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We estimated total mortality using catch curves based on relative return rates (RRs) of coded wire tagged lake trout (Salvelinus namaycush) in US waters of Lake Huron. RR was calculated as age-specific CPUE per million of fish stocked. Annual mortality for the late 1990s through early 2000s was estimated as 38% from the 1991–1995 year classes, with an effective age range of 5–10 years, and then was estimated as 24% for the post-2000 period from the 1996–2009 year classes. The two estimates from simple catch curve regressions based on average RR at age values were the same as from a mixed model with individual RR values from all stocking events. These two estimates were also comparable to the findings from statistical catch-at-age assessments with fundamentally different assumptions. Our approach is not constrained by the assumption that the expected recruitment is a constant over time and thus has the advantage to use multiple observations on each age from multiple cohorts. Our approach has broad applicability to aquatic ecosystems in which multiple mark-and-release events of fish stocking have been implemented.

Neurochemical biomarkers of temperament traits might differ in their nature and impact on behavior in different age groups. This review focuses on the role of specific neurochemical and endocrine systems (thyroid hormones, sex hormones, and corticosteroids) in the regulation of behavior and their contribution to the temperament traits of adolescents. The review highlights the transient and distinct roles of hormones in behavioral regulation and their likely interactions with other neurochemical systems. Discussions of taxonomies of bio-behavioral consistent patterns (temperament traits in healthy individuals and symptoms of psychiatric disorders) should therefore include consideration of age differences.

Background Cytokine measurements to support clinical laboratory and research investigations have become increasingly common in pediatrics. However, there is a paucity of accurate pediatric reference intervals (RIs) essential to the interpretation of cytokine results. To address this gap, here, we establish age- and sex-specific pediatric reference values for clinically relevant inflammatory markers including CD163, and the cytokines IL-1β, IL-6, IL-10, IL-18, TNF-α, IFN-γ, and CXCL-9. Methods Healthy children and adolescents (n = 311, 1–19 years) were recruited as part of the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) study. Multi-analyte measurements in plasma and analytical performance verification were conducted on the ProteinSimple® Ella™ automated immunoassay platform (Bio-Techne, MN, USA). Age- and sex-specific RIs were calculated based on Clinical and Laboratory Standards Institute guidelines. Additionally, 75th and 95th percentile cut-offs were determined. Results Three types of reference value distributions were observed: (a) consistent levels throughout age and sex: IL-6, and IFN-γ, (b) gradual decline in concentration with age: CD163, TNF-α, CXCL-9, and IL-10, (c) significantly higher concentrations during ages 4–14 years than earlier and later ages: IL-1β and IL-18. Reference values for CXCL-9, IL-10, and TNF-α under 8 years of age differed significantly from older children. CD163, IL-18 and IL-1β required three age partitions. CD163 demonstrated significant sex differences in ages 8–13 years. Conclusion The circulating profile of cytokines in children is complex and can vary by age and sex. This necessitates careful interpretation of test results based on age and/or sex specific RIs facilitating more accurate clinical decision making.

This study aimed to establish age-specific velocity thresholds for Under (U)14 and U16 elite youth female soccer players. Data was collected using 10Hz GPS units during 50 matches from 187 players (U14 n=89; U16 n=98). Spectral clustering identified velocity thresholds for high-speed running (HSR), very high-speed running (VHSR), and sprinting (SPR), for 699 half-match observations (U14 n=369; U16 n=330). Linear mixed modelling determined youth (U14 and U16) and age-group (U14 or U16) velocity thresholds, and compared distances covered between these and existing senior thresholds. The effect of playing position and playing half on velocity thresholds were also quantified. Youth velocity thresholds of HSR (≥3.00m·s-1), VHSR (≥4.83m·s-1), and SPR (≥5.76m·s-1) were estimated from the model. Age-group and playing position influenced velocity thresholds but playing half did not. Adoption of youth and age-group velocity thresholds resulted in greater distance covered at HSR, VHSR and SPR (p

This study analyses age-specific differences in income trends in nine European countries. Based on data from National Accounts and the European Union Statistics on Income and Living Conditions, we quantify age-specific changes in income between 2008 and 2017 and decompose these changes into employment, wages, and public transfer components. Results show that income of the younger age groups stagnated or declined in most countries since 2008, while income of the older population increased. The decomposition analysis indicates that the main drivers of the diverging trends are higher employment among the older population and a strong increase in public pensions, especially for women. Supplementary Information The online version contains supplementary material available at 10.1007/s11205-021-02838-w users.

