Search

Your search keyword '"Acharya, Chaitanya R."' showing total 223 results
Start Over Author "Acharya, Chaitanya R."
223 results on '"Acharya, Chaitanya R."'

1. HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D, Acharya, Chaitanya R, Lubkov, Veronica, Mori, Hidetoshi, Boone, Peter G, Rochelle, Lauren K, Roberts, Wendy L, Everitt, Jeffrey I, Hartman, Zachary C, Crosby, Erika J, Barak, Lawrence S, Caron, Marc G, Chen, Jane Q, Hubbard, Neil E, Cardiff, Robert D, Borowsky, Alexander D, Lyerly, H Kim, and Snyder, Joshua C

Subjects
Breast Cancer, Cancer, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Animals, Breast Neoplasms, Carcinogenesis, Female, Gene Expression Regulation, Neoplastic, Mice, Mice, Knockout, Protein Isoforms, Receptor, ErbB-2, Tumor Microenvironment, Receptor, erbB-2, Oncology and Carcinogenesis, Developmental Biology, Oncology & Carcinogenesis
Abstract

HER2-positive breast cancers are among the most heterogeneous breast cancer subtypes. The early amplification of HER2 and its known oncogenic isoforms provide a plausible mechanism in which distinct programs of tumor heterogeneity could be traced to the initial oncogenic event. Here a Cancer rainbow mouse simultaneously expressing fluorescently barcoded wildtype (WTHER2), exon-16 null (d16HER2), and N-terminally truncated (p95HER2) HER2 isoforms is used to trace tumorigenesis from initiation to invasion. Tumorigenesis was visualized using whole-gland fluorescent lineage tracing and single-cell molecular pathology. We demonstrate that within weeks of expression, morphologic aberrations were already present and unique to each HER2 isoform. Although WTHER2 cells were abundant throughout the mammary ducts, detectable lesions were exceptionally rare. In contrast, d16HER2 and p95HER2 induced rapid tumor development. d16HER2 incited homogenous and proliferative luminal-like lesions which infrequently progressed to invasive phenotypes whereas p95HER2 lesions were heterogenous and invasive at the smallest detectable stage. Distinct cancer trajectories were observed for d16HER2 and p95HER2 tumors as evidenced by oncogene-dependent changes in epithelial specification and the tumor microenvironment. These data provide direct experimental evidence that intratumor heterogeneity programs begin very early and well in advance of screen or clinically detectable breast cancer. IMPLICATIONS: Although all HER2 breast cancers are treated equally, we show a mechanism by which clinically undetected HER2 isoforms program heterogenous cancer phenotypes through biased epithelial specification and adaptations within the tumor microenvironment.

Published
2021

3. A novel integrative risk index of papillary thyroid cancer progression combining genomic alterations and clinical factors

Author

Cheng, Qing, Li, Xuechan, Acharya, Chaitanya R, Hyslop, Terry, and Sosa, Julie Ann

Subjects
Biotechnology, Human Genome, Genetics, Cancer, Good Health and Well Being, Carcinoma, Carcinoma, Papillary, Disease Progression, Disease-Free Survival, Genomics, Humans, Prognosis, Risk Factors, Thyroid Cancer, Papillary, Thyroid Neoplasms, papillary thyroid cancer, disease progression, genomic alterations, clinical and pathologic factors, risk index model, Oncology and Carcinogenesis
Abstract

