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1. A randomized first-in-human phase I trial of differentially adjuvanted Pfs48/45 malaria vaccines in Burkinabe adults

Author

Tiono, Alfred B., Plieskatt, Jordan L., Ouedraogo, Alphonse, Soulama, Ben Idriss, Miura, Kazutoyo, Bougouma, Edith C., Naghizadeh, Mohammad, Barry, Aissata, Yaro, Jean Baptist B., Ezinmegnon, Sem, Henry, Noelie, Ofori, Ebenezer Addo, Adu, Bright, Singh, Susheel K., Konkobo, Augustin, Bengtsson, Karin Lovgren, Diarra, Amidou, Carnrot, Cecilia, Reimer, Jenny M., Ouedraogo, Amidou, Tienta, Moussa, Long, Carole A., Ouedraogo, Issa N., Sagara, Issaka, Sirima, Sodiomon B., and Theisen, Michael

Subjects
United States. National Institute of Allergy and Infectious Diseases, Medical research, Medicine, Experimental, Malaria vaccine -- Product development, Glutamate -- Product development, Amino acids -- Product development, Antigens, Clinical trials, Malaria, Adults, Vaccines -- Product development, Immunoglobulin G, Plasmodium falciparum, Health care industry
Abstract

BACKGROUND. Malaria transmission-blocking vaccines aim to interrupt the transmission of malaria from one person to another. METHODS. The candidates R0.6C and ProC6C share the 6C domain of the Plasmodium falciparum sexual-stage antigen Pfs48/45. R0.6C utilizes the glutamate-rich protein (GLURP) as a carrier, and ProC6C includes a second domain (Pfs230-Pro) and a short 36-amino acid circumsporozoite protein (CSP) sequence. Healthy adults (n = 125) from a malaria-endemic area of Burkina Faso were immunized with 3 intramuscular injections, 4 weeks apart, of 30 [micro]g or 100 [micro]g R0.6C or ProC6C each adsorbed to Alhydrogel (AlOH) adjuvant alone or in combination with Matrix-M (15 [micro]g or 50 [micro]g, respectively). The allocation was random and double-blind for this phase I trial. RESULTS. The vaccines were safe and well tolerated with no vaccine-related serious adverse events. A total of 7 adverse events, mild to moderate in intensity and considered possibly related to the study vaccines, were recorded. Vaccine-specific antibodies were highest in volunteers immunized with 100 [micro]g ProC6C-AlOH with Matrix-M, and 13 of 20 (65%) individuals in the group showed greater than 80% transmission-reducing activity (TRA) when evaluated in the standard membrane feeding assay at 15 mg/mL IgG. In contrast, R0.6C induced sporadic TRA. CONCLUSION. All formulations were safe and well tolerated in a malaria-endemic area of Africa in healthy adults. The ProC6C-AlOH/ Matrix-M vaccine elicited the highest levels of functional antibodies, meriting further investigation. TRIAL REGISTRATION. Pan-African Clinical Trials Registry (https://pactr.samrc.ac.za) PACTR202201848463189. FUNDING. The study was funded by the European and Developing Countries Clinical Trials Partnership (grant RIA2018SV-2311)., Introduction Plasmodium falciparum malaria is transmitted by mosquitoes of the genus Anopheles. During a blood meal from an infected person, the female mosquito ingests sexual-stage parasites, which fertilize in the [...]

Published
2024
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2. Background malaria incidence and parasitemia during the three-dose RTS,S/AS01 vaccination series do not reduce magnitude of antibody response nor efficacy against the first case of malaria

Author

Bell, Griffin J, Gyaase, Stephaney, Goel, Varun, Adu, Bright, Mensah, Benedicta, Essone, Paulin, Dosoo, David, Osei, Musah, Niare, Karamoko, Wiru, Kenneth, Brandt, Katerina, Emch, Michael, Ghansah, Anita, Asante, Kwaku Poku, Mvalo, Tisungane, Agnandji, Selidji Todagbe, Juliano, Jonathan J, and Bailey, Jeffrey A

Published
2023
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5. SARS-CoV-2 Molecular Evolutionary Dynamics in the Greater Accra Region, Ghana