The spatial ecology of the Eurasian Griffon Vulture (Gyps fulvus) has been a subject of scientific interest for long due to its conservation status, critical ecosystem role, gregarious lifestyle and complex foraging behavior. The trans-border Eastern Rhodope Mountain in Bulgaria and Greece holds an increasing population of the species and one of the largest on the Balkan Peninsula. We used high-frequency GPS data from 13 Griffon Vultures from this population to study their movements, home range size and its seasonal or age specific dynamics. The overall foraging home range (95% kernel) was 3,204 km2 and the core area of activity (50% kernel) was 256.5 km2. We found high seasonal variation of the home range size. Vultures were foraging over larger areas in the summer and spring but their activity was limited to four times smaller areas in winter. We found no age specific variation in the home range sizes but the non-adult vultures showed tendency to conduct exploratory movements far from the breeding colony. Our results can be used for planning conservation efforts in the areas of high importance for the species.

Objective To quantify the temporal trend of sex- and age-specific disability-adjusted life years (DALYs) for musculoskeletal (MSK) disorders by region and cause. Methods Data were collected from the Global Burden of Diseases Study 2019. The estimated annual percentage change (EAPC) by sex, age, region and cause was calculated to examine the temporal trend of the age-standardized DALYs rate (ASDR). The sociodemographic index (SDI) and risk exposures were also examined. Results Between 1990 and 2019, the global ASDR for MSK disorders remained almost stable by sex and age group but decreased among females ages 0–14 years (EAPC = −0.27). Such age and sex patterns were nearly the same by SDI, except for high SDI regions, where ASDR increased in all subgroups except those ages 15–49 years. The trend in ASDR of MSK disorders for females and males ages 50–74 and ≥75 years increased in ∼80% of countries and territories. The greatest increase was in El Salvador for males ages 15–49 years (EAPC = 1.30), followed by Nicaragua. The association between EAPC and SDI was positive in developing regions, particularly among females ages 15–49 years, and negative in developed regions. A decreasing trend in ASDR was mainly driven by the decrease in low back pain, while the increasing trend was largely due to other MSK disorders and gout across sexes and age groups. Conclusions There are great disparities in the age- and sex-specific trends in ASDR by cause on the global, regional and national levels. More differentiated prevention and management strategies are needed for MSK disorders.

The rates of serious cardiac, neurologic, and pulmonary events attributable to colonoscopy are poorly characterized, and background event rates are usually not accounted for.We performed a multistate population-based study using changepoint analysis to determine the rates and timing of serious gastrointestinal and nongastrointestinal adverse events associated with screening/surveillance colonoscopy, including analyses by age (45 to55, 55 to65, 65 to75, and ≥75 years). Among 4.5 million persons in the Ambulatory Surgery and Services Databases of California, Florida, and New York who underwent screening/surveillance colonoscopy in 2005-2015, we ascertained serious postcolonoscopy events in excess of background rates in Emergency Department (SEDD) and Inpatient Databases (SID).Most serious nongastrointestinal postcolonoscopy events were expected based on the background rate and not associated with colonoscopy itself. However, associated nongastrointestinal events predominated over gastrointestinal events at ages ≥65 years, including more myocardial infarctions plus ischemic strokes than perforations at ages ≥75 years (361 [95% confidence intervals {CI} 312-419] plus 1,279 [95% CI 1,182-1,384] vs 912 [95% CI 831-1,002] per million). At all ages, the observed-to-expected ratios for days 0-7, 0-30, and 0-60 after colonoscopy were substantially1 for gastrointestinal bleeding and perforation, but minimally1 for most nongastrointestinal complications. Risk periods ranged from 1 to 125 days depending on complication type and age. No excess postcolonoscopy in-hospital deaths were observed.Although crude counts substantially overestimate nongastrointestinal events associated with colonoscopy, nongastrointestinal complications exceed bleeding and perforation risk in older persons. The inability to ascertain modifications to antiplatelet therapy was a study limitation. Our results can inform benefit-to-risk determinations for preventive colonoscopy.