Although the majority of papillary thyroid cancer (PTC) is indolent, a subset of PTC behaves aggressively despite the best available treatment. A major clinical challenge is to reliably distinguish early on between those patients who need aggressive treatment from those who do not. Using a large cohort of PTC samples obtained from The Cancer Genome Atlas (TCGA), we analyzed the association between disease progression and multiple forms of genomic data, such as transcriptome, somatic mutations, and somatic copy number alterations, and found that genes related to FOXM1 signaling pathway were significantly associated with PTC progression. Integrative genomic modeling was performed, controlling for demographic and clinical characteristics, which included patient age, gender, TNM stages, histological subtypes, and history of other malignancy, using a leave-one-out elastic net model and 10-fold cross validation. For each subject, the model from the remaining subjects was used to determine the risk index, defined as a linear combination of the clinical and genomic variables from the elastic net model, and the stability of the risk index distribution was assessed through 2,000 bootstrap resampling. We developed a novel approach to combine genomic alterations and patient-related clinical factors that delineates the subset of patients who have more aggressive disease from those whose tumors are indolent and likely will require less aggressive treatment and surveillance (p = 4.62 × 10-10, log-rank test). Our results suggest that risk index modeling that combines genomic alterations with current staging systems provides an opportunity for more effective anticipation of disease prognosis and therefore enhanced precision management of PTC.

Published
2017

7. Movie 5 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

8. Supplementary Figure 2 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

9. Supplementary Figure 7 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

10. Supplementary Figure 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

11. Movie 2 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

12. Movie 3 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Tables 1-5 for scRNAseq marker genes from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

14. Data from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

15. Movie 4 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

16. Movie 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Figure 3 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

18. Supplementary Figure 5 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

19. Supplementary Figure 4 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure 6 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase

Author

Ginzel, Joshua D., primary, Acharya, Chaitanya R., primary, Lubkov, Veronica, primary, Mori, Hidetoshi, primary, Boone, Peter G., primary, Rochelle, Lauren K., primary, Roberts, Wendy L., primary, Everitt, Jeffrey I., primary, Hartman, Zachary C., primary, Crosby, Erika J., primary, Barak, Lawrence S., primary, Caron, Marc G., primary, Chen, Jane Q., primary, Hubbard, Neil E., primary, Cardiff, Robert D., primary, Borowsky, Alexander D., primary, Lyerly, H. Kim, primary, and Snyder, Joshua C., primary

Published
2023
Full Text
View/download PDF

21. Figure S2 from Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Author

Telli, Melinda L., primary, Nagata, Hiroshi, primary, Wapnir, Irene, primary, Acharya, Chaitanya R., primary, Zablotsky, Kaitlin, primary, Fox, Bernard A., primary, Bifulco, Carlo B., primary, Jensen, Shawn M., primary, Ballesteros-Merino, Carmen, primary, Le, Mai Hope, primary, Pierce, Robert H., primary, Browning, Erica, primary, Hermiz, Reneta, primary, Svenson, Lauren, primary, Bannavong, Donna, primary, Jaffe, Kim, primary, Sell, Jendy, primary, Foerter, Kellie Malloy, primary, Canton, David A., primary, Twitty, Christopher G., primary, Osada, Takuya, primary, Lyerly, H. Kim, primary, and Crosby, Erika J., primary

Published
2023
Full Text
View/download PDF

22. Supplementary methods from Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

Author

Crosby, Erika J., primary, Acharya, Chaitanya R., primary, Haddad, Anthony-Fayez, primary, Rabiola, Christopher A., primary, Lei, Gangjun, primary, Wei, Jun-Ping, primary, Yang, Xiao-Yi, primary, Wang, Tao, primary, Liu, Cong-Xiao, primary, Wagner, Kay U., primary, Muller, William J., primary, Chodosh, Lewis A., primary, Broadwater, Gloria, primary, Hyslop, Terry, primary, Shepherd, Jonathan H., primary, Hollern, Daniel P., primary, He, Xiaping, primary, Perou, Charles M., primary, Chai, Shengjie, primary, Ashby, Benjamin K., primary, Vincent, Benjamin G., primary, Snyder, Joshua C., primary, Force, Jeremy, primary, Morse, Michael A., primary, Lyerly, Herbert K., primary, and Hartman, Zachary C., primary

