Late Second Dose or a Third Dose of ChAdOx1 nCoV-19 (AZD1222)
- Author
-
Flaxman, Amy, primary, Marchevsky, Natalie, additional, Jenkin, Daniel, additional, Aboagye, Jeremy, additional, Aley, Parvinder K., additional, Angus, Brian John, additional, Belij-Rammerstorfer, Sandra, additional, Bibi, Sagida, additional, Bittaye, Mustapha, additional, Cappuccini, Federica, additional, Cicconi, Paola, additional, Clutterbuck, Elizabeth, additional, Davies, Sophie, additional, Dejnirattisai, Wanwisa, additional, Dold, Christina, additional, Ewer, Katie, additional, Folegatti, Pedro M., additional, Fowler, Jamie, additional, Hill, Adrian V. S., additional, Kerridge, Simon, additional, Minassian, Angela M., additional, Mongkolspaya, Juthathip, additional, Farooq Mujadidi, Yama, additional, Plested, Emma, additional, Ramasamy, Maheshi N., additional, Robinson, Hannah, additional, Sanders, Helen, additional, Sheehan, Emma, additional, Smith, Holly, additional, Snape, Matthew D., additional, Song, Rinn, additional, Woods, Danielle, additional, Screaton, Gavin R., additional, Gilbert, Sarah C., additional, Voysey, Merryn, additional, Pollard, Andrew, additional, Lambe, Teresa, additional, and Group, The Oxford COVID Vaccine, additional
- Published
- 2021
- Full Text
- View/download PDF
18. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
- Author
-
Ramasamy, Maheshi N, primary, Minassian, Angela M, additional, Ewer, Katie J, additional, Flaxman, Amy L, additional, Folegatti, Pedro M, additional, Owens, Daniel R, additional, Voysey, Merryn, additional, Aley, Parvinder K, additional, Angus, Brian, additional, Babbage, Gavin, additional, Belij-Rammerstorfer, Sandra, additional, Berry, Lisa, additional, Bibi, Sagida, additional, Bittaye, Mustapha, additional, Cathie, Katrina, additional, Chappell, Harry, additional, Charlton, Sue, additional, Cicconi, Paola, additional, Clutterbuck, Elizabeth A, additional, Colin-Jones, Rachel, additional, Dold, Christina, additional, Emary, Katherine R W, additional, Fedosyuk, Sofiya, additional, Fuskova, Michelle, additional, Gbesemete, Diane, additional, Green, Catherine, additional, Hallis, Bassam, additional, Hou, Mimi M, additional, Jenkin, Daniel, additional, Joe, Carina C D, additional, Kelly, Elizabeth J, additional, Kerridge, Simon, additional, Lawrie, Alison M, additional, Lelliott, Alice, additional, Lwin, May N, additional, Makinson, Rebecca, additional, Marchevsky, Natalie G, additional, Mujadidi, Yama, additional, Munro, Alasdair P S, additional, Pacurar, Mihaela, additional, Plested, Emma, additional, Rand, Jade, additional, Rawlinson, Thomas, additional, Rhead, Sarah, additional, Robinson, Hannah, additional, Ritchie, Adam J, additional, Ross-Russell, Amy L, additional, Saich, Stephen, additional, Singh, Nisha, additional, Smith, Catherine C, additional, Snape, Matthew D, additional, Song, Rinn, additional, Tarrant, Richard, additional, Themistocleous, Yrene, additional, Thomas, Kelly M, additional, Villafana, Tonya L, additional, Warren, Sarah C, additional, Watson, Marion E E, additional, Douglas, Alexander D, additional, Hill, Adrian V S, additional, Lambe, Teresa, additional, Gilbert, Sarah C, additional, Faust, Saul N, additional, Pollard, Andrew J, additional, Aboagye, Jeremy, additional, Adams, Kelly, additional, Ali, Aabidah, additional, Allen, Elizabeth R., additional, Allen, Lauren, additional, Allison, Jennifer L., additional, Andritsou, Foteini, additional, Anslow, Rachel, additional, Arbe-Barnes, Edward H., additional, Baker, Megan, additional, Baker, Natalie, additional, Baker, Philip, additional, Baleanu, Ioana, additional, Barker, Debbie, additional, Barnes, Eleanor, additional, Barrett, Jordan R., additional, Barrett, Kelly, additional, Bates, Louise, additional, Batten, Alexander, additional, Beadon, Kirsten, additional, Beckley, Rebecca, additional, Bellamy, Duncan, additional, Berg, Adam, additional, Bermejo, Laura, additional, Berrie, Eleanor, additional, Beveridge, Amy, additional, Bewley, Kevin, additional, Bijker, Else