11 results on '"Aditi Mehta Grewal"'
Search Results
2. Crouzon syndrome and the eye: An overview
- Author
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Kasturi Bhattacharjee, Obaidur Rehman, Vatsalya Venkatraman, Don Kikkawa, Harsha Bhattacharjee, Rahul Gogoi, Aditi Mehta Grewal, and Pragya Bhattacharjee
- Subjects
craniofacial dysmorphism ,craniosynostosis ,crouzon ,exorbitism ,Ophthalmology ,RE1-994 - Abstract
The current literature review aims to evaluate the ocular findings and associated ophthalmic features in Crouzon syndrome. Craniosynostoses are syndromes characterized by premature fusion of sutures of the skull and Crouzon syndrome is the most common of the craniosynostosis syndromes. Early fusion of sutures results in craniofacial anomalies, including abnormalities of the orbits. To prepare this review of the ophthalmic findings in this disorder, an organized search on online databases such as PubMed, Scopus, Cochrane Library, and Ovid was carried out. The key terms searched were “Crouzon”, “craniosynostosis”, “eye” and “ophthalmic”, and 51 research items were found. A total of 17 articles were included after scrutiny of the databases and a further 25 articles were added after augmented search. A detailed review was performed from the final 42 articles. A comprehensive description of associated anomalies is given along with the author's own technique of surgical management in cases with Crouzon syndrome having bilateral luxation bulbi with exposure keratopathy. However, for optimum management of cranial and oculo-facial dysmorphisms, a multidisciplinary team of specialists is required.
- Published
- 2022
- Full Text
- View/download PDF
3. Ophthalmic presentations and long-term outcomes of subconjunctival and atypical orbital myocysticercosis
- Author
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Manpreet Singh, Manjula Sharma, Shweta Chaurasia, Aditi Mehta Grewal, Savleen Kaur, Manpreet Kaur, Deepti Yadav, and Pankaj Gupta
- Subjects
atypical ophthalmic cysticercosis ,atypical orbital myocysticercosis ,orbital myocysticercosis ,subconjunctival cysticercosis ,Ophthalmology ,RE1-994 - Abstract
Purpose: To study the clinical presentation, radiological features, diagnosis, and treatment response in subconjunctival and atypical orbital myocysticercosis. Methods: Retrospective analysis of diagnosed subconjunctival and atypical (strabismus, diplopia, and blepharoptosis) orbital myocysticercosis was performed. A diagnostic criterion (2 of the 3) among clinical features, radiological findings, and treatment response was used in our study. A minimum of “post-treatment” follow-up of 12 months was observed. Results: Thirty-five patients were included with a mean age of 16 years having male predominance (n = 22, 62.8%). All had a unilateral presentation, with 24 (68.6%) patients having subconjunctival cysticercosis, of which 22 were located in close proximity of the rectus muscle insertion. At presentation, 10 patients had diplopia, 7 had strabismus, and 6 had face turn. Pseudo Duane's and pseudo-Brown's syndrome were noted in 5 and 4 patients, respectively. Radiologically, single muscle myositis without scolex was seen in 12 (34.3%) cases. All patients first received medical treatment, and surgical intervention (cyst removal) was attempted after treatment failure. Complete resolution of symptoms was noted in 22 (after medical treatment only) and in 8 (after surgery). Conclusion: In the majority, the subconjunctival cysticercosis is found in proximity to the rectus muscle insertion, as a part of orbital myocysticercosis. In atypical scenarios, a satisfactory response to medical treatment can be considered as diagnostic of cysticercosis.
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- 2021
- Full Text
- View/download PDF
4. Primary chondromyxoid fibroma of the orbit: An orbital mass with calcification
- Author
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Aditi Mehta Grewal, Manpreet Singh, Vikarn Vishwajeet, Umang Thakur, Ashim Das, and Pankaj Gupta
- Subjects
chondromyxoid fibroma ,orbital calcification ,orbitotomy ,primary orbital tumorkey words ,Ophthalmology ,RE1-994 - Abstract
Primary orbital chondromyxoid fibroma is a rarely reported entity. A 34-year-old lady presented with painless, non-axial proptosis of the left eye of 6 months duration. Orbital imaging showed a supero-temporal mass with calcific foci and bone erosion. The mass caused globe compression resulting in choroidal folds. Anterior orbitotomy with complete mass excision was performed. The histopathology revealed a chondromyxoid fibroma. At 12-months follow-up, the patient is doing fine with no clinical recurrence. Chondromyxoid fibroma is an important differential diagnosis for bony orbital tumors.
