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4. Piezo1 in pulmonary arterial smooth muscle cells – A critical player for the development of pulmonary hypertension

Author

Abid, S., primary, Houssaini, A., additional, Knoepp, F., additional, Born, E., additional, Marcos, E., additional, Lipskaia, L., additional, Arhatte, M., additional, Glogowska, E., additional, Vienney, N., additional, Kraut, S., additional, Quanz, K., additional, Fenner-Nau, D., additional, Weissmann, N., additional, Honoré, E., additional, and Adnot, S., additional

Published
2024
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19. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice

Author

Izikki, M., Hanoun, N., Marcos, E., Savale, L., Barlier-Mur, A.M., Saurini, F., Eddahibi, S., Hamon, M., and Adnot, S.

Subjects
Tryptophan -- Influence, Tryptophan -- Properties, Morphological variation -- Evaluation, Pulmonary hypertension -- Physiological aspects, Vascular smooth muscle -- Properties, Genetically modified mice -- Physiological aspects, Biological sciences
Abstract

Serotonin [5-hydroxytryptamine (5-HT)] biosynthesis depends on two rate-limiting tryptophan hydroxylases (Tph): Tph1, which is expressed in peripheral organs, and Tph2, which is expressed in neurons. Because 5-HT is involved in pulmonary hypertension (PH), we investigated whether genetic variations in Tph1 and/or Tph2 affected PH development in mice. To examine the functional impact of peripheral Tph1 deficiency on hypoxic PH, we used [Tph1.sup.-/-] mice characterized by very low 5-HT synthesis rates and contents in the gut and lung and increased 5-HT synthesis in the forebrain. With chronic hypoxia, 5-HT synthesis in the forebrain increased further. Hypoxic PH, right ventricular hypertrophy, and distal pulmonary artery muscularization were less severe (P < 0.001) than in wild-type controls. The Tph inhibitor p-chlorophenylalanine (100 mg x [kg.sup.-1] x [day.sup.-1]) further improved these parameters. We then investigated whether mouse strains harboring the C1473G polymorphism of the Tph2 gene showed different PH phenotypes during hypoxia. Forebrain Tph activity was greater and hypoxic PH was more severe in C57B1/6 and 129X1/SvJ mice homozygous for the 1473C allele than in DBA/2 and BALB/cJ mice homozygous for the 1473G allele, p-Chlorophenylalanine reduced PH in all groups and abolished the difference in PH severity across mouse strains. Hypoxia increased 5-hydroxytryptophan accumulation but decreased 5-HT contents in the forebrain and lung, suggesting accelerated 5-HT turnover during hypoxia. These results provide evidence that dysregulation of 5-HT synthesis is closely linked to the hypoxic PH phenotype in mice and that Tph1 and Tph2 may contribute to PH development. vascular smooth muscle; transgenic mice

Published
2007

22. Clearance P16Ink4a Positive Cells Regenerate Normal Lungs After Early Life Injury

Author

Zysman, M., primary, Ribeiro Baptista, B., additional, Essari, L.-A., additional, Thibault de Ménonville, C., additional, Giffard, C., additional, Franco-montoya, M.-L., additional, Breau, M., additional, Souktani, R., additional, tran-van-nhieu, J., additional, Rottier, R., additional, Adnot, S., additional, Epaud, R., additional, Chabot, J.F., additional, Lanone, S., additional, Boczkowski, J., additional, and Boyer, L., additional

Published
2020
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31. Chronic Antioxidant NAcetylcysteine Treatment Induces Lung Cancer Formation in Mice

Author

Breau, M., primary, Houssaini, A., additional, Lipskaia, L., additional, Pallazo, A., additional, Collin, G., additional, Czibik, G., additional, Abid, S., additional, Born, E., additional, Marcos, E., additional, Attwe, A., additional, Beaulieu, D., additional, Bourachot, B., additional, Bernard, D., additional, Mechta-Grigoriou, F., additional, and Adnot, S., additional

Published
2019
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33. CCR2- and CCR5-Mediated Crosstalk Between Macrophages and Pulmonary-Artery Smooth Muscle Cells Drives Pulmonary Hypertension

Author

Abid, S., primary, Marcos, E., additional, Parpaleix, A., additional, Amsellem, V., additional, Breau, M., additional, Houssaini, A., additional, Vienney, N., additional, Validire, P., additional, Lefevre, M., additional, Derumeaux, G., additional, Evans, S.M., additional, Hubeau, C., additional, Delcroix, M., additional, Quarck, R., additional, Adnot, S., additional, and Lipskaia, L., additional

Published
2019
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34. Consequence of Desmin gene mutation on development of chronic hypoxic pulmonary hypertension in mice

Author

Abid, S., primary, Houssaini, A., additional, Born, E., additional, Ternacle, J., additional, Hovhannisyan, Y., additional, Beaulieu, D., additional, Marcos, E., additional, Li, Z., additional, Marthan, R., additional, Agbulut, O., additional, Derumeaux, G., additional, Adnot, S., additional, Guibert, C., additional, and Lipskaia, L., additional

