1. Potentiality of Marine Microbial Metabolites in the Remedy of Alzheimer's Disease: A Comprehensive Review.
- Author
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Paul, Srijita, Dey, Mouli, Roy, Bishnupriya, Dhara, Bikram, and Mitra, Arup Kumar
- Abstract
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders that leads to dementia among elderly. Formation of senile plaques in the brain by amyloid-β proteins and neurofibrillary tangles by hyper-phosphorylated tau proteins causing widespread damage to nerve cells, are characteristic features of AD. Secondary metabolites of potential biotechnological interests, isolated from marine microorganisms, exhibit anti-inflammatory, neuro-protective properties, which can be potentially exploited for treating AD. Possible mechanisms to counter AD, as demonstrated in various studies already conducted, include prevention of amyloid-β protein neurotoxicity by inhibiting multiple enzymes inducing apoptosis and activating genes that stimulate neuronal survival by fucoidan; inactivating acetylcholinesterase by phlorotannins along with inhibiting β site amyloid precursor protein cleaving enzyme 1 which is also exhibited by caniferolide A in addition to reducing neuro-inflammatory markers and Reactive oxygen species. Amyloid-β neuro-toxicity can be kept in check by the compound homotaurine which has high affinity for Gamma aminobutyric acid receptors and also by neoechinulin A. Spirolides, on the other hand, have been shown to exert positive consequences on AD biomarkers. Various other marine bacterial, fungal, algal metabolites also exhibit similar properties and have potential to be marketed as future drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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