404 results on '"Addison B"'
Search Results
2. Condensed Phase Kinetic Studies of Hydroxynitrates Derived from the Photooxidation of Carene, Limonene, trans-Carveol, and Perillic Alcohol
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James I. Vesto, Addison B. McAlister, Kathryn A. Wright, Aaron Huang, Petra R. Baldwin, Emily J. McLaughlin Sta. Maria, Rebecca Lyn LaLonde, and Anthony J. Carrasquillo
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hydroxynitrates ,organic aerosol ,monoterpenes ,authentic standards ,Meteorology. Climatology ,QC851-999 - Abstract
Organic hydroxynitrates (HNs) are key products of hydrocarbon oxidation in the atmosphere. Understanding the fate and processing of these molecules is critical due to their function in the sequestration of NOx species from the atmosphere and in the formation of secondary organic aerosol. However, the direct study of individual HNs’ reactivity has been largely hindered by the lack of authentic standards which has further limited the ability to deconvolute the role of structural features. Herein, we report the kinetic stabilities of six biogenic volatile organic compound-derived HN in acidified single-phase organic/water matrices. Lifetimes for tertiary HNs ranged from 15 min to 6.4 h, whereas secondary HN varied from 56 days to 2.1 years. Product analysis highlights the role that additional non-hydrolysis reactions have in the condensed phase conversion of HNs. This work provides the first evidence for the structural dependence of HN stability in bulk mixed media.
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- 2022
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3. Reactivity of a Carene-Derived Hydroxynitrate in Mixed Organic/Aqueous Matrices: Applying Synthetic Chemistry to Product Identification and Mechanistic Implications
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Addison B. McAlister, James I. Vesto, Aaron Huang, Kathryn A. Wright, Emily J. McLaughlin Sta. Maria, Gabriela M. Bailey, Nicole P. Kretekos, Petra R. Baldwin, Anthony J. Carrasquillo, and Rebecca Lyn LaLonde
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hydroxynitrates 1 ,organic aerosol 2 ,hydrolysis 3 ,Meteorology. Climatology ,QC851-999 - Abstract
β-hydroxynitrates (HN) are a major class of products formed during OH and NO3 initiated oxidation of terpenes. Their production contributes significantly to secondary organic aerosol (SOA) formation and NOx sequestration. However, studying the condensed phase reactions of this important class of molecules has been hindered by the lack of commercially available authentic standards. The goal of this work was to examine the influence of water concentration and solvent identity on product yields of a tertiary HN derived from 3-carene prepared in house. To assess the role of water on conversion chemistry, bulk-phase reactions were conducted in DMSO-d6, a non-nucleophilic solvent, with a gradient of water concentrations, and analyzed with 1H NMR. Product identifications were made by comparison with authentic standards prepared in house. Four major products were identified, including an unexpected diol produced from carbocation rearrangement, diol diastereomers, and trans-3-carene oxide, with varying yields as a function of water concentration. Product yields were also measured in two protic, nucleophilic solvents, MeOD-d4 and EtOD-d6. Finally, reactions with added chloride formed alkyl chloride products in yields approaching 30%. These results are among the first to highlight the complexities of nucleophilic reactions of hydroxynitrates in bulk, mixed aqueous/organic media and to identify new, unexpected products.
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- 2021
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4. Planets around young active Solar-type stars: Assessing detection capabilities from a non stabilised spectrograph
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Heitzmann, A., Marsden, S. C., Petit, P., Mengel, M. W., Wright, D., Clerte, M., Millburn, I., Folsom, C. P., Addison, B. C., Wittenmyer, R. A., and Waite, I. A.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Short-orbit gas giant planet formation/evolution mechanisms are still not well understood. One promising pathway to discriminate between mechanisms is to constrain the occurrence rate of these peculiar exoplanets at the earliest stage of the system's life. However, a major limitation when studying newly born stars is stellar activity. This cocktail of phenomena triggered by fast rotation, strong magnetic fields and complex internal dynamics, especially present in very young stars, compromises our ability to detect exoplanets. In this paper, we investigated the limitations of such detections in the context of already acquired data solely using radial velocity data acquired with a non-stabilised spectrograph. We employed two strategies: Doppler Imaging and Gaussian Processes and could confidently detect Hot Jupiters with semi-amplitude of 100 $m.s^{-1}$ buried in the stellar activity. We also showed the advantages of the Gaussian Process approach in this case. This study serves as a proof of concept to identify potential candidates for follow-up observations or even discover such planets in legacy datasets available to the community., Comment: 16 pages, 13 figures, 11 pages appendix, accepted for publication in MNRAS
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- 2021
5. The obliquity and atmosphere of the ultra-hot Jupiter TOI-1431b (MASCARA-5b): A misaligned orbit and no signs of atomic ormolecular absorptions
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Stangret, M., Pallé, E., Casasayas-Barris, N., Oshagh, M., Bello-Arufe, A., Luque, R., Nascimbeni, V., Yan, F., Orell-Miquel, J., Sicilia, D., Malavolta, L., Addison, B. C., Buchhave, L. A., Bonomo, A. S., Borsa, F., Cabot, S. H. C., Cecconi, M., Fischer, D. A., Harutyunyan, A., Mendonça, J. M., Nowak, G., Parviainen, H., Sozzetti, A., and Tronsgaard, R.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Ultra-hot Jupiters are defined as giant planets with equilibrium temperatures larger than 2000 K. Most of them are found orbiting bright A-F type stars, making them extremely suitable objects to study their atmospheres using high-resolution spectroscopy. Recent studies show a variety of atoms and molecules detected in the atmospheres of this type of planets. Here we present our analysis of the newly discovered ultra-hot Jupiter TOI-1431b/MASCARA-5b, using two transit observations with the HARPS-N spectrograph and one transit observation with the EXPRES spectrograph. Analysis of the Rossiter-McLaughlin effect shows that the planet is in a polar orbit, with a projected obliquity $ \lambda = -155^{+20}_{-10}$ degrees. Combining the nights and applying both cross-correlation methods and transmission spectroscopy, we find no evidences of CaI, FeI, FeII, MgI, NaI, VI, TiO, VO or H$\alpha$ in the atmosphere of the planet. Our most likely explanation for the lack of atmospheric features is the large surface gravity of the planet., Comment: Accepted for publication in A&A (14 pages, 13 figures)
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- 2021
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6. Transmission spectroscopy and Rossiter-McLaughlin measurements of the young Neptune orbiting AU Mic
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Palle, E., Oshagh, M, Casasayas-Barris, N., Hirano, T., Stangret, M., Luque, R., Strachan, J., Gaidos, E., Anglada-Escude, G., Plavchan, P., and Addison, B.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
AU Mic~b is a Neptune size planet on a 8.47-day orbit around the nearest pre-main sequence ($\sim$20 Myr) star to the Sun, the bright (V=8.81) M dwarf AU Mic. The planet was preliminary detected in Doppler radial velocity time series and recently confirmed to be transiting with data from the TESS mission. AU Mic~b is likely to be cooling and contracting and might be accompanied by a second, more massive planet, in an outer orbit. Here, we present the observations of the transit of AU Mic~b using ESPRESSO on the VLT. We obtained a high-resolution time series of spectra to measure the Rossiter-McLaughlin effect and constrain the spin-orbit alignment of the star and planet, and simultaneously attempt to retrieve the planet's atmospheric transmission spectrum. These observations allow us to study for the first time the early phases of the dynamical evolution of young systems. We apply different methodologies to derive the spin-orbit angle of AU Mic~b, and all of them retrieve values consistent with the planet being aligned with the rotation plane of the star. We determine a conservative spin-orbit angle $\lambda$ value of $-2.96^{+10.44}_{-10.30}$, indicative that the formation and migration of the planets of the AU Mic system occurred within the disk. Unfortunately, and despite the large SNR of our measurements, the degree of stellar activity prevented us from detecting any features from the planetary atmosphere. In fact, our results suggest that transmission spectroscopy for recently formed planets around active young stars is going to remain very challenging, if at all possible, for the near future., Comment: Submitted to A&A, under second review
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- 2020
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7. A Beefy-R culture medium: Replacing albumin with rapeseed protein isolates
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Stout, Andrew J., Rittenberg, Miriam L., Shub, Michelle, Saad, Michael K., Mirliani, Addison B., Dolgin, James, and Kaplan, David L.
