Search

Your search keyword '"Adorni, M"' showing total 192 results
Start Over Author "Adorni, M"
192 results on '"Adorni, M"'

2. A systematic approach for the adequacy analysis of a set of experimental databases: Application in the framework of the ATRIUM activity

Author

Baccou, J., Glantz, T., Ghione, A., Sargentini, L., Fillion, P., Damblin, G., Sueur, R., Iooss, B., Fang, J., Liu, J., Yang, C., Zheng, Y., Ui, A., Saito, M., Mendizábal Sanz, R., Bersano, A., Mascari, F., Skorek, T., Tiborcz, L., Hirose, Y., Takeda, T., Nakamura, H., Choi, C., Heo, J., Petruzzi, A., Zeng, K., Xie, Z., Wu, X., Eguchi, H., Pangukir, F., Breijder, P., Franssen, S., Perret, G., Clifford, I.D., Coscia, T.M., Di Maio, F., Zio, E., Pedroni, N., Zhang, J., Freixa, J., Rizzo, F., Ciurluini, C., Giannetti, F., and Adorni, M.

Published
2024
Full Text
View/download PDF

4. Current status of MELCOR 2.2 for fusion safety analyses

Author

Mascari, F., Bersano, A., Adorni, M., D'Ovidio, G., Martín-Fuertes, F., Jin, X.Z., Mazzini, G., Gonfiotti, B., Georgiev, G., Leskovar, M., Bertani, C., Testoni, R., Giannetti, F., D'Onorio, M., Agnello, G., Di Maio, P.A., Angelucci, M., Paci, S., Grippo, G., Fernández-Cosials, K., Dongiovanni, D., and Malicki, M.

Published
2023
Full Text
View/download PDF

7. List of contributors

Author

Adorni, M., primary, Bals, Christine, additional, Beck, Sara, additional, Bernaud, S., additional, Boulore, A., additional, Chauvin, N., additional, Cheng, Hui, additional, Dailey, Ryan, additional, Del Nevo, A., additional, Dong, Xiaomeng, additional, Duan, Guangtao, additional, Dumas, J.C., additional, Duncan, A., additional, Feng, Tangtao, additional, Gui, Miao, additional, Gurgen, Anil, additional, Helfer, T., additional, Hollands, Thorsten, additional, Introini, C., additional, Koshizuka, Seiichi, additional, Lainet, M., additional, Li, Xin, additional, Lin, Lianshan, additional, Lovasz, Liviusz, additional, Luzzi, L., additional, Magni, A., additional, Marelle, V., additional, Masson, R., additional, Michel, B., additional, Mondry, Kaya G., additional, Ni, Xinghe, additional, Noirot, L., additional, Nowack, Holger, additional, Pellegrini, Marco, additional, Perez, Alejandro, additional, Qiu, Bowen, additional, Ramière, I., additional, Rozzia, D., additional, Saito, Shimpei, additional, Schaffrath, Andreas, additional, Schubert, A., additional, Sercombe, J., additional, Sonnenkalb, Martin, additional, Spengler, Claus, additional, Su, Guanghui, additional, Sun, Lin, additional, Sun, Z.J., additional, Van Uffelen, P., additional, Vayssier, George, additional, Viallard, I., additional, Wang, Jun, additional, Wang, Xing, additional, Wang, Zidi, additional, Wielenberg, Andreas, additional, Xi, Jianqi, additional, Yamaji, Akifumi, additional, Yu, Jiankai, additional, Zhang, Fan, additional, Zhang, Jing, additional, Zhang, Luteng, additional, Zhang, Tengfei, additional, Zhao, Xingang, additional, Zhong, Xianping, additional, and Zhou, Yukun, additional

Published
2021
Full Text
View/download PDF

8. Neoadjuvant chemotherapy followed by radical surgery in locally advanced vulvar carcinoma: a single-institution experience

Author

Adorni, M, Bazzurini, L, Lissoni, A, Vecchione, F, Negri, S, Grassi, T, Buda, A, Landoni, F, Adorni M., Bazzurini L., Lissoni A. A., Vecchione F., Negri S., Grassi T., Buda A., Landoni F., Adorni, M, Bazzurini, L, Lissoni, A, Vecchione, F, Negri, S, Grassi, T, Buda, A, Landoni, F, Adorni M., Bazzurini L., Lissoni A. A., Vecchione F., Negri S., Grassi T., Buda A., and Landoni F.

Abstract

Background: Squamous cell carcinoma of the vulva is a rare malignancy that affects elderly women. About one-third of vulvar cancers are diagnosed in an advanced stage, requiring extensive surgery. Neoadjuvant chemotherapy (NACT) has been introduced to reduce local tumor burden. In this retrospective study, we analyze the efficacy and toxicity of NACT followed by radical surgery. Methods: Patients with locally advanced vulvar cancer (LAVC) treated at our institution with neoadjuvant platinum and paclitaxel-based chemotherapy ± ifosfamide followed by surgery at our institution were retrospectively identified. Results: Fourteen patients (93%) completed NACT with tolerable toxicities (G3–G4 toxicity: 30%). Thirteen patients (87%) underwent surgery. The overall clinical response rate on vulvar disease was 66% (20% complete response, 46% partial response), confirmed by histopathologic analysis, while on inguinal lymph nodes it was 69% (23% complete response, 46% partial response). At the pathologic examination, all patients had negative surgical margins. Three out of 9 patients (33%) with lesions infiltrating the urethral meatus and 4 patients out of 7 (57%) with anal involvement did not require urethral amputation or colostomy, respectively, after NACT. No severe postoperative complications were described. Overall survival at 5 years was 60%, and median overall survival was 76 months. Conclusion: NACT followed by surgery in locally advanced vulvar cancer is well tolerated and allows surgical modulation.

Published
2022

9. Advanced low grade serous ovarian cancer: A retrospective analysis of surgical and chemotherapeutic management in two high volume oncological centers

Author

Di Lorenzo, P, Conteduca, V, Scarpi, E, Adorni, M, Multinu, F, Garbi, A, Betella, I, Grassi, T, Bianchi, T, Di Martino, G, Amadori, A, Maniglio, P, Strada, I, Carinelli, S, Jaconi, M, Aletti, G, Zanagnolo, V, Maggioni, A, Savelli, L, De Giorgi, U, Landoni, F, Colombo, N, Fruscio, R, Di Lorenzo P., Conteduca V., Scarpi E., Adorni M., Multinu F., Garbi A., Betella I., Grassi T., Bianchi T., Di Martino G., Amadori A., Maniglio P., Strada I., Carinelli S., Jaconi M., Aletti G., Zanagnolo V., Maggioni A., Savelli L., De Giorgi U., Landoni F., Colombo N., Fruscio R., Di Lorenzo, P, Conteduca, V, Scarpi, E, Adorni, M, Multinu, F, Garbi, A, Betella, I, Grassi, T, Bianchi, T, Di Martino, G, Amadori, A, Maniglio, P, Strada, I, Carinelli, S, Jaconi, M, Aletti, G, Zanagnolo, V, Maggioni, A, Savelli, L, De Giorgi, U, Landoni, F, Colombo, N, Fruscio, R, Di Lorenzo P., Conteduca V., Scarpi E., Adorni M., Multinu F., Garbi A., Betella I., Grassi T., Bianchi T., Di Martino G., Amadori A., Maniglio P., Strada I., Carinelli S., Jaconi M., Aletti G., Zanagnolo V., Maggioni A., Savelli L., De Giorgi U., Landoni F., Colombo N., and Fruscio R.

Abstract

Background: Low-grade serous ovarian cancer (LGSOC) is a rare entity with different behavior compared to high-grade serous (HGSOC). Because of its general low chemosensitivity, complete cytoreductive surgery with no residual disease is crucial in advanced stage LGSOC. We evaluated the impact of optimal cytoreduction on survival outcome both at first diagnosis and at recurrence. Methods: We retrospectively studied consecutive patients diagnosed with advanced LGSOCs who underwent cytoreductive surgery in two oncological centers from January 1994 to December 2018. Survival curves were estimated by the Kaplan–Meier method, and 95% confidence intervals (95% CI) were estimated using the Greenwood formula. Results: A total of 92 patients were included (median age was 47 years, IQR 35–64). The median overall survival (OS) was 142.3 months in patients with no residual disease (RD), 86.4 months for RD 1–10 mm and 35.2 months for RD >10 mm (p = 0.002). Progression-free survival (PFS) was inversely related to RD after primary cytoreductive surgery (RD = 0 vs RD = 1–10 mm vs RD >10 mm, p = 0.002). On multivariate analysis, RD 1–10 mm (HR = 2.30, 95% CI 1.30–4.06, p = 0.004), RD >10 mm (HR = 3.89, 95% CI 1.92–7.88, p = 0.0004), FIGO stage IV (p = 0.001), and neoadjuvant chemotherapy (NACT) (p = 0.010) were independent predictors of PFS. RD >10 mm (HR = 3.13, 95% CI 1.52–6.46, p = 0.004), FIGO stage IV (p <0.0001) and NACT (p = 0.030) were significantly associated with a lower OS. Conclusions: Optimal cytoreductive surgery improves survival outcomes in advanced stage LGSOCs. When complete debulking is impossible, a RD <10 mm confers better OS compared to an RD >10 mm in this setting of patients.