M., additional, Birch, Geeta, additional, Blackwell, Luke, additional, Bletchly, Heather, additional, Blundell, Caitlin L., additional, Blundell, Susannah R., additional, Bolam, Emma, additional, Boland, Elena, additional, Bormans, Daan, additional, Borthwick, Nicola, additional, Boukas, Konstantinos, additional, Bower, Thomas, additional, Bowring, Francesca, additional, Boyd, Amy, additional, Brenner, Tanja, additional, Brown, Phillip, additional, Brown-O'Sullivan, Charlie, additional, Bruce, Scott, additional, Brunt, Emily, additional, Burbage, Jamie, additional, Burgoyne, Joshua, additional, Buttigieg, Karen R., additional, Byard, Nicholas, additional, Cabera Puig, Ingrid, additional, Camara, Susana, additional, Cao, Michelangelo, additional, Cappuccini, Federica, additional, Carr, Melanie, additional, Carroll, Miles W., additional, Cashen, Paul, additional, Cavey, Ana, additional, Chadwick, Jim, additional, Challis, Ruth, additional, Chapman, David, additional, Charles, David, additional, Chelysheva, Irina, additional, Cho, Jee-Sun, additional, Cifuentes, Liliana, additional, Clark, Elizabeth, additional, Collins, Sarah, additional, Conlon, Christopher P., additional, Coombes, Naomi S., additional, Cooper, Rachel, additional, Cooper, Cushla, additional, Crocker, Wendy E.M., additional, Crosbie, Sarah, additional, Cullen, Dan, additional, Cunningham, Christina, additional, Cuthbertson, Fiona, additional, Datoo, Brad E., additional, Dando, Lynne, additional, Datoo, Mehreen S., additional, Datta, Chandrabali, additional, Davies, Hannah, additional, Davies, Sarah, additional, Davis, Elizabeth J., additional, Davis, Judith, additional, Dearlove, David, additional, Demissie, Tesfaye, additional, Di Marco, Stefania, additional, Di Maso, Claudio, additional, DiTirro, Danielle, additional, Docksey, Claire, additional, Dong, Tao, additional, Donnellan, Francesca R., additional, Douglas, Naomi, additional, Downing, Charlotte, additional, Drake, Jonathan, additional, Drake-Brockman, Rachael, additional, Drury, Ruth E., additional, Dunachie, Susanna J., additional, Edwards, Christopher J., additional, Edwards, Nick J., additional, El Muhanna, Omar, additional, Elias, Sean C., additional, Elliott, Ryan S., additional, Elmore, Michael J., additional, English, Marcus Rex, additional, Felle, Sally, additional, Feng, Shuo, additional, Ferreira Da Silva, Carla, additional, Field, Samantha, additional, Fisher, Richard, additional, Fixmer, Carine, additional, Ford, Karen J., additional, Fowler, Jamie, additional, Francis, Emma, additional, Frater, John, additional, Furze, Julie, additional, Galian-Rubio, Pablo, additional, Galloway, Celine, additional, Garlant, Harriet, additional, Gavrila, Madita, additional, Gibbons, Felicity, additional, Gibbons, Karyna, additional, Gilbride, Ciaran, additional, Gill, Hardeep, additional, Godwin, Kerry, additional, Gordon-Quayle, Katherine, additional, Gorini, Giacomo, additional, Goulston, Lyndsey, additional, Grabau, Caroline, additional, Gracie, Lara, additional, Graham, Nichola, additional, Greenwood, Nicola, additional, Griffiths, Oliver, additional, Gupta, Gaurav, additional, Hamilton, Elizabeth, additional, Hanumunthadu, Brama, additional, Harris, Stephanie A., additional, Harris, Tara, additional, Harrison, Daisy, additional, Hart, Thomas C., additional, Hartnell, Birgit, additional, Haskell, Louise, additional, Hawkins, Sophia, additional, Henry, John Aaron, additional, Hermosin Herrera, Macarena, additional, Hill, David, additional, Hill, Jennifer, additional, Hodges, Gina, additional, Hodgson, Susanne H.C., additional, Horton, Katie L., additional, Howe, Elizabeth, additional, Howell, Nicola, additional, Howes, Jessica, additional, Huang, Ben, additional, Humphreys, Jonathan, additional, Humphries, Holly