Author

Adu, Bright, Bonney, Joseph H.K., Egyir, Beverly, Otchere, Isaac Darko, Asare, Prince, Dennis, Francis E., Bonney, Evelyn Yayra, Akuffo, Richard, Asante, Ivy A., Obodai, Evangeline, Kumordjie, Selassie, Appiah-Kubi, Joyce, Mohktar, Quaneeta, Frempong, Hilda Opoku, Asiedu-Bekoe, Franklin, Adusei-Poku, Mildred A., Aboagye, James O., Agbodzi, Bright, Yeboah, Clara, Agbenyo, Seyram B., Uche, Peace O., Attiku, Keren O., Sekyere, Bernice Twenewaa, Laryea, Dennis, Buabeng, Kwame, Lamptey, Helena, Ghansah, Anita, Yeboah-Manu, Dorothy, Anang, Abraham K., Ampofo, William K., Kyei, George B., and Odoom, John K.

Subjects
Accra, Ghana -- Health aspects, Molecular dynamics -- Research, Epidemics -- Distribution -- Risk factors -- Ghana, Disease transmission -- Research, Virus research, Company distribution practices, Health
Abstract

The emergence of SARS-CoV-2 variants with superior transmissibility or immune evasion advantages may cause outbreaks and dominate transmission in a population (1). Thus, keeping track of the dynamics of variant [...]

Published
2023

6. A pan-African pathogen genomics data sharing platform to support disease outbreaks

Author

Christoffels, Alan, Mboowa, Gerald, van Heusden, Peter, Makhubela, Sello, Githinji, George, Mwangi, Sarah, Onywera, Harris, Nnaemeka, Ndodo, Amoako, Daniel Gyamfi, Olawoye, Idowu, Diallo, Amadou, Mbala-Kingebeni, Placide, Oyola, Samuel O., Adu, Bright, Mvelase, Christopher, Ondoa, Pascale, Dratibi, Fred Athanasius, Sow, Abdourahmane, Gumede, Nicksy, Tessema, Sofonias K., Ouma, Ahmed Ogwell, and Tebeje, Yenew Kebede

Published
2023
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8. Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data

Author

Badr, Hamada S, Colston, Josh M, Nguyen, Nhat-Lan H, Chen, Yen Ting, Burnett, Eleanor, Ali, Syed Asad, Rayamajhi, Ajit, Satter, Syed M, Van Trang, Nguyen, Eibach, Daniel, Krumkamp, Ralf, May, Jürgen, Adegnika, Ayola Akim, Manouana, Gédéon Prince, Kremsner, Peter Gottfried, Chilengi, Roma, Hatyoka, Luiza, Debes, Amanda K, Ateudjieu, Jerome, Faruque, Abu S G, Hossain, M Jahangir, Kanungo, Suman, Kotloff, Karen L, Mandomando, Inácio, Nisar, M Imran, Omore, Richard, Sow, Samba O, Zaidi, Anita K M, Lambrecht, Nathalie, Adu, Bright, Page, Nicola, Platts-Mills, James A, Mavacala Freitas, Cesar, Pelkonen, Tuula, Ashorn, Per, Maleta, Kenneth, Ahmed, Tahmeed, Bessong, Pascal, Bhutta, Zulfiqar A, Mason, Carl, Mduma, Estomih, Olortegui, Maribel P, Peñataro Yori, Pablo, Lima, Aldo A M, Kang, Gagandeep, Humphrey, Jean, Ntozini, Robert, Prendergast, Andrew J, Okada, Kazuhisa, Wongboot, Warawan, Langeland, Nina, Moyo, Sabrina J, Gaensbauer, James, Melgar, Mario, Freeman, Matthew, Chard, Anna N, Thongpaseuth, Vonethalom, Houpt, Eric, Zaitchik, Benjamin F, and Kosek, Margaret N

Published
2023
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13. COVID-19 in patients presenting with malaria-like symptoms at a primary healthcare facility in Accra, Ghana