Published
2022

10. Richer, greener, and more thermophilous?–a first overview of global warming induced changes in the Italian alpine plant communities within the new GLORIA ITALIA NETWORK

Author

Porro, F, Orsenigo, S, Abeli, T, Mondoni, A, Corli, A, White, F, Lodetti, S, Tomaselli, M, Petraglia, A, Carbognani, M, Gualmini, M, Forte, T, Erschbamer, B, Nicklas, L, Carnicero, P, Mallaun, M, Unterluggauer, P, Stanisci, A, Giancola, C, di Martino, L, Barni, E, Oddi, L, Morra di Cella, U, Gentili, R, Dellavedova, R, Adorni, M, Pauli, H, Rossi, G, Porro F., Orsenigo S., Abeli T., Mondoni A., Corli A., White F. J., Lodetti S., Tomaselli M., Petraglia A., Carbognani M., Gualmini M., Forte T. G. W., Erschbamer B., Nicklas L., Carnicero P., Mallaun M., Unterluggauer P., Stanisci A., Giancola C., di Martino L., Barni E., Oddi L., Morra di Cella U., Gentili R., Dellavedova R., Adorni M., Pauli H., Rossi G., Porro, F, Orsenigo, S, Abeli, T, Mondoni, A, Corli, A, White, F, Lodetti, S, Tomaselli, M, Petraglia, A, Carbognani, M, Gualmini, M, Forte, T, Erschbamer, B, Nicklas, L, Carnicero, P, Mallaun, M, Unterluggauer, P, Stanisci, A, Giancola, C, di Martino, L, Barni, E, Oddi, L, Morra di Cella, U, Gentili, R, Dellavedova, R, Adorni, M, Pauli, H, Rossi, G, Porro F., Orsenigo S., Abeli T., Mondoni A., Corli A., White F. J., Lodetti S., Tomaselli M., Petraglia A., Carbognani M., Gualmini M., Forte T. G. W., Erschbamer B., Nicklas L., Carnicero P., Mallaun M., Unterluggauer P., Stanisci A., Giancola C., di Martino L., Barni E., Oddi L., Morra di Cella U., Gentili R., Dellavedova R., Adorni M., Pauli H., and Rossi G.

Abstract

We announce the formation of the “GLORIA ITALIA NETWORK” and present an overview of the Italian alpine plant communities changes that have occurred in the last 20 years. This network will provide coordination between Italian GLORIA sites and enhance public awareness of changes in alpine plant diversity under climate change.

Published
2022

11. Nuclear Fuel Modelling During Power Ramp

Author

Cantini, F., Adorni, M., and D'Auria, FRANCESCO SAVERIO

Subjects
Energy (miscellaneous)
Abstract

Fuel rods operating for several years in a LWR can experience fuel-cladding gap closure as a result of the phenomena due to temperature and irradiation. Local power increase induces circumferential stresses in the cladding as a result of the different expansion in the cladding and the pellet. In presence of corrosive fission products (i.e. Iodine) and beyond specific stress threshold and level of burnup, cracks may grow-up from the internal to the external cladding surface, causing fuel rod failure. The phenomenon, known as pellet cladding interaction-stress corrosion cracking PCI/SCC, or PCI, has been identified as a problem since the 70's. The PWR Super-Ramp experiment (part of OECD/NEA “International Fuel Performance Experiments (IFPE) database”) twenty eight fuel rods behaviour has been simulated using TRANSURANUS code version “v1m1j11”. Two sets (“Reference” and “Improved”) of suitable input decks modelling the fuel rods, based on the available literature are used to run the simulations. Focus is given to the main phenomena which are involved or may influence the cladding failure. Systematic comparison of the code results with the experimental data are performed for the parameters relevant for the PCI phenomenon. Sensitivity calculations on fission gas release models implemented in TRANSURANUS code are also performed in order to address the impact on the results. The results show the ability of TRANSURANUS version “v1m1j11” in conservatively predicting the rods failure due to PCI in PWR fuel and Zircaloy-4 cladding. Increased availability of experimental data would help to perform a deeper analysis.

Published
2022

14. Advanced low grade serous ovarian cancer: A retrospective analysis of surgical and chemotherapeutic management in two high volume oncological centers

Author

Di Lorenzo P., Conteduca V., Scarpi E., Adorni M., Multinu F., Garbi A., Betella I., Grassi T., Bianchi T., Di Martino G., Amadori A., Maniglio P., Strada I., Carinelli S., Jaconi M., Aletti G., Zanagnolo V., Maggioni A., Savelli L., De Giorgi U., Landoni F., Colombo N., Fruscio R., Di Lorenzo, P, Conteduca, V, Scarpi, E, Adorni, M, Multinu, F, Garbi, A, Betella, I, Grassi, T, Bianchi, T, Di Martino, G, Amadori, A, Maniglio, P, Strada, I, Carinelli, S, Jaconi, M, Aletti, G, Zanagnolo, V, Maggioni, A, Savelli, L, De Giorgi, U, Landoni, F, Colombo, N, and Fruscio, R

Subjects
low-grade serous ovarian cancer, Cancer Research, Oncology, primary cytoreduction, adjuvant treatment, residual disease, secondary cytoreductive surgery, neoadjuvant chemotherapy
Abstract

Simple summaryLow-grade serous ovarian cancer (LGSOC) represents an uncommon histotype of serous ovarian cancer (accounting for approximately 5% of all ovarian cancer) with a distinct behavior compared to its high-grade serous counterpart, characterized by a better prognosis and low response rate to chemotherapeutic agents. Similar to high-grade serous ovarian cancer, cytoreductive surgery is considered crucial for patient survival. This retrospective study aimed to analyze the outcomes of women affected by advanced stages (III–IV FIGO) of LGSOC from two high-volume oncological centers for ovarian neoplasm. In particular, we sought to evaluate the impact on survival outcomes of optimal cytoreductive surgery [i.e., residual disease (RD) BackgroundLow-grade serous ovarian cancer (LGSOC) is a rare entity with different behavior compared to high-grade serous (HGSOC). Because of its general low chemosensitivity, complete cytoreductive surgery with no residual disease is crucial in advanced stage LGSOC. We evaluated the impact of optimal cytoreduction on survival outcome both at first diagnosis and at recurrence.MethodsWe retrospectively studied consecutive patients diagnosed with advanced LGSOCs who underwent cytoreductive surgery in two oncological centers from January 1994 to December 2018. Survival curves were estimated by the Kaplan–Meier method, and 95% confidence intervals (95% CI) were estimated using the Greenwood formula.ResultsA total of 92 patients were included (median age was 47 years, IQR 35–64). The median overall survival (OS) was 142.3 months in patients with no residual disease (RD), 86.4 months for RD 1–10 mm and 35.2 months for RD >10 mm (p = 0.002). Progression-free survival (PFS) was inversely related to RD after primary cytoreductive surgery (RD = 0 vs RD = 1–10 mm vs RD >10 mm, p = 0.002). On multivariate analysis, RD 1–10 mm (HR = 2.30, 95% CI 1.30–4.06, p = 0.004), RD >10 mm (HR = 3.89, 95% CI 1.92–7.88, p = 0.0004), FIGO stage IV (p = 0.001), and neoadjuvant chemotherapy (NACT) (p = 0.010) were independent predictors of PFS. RD >10 mm (HR = 3.13, 95% CI 1.52–6.46, p = 0.004), FIGO stage IV (p ConclusionsOptimal cytoreductive surgery improves survival outcomes in advanced stage LGSOCs. When complete debulking is impossible, a RD 10 mm in this setting of patients.

Published
2022

19. Early-stage clear cell ovarian cancer compared to high-grade histological subtypes: An outcome exploratory analysis in two oncology centers

Author

Ceppi, L, Grassi, T, Galli, F, Buda, A, Aletti, G, Lissoni, A, Adorni, M, Garbi, A, Colombo, N, Bonazzi, C, Landoni, F, Fruscio, R, Ceppi L., Grassi T., Galli F., Buda A., Aletti G., Lissoni A. A., Adorni M., Garbi A., Colombo N., Bonazzi C., Landoni F., Fruscio R., Ceppi, L, Grassi, T, Galli, F, Buda, A, Aletti, G, Lissoni, A, Adorni, M, Garbi, A, Colombo, N, Bonazzi, C, Landoni, F, Fruscio, R, Ceppi L., Grassi T., Galli F., Buda A., Aletti G., Lissoni A. A., Adorni M., Garbi A., Colombo N., Bonazzi C., Landoni F., and Fruscio R.