- Published
- 2019
- Full Text
- View/download PDF
5. Nasal endoscopic features and outcomes of nasal endoscopy guided bicanalicular intubation for complex persistent congenital nasolacrimal duct obstructions
- Author
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Manpreet Singh, Manjula Sharma, Manpreet Kaur, Aditi Mehta Grewal, Deepti Yadav, Sabia Handa, Sonam Yangzes, Zoramthara Zadeng, and Pankaj Gupta
- Subjects
Bicanalicular intubation ,CNLDO ,failed probing ,lacrimal stents ,persistent CNLDO ,Ophthalmology ,RE1-994 - Abstract
Purpose: To study the clinical presentation, nasal endoscopic features, and outcomes of nasal endoscopy guided (NEG) bicanalicular intubation (BCI) in children with complex persistent congenital nasolacrimal duct obstruction (pCNLDO). Methods: A prospective, interventional study including eligible children (age ≤ 12 years) having complex pCNLDO. The demographics, number of previous probings, nasal endoscopy findings, and outcomes; were noted in all children who underwent NEG-BCI with Crawford's stents. Matting of eyelashes (MoE, upper, and lower eyelid), tear-film height (TFH), and fluorescein dye disappearance test (FDDT) was assessed pre and postoperatively. The minimum stent in-situ period was 12 weeks, and the minimum follow-up was 6 months (after stent removal). Results: Total 32 children (36 eyes) including 18 females (56.25%) were studied. At a mean age of 4.9 years, all children had epiphora and discharge with MoE (both upper and lower), raised TFH and positive FDDT. Previously, all children underwent conventional probing (s)- once in 12 (33.3%), twice in 18 (50%) and thrice in 6 (16.7%) eyes. The general ophthalmologists performed the majority (n = 21, 58.33%) of those. The BCI was performed under GA in all eyes, and at a mean follow-up of 8.5 months, the “complete” success was noted in 29 eyes (80.5%), 'partial' success in 4 (11.1%) and failure in 3 (8.3%). The stent prolapse was seen in three. Conclusion: NEG-BCI may provide a satisfactory resolution to complex pCNLDO after single or multiple failed probings. NEG provides confident and efficient management of coexistent intranasal complexities related to the inferior turbinate and meatus.
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- 2019
- Full Text
- View/download PDF
6. Long-term efficacy and safety of imiquimod 5% and fluorouracil 1% creams in medical monotherapy of complex eyelid basal cell carcinomas
- Author
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H. P. Singh, Zoramthara Zadeng, Pankaj Gupta, Aditi Mehta Grewal, Manpreet Singh, Manjula Sharma, and Manpreet Kaur
- Subjects
Skin erythema ,medicine.medical_specialty ,Skin Neoplasms ,Administration, Topical ,Antineoplastic Agents ,Imiquimod ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Depigmentation ,Diabetes mellitus ,medicine ,Humans ,Canthus ,Aged ,Retrospective Studies ,business.industry ,Eyelids ,General Medicine ,medicine.disease ,Dermatology ,Ophthalmology ,Treatment Outcome ,medicine.anatomical_structure ,Carcinoma, Basal Cell ,Fluorouracil ,030220 oncology & carcinogenesis ,Aminoquinolines ,030221 ophthalmology & optometry ,Eyelid ,medicine.symptom ,business ,medicine.drug - Abstract
Purpose: To study the long-term efficacy and safety of local application of imiquimod 5% and fluorouracil 1% creams in complex eyelid basal cell carcinomas (BCCs). Methods: A retrospective, non-comparative study in biopsy-proven, complex (involving canthi or >50% of eyelid length) eyelid BCC patients who were medically unfit for surgical procedures. All patients were medically treated with either of the creams using fixed-dose regimens for a minimum of 3 months. All received oral vitamin C 500 mg QID for 3 months as an adjunct for collagen healing. A minimum of “post-treatment” follow-up of 