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11. A Comprehensive Review and Androgen Deprivation Therapy and Its Impact on Alzheimer’s Disease Risk in Older Men with Prostate Cancer

Author

Singh,Manisha, Agarwal,Vinayak, Pancham,Pranav, Jindal,Divya, Agarwal,Shriya, Rai,Sachchida, Singh,Santosh, Gupta,Vivek, Singh,Manisha, Agarwal,Vinayak, Pancham,Pranav, Jindal,Divya, Agarwal,Shriya, Rai,Sachchida, Singh,Santosh, and Gupta,Vivek

Abstract

Manisha Singh,1– 3,* Vinayak Agarwal,3,4,* Pranav Pancham,3,5 Divya Jindal,3,6 Shriya Agarwal,3,7 Sachchida Nand Rai,8 Santosh Kumar Singh,8 Vivek Gupta9 1Faculty of Health, Graduate School of Health, University of Technology Sydney, Sydney, Australia; 2ARCCIM, School of Public Health, Faculty of Health, University of Technology Sydney, Sydney, Australia; 3Department of Biotechnology, Jaypee Institute of Information Technology (JIIT) Noida, Noida, Uttar Pradesh, India; 4School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia; 5School of Medicine, Western Sydney University, Sydney, Australia; 6Indian Institute of Technology Bombay Monash Research Academy, Mumbai, India; 7Department of Molecular Science, School of Natural Sciences, Macquarie University, Sydney, Australia; 8Centre of Experimental Medicine and Surgery (CEMS), Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, 221005, India; 9Macquarie Medical School, Macquarie University, Sydney, Australia*These authors contributed equally to this workCorrespondence: Manisha Singh, Faculty of Health, Graduate School of Health, University of Technology Sydney, Sydney, Australia, Email manishasingh1295@gmail.comAbstract: Prostate cancer (PCa) is one of the most prevalent malignancies affecting males worldwide. Despite reductions in mortality rates due to advances in early identification and treatment methods, PCa remains a major health concern. Recent research has shed light on a possible link between PCa and Alzheimer’s disease (AD), which is a significant neurological ailment that affects older males all over the world. Androgen deprivation therapy (ADT), a cornerstone therapeutic method used in conjunction with radiation and palliative care in advanced metastatic PCa cases, is critical for disease management. Evidence reveals a relationship between ADT and cognitive impairment. Hormonal manipulation may cause

Published
2024

14. A Comprehensive Review and Androgen Deprivation Therapy and Its Impact on Alzheimer's Disease Risk in Older Men with Prostate Cancer.

Author

Singh, Manisha, Agarwal, Vinayak, Pancham, Pranav, Jindal, Divya, Agarwal, Shriya, Rai, Sachchida Nand, Singh, Santosh Kumar, and Gupta, Vivek

Subjects
PROSTATE cancer, DISEASE risk factors, ANDROGEN deprivation therapy, PROSTATE cancer patients, OLDER men, ALZHEIMER'S disease
Abstract

Prostate cancer (PCa) is one of the most prevalent malignancies affecting males worldwide. Despite reductions in mortality rates due to advances in early identification and treatment methods, PCa remains a major health concern. Recent research has shed light on a possible link between PCa and Alzheimer's disease (AD), which is a significant neurological ailment that affects older males all over the world. Androgen deprivation therapy (ADT), a cornerstone therapeutic method used in conjunction with radiation and palliative care in advanced metastatic PCa cases, is critical for disease management. Evidence reveals a relationship between ADT and cognitive impairment. Hormonal manipulation may cause long-term cognitive problems through processes such as amyloid beta (Aβ) aggregation and neurofibrillary tangles (NFTs). Fluctuations in basal androgen levels can upset the delicate balance of genes that are sensitive to androgen levels, contributing to cognitive impairment. This detailed review dives into the various aspects of PCa aetiology and its relationship with cognitive decline. It investigates the discovery of particular biomarkers, as well as microRNAs (miRNAs), which play important roles in pathogenic progression. The review attempts to identify potential biomarkers associated with ADT-induced cerebral changes, including Aβ oligomer buildup, NFT formation, and tauopathy, which can contribute to early-onset dementia and cognitive impairment. Besides it further aims to provide insights into innovative diagnostic and therapeutic avenues for alleviating PCa and ADT-related cognitive sequelae by unravelling these complicated pathways and molecular mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Oxidative Stress and Natural Antioxidants: Back and Forth in the Neurological Mechanisms of Alzheimer’s Disease