Abstract

Objective: advanced stage clear cell ovarian cancer (CCOC) carries a higher risk of relapse and death compared to other histological subtypes. The prognosis of early-stage CCOC is controversial. Methods: Early-stage high-grade OC patients from two Italian oncologic centers were included. Patients with early-stage CCOC were compared with those with high-grade endometrioid (HGE) and serous (HGS) OC in terms of relapse-free interval (RFI), cancer-specific survival (CSS) and post relapse cancer-specific survival (prCSS). The Cox proportional hazard model and the restricted mean survival time were used. Results: Between 1981 and 2012, 134 patients with CC, 152 with HGE and 160 with HGS were treated at two referral centers. Median follow-up was 11.5 years. Ten years RFI rates were 80.6%, 72.1%, 60.6%, and CSS rates were 84.3%, 82.6%, 81.7% respectively. Adjuvant chemotherapy significantly improved RFI (aHR 0.61, 95%CI 0.40 to 0.91, P = 0.015). In the multivariable analysis HGS histotype was associated with a shorter RFI compared to CC, (Hazard Ratio [HR]: 1.81; 95%CI: 1.12–2.93; P = 0.016), whereas CSS was not statistically different. prCSS was longer in HGS compared to CCOC (HR, 0.36; 95% CI, 0.17–0.74; P = 0.006). According to the stage, IA/IB/IC1 HGSOC had a shorter RFI (HR, 2.13; 95% CI, 1.14–3.99; P = 0.018) compared to IA/IB/IC1 CCOC, but similar CSS. For prCSS, CC compared to HGS conferred a worse prognosis regardless of the initial stage. Conclusions: Early-stage CCOC is associated with a longer RFI, similar CSS and a shorter prCSS compared to HGSOC. No prognostic differences were observed between CC and HGE OC. The relapse risk was the lowest in IA/IB/IC1 CC compared to HGS, whereas CC displayed poor sensitivity to chemotherapy after relapse.

Published
2021

20. Middleware and Architectural Reflection

Author

Adorni, M., Arcelli, F., Baldoni, R., Beraldi, R., Limonta, A., Locatelli, M., Losi, P., Marchetti, C., Milani, A., Querzoni, L., Raibulet, C., Sarini, M., Simone, C., Tisato, F., Piergiovanni, S. Tucci, Virgillito, A., Vizzari, G., and Pernici, Barbara, editor

Published
2006
Full Text
View/download PDF

21. Reference Architecture and Framework

Author

Adorni, M., Arcelli, F., Bandini, S., Baresi, L., Batini, C., Bianchi, A., Bianchini, D., Brioschi, M., Caforio, A., Calì, A., Cappellari, P., Cappiello, C., Catarci, T., Corallo, A., De Antonellis, V., Franza, C., Giunta, G., Limonta, A., Lorenzo, G., Losi, P., Maurino, A., Melideo, M., Micucci, D., Modafferi, S., Mussi, E., Negri, L., Pandolfo, C., Pernici, B., Plebani, P., Ragazzi, D., Raibulet, C., Riva, M., Simeoni, N., Simone, C., Solazzo, G., Tisato, F., Torlone, R., Vizzari, G., Zilli, A., and Pernici, Barbara, editor

Published
2006
Full Text
View/download PDF

22. Impact of invasive alien plants on native plant communities and Natura 2000 habitats: State of the art, gap analysis and perspectives in Italy

Author

Lazzaro, L, Bolpagni, R, Buffa, G, Gentili, R, Lonati, M, Stinca, A, Acosta, A, Adorni, M, Aleffi, M, Allegrezza, M, Angiolini, C, Assini, S, Bagella, S, Bonari, G, Bovio, M, Bracco, F, Brundu, G, Caccianiga, M, Carnevali, L, Di Cecco, V, Ceschin, S, Ciaschetti, G, Cogoni, A, Foggi, B, Frattaroli, A, Genovesi, P, Gigante, D, Lucchese, F, Mainetti, A, Mariotti, M, Minissale, P, Paura, B, Pellizzari, M, Perrino, E, Pirone, G, Poggio, L, Poldini, L, Poponessi, S, Prisco, I, Prosser, F, Puglisi, M, Rosati, L, Selvaggi, A, Sottovia, L, Spampinato, G, Stanisci, A, Venanzoni, R, Viciani, D, Vidali, M, Villani, M, Lastrucci, L, Lazzaro L., Bolpagni R., Buffa G., Gentili R., Lonati M., Stinca A., Acosta A. T. R., Adorni M., Aleffi M., Allegrezza M., Angiolini C., Assini S., Bagella S., Bonari G., Bovio M., Bracco F., Brundu G., Caccianiga M., Carnevali L., Di Cecco V., Ceschin S., Ciaschetti G., Cogoni A., Foggi B., Frattaroli A. R., Genovesi P., Gigante D., Lucchese F., Mainetti A., Mariotti M., Minissale P., Paura B., Pellizzari M., Perrino E. V., Pirone G., Poggio L., Poldini L., Poponessi S., Prisco I., Prosser F., Puglisi M., Rosati L., Selvaggi A., Sottovia L., Spampinato G., Stanisci A., Venanzoni R., Viciani D., Vidali M., Villani M., Lastrucci L., Lazzaro, L, Bolpagni, R, Buffa, G, Gentili, R, Lonati, M, Stinca, A, Acosta, A, Adorni, M, Aleffi, M, Allegrezza, M, Angiolini, C, Assini, S, Bagella, S, Bonari, G, Bovio, M, Bracco, F, Brundu, G, Caccianiga, M, Carnevali, L, Di Cecco, V, Ceschin, S, Ciaschetti, G, Cogoni, A, Foggi, B, Frattaroli, A, Genovesi, P, Gigante, D, Lucchese, F, Mainetti, A, Mariotti, M, Minissale, P, Paura, B, Pellizzari, M, Perrino, E, Pirone, G, Poggio, L, Poldini, L, Poponessi, S, Prisco, I, Prosser, F, Puglisi, M, Rosati, L, Selvaggi, A, Sottovia, L, Spampinato, G, Stanisci, A, Venanzoni, R, Viciani, D, Vidali, M, Villani, M, Lastrucci, L, Lazzaro L., Bolpagni R., Buffa G., Gentili R., Lonati M., Stinca A., Acosta A. T. R., Adorni M., Aleffi M., Allegrezza M., Angiolini C., Assini S., Bagella S., Bonari G., Bovio M., Bracco F., Brundu G., Caccianiga M., Carnevali L., Di Cecco V., Ceschin S., Ciaschetti G., Cogoni A., Foggi B., Frattaroli A. R., Genovesi P., Gigante D., Lucchese F., Mainetti A., Mariotti M., Minissale P., Paura B., Pellizzari M., Perrino E. V., Pirone G., Poggio L., Poldini L., Poponessi S., Prisco I., Prosser F., Puglisi M., Rosati L., Selvaggi A., Sottovia L., Spampinato G., Stanisci A., Venanzoni R., Viciani D., Vidali M., Villani M., and Lastrucci L.

Abstract

Invasive alien plants are a major threat to biodiversity and they contribute to the unfavourable conservation status of habitats of interest to the European Community. In order to favour implementation of European Union Regulation no. 1143/2014 on invasive alien species, the Italian Society of Vegetation Science carried out a large survey led by a task force of 49 contributors with expertise in vegetation across all the Italian administrative regions. The survey summed up the knowledge on impact mechanisms of invasive alien plants in Italy and their outcomes on plant communities and the EU habitats of Community Interest, in accordance with Directive no. 92/43/EEC. The survey covered 241 alien plant species reported as having deleterious ecological impacts. The data collected illustrate the current state of the art, highlight the main gaps in knowledge, and suggest topics to be further investigated. In particular, the survey underlined competition as being the main mechanism of ecological impact on plant communities and Natura 2000 habitats. Of the 241 species, only Ailanthus altissima was found to exert an ecological impact on plant communities and Natura 2000 habitats in all Italian regions; while a further 20 species impact up to ten out of the 20 Italian administrative regions. Our data indicate that 84 out of 132 Natura 2000 Habitats (64%) are subjected to some degree of impact by invasive alien plants. Freshwater habitats and natural and semi-natural grassland formations were impacted by the highest number of alien species, followed by coastal sand dunes and inland dunes, and forests. Although not exhaustive, this research is the first example of nationwide evaluation of the ecological impacts of invasive alien plants on plant communities and Natura 2000 Habitats.