E., additional, Iveson, Poppy, additional, Jackson, Frederic, additional, Jackson, Susan, additional, Jauregui, Sam, additional, Jeffers, Helen, additional, Jones, Bryony, additional, Jones, Christine E., additional, Jones, Elizabeth, additional, Jones, Kathryn, additional, Joshi, Amar, additional, Kailath, Reshma, additional, Keen, Jade, additional, Kelly, Dearbhla M., additional, Kelly, Sarah, additional, Kelly, Debbie, additional, Kerr, David, additional, Khan, Liaquat, additional, Khozoee, Baktash, additional, Killen, Annabel, additional, Kinch, Jasmin, additional, King, Lloyd D.W., additional, King, Thomas B., additional, Kingham, Lucy, additional, Klenerman, Paul, additional, Knight, Julian C., additional, Knott, Daniel, additional, Koleva, Stanislava, additional, Lang, Gail, additional, Larkworthy, Colin W., additional, Larwood, Jessica P.J., additional, Law, Rebecca, additional, Lee, Arlene, additional, Lee, Kim Y.N., additional, Lees, Emily A., additional, Leung, Stephanie, additional, Li, Yuanyuan, additional, Lias, Amelia M., additional, Linder, Aline, additional, Lipworth, Samuel, additional, Liu, Shuchang, additional, Liu, Xinxue, additional, Lloyd, Stephanie, additional, Loew, Lisa, additional, Lopez Ramon, Raquel, additional, Madhavan, Meera, additional, Mainwaring, David O., additional, Mallett, Garry, additional, Mansatta, Kushal, additional, Marinou, Spyridoula, additional, Marius, Phedra, additional, Marlow, Emma, additional, Marriott, Paula, additional, Marshall, Julia L., additional, Martin, Jane, additional, Masters, Shauna, additional, McEwan, Joanne, additional, McGlashan, Joanna L., additional, McInroy, Lorna, additional, McRobert, Nicky, additional, Megson, Clare, additional, Mentzer, Alexander J., additional, Mirtorabi, Neginsadat, additional, Mitton, Celia, additional, Moore, Maria, additional, Moran, Marni, additional, Morey, Ella, additional, Morgans, Róisín, additional, Morris, Susan J., additional, Morrison, Hazel Morrison, additional, Morshead, Gertraud, additional, Morter, Richard, additional, Moya, Nathifa A., additional, Mukhopadhyay, Ekta, additional, Muller, Jilly, additional, Munro, Claire, additional, Murphy, Sarah, additional, Mweu, Philomena, additional, Noé, Andrés, additional, Nugent, Fay L., additional, O'Brien, Katie, additional, O'Connor, Daniel, additional, Oguti, Blanché, additional, Olchawski, Victoria, additional, Oliveira, Catarina, additional, O'Reilly, Peter John, additional, Osborne, Piper, additional, Owen, Lydia, additional, Owino, Nelly, additional, Papageorgiou, Panagiotis, additional, Parracho, Helena, additional, Parsons, Karen, additional, Patel, Bhumika, additional, Patrick-Smith, Maia, additional, Peng, Yanchun, additional, Penn, Elizabeth J., additional, Peralta-Alvarez, Marco Polo, additional, Perring, James, additional, Petropoulos, Christos, additional, Phillips, Daniel J., additional, Pipini, Dimitra, additional, Pollard, Samuel, additional, Poulton, Ian, additional, Pratt, Danny, additional, Presland, Laura, additional, Proud, Pamela C., additional, Provstgaard-Morys, Samuel, additional, Pueschel, Sophie, additional, Pulido, David, additional, Rabara, Ria, additional, Radia, Kajal, additional, Rajapaska, Durga, additional, Ramos Lopez, Fernando, additional, Ratcliffe, Helen, additional, Rayhan, Sara, additional, Rees, Byron, additional, Reyes Pabon, Emilia, additional, Roberts, Hannah, additional, Robertson, Isla, additional, Roche, Sophie, additional, Rollier, Christine S., additional, Romani, Rossana, additional, Rose, Zoe, additional, Rudiansyah, Indra, additional, Sabheha, Sabeha, additional, Salvador, Stephannie, additional, Sanders, Helen, additional, Sanders, Katherine, additional, Satti, Iman, additional, Sayce, Chloe, additional, Schmid, Annina B., additional, Schofield, Ella, additional, Screaton, Gavin, additional, Sedik, Cynthia, additional, Seddiqi, Samiullah, additional, Segireddy, Rameswara R., additional, Selby, Beatrice, additional, Shaik, Imam, additional, Sharpe, Hannah