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Modeling the behavior of a prototype cantilevered X-ray adaptive mirror (held from one end) demonstrates its potential for use on high-performance X-ray beamlines. Similar adaptive mirrors are used on X-ray beamlines to compensate optical aberrations, control wavefronts and tune mirror focal distances at will. Controlled by 1D arrays of piezoceramic actuators, these glancing-incidence mirrors can provide nanometre-scale surface shape adjustment capabilities. However, significant engineering challenges remain for mounting them with low distortion and low environmental sensitivity. Finite-element analysis is used to predict the micron-scale full actuation surface shape from each channel and then linear modeling is applied to investigate the mirrors' ability to reach target profiles. Using either uniform or arbitrary spatial weighting, actuator voltages are optimized using a Moore-Penrose matrix inverse, or pseudoinverse, revealing a spatial dependence on the shape fitting with increasing fidelity farther from the mount.

An all-optical photoinduced lensing method is used to excite and monitor acoustic waves in liquids. Following optical absorption, the laser pulse induces a localized temperature gradient that launches pressure waves in the excited region at the nanosecond time scale. This generates a lens-like optical element in the sample. A probe laser beam senses the refractive index change due to the acoustic and thermal effects. Piezo-optic and thermo-optic coefficients govern how the refractive index of a material changes in response to mechanical stress and temperature variations, respectively. These effects are connected to the physical properties of the liquids and can be accessed by theoretically describing the intensity signal. A complete set of physical properties of ten liquids are quantitatively described in this work. These effects find applications in a wide range of fields, from optical communication, ultrasonic imaging, and sensing to adaptive optics and fundamental research. [ABSTRACT FROM AUTHOR]

The parafoveal area, with its high concentration of photoreceptors and fine retinal capillaries, is crucial for central vision and often exhibits early signs of pathological changes. The current adaptive optics scanning laser ophthalmoscope (AOSLO) provides an excellent tool to acquire accurate and detailed information about the parafoveal area with cellular resolution. However, limited by the scanning speed of two-dimensional scanning, the field of view (FOV) in the AOSLO system was usually less than or equal to 2∘, and the stitching for the parafoveal area required dozens of images, which was time-consuming and laborious. Unfortunately, almost half of patients are unable to obtain stitched images because of their poor fixation. To solve this problem, we integrate AO technology with the line-scan imaging method to build an adaptive optics line scanning ophthalmoscope (AOLSO) system with a larger FOV. In the AOLSO, afocal spherical mirrors in pairs are nonplanar arranged and the distance and angle between optical elements are optimized to minimize the aberrations, two cylinder lenses are orthogonally placed before the imaging sensor to stretch the point spread function (PSF) for sufficiently digitizing light energy. Captured human retinal images show the whole parafoveal area with 5 × 5 ∘ FOV, 60 Hz frame rate and cellular resolutions. Take advantage of the 5∘ FOV of the AOLSO, only 9 frames of the retina are captured with several minutes to stitch a montage image with an FOV of 9 × 9 ∘ , in which photoreceptor counting is performed within approximately 5∘ eccentricity. The AOLSO system not only provides cellular resolution but also has the capability to capture the parafoveal region in a single frame, which offers great potential for noninvasive studying of the parafoveal area. [ABSTRACT FROM AUTHOR]

Direct imaging of exoplanets is particularly challenging due to the high contrast between the planet and the star luminosities, and their small angular separation. In addition to tailored instrumental facilities implementing adaptive optics and coronagraphy, post-processing methods combining several images recorded in pupil tracking mode are needed to attenuate the nuisances corrupting the signals of interest. Most of these post-processing methods build a model of the nuisances from the target observations themselves, resulting in strongly limited detection sensitivity at short angular separations due to the lack of angular diversity. To address this issue, we propose to build the nuisance model from an archive of multiple observations by leveraging supervised deep learning techniques. The proposed approach casts the detection problem as a reconstruction task and captures the structure of the nuisance from two complementary representations of the data. Unlike methods inspired by reference differential imaging, the proposed model is highly non-linear and does not resort to explicit image-to-image similarity measurements and subtractions. The proposed approach also encompasses statistical modelling of learnable spatial features. The latter is beneficial to improve both the detection sensitivity and the robustness against heterogeneous data. We apply the proposed algorithm to several data sets from the VLT/SPHERE instrument, and demonstrate a superior precision-recall trade-off compared to the PACO algorithm. Interestingly, the gain is especially important when the diversity induced by ADI is the most limited, thus supporting the ability of the proposed approach to learn information across multiple observations. [ABSTRACT FROM AUTHOR]

A comprehensive understanding of physio-pathological processes necessitates non-invasive intravital three-dimensional (3D) imaging over varying spatial and temporal scales. However, huge data throughput, optical heterogeneity, surface irregularity, and phototoxicity pose great challenges, leading to an inevitable trade-off between volume size, resolution, speed, sample health, and system complexity. Here, we introduce a compact real-time, ultra-large-scale, high-resolution 3D mesoscope (RUSH3D), achieving uniform resolutions of 2.6 × 2.6 × 6 μm3 across a volume of 8,000 × 6,000 × 400 μm3 at 20 Hz with low phototoxicity. Through the integration of multiple computational imaging techniques, RUSH3D facilitates a 13-fold improvement in data throughput and an orders-of-magnitude reduction in system size and cost. With these advantages, we observed premovement neural activity and cross-day visual representational drift across the mouse cortex, the formation and progression of multiple germinal centers in mouse inguinal lymph nodes, and heterogeneous immune responses following traumatic brain injury—all at single-cell resolution, opening up a horizon for intravital mesoscale study of large-scale intercellular interactions at the organ level. [Display omitted] • RUSH3D allows long-term, fast 3D imaging at centimeter-scale and single-cell resolution • Compact, high-fidelity mesoscale imaging is achieved in native intravital environments • Intercellular interactions across multiple mouse germinal centers are observed in vivo • Cortex-wide multisensory, locomotion neural activities and immune responses are explored in mice RUSH3D, with the integration of multiple computational imaging methods based on a scanning light-field framework, facilitates long-term, high-speed, centimeter-wide mesoscale 3D imaging at single-cell resolution in a compact system for broad practical applications in understanding large-scale intercellular dynamics at the mammalian organ level. We have demonstrated cortex-wide large-population neural recording with cross-day registration during multisensory input, the formation and progression of multiple germinal centers in mouse inguinal lymph nodes, and cortex-wide heterogeneous immune responses after traumatic brain injury. [ABSTRACT FROM AUTHOR]

We identify the progenitor star of SN 2023ixf in Messier 101 using Keck/NIRC2 adaptive optics imaging and pre-explosion Hubble Space Telescope (HST)/Advanced Camera for Surveys (ACS) images. The supernova, localized with diffraction spikes and high-precision astrometry, unambiguously coincides with a progenitor candidate of |$m_\text{F814W}=24.87\pm 0.05$| (AB). Given its reported infrared excess and semiregular variability, we fit a time-dependent spectral energy distribution (SED) model of a dusty red supergiant (RSG) to a combined data set of HST optical, ground-based near-infrared, and Spitzer Infrared Array Camera (IRAC) [3.6], [4.5] photometry. The progenitor resembles an RSG of |$T_\text{eff}=3488\pm 39$| K and |$\log (L/\mathrm{L}_\odot)=5.15\pm 0.02$|⁠ , with a |$0.13\pm 0.01$| dex (⁠|$31.1\pm 1.7$|  per cent) luminosity variation at a period of |$P=1144.7\pm 4.8$| d, obscured by a dusty envelope of |$\tau =2.92\pm 0.02$| at |$1\, \mu \text{m}$| in optical depth (or |$A_\text{V}=8.43\pm 0.11$| mag). The signatures match a post-main-sequence star of |$18.2_{-0.6}^{+1.3}\, \mathrm{M}_\odot$| in zero-age main-sequence mass, among the most massive SN II progenitor, with a pulsation-enhanced mass-loss rate of |$\dot{M}=(4.32\pm 0.26)\times 10^{-4} \, \mathrm{M}_\odot \, \text{yr}^{-1}$|⁠. The dense and confined circumstellar material is ejected during the last episode of radial pulsation before the explosion. Notably, we find strong evidence for variations of |$\tau$| or |$T_\text{eff}$| along with luminosity, a necessary assumption to reproduce the wavelength-dependent variability, which implies periodic dust sublimation and condensation. Given the observed SED, partial dust obscuration remains possible, but any unobstructed binary companion over |$5.6\, \mathrm{ M}_\odot$| can be ruled out. [ABSTRACT FROM AUTHOR]