12 months was observed. Results: Of total 30 patients, imiquimod 5% and fluorouracil 1% were used in 16 and 14 patients, respectively. The mean age of our patients was 70.5 years. The co-morbidities included – severe coronary artery disease using blood-thinners ( n = 19), poorly controlled diabetes ( n = 12), poorly controlled hypertension ( n = 6), on nebulization ( n = 3), and tuberculosis with pulmonary fibrosis ( n = 2). Complete clinical tumor resolution was noted in 10 and 8 patients over 12 and 16.5 weeks, respectively, in imiquimod and fluorouracil groups. Periocular skin erythema, chemical conjunctivitis, and skin depigmentation were seen in all the patients of imiquimod group. On the other hand, the local side-effect profile in fluorouracil patients was limited. Conclusion: The medical treatment of complex eyelid BCC is a useful alternative to surgery in the elderly with significant co-morbidities. It provides a promising long-term relief with a tolerable side-effect profile. A prospective, randomized, double-blinded trial would provide stronger evidence for the efficacy of these drugs.
- Published
- 2021
7. Ophthalmic features and management outcomes of 30 children having Goldenhar syndrome
- Author
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Manpreet Singh, Pankaj Gupta, Aditi Mehta Grewal, Deepti Yadav, Zoramthara Zadeng, Manpreet Kaur, and Sonam Yangzes
- Subjects
Male ,Upper eyelid coloboma ,medicine.medical_specialty ,Visual acuity ,Eye Movements ,Lipodermoid ,Goldenhar syndrome ,Ophthalmologic Surgical Procedures ,Scoliosis ,03 medical and health sciences ,Goldenhar Syndrome ,0302 clinical medicine ,medicine ,Humans ,Eyelid coloboma ,Retrospective Studies ,business.industry ,Infant, Newborn ,Disease Management ,Eyelids ,Infant ,medicine.disease ,eye diseases ,Surgery ,Ophthalmology ,Treatment Outcome ,medicine.anatomical_structure ,Child, Preschool ,Orthopedic surgery ,030221 ophthalmology & optometry ,Female ,sense organs ,Eyelid ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
To study the ophthalmic clinical profile and the management outcomes of children having Goldenhar syndrome (GS). Retrospective review of included children fulfilling the diagnostic criteria of GS was performed. The demography, ophthalmic features, systemic anomalies, and treatment outcomes were recorded manually from patient files. An ENT, pediatrics, cardiology, and orthopedics consultation was sought for all GS patients before taking up for any ophthalmic surgical procedure. The anatomical (ocular surface and eyelid) and functional {vision and extraocular movements (EOM)} factors were exclusively studied. We ensured a minimum postoperative follow-up of 12 months, and our data were compared with the major studies featuring ‘ophthalmic features’ of GS. Totally 30 children (females = 18, 60%) were included with a median presenting age of 48 months. Twenty-seven (90%) had unilateral ophthalmic involvement with major features being upper eyelid coloboma (n = 25, 75.76%), lipodermoid (n = 18, 54.55%), and limbal dermoid (n = 10, 30.3%). Diminution of visual acuity was recorded in 22 (73.3%), while five (16.7%) had limitation of EOM. Systemically, the prominent features included hemifacial hypotrophy (100%), auricular anomalies (80%), cardiac anomalies (10%), and scoliosis (6.67%). The eyelid colobomas were repaired with the direct closure ± cantholysis technique or using a Tenzel’s flap. All children had satisfactory anatomical and functional outcomes after ophthalmic surgical interventions without any significant complications. The tailored ophthalmic surgical intervention(s) provides satisfactory restoration of anatomy and functionality of the eye. These children need specific multi-discipline consultations for the holistic management and complete care.