R., additional, Shaw, Robert, additional, Shea, Adam, additional, Silk, Sarah, additional, Silva-Reyes, Laura, additional, Skelly, Donal T., additional, Smith, David J., additional, Smith, Daniel C., additional, Smith, Nicholas, additional, Spencer, Alexandra J., additional, Spoors, Louise, additional, Stafford, Elizabeth, additional, Stamford, Imogen, additional, Stockdale, Lisa, additional, Stockley, David, additional, Stockwell, Lisa V., additional, Stokes, Matthew, additional, Strickland, Louise H., additional, Stuart, Arabella, additional, Sulaiman, Sulaiman, additional, Summerton, Eloise, additional, Swash, Zoe, additional, Szigeti, Anna, additional, Tahiri-Alaoui, Abdessamad, additional, Tanner, Rachel, additional, Taylor, Iona, additional, Taylor, Keja, additional, Taylor, Ursula, additional, te Water Naude, Rebecca, additional, Themistocleous, Andreas, additional, Thomas, Merin, additional, Thomas, Tonia M., additional, Thompson, Amber, additional, Thompson, Kevin, additional, Thornton-Jones, Viv, additional, Tinh, Lan, additional, Tomic, Adriana, additional, Tonks, Susan, additional, Towner, James, additional, Tran, Nguyen, additional, Tree, Julian A., additional, Truby, Adam, additional, Turner, Cheryl, additional, Turner, Richard, additional, Ulaszewska, Marta, additional, Varughese, Rachel, additional, Verbart, Dennis, additional, Verheul, Marije K., additional, Vichos, Iason, additional, Walker, Laura, additional, Wand, Matthew E., additional, Watkins, Bridget, additional, Welch, Jessica, additional, West, Alison J., additional, White, Caroline, additional, White, Rachel, additional, Williams, Paul, additional, Woodyer, Mark, additional, Worth, Andrew T., additional, Wright, Daniel, additional, Wrin, Terri, additional, Yao, Xin Li, additional, Zbarcea, Diana-Andreea, additional, and Zizi, Dalila, additional
- Published
- 2020
- Full Text
- View/download PDF
19. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
- Author
-
Folegatti, Pedro M, primary, Ewer, Katie J, additional, Aley, Parvinder K, additional, Angus, Brian, additional, Becker, Stephan, additional, Belij-Rammerstorfer, Sandra, additional, Bellamy, Duncan, additional, Bibi, Sagida, additional, Bittaye, Mustapha, additional, Clutterbuck, Elizabeth A, additional, Dold, Christina, additional, Faust, Saul N, additional, Finn, Adam, additional, Flaxman, Amy L, additional, Hallis, Bassam, additional, Heath, Paul, additional, Jenkin, Daniel, additional, Lazarus, Rajeka, additional, Makinson, Rebecca, additional, Minassian, Angela M, additional, Pollock, Katrina M, additional, Ramasamy, Maheshi, additional, Robinson, Hannah, additional, Snape, Matthew, additional, Tarrant, Richard, additional, Voysey, Merryn, additional, Green, Catherine, additional, Douglas, Alexander D, additional, Hill, Adrian V S, additional, Lambe, Teresa, additional, Gilbert, Sarah C, additional, Pollard, Andrew J, additional, Aboagye, Jeremy, additional, Adams, Kelly, additional, Ali, Aabidah, additional, Allen, Elizabeth, additional, Allison, Jennifer L., additional, Anslow, Rachel, additional, Arbe-Barnes, Edward H., additional, Babbage, Gavin, additional, Baillie, Kenneth, additional, Baker, Megan, additional, Baker, Natalie, additional, Baker, Philip, additional, Baleanu, Ioana, additional, Ballaminut, Juliana, additional, Barnes, Eleanor, additional, Barrett, Jordan, additional, Bates, Louise, additional, Batten, Alexander, additional, Beadon, Kirsten, additional, Beckley, Rebecca, additional, Berrie, Eleanor, additional, Berry, Lisa, additional, Beveridge, Amy, additional, Bewley, Kevin R., additional, Bijker, Else Margreet, additional, Bingham, Tracey, additional, Blackwell, Luke, additional, Blundell, Caitlin L., additional, Bolam, Emma, additional, Boland, Elena, additional, Borthwick, Nicola, additional, Bower, Thomas, additional, Boyd, Amy, additional, Brenner, Tanja, additional, Bright, Philip