Author

Asamoah, Issabella, primary, Adusei-Poku, Mildred, additional, Vandyck-Sey, Priscilla, additional, Steele-Dadzie, Allen, additional, Kuffour, Atta Senior, additional, Turkson, Albert, additional, Asante, Ivy Asantewaa, additional, Addo-Osafo, Kantanka, additional, Mohktar, Quaneeta, additional, Adu, Bright, additional, Afrane, Yaw A., additional, and Sagoe, Kwamena W. C., additional

Published
2024
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14. A randomized first-in-human Phase 1 trial of differentially adjuvanted Pfs48/45 malaria vaccines in Burkinabé adults

Author

Tiono, B. Alfred, primary, Plieskatt, Jordan L., additional, Ouedraogo, Alphonse, additional, Soulama, Ben Idriss, additional, Miura, Kazutoyo, additional, Bougouma, Edith C., additional, Naghizadeh, Mohammad, additional, Barry, Aissata, additional, Yaro, Jean Baptiste B., additional, Ezinmegnon, Sem, additional, Henry, Noelie B., additional, Ofori, Ebenezer, additional, Adu, Bright, additional, Singh, Susheel K., additional, Konkobo, Augustin, additional, Lövgren Bengtsson, Karin, additional, Diarra, Amidou, additional, Carnrot, Cecilia, additional, Reimer, Jenny M., additional, Ouedraogo, Amidou Z., additional, Tienta, Moussa, additional, Long, Carole A., additional, Nebie, Issa N., additional, Sagara, Issaka, additional, Sirima, Sodiomon B., additional, and Theisen, Michael, additional

Published
2024
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16. Antibody response to malaria vaccine candidates in pregnant women with Plasmodium falciparum and Schistosoma haematobium infections.

Author

Frempong, Naa Adjeley, Mama, Atikatou, Adu, Bright, Kusi, Kwadwo Asamoah, Ofori, Michael F., Ahiabor, Charity, Anyan, William K., Debrah, Alex Yaw, Anang, Abraham A., Ndam, Nicaise T., and Courtin, David

Subjects
SCHISTOSOMA haematobium, ANTIBODY formation, MALARIA vaccines, PREGNANT women, PLASMODIUM falciparum
Abstract

Malaria in pregnancy has severe consequences for the mother and foetus. Antibody response to specific malaria vaccine candidates (MVC) has been associated with a decreased risk of clinical malaria and its outcomes. We studied Plasmodium falciparum (Pf) and Schistosoma haematobium (Sh) infections and factors that could influence antibody responses to MVC in pregnant women. A total of 337 pregnant women receiving antenatal care (ANC) and 139 for delivery participated in this study. Pf infection was detected by qPCR and Sh infection using urine filtration method. Antibody levels against CSP, AMA‐1, GLURP‐R0, VAR2CSA and Pfs48/45 MVC were quantified by ELISA. Multivariable linear regression models identified factors associated with the modulation of antibody responses. The prevalence of Pf and Sh infections was 27% and 4% at ANC and 7% and 4% at delivery. Pf infection, residing in Adidome and multigravidae were positively associated with specific IgG response to CSP, AMA‐1, GLURP‐R0 and VAR2CSA. ITN use and IPTp were negatively associated with specific IgG response to GLURP‐R0 and Pfs48/45. There was no association between Sh infection and antibody response to MVC at ANC or delivery. Pf infections in pregnant women were positively associated with antibody response to CSP, GLURP‐R0 and AMA‐1. Antibody response to GLURP‐R0 and Pfs48/45 was low for IPTp and ITN users. This could indicate a lower exposure to Pf infection and low malaria prevalence observed at delivery. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Malaria, Urogenital Schistosomiasis, and Anaemia in Pregnant Ghanaian Women

Author

Frempong, Naa Adjeley, primary, Ahiabor, Charity, additional, Anyan, William K., additional, Mama, Atikatou, additional, Kusi, Kwadwo Asamoah, additional, Ofori, Michael F., additional, Adu, Bright, additional, Debrah, Alex Yaw, additional, Anang, Abraham K., additional, Ndam, Nicaise T., additional, and Courtin, David, additional