- Published
- 2019
8. Long-term ophthalmic anatomical and functional outcomes after surgical removal of intraorbital foreign bodies
- Author
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Deepti Yadav, Jyoti Singh, Pankaj Gupta, Manjula Sharma, Zoramthara Zadeng, Aditi Mehta Grewal, Manpreet Kaur, and Manpreet Singh
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Eye Movements ,Visual Acuity ,Ophthalmologic Surgical Procedures ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,Ocular Motility Disorders ,0302 clinical medicine ,Surgical removal ,medicine ,Retrospective analysis ,Exophthalmos ,Humans ,Orbital foreign body ,Child ,Foreign Bodies ,Retrospective Studies ,business.industry ,Medical record ,General Medicine ,Prognosis ,Eye Injuries, Penetrating ,Term (time) ,Surgery ,Ophthalmology ,Eye Foreign Bodies ,Child, Preschool ,030221 ophthalmology & optometry ,Female ,Tomography, X-Ray Computed ,business ,Orbit ,Follow-Up Studies - Abstract
Purpose: To analyze the anatomical and functional ophthalmic parameters after the surgical removal of various intraorbital foreign bodies. Methods: A retrospective analysis of medical records was performed featuring detailed history, ophthalmic examination, orbital computed tomographic scans, treatment details, and outcomes. The analyzed anatomical factors included extraocular movements, the position of the eyeball (proptosis, dystopia, and enophthalmos), and fullness of orbital sulci. The functional assessment was based on visual acuity, pupillary reactions, and diplopia. The outcomes were defined as complete, partial, and failure after a minimum follow-up of 1 year. Results: Of 32 patients, the organic and inorganic intraorbital foreign bodies were surgically removed from 18 (56.25%) and 14 (43.75%) orbits, respectively. At presentation, anatomically the extraocular movement restriction, proptosis/dystopia/enophthalmos, and orbital sulcus fullness were noted in 26 (81.25%), 24 (75%), and 15 (46.88%), respectively. Functionally, diminished visual acuity, diplopia, and pupil abnormalities were seen in 27 (84.38%), 14 (43.75%), and 8 (25%), respectively. After intraorbital foreign body removal at a mean follow-up of 14 months, the improvement of anatomical factors (same sequence) were observed in 8 (30.77%), 20 (83.33%), and 12 (80%), respectively. In functional factors (same sequence), the improvement was noted in none (0%), 13 (92.86%), and 5 (62.5%), respectively. Hence, the majority of patients (n = 20, 62.5%) achieved partial success, while 8 (25%) had complete success. Four (12.5%) had treatment failure despite similar management protocols. Conclusion: The anatomical outcomes are better than the functional outcomes after surgical removal of the intraorbital foreign bodies. The visual acuity does not improve considerably after the surgical removal of intraorbital foreign bodies. Overall, the wooden intraorbital foreign bodies have poorer anatomical and functional prognosis.
- Published
- 2019
9. Refractive Surgery: Basics of Laser Consoles and Ablation Profiles
- Author
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Aditi Mehta Grewal, Anchal Thakur, Amit Gupta, Chintan Malhotra, and Sartaj Singh Grewal
- Subjects
medicine.medical_specialty ,Materials science ,Excimer laser ,medicine.medical_treatment ,Ophthalmology ,Refractive surgery ,medicine ,LASIK ,Small incision lenticule extraction ,Photoablation ,Keratomileusis ,Ablation ,Photorefractive keratectomy - Abstract
Refractive procedures may be performed on the cornea or intraocularly. Laser-based corneal procedures broadly include photorefractive keratectomy (PRK), laser-assisted in situ keratomileusis (LASIK), refractive lenticule extraction (ReLEx), and small incision lenticule extraction (SMILE). While PRK and LASIK rely on excimer laser photoablation, ReLEx and SMILE are based on the photodisruptive femtosecond laser.