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- 2023
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8. General practice-based undergraduate pharmacy longitudinal clerkship: a theoretically underpinned qualitative evaluation
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Innes, C., Cunningham, S., Addison, B., Wedekind, Y., Watson, E., Rudd, I., Power, A., Karim, L., and Rushworth, G. F.
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- 2022
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9. HATS-60b - HATS-69b: Ten Transiting Planets From HATSouth
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Hartman, J. D., Bakos, G. A., Bayliss, D., Bento, J., Bhatti, W., Brahm, R., Csubry, Z., Espinoza, N., Henning, Th., Jordán, A., Mancini, L., Penev, K., Rabus, M., Sarkis, P., Suc, V., de Val-Borro, M., Zhou, G., Addison, B., Arriagada, P., Butler, R. P., Crane, J., Durkan, S., Shectman, S., Tan, T. G., Thompson, I., Tinney, C. G., Wright, D. J., Lázár, J., Papp, I., and Sári, P.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery of ten transiting extrasolar planets by the HATSouth survey. The planets range in mass from the Super-Neptune HATS-62b, with $M_{p} < 0.179 M_{J}$, to the Super-Jupiter HATS-66b, with $M_{p} = 5.33 M_{J}$, and in size from the Saturn HATS-69b, with $R_{p} = 0.94 R_{J}$, to the inflated Jupiter HATS-67b, with $R_{p} = 1.69 R_{J}$. The planets have orbital periods between 1.6092 days (HATS-67b) and 7.8180 days (HATS-61b). The hosts are dwarf stars with masses ranging from $0.89 M_{\odot}$ (HATS-69) to $1.56 M_{\odot}$ (HATS-64), and have apparent magnitudes between $V = 12.276 \pm 0.020$ mag (HATS-68) and $V = 14.095 \pm 0.030$ mag (HATS-66). The Super-Neptune HATS-62b is the least massive planet discovered to date with a radius larger than Jupiter. Based largely on the Gaia DR2 distances and broad-band photometry, we identify three systems (HATS-62, -64, and -65) as having possible unresolved binary star companions. We discuss in detail our methods for incorporating the Gaia DR2 observations into our modeling of the system parameters, and into our blend analysis procedures., Comment: Replaced with version accepted for publication in AJ, some changes to parameter values compared to previous version, 41 pages, 12 figures, 19 Tables
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- 2018
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10. Stellar Obliquities & Planetary Alignments (SOPA) I. Spin-Orbit measurements of Three Transiting Hot Jupiters: WASP-72b, WASP-100b, & WASP-109b
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Addison, B. C., Wang, S., Johnson, M. C., Tinney, C. G., Wright, D. J., and Bayliss, D.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report measurements of the sky-projected spin--orbit angles for three transiting hot Jupiters: two of which are in nearly polar orbits, WASP-100b and WASP-109b, and a third in a low obliquity orbit, WASP-72b. We obtained these measurements by observing the Rossiter--McLaughlin effect over the course of the transits from high resolution spectroscopic observations made with the CYCLOPS2 optical fiber bundle system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The resulting sky-projected spin--orbit angles are $\lambda = {-7^{\circ}}^{+11^{\circ}}_{-12^{\circ}}$, $\lambda = {79^{\circ}}^{+19^{\circ}}_{-10^{\circ}}$, and $\lambda = {99^{\circ}}^{+10^{\circ}}_{-9^{\circ}}$ for WASP-72b, WASP-100b, and WASP-109b, respectively. These results suggests that WASP-100b and WASP-109b are on highly inclined orbits tilted nearly $90^{\circ}$ from their host star's equator while the orbit of WASP-72b appears to be well-aligned. WASP-72b is a typical hot Jupiter orbiting a mid-late F star (F7 with $T_\mathrm{{eff}}=6250\pm120$K). WASP-100b and WASP-109b are highly irradiated bloated hot Jupiters orbiting hot early-mid F stars (F2 with $T_\mathrm{{eff}}=6900\pm120$K and F4 with $T_\mathrm{{eff}}=6520\pm140$K), making them consistent with the trends observed for the majority of stars hosting planets on high-obliquity orbits., Comment: 10 pages, 10 figures, 6 tables. Has been accepted for publication in The Astronomical Journal
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- 2018
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11. HATS-59b,c: A Transiting Hot Jupiter and a Cold Massive Giant Planet Around a Sun-Like Star
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Sarkis, P., Henning, Th., Hartman, J. D., Bakos, G. Á., Brahm, R., Jordán, A., Bayliss, D., Mancini, L., Espinoza, N., Rabus, M., Csubry, Z., Bhatti, W., Penev, K., Zhou, G., Bento, J., Tan, T. G., Arriagada, P., Butler, R. P., Crane, J. D., Shectman, S., Tinney, C. G., Wright, D. J., Addison, B., Durkan, S., Suc, V., Buchhave, L. A., de Val-Borro, M., Lázár, J., Papp, I., and Sári, P.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the first discovery of a multi-planetary system by the HATSouth network, HATS-59b,c, a planetary system with an inner transiting hot Jupiter and an outer cold massive giant planet, which was detected via radial velocity. The inner transiting planet, HATS-59b, is on an eccentric orbit with $e = 0.129\pm0.049$, orbiting a $V=13.951\pm0.030$ mag solar-like star ($M_* = 1.038\pm0.039 M_{\odot}$, and $R_* = 1.036\pm0.067 R_{\odot}$) with a period of $5.416077\pm0.000017$ days. The outer companion, HATS-59c is on a circular orbit with $ m \sin i = 12.8\pm1.1 M_\mathrm{J}$, and a period of $1422\pm14$ days. The inner planet has a mass of $0.806\pm0.069 M_\mathrm{J}$ and a radius of $1.126\pm0.077 M_\mathrm{J}$, yielding a density of $0.70\pm0.16 {\rm g\,cm^{-3}}$. Unlike most of the planetary systems that include only a single hot Jupiter, HATS-59b,c includes, in addition to the transiting hot Jupiter, a massive outer companion. The architecture of this system is valuable for understanding planet migration., Comment: 12 pages, 9 figures, submitted to AJ. For a short discussion, see https://sites.google.com/view/paulasarkis/research/hats-59
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- 2018
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12. Simple and effective serum-free medium for sustained expansion of bovine satellite cells for cell cultured meat
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Stout, Andrew J., Mirliani, Addison B., Rittenberg, Miriam L., Shub, Michelle, White, Eugene C., Yuen, Jr., John S. K., and Kaplan, David L.