Published
2023
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25. Malaria Transmission Intensity and Parasitemia during the Three-Dose RTS,S/AS01 Vaccination Series do not Reduce Magnitude of Antibody Response nor Efficacy Against the First Case of Malaria

Author

Bell, Griffin J, primary, Gyaase, Stephaney, additional, Goel, Varun, additional, Adu, Bright, additional, Mensah, Benedicta, additional, Essone, Paulin, additional, Dosoo, David, additional, Osei, Musah, additional, Niare, Karamoko, additional, Wiru, Kenneth, additional, Brandt, Katerina, additional, Emch, Michael, additional, Ghansah, Anita, additional, Asante, Kwaku Poku, additional, Mvalo, Tisungane, additional, Agnandji, Selidhi Todagbe, additional, Juliano, Jonathan J, additional, and Bailey, Jeffrey A, additional

Published
2023
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26. Antenatal care attendance, intermittent preventive treatment in pregnancy and knowledge on malaria: A cross sectional study in a government and a private district Hospitals

Author

Ahiabor, Charity, primary, Courtin, David, additional, Anyan, William, additional, Mama, Atikatou, additional, Frempong, Naa Adjeley, additional, Kusi, Kwadwo A, additional, Ofori, Michael F, additional, Adu, Bright, additional, Lawson, Bernard W, additional, Anang, Abraham K, additional, and Ndam, Nicaise T, additional

Published
2023
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27. High opsonic phagocytosis activity and growth inhibition of merozoites are associated with RON4 antibody levels and protect against febrile malaria in Ghanaian children

Author

Kyei-Baafour, Eric, primary, Kusi, Kwadwo Asamoah, additional, Arthur, Fareed K.N., additional, Tiendrebeogo, Regis W., additional, Owusu-Yeboa, Eunice, additional, Singh, Susheel K., additional, Friedrich, Sarah, additional, Gerds, Thomas A., additional, Dodoo, Daniel, additional, Theisen, Michael, additional, and Adu, Bright, additional

Published
2023
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29. Prevalence of, and knowledge about intestinal helminths among pregnant women at Adidome and Battor district Hospitals

Author

Ahiabor, Charity, primary, Frempong, Naa Adjeley, additional, Mama, Atikatou, additional, Kusi, Kwadwo A., additional, Anyan, William, additional, Ofori, Michael F., additional, Adu, Bright, additional, Ashong, Yvonne, additional, Lawson, Bernard W., additional, Anang, Abraham K., additional, Ndam, Nicaise T., additional, and Courtin, David, additional

Published
2023
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30. Antibiotic Profiles and Draft Genome Sequences of Kerstersia gyiorum, Providencia stuartii, Providencia vermicola, and Alcaligenes faecalis Strains Recovered from Soft Tissue Biopsy Samples in Ghana

Author

Egyir, Beverly, primary, Owusu, Felicia, additional, Owusu-Nyantakyi, Christian, additional, Amuasi, Grebstad Rabbi, additional, Boateng, William, additional, Kodom, Sarkodie, additional, Mohktar, Quaneeta, additional, Nilsson, Pernille, additional, Adu, Bright, additional, and Hendriksen, Rene S., additional

Published
2023
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32. Fc Gamma Receptor IIIB NA1/NA2/SH Polymorphisms Are Associated with Malaria Susceptibility and Antibody Levels to P. falciparum Merozoite Antigens in Beninese Children

Author

Fall, Abdou Khadre Dit Jadir, primary, Courtin, David, additional, Adamou, Rafiou, additional, Edslev, Sofie, additional, Hansen, Anita, additional, Domingo, Nadia, additional, Christiansen, Michael, additional, Adu, Bright, additional, Milet, Jacqueline, additional, Garcia, André, additional, Theisen, Michael, additional, Migot-Nabias, Florence, additional, and Dechavanne, Célia, additional

Published
2022
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33. Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data