- Published
- 2019
10. Ophthalmic presentations and long-term outcomes of subconjunctival and atypical orbital myocysticercosis
- Author
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Shweta Chaurasia, Savleen Kaur, Manjula Sharma, Deepti Yadav, Manpreet Singh, Pankaj Gupta, Manpreet Kaur, and Aditi Mehta Grewal
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,genetic structures ,Atypical ophthalmic cysticercosis ,atypical orbital myocysticercosis ,Orbital Diseases ,Long term outcomes ,Humans ,Medicine ,Cyst ,Eye Infections, Parasitic ,Strabismus ,Myositis ,Retrospective Studies ,Diplopia ,Cysticercosis ,business.industry ,orbital myocysticercosis ,RE1-994 ,medicine.disease ,eye diseases ,Surgery ,Ophthalmology ,Oculomotor Muscles ,Radiological weapon ,subconjunctival cysticercosis ,medicine.symptom ,Presentation (obstetrics) ,Special Focus, Ophthalmic Plastic Surgery, Original Article ,Tomography, X-Ray Computed ,business - Abstract
Purpose: To study the clinical presentation, radiological features, diagnosis, and treatment response in subconjunctival and atypical orbital myocysticercosis. Methods: Retrospective analysis of diagnosed subconjunctival and atypical (strabismus, diplopia, and blepharoptosis) orbital myocysticercosis was performed. A diagnostic criterion (2 of the 3) among clinical features, radiological findings, and treatment response was used in our study. A minimum of “post-treatment” follow-up of 12 months was observed. Results: Thirty-five patients were included with a mean age of 16 years having male predominance (n = 22, 62.8%). All had a unilateral presentation, with 24 (68.6%) patients having subconjunctival cysticercosis, of which 22 were located in close proximity of the rectus muscle insertion. At presentation, 10 patients had diplopia, 7 had strabismus, and 6 had face turn. Pseudo Duane's and pseudo-Brown's syndrome were noted in 5 and 4 patients, respectively. Radiologically, single muscle myositis without scolex was seen in 12 (34.3%) cases. All patients first received medical treatment, and surgical intervention (cyst removal) was attempted after treatment failure. Complete resolution of symptoms was noted in 22 (after medical treatment only) and in 8 (after surgery). Conclusion: In the majority, the subconjunctival cysticercosis is found in proximity to the rectus muscle insertion, as a part of orbital myocysticercosis. In atypical scenarios, a satisfactory response to medical treatment can be considered as diagnostic of cysticercosis.
- Published
- 2021
11. Primary chondromyxoid fibroma of the orbit: An orbital mass with calcification
- Author
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Manpreet Singh, Umang Thakur, Vikarn Vishwajeet, Pankaj Gupta, Ashim Das, and Aditi Mehta Grewal
- Subjects
Adult ,medicine.medical_specialty ,genetic structures ,Case Reports ,Fibroma ,Ophthalmologic Surgical Procedures ,Mass excision ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Orbital mass ,medicine ,Humans ,primary orbital tumorkey words ,business.industry ,orbitotomy ,orbital calcification ,Chondromyxoid fibroma ,Calcinosis ,medicine.disease ,eye diseases ,body regions ,stomatognathic diseases ,Ophthalmology ,medicine.anatomical_structure ,lcsh:RE1-994 ,Clinical recurrence ,030221 ophthalmology & optometry ,Orbital Neoplasms ,Female ,Histopathology ,sense organs ,Radiology ,Differential diagnosis ,Tomography, X-Ray Computed ,business ,Chondroma ,030217 neurology & neurosurgery ,chondromyxoid fibroma ,Orbit (anatomy) ,Calcification - Abstract
Primary orbital chondromyxoid fibroma is a rarely reported entity. A 34-year-old lady presented with painless, non-axial proptosis of the left eye of 6 months duration. Orbital imaging showed a supero-temporal mass with calcific foci and bone erosion. The mass caused globe compression resulting in choroidal folds. Anterior orbitotomy with complete mass excision was performed. The histopathology revealed a chondromyxoid fibroma. At 12-months follow-up, the patient is doing fine with no clinical recurrence. Chondromyxoid fibroma is an important differential diagnosis for bony orbital tumors.
- Published
- 2019
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