Published
2020

23. Notulae to the Italian alien vascular flora: 9

Author

Galasso, G, Domina, G, Adorni, M, Angiolini, C, Apruzzese, M, Ardenghi, N, Assini, S, Aversa, M, Bacchetta, G, Banfi, E, Barberis, G, Bartolucci, F, Bernardo, L, Bertolli, A, Bonali, F, Bonari, G, Bonini, I, Bracco, F, Brundu, G, Buccomino, G, Buono, S, Calvia, G, Cambria, S, Castagnini, P, Ceschin, S, Dagnino, D, Di Gristina, E, Di Turi, A, Fascetti, S, Ferretti, G, Fois, M, Gentili, R, Gheza, G, Gubellini, L, Hofmann, N, Iamonico, D, Ilari, A, Kiraly, A, Kiraly, G, Laface, V, Lallai, A, Lazzaro, L, Lonati, M, Longo, D, Lozano, V, Lupoletti, J, Magrini, S, Mainetti, A, Manca, M, Marchetti, D, Mariani, F, Mariotti, M, Masin, R, Mei, G, Menini, F, Merli, M, Milani, A, Minuto, L, Mugnai, M, Musarella, C, Olivieri, N, Onnis, L, Passalacqua, N, Peccenini, S, Peruzzi, L, Pica, A, Pinzani, L, Pittarello, M, Podda, L, Prosser, F, Enri, S, Roma-Marzio, F, Rosati, L, Sarigu, M, Scafidi, F, Sciandrello, S, Selvaggi, A, Spampinato, G, Stinca, A, Tavilla, G, Toffolo, C, Tomasi, G, Turcato, C, Villano, C, Nepi, C, Galasso G., Domina G., Adorni M., Angiolini C., Apruzzese M., Ardenghi N. M. G., Assini S., Aversa M., Bacchetta G., Banfi E., Barberis G., Bartolucci F., Bernardo L., Bertolli A., Bonali F., Bonari G., Bonini I., Bracco F., Brundu G., Buccomino G., Buono S., Calvia G., Cambria S., Castagnini P., Ceschin S., Dagnino D., Di Gristina E., Di Turi A., Fascetti S., Ferretti G., Fois M., Gentili R., Gheza G., Gubellini L., Hofmann N., Iamonico D., Ilari A., Kiraly A., Kiraly G., Laface V. L. A., Lallai A., Lazzaro L., Lonati M., Longo D., Lozano V., Lupoletti J., Magrini S., Mainetti A., Manca M., Marchetti D., Mariani F., Mariotti M. G., Masin R. R., Mei G., Menini F., Merli M., Milani A., Minuto L., Mugnai M., Musarella C. M., Olivieri N., Onnis L., Passalacqua N. G., Peccenini S., Peruzzi L., Pica A., Pinzani L., Pittarello M., Podda L., Prosser F., Enri S. R., Roma-Marzio F., Rosati L., Sarigu M., Scafidi F., Sciandrello S., Selvaggi A., Spampinato G., Stinca A., Tavilla G., Toffolo C., Tomasi G., Turcato C., Villano C., Nepi C., Galasso, G, Domina, G, Adorni, M, Angiolini, C, Apruzzese, M, Ardenghi, N, Assini, S, Aversa, M, Bacchetta, G, Banfi, E, Barberis, G, Bartolucci, F, Bernardo, L, Bertolli, A, Bonali, F, Bonari, G, Bonini, I, Bracco, F, Brundu, G, Buccomino, G, Buono, S, Calvia, G, Cambria, S, Castagnini, P, Ceschin, S, Dagnino, D, Di Gristina, E, Di Turi, A, Fascetti, S, Ferretti, G, Fois, M, Gentili, R, Gheza, G, Gubellini, L, Hofmann, N, Iamonico, D, Ilari, A, Kiraly, A, Kiraly, G, Laface, V, Lallai, A, Lazzaro, L, Lonati, M, Longo, D, Lozano, V, Lupoletti, J, Magrini, S, Mainetti, A, Manca, M, Marchetti, D, Mariani, F, Mariotti, M, Masin, R, Mei, G, Menini, F, Merli, M, Milani, A, Minuto, L, Mugnai, M, Musarella, C, Olivieri, N, Onnis, L, Passalacqua, N, Peccenini, S, Peruzzi, L, Pica, A, Pinzani, L, Pittarello, M, Podda, L, Prosser, F, Enri, S, Roma-Marzio, F, Rosati, L, Sarigu, M, Scafidi, F, Sciandrello, S, Selvaggi, A, Spampinato, G, Stinca, A, Tavilla, G, Toffolo, C, Tomasi, G, Turcato, C, Villano, C, Nepi, C, Galasso G., Domina G., Adorni M., Angiolini C., Apruzzese M., Ardenghi N. M. G., Assini S., Aversa M., Bacchetta G., Banfi E., Barberis G., Bartolucci F., Bernardo L., Bertolli A., Bonali F., Bonari G., Bonini I., Bracco F., Brundu G., Buccomino G., Buono S., Calvia G., Cambria S., Castagnini P., Ceschin S., Dagnino D., Di Gristina E., Di Turi A., Fascetti S., Ferretti G., Fois M., Gentili R., Gheza G., Gubellini L., Hofmann N., Iamonico D., Ilari A., Kiraly A., Kiraly G., Laface V. L. A., Lallai A., Lazzaro L., Lonati M., Longo D., Lozano V., Lupoletti J., Magrini S., Mainetti A., Manca M., Marchetti D., Mariani F., Mariotti M. G., Masin R. R., Mei G., Menini F., Merli M., Milani A., Minuto L., Mugnai M., Musarella C. M., Olivieri N., Onnis L., Passalacqua N. G., Peccenini S., Peruzzi L., Pica A., Pinzani L., Pittarello M., Podda L., Prosser F., Enri S. R., Roma-Marzio F., Rosati L., Sarigu M., Scafidi F., Sciandrello S., Selvaggi A., Spampinato G., Stinca A., Tavilla G., Toffolo C., Tomasi G., Turcato C., Villano C., and Nepi C.

Abstract

In this contribution, new data concerning the distribution of vascular flora alien to Italy are presented. It includes new records, confirmations, exclusions, and status changes for Italy or for Italian administrative regions. Furthermore, three new combinations are proposed. Nomenclatural and distribution updates published elsewhere are provided as Suppl. material 1.

Published
2020

24. Detection of TP53 Clonal Variants in Papanicolaou Test Samples Collected up to 6 Years Prior to High-Grade Serous Epithelial Ovarian Cancer Diagnosis

Author

Paracchini, L, Pesenti, C, Delle Marchette, M, Beltrame, L, Bianchi, T, Grassi, T, Buda, A, Landoni, F, Ceppi, L, Bosetti, C, Paderno, M, Adorni, M, Vicini, D, Perego, P, Leone, B, D'Incalci, M, Marchini, S, Fruscio, R, Paracchini L., Pesenti C., Delle Marchette M., Beltrame L., Bianchi T., Grassi T., Buda A., Landoni F., Ceppi L., Bosetti C., Paderno M., Adorni M., Vicini D., Perego P., Leone B. E., D'Incalci M., Marchini S., Fruscio R., Paracchini, L, Pesenti, C, Delle Marchette, M, Beltrame, L, Bianchi, T, Grassi, T, Buda, A, Landoni, F, Ceppi, L, Bosetti, C, Paderno, M, Adorni, M, Vicini, D, Perego, P, Leone, B, D'Incalci, M, Marchini, S, Fruscio, R, Paracchini L., Pesenti C., Delle Marchette M., Beltrame L., Bianchi T., Grassi T., Buda A., Landoni F., Ceppi L., Bosetti C., Paderno M., Adorni M., Vicini D., Perego P., Leone B. E., D'Incalci M., Marchini S., and Fruscio R.

Abstract

Importance: The low 5-year survival rate of women with high-grade serous epithelial ovarian cancer (HGS-EOC) is related to its late diagnosis; thus, improvement in diagnosis constitutes a crucial step to increase the curability of this disease. Objective: To determine whether the presence of the clonal pathogenic TP53 variant detected in matched primary tumor biopsies can be identified in DNA purified from Papanicolaou test samples collected from women with HGS-EOC years before the diagnosis. Design, Setting, and Participants: This cohort study was conducted among a single-center cohort of women with histologically confirmed diagnosis of HGS-EOC recruited at San Gerardo Hospital, Monza, Italy, from October 15, 2015, to January 4, 2019. Serial dilutions of DNA derived from tumor samples and DNA extracted from healthy women's Papanicolaou test samples were analyzed to define the sensitivity and specificity of droplet digital polymerase chain reaction assays designed to detect the TP53 variants identified in tumors. All available brush-based Papanicolaou test slides performed up to 6 years before diagnosis were investigated at the Mario Negri Institute, Milano, Italy. Data were analyzed from October 2018 to December 2019. Main Outcomes and Measures: The presence of tumor pathogenic TP53 variants was assessed by the droplet digital polymerase chain reaction approach in DNA purified from Papanicolaou test samples obtained from the same patients before diagnosis during cervical cancer screenings. Results: Among 17 included patients (median [interquartile range] age at diagnosis, 60 [53-69] years), Papanicolaou tests withdrawn before diagnosis presented tumor-matched TP53 variants in 11 patients (64%). In 2 patients for whom longitudinal Papanicolaou tests were available, including 1 patient with Papanicolaou tests from 25 and 49 months before diagnosis and 1 patient with Papanicolaou tests from 27 and 68 months before diagnosis, the TP53 clonal variant was detected at all

Published
2020

25. Current status of Melcor 2.2 for fusion safety analyses

Author

Mascari, F., Bersano, A., Adorni, M., D`Ovidio, G., Martin-Fuertes, F., Jin, X. Z., Mazzini, G., Gonfiotti, B., Georgiev, G., Leskovar, M., Bertani, C., Testoni, R., Giannetti, F., D`Onorio, M., Agnello, G., Maio, P. A. Di, Angelucci, M., Paci, S., Grippo, G., Malicki, M., Fernandez-Cosials, K., Dongiovanni, D., and Luxat, D.