Published
2023
Full Text
View/download PDF

23. Figure S6 from Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

Author

Crosby, Erika J., primary, Acharya, Chaitanya R., primary, Haddad, Anthony-Fayez, primary, Rabiola, Christopher A., primary, Lei, Gangjun, primary, Wei, Jun-Ping, primary, Yang, Xiao-Yi, primary, Wang, Tao, primary, Liu, Cong-Xiao, primary, Wagner, Kay U., primary, Muller, William J., primary, Chodosh, Lewis A., primary, Broadwater, Gloria, primary, Hyslop, Terry, primary, Shepherd, Jonathan H., primary, Hollern, Daniel P., primary, He, Xiaping, primary, Perou, Charles M., primary, Chai, Shengjie, primary, Ashby, Benjamin K., primary, Vincent, Benjamin G., primary, Snyder, Joshua C., primary, Force, Jeremy, primary, Morse, Michael A., primary, Lyerly, Herbert K., primary, and Hartman, Zachary C., primary

Published
2023
Full Text
View/download PDF

24. Table S4 from Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Author

Telli, Melinda L., primary, Nagata, Hiroshi, primary, Wapnir, Irene, primary, Acharya, Chaitanya R., primary, Zablotsky, Kaitlin, primary, Fox, Bernard A., primary, Bifulco, Carlo B., primary, Jensen, Shawn M., primary, Ballesteros-Merino, Carmen, primary, Le, Mai Hope, primary, Pierce, Robert H., primary, Browning, Erica, primary, Hermiz, Reneta, primary, Svenson, Lauren, primary, Bannavong, Donna, primary, Jaffe, Kim, primary, Sell, Jendy, primary, Foerter, Kellie Malloy, primary, Canton, David A., primary, Twitty, Christopher G., primary, Osada, Takuya, primary, Lyerly, H. Kim, primary, and Crosby, Erika J., primary

Published
2023
Full Text
View/download PDF

25. Table S1 from Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

Author

Crosby, Erika J., primary, Acharya, Chaitanya R., primary, Haddad, Anthony-Fayez, primary, Rabiola, Christopher A., primary, Lei, Gangjun, primary, Wei, Jun-Ping, primary, Yang, Xiao-Yi, primary, Wang, Tao, primary, Liu, Cong-Xiao, primary, Wagner, Kay U., primary, Muller, William J., primary, Chodosh, Lewis A., primary, Broadwater, Gloria, primary, Hyslop, Terry, primary, Shepherd, Jonathan H., primary, Hollern, Daniel P., primary, He, Xiaping, primary, Perou, Charles M., primary, Chai, Shengjie, primary, Ashby, Benjamin K., primary, Vincent, Benjamin G., primary, Snyder, Joshua C., primary, Force, Jeremy, primary, Morse, Michael A., primary, Lyerly, Herbert K., primary, and Hartman, Zachary C., primary

Published
2023
Full Text
View/download PDF

26. Supplementary methods from Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Author

Telli, Melinda L., primary, Nagata, Hiroshi, primary, Wapnir, Irene, primary, Acharya, Chaitanya R., primary, Zablotsky, Kaitlin, primary, Fox, Bernard A., primary, Bifulco, Carlo B., primary, Jensen, Shawn M., primary, Ballesteros-Merino, Carmen, primary, Le, Mai Hope, primary, Pierce, Robert H., primary, Browning, Erica, primary, Hermiz, Reneta, primary, Svenson, Lauren, primary, Bannavong, Donna, primary, Jaffe, Kim, primary, Sell, Jendy, primary, Foerter, Kellie Malloy, primary, Canton, David A., primary, Twitty, Christopher G., primary, Osada, Takuya, primary, Lyerly, H. Kim, primary, and Crosby, Erika J., primary

Published
2023
Full Text
View/download PDF

29. Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers

Author

Kaneko, Kensuke, primary, Acharya, Chaitanya R, additional, Nagata, Hiroshi, additional, Yang, Xiao, additional, Hartman, Zachary Conrad, additional, Hobeika, Amy, additional, Hughes, Philip F, additional, Haystead, Timothy A J, additional, Morse, Michael A, additional, Lyerly, Herbert Kim, additional, and Osada, Takuya, additional