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- 2022
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13. Rab35 Is Required for Embryonic Development and Kidney and Ureter Homeostasis through Regulation of Epithelial Cell Junctions
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Clearman, Kelsey R., primary, Timpratoom, Napassawon, additional, Patel, Dharti, additional, Rains, Addison B., additional, Haycraft, Courtney J., additional, Croyle, Mandy J., additional, Reiter, Jeremy F., additional, and Yoder, Bradley K., additional
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- 2024
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14. Spin-orbit alignments for Three Transiting Hot Jupiters: WASP-103b, WASP-87b, & WASP-66b
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Addison, B. C., Tinney, C. G., Wright, D. J., and Bayliss, D.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We have measured the sky-projected spin-orbit alignments for three transiting Hot Jupiters, WASP-103b, WASP-87b, and WASP-66b, using spectroscopic measurements of the Rossiter-McLaughlin effect, with the CYCLOPS2 optical-fiber bundle system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The resulting sky projected spin-orbit angles of $\lambda = 3^{\circ}\pm33^{\circ}$, $\lambda = -8^{\circ}\pm11^{\circ}$, and $\lambda = -4^{\circ}\pm22^{\circ}$ for WASP-103b, WASP-87b, and WASP-66b, respectively, suggest that these three planets are likely on nearly aligned orbits with respect to their host star's spin axis. WASP-103 is a particularly interesting system as its orbital distance is only 20% larger than its host star's Roche radius and the planet likely experiences strong tidal effects. WASP-87 and WASP-66 are hot ($T_{eff}=6450\pm120$ K and $T_{eff}=6600\pm150$ K, respectively) mid-F stars making them similar to the majority of stars hosting planets on high obliquity orbits. Moderate spin-orbit misalignments for WASP-103b and WASP-66b are consistent with our data, but polar and retrograde orbits are not favored for these systems., Comment: Published in the Astrophysical Journal. 18 pages, 8 figures, and 9 tables
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- 2016
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15. HATS-13b and HATS-14b: two transiting hot Jupiters from the HATSouth survey
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Mancini, L., Hartman, J. D., Penev, K., Bakos, G. A., Brahm, R., Ciceri, S., Henning, Th., Csubry, Z., Bayliss, D., Zhou, G., Rabus, M., de Val-Borro, M., Espinoza, N., Jordan, A., Suc, V., Bhatti, W., Schmidt, B., Sato, B., Tan, T. G., Wright, D. J., Tinney, C. G., Addison, B. C., Noyes, R. W., Lazar, J., Papp, I., and Sari, P.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery of HATS-13b and HATS-14b, two hot-Jupiter transiting planets discovered by the HATSouth survey. The host stars are quite similar to each other (HATS-13: V = 13.9 mag, M* = 0.96 Msun, R* = 0.89 Rsun, Teff = 5500 K, [Fe/H] = 0.05; HATS-14: V = 13.8 mag, M* = 0.97 Msun, R* = 0.93 Rsun, Teff = 5350 K, [Fe/H] = 0.33) and both the planets orbit around them with a period of roughly 3 days and a separation of roughly 0.04 au. However, even though they are irradiated in a similar way, the physical characteristics of the two planets are very different. HATS-13b, with a mass of Mp = 0.543 MJ and a radius of Rp = 1.212 RJ, appears as an inflated planet, while HATS-14b, having a mass of Mp = 1.071 MJ and a radius of Rp = 1.039 RJ, is only slightly larger in radius than Jupiter., Comment: 13 pages, 7 figures, Submitted to Astronomy & Astrophysics. arXiv admin note: text overlap with arXiv:1503.00062
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- 2015
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16. Engineering carotenoid production in mammalian cells for nutritionally enhanced cell-cultured foods
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Stout, Andrew J., Mirliani, Addison B., Soule-Albridge, Erin L., Cohen, Julian M., and Kaplan, David L.