Adaptive optics ophthalmoscopy has enabled visualization of the in vivo human photoreceptor mosaic in health, disease and its treatment. Despite this, the clinical utility of the imaging technology has been limited by a lack of automated analysis techniques capable of accurately quantifying photoreceptor structure and a lack of an available normative image database. Here, we present a fully automated algorithm for estimating cone spacing and density over a complete adaptive optics montage along with a database of normative images and cone densities. We imaged the cone mosaics surrounding the fovea and along the horizontal and vertical meridians of fifty normal-sighted controls with a custom-built, multimodal adaptive optics scanning light ophthalmoscope. Cone spacing was automatically measured in the frequency domain and spacing measurements were converted to estimates of cone density at all locations across the montage. Consistent with previous reports, cone density measurements were highest near fovea (152,906 ± 53,209 cones/mm2) and decreased exponentially with eccentricity. A 2.5-fold variation was found in cone density estimates at 0.1 mm, this variation decreased to 1.75-fold at 1 mm. We provide all images, mosaic quantifications, and automated software open source. This database will aid investigators in translating adaptive optics ophthalmoscopy to clinical applications. [ABSTRACT FROM AUTHOR]

L-cone opsin expression by gene therapy is a promising treatment for blue cone monochromacy (BCM) caused by congenital lack of long- and middle-wavelength-sensitive (L/M) cone function. Eight patients with BCM and confirmed pathogenic variants at the OPN1LW/OPN1MW gene cluster participated. Optical coherence tomography (OCT), chromatic perimetry, chromatic microperimetry, chromatic visual acuity (VA), and chromaticity thresholds were performed with unmodified commercial equipment and/or methods available in the public domain. Adaptive optics scanning laser ophthalmoscope (AOSLO) imaging was performed in a subset of patients. Outer retinal changes were detectable by OCT with an age-related effect on the foveal disease stage. Rod and short-wavelength-sensitive (S) cone functions were relatively retained by perimetry, although likely impacted by age-related increases in the pre-retinal absorption of short-wavelength lights. The central macula showed a large loss of red sensitivity on dark-adapted microperimetry. Chromatic VAs with high-contrast red gratings on a blue background were not detectable. Color vision was severely deficient. AOSLO imaging showed reduced total cone density with majority of the population being non-waveguiding. This study developed and evaluated specialized outcomes that will be needed for the determination of efficacy and safety in human clinical trials. Dark-adapted microperimetry with a red stimulus sampling the central macula would be a key endpoint to evaluate the light sensitivity improvements. VA changes specific to L-opsin can be measured with red gratings on a bright blue background and should also be considered as outcome measures in future interventional trials. [ABSTRACT FROM AUTHOR]

In wireless optical communication, the optical signal passes through the atmospheric turbulence, resulting in the simultaneous distortion of the amplitude and phase of the optical signal at the receiving end. This article applies the idea of phase contrast method to simultaneously compensate the amplitude and phase of the optical signal at the receiving end, derives the mapping relationship between the compensated phase and light intensity, and obtains the required compensated phase for full-field compensation. Numerical calculations show that when the difference between zero-frequency phase compensation and nonzero-frequency phase compensation is ±π, the maximum light intensity compensation is obtained. Based on the Gerchberg Saxton algorithm, a new method is proposed to invert the compensated phase with the maximum light intensity after full-field compensation and perform full-field correction through the adaptive optical system. The numerical calculation and experiment show that the phase contrast Gerchberg Saxton algorithm can effectively compensate the distorted optical signals under different turbulence, and thus the received signals of optical wireless communication can be corrected in full field. [ABSTRACT FROM AUTHOR]

In this study, we introduce a novel hybrid conjugate gradient method with an adaptive strategy called asHCG method. The asHCG method exhibits the following characteristics. (i) Its search direction guarantees sufficient descent property without dependence on any line search. (ii) It possesses strong convergence for the uniformly convex function using a weak Wolfe line search, and under the same line search, it achieves global convergence for the general function. (iii) Employing the Armijo line search, it provides an approximate guarantee for worst-case complexity for the uniformly convex function. The numerical results demonstrate promising and encouraging performances in both unconstrained optimization problems and image restoration problems. [ABSTRACT FROM AUTHOR]

(200/200) Purpose: Our aim was to evaluate structural alterations of retinal arterioles due to type 1 diabetes (T1D) and/or diabetic retinopathy (DR) under AOSLO imaging. Methods: Each study eye underwent mydriasis and AOSLO imaging in a single-visit study. The instrument's arrangement of four offset aperture images provided two orthogonal split-detector images and enabled isotropic analysis of the arteriolar boundaries. For each arteriole, we calculated the wall-to-lumen ratio (WLR), mean wall thickness, and luminal and external diameters. Results: In total, we enrolled 5 (20.8%) healthy control eyes and 19 eyes of patients with T1D. The DR distribution was: four (16.7%) no-DR, nine (37.5%%) mild or moderate nonproliferative DR (NPDR), and six (25%) severe NPDR or proliferative DR. Mean wall thickness increased significantly in eyes with T1D compared to healthy controls (p = 0.0006) and in eyes with more advanced DR (p = 0.0004). The WLR was significantly higher in eyes with T1D (p = 0.002) or more severe DR (p = 0.004). There was no significant relationship between T1D status or DR severity and any of the arteriolar diameters. Conclusions: In this preliminary study, there appeared to be increases in the WLR and mean wall thickness in eyes with T1D and more severe DR than in the controls and eyes with no/less severe DR. Future studies may further elucidate the relationship between the retinal arteriolar structure and physiologic alterations in DR. [ABSTRACT FROM AUTHOR]

Spaceborne photon-counting LiDAR holds significant potential for shallow-water bathymetry. However, the received photon data often contain substantial noise, complicating the extraction of elevation information. Currently, a denoising algorithm named ordering points to identify the clustering structure (OPTICS) draws people's attention because of its strong performance under high background noise. However, this algorithm's fixed input variables can lead to inaccurate photon distribution parameters in areas near the water bottom, which results in inadequate denoising in these areas, affecting bathymetric accuracy. To address this issue, an Adaptive Variable OPTICS (AV-OPTICS) model is proposed in this paper. Unlike the traditional OPTICS model with fixed input variables, the proposed model dynamically adjusts input variables based on point cloud distribution. This adjustment ensures accurate measurement of photon distribution parameters near the water bottom, thereby enhancing denoising effects in these areas and improving bathymetric accuracy. The findings indicate that, compared to traditional OPTICS methods, AV-OPTICS achieves higher F 1 -values and lower cohesions, demonstrating better denoising performance near the water bottom. Furthermore, this method achieves an average M A E of 0.28 m and R M S E of 0.31 m, indicating better bathymetric accuracy than traditional OPTICS methods. This study provides a promising solution for shallow-water bathymetry based on photon-counting LiDAR data. [ABSTRACT FROM AUTHOR]

Ordered piezoelectric units are designed to achieve unnaturally large strains and artificial vibrational modes, owing to the synergistic effects of multiple units. However, when interfacing with another physical field, the challenge for ordered piezoelectric units is to achieve precise control of individual unit independently while maintaining a large manipulation range. In this study, conformal ordered solid–liquid coupled piezoelectric units are introduced, which effectively reduce stress transfer by as much as 84% between units via incorporating a liquid phase into each unit. This design allows for the generation of considerable strain levels (up to ɛZ = 1.13%) when used with a flexible layer and optimized structure. Hence, these conformal ordered piezoelectric units achieve simultaneous production of large strains and independent electromechanical control for each individual unit. As a practical illustration, a biomimetic piezoelectric adaptive lens and a lens array based on solid–liquid coupled piezoelectric units are designed and fabricated. They offer an extensive zoom range from 100.3 mm to infinity, ultra‐high diopter sensitivity of 70 D mV−1, ultra‐rapid response time of 50 µs, and programmable optical focusing through individual manipulation of each unit. This research paves the way for inspiring new designs for piezoelectric metamaterials and devices for intelligent electromechanical systems. [ABSTRACT FROM AUTHOR]

Integrated photonic chips have significant potential in telecommunications, classic computing, quantum systems, and topological photonics. Direct laser writing offers unique capability for creating three‐dimensional photonic devices in an optical glass chip with quick prototyping. However, it is a challenge for existing laser writing schemes to create index‐modified structures in glass that precisely match the laser focal shape while also achieving high refractive index contrasts and high scanning speeds. Here, we introduce a refractive index modification scheme that combines the advantages of non‐thermal and thermal regime fabrication methods. We also propose a waveguide formation model that is verified through a thorough study on the effects of phase aberrations. The presented new photonic chip fabrication scheme uses a novel focal intensity distribution, where pulse energy is relocated to the bottom of a laser focus by manipulating primary and higher order spherical aberrations. The technique can produce index modifications with high scanning speed (can be 20 mm/s or higher), high index contrast (ranging from 0.009 to 0.021), and high precision to fabricate with arbitrary cross‐sections. This method has potential to expand the capabilities of photonic chips in applications that require small‐scale, high precision, or high contrast refractive index control. [ABSTRACT FROM AUTHOR]