Author

Badr, Hamada S., primary, Colston, Josh M., additional, Nguyen, Nhat-Lan H., additional, Chen, Yen Ting, additional, Ali, Syed Asad, additional, Rayamajhi, Ajit, additional, Satter, Syed M., additional, Van Trang, Nguyen, additional, Eibach, Daniel, additional, Krumkamp, Ralf, additional, May, Jürgen, additional, Adegnika, Ayola Akim, additional, Prince Manouana, Gédéon, additional, Kremsner, Peter Gottfried, additional, Chilengi, Roma, additional, Hatyoka, Luiza, additional, Debes, Amanda K., additional, Ateudjieu, Jerome, additional, Faruque, Abu S. G., additional, Hossain, M. Jahangir, additional, Kanungo, Suman, additional, Kotloff, Karen L., additional, Mandomando, Inácio, additional, Nisar, M. Imran, additional, Omore, Richard, additional, Sow, Samba O., additional, Zaidi, Anita K. M., additional, Lambrecht, Nathalie, additional, Adu, Bright, additional, Page, Nicola, additional, Platts-Mills, James A., additional, Freitas, Cesar Mavacala, additional, Pelkonen, Tuula, additional, Ashorn, Per, additional, Maleta, Kenneth, additional, Ahmed, Tahmeed, additional, Bessong, Pascal, additional, Bhutta, Zulfiqar A., additional, Mason, Carl, additional, Mduma, Estomih, additional, Olortegui, Maribel P., additional, Yori, Pablo Peñataro, additional, Lima, Aldo A. M., additional, Kang, Gagandeep, additional, Humphrey, Jean, additional, Ntozini, Robert, additional, Prendergast, Andrew J., additional, Okada, Kazuhisa, additional, Wongboot, Warawan, additional, Langeland, Nina, additional, Moyo, Sabrina J., additional, Gaensbauer, James, additional, Melgar, Mario, additional, Freeman, Matthew, additional, Chard, Anna N., additional, Thongpaseuth, Vonethalom, additional, Houpt, Eric, additional, Zaitchik, Benjamin F., additional, and Kosek, Margaret N., additional

Published
2022
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34. Malaria Transmission Intensity Likely Modifies RTS, S/AS01 Efficacy Due to a Rebound Effect in Ghana, Malawi, and Gabon

Author

Bell, Griffin J, primary, Goel, Varun, additional, Essone, Paulin, additional, Dosoo, David, additional, Adu, Bright, additional, Mensah, Benedicta Ayiedu, additional, Gyaase, Stephaney, additional, Wiru, Kenneth, additional, Mougeni, Fabrice, additional, Osei, Musah, additional, Minsoko, Pamela, additional, Sinai, Cyrus, additional, Niaré, Karamoko, additional, Juliano, Jonathan J, additional, Hudgens, Michael, additional, Ghansah, Anita, additional, Kamthunzi, Portia, additional, Mvalo, Tisungane, additional, Agnandji, Selidji Todagbe, additional, Bailey, Jeffrey A, additional, Asante, Kwaku Poku, additional, and Emch, Michael, additional

Published
2022
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40. Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens

Author

Sakyi, Samuel A., primary, Wilson, Michael D., additional, Adu, Bright, additional, Opoku, Stephen, additional, Brewoo, Antwi, additional, Larbi, Amma, additional, Baafour, Emmanuel K., additional, Tchum, Samuel K., additional, Saahene, Roland O., additional, Aniagyei, Wilfred, additional, Sewor, Christian, additional, Courtin, David, additional, Cappello, Michael, additional, Gyan, Ben, additional, and Amoani, Benjamin, additional

Published
2022
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42. Effect of Iron Fortification on Anaemia and Risk of Malaria among Ghanaian Pre-School Children with Haemoglobinopathies and Different ABO Blood Groups

Author

Tchum, Samuel Kofi, primary, Sakyi, Samuel Asamoah, additional, Arthur, Fareed, additional, Adu, Bright, additional, Abubakar, Latifatu Alhassan, additional, Oppong, Felix Boakye, additional, Dzabeng, Francis, additional, Amoani, Benjamin, additional, Gyan, Thomas, additional, and Asante, Kwaku Poku, additional

Published
2022
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43. The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