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- 2020
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17. A Spin-Orbit Alignment for the Hot Jupiter HATS-3b
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Addison, B. C., Tinney, C. G., Wright, D. J., and Bayliss, D.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We have measured the alignment between the orbit of HATS-3b (a recently discovered, slightly inflated Hot Jupiter) and the spin-axis of its host star. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The sky-projected spin-orbit angle of $\lambda = 3\pm25^{\circ}$ was determined from spectroscopic measurements of Rossiter-McLaughlin effect. This is the first exoplanet discovered through the HATSouth transit survey to have its spin-orbit angle measured. Our results indicate that the orbital plane of HATS-3b is consistent with being aligned to the spin axis of its host star. The low obliquity of the HATS-3 system, which has a relatively hot mid F-type host star, agrees with the general trend observed for Hot Jupiter host stars with effective temperatures $>6250$K to have randomly distributed spin-orbit angles., Comment: 13 pages. Accepted for publication in the Astrophysical Journal
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- 2014
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18. A Nearly Polar Orbit for the Extrasolar Hot Jupiter WASP-79b
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Addison, B. C., Tinney, C. G., Wright, D. J., Bayliss, D., Zhou, G., Hartman, J. D., Bakos, G. Á., and Schmidt, B.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the measurement of a spin-orbit misalignment for WASP-79b, a recently discovered, bloated transiting hot Jupiter from the WASP survey. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. We have used the Rossiter-McLaughlin effect to determine the sky-projected spin-orbit angle to be lambda = -106+19-13 degrees. This result indicates a significant misalignment between the spin axis of the host star and the orbital plane of the planet -- the planet being in a nearly polar orbit. WASP-79 is consistent with other stars that have Teff > 6250K and host hot Jupiters in spin-orbit misalignment., Comment: 8 pages, 2 figures, in press ApJL (accepted 2 August 2013)
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- 2013
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19. HATS-3b: An inflated hot Jupiter transiting an F-type star
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Bayliss, D., Zhou, G., Penev, K., Bakos, G., Hartman, J., Jordán, A., Mancini, L., Mohler, M., Suc, V., Rabus, M., Béky, B., Csubry, Z., Buchhave, L., Henning, T., Nikolov, N., Csák, B., Brahm, R., Espinoza, N., Noyes, R., Schmidt, B., Conroy, P., Wright, D., Tinney, C., Addison, B., Sackett, P., Sasselov, D., Lázár, J., Papp, I., and Sári, P.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery by the HATSouth survey of HATS-3b, a transiting extrasolar planet orbiting a V=12.4 F-dwarf star. HATS-3b has a period of P = 3.5479d, mass of Mp = 1.07MJ, and radius of Rp = 1.38RJ. Given the radius of the planet, the brightness of the host star, and the stellar rotational velocity (vsini = 9.0km/s), this system will make an interesting target for future observations to measure the Rossiter-McLaughlin effect and determine its spin-orbit alignment. We detail the low/medium-resolution reconnaissance spectroscopy that we are now using to deal with large numbers of transiting planet candidates produced by the HATSouth survey. We show that this important step in discovering planets produces logg and Teff parameters at a precision suitable for efficient candidate vetting, as well as efficiently identifying stellar mass eclipsing binaries with radial velocity semi-amplitudes as low as 1 km/s., Comment: 11 pages, 10 figures, submitted to AJ
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- 2013
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20. HATS-2b: A transiting extrasolar planet orbiting a K-type star showing starspot activity
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Mohler-Fischer, M., Mancini, L., Hartman, J. D., Bakos, G. B., Penev, K., Bayliss, D., Jordan, A., Csubry, Z., Zhou, G., Rabus, M., Nikolov, N., Brahm, R., Espinoza, N., Buchhave, L. A., Beky, B., Suc, V., Csak, B., Henning, T., Wright, D. J., Tinney, C. G., Addison, B. C., Schmidt, B., Noyes, R. W., Papp, I., Lazar, J., Sari, P., and Conroy, P.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery of HATS-2b, the second transiting extrasolar planet detected by the HATSouth survey. HATS-2b is moving on a circular orbit around a V=13.6 mag, K-type dwarf star (GSC 6665-00236), at a separation of 0.0230 \pm 0.0003 AU and with a period of 1.3541 days. The planetary parameters have been robustly determined using a simultaneous fit of the HATSouth, MPG/ESO~2.2\,m/GROND, Faulkes Telescope South/Spectral transit photometry and MPG/ESO~2.2\,m/FEROS, Euler~1.2\,m/CORALIE, AAT~3.9\,m/CYCLOPS radial-velocity measurements. HATS-2b has a mass of 1.37 \pm 0.16 M_J, a radius of 1.14 \pm 0.03 R_J and an equilibrium temperature of 1567 \pm 30 K. The host star has a mass of 0.88 \pm 0.04 M_Sun, radius of 0.89 \pm 0.02 R_Sun and shows starspot activity. We characterized the stellar activity by analysing two photometric follow-up transit light curves taken with the GROND instrument, both obtained simultaneously in four optical bands (covering the wavelength range of 3860-9520 \AA). The two light curves contain anomalies compatible with starspots on the photosphere of the parent star along the same transit chord., Comment: 13 pages, 8 figures, accepted by A&A
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- 2013
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21. Immortalized Bovine Satellite Cells for Cultured Meat Applications
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Andrew J. Stout, Miles J. Arnett, Kristin Chai, Tina Guo, Lishu Liao, Addison B. Mirliani, Miriam L. Rittenberg, Michelle Shub, Eugene C. White, John S. K. Yuen, Xiaoli Zhang, and David L. Kaplan
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Biomedical Engineering ,General Medicine ,Biochemistry, Genetics and Molecular Biology (miscellaneous) - Abstract
For cultured meat to succeed at scale, muscle cells from food-relevant species must be expandedin vitroin a rapid and reliable manner to produce millions of metric tons of biomass annually. Toward this goal, genetically immortalized cells offer substantial benefits over primary cells, including rapid growth, escape from cellular senescence, and consistent starting cell populations for production. Here, we develop genetically immortalized bovine satellite cells (iBSCs) via constitutive expression of bovine Telomerase reverse transcriptase (TERT) and Cyclin-dependent kinase 4 (CDK4). These cells achieve over 120 doublings at the time of publication and maintain their capacity for myogenic differentiation. They therefore offer a valuable tool to the field, enabling further research and development to advance cultured meat.
- Published
- 2023
22. Is SBRT Boost Feasible for PET Positive Lymph Nodes for Cervical Cancer? Evaluation using Tumor Control Probability and QUANTEC Criteria
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Snyder, Jeffrey E., Willett, Addison B., Sun, Wenqing, and Kim, Yusung
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- 2019
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23. HATS-1b: The First Transiting Planet Discovered by the HATSouth Survey
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Penev, K., Bakos, G. Á., Bayliss, D., Jordán, A., Mohler, M., Zhou, G., Suc, V., Rabus, M., Hartman, J. D., Mancini, L., Béky, B., Csubry, Z., Buchhave, L., Henning, T., Nikolov, N., Csák, B., Brahm, R., Espinoza, N., Conroy, P., Noyes, R. W., Sasselov, D. D., Schmidt, B., Wright, D. J., Tinney, C. G., Addison, B. C., Lázár, J., Papp, I., and Sári, P.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery of HATS-1b, a transiting extrasolar planet orbiting the moderately bright V=12.05 G dwarf star GSC 6652-00186, and the first planet discovered by HATSouth, a global network of autonomous wide-field telescopes. HATS-1b has a period P~3.4465 d, mass Mp~1.86MJ, and radius Rp~1.30RJ. The host star has a mass of 0.99Msun, and radius of 1.04Rsun. The discovery light curve of HATS-1b has near continuous coverage over several multi-day periods, demonstrating the power of using a global network of telescopes to discover transiting planets., Comment: Submitted to AJ 10 pages, 5 figures, 6 tables