Subjects
Technology, ddc:600
Published
2022
Full Text
View/download PDF

28. O004/#393 Does intensive follow-up improve overall survivalin endometrial cancer patients? Results from the totem randomized controlled trial

Author

Zola, P, primary, Ciccone, G, additional, Angioli, R, additional, Terranova, C, additional, Piovano, E, additional, Fuso, L, additional, Di Cuonzo, D, additional, Peirano, E, additional, Perrone, AM, additional, Mandato, VD, additional, Zavallone, L, additional, Chiudinelli, F, additional, Berretta, R, additional, Loda, S, additional, Greggi, S, additional, Adorni, M, additional, Busato, E, additional, Comerci, G, additional, Fambrini, M, additional, and Ferrero, A, additional

Published
2021
Full Text
View/download PDF

29. 259 The impact of intensive follow-up on health-related quality of life and costs in endometrial cancer patients: data from the TOTEM trial NCT00916708

Author

Zola, P, primary, Ciccone, G, additional, Piovano, E, additional, Fuso, L, additional, Peirano, E, additional, Cuonzo, DDI, additional, Pagano, E, additional, Castiglione, A, additional, Perrone, AM, additional, Mandato, VD, additional, Zavallone, L, additional, Chiudinelli, F, additional, Berretta, R, additional, Loda, S, additional, Valenzano Menada, M, additional, Greggi, S, additional, Adorni, M, additional, Comerci, G, additional, Fambrini, M, additional, and Ferrero, A, additional

Published
2021
Full Text
View/download PDF

32. Genome-wide Copy-number Alterations in Circulating Tumor DNA as a Novel Biomarker for Patients with High-grade Serous Ovarian Cancer

Author

Paracchini, L, Beltrame, L, Grassi, T, Inglesi, A, Fruscio, R, Landoni, F, Ippolito, D, Delle Marchette, M, Paderno, M, Adorni, M, Jaconi, M, Romualdi, C, D'Incalci, M, Siravegna, G, Marchini, S, Paracchini, Lara, Beltrame, Luca, Grassi, Tommaso, Inglesi, Alessia, Fruscio, Robert, Landoni, Fabio, Ippolito, Davide, Delle Marchette, Martina, Paderno, Mariachiara, Adorni, Marco, Jaconi, Marta, Romualdi, Chiara, D'Incalci, Maurizio, Siravegna, Giulia, Marchini, Sergio, Paracchini, L, Beltrame, L, Grassi, T, Inglesi, A, Fruscio, R, Landoni, F, Ippolito, D, Delle Marchette, M, Paderno, M, Adorni, M, Jaconi, M, Romualdi, C, D'Incalci, M, Siravegna, G, Marchini, S, Paracchini, Lara, Beltrame, Luca, Grassi, Tommaso, Inglesi, Alessia, Fruscio, Robert, Landoni, Fabio, Ippolito, Davide, Delle Marchette, Martina, Paderno, Mariachiara, Adorni, Marco, Jaconi, Marta, Romualdi, Chiara, D'Incalci, Maurizio, Siravegna, Giulia, and Marchini, Sergio

Abstract

Purpose: High-grade serous epithelial ovarian cancer (HGS-EOC) is defined by high levels of somatic copy-number alterations (SCNA) with marked spatial and temporal tumor heterogeneity. Biomarkers serving to monitor drug response and detect disease recurrence are lacking, a fact which reflects an unmet clinical need. Experimental Design: A total of 185 plasma samples and 109 matched tumor biopsies were collected from 46 patients with HGS-EOC, and analyzed by shallow whole-genome sequencing (sWGS). The percentage of tumor fraction (TF) in the plasma was used to study the biological features of the disease at the time of diagnosis (T0) and correlated with patients' survival. Longitudinal analysis of TF was correlated with CA-125 levels and radiological images to monitor disease recurrence. Results: Gain in the clonal regions, 3q26.2 and 8q24.3, was observed in the 87.8% and 78.05% of plasma samples, suggesting that plasmas WGS mirrors solid biopsies. AtT0, multivariate analysis revealed that plasma TF levels were an independent prognostic marker of relapse (P < 0.022). After platinum (Pt)-based treatment, circulating tumor DNA (ctDNA) analysis showed a change in the heterogeneous pattern of genomic amplification, including an increased frequency of amplification, compared with before Ptbased treatment in the 19p31.11 and 19q13.42 regions. TF in serially collected ctDNA samples outperformed CA-125 in anticipating clinical and radiological progression by 240 days (range, 37-491). Conclusions: Our results support the notion that sWGS is an inexpensive and useful tool for the genomic analysis of ctDNA in patients with HGS-EOC to monitor disease evolution and to anticipate relapse better than serum CA-125, the routinely used clinical biomarker.

Published
2021

33. Correction to: The impact of low-volume metastasis on disease-free survival of women with early-stage cervical cancer (Journal of Cancer Research and Clinical Oncology, (2020), 10.1007/s00432-020-03435-z)

Author

Buda, A., Casarin, J., Mueller, M., Fanfani, Francesco, Zapardiel, I., Mereu, L., Puppo, A., De Ponti, E., Adorni, M., Ferrari, D., Gasparri, M. L., Ghezzi, F., Scambia, Giovanni, Papadia, A., Fanfani F. (ORCID:0000-0003-1991-7284), Scambia G. (ORCID:0000-0003-2758-1063), Buda, A., Casarin, J., Mueller, M., Fanfani, Francesco, Zapardiel, I., Mereu, L., Puppo, A., De Ponti, E., Adorni, M., Ferrari, D., Gasparri, M. L., Ghezzi, F., Scambia, Giovanni, Papadia, A., Fanfani F. (ORCID:0000-0003-1991-7284), and Scambia G. (ORCID:0000-0003-2758-1063)

Abstract

In the original article, the name of the second author is incorrect.

Published
2021

35. A first checklist of the alien-dominated vegetation in Italy

Author

Viciani, D, Vidali, M, Gigante, D, Bolpagni, R, Villani, M, Acosta, A, Adorni, M, Aleffi, M, Allegrezza, M, Angiolini, C, Assini, S, Bagella, S, Bonari, G, Bovio, M, Bracco, F, Brundu, G, Buffa, G, Caccianiga, M, Carnevali, L, Ceschin, S, Ciaschetti, G, Cogoni, A, Di Cecco, V, Foggi, B, Frattaroli, A, Genovesi, P, Gentili, R, Lazzaro, L, Lonati, M, Lucchese, F, Mainetti, A, Mariotti, M, Minissale, P, Paura, B, Pellizzari, M, Perrino, E, Pirone, G, Poggio, L, Poldini, L, Poponessi, S, Prisco, I, Prosser, F, Puglisi, M, Rosati, L, Selvaggi, A, Sottovia, L, Spampinato, G, Stanisci, A, Stinca, A, Venanzoni, R, Lastrucci, L, Viciani, Daniele, Vidali, Marisa, Gigante, Daniela, Bolpagni, Rossano, Villani, Mariacristina, Acosta, Alicia Teresa Rosario, Adorni, Michele, Aleffi, Michele, Allegrezza, Marina, Angiolini, Claudia, Assini, Silvia, Bagella, Simonetta, Bonari, Gianmaria, Bovio, Maurizio, Bracco, Francesco, Brundu, Giuseppe, Buffa, Gabriella, Caccianiga, Marco, Carnevali, Lucilla, Ceschin, Simona, Ciaschetti, Giampiero, Cogoni, Annalena, Di Cecco, Valter, Foggi, Bruno, Frattaroli, Anna Rita, Genovesi, Piero, Gentili, Rodolfo, Lazzaro, Lorenzo, Lonati, Michele, Lucchese, Fernando, Mainetti, Andrea, Mariotti, Mauro, Minissale, Pietro, Paura, Bruno, Pellizzari, Mauro, Perrino, Enrico Vito, Pirone, Gianfranco, Poggio, Laura, Poldini, Livio, Poponessi, Silvia, Prisco, Irene, Prosser, Filippo, Puglisi, Marta, Rosati, Leonardo, Selvaggi, Alberto, Sottovia, Lucio, Spampinato, Giovanni, Stanisci, Angela, Stinca, Adriano, Venanzoni, Roberto, Lastrucci, Lorenzo, Viciani, D, Vidali, M, Gigante, D, Bolpagni, R, Villani, M, Acosta, A, Adorni, M, Aleffi, M, Allegrezza, M, Angiolini, C, Assini, S, Bagella, S, Bonari, G, Bovio, M, Bracco, F, Brundu, G, Buffa, G, Caccianiga, M, Carnevali, L, Ceschin, S, Ciaschetti, G, Cogoni, A, Di Cecco, V, Foggi, B, Frattaroli, A, Genovesi, P, Gentili, R, Lazzaro, L, Lonati, M, Lucchese, F, Mainetti, A, Mariotti, M, Minissale, P, Paura, B, Pellizzari, M, Perrino, E, Pirone, G, Poggio, L, Poldini, L, Poponessi, S, Prisco, I, Prosser, F, Puglisi, M, Rosati, L, Selvaggi, A, Sottovia, L, Spampinato, G, Stanisci, A, Stinca, A, Venanzoni, R, Lastrucci, L, Viciani, Daniele, Vidali, Marisa, Gigante, Daniela, Bolpagni, Rossano, Villani, Mariacristina, Acosta, Alicia Teresa Rosario, Adorni, Michele, Aleffi, Michele, Allegrezza, Marina, Angiolini, Claudia, Assini, Silvia, Bagella, Simonetta, Bonari, Gianmaria, Bovio, Maurizio, Bracco, Francesco, Brundu, Giuseppe, Buffa, Gabriella, Caccianiga, Marco, Carnevali, Lucilla, Ceschin, Simona, Ciaschetti, Giampiero, Cogoni, Annalena, Di Cecco, Valter, Foggi, Bruno, Frattaroli, Anna Rita, Genovesi, Piero, Gentili, Rodolfo, Lazzaro, Lorenzo, Lonati, Michele, Lucchese, Fernando, Mainetti, Andrea, Mariotti, Mauro, Minissale, Pietro, Paura, Bruno, Pellizzari, Mauro, Perrino, Enrico Vito, Pirone, Gianfranco, Poggio, Laura, Poldini, Livio, Poponessi, Silvia, Prisco, Irene, Prosser, Filippo, Puglisi, Marta, Rosati, Leonardo, Selvaggi, Alberto, Sottovia, Lucio, Spampinato, Giovanni, Stanisci, Angela, Stinca, Adriano, Venanzoni, Roberto, and Lastrucci, Lorenzo