D., additional, Brown-O'Sullivan, Charlie, additional, Brunt, Emily, additional, Burbage, Jamie, additional, Burge, Sharon, additional, Buttigieg, Karen R., additional, Byard, Nicholas, additional, Cabera Puig, Ingrid, additional, Calvert, Anna, additional, Camara, Susana, additional, Cao, Michelangelo, additional, Cappuccini, Federica, additional, Carr, Melanie, additional, Carroll, Miles W., additional, Carter, Victoria, additional, Cathie, Katrina, additional, Challis, Ruth J., additional, Charlton, Sue, additional, Chelysheva, Irina, additional, Cho, Jee-Sun, additional, Cicconi, Paola, additional, Cifuentes, Liliana, additional, Clark, Helen, additional, Clark, Elizabeth, additional, Cole, Tom, additional, Colin-Jones, Rachel, additional, Conlon, Christopher P., additional, Cook, Aislinn, additional, Coombes, Naomi S., additional, Cooper, Rachel, additional, Cosgrove, Catherine A., additional, Coy, Karen, additional, Crocker, Wendy E.M., additional, Cunningham, Christina J., additional, Damratoski, Brad E., additional, Dando, Lynne, additional, Datoo, Mehreen S., additional, Davies, Hannah, additional, De Graaf, Hans, additional, Demissie, Tesfaye, additional, Di Maso, Claudio, additional, Dietrich, Isabelle, additional, Dong, Tao, additional, Donnellan, Francesca R., additional, Douglas, Naomi, additional, Downing, Charlotte, additional, Drake, Jonathan, additional, Drake-Brockman, Rachael, additional, Drury, Ruth Elizabeth, additional, Dunachie, Susanna Jane, additional, Edwards, Nick J., additional, Edwards, Frances D.L., additional, Edwards, Chris J., additional, Elias, Sean C., additional, Elmore, Michael J., additional, Emary, Katherine R.W., additional, English, Marcus Rex, additional, Fagerbrink, Susanne, additional, Felle, Sally, additional, Feng, Shuo, additional, Field, Samantha, additional, Fixmer, Carine, additional, Fletcher, Clare, additional, Ford, Karen J., additional, Fowler, Jamie, additional, Fox, Polly, additional, Francis, Emma, additional, Frater, John, additional, Furze, Julie, additional, Fuskova, Michelle, additional, Galiza, Eva, additional, Gbesemete, Diane, additional, Gilbride, Ciaran, additional, Godwin, Kerry, additional, Gorini, Giacomo, additional, Goulston, Lyndsey, additional, Grabau, Caroline, additional, Gracie, Lara, additional, Gray, Zoe, additional, Guthrie, Lucy Belle, additional, Hackett, Mark, additional, Halwe, Sandro, additional, Hamilton, Elizabeth, additional, Hamlyn, Joseph, additional, Hanumunthadu, Brama, additional, Harding, Irasha, additional, Harris, Stephanie A., additional, Harris, Andrew, additional, Harrison, Daisy, additional, Harrison, Clare, additional, Hart, Thomas C., additional, Haskell, Louise, additional, Hawkins, Sophia, additional, Head, Ian, additional, Henry, John Aaron, additional, Hill, Jennifer, additional, Hodgson, Susanne H.C., additional, Hou, Mimi M., additional, Howe, Elizabeth, additional, Howell, Nicola, additional, Hutlin, Cecilia, additional, Ikram, Sabina, additional, Isitt, Catherine, additional, Iveson, Poppy, additional, Jackson, Susan, additional, Jackson, Frederic, additional, James, Sir William, additional, Jenkins, Megan, additional, Jones, Elizabeth, additional, Jones, Kathryn, additional, Jones, Christine E., additional, Jones, Bryony, additional, Kailath, Reshma, additional, Karampatsas, Konstantinos, additional, Keen, Jade, additional, Kelly, Sarah, additional, Kelly, Dearbhla, additional, Kerr, David, additional, Kerridge, Simon, additional, Khan, Liaquat, additional, Khan, Uzma, additional, Killen, Annabel, additional, Kinch, Jasmin, additional, King, Thomas B., additional, King, Lloyd, additional, King, Jade, additional, Kingham-Page, Lucy, additional, Klenerman, Paul, additional, Knapper, Francesca, additional, Knight, Julian C., additional, Knott, Daniel, additional, Koleva, Stanislava, additional, Kupke, Alexandra, additional, Larkworthy, Colin W., additional, Larwood, Jessica P.J., additional, Laskey, Anna, additional, Lawrie, Alison