Ground-based thermal infrared observations face substantial challenges in correcting the predominant background emitted as thermal radiation from the atmosphere and the telescope itself. With the upcoming 40 m class ELTs, unprecedented sensitivities from ground will be reached, underlining the need of even more sophisticated background correction strategies. This study aims to investigate the impact of thermal backgrounds on ground-based observations and identify possible limiting factors in dedicated correction strategies. We evaluate temporal and spatial characteristics of the thermal background in direct imaging data obtained with different telescopes and observation modes. In particular, three distinct data sets, acquired using VLT/NACO and KECK/NIRC2, are analyzed. Our analysis reveals that the observations are not fully photon shot noise limited, but exhibit additional sensitivity losses caused by imperfect background compensation in the different data sets. We identify correlations between background fluctuations and the activity of the adaptive optics system. We hypothesize that the pupil modulation of the adaptive optics mirrors introduces high frequency spatial and temporal fluctuations to the background, which could ultimately constrain the detection limit if they are not compensated adequately. [ABSTRACT FROM AUTHOR]

The objective of this study, which is divided into two parts, is twofold: to address long-standing challenges in the sensing of atmospheric turbulence-induced wavefront aberrations under strong scintillation conditions via a comparative analysis of several basic scintillation-resistant wavefront sensing (SR-WFS) architectures and iterative phase retrieval (IPR) techniques (Part I, this paper), and to develop a framework for the potential integration of SR-WFS techniques into practical closed-loop non-astronomical atmospheric adaptive optics (AO) systems (Part II). In this paper, we consider basic SR-WFS mathematical models and phase retrieval algorithms, tradeoffs in sensor design and phase retrieval technique implementation, and methodologies for WFS parameter optimization and performance assessment. The analysis is based on wave-optics numerical simulations imitating realistic turbulence-induced phase aberrations and intensity scintillations, as well as optical field propagation inside the SR-WFSs. Several potential issues important for the practical implementation of SR-WFS and IPR techniques, such as the requirements for phase retrieval computational grid resolution, tolerance with respect to optical element misalignments, and the impact of camera noise and input light non-monochromaticity, are also considered. The results demonstrate that major wavefront sensing requirements desirable for AO operation under strong intensity scintillations can potentially be achieved by transitioning to novel SR-WFS architectures, based on iterative phase retrieval techniques. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the intrasession repeatability of wavefront aberrations obtained by a combined adaptive optics visual simulator and Hartman-Shack aberrometer in pseudophakic eyes with and without previous corneal refractive surgery. Methods: Three consecutive measurements were performed in one eye of each individual. Total ocular aberrations were recorded up to the 5th Zernike order for a 4.5-mm pupil. Repeatability was assessed by calculating the within-subject standard deviation (Sw), the repeatability limit (R), and the intraclass correlation coefficient (ICC). Vector analysis was performed to assess astigmatism variability between scans. Results: The study enrolled 32 normal individuals and 24 individuals with a history of refractive surgery. In normal and eyes that had previous refractive surgery, respectively, the Sw values were 0.155 and 0.176 diopters (D) for sphere and 0.184 and 0.265 D for cylinder. The Sw values for all 3rd order terms ranged from 0.037 to 0.047 µm in normal eyes and 0.044 to 0.063 µm in eyes that had previous refractive surgery. The Sw for primary spherical aberration was 0.020 µm in normal eyes and 0.026 µm in eyes that had previous refractive surgery. ICC values for measurements of astigmatism yielded larger variability (ICC = 0.751 and 0.879). However, both groups demonstrated excellent repeatability (ICC > 0.9) for root mean square higher order aberrations (RMS-HOA) and total RMS values. Conclusions: In pseudophakic eyes, the adaptive optics Hartmann-Shack device demonstrated acceptable repeatability for measurement of sphere and 3rd and 4th order HOAs with higher variability for astigmatism measurements, especially in eyes with a prior history of corneal refractive surgery. [J Refract Surg. 2024;40(9):e645–e653.] [ABSTRACT FROM AUTHOR]

Hybrid optical systems with integrated control mechanisms enable a dynamic adjustment of optical components, ensuring real-time optimization, adaptability to changing conditions, and precise functionality. This control requirement enhances their performance in applications demanding responsiveness, such as autonomous systems, adaptive optics, and advanced imaging technologies. This research introduces a novel approach, employing a dynamic-free Takagi-Sugeno fuzzy sliding mode control (TS-fuzzy SMC) technique, to regulate and stabilize a specific category of chaotic fractional-order modified hybrid optical systems. The method addresses uncertainties and inputsaturation challenges within the system. Leveraging a novel fractional calculus definition along with the non-integer type of the Lyapunov stability theorem and linear matrix inequality principle, the TSfuzzy SMC approach was applied to effectively mitigate and regulate the undesired behavior of the fractional-order chaotic-modified hybrid optical system. Notably, this scheme achieved control without experiencing undesirable chattering phenomena. The paper concludes by offering concrete examples and comparisons, demonstrating how the theoretical findings are applied in real-world scenarios. This provides practical insights into the effectiveness of the proposed approach in diverse applications. [ABSTRACT FROM AUTHOR]

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Abstract Image based cell-specific biomarkers will play an important role in monitoring treatment outcomes of novel therapies in patients with Stargardt (STGD1) disease and may provide information on the exact mechanism of retinal degeneration. This study reports retinal image features from conventional clinical imaging and from corresponding high-resolution imaging with a confocal adaptive optics scanning laser ophthalmoscope (AOSLO) in a heterogenous cohort of patients with Stargardt (STGD1) disease. This is a prospective observational study in which 16 participants with clinically and molecularly confirmed STGD1, and 7 healthy controls underwent clinical assessment and confocal AOSLO imaging. Clinical assessment included short-wavelength and near-infrared fundus autofluorescence, spectral-domain optical coherence tomography, and macular microperimetry. AOSLO images were acquired over a range of retinal eccentricities (0°–20°) and mapped to areas of interest from the clinical images. A regular photoreceptor mosaic was identified in areas of normal or near normal retinal structure on clinical images. Where clinical imaging indicated areas of retinal degeneration, the photoreceptor mosaic was disorganised and lacked unambiguous cones. Discrete hyper-reflective foci were identified in 9 participants with STGD1 within areas of retinal degeneration. A continuous RPE cell mosaic at the fovea was identified in one participant with an optical gap phenotype. The clinical heterogeneity observed in STGD1 is reflected in the findings on confocal AOSLO imaging.

Modeling the behavior of a prototype cantilevered X-ray adaptive mirror (held from one end) demonstrates its potential for use on high-performance X-ray beamlines. Similar adaptive mirrors are used on X-ray beamlines to compensate optical aberrations, control wavefronts and tune mirror focal distances at will. Controlled by 1D arrays of piezoceramic actuators, these glancing-incidence mirrors can provide nanometre-scale surface shape adjustment capabilities. However, significant engineering challenges remain for mounting them with low distortion and low environmental sensitivity. Finite-element analysis is used to predict the micron-scale full actuation surface shape from each channel and then linear modeling is applied to investigate the mirrors' ability to reach target profiles. Using either uniform or arbitrary spatial weighting, actuator voltages are optimized using a Moore–Penrose matrix inverse, or pseudoinverse, revealing a spatial dependence on the shape fitting with increasing fidelity farther from the mount.

