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Purpose: To compare bone substitutes composed of glycated collagen with synthetic micro-sized (1 to 10 µm) hydroxyapatite (OB) vs non-cross-linked collagen matrix with large-particle (250 to 1,000 µm) bovine-derived hydroxyapatite (BOC). Materials and Methods: The P1 to P4 premolars were bilaterally extracted from the mandibles of 19 Beagle dogs. After 21 days, osteotomies were created in each dog that received OB or BOC and were covered with a collagen membrane or were left untreated. The animals were randomly divided into three groups based on sacrifice time (4, 12, or 24 weeks). The right and left hemimandibles were trimmed to facilitate imaging and histology, and all tissues were placed in 10% neutral-buffered formalin. Microcomputed tomography (MicroCT 40 Scanner, Scanco) was used to analyze bone sections. Bone volume, residual material volume, and bone mineral density were determined for each treatment site (OB and BOC) based on a volume of interest that encompassed the original defect. Additionally, blinded histopathologic assessment (based on the ISO 10993-6 scoring system) and histomorphometry were performed on sections ground to < 100 µm thick and stained with Stevenel's blue. Results: No clinical side effects were noted. No statistical differences were observed for OB vs BOC regarding the mineral volume percentage. Compared to OB, BOC had significantly higher mean mineralization densities at 12 weeks (P < .01), but this difference did not extend to 24 weeks. For residual grafting material, bone maturation, alveolar ridge restoration, and inflammatory response, OB showed a residual amount of bone graft and no statistical differences compared to BOC. Conclusion: Both OB and BOC represent valid treatment options for critically sized bone defects. Both bone fillers outperformed the sham-operated, ungrafted (empty) control, demonstrating statistically improved bone growth and ridge restoration. [ABSTRACT FROM AUTHOR]

Purpose: To compare glycated multilayered membranes (OV) to a commercially available thin-layer membrane (OP) in a lateral ridge augmentation model in dogs. Materials and Methods: This was designed as a three-arm study, where one negative control (empty defect) was compared to two test arms: alveolar bone defects grafted with a mixture of 90% deproteinized bovine bone mineral and 10% porcine collagen, then covered with either a thick- (OV) or thin-layered (OP) membrane. Animals were randomly divided into three groups corresponding to the final sacrifice times of 4 weeks, 12 weeks, and 24 weeks. Sections underwent microCT, histology, histopathology, and histomorphometry. Results: No statistical differences were observed for OV compared to OP regarding the percentage of mineral volume and mean mineral density, amount of bone maturation, percentage of bone graft and membrane remaining in the grafted area, alveolar ridge width measurements, membrane mineralization, or ossification. Test groups presented significantly higher values compared to the empty control for all the endpoints. Conclusions: Within its limitations, this in vivo study highlighted that multilayered thick glycated membranes can serve as effective occlusive barriers for up to 6 months. [ABSTRACT FROM AUTHOR]

Placement of short implants is a common approach to rehabilitate edentulous areas. The objective of this study was to evaluate the long-term survival of 7.0- and 8.5-mm implants placed in either a delayed or immediate loading protocol. Life table analysis revealed the implants treated with the delayed loading protocol had a 90.9% survival rate and the implants treated with the immediate loading protocol had a survival rate of 92.0%. The results of this 8-year prospective study demonstrate similar survival rates of short, cylindrical threaded implants placed by either a delayed or immediate loading protocol. [ABSTRACT FROM AUTHOR]

