14 results on '"Acevedo, Claudio T."'
Number of results to display per page
Search Results
2. Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms
- Author
-
Deforth, Manja; https://orcid.org/0000-0002-1111-1799, Gebhard, Caroline E; https://orcid.org/0000-0003-4975-2679, Bengs, Susan; https://orcid.org/0000-0003-2424-3894, Buehler, Philipp K; https://orcid.org/0000-0003-4690-9896, Schuepbach, Reto A; https://orcid.org/0000-0002-7058-4377, Zinkernagel, Annelies S; https://orcid.org/0000-0003-4700-1118, Brugger, Silvio D; https://orcid.org/0000-0001-9492-9088, Acevedo, Claudio T; https://orcid.org/0000-0002-3624-9401, Patriki, Dimitri; https://orcid.org/0000-0001-6364-0927, Wiggli, Benedikt, Twerenbold, Raphael; https://orcid.org/0000-0003-3814-6542, Kuster, Gabriela M, Pargger, Hans, Schefold, Joerg C, Spinetti, Thibaud, Wendel-Garcia, Pedro D; https://orcid.org/0000-0001-7775-3279, Hofmaenner, Daniel A; https://orcid.org/0000-0002-9334-7753, Gysi, Bianca, Siegemund, Martin, Heinze, Georg, Regitz-Zagrosek, Vera; https://orcid.org/0000-0002-3566-3467, Gebhard, Catherine; https://orcid.org/0000-0001-7240-5822, Held, Ulrike; https://orcid.org/0000-0003-3105-5840, Deforth, Manja; https://orcid.org/0000-0002-1111-1799, Gebhard, Caroline E; https://orcid.org/0000-0003-4975-2679, Bengs, Susan; https://orcid.org/0000-0003-2424-3894, Buehler, Philipp K; https://orcid.org/0000-0003-4690-9896, Schuepbach, Reto A; https://orcid.org/0000-0002-7058-4377, Zinkernagel, Annelies S; https://orcid.org/0000-0003-4700-1118, Brugger, Silvio D; https://orcid.org/0000-0001-9492-9088, Acevedo, Claudio T; https://orcid.org/0000-0002-3624-9401, Patriki, Dimitri; https://orcid.org/0000-0001-6364-0927, Wiggli, Benedikt, Twerenbold, Raphael; https://orcid.org/0000-0003-3814-6542, Kuster, Gabriela M, Pargger, Hans, Schefold, Joerg C, Spinetti, Thibaud, Wendel-Garcia, Pedro D; https://orcid.org/0000-0001-7775-3279, Hofmaenner, Daniel A; https://orcid.org/0000-0002-9334-7753, Gysi, Bianca, Siegemund, Martin, Heinze, Georg, Regitz-Zagrosek, Vera; https://orcid.org/0000-0002-3566-3467, Gebhard, Catherine; https://orcid.org/0000-0001-7240-5822, and Held, Ulrike; https://orcid.org/0000-0003-3105-5840
- Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic demands reliable prognostic models for estimating the risk of long COVID. We developed and validated a prediction model to estimate the probability of known common long COVID symptoms at least 60 days after acute COVID-19. Methods: The prognostic model was built based on data from a multicentre prospective Swiss cohort study. Included were adult patients diagnosed with COVID-19 between February and December 2020 and treated as outpatients, at ward or intensive/intermediate care unit. Perceived long-term health impairments, including reduced exercise tolerance/reduced resilience, shortness of breath and/or tiredness (REST), were assessed after a follow-up time between 60 and 425 days. The data set was split into a derivation and a geographical validation cohort. Predictors were selected out of twelve candidate predictors based on three methods, namely the augmented backward elimination (ABE) method, the adaptive best-subset selection (ABESS) method and model-based recursive partitioning (MBRP) approach. Model performance was assessed with the scaled Brier score, concordance c statistic and calibration plot. The final prognostic model was determined based on best model performance. Results: In total, 2799 patients were included in the analysis, of which 1588 patients were in the derivation cohort and 1211 patients in the validation cohort. The REST prevalence was similar between the cohorts with 21.6% (n = 343) in the derivation cohort and 22.1% (n = 268) in the validation cohort. The same predictors were selected with the ABE and ABESS approach. The final prognostic model was based on the ABE and ABESS selected predictors. The corresponding scaled Brier score in the validation cohort was 18.74%, model discrimination was 0.78 (95% CI: 0.75 to 0.81), calibration slope was 0.92 (95% CI: 0.78 to 1.06) and calibration intercept was -0.06 (95% CI: -0.22 to 0.09). Conclusion: The proposed model was validated to id