Author

Tegally, Houriiyah, primary, San, James E., additional, Cotten, Matthew, additional, Tegomoh, Bryan, additional, Mboowa, Gerald, additional, Martin, Darren P., additional, Baxter, Cheryl, additional, Moir, Monika, additional, Lambisia, Arnold, additional, Diallo, Amadou, additional, Amoako, Daniel G., additional, Diagne, Moussa M., additional, Sisay, Abay, additional, Zekri, Abdel-Rahman N., additional, Barakat, Abdelhamid, additional, Gueye, Abdou Salam, additional, Sangare, Abdoul K., additional, Ouedraogo, Abdoul-Salam, additional, Sow, Abdourahmane, additional, Musa, Abdualmoniem O., additional, Sesay, Abdul K., additional, Lagare, Adamou, additional, Kemi, Adedotun-Sulaiman, additional, Abar, Aden Elmi, additional, Johnson, Adeniji A., additional, Fowotade, Adeola, additional, Olubusuyi, Adewumi M., additional, Oluwapelumi, Adeyemi O., additional, Amuri, Adrienne A., additional, Juru, Agnes, additional, Ramadan, Ahmad Mabrouk, additional, Kandeil, Ahmed, additional, Mostafa, Ahmed, additional, Rebai, Ahmed, additional, Sayed, Ahmed, additional, Kazeem, Akano, additional, Balde, Aladje, additional, Christoffels, Alan, additional, Trotter, Alexander J., additional, Campbell, Allan, additional, Keita, Alpha Kabinet, additional, Kone, Amadou, additional, Bouzid, Amal, additional, Souissi, Amal, additional, Agweyu, Ambrose, additional, Gutierrez, Ana V., additional, Page, Andrew J., additional, Yadouleton, Anges, additional, Vinze, Anika, additional, Happi, Anise N., additional, Chouikha, Anissa, additional, Iranzadeh, Arash, additional, Maharaj, Arisha, additional, Batchi-Bouyou, Armel Landry, additional, Ismail, Arshad, additional, Sylverken, Augustina, additional, Goba, Augustine, additional, Femi, Ayoade, additional, Sijuwola, Ayotunde Elijah, additional, Ibrahimi, Azeddine, additional, Marycelin, Baba, additional, Salako, Babatunde Lawal, additional, Oderinde, Bamidele S., additional, Bolajoko, Bankole, additional, Dhaala, Beatrice, additional, Herring, Belinda L., additional, Tsofa, Benjamin, additional, Mvula, Bernard, additional, Njanpop-Lafourcade, Berthe-Marie, additional, Marondera, Blessing T., additional, Khaireh, Bouh Abdi, additional, Kouriba, Bourema, additional, Adu, Bright, additional, Pool, Brigitte, additional, McInnis, Bronwyn, additional, Brook, Cara, additional, Williamson, Carolyn, additional, Anscombe, Catherine, additional, Pratt, Catherine B., additional, Scheepers, Cathrine, additional, Akoua-Koffi, Chantal G., additional, Agoti, Charles N., additional, Loucoubar, Cheikh, additional, Onwuamah, Chika Kingsley, additional, Ihekweazu, Chikwe, additional, Malaka, Christian Noël, additional, Peyrefitte, Christophe, additional, Omoruyi, Chukwuma Ewean, additional, Rafaï, Clotaire Donatien, additional, Morang’a, Collins M., additional, Nokes, D. James, additional, Lule, Daniel Bugembe, additional, Bridges, Daniel J., additional, Mukadi-Bamuleka, Daniel, additional, Park, Danny, additional, Baker, David, additional, Doolabh, Deelan, additional, Ssemwanga, Deogratius, additional, Tshiabuila, Derek, additional, Bassirou, Diarra, additional, Amuzu, Dominic S.Y., additional, Goedhals, Dominique, additional, Grant, Donald S., additional, Omuoyo, Donwilliams O., additional, Maruapula, Dorcas, additional, Wanjohi, Dorcas Waruguru, additional, Foster-Nyarko, Ebenezer, additional, Lusamaki, Eddy K., additional, Simulundu, Edgar, additional, Ong’era, Edidah M., additional, Ngabana, Edith N., additional, Abworo, Edward O., additional, Otieno, Edward, additional, Shumba, Edwin, additional, Barasa, Edwine, additional, Ahmed, El Bara, additional, Kampira, Elizabeth, additional, Fahime, Elmostafa El, additional, Lokilo, Emmanuel, additional, Mukantwari, Enatha, additional, Cyril, Erameh, additional, Philomena, Eromon, additional, Belarbi, Essia, additional, Simon-Loriere, Etienne, additional, Anoh, Etilé A., additional, Leendertz, Fabian, additional, Taweh, Fahn M., additional, Wasfi, Fares, additional, Abdelmoula, Fatma, additional, Takawira, Faustinos