Treatments for enhancing surface energy were studied in an effort to create a more favorable environment for cell adhesion. Cold argon plasma (CAP) is able to improve titanium-cell contact, producing hydrophilic surfaces with higher wettability. The aim of this in vitro study was to estimate the early cell morphology after CAP treatment of different commercially available titanium surfaces. Surface wettability was significantly augmented in all the treated samples. The authors investigated how CAP affected the behavior of osteoblasts by evaluating the cell morphology outcome. Cell surface areas differed in a statistically significant way when plasma-treated samples were compared to the untreated ones. The positive effect of CAP was shown on smooth, moderately rough, and rough implant surfaces. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this ongoing prospective study was to determine the 5-year survival rate of short porous dental implants in the posterior atrophic maxilla combined, when necessary, with crestal sinus floor elevation and often adding an organic bovine bone.Materials and methods: In 87 partially edentulous patients, 110 short porous implants were placed and followed up for 5 years. The implants used were of two lengths (5 and 7 mm) and two diameters(4.1 and 5 mm) and were chosen according to the available crestal height and width. In 47 sites,osteotome sinus floor elevation was performed (in 8 cases compacting basal bone, in 39 adding a xenograft). The unloaded healing period was 6 months. A total of 63 implants were restored with single crowns and 47 were splinted to the adjacent implants. Outcome measures were prosthesis and implant failures, any complications, and peri-implant marginal bone resorption.Results: Five years after loading, no patients dropped out. Eleven implants failed: 2 implants at uncovering and 9 after prosthetic loading. Eleven patients (12.6%) lost 1 implant. In 6 patients(6.9%) a prosthesis failure occurred (implants loaded with single crowns). One surgical complication(membrane perforation) occurred but the implant was normally inserted. No complicationsoccurred during the healing period. In 3 patients, severe peri-implantitis occurred post loading and the implants had to be removed. Two abutments became loose and one crown chipped. At the end of the follow-up period the implant survival rate was 90%, and 93.1% with regard to prostheticreconstruction. The mean peri-implant marginal bone loss was 1.4 mm.Conclusions: The use of short porous implants showed an acceptable clinical outcome in the treatment of the posterior maxilla in this interim 5-year report. Longer follow-ups are needed to confirm these results.Conflict-of-interest statement: The authors declare no conflict of interest. All of the materials and implants were purchased and paid for by the dental clinic. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this ongoing prospective study was to determine the 5-year survival rate of short porous implants in the posterior atrophic mandible.Materials and methods: In 40 partially edentulous patients, 55 short porous implants were placed.The implants used were of two lengths (5 and 7 mm) and two different diameters (4.1 and 5 mm) and were chosen according to the available crestal height and width. The unloaded healing period was 4 months. Twenty-one implants were restored with single crowns, 32 were splinted to the adjacent implant, 2 were used with an overdenture and were followed for 5 years. Outcome measures were prosthesis failures, implant failures and complications.Results: No patients dropped out. Nine implants were removed: 1 implant at uncovering and 8 after prosthetic loading. Eight patients lost 1 implant and 1 patient lost 2 implants. Four crowns failed. No complications occurred during the healing period. In 2 patients severe peri-implantitis occurred after loading and the implants had to be removed. At the end of the follow-up period the survival rate was 84% at implant level and 80% at patient level.Conclusions: The use of short porous implants showed an acceptable clinical outcome in the treatment of the posterior mandible in this interim 5-year report. These preliminary results must be confirmed by longer follow-ups. [ABSTRACT FROM AUTHOR]

Root coverage is the goal of periodontal plastic surgery when treating gingival recessions. The aim of the present study was to evaluate the clinical results 1 year after treatment with an envelope connective tissue graft technique for single recessions. Forty consecutive patients with single recessions were treated. At baseline and 1 year after surgery, recession, probing pocket depth, clinical attachment level, and keratinized tissue height were recorded. After 1 year, the mean differences in recession (3.12 ± 0.90 mm), clinical attachment level (3.92 ± 1.00 mm), keratinized tissue height (3.75 ± 0.95 mm), and probing pocket depth (0.50 ± 0.64 mm) were statistically significant. Mean root coverage was 95.54% ± 11.43%; 85% of the treated cases achieved complete root coverage. The envelope connective tissue graft technique showed high predictability in the treatment of single recessions. [ABSTRACT FROM AUTHOR]

The aim of this ongoing prospective study was to determine the 36-month survival rate of short porous implants in the posterior maxilla with 2 to 7 mm of initial bone height in 48 patients. Forty-eight implants were placed; 35 were in sites with a bone height of 5 mm or less and 13 patients required sinus elevation with osteotomes in addition to a xenograft. All implants were loaded with single crowns. At the end of the follow-up period the survival rate was 97.92%. The use of short porous implants showed good predictability in the treatment of the posterior maxilla in this interim 3-year report. [ABSTRACT FROM AUTHOR]

Aim: To evaluate the amount of apical root resorption of central incisors with periodontal involvement in patients undergoing orthodontic intrusion. Methods: Twenty-eight adult periodontal patients were treated with combined orthodontic-periodontic therapy. After open-flap surgery, the orthodontic treatment started, following the segmented arch technique, and the teeth were intruded. The amount of radicular resorption was evaluated on standardized intraoral radiographs. The influence of intrusion, treatment time, and age and gender of the patients upon apical resorption were also studied. Results: At the end of treatment, mean resorption at the apex was 0.46 mm, 3.46% of the initial root length. No relationship was found between resorption and amount of intrusion or patient gender and age. A poor level of association was reported between resorption and treatment duration. Conclusion: Results suggest that by using light (10 to 15 g) and continuous forces, apical resorption could be kept to a minimum. This also is true in the treatment of maxillary central incisors with marginal bone loss. [ABSTRACT FROM AUTHOR]

Clinicians often encounter osseous defects that are best treated by conventional surgical techniques, including bone grafting and guided tissue regeneration, with a goal of establishing a new connective tissue attachment. On occasion, the recognition of an infrabony defect proximal to a tooth with a large diastema may present an opportunity to consider resolution by orthodontic tooth movement. Ideally, the tooth could be moved in the proximal direction until there was no further radiographic or clinical evidence of the predisposing defect. The authors decided to treat an advanced case of adult periodontitis, with extrusion and migration of a maxillary central incisor, using a multidisciplinary approach. Radiologically, a large infrabony defect was present on the mesial aspect of the incisor, with an initial probing depth of 9 mm. After the surgical periodontal therapy, the orthodontic movement started and the incisor was repositioned using an intrusive mechanism, also leading to the closure of the diastema. At the end of the treatment, there was a significant clinical decrease in the probing depth values, and radiographs showed a remarkable reduction of the infrabony defect volume. [ABSTRACT FROM AUTHOR]