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- 2012
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24. Two mini-Neptunes Transiting the Adolescent K-star HIP 113103 Confirmed with TESS and CHEOPS
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Lowson, N, primary, Zhou, G, additional, Huang, C X, additional, Wright, D J, additional, Edwards, B, additional, Nabbie, E, additional, Venner, A, additional, Quinn, S N, additional, Collins, K A, additional, Gillen, E, additional, Battley, M, additional, Triaud, A, additional, Hellier, C, additional, Seager, S, additional, Winn, J N, additional, Jenkins, J M, additional, Wohler, B, additional, Shporer, A, additional, Schwarz, R P, additional, Murgas, F, additional, Pallé, E, additional, Anderson, D R, additional, West, R G, additional, Wittenmyer, R A, additional, Bowler, B P, additional, Horner, J, additional, Kane, S R, additional, Kielkopf, J, additional, Plavchan, P, additional, Zhang, H, additional, Fairnington, T, additional, Okumura, J, additional, Mengel, M W, additional, and Addison, B C, additional
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- 2023
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25. Rab35 is required for embryonic development and kidney and ureter homeostasis through regulation of epithelial cell junctions
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Clearman, Kelsey R, primary, Timpratoom, Napassawon, additional, Patel, Dharti, additional, Rains, Addison B, additional, Haycraft, Courtney J R, additional, Croyle, Mandy J, additional, Reiter, Jeremy F., additional, and Yoder, Bradley K, additional
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- 2023
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26. Immortalized Bovine Satellite Cells for Cultured Meat Applications
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Stout, Andrew J., primary, Arnett, Miles J., additional, Chai, Kristin, additional, Guo, Tina, additional, Liao, Lishu, additional, Mirliani, Addison B., additional, Rittenberg, Miriam L., additional, Shub, Michelle, additional, White, Eugene C., additional, Yuen, John S. K., additional, Zhang, Xiaoli, additional, and Kaplan, David L., additional
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- 2023
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27. Degradations of Trust in Automation Associated with Repeated Monitoring Checks
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Bright, Addison B., primary, Cotter, Jenna E., additional, and Tenhundfeld, Nathan L., additional
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- 2023
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28. A sub-Neptune transiting the young field star HD 18599 at 40 pc
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de Leon, J P, primary, Livingston, J H, additional, Jenkins, J S, additional, Vines, J I, additional, Wittenmyer, R A, additional, Clark, J T, additional, Winn, J I M, additional, Addison, B, additional, Ballard, S, additional, Bayliss, D, additional, Beichman, C, additional, Benneke, B, additional, Berardo, D A, additional, Bowler, B P, additional, Brown, T, additional, Bryant, E M, additional, Christiansen, J, additional, Ciardi, D, additional, Collins, K A, additional, Collins, K I, additional, Crossfield, I, additional, Deming, D, additional, Dragomir, D, additional, Dressing, C D, additional, Fukui, A, additional, Gan, T, additional, Giacalone, S, additional, Gill, S, additional, Gorjian, V, additional, González Alvarez, E, additional, Hesse, K, additional, Horner, J, additional, Howell, S B, additional, Jenkins, J M, additional, Kane, S R, additional, Kendall, A, additional, Kielkopf, J F, additional, Kreidberg, L, additional, Latham, D W, additional, Liu, H, additional, Lund, M B, additional, Matson, R, additional, Matthews, E, additional, Mengel, M W, additional, Morales, F, additional, Mori, M, additional, Narita, N, additional, Nishiumi, T, additional, Okumura, J, additional, Plavchan, P, additional, Quinn, S, additional, Rabus, M, additional, Ricker, G, additional, Rudat, A, additional, Schlieder, J, additional, Schwarz, R P, additional, Seager, S, additional, Shporer, A, additional, Smith, A M S, additional, Stassun, K, additional, Tamura, M, additional, Tan, T G, additional, Tinney, C, additional, Vanderspek, R, additional, Werner, M W, additional, West, R G, additional, Wright, D, additional, Zhang, H, additional, and Zhou, G, additional
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- 2023
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29. Degradations of Trust in Automation Associated with Repeated Monitoring Checks
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Addison B. Bright, Jenna E. Cotter, and Nathan L. Tenhundfeld
- Published
- 2023
30. Across the North Pacific, dietary-induced stress of breeding rhinoceros auklets increases with high summer Pacific Decadal Oscillation index
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Shimabukuro, U, primary, Takahashi, A, additional, Okado, J, additional, Kokubun, N, additional, Thiebot, JB, additional, Will, A, additional, Watanuki, Y, additional, Addison, B, additional, Hatch, SA, additional, Hipfner, JM, additional, Slater, L, additional, Drummond, BA, additional, and Kitaysky, AS, additional
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- 2023
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31. Immortalized bovine satellite cells for cultured meat applications
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Stout, Andrew J., primary, Arnett, Miles J., additional, Chai, Kristin M., additional, Guo, Tina, additional, Liao, Lishu, additional, Mirliani, Addison B., additional, Rittenberg, Miriam L., additional, Shub, Michelle, additional, White, Eugene C., additional, Yuen, John S. K., additional, Zhang, Xiaoli, additional, and Kaplan, David L., additional
- Published
- 2022
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32. Interprofessional education during experiential learning placements for student pharmacists in Scotland. Exploring current support provision and stakeholder views
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Depasquale, C, primary, Cunningham, S, additional, Boyter, A, additional, Jacob, S A, additional, Power, A, additional, Portlock, J, additional, and Addison, B, additional
- Published
- 2022
- Full Text
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33. A Beefy-R culture medium: replacing albumin with rapeseed protein isolates
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Andrew J. Stout, Miriam L. Rittenberg, Michelle Shub, Michael K. Saad, Addison B. Mirliani, and David L. Kaplan
- Abstract
The development of cost-effective serum-free media is essential for the economic viability of cultured meat. A key challenge facing this goal is high-cost recombinant albumin that is necessary in some available serum-free media formulations. As such, there is substantial interest in finding albumin alternatives which are low-cost, effective, scalable, sustainable, and suitable for food applications. Recently, a serum-free medium termed Beefy-9 was developed for bovine satellite cells (BSCs), which relied on recombinant albumin as a key component to replace fetal bovine serum. Here we alter Beefy-9 by replacing albumin with rapeseed protein isolate, a bulk-protein solution obtained from agricultural waste-streams through simple isoelectric protein precipitation. This new medium, termed Beefy-R, improves BSC growth compared with Beefy-9 while maintaining cell phenotype and myogenicity. These results offer an effective, low-cost, and sustainable alternative to albumin for serum-free culture of muscle stem cells, thereby addressing a key hurdle facing cultured meat production.