Author

Mani, Shalini, primary, Dubey, Rajni, additional, Lai, I-Chun, additional, Babu, M. Arockia, additional, Tyagi, Sakshi, additional, Swargiary, Geeta, additional, Mody, Deepansh, additional, Singh, Manisha, additional, Agarwal, Shriya, additional, Iqbal, Danish, additional, Kumar, Sanjay, additional, Hamed, Munerah, additional, Sachdeva, Punya, additional, Almutary, Abdulmajeed G., additional, Albadrani, Hind Muteb, additional, Ojha, Shreesh, additional, Singh, Sandeep Kumar, additional, and Jha, Niraj Kumar, additional

Published
2023
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16. Recent Updates on Corticosteroid-Induced Neuropsychiatric Disorders and Theranostic Advancements through Gene Editing Tools

Author

Singh, Manisha, primary, Agarwal, Vinayak, additional, Jindal, Divya, additional, Pancham, Pranav, additional, Agarwal, Shriya, additional, Mani, Shalini, additional, Tiwari, Raj Kumar, additional, Das, Koushik, additional, Alghamdi, Badrah S., additional, Abujamel, Tukri S., additional, Ashraf, Ghulam Md., additional, and Jha, Saurabh Kumar, additional

Published
2023
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18. Analysis of Process and Formulation Variables on Chitosan based Losartan Potassium Nanoparticles: Preparation, Validation and in vitro Release Kinetics

Author

Singh Manisha, Rajput Rashi, Kumar Sachin, Agarwal Shriya, Sharma Aishwarya, Sharma Malvika, and Kaur Ramneek

Subjects
Losartan Potassium, Chromatography, General Chemical Engineering, Kinetics, Nanoparticle, 02 engineering and technology, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, In vitro, Chitosan, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Scientific method, 0210 nano-technology
Abstract

Background: Although many potential therapeutic compounds have been discovered and have exhibited a promising recovery, their effective delivery in the human system has always remained questionable with many pharmacological constraints in delivering them. Amidst all this, the concept of nanomedicine has always assured the potential to overcome the drug delivery complications in the present treatment methods. Losartan Potassium (LP) is indicated in the management of hypertension. Owing to its moderate bioavailability (32%) and a number of side effects due to the oral dosage forms of LP thus, nanoparticles based delivery would be beneficial. Objective: The present study is focused to develop a nanoparticle system of Losartan Potassium, an Angiotensin II receptor antagonist and a well-known promising antihypertensive drug, to conquer its limitation of bioavailability and potential adverse effects. Method: LP Loaded Polymeric Nanoparticles (LP-NPs) were developed by ionic gelation method using Chitosan (CH) and Tripolyphosphate (TPP) for cross linkage in various optimising ratios. After the successful optimisation and synthesis of LP-NPs, the optimised formulation was further characterized by Particle Size Analysis (PSA), Polydispersity Index (PDI), Zeta Potential (ZP), TEM analysis with the in vitro cytotoxicity and permeability evaluation. Results: The results showed the average size of 123.5 ± 1.23nm with polydispersibility score of 0.257 ± 0.079 and charge of -2.74 mV respectively. Further, Transmission Electron Microscopy (TEM) images showed the size range in almost conformity with DLS findings, representing the spherical and smooth morphology. In vitro drug release kinetics estimation showed sustained release routine of the drug and the cell viability studies done on Jurkat cell line displayed lesser cytotoxicity of LP-NPs (99.3 ± 2.28% and 98.17 ± 1.86%) in comparison with the LP only (85.3 ± 2.1% and 71.7 ± 1.07%) at different time periods (12 hours and 24 hours). Conclusion: The aforementioned results confirm the effective fabrication of LP-NPs and indicate that it may further, used on higher model systems to investigate the above parameters and their enhanced effectiveness in hypertension.

Published
2020

20. Neuroprotective Ability of Apocynin Loaded Nanoparticles (APO-NPs) as NADPH Oxidase (NOX)-Mediated ROS Modulator for Hydrogen Peroxide-Induced Oxidative Neuronal Injuries

Author

Singh, Manisha, primary, Agarwal, Shriya, additional, Tiwari, Raj Kumar, additional, Chanda, Silpi, additional, Singh, Kuldeep, additional, Agarwal, Prakhar, additional, Kashyap, Aishwarya, additional, Pancham, Pranav, additional, Mall, Shweta, additional, R., Rachana, additional, and Sharma, Shalini, additional

Published
2021
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29. Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms

Author

Li, Shangda, primary, Xia, Boao, additional, Javed, Bilal, additional, Hasley, William D., additional, Melendez-Davila, Adriel, additional, Liu, Matthew, additional, Kerzner, Meir, additional, Agarwal, Shriya, additional, Xiao, Qi, additional, Torre, Paola, additional, Bermudez, Jessica G., additional, Rahimi, Khosrow, additional, Kostina, Nina Yu., additional, Möller, Martin, additional, Rodriguez-Emmenegger, Cesar, additional, Klein, Michael L., additional, Percec, Virgil, additional, and Good, Matthew C., additional

Published
2020
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