Periodontal disease can lead to migration of anterior teeth with the presence of infrabony defects. This creates the opportunity for treating such patients with a combined orthodontic-periodontic treatment. In the presented clinical case, an adult periodontal patient with extrusion of the maxillary central incisors and an infrabony defect on their lingual aspects was treated. During the surgical procedure, the bone defects were augmented with a combination of porous bovine bone mineral (Bio-Oss) and a fibrin-fibronectin sealing system (Tissucol). Ten days after surgery, the active orthodontic treatment started, and the teeth were intruded and realigned, moving the roots into the defects. After 6 months, the orthodontic appliances were removed and the teeth were retained by means of a resin-bonded splint. At this time, reduction in probing pocket depth and gingival recession was detected. Twelve months after the initial surgery, a reentry procedure was performed, showing complete filling of the predisposing defects with the presence of bone-like hard tissue. These clinical results suggest that teeth can be successfully moved and intruded into bone defects previously augmented with bovine bone substitute and fibrin glue. During the orthodontic treatment, this combined augmentation material was able to be replaced by bone-like hard tissue. At the end of the therapy, an improvement in esthetics and periodontal health status was registered. [ABSTRACT FROM AUTHOR]

In the present study, 139 periodontally compromised patients received a complete periodontal treatment; in 104 cases this was followed by orthodontic treatment. At the end of the entire therapy, a total of 150 Maryland restorations (69 resin-bonded fixed partial dentures and 81 resin-bonded splints) was placed and then followed for a period of up to 10 years (mean 6.7 y). Thirteen fixed partial dentures and 16 splints failed during the observation period; the 10-year cumulative survival rate from lifetable analysis was 76.2% (70.6% for fixed partial dentures and 80.7% for splints). [ABSTRACT FROM AUTHOR]

This investigation evaluated the predictability of dental implants subjected to bone regeneration procedures at the time of insertion. Fifty-two test implants were inserted into sites with periimplant bone defects. A calcium carbonate allograft material with or without a fibrin-fibronectin sealing system was used to fill the defects. Sixty control implants were inserted into an adequate volume of nonaugmented bone. Each of the 29 study patients received at least one test implant and one control implant. At the second-stage surgery, fill of the bone defect was assessed as complete or incomplete. The cumulative success rate was 91.7% (mean follow-up 55 mo) for the test implants and 93.2% (mean follow-up 59 mo) for the control implants. Within the test group, implants with complete bone fill achieved 97.6% success versus 59.1% success for implants with incomplete bone fill. These preliminary results suggest that implants placed with simultaneous bone regeneration procedures achieve long-term predictability that is comparable to that of implants placed in an adequate volume of bone, provided that complete bone fill of the periimplant defect is achieved. Long-term studies with other augmentation materials are needed to fully validate these findings. [ABSTRACT FROM AUTHOR]

This work describes the therapeutic protocol of combined orthodontic-periodontal treatment and evaluates the effectiveness of surgical and nonsurgical periodontal therapy in the maintenance of a healthy periodontal status after the orthodontic treatment. Surgical periodontal treatment was performed in 267 patients affected by severe periodontal disease, and 128 patients had nonsurgical treatment. For each patient the mean value of probing depth (mPPD) and the rate of positive bleeding on probing (%BoP) of the teeth involved in the orthodontic movement were registered before the start of the periodontal treatment, at the end of the orthodontic treatment, and 2, 4,6, 10, and 12 years after the end of the orthodontic treatment. Comparison between pretreatment and posttreatment values and between pretreatment and follow-up values showed a decrease in mPPD and %BoP that was of statistical significance. The difference between posttreatment and follow-up values was not statistically significant. These results suggest that orthodontic treatment is no longer a contraindication in the therapy of severe adult periodontitis. In these cases orthodontics improve the possibilities of saving and restoring a deteriorated dentition. [ABSTRACT FROM AUTHOR]

This study evaluated a new surgical technique for the treatment of an alveolar ridge deficiency in 11 patients. Twenty two implants were placed, 15 of which presented with a combination of supracrestal and dehiscence kinds of defects, and seven presented only supracrestal bone loss. Surgical procedures were performed utilizing a combination of the resorbable spacemaking material calcium carbonate stabilized with a fibrin-fibronectin sealing system and the immediate placement of titanium dental implants. After implant placement, the mean height for supracrestal and dehiscence defects measured 2.57 ± 1.41 mm and 2.47 ± 1.54 mm, respectively. The defects were filled with calcium carbonate and a fibrin-fibronectin sealing system, and the flaps were sutured, avoiding any compression of the treated area. Healing was uneventful in all instances. At second-stage surgery at 6 months, a hard bonelike tissue was detectable at the defect sites. Histolegic examination of four defects confirmed the presence of newly formed bone and revealed residual particles of calcium carbonate. There was a mean gain of 2.05 ± 1.47 mm in the supracrestal defects and of 2.23 ± 1.62 mm in the dehiscences. The results indicated that calcium carbonate, combined with a fibrin-fibronectin sealing system, is a viable alternative in the treatment of supracrestal and dehiscence bony defects. [ABSTRACT FROM AUTHOR]