M., additional, Lee, Arlene, additional, Ngan Lee, Kim Yee, additional, Lees, Emily A, additional, Legge, Helen, additional, Lelliott, Alice, additional, Lemm, Nana-Marie, additional, Lias, Amelia M., additional, Linder, Aline, additional, Lipworth, Samuel, additional, Liu, Xinxue, additional, Liu, Shuchang, additional, Lopez Ramon, Raquel, additional, Lwin, May, additional, Mabesa, Francesca, additional, Madhavan, Meera, additional, Mallett, Garry, additional, Mansatta, Kushal, additional, Marcal, Ines, additional, Marinou, Spyridoula, additional, Marlow, Emma, additional, Marshall, Julia L., additional, Martin, Jane, additional, McEwan, Joanne, additional, McInroy, Lorna, additional, Meddaugh, Gretchen, additional, Mentzer, Alexander J., additional, Mirtorabi, Neginsadat, additional, Moore, Maria, additional, Moran, Edward, additional, Morey, Ella, additional, Morgan, Victoria, additional, Morris, Susan Jane, additional, Morrison, Hazel, additional, Morshead, Gertraud, additional, Morter, Richard, additional, Mujadidi, Yama F., additional, Muller, Jilly, additional, Munera-Huertas, Tatiana, additional, Munro, Claire, additional, Munro, Alasdair, additional, Murphy, Sarah, additional, Munster, Vincent J., additional, Mweu, Philomena, additional, Noé, Andrés, additional, Nugent, Fay L., additional, Nuthall, Elizabeth, additional, O'Brien, Katie, additional, O'Connor, Daniel, additional, Oguti, Blanché, additional, Oliver, Jennifer L., additional, Oliveira, Catarina, additional, O'Reilly, Peter John, additional, Osborn, Mairead, additional, Osborne, Piper, additional, Owen, Cathy, additional, Owens, Daniel, additional, Owino, Nelly, additional, Pacurar, Mihaela, additional, Parker, Kaye, additional, Parracho, Helena, additional, Patrick-Smith, Maia, additional, Payne, Victoria, additional, Pearce, Jennifer, additional, Peng, Yanchun, additional, Peralta Alvarez, Marco Polo, additional, Perring, James, additional, Pfafferott, Katja, additional, Pipini, Dimitra, additional, Plested, Emma, additional, Pluess-Hall, Helen, additional, Pollock, Katrina, additional, Poulton, Ian, additional, Presland, Laura, additional, Provstgaard-Morys, Samuel, additional, Pulido, David, additional, Radia, Kajal, additional, Ramos Lopez, Fernando, additional, Rand, Jade, additional, Ratcliffe, Helen, additional, Rawlinson, Thomas, additional, Rhead, Sarah, additional, Riddell, Amy, additional, Ritchie, Adam John, additional, Roberts, Hannah, additional, Robson, Joanna, additional, Roche, Sophie, additional, Rohde, Cornelius, additional, Rollier, Christine S., additional, Romani, Rossana, additional, Rudiansyah, Indra, additional, Saich, Stephen, additional, Sajjad, Sara, additional, Salvador, Stephannie, additional, Sanchez Riera, Lidia, additional, Sanders, Helen, additional, Sanders, Katherine, additional, Sapaun, Shari, additional, Sayce, Chloe, additional, Schofield, Ella, additional, Screaton, Gavin, additional, Selby, Beatrice, additional, Semple, Calum, additional, Sharpe, Hannah R., additional, Shaik, Imam, additional, Shea, Adam, additional, Shelton, Holly, additional, Silk, Sarah, additional, Silva-Reyes, Laura, additional, Skelly, Donal T., additional, Smee, Heather, additional, Smith, Catherine C., additional, Smith, David J., additional, Song, Rinn, additional, Spencer, Alexandra J., additional, Stafford, Elizabeth, additional, Steele, Amy, additional, Stefanova, Elena, additional, Stockdale, Lisa, additional, Szigeti, Anna, additional, Tahiri-Alaoui, Abdessamad, additional, Tait, Moira, additional, Talbot, Helen, additional, Tanner, Rachel, additional, Taylor, Iona Jennifer, additional, Taylor, Victoria, additional, Te Water Naude, Rebecca, additional, Thakur, Nazia, additional, Themistocleous, Yrene, additional, Themistocleous, Andreas, additional, Thomas, Merin, additional, Thomas, Tonia