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Introduction: Delayed onset muscle soreness (DOMS) is associated with temporary morbidity as a result of pain, soreness, and reduced muscular performance that affects the overall performance of the individual. Several interventional modalities have been studied without a conclusive evidence of efficacy. Objective: This study was carried out as part of a continuous attempt to find an effective and quick relief for DOMS. The study investigated the comparative effects of warm-up exercises and infrared radiation in ameliorating the symptoms associated with DOMS. Materials and Methods: Sixty volunteer subjects between the age of 16 years and 35 years had DOMS induced in the left biceps brachii muscle. They were randomized into three groups with 20 subjects in each group. The groups were allocated as follows: Group A as control that received no treatment, Group B had a bout of warm-up exercises consisting of 10 sets of maximal elbow flexion and extension after which DOMS was experimentally induced, and Group C had infrared radiation for 20 min after which DOMS was experimentally induced. Assessment for muscle soreness, pain, and joint range of motion (ROM) was carried out immediately after inducing DOMS and it was repeated 24 h and 48 h later using the Numerical Pain Rating Scale (NPRS), deep palpation (DP), and goniometry, respectively. Results: The infrared group (Group C) had significantly lower scores on NPRS and DP throughout the 3 days compared with the control while the significant effects of warm-up exercises were seen from day 2. There was, however, no significant difference (P > 0.05) in the range of movement (ROM) scores. Compared with warm-up exercises (Group B), infrared resulted in significantly lower NPRS and DP scores and greater ROM only on day 1. Conclusion: Infrared radiation (IRR) is effective in ameliorating the symptoms of DOMS immediately after treatment on day 1 while the effect of warm-up exercises is seen 24 h later. IRR, thus, has a better effect than warm-up exercises in ameliorating the symptoms associated with DOMS.