1. CXCL13/CXCR5 signaling axis in cancer.
- Author
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Hussain, Muzammal, Adah, Dickson, Tariq, Muqddas, Lu, Yongzhi, Zhang, Jiancun, and Liu, Jinsong
- Subjects
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CHEMOTACTIC factors , *GROWTH factors , *TUMOR microenvironment , *CYTOLOGY , *CANCER , *CHEMOKINE receptors , *CXCR4 receptors - Abstract
The tumor microenvironment comprises stromal and tumor cells which interact with each other through complex cross-talks that are mediated by a variety of growth factors, cytokines, and chemokines. The chemokine ligand 13 (CXCL13) and its chemokine receptor 5 (CXCR5) are among the key chemotactic factors which play crucial roles in deriving cancer cell biology. CXCL13/CXCR5 signaling axis makes pivotal contributions to the development and progression of several human cancers. In this review, we discuss how CXCL13/CXCR5 signaling modulates cancer cell ability to grow, proliferate, invade, and metastasize. Furthermore, we also discuss the preliminary evidence on context-dependent functioning of this axis within the tumor-immune microenvironment, thus, highlighting its potential dichotomy with respect to anticancer immunity and cancer immune-evasion mechanisms. At the end, we briefly shed light on the therapeutic potential or implications of targeting CXCL13/CXCR5 axis within the tumor microenvironment. Unlabelled Image [ABSTRACT FROM AUTHOR]
- Published
- 2019
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