- Published
- 2022
3. Additional file 4 of Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms
- Author
-
Deforth, Manja, Gebhard, Caroline E., Bengs, Susan, Buehler, Philipp K., Schuepbach, Reto A., Zinkernagel, Annelies S., Brugger, Silvio D., Acevedo, Claudio T., Patriki, Dimitri, Wiggli, Benedikt, Twerenbold, Raphael, Kuster, Gabriela M., Pargger, Hans, Schefold, Joerg C., Spinetti, Thibaud, Wendel-Garcia, Pedro D., Hofmaenner, Daniel A., Gysi, Bianca, Siegemund, Martin, Heinze, Georg, Regitz-Zagrosek, Vera, Gebhard, Catherine, and Held, Ulrike
- Abstract
Additional file 4. Logistic regression model based on the ABE and ABESS variable selection, calculated on the total cohort.
- Published
- 2022
- Full Text
- View/download PDF
4. Assessing Antibiotic Tolerance of Staphylococcus aureus Derived Directly from Patients by the Replica Plating Tolerance Isolation System (REPTIS)
- Author
-
Herren, Sebastian C., primary, Huemer, Markus, additional, Acevedo, Claudio T., additional, Gómez-Mejia, Alejandro, additional, Andreoni, Federica, additional, Mairpady Shambat, Srikanth, additional, Hasse, Barbara, additional, Zbinden, Reinhard, additional, Brugger, Silvio D., additional, and Zinkernagel, Annelies S., additional
- Published
- 2022
- Full Text
- View/download PDF
5. Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients
- Author
-
Buehler, Philipp K., Zinkernagel, Annelies S., Hofmaenner, Daniel A., Wendel Garcia, Pedro David, Acevedo, Claudio T., Gómez-Mejia, Alejandro, Mairpady Shambat, Srikanth, Andreoni, Federica, Maibach, Martina A., Bartussek, Jan, Hilty, Matthias P., Frey, Pascal M., Schuepbach, Reto A., and Brugger, Silvio D.
- Published
- 2021
- Full Text
- View/download PDF
6. Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS
- Author
-
Wendel Garcia, Pedro David, primary, Hofmaenner, Daniel Andrea, additional, Brugger, Silvio D., additional, Acevedo, Claudio T., additional, Bartussek, Jan, additional, Camen, Giovanni, additional, Bader, Patrick Raphael, additional, Bruellmann, Gregor, additional, Kattner, Johannes, additional, Ganter, Christoph, additional, Schuepbach, Reto Andreas, additional, and Buehler, Philipp Karl, additional
- Published
- 2021
- Full Text
- View/download PDF
7. Supplemental Material, sj-pdf-1-jic-10.1177_08850666211024139 - Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS
- Author
-
Wendel Garcia, Pedro David, Hofmaenner, Daniel Andrea, Brugger, Silvio D., Acevedo, Claudio T., Bartussek, Jan, Camen, Giovanni, Bader, Patrick Raphael, Bruellmann, Gregor, Kattner, Johannes, Ganter, Christoph, Schuepbach, Reto Andreas, and Buehler, Philipp Karl
- Subjects
110203 Respiratory Diseases ,FOS: Clinical medicine ,111702 Aged Health Care ,FOS: Health sciences ,110305 Emergency Medicine - Abstract
Supplemental Material, sj-pdf-1-jic-10.1177_08850666211024139 for Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS by Pedro David Wendel Garcia, Daniel Andrea Hofmaenner, Silvio D. Brugger, Claudio T. Acevedo, Jan Bartussek, Giovanni Camen, Patrick Raphael Bader, Gregor Bruellmann, Johannes Kattner, Christoph Ganter, Reto Andreas Schuepbach and Philipp Karl Buehler in Journal of Intensive Care Medicine
- Published
- 2021
- Full Text
- View/download PDF