M., additional, Thompson, Amber, additional, Thomson-Hill, Samantha, additional, Tomlins, Jennifer, additional, Tonks, Susan, additional, Towner, James, additional, Tran, Nguyen, additional, Tree, Julia A., additional, Truby, Adam, additional, Turkentine, Kate, additional, Turner, Cheryl, additional, Turner, Nicola, additional, Turner, Sally, additional, Tuthill, Toby, additional, Ulaszewska, Marta, additional, Varughese, Rachel, additional, Van Doremalen, Neeltje, additional, Veighey, Kristin, additional, Verheul, Marije K., additional, Vichos, Iason, additional, Vitale, Elia, additional, Walker, Laura, additional, Watson, Marion E.E., additional, Welham, Benjamin, additional, Wheat, Julie, additional, White, Caroline, additional, White, Rachel, additional, Worth, Andrew T., additional, Wright, Danny, additional, Wright, Suzie, additional, Yao, Xin Li, additional, and Yau, Yasmine, additional
- Published
- 2020
- Full Text
- View/download PDF
20. Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
- Author
-
Ewer, Katie J., Barrett, Jordan R., Belij-Rammerstorfer, Sandra, Sharpe, Hannah, Makinson, Rebecca, Morter, Richard, Flaxman, Amy, Wright, Daniel, Bellamy, Duncan, Bittaye, Mustapha, Dold, Christina, Provine, Nicholas M., Aboagye, Jeremy, Fowler, Jamie, Silk, Sarah E., Alderson, Jennifer, Aley, Parvinder K., Angus, Brian, Berrie, Eleanor, Bibi, Sagida, Cicconi, Paola, Clutterbuck, Elizabeth A., Chelysheva, Irina, Folegatti, Pedro M., Fuskova, Michelle, Green, Catherine M., Jenkin, Daniel, Kerridge, Simon, Lawrie, Alison, Minassian, Angela M., Moore, Maria, Mujadidi, Yama, Plested, Emma, Poulton, Ian, Ramasamy, Maheshi N., Robinson, Hannah, Song, Rinn, Snape, Matthew D., Tarrant, Richard, Voysey, Merryn, Watson, Marion E. E., Douglas, Alexander D., Hill, Adrian V. S., Gilbert, Sarah C., Pollard, Andrew J., and Lambe, Teresa
- Published
- 2021
- Full Text
- View/download PDF
21. Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002).
- Author
-
Flaxman A, Marchevsky NG, Jenkin D, Aboagye J, Aley PK, Angus B, Belij-Rammerstorfer S, Bibi S, Bittaye M, Cappuccini F, Cicconi P, Clutterbuck EA, Davies S, Dejnirattisai W, Dold C, Ewer KJ, Folegatti PM, Fowler J, Hill AVS, Kerridge S, Minassian AM, Mongkolsapaya J, Mujadidi YF, Plested E, Ramasamy MN, Robinson H, Sanders H, Sheehan E, Smith H, Snape MD, Song R, Woods D, Screaton G, Gilbert SC, Voysey M, Pollard AJ, and Lambe T
- Subjects
- Adult, ChAdOx1 nCoV-19, Female, Humans, Leukocytes, Mononuclear immunology, Male, Middle Aged, Time Factors, United Kingdom, COVID-19 Vaccines administration & dosage, Immunogenicity, Vaccine immunology, Randomized Controlled Trials as Topic, Vaccination
- Abstract
Background: COVID-19 vaccine supply shortages are causing concerns about compromised immunity in some countries as the interval between the first and second dose becomes longer. Conversely, countries with no supply constraints are considering administering a third dose. We assessed the persistence of immunogenicity after a single dose of ChAdOx1 nCoV-19 (AZD1222), immunity after an extended interval (44-45 weeks) between the first and second dose, and response to a third dose as a booster given 28-38 weeks after the second dose., Methods: In this substudy, volunteers aged 18-55 years who were enrolled in the phase 1/2 (COV001) controlled trial in the UK and had received either a single dose or two doses of 5 × 10
10 viral particles were invited back for vaccination. Here we report the reactogenicity and immunogenicity of a delayed second dose (44-45 weeks after first dose) or a third dose of the vaccine (28-38 weeks after second dose). Data from volunteers aged 18-55 years who were enrolled in either the phase 1/2 (COV001) or phase 2/3 (COV002), single-blinded, randomised controlled trials of ChAdOx1 nCoV-19 and who had previously received a single dose or two doses of 5 × 1010 viral particles are used for comparison purposes. COV001 is registered with ClinicalTrials.gov, NCT04324606, and ISRCTN, 15281137, and COV002 is