Published
2019
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42. SFSPM 2018 — Congrès de la Société Française de Sénologie et de Pathologie Mammaire (Avignon, 7-9/11-2018)

Author

Serin, D., primary, Adnot, S., additional, Allioux, C., additional, Alran, S., additional, Bazin, B., additional, Bendiane, M.-K., additional, Bo-Gallon, E., additional, Boinon, D., additional, Bouhnik, A.-D., additional, Bourstyn, E., additional, Charles, C., additional, Clément, A., additional, Coussirou, J., additional, Cutuli, B., additional, Dauchy, S., additional, Debourdeau, P., additional, Degos, L., additional, Duponchel, P., additional, Durand, T., additional, Eisinger, F., additional, Falandry, C., additional, Favier, B., additional, Heudel, P.E., additional, Ledig, C., additional, Lesur, A., additional, Mancini, J., additional, Monet, A., additional, Moretta, J., additional, Neveu, J., additional, Ninot, G., additional, Préau, M., additional, Ravot, C., additional, Rousset-Jablonski, C., additional, Touzani, R., additional, Valéro, M., additional, and Zambrowski, J.-J., additional

Published
2018
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43. Exercise rescues obesity-induced adipose tissue premature aging and restores cardio-metabolic homeostasis

Author

Pini, M., primary, Czibik, G., additional, Sawaki, D., additional, Mercedes, R., additional, Ternacle, J., additional, Henegar, C., additional, Braud, L., additional, Mezdari, Z., additional, Radu, C., additional, Dubois-Randé, J.L., additional, Adnot, S., additional, Foresti, R., additional, Motterlini, R., additional, and Derumeaux, G., additional

Published
2018
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45. Role for Telomerase in Pulmonary Hypertension

Author

Mouraret, N., Houssaini, A., Abid, S., Quarck, R., Marcos, E., Parpaleix, A., Gary-Bobo, G., Dubois-Rande, J.-L., Derumeaux, G., Boczkowski, J., Delcroix, M., Blasco, M. A., Lipskaia, L., Amsellem, V., and Adnot, S.

Abstract

Cells exhibiting dysregulated growth may express telomerase reverse transcriptase (TERT), whose dual function consists in maintaining telomere length, in association with the RNA template molecule TERC and controlling cell growth. Here, we investigated lung TERT in human and experimental pulmonary hypertension (PH) and its role in controlling pulmonary artery-smooth muscle cell (PA-SMC) proliferation. ispartof: Circulation vol:131 issue:8 pages:742-55 ispartof: location:United States status: published

Published
2015

47. Regulation of immunoproteasome function in the lung

Author

Keller, I.E., Vosyka, O., Takenaka, S., Kloss, A., Dahlmann, B., Willems, L.I., Verdoes, M., Overkleeft, H.S., Marcos, E., Adnot, S., Hauck, S.M., Ruppert, C., Gunther, A., Herold, S., Ohno, S., Adler, H., Eickelberg, O., Meiners, S., Keller, I.E., Vosyka, O., Takenaka, S., Kloss, A., Dahlmann, B., Willems, L.I., Verdoes, M., Overkleeft, H.S., Marcos, E., Adnot, S., Hauck, S.M., Ruppert, C., Gunther, A., Herold, S., Ohno, S., Adler, H., Eickelberg, O., and Meiners, S.

Abstract

Contains fulltext : 152662.pdf (publisher's version ) (Open Access), Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8(+) T cells that are activated by MHC I-mediated presentation of pathogen-derived antigenic peptides. The immunoproteasome, a specialized form of the proteasome, improves generation of antigenic peptides for MHC I presentation thereby facilitating anti-viral immune responses. However, immunoproteasome function in the lung has not been investigated in detail yet. In this study, we comprehensively characterized the function of immunoproteasomes in the human and murine lung. Parenchymal cells of the lung express low constitutive levels of immunoproteasomes, while they are highly and specifically expressed in alveolar macrophages. Immunoproteasome expression is not altered in whole lung tissue of COPD patients. Novel activity-based probes and native gel analysis revealed that immunoproteasome activities are specifically and rapidly induced by IFNgamma treatment in respiratory cells in vitro and by virus infection of the lung in mice. Our results suggest that the lung is potentially capable of mounting an immunoproteasome-mediated efficient adaptive immune response to intracellular infections.

Published
2015

48. Genetic Basis of Pulmonary Arterial Hypertension Current Understanding and Future Directions

Author

NEWMAN J. H., TREMBATH R. C., MORSE J. A., GRUNIG E., LOYD J. E., ADNOT S., COCCOLO F., PHILLIPS III J. A., KNOWLES J. A., JANSSEN B., EICKELBERG O., EDDAHIBI S., HERVE P., NICHOLS W. C., ELLIOTT G., VENTURA, CARLO, NEWMAN J.H., TREMBATH R.C., MORSE J.A., GRUNIG E., LOYD J.E., ADNOT S., COCCOLO F., VENTURA C., PHILLIPS III J.A., KNOWLES J.A., JANSSEN B., EICKELBERG O., EDDAHIBI S., HERVE P., NICHOLS W.C., and ELLIOTT G.

Published
2004

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