Glomerular filtration rate (GFR) varies with age, the calculation method, and the correction factor for slope-intercept overestimation. Hence, any normal reference range accompanying the results should be suitably adapted to the method used. For Nuclear Medicine Departments using a two-sample slope-intercept method, the lack of appropriate age-specific normal reference range has been a hindrance to adopting the recently updated Jodal Brochner-Mortensen (JBM) correction over other older and more widely used methods. A retrospective analysis of the routine GFR calculation and clinical reports generated locally from 2006 to 2020 was carried out. GFR was calculated with 99mTc-DTPA plasma clearance using a two-sample slope-intercept method with JBM correction. Age-specific normal range equations were developed from normal healthy subjects. Published normal reference ranges were modified with appropriate correction reversal and compared with the locally developed reference ranges. Age-specific normal GFR reference ranges for 99mTc-DTPA with slope-intercept method and JBM correction were developed and validated with current literature. Normal reference range (Mean ± 2SD) for Normalised GFR (ml min-1 (1.73m2)-1) within 95% confidence limits suitable for use with JBM correction is 100.6 ± 35.2 for children above 2 years and 102.9 - 0.00629 × (Age)2 ± 19.4 for adults. Availability of age-specific normal GFR reference ranges applicable to the target population and appropriately tailored to the calculation method and correction factor enables Nuclear Medicine Departments to update their calculation methods in line with the current literature and also facilitates accurate reporting and evaluation of the calculated GFR results.

Age-specific reference values are important in medical science to evaluate the normal ranges of subjects and to help physicians signal potential disorders as early as possible. They are applied to ...

Objective To compare the prevalence of congenital fetal anomalies or intrauterine fetal growth restriction (IUGR) diagnosed prenatally between two in-vitro fertilization (IVF) methods—fresh embryo transfer (ET) and frozen embryo transfer (FET). Materials and methods We retrospectively reviewed medical records of patients that had conceived via IVF, and had a fetal anatomical scan performed at Taiji Clinic between 2015 and 2019. The prevalence of fetal anomalies or IUGR between both IVF methods were compared. Prevalence of congenital anomalies or IUGR by maternal age and embryo transfer type were compared by means of Chi-square analysis. Using multivariate logistic regression, we investigated factors that might be associated with higher rates of fetal anomalies or IUGR, such as parity and number of embryos transferred. Results A total of 2441 cases were selected (ET: n = 627 and FET: n = 1814). There was non-significant difference in the prevalence of fetal anomalies or IUGR between ET and FET groups (6.4% vs. 5.5%, p = 0.39). However, among women younger than 34 years of age, prevalence of fetal anomalies or IUGR was significantly higher in ET group (4.6% vs. 9.9%, p = 0.03). Conclusions Our findings suggest an age-specific effect of IVF method on the rate of fetal anomalies or IUGR and may provide useful information for physicians and infertile couples to optimize their IVF treatment plans and improve birth outcomes.

The total fertility rate (TFR) in South Asia has decreased remarkably over the past three decades. The decline is projected to continue in the coming years mostly due to the significant changes occurring in age specific fertility rate (ASFR). This study aims to investigate ASFR trends and forecast the ASFR of India, Bangladesh, and Pakistan from 2020 to 2100. The ASFRs in South Asia data separated by 7 age groups with 5-year interval from 15 to 49 years between 1990 and 2019 were downloaded from the US Census Bureau’s website. Linear regression models were used to investigate ASFR patterns from data in that period and ASFR data in the years 2010-2019 of each age group were used to forecast the ASFRs in 2020 to 2100. The forecasted results show that ASFRs in India and Bangladesh in age group 15-24 years have steep declining trends whereas ASFRs in age group 25-29 in both countries and age group 45-49 years in India have gradually decreasing ASFR trends. Age group 30-44 years in Bangladesh have slightly decreasing ASFR trends. Pakistan with previously high fertility rates are experiencing gradually declining ASFRs in all age groups. In conclusion, the change in fertility in these three countries from low stable population to high population will occur within next 40 years from 2020