registered with ClinicalTrials.gov, NCT04400838, and ISRCTN, 15281137, and both are continuing but not recruiting., Findings: Between March 11 and 21, 2021, 90 participants were enrolled in the third-dose boost substudy, of whom 80 (89%) were assessable for reactogenicity, 75 (83%) were assessable for evaluation of antibodies, and 15 (17%) were assessable for T-cells responses. The two-dose cohort comprised 321 participants who had reactogenicity data (with prime-boost interval of 8-12 weeks: 267 [83%] of 321; 15-25 weeks: 24 [7%]; or 44-45 weeks: 30 [9%]) and 261 who had immunogenicity data (interval of 8-12 weeks: 115 [44%] of 261; 15-25 weeks: 116 [44%]; and 44-45 weeks: 30 [11%]). 480 participants from the single-dose cohort were assessable for immunogenicity up to 44-45 weeks after vaccination. Antibody titres after a single dose measured approximately 320 days after vaccination remained higher than the titres measured at baseline (geometric mean titre of 66·00 ELISA units [EUs; 95% CI 47·83-91·08] vs 1·75 EUs [1·60-1·93]). 32 participants received a late second dose of vaccine 44-45 weeks after the first dose, of whom 30 were included in immunogenicity and reactogenicity analyses. Antibody titres were higher 28 days after vaccination in those with a longer interval between first and second dose than for those with a short interval (median total IgG titre: 923 EUs [IQR 525-1764] with an 8-12 week interval; 1860 EUs [917-4934] with a 15-25 week interval; and 3738 EUs [1824-6625] with a 44-45 week interval). Among participants who received a third dose of vaccine, antibody titres (measured in 73 [81%] participants for whom samples were available) were significantly higher 28 days after a third dose (median total IgG titre: 3746 EUs [IQR 2047-6420]) than 28 days after a second dose (median 1792 EUs [IQR 899-4634]; Wilcoxon signed rank test p=0·0043). T-cell responses were also boosted after a third dose (median response increased from 200 spot forming units [SFUs] per million peripheral blood mononuclear cells [PBMCs; IQR 127-389] immediately before the third dose to 399 SFUs per milion PBMCs [314-662] by day 28 after the third dose; Wilcoxon signed rank test p=0·012). Reactogenicity after a late second dose or a third dose was lower than reactogenicity after a first dose., Interpretation: An extended interval before the second dose of ChAdOx1 nCoV-19 leads to increased antibody titres. A third dose of ChAdOx1 nCoV-19 induces antibodies to a level that correlates with high efficacy after second dose and boosts T-cell responses., Funding: UK Research and Innovation, Engineering and Physical Sciences Research Council, National Institute for Health Research, Coalition for Epidemic Preparedness Innovations, National Institute for Health Research Oxford Biomedical Research Centre, Chinese Academy of Medical Sciences Innovation Fund for Medical Science, Thames Valley and South Midlands NIHR Clinical Research Network, AstraZeneca, and Wellcome., Competing Interests: Declaration of interests SCG and AVSH are cofounders of and shareholders in Vaccitech (collaborators in the early development of ChAdOx1 nCoV-19) and named as inventors on a patent covering use of ChAdOx1-vectored vaccines (PCT/GB2012/000467) and a patent application covering this SARS-CoV-2 vaccine (SCG only). TL is named as an inventor on a patent covering use of ChAdOx1-vectored vaccines (PCT/GB2012/000467) and was a consultant to Vaccitech. PMF is a consultant to Vaccitech. AJP is chair of the UK Department of Health and Social Care's Joint Committee on Vaccination and Immunisation, but does not participate in policy advice on coronavirus vaccines, and is a member of the WHO Strategic Advisory Group of Experts (SAGE). AJP is an NIHR Senior Investigator. All other authors declare no competing interests., (Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)- Published
- 2021
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.