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- 2022
34. A Beefy-R culture medium: replacing albumin with rapeseed protein isolates
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Stout, Andrew J., primary, Rittenberg, Miriam L., additional, Shub, Michelle, additional, Saad, Michael K., additional, Mirliani, Addison B., additional, and Kaplan, David L., additional
- Published
- 2022
- Full Text
- View/download PDF
35. A Beefy-R culture medium: Replacing albumin with rapeseed protein isolates
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Andrew J. Stout, Miriam L. Rittenberg, Michelle Shub, Michael K. Saad, Addison B. Mirliani, James Dolgin, and David L. Kaplan
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Biomaterials ,Mechanics of Materials ,Biophysics ,Ceramics and Composites ,Bioengineering - Published
- 2023
36. Reducing anticholinergic medication exposure among older adults using consumer technology: Protocol for a randomized clinical trial
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Jordan R. Hill, Ephrem Abebe, Khalid A. Alamer, Wanzhu Tu, Christian Vallejo, Philip Adeoye, Robin Valenzuela, Noll L. Campbell, Daniel O. Clark, Richard J. Holden, Ziyi Yang, Alexxus Knight, Addison B. Harrington, Na Bo, Kimberly S. Trowbridge, Gracen O'Neal, Malaz Boustani, and Allie Carter
- Subjects
medicine.medical_specialty ,Psychological intervention ,Pharmaceutical Science ,Pharmacy ,030204 cardiovascular system & hematology ,Drug Prescriptions ,Medication prescription ,Article ,Cholinergic Antagonists ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Randomized controlled trial ,law ,medicine ,Humans ,030212 general & internal medicine ,Aged ,Randomized Controlled Trials as Topic ,Polypharmacy ,Primary Health Care ,business.industry ,Clinical trial ,Quality of Life ,Physical therapy ,Independent Living ,Deprescribing ,business ,Medication list - Abstract
Introduction A growing body of scientific evidence points to the potentially harmful cognitive effects of anticholinergic medications among older adults. Most interventions designed to promote deprescribing of anticholinergics have directly targeted healthcare professionals and have had mixed results. Consumer-facing technologies may provide a unique benefit by empowering patients and can complement existing healthcare professional-centric efforts. Methods We initiated a randomized clinical trial to evaluate the effectiveness of a patient-facing mobile application (Brain Safe app) compared to an attention control medication list app in reducing anticholinergic exposure among community-dwelling older adults. Study participants are adults aged 60 years and above, currently using at least one prescribed strong anticholinergic, and receiving primary care. The trial plans to enroll a total of 700 participants, randomly allocated in 1:1 proportion to the two study arms. Participants will have the Brain Safe app (intervention arm) or attention control medication list app (control arm) loaded onto a smartphone (study provided or personal device). All participants will be followed for 12 months and will have data collected at baseline, at 6 months, and 12 months by blinded outcome assessors. The primary outcome of the study is anticholinergic exposure measured as total standard daily dose (TSDD) computed from medication prescription electronic records. Secondary outcomes of the study are cognitive function and health-related quality of life. Discussion A consumer-facing intervention to promote deprescribing of potentially high-risk medications can be part of a multi-pronged approach to reduce inappropriate medication use among older adult patients. Delivering a deprescribing intervention via a mobile app is a novel approach and may hold great promise to accelerate deployment of medication safety initiatives across diverse patient populations. Clinical trial registration Registered at ClinicalTrials.gov on October 10, 2019. Identifier number: NCT04121858.
- Published
- 2021
37. Engineering carotenoid production in mammalian cells for nutritionally enhanced cell-cultured foods
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Erin L. Soule-Albridge, Julian M. Cohen, David L. Kaplan, Andrew J. Stout, and Addison B. Mirliani
- Subjects
0106 biological sciences ,Nutritional engineering ,Cultivated meat ,Bioengineering ,Biology ,01 natural sciences ,Applied Microbiology and Biotechnology ,Regenerative medicine ,Article ,Metabolic engineering ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Cultured meat ,Lycopene ,Phytoene ,010608 biotechnology ,Animals ,Carotenoid ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,beta Carotene ,Carotenoids ,Enzyme ,Biopharmaceutical ,Metabolic Engineering ,Biochemistry ,chemistry ,Cell culture ,Cell-based meat ,Cattle ,Fermented Foods ,Cellular agriculture ,In vitro meat ,Biotechnology - Abstract
Metabolic engineering of mammalian cells has to-date focused primarily on biopharmaceutical protein production or the manipulation of native metabolic processes towards therapeutic aims. However, significant potential exists for expanding these techniques to diverse applications by looking across the taxonomic tree to bioactive metabolites not synthesized in animals. Namely, cross-taxa metabolic engineering of mammalian cells could offer value in applications ranging food and nutrition to regenerative medicine or gene therapy. Towards the former, recent advances in meat production through cell culture suggest the potential to produce meat with fine cellular control, where tuning composition through cross-taxa metabolic engineering could enhance nutrition and food-functionality. Here we demonstrate this possibility by engineering primary bovine and immortalized murine muscle cells with prokaryotic enzymes to endogenously produce the antioxidant carotenoids phytoene, lycopene and β-carotene. These phytonutrients offer general nutritive value and protective effects against diseases associated with red and processed meat consumption, and so offer a promising proof-of-concept for nutritional engineering in cultured meat. We demonstrate the phenotypic integrity of engineered cells, the ability to tune carotenoid yields, and antioxidant functionality of these compounds in vitro towards both nutrition and food-quality objectives. Our results demonstrate the potential for tailoring the nutritional profile of cultured meats. They further lay a foundation for heterologous metabolic engineering of mammalian cells for applications outside of the clinical realm., This document is the Authors Accepted Manuscript (or "postprint") and may have minor differences from the Version of Record due to final copyedits. The final published version can be accessed at https://doi.org/10.1016/j.ymben.2020.07.011.
- Published
- 2020
38. Convergence Across Behavioral and Self-report Measures Evaluating Individuals' Trust in an Autonomous Golf Cart
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Jenna E. Cotter, Emily H. O'Hear, R. Cooper Smitherman, Addison B. Bright, Nathan L. Tenhundfeld, Jason Forsyth, Nathan R. Sprague, and Samy El-Tawab
- Published
- 2022
39. Convergence Across Behavioral and Self-report Measures Evaluating Individuals' Trust in an Autonomous Golf Cart
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Cotter, Jenna E., primary, O'Hear, Emily H., additional, Smitherman, R. Cooper, additional, Bright, Addison B., additional, Tenhundfeld, Nathan L., additional, Forsyth, Jason, additional, Sprague, Nathan R., additional, and El-Tawab, Samy, additional
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- 2022
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- View/download PDF
40. Condensed Phase Kinetic Studies of Hydroxynitrates Derived from the Photooxidation of Carene, Limonene, trans-Carveol, and Perillic Alcohol
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Vesto, James I., primary, McAlister, Addison B., additional, Wright, Kathryn A., additional, Huang, Aaron, additional, Baldwin, Petra R., additional, McLaughlin Sta. Maria, Emily J., additional, LaLonde, Rebecca Lyn, additional, and Carrasquillo, Anthony J., additional
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- 2022
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41. Reactivity of a Carene-Derived Hydroxynitrate in Mixed Organic/Aqueous Matrices: Applying Synthetic Chemistry to Product Identification and Mechanistic Implications
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McAlister, Addison B., primary, Vesto, James I., additional, Huang, Aaron, additional, Wright, Kathryn A., additional, McLaughlin Sta. Maria, Emily J., additional, Bailey, Gabriela M., additional, Kretekos, Nicole P., additional, Baldwin, Petra R., additional, Carrasquillo, Anthony J., additional, and LaLonde, Rebecca Lyn, additional
- Published
- 2021
- Full Text
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42. The obliquity and atmosphere of the ultra-hot Jupiter TOI-1431b (MASCARA-5b): A misaligned orbit and no signs of atomic or molecular absorptions
- Author
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Stangret, M., primary, Pallé, E., additional, Casasayas-Barris, N., additional, Oshagh, M., additional, Bello-Arufe, A., additional, Luque, R., additional, Nascimbeni, V., additional, Yan, F., additional, Orell-Miquel, J., additional, Sicilia, D., additional, Malavolta, L., additional, Addison, B. C., additional, Buchhave, L. A., additional, Bonomo, A. S., additional, Borsa, F., additional, Cabot, S. H. C., additional, Cecconi, M., additional, Fischer, D. A., additional, Harutyunyan, A., additional, Mendonça, J. M., additional, Nowak, G., additional, Parviainen, H., additional, Sozzetti, A., additional, and Tronsgaard, R., additional
- Published
- 2021
- Full Text
- View/download PDF
43. Dietary segregation between two cohabiting species of sparrows revealed with stable isotope analysis
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Hipfner, J.M., Addison, B., and Charette, M.R.