8. Blunted sFasL signalling exacerbates TNF‐driven neutrophil necroptosis in critically ill COVID‐19 patients
- Author
-
Schweizer, Tiziano A, Mairpady Shambat, Srikanth, Vulin, Clément, Hoeller, Sylvia, Acevedo, Claudio T, Huemer, Markus, Gómez-Mejia, Alejandro, Chang, Chun-Chi, Baum, Jeruscha, Hertegonne, Sanne, Hitz, Eva, Scheier, Thomas C, Hofmaenner, Daniel A, Buehler, Philipp K, Moch, Holger, Schuepbach, Reto A, Brugger, Silvio D, Zinkernagel, Annelies S, and University of Zurich
- Subjects
0303 health sciences ,RIPK1 ,Short Communication ,Immunology ,Short Communications ,necroptosis ,610 Medicine & health ,RC581-607 ,Fas (CD95) ,3. Good health ,10234 Clinic for Infectious Diseases ,03 medical and health sciences ,TNF‐α ,0302 clinical medicine ,neutrophils ,COVID‐19 ,10049 Institute of Pathology and Molecular Pathology ,030220 oncology & carcinogenesis ,Immunology and Allergy ,10023 Institute of Intensive Care Medicine ,Immunologic diseases. Allergy ,COVID 19 ,General Nursing ,030304 developmental biology - Abstract
Objectives Critically ill coronavirus disease 2019 (COVID‐19) patients are characterised by a severely dysregulated cytokine profile and elevated neutrophil counts, impacting disease severity. However, it remains unclear how neutrophils contribute to pathophysiology during COVID‐19. Here, we assessed the impact of the dysregulated cytokine profile on the regulated cell death (RCD) programme of neutrophils. Methods Regulated cell death phenotype of neutrophils isolated from critically ill COVID‐19 patients or healthy donors and stimulated with COVID‐19 or healthy plasma ex vivo was assessed by flow cytometry, time‐lapse microscopy and cytokine multiplex analysis. Immunohistochemistry of COVID‐19 patients and control biopsies were performed to assess the in situ neutrophil RCD phenotype. Plasma cytokine levels of COVID‐19 patients and healthy donors were measured by multiplex analysis. Clinical parameters were correlated to cytokine levels of COVID‐19 patients. Results COVID‐19 plasma induced a necroptosis‐sensitive neutrophil phenotype, characterised by cell lysis, elevated release of damage‐associated molecular patterns (DAMPs), increased receptor‐interacting serine/threonine‐protein kinase (RIPK) 1 levels and mixed lineage kinase domain‐like pseudokinase (MLKL) involvement. The occurrence of neutrophil necroptosis MLKL axis was further confirmed in COVID‐19 thrombus and lung biopsies. Necroptosis was induced by the tumor necrosis factor receptor 1 (TNFRI)/TNF‐α axis. Moreover, reduction of soluble Fas ligand (sFasL) levels in COVID‐19 patients and hence decreased signalling to Fas directly increased RIPK1 levels, exacerbated TNF‐driven necroptosis and correlated with disease severity, which was abolished in patients treated with glucocorticoids. Conclusion Our results suggest a novel role for sFasL signalling in the TNF‐α‐induced RCD programme in neutrophils during COVID‐19 and a potential therapeutic target to curb inflammation and thus influence disease severity and outcome., This work highlights the role of cell death ambiguity in neutrophils and its contribution to pathophysiology during critical COVID‐19. The inflammatory COVID‐19 environment provoked a TNF‐α‐induced necroptosis‐sensitive neutrophil subpopulation, characterised by elevated release of DAMPs, increased RIPK1 levels and a pivotal role for MLKL. Neutrophil necroptosis through the RIPK1‐RIPK3‐MLKL axis was further confirmed in COVID‐19 thrombus and lung biopsies. Blunted Fas engagement by sFasL was identified to drive elevated RIPK1 levels upon TNF‐α‐induced necroptosis, while decreased sFasL plasma levels in critically ill COVID‐19 patients correlated to elevated disease severity, which was masked by glucocorticoid treatment.