Abstract Background Posterior cortical atrophy (PCA) is a rare condition characterized by early-onset and progressive visual impairment. Individuals with PCA have relatively early-onset and progressive dementia, posing certain needs for early detection. Hence, this study aimed to investigate the association of alterations in outer retinal and choroidal structure and microvasculature with PCA neuroimaging and clinical features and the possible effects of apolipoprotein E(APOE) ε4 allele on outer retinal and choroidal alterations in participants with PCA, to detect potential ocular biomarkers for PCA screening. Methods This cross-sectional study included PCA and age- and sex-matched healthy control participants from June 2022 to December 2023. All participants with PCA completed a comprehensive neurological evaluation. All participants were recorded baseline information and underwent an ophthalmic evaluation. Quantitative analyses were performed using swept-source optical coherence tomography (SS-OCT) and angiography (SS-OCTA). Adaptive optics scanning laser ophthalmoscopy (AO-SLO) was performed in some patients. In participants with PCA, the influence of APOE ε4 on outer retinal and choroidal alterations and the correlation of outer retinal and choroidal alterations with PCA neuroimaging and clinical features in participants with PCA were investigated. Results A total of 28 participants (53 eyes) with PCA and 56 healthy control participants (112 eyes) were included in the current study. Compared with healthy control participants, participants with PCA had significantly reduced outer retinal thickness (ORT) (p

Abstract Aim of the present study is to evaluate the relationship between genetic and phenotypic data in a series of patients affected by grade I and II of foveal hypoplasia with stable fixation and good visual acuity using multimodal imaging techniques. All patients underwent complete clinical and instrumental assessment including structural Optical Coherence Tomography (OCT), OCT Angiography and Adaptive Optics (AO) imaging. Central macular thickness (CMT), inner nuclear layer (INL), vessel density in superficial capillary plexus were the main variables evaluated with OCT technology. Cone density, cone spacing, cone regularity, cone dispersion and angular density were the parameters evaluated with AO. Genetic evaluation and trio exome sequencing were performed in all affected individuals. Eight patients (3 males and 5 females) with a mean age of 12.62 years (range 8–18) were enrolled. The mean best corrected visual acuity (BCVA) was 0.18 ± 0.13 logMAR, mean CMT was 291.9 ± 16.6 µm and INL was 26.2 ± 4.6 µm. The absence of a foveal avascular zone (FAZ) was documented by examination of OCT-A in seven patients in the superficial capillary plexus. However, there was a partial FAZ in the deep plexus in patients P5 and P8. Of note, all the patients presented with major retinal vessels clearly crossing the foveal center. All individuals exhibited a grade I or II of foveal hypoplasia. In 5 patients molecular analyses showed an extremely mild form of albinism caused by compound heterozygosity of a TYR pathogenic variant and the hypomorphic p.[Ser192Tyr;Arg402Gln] haplotype. One patient had Waardenburg syndrome type 2A caused by a de novo variant in MITF. Two patients had inconclusive molecular analyses. All the patients displayed abnormalities on OCT-A. Photoreceptor count did not differ from normal subjects according to the current literature, but qualitative analysis of AO imaging showed distinctive features likely related to an abnormal pigment distribution in this subset of individuals. In patients with foveal hypoplasia, genetic and multimodal imaging data, including AO findings, can help understand the physiopathology of the foveal hypoplasia phenotype. This study confirms that cone density and visual function can both be preserved despite the absence of a pit.

Background: Posterior cortical atrophy (PCA) is a rare condition characterized by early-onset and progressive visual impairment. Individuals with PCA have relatively early-onset and progressive dementia, posing certain needs for early detection. Hence, this study aimed to investigate the association of alterations in outer retinal and choroidal structure and microvasculature with PCA neuroimaging and clinical features and the possible effects of apolipoprotein E(APOE) ε4 allele on outer retinal and choroidal alterations in participants with PCA, to detect potential ocular biomarkers for PCA screening. Methods: This cross-sectional study included PCA and age- and sex-matched healthy control participants from June 2022 to December 2023. All participants with PCA completed a comprehensive neurological evaluation. All participants were recorded baseline information and underwent an ophthalmic evaluation. Quantitative analyses were performed using swept-source optical coherence tomography (SS-OCT) and angiography (SS-OCTA). Adaptive optics scanning laser ophthalmoscopy (AO-SLO) was performed in some patients. In participants with PCA, the influence of APOE ε4 on outer retinal and choroidal alterations and the correlation of outer retinal and choroidal alterations with PCA neuroimaging and clinical features in participants with PCA were investigated. Results: A total of 28 participants (53 eyes) with PCA and 56 healthy control participants (112 eyes) were included in the current study. Compared with healthy control participants, participants with PCA had significantly reduced outer retinal thickness (ORT) (p < 0.001), choriocapillaris vessel density (VD) (p = 0.007), choroidal vascular index (CVI) (p = 0.005) and choroidal vascular volume (CVV) (p = 0.003). In participants with PCA, APOE ε4 carriers showed thinner ORT (p = 0.009), and increased choriocapillaris VD (p = 0.004) and CVI (p = 0.004). The PCA neuroimaging features were positively associated with the ORT, CVI and CVV. Furthermore, differential correlations were observed of PCA clinical features with the CRT, CVV and CVI. Conclusions: Our findings highlighted the association of outer retinal and choroidal alterations with PCA neuroimaging and clinical features in participants with PCA. Noninvasive SS-OCT and SS-OCTA can provide potential biomarkers for the diagnosis and management of PCA, improving awareness of PCA syndrome among ophthalmologists, neurologists, and primary care providers. [ABSTRACT FROM AUTHOR]

Background: Disease-causing variants in the KCNV2 gene are associated with "cone dystrophy with supernormal rod responses," a rare autosomal recessive retinal dystrophy. There is no previous report of hypomorphic variants in the disease. Material and Methods: Medical history, genetic testing, ocular examination, high-resolution retinal imaging including adaptive optics scanning light ophthalmoscopy (AOSLO), and functional assessments. Results: A 16-year-old male with mild cone-rod dystrophy presented with reduced central vision and photophobia. Genetic testing showed two variants in KCNV2, c.614_617dupAGCG (p.207AlafsTer166) and c.854T>G (p.Met285Arg), the latter which was previously considered benign. Electrophysiological assessment revealed the pathognomic electroretinogram waveforms associated with KCNV2-retinopathy. Optical coherence tomography showed discrete focal ellipsoid zone disruption, while fundus autofluorescence was normal. Non-waveguiding cones corresponding to areas of loss of photoreceptor integrity were visible on adaptive optics scanning light ophthalmoscopy. Retinal sensitivity and fixation were relatively preserved, with a demonstrable deterioration after 14 months of follow-up. Conclusions: We provide functional and structural evidence that the variant M285R is disease-causing if associated with a loss-of-function variant. To the best of our knowledge, this is the first hypomorphic allele reported in KCNV2. [ABSTRACT FROM AUTHOR]

'Extremely red quasars' (ERQs) are a non-radio-selected, intrinsically luminous population of quasars at cosmic noon selected by their extremely red colour from rest-frame UV to mid-IR. ERQs are uniquely associated with exceptionally broad and blueshifted [O  iii ]  |$\lambda$| 5007 emission reaching speeds |$\gt $| 6000 km s |$^{-1}$|⁠. We obtained adaptive optics integral-field spectroscopic observations using Keck/OSIRIS and Gemini/NIFS of a sample of 10 ERQs with bolometric luminosities (10 |$^{47.0}$| –10 |$^{47.9}$|⁠) erg s |$^{-1}$| at |$z\sim$|  (2.3–3.0). The goal is to measure the sizes and spatially resolved kinematics of the [O  iii ]-emitting regions. We study the surface brightness maps and aperture-extracted spectra and model the point-spread functions. We identify signs of merger activities in the continuum emissions. We identify physically distinct [O  iii ] kinematic components that are bimodal and respectively trace ERQ-driven outflows of velocity dispersion |$\gtrsim$| 250 km s |$^{-1}$| and dynamically quiescent interstellar media. We find that the ERQ-driven ionized outflows are typically at |$\sim$| 1 kpc scales whereas the quiescent ionized gas extend to a few kpc. Compared to normal quasars the extremely fast ERQ-driven [O  iii ] outflows tend to be more compact, supporting the notion that ERQs are in a young stage of quasar/galaxy evolution and represent unique physical conditions beyond orientation differences with normal quasar populations. The kinematically quiescent [O  iii ] emissions in ERQs tend to be spatially resolved but less extended than in normal quasars, which can be explained by global and patchy dust obscuration. The hint of ionization cones suggests some of the obscuration can be partially explained by a patchy torus. [ABSTRACT FROM AUTHOR]

This study investigates the average signal-to-noise ratio $ \left\langle {\textrm{SNR}} \right\rangle $ ⟨ SNR ⟩ at the shot-noise limited receiver of an optical wireless communication system (OWC) that uses collimated Gaussian beam with adaptive optics correction in non-Kolmogorov weak turbulent atmosphere. $ \left\langle {\textrm{SNR}} \right\rangle $ ⟨ SNR ⟩ and the variation in the percentage $ \left\langle {\textrm{SNR}} \right\rangle $ ⟨ SNR ⟩ are calculated and the results are presented against various adaptive optics correction modes, non-Kolmogorov power-law exponent, receiver aperture size, Gaussian beam source size, photodetector quantum efficiency, electronic bandwidth, link length, and turbulence strength. Adaptive optics correction is analyzed for tilt, defocus, astigmatism, coma and trefoil modes and their variations. The effects of adaptive optics compensation are examined that cause an increase in SNR, hence improve the performance of an OWC system using collimated Gaussian beam and operating in the non-Kolmogorov weak turbulent atmosphere. [ABSTRACT FROM AUTHOR]

