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22 results on '"Abohelaika, Salah"'

1. Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients

Author

Alomar, Fadhel A., Alshakhs, Marai N., Abohelaika, Salah, Almarzouk, Hassan M., Almualim, Mohammed, Al-Ali, Amein K., Al-Muhanna, Fahad, Alomar, Mohammed F., Alhaddad, Mousa J., Almulaify, Mohammed S., Alessa, Faisal S., Alsalman, Ahmed S., Alaswad, Ahmed, Bidasee, Sean R., Alsaad, Hassan A., Alali, Rudaynah A., AlSheikh, Mona H., Akhtar, Mohammed S., Al Mohaini, Mohammed, Alsalman, Abdulkhaliq J., Alturaifi, Hussain, and Bidasee, Keshore R.

Published
2022
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2. Methylglyoxal and Its Role in Obesity-Associated Heart Failure with Preserved Ejection Fraction

Author

Alomar, Fadhel A., Moore, Caronda J., Abohelaika, Salah, Al-Muhanna, Fahad, Alshabeed, Mohammed A., Hamel, Frederick, DeSouza, Cyrus, Bidasee, Keshore R., Dhalla, Naranjan S., Series Editor, Bolli, Roberto, Editorial Board Member, Goyal, Ramesh, Editorial Board Member, Kartha, Chandrasekharan, Editorial Board Member, Kirshenbaum, Lorrie, Editorial Board Member, Makino, Naoki, Editorial Board Member, Mehta, Jawahar L. L., Editorial Board Member, Ostadal, Bohuslav, Editorial Board Member, Pierce, Grant N., Editorial Board Member, Slezak, Jan, Editorial Board Member, Varro, Andras, Editorial Board Member, Werdan, Karl, Editorial Board Member, Weglicki, William B., Editorial Board Member, Tappia, Paramjit S., editor, and Ramjiawan, Bram, editor

Published
2021
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3. Incidence of Surgical Site Infection Following Cesarean Section and Its Associated Factors in a Hospital of the Eastern Region, Saudi Arabia: A Retrospective Cohort Study.

Author

Albaharnah, Sukinah F., Rashed, Sara A., Almuhaimeed, Rahaf S., and Abohelaika, Salah

Subjects
CESAREAN section, RISK assessment, MATERNAL health services, BODY mass index, LOGISTIC regression analysis, HOSPITALS, RETROSPECTIVE studies, DESCRIPTIVE statistics, SURGICAL complications, LONGITUDINAL method, ODDS ratio, MEDICAL records, ACQUISITION of data, SURGICAL site infections, DATA analysis software, CONFIDENCE intervals, DISEASE incidence, COMORBIDITY, DISEASE risk factors
Abstract

Background: Surgical site infections (SSIs) following cesarean sections (CS) pose significant challenges in healthcare settings, prompting this five-year investigation in a Qatif Area general hospital. The study aimed to delineate nuances in SSI occurrences, assess yearly variations, and identify associated risk factors impacting SSI rates among CS patients. Methods: A retrospective analysis of 1584 cesarean sections conducted over five years was undertaken, and the reported SSI cases were examined to calculate the overall and yearly SSI rates. The impact of potential risk factors such as diabetes mellitus, hypertension, and postoperative antibiotic courses on SSI occurrence was examined. Results: The study revealed an overall SC rate of 15.4%. The SSI rate following CS was 4.7% (N = 74), with variations across years ranging from 2.2% in 2020 to a peak of 6.7% in 2022. Notably, 2021 and 2022 demonstrated increased SSI rates compared to prior years. Diabetes mellitus and a surgery duration of more than one hour exhibited a substantial association with SSI occurrence, (OR = 10.76, p = 0.038) and (OR = 3.54, p = 0.002), respectively, signifying independent risk factors. Conclusions: The study underscores the dynamic nature of SSI rates following CS, highlighting an increasing trend in recent years. All cases were managed with the optimal hospital care. Diabetes mellitus and a surgery duration of more than one hour emerged as prominent independent risk factors for SSI, warranting heightened vigilance and tailored preventive measures in this subset of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Factors affecting the safe use of oral anticoagulants

Author

Abohelaika, Salah Ahmed O.