- Subjects
Animal feeding behavior -- Research ,Zoology and wildlife conservation - Abstract
Fox Sparrows (Passerella iliaca (Merrem, 1786)) and Song Sparrows (Melospiza melodia (A. Wilson, 1810)) cohabit on many islands along the Pacific coast of North America, and previous studies suggest that they rely on similar prey types. We used δ[sup.13]C and δ[sup.15]N stable isotope analysis on blood collected from breeding adults of both species in each of two habitats on Triangle Island, British Columbia, Canada, to test the hypothesis that the two species exhibit a consistent pattern (direction) of dietary segregation in different habitat types. Both δ[sup.13]C and especially δ[sup.15]N values differed between habitats, indicating that the two habitats were isotopically distinct. As predicted, δ[sup.15]N values differed consistently between the two species in the two habitats, averaging ~1.5 higher in the smaller Song Sparrow than in the larger Fox Sparrow in both. We infer that Song Sparrows included more animal matter and less plant matter in their diets than Fox Sparrows, and suggest that fixed traits related to body size might underlie the dietary (trophic) differences. In contrast, δ[sup.13]C values did not differ between species. We conclude that dietary segregation could help to facilitate the widespread cohabitation of these two species of sparrows. Key words: cohabitation, dietary segregation, Fox Sparrow, Melospiza melodia, Passerella iliaca, Song Sparrow, stable isotopes. Les bruants fauves (Passerella iliaca (Merrem, 1786)) et les bruants chanteurs (Melospiza melodia (A. Wilson, 1810)) cohabitent dans de nombreuses iles de la cote du Pacifique de l'Amerique du Nord, et des etudes anterieures laissent croire qu'ils dependent de types de proies semblables. Nous avons analyse les isotopes stables du carbone et de l'azote (δ[sup.13]C et δ[sup.15]N) de sang preleve d'adultes reproducteurs des deux especes dans deux habitats distincts de l'ile Triangle, en Colombie- Britannique (Canada) afin de verifier l'hypothese voulant que les deux especes presentent un patron (direction) coherent de segregation alimentaire dans differents types d'habitats. Les valeurs de δ[sup.13]C et particulierement de δ[sup.15]N variaient selon l'habitat, indiquant que les deux habitats sont differents sur le plan isotopique. Comme prevu, les valeurs de δ[sup.15]N presentaient des differences coherentes entre les deux especes dans les deux habitats, les valeurs du bruant chanteur, le plus petit des deux oiseaux, etant en moyenne de ~1,5[por millar] superieures a celles du bruant fauve dans les deux habitats. Nous en concluons que le regime des bruants chanteurs comprend plus de matiere animale et moins de matiere vegetale que celui des bruants fauves et postulons que des caracteres fixes lies a la taille du corps pourraient sous-tendre ces differences alimentaires (trophiques). En revanche, les valeurs de δ[sup.13]C des deux especes etaient semblables. Nous concluons que la segregation alimentaire pourrait faciliter la cohabitation a grande echelle de ces deux especes de bruants. [Traduit par la Redaction] Mots-cles: cohabitation, segregation alimentaire, bruant fauve, Melospiza melodia, Passerella iliaca, bruant chanteur, isotopes stables., Introduction There is a wide variety of mechanisms that might enable potential competitors to cohabit (Chesson 2000). These mechanisms include frequency-dependent predation (Holt 1977), temporal segregation in the period of [...]
- Published
- 2013
- Full Text
- View/download PDF
44. Famous Men of the Middle Ages
- Author
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Addison B. Poland and Addison B. Poland
- Published
- 2003
45. Planets around young active solar-type stars: assessing detection capabilities from a non-stabilized spectrograph
- Author
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Heitzmann, A, primary, Marsden, S C, additional, Petit, P, additional, Mengel, M W, additional, Wright, D, additional, Clerte, M, additional, Millburn, I, additional, Folsom, C P, additional, Addison, B C, additional, Wittenmyer, R A, additional, and Waite, I A, additional
- Published
- 2021
- Full Text
- View/download PDF
46. Simple and effective serum-free medium for sustained expansion of bovine satellite cells for cell cultured meat
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Stout, Andrew J., primary, Mirliani, Addison B., additional, White, Eugene C., additional, Yuen, John S.K., additional, and Kaplan, David L., additional
- Published
- 2021
- Full Text
- View/download PDF
47. Reducing anticholinergic medication exposure among older adults using consumer technology: Protocol for a randomized clinical trial
- Author
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Abebe, Ephrem, primary, Campbell, Noll L., additional, Clark, Daniel O., additional, Tu, Wanzhu, additional, Hill, Jordan R., additional, Harrington, Addison B., additional, O'Neal, Gracen, additional, Trowbridge, Kimberly S., additional, Vallejo, Christian, additional, Yang, Ziyi, additional, Bo, Na, additional, Knight, Alexxus, additional, Alamer, Khalid A., additional, Carter, Allie, additional, Valenzuela, Robin, additional, Adeoye, Philip, additional, Boustani, Malaz A., additional, and Holden, Richard J., additional
- Published
- 2021
- Full Text
- View/download PDF
48. TOI-257b (HD 19916b): A warm sub-saturn orbiting an evolved F-type star
- Author
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National Aeronautics and Space Administration (US), National Science Foundation (US), Danish National Research Foundation, National Natural Science Foundation of China, Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, European Commission, Centre National D'Etudes Spatiales (France), Ministerio de Economía y Competitividad (España), Kavli Institute for Theoretical Physics, Independent Research Fund Denmark, Carlsberg Foundation, Addison, B., Serenelli, Aldo, Themeßl, Nathalie, National Aeronautics and Space Administration (US), National Science Foundation (US), Danish National Research Foundation, National Natural Science Foundation of China, Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, European Commission, Centre National D'Etudes Spatiales (France), Ministerio de Economía y Competitividad (España), Kavli Institute for Theoretical Physics, Independent Research Fund Denmark, Carlsberg Foundation, Addison, B., Serenelli, Aldo, and Themeßl, Nathalie
- Abstract
We report the discovery of a warm sub-Saturn, TOI-257b (HD 19916b), based on data from NASA's Transiting Exoplanet Survey Satellite (TESS). The transit signal was detected by TESS and confirmed to be of planetary origin based on radial velocity observations. An analysis of the TESS photometry, the Minerva-Australis, FEROS, and HARPS radial velocities, and the asteroseismic data of the stellar oscillations reveals that TOI-257b has a mass of MP = 0.138 ± 0.023 M J (43.9 ± 7.3, M⊕), a radius of RP = 0.639 ± 0.013 R J (7.16 ± 0.15, R ⊕), bulk density of 0.65+0.12-0.11 (cgs), and period 18.38818 +0.00085 -0.00084 days. TOI-257b orbits a bright (V = 7.612 mag) somewhat evolved late F-type star with M∗ = 1.390 ± 0.046 rm M sun, R∗ = 1.888 ± 0.033 Rsun, Teff = 6075 ± 90 rm K, and vsin i = 11.3 ± 0.5 km s-1. Additionally, we find hints for a second non-transiting sub-Saturn mass planet on a ∼71 day orbit using the radial velocity data. This system joins the ranks of a small number of exoplanet host stars (∼100) that have been characterized with asteroseismology. Warm sub-Saturns are rare in the known sample of exoplanets, and thus the discovery of TOI-257b is important in the context of future work studying the formation and migration history of similar planetary systems.