Abstract

This study provides a first step toward the knowledge of the alien-dominated and co-dominated plant communities present in Italy. The first ever checklist of the alien phytocoenoses described or reported in literature for the Italian territory has been compiled, produced by data-mining in national and local thematic literature. The resulting vegetation-type draft-list has been checked in the light of the most recent syntaxonomic documentation and updated with regards to syntaxonomy and nomenclature, with special reference to the frame proposed in the Italian Vegetation Prodrome. The list includes 27 vascular and one bryophyte vegetation classes, hosting 194 low rank alien-dominated syntaxa . The different vegetation types detected for each syntaxonomic class and macro-vegetation group, defined by physiognomical and ecological attributes, are discussed.

Published
2020

36. Imact of bevacizumab-containing primary treatment on outcome of recurrent ovarian cancer: An Italian study

Author

Gadducci, A, Cosio, S, Lissoni, A, Zizioli, V, Adorni, M, Ferrero, A, Landoni, F, Sartori, E, Gadducci, Angiolo, Cosio, Stefania, Lissoni, Andrea Alberto, Zizioli, Valentina, Adorni, Marco, Ferrero, Anna Maria, Landoni, Fabio, Sartori, Enrico, Gadducci, A, Cosio, S, Lissoni, A, Zizioli, V, Adorni, M, Ferrero, A, Landoni, F, Sartori, E, Gadducci, Angiolo, Cosio, Stefania, Lissoni, Andrea Alberto, Zizioli, Valentina, Adorni, Marco, Ferrero, Anna Maria, Landoni, Fabio, and Sartori, Enrico

Abstract

Background/Aim: The aim of the study was to assess the outcome of advanced ovarian cancer patients who i) underwent primary surgery followed by carboplatin/paclitaxel-based chemotherapy with or without bevacizumab, ii) were in complete response after chemotherapy, iii) and subsequently recurred. Patients and Methods: The hospital records of 138 complete responders after chemotherapy with (n=58) or without (n=80) bevacizumab were reviewed. Results: Both survival after recurrence and overall survival were related to age (=61 vs. >61 years, p=0.002 and p=0.0001), performance status (0 vs. =1, p=0.002 and p=0.001), histotype (serous vs. non serous, p=0.005 and p=0.01), time to recurrence (=12 vs. <12 months, p<0.0001 and p<0.0001) and treatment at recurrence (surgery plus chemotherapy vs. chemotherapy, p=0.01 and p=0.004), but not to first-line treatment. Conclusion: This investigation failed to detect a more aggressive behavior of recurrent ovarian cancer after bevacizumab-containing primary treatment.

Published
2020

37. Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high-grade serous ovarian cancer

Author

Benvenuto, G, Todeschini, P, Paracchini, L, Calura, E, Fruscio, R, Romani, C, Beltrame, L, Martini, P, Ravaggi, A, Ceppi, L, Sales, G, Donati, F, Perego, P, Zanotti, L, Ballabio, S, Grassi, T, Marchette, M, Tognon, G, Sartori, E, Adorni, M, Odicino, F, D'Incalci, M, Bignotti, E, Romualdi, C, Marchini, S, Benvenuto, Giuseppe, Todeschini, Paola, Paracchini, Lara, Calura, Enrica, Fruscio, Robert, Romani, Chiara, Beltrame, Luca, Martini, Paolo, Ravaggi, Antonella, Ceppi, Lorenzo, Sales, Gabriele, Donati, Federica, Perego, Patrizia, Zanotti, Laura, Ballabio, Sara, Grassi, Tommaso, Marchette, Martina Delle, Tognon, Germana, Sartori, Enrico, Adorni, Marco, Odicino, Franco, D'Incalci, Maurizio, Bignotti, Eliana, Romualdi, Chiara, Marchini, Sergio, Benvenuto, G, Todeschini, P, Paracchini, L, Calura, E, Fruscio, R, Romani, C, Beltrame, L, Martini, P, Ravaggi, A, Ceppi, L, Sales, G, Donati, F, Perego, P, Zanotti, L, Ballabio, S, Grassi, T, Marchette, M, Tognon, G, Sartori, E, Adorni, M, Odicino, F, D'Incalci, M, Bignotti, E, Romualdi, C, Marchini, S, Benvenuto, Giuseppe, Todeschini, Paola, Paracchini, Lara, Calura, Enrica, Fruscio, Robert, Romani, Chiara, Beltrame, Luca, Martini, Paolo, Ravaggi, Antonella, Ceppi, Lorenzo, Sales, Gabriele, Donati, Federica, Perego, Patrizia, Zanotti, Laura, Ballabio, Sara, Grassi, Tommaso, Marchette, Martina Delle, Tognon, Germana, Sartori, Enrico, Adorni, Marco, Odicino, Franco, D'Incalci, Maurizio, Bignotti, Eliana, Romualdi, Chiara, and Marchini, Sergio

Abstract

High-grade serous ovarian cancer (HGS-EOCs) is generally sensitive to front-line platinum (Pt)-based chemotherapy although most patients at an advanced stage relapse with progressive resistant disease. Clinical or molecular data to identify primary resistant cases at diagnosis are not yet available. HGS-EOC biopsies from 105 Pt-sensitive (Pt-s) and 89 Pt-resistant (Pt-r) patients were retrospectively selected from two independent tumor tissue collections. Pathway analysis was done integrating miRNA and mRNA expression profiles. Signatures were further validated in silico on a cohort of 838 HGS-EOC cases from a published dataset. In all, 131 mRNAs and 5 miRNAs belonging to different functionally related molecular pathways distinguish Pt-s from Pt-r cases. Then, 17 out of 23 selected elements were validated by orthogonal approaches (SI signature). As resistance to Pt is associated with a short progression-free survival (PFS) and overall survival (OS), the prognostic role of the SI signature was assessed, and 14 genes associated with PFS and OS, in multivariate analyses (SII signature). The prognostic value of the SII signature was validated in a third extensive cohort. The expression profiles of SDF2L1, PPP1R12A and PRKG1 genes (SIII signature) served as independent prognostic biomarkers of Pt-response and survival. The study identified a prognostic molecular signature based on the combined expression profile of three genes which had never been associated with the clinical outcome of HGS-EOC. This may lead to early identification, at the time of diagnosis, of patients who would not greatly benefit from standard chemotherapy and are thus eligible for novel investigational approaches.

Published
2020

39. Un primo contributo alla definizione delle fitocenosi dominate da specie aliene in Italia

Author

Bolpagni, R., Acosta, A. T. C., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S. P., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A., Genovesi, P., Gentili, R., Gigante, D., Lazzaro, L., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, C., Lastrucci, L., AA.VV., Bolpagni, R., Acosta, A. T. C., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S. P., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A., Genovesi, P., Gentili, R., Gigante, D., Lazzaro, L., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E., Pirone, Gianfranco, Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, C., and Lastrucci, L.