Impaired retinal blood flow is associated with ocular diseases such as glaucoma, macular degeneration, and diabetic retinopathy. Among several ocular imaging techniques developed to measure retinal blood flow both invasively and non-invasively, adaptive optics (AO)-enabled scanning laser ophthalmoscopy (AO-SLO) resolves individual red blood cells and provides a high resolution with which to measure flow across retinal microvasculature. However, cross-validation of flow measures remains a challenge owing to instrument and patient-specific variability in each imaging technique. Hence, there is a critical need for a well-controlled clinical flow phantom for standardization and to establish blood-flow measures as clinical biomarkers for early diagnosis. Here, we present the design and validation of a simple, compact, portable, linear flow phantom based on a direct current motor and a conveyor-belt system that provides linear velocity tuning within the retinal microvasculature range (0.5–7 mm/s). The model was evaluated using a sensitive AO-SLO line-scan technique, which showed a <6% standard deviation from the true velocity. Further, a clinical SLO instrument showed a linear correlation with the phantom's true velocity (r2 > 0.997). This model has great potential to calibrate, evaluate, and improve the accuracy of existing clinical imaging systems for retinal blood flow and aid in the diagnosis of ocular diseases with abnormal blood flow. [ABSTRACT FROM AUTHOR]

Context. The recent IRLOS upgrade for VLT/MUSE narrow field mode (NFM) introduced a full-pupil mode to enhance sensitivity and sky coverage. This involved replacing the 2 × 2 Shack-Hartmann sensor with a single lens for full-aperture photon collection, which also enabled the engagement of the linearized focal-plane technique (LIFT) wavefront sensor instead. However, initial on-sky LIFT experiments have highlighted a complex point spread function (PSF) structure due to strong and polychromatic non-common path aberrations (NCPAs), complicating the accurate retrieval of tip-tilt and focus using LIFT. Aims. This study aims to conduct the first on-sky validation of LIFT on VLT/UT4, outline challenges encountered during the tests, and propose solutions for increasing the robustness of LIFT in on-sky operations. Methods. We developed a two-stage approach to focal-plane wavefront sensing, where tip-tilt and focus retrieval done with LIFT is preceded by the NCPA calibration step. The resulting NCPA estimate is subsequently used by LIFT. To perform the calibration, we proposed a method capable of retrieving the information about NCPAs directly from on-sky focal-plane PSFs. Results. We verified the efficacy of this approach in simulated and on-sky tests. Our results demonstrate that adopting the two-stage approach has led to a significant improvement in the accuracy of the defocus estimation performed by LIFT, even under challenging low-flux conditions. Conclusions. The efficacy of LIFT as a slow and truth focus sensor in practical scenarios has been demonstrated. However, integrating NCPA calibration with LIFT is essential to verifying its practical application in the real system. Additionally, the proposed calibration step can serve as an independent and minimally invasive approach to evaluate NCPA on-sky. [ABSTRACT FROM AUTHOR]

Context. Multiconjugate adaptive optics (MCAO) can overcome atmospheric anisoplanatism to achieve high-resolution imaging with a large field of view (FOV). Atmospheric tomography is the key technology for MCAO. The commonly used modal tomography approach reconstructs the three-dimensional atmospheric turbulence wavefront aberration based on the wavefront sensor (WFS) detection information from multiple guide star (GS) directions. However, the atmospheric tomography problem is severely ill-posed. The incomplete GS coverage in the FOV coupled with the WFS detection error significantly affects the reconstruction accuracy of the three-dimensional atmospheric turbulence wavefront aberration, leading to a nonuniform aberration detection precision over the whole FOV. Aims. We propose an efficient approach for achieving accurate atmospheric tomography to overcome the limitations of the traditional modal tomography approach. Methods. We employed a deep-learning-based approach to the tomographic reconstruction of the three-dimensional atmospheric turbulence wavefront aberration. We propose an atmospheric tomography residual network (AT-ResNet) that is specifically designed for this task, which can directly generate wavefronts of multiple turbulence layers based on the Shack-Hartmann (SH) WFS detection images from multiple GS directions. The AT-ResNet was trained under different turbulence intensity conditions to improve its generalization ability. We verified the performance of the proposed approach under different conditions and compared it with the traditional modal tomography approach. Results. The well-trained AT-ResNet demonstrates a superior performance compared to the traditional modal tomography approach under different atmospheric turbulence intensities, various turbulence layer distributions, higher-order turbulence aberrations, detection noise, and reduced GSs conditions. The proposed approach effectively addresses the limitations of the modal tomography approach, leading to a notable improvement in the accuracy of atmospheric tomography. It achieves a highly uniform and high-precision wavefront reconstruction over the whole FOV. This study holds great significance for the development and application of the MCAO technology. [ABSTRACT FROM AUTHOR]

Context. Cold planets, including all habitable planets, produce only scattered light emission in the visual to near-infrared wavelength range. For this reason it is highly desirable to adapt the technique for the direct imaging of reflected light from extra-solar planets. Aims. For the nearby system ε Eri, we want to set much deeper detection limits for the expected scattered radiation from the radial velocity planet candidate (≈0.7 MJ) and the warm dust using the VLT/SPHERE adaptive optics (AO) instrument with the ZIMPOL imaging polarimeter. Methods. We carried out very deep imaging polarimetry of ε Eri based on 38.5 h of integration time with a broad-band filter (λc = 735 nm) for the search of the polarization signal from a planet or from circumstellar dust using AO, coronagraphy, high precision differential polarimetry, and angular differential imaging. The data were collected during 12 nights within four epochs distributed over 14 months and we searched for a signal in the individual epochs. We also combined the full data set to achieve an even higher contrast limit considering the Keplerian motion using the K-Stacker software. All data were also combined for the search of the scattering signal from extended dust clouds. We improved various data reduction and post-processing procedures and also developed new ones to enhance the sensitivity of SPHERE/ZIMPOL further. The final detection limits were quantified and we investigated the potential of SPHERE/ZIMPOL for deeper observations. Results. The data of ε Eridani provide unprecedented contrast limits but no significant detection of a point source or an extended signal from circumstellar dust. For each observing epoch, we achieved a 5 σ풩 point source contrast for the polarized intensity CP = Qϕ/I★ between 2 × 10−8 and 4 × 10−8 at a separation of ρ ≈ 1″, which is as expected for the proposed radial velocity planet at a quadrature phase. The polarimetric contrast limits are close to the photon noise limits for ρ > 0.6″ or about six times to 50 times better than the intensity limits because polarimetric imaging is much more efficient for speckle suppression. Combining the data for the search of a planet moving on a Keplerian orbit with the K-Stacker technique improves the contrast limits further by about a factor of two, when compared to an epoch, to about CP = 0.8 × 10−8 at ρ = 1″. This would allow the detection of a planet with a radius of about 2.5 RJ. Should future astrometry provide strong constraints on the position of the planet, then a 3 σ풩 detection at 1″ with CP ≈ 5 × 10−9 would be within reach of our data. The surface brightness contrast limits achieved for the polarized intensity from an extended scattering region is about 15 mag arcsec−2 at 1″ or up to 3 mag arcsec−2 deeper than previous limits. For ε Eri, these limits exclude the presence of a narrow dust ring and they constrain the dust properties. The photon statistics would allow deeper limits but we find a very weak systematic noise pattern probably introduced by polarimetric calibration errors. Conclusions. This ε Eri study shows that the polarimetric contrast limits for reflecting planets with SPHERE/ZIMPOL can be improved to a level below Cp < 10−8 by just collecting more data during many nights using software such as K-Stacker, which can combine all data considering the expected planet orbit. Contrast limits of Cp ≈ 10−9 are within reach for ε Eri if the search can be optimized for a planet with a well-known orbit. This limit is also attainable for other bright nearby stars, such as α Cen or Sirius A. Such data also provide unprecedented sensitivity for the search of extended polarized emission from warm circumstellar dust. [ABSTRACT FROM AUTHOR]