- Published
- 2021
9. Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients
- Author
-
Buehler, Philipp K; https://orcid.org/0000-0003-4690-9896, Zinkernagel, Annelies S; https://orcid.org/0000-0003-4700-1118, Hofmaenner, Daniel A; https://orcid.org/0000-0002-9334-7753, Wendel Garcia, Pedro David; https://orcid.org/0000-0001-7775-3279, Acevedo, Claudio T; https://orcid.org/0000-0002-3624-9401, Gómez-Mejia, Alejandro, Mairpady Shambat, Srikanth; https://orcid.org/0000-0002-0527-3978, Andreoni, Federica, Maibach, Martina A, Bartussek, Jan, Hilty, Matthias P; https://orcid.org/0000-0002-2765-881X, Frey, Pascal M; https://orcid.org/0000-0001-6161-0919, Schuepbach, Reto A; https://orcid.org/0000-0002-7058-4377, Brugger, Silvio D; https://orcid.org/0000-0001-9492-9088, Buehler, Philipp K; https://orcid.org/0000-0003-4690-9896, Zinkernagel, Annelies S; https://orcid.org/0000-0003-4700-1118, Hofmaenner, Daniel A; https://orcid.org/0000-0002-9334-7753, Wendel Garcia, Pedro David; https://orcid.org/0000-0001-7775-3279, Acevedo, Claudio T; https://orcid.org/0000-0002-3624-9401, Gómez-Mejia, Alejandro, Mairpady Shambat, Srikanth; https://orcid.org/0000-0002-0527-3978, Andreoni, Federica, Maibach, Martina A, Bartussek, Jan, Hilty, Matthias P; https://orcid.org/0000-0002-2765-881X, Frey, Pascal M; https://orcid.org/0000-0001-6161-0919, Schuepbach, Reto A; https://orcid.org/0000-0002-7058-4377, and Brugger, Silvio D; https://orcid.org/0000-0001-9492-9088
- Abstract
The impact of secondary bacterial infections (superinfections) in coronavirus disease 2019 (COVID-19) is not well understood. In this prospective, monocentric cohort study, we aim to investigate the impact of superinfections in COVID-19 patients with acute respiratory distress syndrome. Patients are assessed for concomitant microbial infections by longitudinal analysis of tracheobronchial secretions, bronchoalveolar lavages, and blood cultures. In 45 critically ill patients, we identify 19 patients with superinfections (42.2%). Superinfections are detected on day 10 after intensive care admission. The proportion of participants alive and off invasive mechanical ventilation at study day 28 (ventilator-free days [VFDs] at 28 days) is substantially lower in patients with superinfection (subhazard ratio 0.37; 95% confidence interval [CI] 0.15-0.90; p = 0.028). Patients with pulmonary superinfections have a higher incidence of bacteremia, virus reactivations, yeast colonization, and required intensive care treatment for a longer time. Superinfections are frequent and associated with reduced VFDs at 28 days despite a high rate of empirical antibiotic therapy.
