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In response to climate change, farmers implement various adaptation strategies. This study aimed at investigating the factors that determine adaptation choices using multivariate and ordered econometric models. It also examined the complementarity and substitutability of adaptation strategies using primary data collected from 383 smallholder farmers in North-Western Ethiopia. Our findings revealed adoption complimentary but no evidence of substitutability among adaptation strategies. The multivariate probit model estimation showed that household heads education level, gender, farmland soil fertility, access to extension service, credit access, climate information and key assets ownership are the key determinants of adoptions. The likelihood of adoption decreased when average long-term rainfall increased. In terms of the interaction effect between gender and access to credit, the study found that women-headed households with access to credit were more likely to use a higher number of adaptation strategies relative to women-headed households without access to credit. The significant factors for each strategy were different that entails how important it is to consider their unique characteristics in policy design and interventions. As per the finding, policy makers should consider gender-disaggregated interventions. It is also highly imperative to increase information access, basic education and extension service to boost farmers' adaptation practices. [ABSTRACT FROM AUTHOR]