Published
2022
Full Text
View/download PDF

30. Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression

Author

Hwang, Bin-Jin, primary, Tsao, Li-Chung, additional, Acharya, Chaitanya R, additional, Trotter, Timothy, additional, Agarwal, Pankaj, additional, Wei, Junping, additional, Wang, Tao, additional, Yang, Xiao-Yi, additional, Lei, Gangjun, additional, Osada, Takuya, additional, Lyerly, Herbert Kim, additional, Morse, Michael A, additional, and Hartman, Zachary Conrad, additional

Published
2022
Full Text
View/download PDF

34. Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity

Author

Abe, Shinya, primary, Nagata, Hiroshi, additional, Crosby, Erika J, additional, Inoue, Yoshiyuki, additional, Kaneko, Kensuke, additional, Liu, Cong-Xiao, additional, Yang, Xiao, additional, Wang, Tao, additional, Acharya, Chaitanya R, additional, Agarwal, Pankaj, additional, Snyder, Joshua, additional, Gwin, William, additional, Morse, Michael A, additional, Zhong, Pei, additional, Lyerly, Herbert Kim, additional, and Osada, Takuya, additional

Published
2022
Full Text
View/download PDF

35. HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study

Author

Osada, Takuya, primary, Crosby, Erika J., additional, Kaneko, Kensuke, additional, Snyder, Joshua C., additional, Ginzel, Joshua D., additional, Acharya, Chaitanya R., additional, Yang, Xiao-Yi, additional, Polascik, Thomas J., additional, Spasojevic, Ivan, additional, Nelson, Rendon C., additional, Hobeika, Amy, additional, Hartman, Zachary C., additional, Neckers, Leonard M., additional, Rogatko, Andre, additional, Hughes, Philip F., additional, Huang, Jiaoti, additional, Morse, Michael A., additional, Haystead, Timothy, additional, and Lyerly, H. Kim, additional

Published
2021
Full Text
View/download PDF

37. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

Author

Acharya, Chaitanya R., Hsu, David S., Anders, Carey K., Anguiano, Ariel, Salter, Kelly H., Walters, Kelli S., Redman, Richard, Moylan, Cynthia A., Mukherjee, Sayan, Barry, William T., Dressman, Holly K., Ginsburg, Geoffrey S., Marcom, Kelly P., Garman, Katherine S., Lyman, Gary H., Nevins, Joseph R., and Potti, Anil

Subjects
Breast cancer -- Care and treatment, Breast cancer -- Risk factors, Breast cancer -- Prognosis, Chemotherapy -- Usage, Gene expression -- Research, Cancer -- Chemotherapy, Cancer -- Usage
Abstract

A study to determine the need for gene expression profiling with clinical and pathological risk factors in the prognosis and therapeutic strategies for early stage breast cancer is conducted. Results confirm that gene expression signatures are useful in refining prognosis for breast cancer.

Published
2008

38. The complete genome sequence of roseobacter denitrificans reveals a mixotrophic rather than photosynthetic metabolism

Author

Swingley, Wesley D., Sadekar, Sumedha, Mastrian, Stephen D., Matthies, Heather J., Hao, Jicheng, Ramos, Hector, Acharya, Chaitanya R., Conrad, Amber L., Taylor, Heather L., Dejesa, Liza C., Shah, Maulik K., O'Huallachain, Maeve E., Lince, Michael T., Blankenship, Robert E., Beatty, J. Thomas, and Touchman, Jeffrey W.

Subjects
Bacteria, Photosynthetic -- Genetic aspects, Bacteria, Photosynthetic -- Research, Bacteria, Photosynthetic -- Physiological aspects, Greenhouse gases -- Research, Genomes -- Research, Biological sciences
Abstract

