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Oxidative stress has been implicated in the pathology of many diseases like Alzheimer and Parkinson. The synthetic antioxidants used to combat the associated pathologies are expensive and likely to show side effects, or even toxic. The alternative is to look for natural antioxidants from medicinal plants. The general objective of this study is to evaluate in vitro antioxidant activity of crude extracts from four plants of the pharmacopeia of the Ivory Coast. By the DPPH free radical scavenging method, we tested 8 crude extracts including 4 aqueous and 4 ethanolic to determine their antioxidant activities. The percent inhibition of DPPH representing the antioxidant activity was calculated and the concentrations necessary to scavenge 50% of the DPPH radical (IC50) were determined with the Graph pad prism software. The results obtained showed that the aqueous and ethanolic extracts of Spathodea campanulata as well as the aqueous extract of Cola gigantea var. glabrescens have a very good antioxidant activity (IC50 μg/mL). Also, the two extracts of Entada mannii and the ethanolic extract of Landolphia heudelotii have respectively a moderate antioxidant activity (100 50 μg/mL) and a low antioxidant activity (250 50 μg/mL). In addition, the ethanolic extract of Spathodea campanulata has the highest anti-radical activity (IC50 = 14.48 ± 0.102 μg/mL) and is close to that of vitamin C (IC50 = 12.92 ± 0.079 μg/mL). Keywords: Agboville, Antioxidant, Antiradical, DPPH, medicinal plants