Subjects
Alien species, habitat, vegettion, Italy
Published
2018

40. An assessment of the impacts of invasive alien plants on habitats in Italy: first results from the ISPRA-SISV convention

Author

Lazzaro L., Bolpagni R., Acosta A. T. R., Adorni M., Aleffi M., Allegrezza M., Angiolini C., Assini S. P., Bagella S., Bonari G., Bovio M., Bracco F., Brundu G., Buffa G., Caccianiga M., Carnevali L., Ceschin S., Ciaschetti G, Cogoni A., Di Cecco V., Foggi B., Frattaroli A. R., Genovesi P., Gentili R., Gigante D., Lonati M., Lucchese F., Mainetti A., Mariotti M., Minissale P., Paura B., Pellizzari M., Perrino E. V., Pirone G., Poggio L., Poldini L., Poponessi S., Prisco I., Prosser F., Puglisi M., Rosati L., Selvaggi A., Sottovia L., Spampinato G., Stanisci A., Stinca A., Venanzoni R., Viciani D., Vidali M., Villani C., Lastrucci L., AA.VV., Lazzaro, L., Bolpagni, R., Acosta, A. T. R., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S. P., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G, Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A. R., Genovesi, P., Gentili, R., Gigante, D., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E. V., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, C., and Lastrucci, L.

Subjects
Invasive alien plants, habitat, Habitat, invasive alien species, Habitat, invasive alien species
Published
2018

41. MELCOR 2.2 Modelling for Fusion Reactor Analysis

Author

Mascari, F., Adorni, M., Ha, S., D’Ovidio, Fuertes, F. M., Gonfiotti, B., Jin, X. Z., Mazzini, G., Georgiev, G., Leskovar, M., Bertani, C., Bersano, A., Giannetti, F., Donorio, M., Martelli, D., and Paci, S.

Subjects
MELCOR, fusion plant safety
Published
2019

42. Il Reporting ex-Art. 17 degli Habitat di All. I alla Direttiva 92/43/CEE in Italia: metodi, criticità, stato dell'arte e prospettive future

Author

Gigante, D., Selvaggi, A., Acosta, A. T. R., Adorni, M., Allegrezza, M., Angiolini, C., Armiraglio, S., Assini, S., Attorre, F., Bagella, S., Barcella, M., Bazan, G., Bertacchi, A., Bolpagni, R., Bonari, G., Buffa, G., Caccianiga, M., Cacciatori, C., Caria, M. C., Casavecchia, S., Casella, L., Cerabolini, B. E. L., Ciaschetti, G., Ciccarelli, D., Cogoni, A., Cutini, M., De Sanctis, M., De Simone, W., Del Vecchio, S., Di Cecco, V., Di Martino, L., Di Musciano, M., Fantinato, E., Filesi, L., Foggi, B., Forte, L., Frattaroli, A. R., Galdenzi, D., Gangale, C., Gianguzzi, L., Giusso Del Galdo, G., Grignetti, A., Guarino, R., Lasen, C., Maneli, F., Marcenò, C., Mariotti, M. G., Oriolo, G., Paura, B., Perrino, E., Pesaresi, S., Pezzi, G., Pisanu, S., Poponessi, S., Prisco, I., Puglisi, M., Rivieccio, G., Sciandrello, S., Spampinato, G., Stinca, A., Strumia, S., Taffetani, F., Tesei, G., Tomaselli, V., Venanzoni, R., Viciani, D., Villani, M., Wagensommer, R., Zanatta, K., and Angelini, P.

Subjects
Habitat, conservation, Europeand Directive
Published
2019

43. An overview of the Italian forest biodiversity and its conservation level, based on the first outcomes of the 4th Habitat Report ex-Art. 17

Author

Gigante, D., Selvaggi, A., Acosta Alicia, T., Adorni, M., Allegrezza, M., Angiolini, C., Armiraglio, S., Assini, S., Attorre, F., Bagella, S., Barcella, M., Giuseppe Bazan, Bertacchi, A., Bolpagni, R., Bonari, G., Buffa, G., Caccianiga Marco Stefano, Cacciatori, C., Carmela, C., Casavecchia, S., Casella, L., Cerabolini Bruno, E., Ciaschetti, G., Ciccarelli, D., Cogoni, A., Cutini, M., De Sanctis Michele, De Simone Walter, Del Vecchio Silvia, Di Cecco Valter, Di Martino Luciano, Di Musciano Michele, Fantinato, E., Filesi, L., Foggi, B., Forte, L., Frattaroli Anna Rita, Galdenzi, D., Gangale, C., lorenzo gianguzzi, Giusso Del Galdo Gianpietro, Grignetti, A., Riccardo Guarino, Lasen, C., Maneli, F., Marcenò, C., Mariotti Mauro Giorgio, Oriolo, G., Paura, B., Perrino, E., Pesaresi, S., Pezzi, G., Pisanu, S., Poponessi, S., Prisco, I., Puglisi, M., Rivieccio, G., Sciandrello, S., Spampinato, G., Stinca, A., Strumia, S., Taffetani, F., Tesei, G., Tomaselli, V., Venanzoni, R., Viciani, D., Villani, M., Wagensommer Robert Philipp, Zanatta, K., Angelini, P., Società Botanica Italiana, Gigante, Daniela, Selvaggi, Alberto, Acosta Alicia, T. R., Adorni, Michele, Allegrezza, Marina, Angiolini, Claudia, Armiraglio, Stefano, Assini, Silvia, Attorre, Fabio, Bagella, Simonetta, Barcella, Matteo, Bazan, Giuseppe, Bertacchi, Andrea, Bolpagni, Rossano, Bonari, Gianmaria, Buffa, Gabriella, Caccianiga Marco, Stefano, Cacciatori, Cecilia, Caria Maria, Carmela, Casavecchia, Simona, Casella, Laura, Cerabolini Bruno, E. L., Ciaschetti, Giampiero, Ciccarelli, Daniela, Cogoni, Annalena, Cutini, Maurizio, De Sanctis, Michele, De Simone, Walter, Del Vecchio, Silvia, Di Cecco, Valter, Di Martino, Luciano, Di Musciano, Michele, Fantinato, Edy, Filesi, Leonardo, Foggi, Bruno, Forte, Luigi, Frattaroli Anna, Rita, Galdenzi, Diana, Gangale, Carmen, Gianguzzi, Lorenzo, Giusso Del Galdo, Gianpietro, Grignetti, Alessandra, Guarino, Riccardo, Lasen, Cesare, Maneli, Fabio, Marcenò, Corrado, Mariotti Mauro, Giorgio, Oriolo, Giuseppe, Paura, Bruno, Perrino, Enrico, Pesaresi, Simone, Pezzi, Giovanna, Pisanu, Stefania, Poponessi, Silvia, Prisco, Irene, Puglisi, Marta, Rivieccio, Giovanni, Sciandrello, Saverio, Spampinato, Giovanni, Stinca, Adriano, Strumia, Sandro, Taffetani, Fabio, Tesei, Giulio, Tomaselli, Valeria, Venanzoni, Roberto, Viciani, Daniele, Villani, Mariacristina, Wagensommer Robert, Philipp, Zanatta, Katia, Angelini, Paola, and Gigante Daniela, Selvaggi Alberto, Acosta Alicia T.R., Adorni Michele, Allegrezza Marina, Angiolini Claudia, Armiraglio Stefano, Assini Silvia, Attorre Fabio, Bagella Simonetta, Barcella Matteo, Bazan Giuseppe, Bertacchi Andrea, Bolpagni Rossano, Bonari Gianmaria, Buffa Gabriella, Caccianiga Marco Stefano, Cacciatori Cecilia, Caria Maria.Carmela, Casavecchia Simona, Casella Laura, Cerabolini Bruno E.L., Ciaschetti Giampiero, Ciccarelli Daniela, Cogoni Annalena, Cutini Maurizio, De Sanctis Michele, De Simone Walter, Del Vecchio Silvia, Di Cecco Valter, Di Martino Luciano, Di Musciano Michele, Fantinato Edy, Filesi Leonardo, Foggi Bruno, Forte Luigi, Frattaroli Anna Rita, Galdenzi Diana, Gangale Carmen, Gianguzzi Lorenzo, Giusso Del Galdo Gianpietro, Grignetti Alessandra, Guarino Riccardo, Lasen Cesare, Maneli Fabio, Marcenò Corrado, Mariotti Mauro Giorgio, Oriolo Giuseppe, Paura Bruno, Perrino Enrico, Pesaresi Simone, Pezzi Giovanna, Pisanu Stefania, Poponessi Silvia, Prisco Irene, Puglisi Marta, Rivieccio Giovanni, Sciandrello Saverio, Spampinato Giovanni, Stinca Adriano, Strumia Sandro, Taffetani Fabio, Tesei Giulio, Tomaselli Valeria, Venanzoni Roberto, Viciani Daniele, Villani Mariacristina, Wagensommer Robert Philipp, Zanatta Katia, Angelini Paola

Subjects
Habitat, Habitat, Italian forests, Vegetation Science, Natura 2000, Biodiversity conservation, Italian forests
Abstract