Purple aerobic anoxygenic phototrophs (AAPs) are the only organisms known to capture light energy to enhance growth only in the presence of oxygen but do not produce oxygen. The highly adaptive AAPs compose more than 10% of the microbial community in some euphotic upper ocean waters and are potentially major contributors to the fixation of the greenhouse gas C[O.sub.2]. We present the complete genomic sequence and feature analysis of the AAP Roseobacter denitrificans, which reveal clues to its physiology. The genome lacks genes that code for known photosynthetic carbon fixation pathways, and most notably missing are genes for the Calvin cycle enzymes ribulose bisphosphate carboxylase (RuBisCO) and phosphoribulokinase. Phyiogenetic evidence implies that this absence could be due to a gene loss from a RuBisCO-containing [alpha]-proteobacterial ancestor. We describe the potential importance of mixotrophic rather than autotrophie C[O.sub.2] fixation pathways in these organisms and suggest that these pathways function to fix C[O.sub.2] for the formation of cellular components but do not permit autotrophic growth. While some genes that code for the redox-dependent regulation of photosynthetic machinery are present, many light sensors and transcriptional regulatory motifs found in purple photosynthetic bacteria are absent.

Published
2007

39. Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Author

Telli, Melinda L., primary, Nagata, Hiroshi, additional, Wapnir, Irene, additional, Acharya, Chaitanya R., additional, Zablotsky, Kaitlin, additional, Fox, Bernard A., additional, Bifulco, Carlo B., additional, Jensen, Shawn M., additional, Ballesteros-Merino, Carmen, additional, Le, Mai Hope, additional, Pierce, Robert H., additional, Browning, Erica, additional, Hermiz, Reneta, additional, Svenson, Lauren, additional, Bannavong, Donna, additional, Jaffe, Kim, additional, Sell, Jendy, additional, Foerter, Kellie Malloy, additional, Canton, David A., additional, Twitty, Christopher G., additional, Osada, Takuya, additional, Lyerly, H. Kim, additional, and Crosby, Erika J., additional

Published
2021
Full Text
View/download PDF

40. Abstract PS17-22: Intratumoral delivery of tavokinogene telseplasmid (plasmid IL-12) and electroporation induces an immune signature that predicts successful combination in patients

Author

Crosby, Erika J, primary, Nagata, Hiroshi, additional, Telli, Melinda L, additional, Acharya, Chaitanya R, additional, Wapnir, Irene, additional, Zablotsky, Kaitlin, additional, Browning, Erica, additional, Hermiz, Reneta, additional, Svenson, Lauren, additional, Bannavong, Donna, additional, Malloy, Kellie, additional, Canton, David A, additional, Twitty, Chris G, additional, Osada, Takuya, additional, and Lyerly, Herbert Kim, additional

Published
2021
Full Text
View/download PDF

41. Retraction: Acharya CR, et al. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008;299(13): 1574-1587.

Author

Acharya, Chaitanya R., Hsu, David S., Anders, Carey K., Anguiano, Ariel, Salter, Kelly H., Walters, Kelli S., Redman, Richard C., Tuchman, Sascha A., Moylan, Cynthia A., Mukherjee, Sayan, Barry, William T., Dressman, Holly K., Ginsburg, Geoffrey S., Marcom, Kelly P., Garman, Katherine S., Lyman, Gary H., Nevins, Joseph R., and Potti, Anil

Published
2012
Full Text
View/download PDF

43. Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

Author

Crosby, Erika J., primary, Acharya, Chaitanya R., additional, Haddad, Anthony-Fayez, additional, Rabiola, Christopher A., additional, Lei, Gangjun, additional, Wei, Jun-Ping, additional, Yang, Xiao-Yi, additional, Wang, Tao, additional, Liu, Cong-Xiao, additional, Wagner, Kay U., additional, Muller, William J., additional, Chodosh, Lewis A., additional, Broadwater, Gloria, additional, Hyslop, Terry, additional, Shepherd, Jonathan H., additional, Hollern, Daniel P., additional, He, Xiaping, additional, Perou, Charles M., additional, Chai, Shengjie, additional, Ashby, Benjamin K., additional, Vincent, Benjamin G., additional, Snyder, Joshua C., additional, Force, Jeremy, additional, Morse, Michael A., additional, Lyerly, Herbert K., additional, and Hartman, Zachary C., additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results