1. Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers
- Author
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Muhie, Seid, Gautam, Aarti, Yang, Ruoting, Misganaw, Burook, Daigle, Bernie J, Mellon, Synthia H, Flory, Janine D, Abu-Amara, Duna, Lee, Inyoul, Wang, Kai, Rampersaud, Ryan, Consortium, PTSD Systems Biology, Hood, Leroy, Yehuda, Rachel, Marmar, Charles R, Wolkowitz, Owen M, Ressler, Kerry J, Doyle, Francis J, Hammamieh, Rasha, and Jett, Marti
- Subjects
Post-Traumatic Stress Disorder (PTSD) ,Mental Health ,Anxiety Disorders ,Brain Disorders ,Biotechnology ,Clinical Research ,Genetics ,Good Health and Well Being ,Humans ,Military Personnel ,Veterans ,Stress Disorders ,Post-Traumatic ,Proteomics ,Inflammation ,PTSD Systems Biology Consortium ,active duty ,angiogenesis ,inflammatory response ,metabolic dysregulation ,molecular signature ,multi-omics ,oxidative stress ,post-traumatic stress disorder ,veterans ,wound healing ,metabolic imbalance - Abstract
Post-traumatic stress disorder (PTSD) is a multisystem syndrome. Integration of systems-level multi-modal datasets can provide a molecular understanding of PTSD. Proteomic, metabolomic, and epigenomic assays are conducted on blood samples of two cohorts of well-characterized PTSD cases and controls: 340 veterans and 180 active-duty soldiers. All participants had been deployed to Iraq and/or Afghanistan and exposed to military-service-related criterion A trauma. Molecular signatures are identified from a discovery cohort of 218 veterans (109/109 PTSD+/-). Identified molecular signatures are tested in 122 separate veterans (62/60 PTSD+/-) and in 180 active-duty soldiers (PTSD+/-). Molecular profiles are computationally integrated with upstream regulators (genetic/methylation/microRNAs) and functional units (mRNAs/proteins/metabolites). Reproducible molecular features of PTSD are identified, including activated inflammation, oxidative stress, metabolic dysregulation, and impaired angiogenesis. These processes may play a role in psychiatric and physical comorbidities, including impaired repair/wound healing mechanisms and cardiovascular, metabolic, and psychiatric diseases.
- Published
- 2023