In 2019 the 4th Report ex-Art. 17 on the conservation status (CS) of Annex I Habitats of the 92/43/EEC Directive was expected by every EU/28 country, with reference to the period 2013-18. In Italy, the process was in charge to the Italian Institute for Environmental Protection and Research (ISPRA), on behalf of the Ministry for Environment, Land and Sea Protection (MATTM), with the scientific support of the Italian Botanical Society (SBI). A large group of thematic and territorial experts elaborated the available data concerning the 124 types of terrestrial and inland water Habitats present in Italy, 39 of which are represented by Forest Habitats (Group 9),. The main aim of the work was the evaluation of the overall CS of each Habitat by Biogeographic Region (Mediterranean, Continental and Alpine), for a total amount of 294 assessments. A high proportion of these (92, corresponding to 31% of the total) referred to Forest Habitats, including 20 marginal types for which the CS was not requested. The analysis was carried out at different scales: a) administrative territory, through the data contained in the ISPRA database, whose compilation was in charge to the Regions and Autonomous Provinces; b) Natura 2000 site, with the latest updates available (Standard Data Forms updated to 2018); c) national scale, implementing the distribution maps for each Habitat based on the European grid ETRS89-LAEA5210 (10x10 km2 mesh); d) Biogeographic Region, scale of the final assessment. Cartographic outcomes, associated databases and additional data used for the assessments will be available online on the ISPRA Portal as soon as the validation process by the European Commission will be completed. A dedicated archive named "HAB_IT" has been created in the national database "VegItaly" (1), managed by the Italian Society of Vegetation Science, where the phytosociological relevés representative of the various Annex I Habitats in Italy will be archived and freely accessible. An overview of the results regarding the Forest habitats is here provided, including a comparison with the outcomes of the former reporting cycle, the 3rd Report ex-Art. 17 (2). In several cases (e.g. 9120, 91L0), the distribution maps have been remarkably improved due to better knowledge and more fitful interpretation. The conservation status resulted as Favourable (FV) for 6,7%, Inadequate (U1) for 58,7% and Bad (U1) for 32,0% of the 72 assessed forest Habitat types. In no case there was an improvement of the conservation status, while in 6 cases a worsening of the conditions resulted from the data analysis, pointing out the Habitats types with a higher need of action. Similarly to other projects carried out as a team by the network of Annex I Habitat experts of the Italian Botanical Society and the Italian Society for Vegetation Science (e.g. 3, 4), this is another step in the direction of supporting the implementation of the 92/43/EEC "Habitat" Directive in Italy and Europe. On this ground, the high biodiversity of the Italian forest Habitats could be emphasized, however results pointed out that some rare or endemic types (e.g. Alnus cordata or Betula aetnensis-dominated forests) are still scarcely acknowledged by the most prominent EU conservation tools such as the Annex I to the "Habitat" Directive. 1) F. Landucci et al. (2012) Plant Biosyst., 146(4), 756-763 2) P. Genovesi et al. (2014) ISPRA, Serie Rapporti, 194/2014 3) E. Biondi et al. (2009) Società Botanica Italiana, MATTM, D.P.N., http://vnr.unipg.it/habitat/ 4) D. Gigante et al. (2016) Plant Sociology, 53(2), 77-87

Published
2019

44. La flora endemica minacciata delle montagne italiane

Author

Adorni, M., Alessandrini, A., Bacchetta, G., Bartolucci, F., Bernardo, L., Bovio, M., Carta, A., Cogoni, D., Conti, F., DI MARTINO, L., Domina, G., Fenu, G., Fois, M., Gestri, G., Guarino, R., Lasen, C., Manzi, A., Martini, F., Mazzola, P., Peruzzi, L., Pinna, M. S., Prosser, F., Raimondo, F. M., ROMA-MARZIO, F., Schicchi, R., Selvaggi, A., Stinca, A., and Sulis, E.

Published
2019

45. An overview of the Italian forest biodiversity and its conservation level, based on the first outcomes of the 4th Habitat Report ex-Art. 17. Communication IX

Author

Gigante, D., Selvaggi, A., Acosta, A. T. R., Adorni, M., Allegrezza, M., Angiolini, C., Armiraglio, S., Assini, S., Attorre, F., Bagella, S., Barcella, M., Bazan, G., Bertacchi, A., Bolpagni, R., Bonari, G., Buffa, G., Caccianiga, M., Cacciatori, C., Caria, M. C., Casavecchia, S., Casella, L., Cerabolini, B. E. L., Ciaschetti, G., Ciccarelli, D., Cogoni, A., Cutini, M., De Sanctis, M., De Simone, W., Del Vecchio, S., Di Cecco, V., Di Martino, L., Di Musciano, M., Fantinato, E., Filesi, L., Foggi, B., Forte, L., Frattaroli, A. R., Galdenzi, D., Gangale, C., Gianguzzi, L., Giusso Del Galdo, G., Grignetti, A., Guarino, R., Lasen, C., Maneli, F., Marcenò, C., Mariotti, M. G., Oriolo, G., Paura, B., Perrino, E., Pesaresi, S., Pezzi, G., Pisanu, S., Poponessi, S., Prisco, I., Puglisi, M., Rivieccio, G., Sciandrello, S., Spampinato, G., Stinca, A., Strumia, S., Taffetani, F., Tesei, G., Tomaselli, V., Venanzoni, R., Viciani, D., Villani, M., Wagensommer, R., Zanatta, K., and Angelini, P.

Subjects
Habitat, forests, conservation, monitoring, 92/43/EEC
Published
2019

46. Role of 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in malignant ovarian germ cell tumors: a single-center experience with long term follow-up

Author

Dolci, C, Ceppi, L, Guerra, L, Crivellaro, C, Lamanna, M, Adorni, M, Elisei, F, Bonazzi, C, Sina, F, Fruscio, R, Messa, C, ADORNI, MARCO, Bonazzi, CM, Dolci, C, Ceppi, L, Guerra, L, Crivellaro, C, Lamanna, M, Adorni, M, Elisei, F, Bonazzi, C, Sina, F, Fruscio, R, Messa, C, ADORNI, MARCO, and Bonazzi, CM

Abstract

Introduction 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is a diagnostic tool widely used in oncology, but to date there are no established recommendations for its use in malignant ovarian germ cell tumors. The aim of this study was to evaluate the role of 18F-FDG PET/CT in the clinical management of patients with malignant ovarian germ cell tumors. Methods This was a retrospective review of 18F-FDG PET/CT scans performed in patients diagnosed with malignant ovarian germ cell tumors treated at the gynecology department of San Gerardo Hospital (Monza, Italy) from June 2006 to December 2016. Data collected included clinical history, radiological, biochemical and pathological evaluation, treatment, follow-up, outcome, and clinical indication for the PET/CT scan. PET/CT findings were categorized as negative/normal (no abnormal FDG uptake or physiological uptake), positive/abnormal (FDG uptake considered to indicate active germ cell malignancy), or equivocal (FDG uptake of uncertain significance, not clearly correlated to neoplastic disease). Results A total of 69 PET/CT scans in 37 patients were evaluated. The mean age at diagnosis was 25 years (range 20–48). The majority of patients had International Federation of Gynecology and Obstetrics (FIGO) stage I (22/37) disease and had a diagnosis of dysgerminomas (18/37). Imaging indications were initial staging before treatment (4/69, 6%), staging after inadequate staging surgery (24/69, 35%), restaging after adjuvant chemotherapy (17/69, 25%), relapse suspect (9/69, 13%), and follow-up (15/69, 21%). Pathology confirmation of PET/CT results was available in 28/69 (40.5%) studies. All negative PET/CT (15/28) cases were confirmed with laparoscopy as true negative; among 13/28 positive PET cases, histopathology confirmed 7 (54%) as true positive and 6 (46%) as false positive (5 inflammatory and 1 mature teratoma implants). Patient-based analysis showed 100% sensitivity, 71% specif

Published
2019

48. Una valutazione degli impatti delle piante alloctone invasive sugli habitat in Italia: primi risultati dalla convenzione ISPRA-SISV

Author

Lazzaro, L., Acosta, A. T. C., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S. P., Bagella, S., Bolpagni, R., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A., Genovesi, P., Gentili, R., Gigante, D., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, C., and Lastrucci, L.

Subjects
Alien plant, habitat, vegetation, Italy
Published
2018

49. EP1116 Integrated pathway analysis identifies a 3-gene signature predicting platinum response and outcome of high grade serous ovarian carcinoma patients

Author

Bignotti, E, primary, Benvenuto, G, additional, Paracchini, L, additional, Zanotti, L, additional, Romani, C, additional, Tognon, G, additional, Calura, E, additional, Vicini, D, additional, Adorni, M, additional, Paderno, MC, additional, Bianchi, T, additional, Odicino, F, additional, Sartori, E, additional, Ravaggi, A, additional, D'Incalci, M, additional, Marchini, S, additional, Todeschini, P, additional, and Romualdi, C, additional

Published
2019
Full Text
View/download PDF

50. 17 Standard ultrastaging (SU) compared to one-step nucleic acid amplification (OSNA) for sentinel lymph nodemetastasis detection in endometrial cancer patients: a retrospective large cohort comparison

Author

Buda, A, primary, Fanfani, F, additional, Monterossi, G, additional, Vecchione, F, additional, La Fera, E, additional, Adorni, M, additional, Vicini, D, additional, Gioé, A, additional, Di Martino, G, additional, De Ponti, E, additional, Zannoni, GF, additional, Perego, P, additional, Landoni, F, additional, and Scambia, G, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results