T., additional, Derrar, Fawzi, additional, Ajogbasile, Fehintola V, additional, Treurnicht, Florette, additional, Onikepe, Folarin, additional, Ntoumi, Francine, additional, Muyembe, Francisca M., additional, Ngiambudulu, Francisco, additional, Zongo Ragomzingba, Frank Edgard, additional, Dratibi, Fred Athanasius, additional, Iyanu, Fred-Akintunwa, additional, Mbunsu, Gabriel K., additional, Thilliez, Gaetan, additional, Kay, Gemma L., additional, Akpede, George O., additional, George, Uwem E., additional, van Zyl, Gert, additional, Awandare, Gordon A., additional, Schubert, Grit, additional, Maphalala, Gugu P., additional, Ranaivoson, Hafaliana C., additional, Lemriss, Hajar, additional, Omunakwe, Hannah E, additional, Onywera, Harris, additional, Abe, Haruka, additional, Karray, Hela, additional, Nansumba, Hellen, additional, Triki, Henda, additional, Adje Kadjo, Herve Albéric, additional, Elgahzaly, Hesham, additional, Gumbo, Hlanai, additional, mathieu, Hota, additional, Kavunga-Membo, Hugo, additional, Smeti, Ibtihel, additional, Olawoye, Idowu B., additional, Adetifa, Ifedayo, additional, Odia, Ikponmwosa, additional, Boubaker, Ilhem Boutiba-Ben, additional, Ssewanyana, Isaac, additional, Wurie, Isatta, additional, Konstantinus, Iyaloo S, additional, Afiwa Halatoko, Jacqueline Wemboo, additional, Ayei, James, additional, Sonoo, Janaki, additional, Lekana-Douki, Jean Bernard, additional, Makangara, Jean-Claude C., additional, Tamfum, Jean-Jacques M., additional, Heraud, Jean-Michel, additional, Shaffer, Jeffrey G., additional, Giandhari, Jennifer, additional, Musyoki, Jennifer, additional, Uwanibe, Jessica N., additional, Bhiman, Jinal N., additional, Yasuda, Jiro, additional, Morais, Joana, additional, Mends, Joana Q., additional, Kiconco, Jocelyn, additional, Sandi, John Demby, additional, Huddleston, John, additional, Odoom, John Kofi, additional, Morobe, John M., additional, Gyapong, John O., additional, Kayiwa, John T., additional, Okolie, Johnson C., additional, Xavier, Joicymara Santos, additional, Gyamfi, Jones, additional, Kofi Bonney, Joseph Humphrey, additional, Nyandwi, Joseph, additional, Everatt, Josie, additional, Farah, Jouali, additional, Nakaseegu, Joweria, additional, Ngoi, Joyce M., additional, Namulondo, Joyce, additional, Oguzie, Judith U., additional, Andeko, Julia C., additional, Lutwama, Julius J., additional, O’Grady, Justin, additional, Siddle, Katherine J, additional, Victoir, Kathleen, additional, Adeyemi, Kayode T., additional, Tumedi, Kefentse A., additional, Carvalho, Kevin Sanders, additional, Mohammed, Khadija Said, additional, Musonda, Kunda G., additional, Duedu, Kwabena O., additional, Belyamani, Lahcen, additional, Fki-Berrajah, Lamia, additional, Singh, Lavanya, additional, Biscornet, Leon, additional, de Oliveira Martins, Leonardo, additional, Chabuka, Lucious, additional, Olubayo, Luicer, additional, Deng, Lul Lojok, additional, Ochola-Oyier, Lynette Isabella, additional, Mine, Madisa, additional, Ramuth, Magalutcheemee, additional, Mastouri, Maha, additional, ElHefnawi, Mahmoud, additional, Mbanne, Maimouna, additional, Matsheka, Maitshwarelo I., additional, Kebabonye, Malebogo, additional, Diop, Mamadou, additional, Momoh, Mambu, additional, Lima Mendonça, Maria da Luz, additional, Venter, Marietjie, additional, Paye, Marietou F, additional, Faye, Martin, additional, Nyaga, Martin M., additional, Mareka, Mathabo, additional, Damaris, Matoke-Muhia, additional, Mburu, Maureen W., additional, Mpina, Maximillian, additional, Claujens Chastel, Mfoutou Mapanguy, additional, Owusu, Michael, additional, Wiley, Michael R., additional, Tatfeng, Mirabeau Youtchou, additional, Ayekaba, Mitoha Ondo’o, additional, Abouelhoda, Mohamed, additional, Beloufa, Mohamed 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Published
2022
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48. SARS-CoV-2 detection among international air travellers to Ghana during mandatory quarantine