- Published
- 2021
10. Assessing antibiotic tolerance ofStaphylococcus aureusderived directly from patients by the Replica Plating Tolerance Isolation System - REPTIS
- Author
-
Herren, Sebastian C., primary, Huemer, Markus, additional, Acevedo, Claudio T., additional, Andreoni, Federica, additional, Gómez-Mejia, Alejandro, additional, Shambat, Srikanth Mairpady, additional, Hasse, Barbara, additional, Zbinden, Reinhard, additional, Brugger, Silvio D., additional, and Zinkernagel, Annelies S., additional
- Published
- 2021
- Full Text
- View/download PDF
11. Capillary Leukocytes, Microaggregates, and the Response to Hypoxemia in the Microcirculation of Coronavirus Disease 2019 Patients
- Author
-
Favaron, Emanuele, primary, Ince, Can, additional, Hilty, Matthias P., additional, Ergin, Bülent, additional, van der Zee, Philip, additional, Uz, Zühre, additional, Wendel Garcia, Pedro D., additional, Hofmaenner, Daniel A., additional, Acevedo, Claudio T., additional, van Boven, Wim Jan, additional, Akin, Sakir, additional, Gommers, Diederik, additional, and Endeman, Henrik, additional
- Published
- 2021
- Full Text
- View/download PDF
12. Bacterial pulmonary superinfections are associated with unfavourable outcomes in critically ill COVID-19 patients
- Author
-
Buehler, Philipp K., primary, Zinkernagel, Annelies S., additional, Hofmaenner, Daniel A., additional, García, Pedro David Wendel, additional, Acevedo, Claudio T., additional, Gómez-Mejia, Alejandro, additional, Shambat, Srikanth Mairpady, additional, Andreoni, Federica, additional, Maibach, Martina A., additional, Bartussek, Jan, additional, Hilty, Matthias P., additional, Frey, Pascal M., additional, Schuepbach, Reto A., additional, and Brugger, Silvio D., additional
- Published
- 2020
- Full Text
- View/download PDF
13. Bacterial Pulmonary Superinfections Are Associated with Unfavourable Outcomes in Critically Ill COVID-19 Patients
- Author
-
Buehler, Philipp Karl, primary, Zinkernagel, Annelies S., additional, Hofmaenner, Daniel A., additional, Wendel Garcia, Pedro David, additional, Acevedo, Claudio T., additional, Gómez-Mejia, Alejandro, additional, Mairpady Shambat, Srikanth, additional, Andreoni, Federica, additional, Maibach, Martina A., additional, Bartussek, Jan, additional, Hilty, Matthias P., additional, Frey, Pascal M., additional, Schuepbach, Reto A., additional, and Brugger, Silvio D., additional
- Published
- 2020
- Full Text
- View/download PDF
14. Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS.
- Author
-
Garcia, Pedro David Wendel, Andrea Hofmaenner, Daniel, Brugger, Silvio D., Acevedo, Claudio T., Bartussek, Jan, Camen, Giovanni, Bader, Patrick Raphael, Bruellmann, Gregor, Kattner, Johannes, Ganter, Christoph, Schuepbach, Reto Andreas, and Buehler, Philipp Karl
- Subjects
ARTIFICIAL respiration ,COVID-19 pandemic ,LUNGS ,BODY weight ,CLINICAL trials - Abstract
Background: Lung-protective ventilation is key in bridging patients suffering from COVID-19 acute respiratory distress syndrome (ARDS) to recovery. However, resource and personnel limitations during pandemics complicate the implementation of lung-protective protocols. Automated ventilation modes may prove decisive in these settings enabling higher degrees of lungprotective ventilation than conventional modes. Method: Prospective study at a Swiss university hospital. Critically ill, mechanically ventilated COVID-19 ARDS patients were allocated, by study-blinded coordinating staff, to either closed-loop or conventional mechanical ventilation, based on mechanical ventilator availability. Primary outcome was the overall achieved percentage of lung-protective ventilation in closed-loop versus conventional mechanical ventilation, assessed minute-by-minute, during the initial 7 days and overall mechanical ventilation time. Lung-protective ventilation was defined as the combined target of tidal volume <8 ml per kg of ideal body weight, dynamic driving pressure <15 cmH
2 O, peak pressure <30 cmH2 O, peripheral oxygen saturation -88% and dynamic mechanical power <17 J/min. Results: Forty COVID-19 ARDS patients, accounting for 1,048,630 minutes (728 days) of cumulative mechanical ventilation, allocated to either closed-loop (n = 23) or conventional ventilation (n = 17), presenting with a median paO2 /FiO2 ratio of 92 [72-147] mmHg and a static compliance of 18 [11-25] ml/cmH2 O, were mechanically ventilated for 11 [4-25] days and had a 28-day mortality rate of 20%. During the initial 7 days of mechanical ventilation, patients in the closed-loop group were ventilated lung-protectively for 65% of the time versus 38% in the conventional group (Odds Ratio, 1.79; 95% CI, 1.76-1.82; P < 0.001) and for 45% versus 33% of overall mechanical ventilation time (Odds Ratio, 1.22; 95% CI, 1.21-1.23; P < 0.001). Conclusion: Among critically ill, mechanically ventilated COVID-19 ARDS patients during an early highpoint of the pandemic, mechanical ventilation using a closed-loop mode was associated with a higher degree of lung-protective ventilation than was conventional mechanical ventilation. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.