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18 results on '"Adak, Anindyasundar"'

3. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors

Author

Adak, Anindyasundar, primary, Das, Gaurav, additional, Gupta, Varsha, additional, Khan, Juhee, additional, Mukherjee, Nabanita, additional, Mondal, Prasenjit, additional, Roy, Rajsekhar, additional, Barman, Surajit, additional, Gharai, Prabir Kumar, additional, and Ghosh, Surajit, additional

Published
2022
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9. Extracellular Matrix (ECM)-Mimicking Neuroprotective Injectable Sulfo-Functionalized Peptide Hydrogel for Repairing Brain Injury

Author

Adak, Anindyasundar, Das, Gaurav, Khan, Juhee, Mukherjee, Nabanita, Gupta, Varsha, Mallesh, Rathnam, and Ghosh, Surajit

Abstract

Brain injury can lead to the loss of neuronal functions and connections, along with the damage of the extracellular matrix (ECM). Thus, it ultimately results in devastating long-term damage, and recovery from this damage is a challenging task. To address this issue, we have designed a sulfo-group-functionalized injectable biocompatible peptide hydrogel, which not only mimics the ECM and supports the damaged neurons but also releases a neurotrophic factor around the injured sites of the brain in the presence of the matrix metalloproteinase 9 (MMP9) enzyme. It has also been observed that the driving force of hydrogel formation is a β-sheet secondary structure and π–π stacking interactions between Phe-Phe moieties. The hydrogel is able not only to promote neurite outgrowth of PC12-derived neurons and primary neurons cultured in its presence but also to nullify the toxic effects of anti-nerve growth factor (Anti-NGF)-induced neurons. It also promotes the expression of vital neuronal markers in rat cortical primary neurons, displays substantial potential in neuroregeneration, and also promotes fast recovery of the sham injured mice brain. Increased expression of reactive astrocytes in the hippocampal dentate gyrus region of the sham injured brain clearly suggests its tremendous ability in the neural repair of the damaged brain. Thus, we can convincingly state that our hydrogel is capable of repairing brain injury by mimicking an ECM-like environment and providing neuroprotection to the damaged neurons.

Published
2024
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16. Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection

Author

Biswas, Atanu, primary, Kurkute, Prashant, additional, Saleem, Suraiya, additional, Jana, Batakrishna, additional, Mohapatra, Saswat, additional, Mondal, Prasenjit, additional, Adak, Anindyasundar, additional, Ghosh, Subhajit, additional, Saha, Abhijit, additional, Bhunia, Debmalya, additional, Biswas, Subhash Chandra, additional, and Ghosh, Surajit, additional

Published
2015
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17. A short GC rich DNA derived from microbial origin targets tubulin/microtubules and induces apoptotic death of cancer cells

Author

Jana, Batakrishna, primary, Sarkar, Jayita, additional, Mondal, Prasenjit, additional, Barman, Surajit, additional, Mohapatra, Saswat, additional, Bhunia, Debmalya, additional, Pradhan, Krishnangsu, additional, Saha, Abhijit, additional, Adak, Anindyasundar, additional, Ghosh, Subhajit, additional, and Ghosh, Surajit, additional

Published
2015
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18. Chirality and pH Influence the Self-Assembly of Antimicrobial Lipopeptides with Diverse Nanostructures.

Author

Adak A, Castelletto V, Mendes B, Barrett G, Seitsonen J, and Hamley IW

Subjects
Hydrogen-Ion Concentration, Molecular Structure, Stereoisomerism, Humans, Lipopeptides chemistry, Lipopeptides pharmacology, Nanostructures chemistry, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents chemical synthesis, Microbial Sensitivity Tests, Materials Testing, Biocompatible Materials chemistry, Biocompatible Materials pharmacology, Biocompatible Materials chemical synthesis, Particle Size
Abstract

Chirality plays a crucial role in the self-assembly of biomolecules in nature. Peptides show chirality-dependent conformation and self-assembly. Lipidation of peptides occurs in vivo and has recently been exploited in designed conjugates to drive self-assembly and enhance bioactivity. Here, a library of pH-responsive homochiral and heterochiral lipidated tripeptides has been designed. The designed lipopeptides comprise homochiral C 16 -YKK or C 16 -WKK (where all the amino acids are l-isomers), and two heterochiral conjugates C 16 -Ykk and C 16 -Wkk (where the two lysines are d-isomers). The self-assembly of all the synthesized lipopeptides in aqueous solution was examined using a combination of spectroscopic methods along with cryogenic-transmission electron microscopy (cryo-TEM) and small-angle X-ray scattering (SAXS). Interestingly, it was observed that at acidic pH all the lipopeptides self-assemble into micelles, whereas at basic pH the homochiral lipopeptides self-assemble into nanofibers, whereas the heterochiral lipopeptides self-assemble into nanotapes and nanotubes. A pH switch was demonstrated using a thioflavin T fluorescence probe of β-sheet structure present in the extended structures at pH 8. We demonstrate that both chirality and pH in lipopeptides influence the self-assembly behavior of the model tripeptides, which also show promising bioactivity. Good cytocompatibility is observed in hemolytic assays and antimicrobial activity against both Gram-negative and Gram-positive bacteria is shown through the determination of minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) values and live/dead bacteria staining assay.

Published
2024
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