- Published
- 2021
49. Going Remote—Demonstration and Evaluation of Remote Technology Delivery and Usability Assessment With Older Adults: Survey Study (Preprint)
- Author
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Jordan R Hill, Addison B Harrington, Philip Adeoye, Noll L Campbell, and Richard J Holden
- Abstract
BACKGROUND The COVID-19 pandemic necessitated “going remote” with the delivery, support, and assessment of a study intervention targeting older adults enrolled in a clinical trial. While remotely delivering and assessing technology is not new, there are few methods available in the literature that are proven to be effective with diverse populations, and none for older adults specifically. Older adults comprise a diverse population, including in terms of their experience with and access to technology, making this a challenging endeavor. OBJECTIVE Our objective was to remotely deliver and conduct usability testing for a mobile health (mHealth) technology intervention for older adult participants enrolled in a clinical trial of the technology. This paper describes the methodology used, its successes, and its limitations. METHODS We developed a conceptual model for remote operations, called the Framework for Agile and Remote Operations (FAR Ops), that combined the general requirements for spaceflight operations with Agile project management processes to quickly respond to this challenge. Using this framework, we iteratively created care packages that differed in their contents based on participant needs and were sent to study participants to deliver the study intervention—a medication management app—and assess its usability. Usability data were collected using the System Usability Scale (SUS) and a novel usability questionnaire developed to collect more in-depth data. RESULTS In the first 6 months of the project, we successfully delivered 21 care packages. We successfully designed and deployed a minimum viable product in less than 6 weeks, generally maintained a 2-week sprint cycle, and achieved a 40% to 50% return rate for both usability assessment instruments. We hypothesize that lack of engagement due to the pandemic and our use of asynchronous communication channels contributed to the return rate of usability assessments being lower than desired. We also provide general recommendations for performing remote usability testing with diverse populations based on the results of our work, including implementing screen sharing capabilities when possible, and determining participant preference for phone or email communications. CONCLUSIONS The FAR Ops model allowed our team to adopt remote operations for our mHealth trial in response to interruptions from the COVID-19 pandemic. This approach can be useful for other research or practice-based projects under similar circumstances or to improve efficiency, cost, effectiveness, and participant diversity in general. In addition to offering a replicable approach, this paper tells the often-untold story of practical challenges faced by mHealth projects and practical strategies used to address them. CLINICALTRIAL ClinicalTrials.gov NCT04121858; https://clinicaltrials.gov/ct2/show/NCT04121858
- Published
- 2020
50. Going Remote-Demonstration and Evaluation of Remote Technology Delivery and Usability Assessment With Older Adults: Survey Study
- Author
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Noll L. Campbell, Jordan R. Hill, Addison B. Harrington, Richard J. Holden, and Philip Adeoye
- Subjects
Technology ,Process management ,mobile usability testing ,020205 medical informatics ,Computer science ,Usability inspection ,Health Informatics ,02 engineering and technology ,Information technology ,usability inspection ,methods ,03 medical and health sciences ,User-Computer Interface ,0302 clinical medicine ,Phone ,Surveys and Questionnaires ,0202 electrical engineering, electronic engineering, information engineering ,Humans ,030212 general & internal medicine ,mHealth ,Minimum viable product ,Aged ,Remote Consultation ,Original Paper ,mobile phone ,business.industry ,System usability scale ,aging ,agile ,COVID-19 ,Usability ,T58.5-58.64 ,Public aspects of medicine ,RA1-1270 ,business ,Agile software development - Abstract
Background The COVID-19 pandemic necessitated “going remote” with the delivery, support, and assessment of a study intervention targeting older adults enrolled in a clinical trial. While remotely delivering and assessing technology is not new, there are few methods available in the literature that are proven to be effective with diverse populations, and none for older adults specifically. Older adults comprise a diverse population, including in terms of their experience with and access to technology, making this a challenging endeavor. Objective Our objective was to remotely deliver and conduct usability testing for a mobile health (mHealth) technology intervention for older adult participants enrolled in a clinical trial of the technology. This paper describes the methodology used, its successes, and its limitations. Methods We developed a conceptual model for remote operations, called the Framework for Agile and Remote Operations (FAR Ops), that combined the general requirements for spaceflight operations with Agile project management processes to quickly respond to this challenge. Using this framework, we iteratively created care packages that differed in their contents based on participant needs and were sent to study participants to deliver the study intervention—a medication management app—and assess its usability. Usability data were collected using the System Usability Scale (SUS) and a novel usability questionnaire developed to collect more in-depth data. Results In the first 6 months of the project, we successfully delivered 21 care packages. We successfully designed and deployed a minimum viable product in less than 6 weeks, generally maintained a 2-week sprint cycle, and achieved a 40% to 50% return rate for both usability assessment instruments. We hypothesize that lack of engagement due to the pandemic and our use of asynchronous communication channels contributed to the return rate of usability assessments being lower than desired. We also provide general recommendations for performing remote usability testing with diverse populations based on the results of our work, including implementing screen sharing capabilities when possible, and determining participant preference for phone or email communications. Conclusions The FAR Ops model allowed our team to adopt remote operations for our mHealth trial in response to interruptions from the COVID-19 pandemic. This approach can be useful for other research or practice-based projects under similar circumstances or to improve efficiency, cost, effectiveness, and participant diversity in general. In addition to offering a replicable approach, this paper tells the often-untold story of practical challenges faced by mHealth projects and practical strategies used to address them. Trial Registration ClinicalTrials.gov NCT04121858; https://clinicaltrials.gov/ct2/show/NCT04121858
- Published
- 2020
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