1. Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis
- Author
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Ilaria Simonelli, Akishige Kanazawa, Chung Yip Chan, Brian K. P. Goh, Carlo Sposito, Ho Seong Han, Tan To Cheung, Matteo Cimino, Shogo Tanaka, Gregory C. Wilson, Kazuharu Igarashi, Giuseppe Maria Ettorre, Yutaka Takeda, Zenichi Morise, Guido Torzilli, Hironori Kaneko, Roberto Troisi, Sungho Kim, Vincenzo Mazzaferro, Giammauro Berardi, Go Wakabayashi, Valentina Panetta, Shoji Kubo, David A. Geller, Berardi, G., Morise, Z., Sposito, C., Igarashi, K., Panetta, V., Simonelli, I., Kim, S., Goh, B. K. P., Kubo, S., Tanaka, S., Takeda, Y., Ettorre, G. M., Wilson, G. C., Cimino, M., Chan, C. -Y., Torzilli, G., Cheung, T. T., Kaneko, H., Mazzaferro, V., Geller, D. A., Han, H. -S., Kanazawa, A., Wakabayashi, G., and Troisi, R. I.
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Cirrhosis ,Surgical stress ,Liver resection ,Hepatology ,Hepatocellular carcinoma ,business.industry ,Advanced cirrhosis ,Child-Pugh B ,Patient characteristics ,Nomogram ,medicine.disease ,Surgery ,Resection ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine ,Advanced liver cirrhosi ,030211 gastroenterology & hepatology ,Liver function ,business - Abstract
Background & Aims: Treatment allocation in patients with hepatocellular carcinoma (HCC) on a background of Child-Pugh B (CP-B) cirrhosis is controversial. Liver resection has been proposed in small series with acceptable outcomes, but data are limited. The aim of this study was to evaluate the outcomes of patients undergoing liver resection for HCC in CP-B cirrhosis, focusing on the surgical risks and survival. Methods: Patients were retrospectively pooled from 14 international referral centers from 2002 to 2017. Postoperative and oncological outcomes were investigated. Prediction models for surgical risks, disease-free survival and overall survival were constructed. Results: A total of 253 patients were included, of whom 57.3% of patients had a preoperative platelet count
- Published
- 2020
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