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7 results on '"Adela Stamati"'

1. Complicațiile obezității la copii și adolescenți

Author

Diana Munteanu, Adela Stamati, Ina Palii, Ninel Revenco, Natalia Uşurelu, and Lorina Vudu

Subjects
Medicine (General), R5-920, Internal medicine, RC31-1245, Other systems of medicine, RZ201-999, Public aspects of medicine, RA1-1270
Abstract

În ultimele decenii, obezitatea constituie cea mai frecventă patologie cronică la copii și adolescenți, afectând fiecare grupă de vârstă. Constituind o tulburare cronică a stării de nutriție, caracterizată prin creșterea greutății corporale pe seama țesutului adipos, obezitatea mai este însoțită de dereglarea verigilor evidente ale metabolismului lipidic, proteic și glucidic și de o serie de comorbidități ca diabet zaharat tip2, riscuri cardiovasculare, insulinoresistența, hepatice și gastrointestinale, complicații neurologice, psiho-sociale, ortopedice, pulmonare, reproductive, hormonale și chiar oncologice. Cei 100 copii participanți în cercetare au fost testați în vederea identifi cării markerilor biochimici, hormonali ce denotă o afectare asociată obezității. Drept rezultat, se constată o netă predominare a suferinței psihologice, valori constant crescute ale tensiunii arteriale, afectarea statutului lipidic, prezența sindromului de apnee în somn. S-a observat prezența diverselor tulburări cauzate de surplusul ponderal la majoritatea copiilor incluși în studiu.

Published
2018

2. Monitoring Methylmalonic Aciduria by NMR Urinomics

Author

Alina Nicolescu, Daniela Blanita, Chiril Boiciuc, Victoria Hlistun, Mihaela Cristea, Dorina Rotaru, Ludmila Pinzari, Ana Oglinda, Adela Stamati, Isabela Tarcomnicu, Andreea Tutulan-Cunita, Danae Stambouli, Sergiu Gladun, Ninel Revenco, Natalia Uşurelu, and Calin Deleanu

Subjects
methylmalonic aciduria, methylmalonic acid, NMR spectroscopy, urine, metabolomics, Organic chemistry, QD241-441
Abstract

The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.

Published
2020
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3. Gaucher disease type 1: the first experience of enzyme replacement therapy in pediatric practice in Moldova - case report

Author

Natalia, Uşurelu, Daniela, Blăniţă, Chiril, Boiciuc, Victoria, Hlistun, Vladimir, Egorov, Eugen, Popovici, Elena, Gnatcova, Adela, Stamati, Ana, Oglindă, Ninel, Revenco, Sergiu, Gladun, and Valentin, Ţurea

Subjects
Articles
Abstract

We report on a case of a little girl patient diagnosed with Gaucher disease (GD) type 1 in her early childhood and our first experience with enzyme replacement therapy (ERT). She was first diagnosed accidentally with enlarged spleen during a pediatric examination when she was three years old, but the family ignored investigations; she was hospitalized for diagnosis at six years old. The GD was confirmed based on: clinical manifestations of left abdominal flank pain, multiple bruising, general weakness, bone pain, low appetite, failure to thrive

Published
2021

5. Monitoring Methylmalonic Aciduria by NMR Urinomics

Author

Ana Oglinda, Dorina Rotaru, Mihaela Cristea, Andreea Tutulan-Cunita, Isabela Tarcomnicu, Adela Stamati, Chiril Boiciuc, Danae Stambouli, Ninel Revenco, Daniela Blanita, Alina Nicolescu, Sergiu Gladun, Natalia Usurelu, Ludmila Pinzari, Victoria Hlistun, and Calin Deleanu

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, Magnetic Resonance Spectroscopy, Time Factors, Methylmalonic acid, Glycine, Pharmaceutical Science, methylmalonic aciduria, Urine, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, NMR spectroscopy, lcsh:Organic chemistry, Drug Discovery, Humans, Physical and Theoretical Chemistry, Child, Amino Acid Metabolism, Inborn Errors, 030304 developmental biology, 0303 health sciences, Chromatography, methylmalonic acid, Chemistry, Organic Chemistry, Infant, Newborn, nutritional and metabolic diseases, Infant, food and beverages, Nuclear magnetic resonance spectroscopy, metabolomics, urine, Methylmalonic aciduria, Chemistry (miscellaneous), Child, Preschool, Creatinine, Molecular Medicine, Female, 030217 neurology & neurosurgery
Abstract

The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time, things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.

Published
2020

7. P330 The clinical course of acute respiratory infections in children with congenital heart diseases

Author

Adela, Stamati, Elena, Papadia, Ina, Palii, and Ninel, Revenco

Abstract

Background and aimsThe World Health Organisation estimates that 1.8 million children under five die of pneumonia each year (WHO, 2014). Children affected by hemodinamically significant congenital heart disease (CHD) experince acute respiratory illness (ARI) and frequency hospitalizations. The aim of our study was to describe the clinical course of ARI in children with various CHD.MethodsIn this retrospective, unicenter, observational study were enrolled all children with ARI and associated CHD, hospitalised in Department of Pulmonology within 1 year (Juanary-Decembry 2016). Protocol study included anamesis, clinical status, aetiology, type of CHD and ARI, laboratory examinations, Rx thoracic, ECG, echocardiography, CT and in same cases.ResultsChildren with CHD had about 0.5% of all hospitalizations. Overall 46 children were enrolled: mean age was 13.5 months (3 months to 10 years), 54.3% were boys, 21 ptc (40.7%) with hemodinamically semnificant CHD; 10 (21.7%) children required intensive care measures and the period of hospitalisation was higher than the average for children without CHD (9.6 versus 7.4 days, p<0.05); more than 70% had varios pneumonies, 16 (35%) children with severe ARI receiving treatment support heart function. The most frequant were CHD with left-to-right shunt: ventricular septal defect (26.1%), atrial sept defect (13%), 5 infants for each atrioventricular canal and permiable ductus arteriosus. 7 children (13.5%) required repeated hospitalizations during the year. ARI aetiology and antibiotic treatment of specific bacterial infection found in sputum the follwoing: 1) Gram-positive bacteria, genus Streptococcusand Staphylococcusin 62.5% cases and, 2) fungal infection Candida albicansin about one half of patients. Simultaneously, sputum analysis has found associated infections in 22 (47.8%) cases. This infections required specific antibacterial and antifungal therapy to prevent infectious cardiac and respiratory complications. Clinical and instrumental evaluation (ECG, ecocardiography) confirmed improving cardiac function following hospital discharge for all the children in our study.ConclusionsInfants with hemodinamically significant CHD have a major risc of ARI, frequent pneumonia (70% of cases). The association of severity of ARI, specific infections and CHD requires multidisciplinary approach to prevent major cardiac and respiratory complications.

Published
2017
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