Author

Adu, Bright, K. H. Bonney, Joseph, K. Odoom, John, Y. A. Bonney, Evelyn, Obodai, Evangeline, A. Asante, Ivy, Aboagye, James, A. Adusei-Poku, Mildred, Lartey, Lawrence, K. Asiedu, Ernest, K. Ampofo, William, and B. Kyei, George

Subjects
body regions, SARS-CoV-2, COVID-19, mandatory quarantine, Ghana, international travellers, testing
Abstract

Objectives: To determine the prevalence of SARS-CoV-2 detection among international travellers to Ghana during mandatory quarantine.Design: A retrospective cross-sectional study.Setting: Air travellers to Ghana on 21st and 22nd March 2020.Participants: On 21st and 22nd March 2020, a total of 1,030 returning international travellers were mandatorily quarantined in 15 different hotels in Accra and tested for SARS-CoV-2. All of these persons were included in the study.Main outcome measure: Positivity for SARS-CoV-2 by polymerase chain reaction.Results: The initial testing at the beginning of quarantine found 79 (7.7%) individuals to be positive for SARS-CoV-2. In the exit screening after 12 to 13 days of quarantine, it was discovered that 26 of those who tested negative for SARS-CoV-2 in the initial screening subsequently tested positive.Conclusions: Ghana likely averted an early community spread of COVID-19 through the proactive approach to quarantine international travellers during the early phase of the pandemic.

Published
2021

49. Data management during COVID-19 outbreak response in Ghana: a reference laboratory perspective on key issues and measures

Author

Obodai, Evangeline, B. Kyei, George, Aboagye, James, Y. Bonney, Evelyn, A. Asante, Ivy, K. H. Bonney, Joseph, Adusei-Poku, Mildred, Lamptey, Helena, Adu, Bright, Kenu, Ernest, A. Koram, Kwadwo, K. Ampofo, William, and K. Odoom, John

Subjects
surveillance, pandemic, COVID-19, data management, laboratory diagnosis
Abstract

The COVID-19 pandemic caused by SARS-CoV-2 is an important subject for global health. Ghana experienced lowmoderate transmission of the disease when the first case was detected in March 12, 2020 until the middle of July when the number of cases begun to drop. By August 24, 2020, the country's total number of confirmed cases stood at 43,622, with 263 deaths. By the same time, the Noguchi Memorial Institute for Medical Research (NMIMR) of the University of Ghana, the primary testing centre for COVID-19, had tested 285,501 with 28,878 confirmed cases. Due to database gaps, there were initial challenges with timely reporting and feedback to stakeholders during the peak surveillance period. The gaps resulted from mismatches between samples and their accompanying case investigation forms, samples without case investigation forms and vice versa, huge data entry requirements, and delayed test results. However, a revamp in data management procedures, and systems helped to improve the turnaround time for reporting results to all interested parties and partners. Additionally, inconsistencies such as multiple entries and discrepant patient-sample information were resolved by introducing a barcoding electronic capture system. Here, we describe the main challenges with COVID-19 data management and analysis in the laboratory and recommend measures for improvement.

Published
2021

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