Subjects
615.7
Abstract

The aim of this PhD was to elucidate the factors that influence anticoagulation response to the oral anticoagulants, warfarin and non-vitamin K antagonist oral anticoagulants (NOACs). Identification of the factors which influence clinical response to these agents could lead to improvements in patient management and treatment safety. In a cross-sectional study, the mean TTR over a 12 months period was significantly higher in hospital monitored patients (78%) (P=0.001) compared to those monitored in general practice (71%) or at their homes (68%). Domiciliary monitored patients had the least TTR among the three groups although they had the highest numbers of dose changes and INR monitoring events. In a further longitudinal study of patients on warfarin for up to 14 years, the TTR according to age was significantly lower in home monitored patients, with this group having a higher probability of having poor anticoagulation control (TTR ≤65%). In an ex-vivo study, rivaroxaban in vitamin K deficient older subjects produced a greater prolongation of both PT and modified PT, and a greater suppression in the rate and amount of thrombin generation compared to vitamin K replete younger subjects. Therefore, poor vitamin K intake could play a role in the reported incidences of bleeding associated with NOACs We had previously demonstrated that daily vitamin K supplementation causes an increase in warfarin daily dose requirement which varies between different patients and is related to VKORC1 genotype. Based upon these observations we set out to test our hypothesis that patients on warfarin therapy with the VKORC1(-1639)GG polymorphism could have poorer anticoagulation control than those with GA or AA genotypes as a result of variable dietary intake of vitamin K. However, the study results failed to confirm this hypothesis. Patients on warfarin therapy scheduled for an invasive surgery have to stop taking the drug for a fixed number of days to avoid peri-operative bleeding. However, there is variance in the rate by which INR falls after stopping warfarin. I found that patients with CYP2C9 variant alleles (CYP2C9*2*2 or CYP2C9*2*3) were >8 times (95% CI = 2.25–33.25) more likely to have INR of ≥ 1.5 before the planned day of surgery than those with wild-type genotype. In a further study, patient age and CYP2C9 *2*2 & *2*3 ii genotype were found to significantly influence the time required to reach an INR of 1.5 following warfarin cessation. VKORC1 genotype had no effect on the rate of INR decline.

Published
2017

10. Elevated Plasma Level of the Glycolysis Byproduct Methylglyoxal on Admission Is an Independent Biomarker of Mortality in ICU COVID-19 Patients

Author

Alomar, Fadhel A., primary, Alshakhs, Marai N., additional, Abohelaika, Salah, additional, Almarzouk, Hassan M., additional, Almualim, Mohammed, additional, Al-Ali, Amein K., additional, Al-Muhanna, Fahad, additional, Alomar, Mohammed F., additional, Alhaddad, Mousa J., additional, Almulaify, Mohammed S., additional, Alessa, Faisal S., additional, Alsalman, Ahmed S., additional, Alaswad, Ahmed, additional, Bidasee, Sean R., additional, Alsaad, Hassan, additional, Alali, Rudaynah A, additional, AlSheikh, Mona H., additional, Akhtar, Mohammed S., additional, Mohaini, Mohammed Al, additional, Alsalman, Abdulkhaliq J., additional, Alturaifi, Hussain, additional, and Bidasee, Keshore R., additional

Published
2021
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19. Individual and monitoring centre influences upon anticoagulation control of AF patients on warfarin: A longitudinal multi-centre UK-based study

Author

Abohelaika, Salah, primary, Wynne, Hilary, additional, Avery, Peter, additional, Robinson, Brian, additional, Jones, Lisa, additional, Tait, Campbell, additional, Dickinson, Bradley, additional, Salisbury, Julie, additional, Nightingale, Joanna, additional, Green, Louise, additional, and Kamali, Farhad, additional

Published
2018
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