Context. The GRAVITY+ upgrade implies a complete renewal of its adaptive optics (AO) systems. Its complex design, featuring moving components between the deformable mirrors and the wavefront sensors, requires the monitoring and auto-calibrating of the lateral mis-registrations of the system while in operation. Aims. For preset and target acquisition, large lateral registration errors must be assessed in open loop to bring the system to a state where the AO loop closes. In closed loop, these errors must be monitored and corrected, without impacting the science. Methods. With respect to the first requirement, our method is perturbative, with two-dimensional modes intentionally applied to the system and correlated to a reference interaction matrix. For the second requirement, we applied a non-perturbative approach that searches for specific patterns in temporal correlations in the closed loop telemetry. This signal is produced by the noise propagation through the AO loop. Results. Our methods were validated through simulations and on the GRAVITY+ development bench. The first method robustly estimates the lateral mis-registrations, in a single fit and with a sub-subaperture resolution while in an open loop. The second method is not absolute, but it does successfully bring the system towards a negligible mis-registration error, with a limited turbulence bias. Both methods proved to robustly work on a system still under development and not fully characterised. Conclusions. Tested with Shack-Hartmann wavefront sensors, the proposed methods are versatile and easily adaptable to other AO instruments, such as the pyramid, which stands as a baseline for all future AO systems. The non-perturbative method, not relying on an interaction matrix model and being sparse in the Fourier domain, is particularly suitable to the next generation of AO systems for extremely large telescopes that will present an unprecedented level of complexity and numbers of actuators. [ABSTRACT FROM AUTHOR]

Context. η Tel is an 18 Myr system composed of a 2.09 M⊙ A-type star with an M7-M8 brown dwarf companion, η Tel B. The two objects have a projected separation of 4″.2 (~208 au). This system has been targeted by high-contrast imaging campaigns for over 20 yr, facilitating its orbital and photometric characterization. The companion, η Tel B, both bright and on a wide orbit, is an ideal candidate for a detailed examination of its position and the characterization of its atmosphere. Aims. To explore the orbital parameters of η Tel B, measure its contrast, and investigate its close surroundings, we analyzed three new SPHERE/IRDIS coronagraphic observations. Our objectives are to investigate the possibility of a circumplanetary disk or a close companion around η Tel B, and characterize its orbit by combining this new data set with archival data acquired in the past two decades. Methods. The IRDIS data are reduced with state-of-the-art algorithms to achieve a contrast with respect to the star of 1.0 × 10−5 at the location of the companion. Using the NEGative Fake Companion technique (NEGFC), we measure the astrometric positions and flux of η Tel B for the three IRDIS epochs. Together with the measurements presented in the literature, the baseline of the astrometric follow-up is 19 yr. Results. We calculate a contrast for the companion of 6.8 magnitudes in the H band. The separation and position angle measured are 4″.218 and 167.3 degrees, respectively. The astrometric positions of the companions are calculated with an uncertainty of 4 milliarc-seconds (mas) in separation and 0.2 degrees in position angle. These are the smallest astrometrical uncertainties of η Tel B obtained so far. The orbital parameters are estimated using the Orvara code, including all available epochs. The orbital analysis is performed taking into account the Gaia-HIPPARCOS acceleration of the system. Suppressing its point spread function (PSF), we have produced contrast curves centered on the brown dwarf in order to constrain our detection capabilities for a disk or companions around it. Conclusions. After considering only orbits that could not disrupt the outer debris disk around η Tel A, our orbital analysis reveals a low eccentric orbit (e ~ 0.34) with an inclination of 81.9 degrees (nearly edge-on) and a semi-major axis of 218 au. Furthermore, we determine the mass of η Tel B to be 48 MJup, consistent with previous calculations from the literature based on evolutionary models. Finally, we do not detect any significant residual pointing to the presence of a satellite or a disk around the brown dwarf. The retrieved detection limits allow us to discard massive objects around η Tel B with masses down to 1.6 MJup at a separation of 33 au. [ABSTRACT FROM AUTHOR]

Context. The pyramid wavefront sensor (PyWFS) provides the required sensitivity for demanding future adaptive optics (AO) instruments. However, the PyWFS is highly nonlinear and requires the use of beam modulation to successfully close an AO loop under varying atmospheric turbulence conditions. This comes at the expense of a loss in sensitivity. Aims. We trained, analyzed, and compared the use of deep neural networks (NNs) as nonlinear estimators for the nonmodulated PyWFS, identifying the most suitable NN architecture for a reliable closed-loop AO. Methods. We developed a novel training strategy for NNs that seeks to accommodate for changes in residual statistics between open and closed loops, plus the addition of noise for robustness purposes. Through simulations, we tested and compared several deep NNs from classical to new convolutional neural networks (CNNs), plus the most recent transformer neural network (TNN; global context visual transformer, GCViT), first for an open loop and then for a closed loop. By identifying and properly retraining the most adequate deep neural net, we tested its simulated performance first in an open loop and then for closing an AO loop at a variety of noise and turbulence conditions. We finally tested the trained NN ability to close a real AO loop for an optical bench. Results. Using open-loop simulated data, we observe that a TNN (GCViT) largely surpasses any CNN in estimation accuracy in a wide range of turbulence conditions. Moreover, the TNN performs better in a simulated closed loop than CNNs, avoiding estimation issues at the pupil borders. When closing the loop at strong turbulence and low noise, the TNN using nonmodulated PyWFS data is able to close the loop, similar to a PyWFS with 12λ/D of modulation. When the noise is increased, only the TNN is able to close the loop, while the standard linear reconstructor fails even when a modulation is introduced. Using the GCViT, we closed a real AO loop in the optical bench and achieved a Strehl ratio between 0.28 and 0.77 for turbulence conditions corresponding to Fried parameters ranging from 6 to 20 cm, respectively. Conclusions. Through a variety of simulated and experimental results, we demonstrate that a TNN is the most suitable architecture for extending the dynamic range without sacrificing sensitivity for a nonmodulated PyWFS. It opens the path for using nonmodulated Pyramid WFSs in an unprecedented range of atmospheric and noise conditions. [ABSTRACT FROM AUTHOR]

Context. Ground-based large-aperture telescopes, interferometers, and future extremely large telescopes equipped with adaptive optics (AO) systems provide angular resolution and high-contrast performance superior to space-based telescopes at thermal infrared wavelengths. Their sensitivity, however, is critically limited by the high thermal background inherent to ground-based observations in this wavelength regime. Aims. We aim to improve the subtraction quality of the thermal infrared background from ground-based observations using principal component analysis (PCA). Methods. We used data obtained with the Nulling-Optimized Mid-Infrared Camera on the Large Binocular Telescope Interferometer as a proxy for general high-sensitivity AO-assisted ground-based data. We applied both a classical background subtraction – using the mean of dedicated background observations – and a new background subtraction based on a PCA of the background observations. We compared the performances of these two methods in both high-contrast imaging and aperture photometry. Results. Compared to the classical approach for background subtraction, PCA background subtraction delivers up to two times better contrasts down to the diffraction limit of the LBT's primary aperture (i.e., 350 mas in N-band), that is, in the case of high-contrast imaging. An improvement factor between two and three was obtained over the mean background retrieval within the diffraction limit in the case of aperture photometry. Conclusions. The PCA background subtraction significantly improves the sensitivity of ground-based thermal infrared imaging observations. When apply to LBTI's nulling interferometry data, we expect the method to improve the sensitivity by a similar factor of two to three. This study paves the way to maximizing the potential of future infrared ground-based instruments and facilities, such as the future 30m-class telescopes. [ABSTRACT FROM AUTHOR]

Stargardt disease (STGD1), associated with biallelic variants in the ABCA4 gene, is the most common heritable macular dystrophy and is currently untreatable. To identify potential treatment targets, we characterized surviving STGD1 photoreceptors. We used clinical data to identify macular regions with surviving STGD1 photoreceptors. We compared the hyperreflective bands in the optical coherence tomographic (OCT) images that correspond to structures in the STGD1 photoreceptor inner segments to those in controls. We used adaptive optics scanning light ophthalmoscopy (AO-SLO) to study the distribution of cones and AO-OCT to evaluate the interface of photoreceptors and retinal pigment epithelium (RPE). We found that the profile of the hyperreflective bands differed dramatically between patients with STGD1 and controls. AO-SLOs showed patches in which cone densities were similar to those in healthy retinas and others in which the cone population was sparse. In regions replete with cones, there was no debris at the photoreceptor-RPE interface. In regions with sparse cones, there was abundant debris. Our results raise the possibility that pharmaceutical means may protect surviving photoreceptors and so mitigate vision loss in patients with STGD1. [ABSTRACT FROM AUTHOR]

