1. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a position statement from an international expert group
- Author
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Mohty, M., Malard, F., Abecasis, M., Aerts, E., Alaskar, A.S., Aljurf, M., Arat, M., Bader, P., Baron, F., Basak, G., Bazarbachi, A., Blaise, D., Ciceri, F., Corbacioglu, S., Dalle, J.H., Dignan, F., Fukuda, T., Huynh, A., Kuball, J., Lachance, S., Lazarus, H., Masszi, T., Michallet, M., Nagler, A., NiChonghaile, M., Okamoto, S., Pagliuca, A., Peters, C., Petersen, F.B., Richardson, P.G., Ruutu, T., Saber, W., Savani, B.N., Soiffer, R., Styczynski, J., Wallhult, E., Yakoub-Agha, I., Duarte, R.F., Carreras, Enric, Universitat Autònoma de Barcelona, HUS Comprehensive Cancer Center, Clinicum, Hematologian yksikkö, Mohty, M., Malard, F., Abecasis, M., Aerts, E., Alaskar, A. S., Aljurf, M., Arat, M., Bader, P., Baron, F., Basak, G., Bazarbachi, A., Blaise, D., Ciceri, F., Corbacioglu, S., Dalle, J. -H., Dignan, F., Fukuda, T., Huynh, A., Kuball, J., Lachance, S., Lazarus, H., Masszi, T., Michallet, M., Nagler, A., Nichonghaile, M., Okamoto, S., Pagliuca, A., Peters, C., Petersen, F. B., Richardson, P. G., Ruutu, T., Saber, W., Savani, B. N., Soiffer, R., Styczynski, J., Wallhult, E., Yakoub-Agha, I., Duarte, R. F., Carreras, E., and UAM. Departamento de Medicina
- Subjects
Feature ,Adult ,medicine.medical_specialty ,HEPATIC VENOOCCLUSIVE DISEASE ,HAPLOIDENTICAL DONOR TRANSPLANTATION ,Medicina ,3122 Cancers ,Hepatic Veno-Occlusive Disease ,Disease ,Hematopoietic cell transplantation (HCT) ,Therapeutics ,PERIPHERAL-BLOOD ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Polydeoxyribonucleotides ,Randomized controlled trial ,law ,medicine ,Humans ,Vascular Diseases ,Intensive care medicine ,Transplantation ,Adult patients ,business.industry ,Mortality rate ,Consensus guideline ,Hematopoietic Stem Cell Transplantation ,REGIMEN-RELATED TOXICITIES ,STEM-CELL TRANSPLANTATION ,Hematology ,Expert group ,BONE-MARROW-TRANSPLANTATION ,PD-1 BLOCKADE ,EUROPEAN-SOCIETY ,RANDOMIZED-TRIAL ,3. Good health ,URSODEOXYCHOLIC ACID ,030220 oncology & carcinogenesis ,Veno-occlusive disease (SOS/VOD ,Veno-Occlusive Disease ,Complication ,business ,Haematological diseases ,030215 immunology - Abstract
Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). While SOS/VOD may resolve within a few weeks in the majority of patients with mild-to-moderate disease, the most severe forms result in multiorgan dysfunction and are associated with a high mortality rate (>80%). Therefore, careful surveillance may allow early detection of SOS/VOD, particularly as the licensed available drug is proven to be effective and reduce mortality. The aim of this work is to propose an international consensus guideline for the treatment and prevention of SOS/VOD in adult patients, on behalf of an international expert group, This work was made possible thanks to the support of the Association for Training, Education, Research, in Hematology, Immunology and Transplantation (ATHERIT), which received an unrestricted educational grant from JAZZ pharmaceuticals
- Published
- 2021