1. Pathological remodeling of myocardium in spontaneous hypertensive rats with experimental diabetes mellitus: the role of mitochondrial dysfunction
- Author
-
Kolesnyk MIu, Abramov Av, and Kolesnyk IuM
- Subjects
Experimental Diabetes Mellitus ,medicine.medical_specialty ,biology ,Physiology ,business.industry ,Mitochondrion ,medicine.disease ,Endocrinology ,Mitochondrial permeability transition pore ,Annexin ,Diabetes mellitus ,Internal medicine ,cardiovascular system ,medicine ,biology.protein ,Titin ,business ,Pathological ,Type I collagen - Abstract
The expression of cardiotrophin-1, annexin V, titin and type I collagen was investigated in myocardium of normotensive Wistar rats and spontaneous hypertensive rats with and without experimental diabetes. The Ca(2+)-induced mitochondrial permeability transition pore was assessed in mitochondria isolated from rat hearts. The contents of cardiotrophin-1, annexin V and type I collagen in spontaneous hypertensive rats with diabetes were higher compared with that detected in the groups of normotensive rats and rats with diabetes. The cardiac titin level was 27% lower in animals with hypertension and diabetes compared to spontaneous hypertensive rats without diabetes. The changes of cardiotrophin-1, annexin V, titin and type I collagen expression were associated with higher sensitivity of mitochondrial pore to Ca2+ in myocardium of spontaneous hypertensive rats with diabetes.
- Published
- 2014