Photoreceptors (PRs) and retinal pigment epithelial (RPE) cells form a functional unit called the PR-RPE complex. The PR-RPE complex plays a critical role in maintaining retinal homeostasis and function, and the quantification of its structure and topographical arrangement across the macula are important for understanding the etiology, mechanisms, and progression of many retinal diseases. However, the three-dimensional cellular morphology of the PR-RPE complex in living human eyes has not been completely described due to limitations in imaging techniques. We used the cellular resolution and depth-sectioning capabilities of a custom, high-speed Fourier domain mode-locked laser-based adaptive optics–optical coherence tomography (FDML-AO-OCT) platform to characterize human PR-RPE complex topography across the temporal macula from eleven healthy volunteers. With the aid of a deep learning algorithm, key metrics were extracted from the PR-RPE complex of averaged AO-OCT volumes including PR and RPE cell density, PR outer segment length (OSL), and PR/RPE ratio. We found a tight grouping among our cohort for PR density, with a mean (±SD) value of 53,329 (±8106) cells/mm2 at 1° decreasing to 8669 (±737) cells/mm2 at 12°. We observed a power function relationship between eccentricity and both PR density and PR/RPE ratio. We found similar variability in our RPE density measures, with a mean value of 7335 (±681) cells/mm2 at 1° decreasing to 5547 (±356) cells/mm2 at 12°, exhibiting a linear relationship with a negative slope of −123 cells/mm2 per degree. OSL monotonically decreased from 33.3 (±2.4) µm at 1° to 18.0 (±1.8) µm at 12°, following a second-order polynomial relationship. PR/RPE ratio decreased from 7.3 (±0.9) µm at 1° to 1.5 (±0.1) µm at 12°. The normative data from this investigation will help lay a foundation for future studies of retinal pathology. [ABSTRACT FROM AUTHOR]

Background: Macular telangiectasia (MacTel), also known as idiopathic juxtafoveolar telangiectasis (IJFTs), involves telangiectatic changes in the macular capillary network. The most common variant, MacTel type 2, has distinct clinical features and management strategies. Methods: This study offers a comprehensive review of MacTel and focuses on a series of three patients diagnosed with MacTel type 2 in our clinic. A meticulous ophthalmological evaluation, augmented by high-resolution imaging techniques like optical coherence tomography (OCT), OCT angiography (OCT-A), fundus autofluorescence (FAF), fluorescein angiography (FA), and adaptive optics (AOs) imaging, was conducted. Results: The findings revealed normal anterior segment features and a grayish discoloration in the temporal perifoveal area on fundus examination. OCT exhibited hyporeflective cavities in the inner and outer neurosensory retina, along with other changes, while OCT-A identified retinal telangiectatic vessels in the deep capillary plexus. FAF demonstrated increased foveal autofluorescence, while FA initially detected telangiectatic capillaries followed by diffuse perilesional leakage in the later phase. Adaptive optics images showed the cone mosaic pattern. Notably, one patient developed a macular hole as a complication, which was successfully managed surgically. Conclusion: This study underscores the challenges in diagnosing and managing MacTel, emphasizing the importance of a multidisciplinary approach and regular follow-ups for optimal outcomes. [ABSTRACT FROM AUTHOR]

A major hurdle to therapeutic development in cerebral small vessel diseases is the lack of in-vivo method that can be used repeatedly for evaluating directly cerebral microvessels. We hypothesised that Adaptive Optics (AO), which allows resolution images up to 1–2 μm/pixel at retinal level, could provide a biomarker for monitoring vascular changes in CADASIL, a genetic form of such condition. In 98 patients and 35 healthy individuals, the wall to lumen ratio (WLR), outer and inner diameter, wall thickness and wall cross-sectional area were measured in a parapapillary and/or paramacular retinal artery. The ratio of vessel diameters before and after light flicker stimulations was also calculated to measure vasoreactivity (VR). Multivariate mixed-model analysis showed that WLR was increased and associated with a larger wall thickness and smaller internal diameter of retinal arteries in patients. The difference was maximal at the youngest age and gradually reduced with aging. Average VR in patients was less than half of that of controls since the youngest age. Any robust association was found with clinical or imaging manifestations of the disease. Thus, AO enables the detection of early functional or structural vascular alterations in CADASIL but with no obvious link to the clinical or imaging severity. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to investigate the outer retinal changes in a patient with type 2 acute macular neuroretinopathy (AMN). Methods: A 35-year-old White woman complaining of a unilateral blind spot was imaged using various retinal imaging modalities including clinical optical coherence tomography (OCT), OCT-angiography, fundus fluorescein angiography, and adaptive optics (AO). Results: Fundus examination revealed multiple paracentral reddish brown petaloid lesions in the symptomatic left eye, while the other eye was unremarkable. Clinical OCT showed areas of hyperreflectance at the outer plexiform layer/outer nuclear layer complex with a disrupted inner/outer segment junction, which are characteristic features of type 2 AMN. AO imaging further revealed either shortening or absence of cone outer segments within the AMN lesions attributing to the darker features observed in the en face images from fundus photography and scanning laser ophthalmoscopy. Conclusion: The AO findings indicate that the petaloid lesions in type 2 AMN are caused by a combination of the shortening and absence of the outer segment in individual cone photoreceptors. [ABSTRACT FROM AUTHOR]

Background: Elevated intracranial pressure (ICP) is a serious and potentially lifethreatening condition, for which clinically useful non-invasive measures have been elusive, in some cases due to their inadequate sensitivity and specificity. Our aim was to evaluate novel non-invasive ophthalmic imaging of selected pathological features seen in elevated ICP, namely peripapillary hyperreflective ovoid mass-like structures (PHOMS), peripapillary wrinkles (PPW) and retinal folds (RF) as potential biomarkers of elevated ICP. Methods: This single-center pilot study included subjects with untreated or incompletely treated high ICP. The retinas of these subjects were evaluated with averaged en-face optical coherence tomography (OCT), OCT retinal cross-sections (OCT B-scans), adaptive optics scanning light ophthalmoscopy (AOSLO), and fundus photos. Results: Seven subjects were included in the study. 6 subjects with high ICP (5 idiopathic intracranial hypertension, 1 medication induced, 30.8 ± 8.6 years, 75% female, 5 with papilledema) and 1 control (20-25 years) were included. PHOMS, PPW and RF were present in all subjects with papilledema, but neither in the high ICP subject without papilledema nor in the control subject. Averaged enface OCT scans and AOSLO were more sensitive for PPW and RF than OCT B-scans and commercial fundus photos. Conclusion: PPW, RF and PHOMS volume have potential as non-invasive biomarkers of ICP. Novel imaging modalities may improve sensitivity. However, lack of automated image acquisition and processing limits current widespread adoption in clinical settings. Further research is needed to validate these structures as biomarkers for elevated ICP and improve clinical utility. [ABSTRACT FROM AUTHOR]

Free space optical technology promises to revolutionize point-to-point communications systems. By taking advantage of their vastly higher frequencies, coherent optical systems outperform their radio counterparts by orders of magnitude in achievable data throughput, while simultaneously lowering the required size, weight, and power (SWaP), making them ideal for mobile applications. However, the widespread implementation of this technology has been largely hindered by the effects of atmospheric turbulence, often necessitating complex higher-order adaptive optics systems that are largely unsuitable for deployment on mobile platforms. By employing tip/tilt beam-stabilization, we present the results of a bespoke low-SWaP optical terminal that demonstrated single-mode fiber (SMF) coupling. This was achieved by autonomously acquiring and tracking the targets using a combination of aircraft transponder and machine vision feedback to a root-mean-square (RMS) tracking error of 29.4 µrad and at angular rates of up to 0.83 deg/s. To the authors' knowledge, these works constitute the first published SMF coupled optical link to a full-sized helicopter, and we describe derived quantities relevant to the future refinement of such links. The ability to achieve SMF coupling without the constraints of complex adaptive optics systems positions this technology as a versatile quantum-capable communications solution for land-, air-, and sea-based platforms ranging across commercial, scientific, and military operators. [ABSTRACT FROM AUTHOR]

Due to its complex spatial distribution, the higher-order Hermite–Gaussian mode possesses significant application in fields such as precision measurement and optical communication. The spatial light modulator, with its capability to modulate the complex amplitude distribution of the incident light field, finds extensive applications in optical information processing and adaptive optics, thus making it an indispensable tool in these fields. Using cascaded spatial light modulators can efficiently and superbly generate a higher-order Hermite–Gaussian mode; however, the experimental system is challenging, and there are many influencing factors, such as the misalignment between the optical field on the plane of the second spatial light modulator and the hologram loaded onto it, as well as the spot size of the optical field on the plane of the second spatial light modulator. In this paper, we analyzed the influence of the above factors on the quality of generating a higher-order Hermite–Gaussian mode, providing a reference for the efficient and high-quality generation of the higher-order Hermite–Gaussian mode. [ABSTRACT FROM AUTHOR]

High-resolution cross-correlation spectroscopy (HRCCS) combined with adaptive optics has been enormously successful in advancing our knowledge of exoplanet atmospheres, from chemistry to rotation and atmospheric dynamics. This powerful technique now drives major science cases for ELT instrumentation including METIS/ELT, GMTNIRS/GMT, and MICHI/TMT, targeting biosignatures on rocky planets at 3–5 μ m, but remains untested beyond 3.5 μ m where the sky thermal background begins to provide the dominant contribution to the noise. We present 3.51–5.21 μ m M -band CRIRES+/VLT observations of the archetypal young directly imaged gas giant β Pictoris b, detecting CO absorption at S/N = 6.6 at 4.73 μ m and H2O at S/N = 5.7, and thus extending the use of HRCCS into the thermal background noise dominated infrared. Using this novel spectral range to search for more diverse chemistry, we report marginal evidence of SiO at S/N = 4.3, potentially indicative that previously proposed magnesium–silicate clouds in the atmosphere are either patchy, transparent at M -band wavelengths, or possibly absent on the planetary hemisphere observed. The molecular detections are rotationally broadened by the spin of β Pic b, and we infer a planetary rotation velocity of v sin(i) = 22 ± 2 km s−1 from the cross-correlation with the H2O model template, consistent with previous K -band studies. We discuss the observational challenges posed by the thermal background and telluric contamination in the M -band, the custom analysis procedures required to mitigate these issues, and the opportunities to exploit this new infrared window for HRCCS using existing and next-generation instrumentation. [ABSTRACT FROM AUTHOR]

Since volcanic activity was first discovered on Io from Voyager images in 1979, changes on Io's surface have been monitored from both spacecraft and ground‐based telescopes. Here, we present the highest spatial resolution images of Io ever obtained from a ground‐based telescope. These images, acquired by the SHARK‐VIS instrument on the Large Binocular Telescope, show evidence of a major resurfacing event on Io's trailing hemisphere. When compared to the most recent spacecraft images, the SHARK‐VIS images show that a plume deposit from a powerful eruption at Pillan Patera has covered part of the long‐lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth‐based telescopes. The SHARK‐VIS instrument ushers in a new era of high resolution imaging of Io's surface using adaptive optics at visible wavelengths. Plain Language Summary: A new instrument, called SHARK‐VIS, on the Large Binocular Telescope in Arizona, has obtained high spatial resolution, visible wavelength images of Io, the highly volcanic moon of Jupiter. Large multicolored plume deposits were imaged, revealing where the red deposit from a volcano named Pele was covered by another plume deposit from another volcano, named Pillan Patera, the site of a powerful eruption in 2021. SHARK‐VIS ushers in a new age in planetary imaging. Key Points: High resolution images taken with SHARK‐VIS at LBT reveal low and high albedo features obscuring a portion of Pele's red ring on IoThis new eruption deposit likely originated from a powerful eruption in August 2021 located at Pillan PateraSuch images provide a new imaging capability that yields vital context to other observations of planetary surfaces [ABSTRACT FROM AUTHOR]

Atmospheric turbulence characteristics are essential in determining the quality of astronomical images and implementing adaptive optics systems. In this study, the vertical distributions of optical turbulence at the Peak Terskol observatory (43.27472°N 42.50083°E, 3127 m a.s.l.) using the Era-5 reanalysis and scintillation measurements are investigated. For the closest reanalysis grid node to the observatory, vertical profiles of the structural constant of the air refractive index turbulent fluctuations C n 2 were obtained. The calculated C n 2 (z) vertical profiles are compared with the vertical distribution of turbulence intensity obtained from tomographic measurements with a Shack–Hartmann sensor. The atmospheric coherence length at the location of Terskol Peak was estimated. Using a combination of atmospheric models and paramaterization schemes of turbulence, C n 2 (z) profiles at Mt. Kurapdag were obtained. The values of atmospheric coherence length at Peak Terskol are compared with estimated values of this length at the ten astronomical sites, including Ali, Lenghu and Daocheng. [ABSTRACT FROM AUTHOR]

We present the deepest J −Ks near-infrared photometry of the globular cluster M5 (NGC 5904) from observations taken with the Gemini South Adaptive Optics Imager in tandem with the Gemini Multi-conjugate adaptive optics System (GeMS) on the 8.1-m Gemini South telescope. Point spread function (PSF) photometry was carried out using a spatially variable PSF, zero-point calibrations based on correlations to a standard photometric catalogue, colour corrections, and crowding corrections. The latter corrections provided a new challenge given the field variations of the adaptive optics corrections in the central crowded regions of this cluster. The final photometric precision in our J− Ks colour–magnitude diagram exposes a dispersion among the lower main-sequence stars of M5 for the first time. This dispersion occurs below a main-sequence knee due to variations in the helium and CNO (carbon, nitrogen, and oxygen) abundances from multiple stellar populations, consistent with results from the bright evolved stars in this cluster from ultraviolet to near-infrared Hubble Space Telescope photometry and ground-based spectroscopy. This paper completes our original GeMS quality analysis programme, providing insights into adaptive optics analyses in crowded fields. [ABSTRACT FROM AUTHOR]

Strong gravitational lensing is a powerful probe of the distribution of matter on sub-kpc scales. It can be used to test the existence of completely dark sub-haloes surrounding galaxies, as predicted by the standard cold dark matter model, or to test alternative dark matter models. The constraining power of the method depends strongly on photometric and astrometric precision and accuracy. We simulate and quantify the capabilities of upcoming adaptive optics systems and advanced instruments on ground-based telescopes, focusing as an illustration on the Keck Telescope (OSIRIS + KAPA, LIGER + KAPA) and the Thirty Meter Telescope (TMT; IRIS + NFIRAOS). We show that these new systems will achieve dramatic improvements over current ones in both photometric and astrometric precision. Narrow line flux ratio errors below 2 per cent, and submilliarcsecond astrometric precision will be attainable for typical quadruply imaged quasars. With TMT, the exposure times required will be of order a few minutes per system, enabling the follow-up of 100–1000 systems expected to be discovered by the Rubin, Euclid, and Roman Telescopes. [ABSTRACT FROM AUTHOR]

This study tested if a high-resolution, multi-modal, multi-scale retinal imaging instrument can provide novel information about structural abnormalities in vivo. The study examined 11 patients with very mild to moderate non-proliferative diabetic retinopathy (NPDR) and 10 healthy subjects using fundus photography, optical coherence tomography (OCT), OCT angiography (OCTA), adaptive optics scanning laser ophthalmoscopy (AO-SLO), adaptive optics OCT and OCTA (AO-OCT(A)). Of 21 eyes of 11 patients, 11 had very mild NPDR, 8 had mild NPDR, 2 had moderate NPDR, and 1 had no retinopathy. Using AO-SLO, capillary looping, inflections and dilations were detected in 8 patients with very mild or mild NPDR, and microaneurysms containing hyperreflective granular elements were visible in 9 patients with mild or moderate NPDR. Most of the abnormalities were seen to be perfused in the corresponding OCTA scans while a few capillary loops appeared to be occluded or perfused at a non-detectable flow rate, possibly because of hypoperfusion. In one patient with moderate NPDR, non-perfused capillaries, also called ghost vessels, were identified by alignment of corresponding en face AO-OCT and AO-OCTA images. The combination of multiple non-invasive imaging methods could identify prominent microscopic abnormalities in diabetic retinopathy earlier and more detailed than conventional fundus imaging devices. [ABSTRACT FROM AUTHOR]

We investigate the variability of the power emission of Io's hotspots by using recent Juno/JIRAM infrared observations. The Jovian Infrared Auroral Mapper (JIRAM) is an imaging spectrometer which began observing Jupiter in August 2016. Although observing Jupiter's moons is not its primary objective, JIRAM can use the frequent opportunities to observe Io (up to once per orbit) to gather infrared images and spectra of its surface. The present study uses the data acquired by JIRAM during the last 2 years, including the location and morphology of Io's hotspots, and the temporal variability of the total output. A new photometric model for the hotspots and the dayside surface has been developed, which permits us to disentangle the temporal variability from the changes in the observation geometry. While the latitudinal dependence of the power output is not well constrained, low-latitude hotspots show a significantly more intense temporal variability and greater temperature. [ABSTRACT FROM AUTHOR]