Introduction There is limited knowledge of the effects of blood pressure (BP) lowering on cerebral haemodynamics after transient ischaemic attack (TIA) and non-disabling stroke, particularly at older ages. We aimed to evaluate changes in transcranial Doppler (TCD) haemodynamic indices in patients undergoing early blood pressure lowering after TIA/non-disabling stroke, irrespective of age. Patients and methods Among consecutive eligible patients attending a rapid-access clinic with suspected TIA/non-disabling stroke and no evidence of extra/intracranial stenosis, hypertensive ones underwent intensive BP-lowering guided by daily home telemetric blood pressure monitoring (HBPM). Clinic-based BP, HBPM, End-tidal CO2 and bilateral middle cerebral artery (MCA) velocity on TCD were compared in the acute setting versus one-month follow-up; changes were stratified by baseline hypertension (clinic-BP≥140/90) and by age (Results In 697 patients with repeated TCD measures, mean/SD baseline systolic-BP (145.0/21.3 mmHg) was reduced by an average of 11.3/19.9 mmHg ( p < 0.0001) at one-month (133.7/17.4 mmHg), driven by patients hypertensive at baseline (systolic-BP change = −19.0/19.2 mmHg, p < 0.001; vs −0.5/15.4, p = 0.62 in normotensives). Compared with baseline, a significant change was observed at one-month only in mean/SD MCA end diastolic velocity (EDV) (0.77/7.26 cm/s, p = 0.005) and in resistance index (RI) (−0.005/0.051, p = 0.016), driven by hypertensive patients (mean/SD EDV change: 1.145/6.96 cm/s p = 0.001, RI change −0.007/0.06, p = 0.014). Findings were similar at all ages (EDV change – ptrend=0.357; RI change – ptrend=0.225), including 117 patients aged ≥80. EDV and RI changes were largest in 100 patients with clinic systolic-BP decrease ≥30 mmHg (mean/SD EDV change = 2.49/7.47 cm/s, p = 0.001; RI change −0.024/0.063, p < 0.0001). Conclusion There was no evidence of worsening of TCD haemodynamic indices associated with BP-lowering soon after TIA/non-disabling stroke, irrespective of age and degree of BP reduction. In fact, EDV increase and RI decrease observed after treatment of hypertensive patients suggest a decrease in distal vascular resistance.

We provide the first complete set of survival rate estimates for the Endangered Mediterranean monk sealMonachus monachusfrom birth into adulthood, as well as the first age-specific reproductive rates for the species. From 2002 to 2016, we obtained individual seal live encounter data through non-invasive monitoring techniques that were analyzed to estimate vital rates of Mediterranean monk seals of the Cabo Blanco (Western Sahara/Mauritania) population. From birth to age 2 mo, when pups molt, survival averaged 0.59, ranging from 0.41 to 0.74 among cohorts. From birth to 1 yr and from 1 to 2 yr, median estimated survival rates were 0.46 and 0.75, respectively. Beyond 2 yr, survival estimates differed by sex: 0.94 for males and 0.97 for females. From 2005 to 2016, we estimated a mean gross reproductive rate of 0.71. The youngest parturient females were 3 yr old. Fitted age-specific reproductive rates increased beginning at age 3 yr and exceeded 0.80 from age 6 to 17 yr. Despite low survival during the first 2 mo of life, the aggregate vital rates of the population are favorable for growth; a Leslie matrix containing our survival and fecundity estimates yielded an intrinsic growth rate of 1.058. Increasing abundance and favorable vital rates are a testament to the efficacy of the many measures taken to promote the conservation of this population.

BACKGROUND Acute wheezing is one of the most common hospital presentations for young children. Respiratory syncytial virus (RSV) and rhinovirus (RV) species A, B and the more recently described species C are implicated in the majority of these presentations. However, the relative importance and age-specificities of these viruses have not been defined. Hence, this study aimed to establish these relationships in a large cohort of prospectively recruited hospitalized children. METHODS The study cohort was 390 children 0-16 years of age presenting with acute wheezing to a children's emergency department, 96.4% being admitted. A nonwheezing control population of 190 was also recruited. Nasal samples were analyzed for viruses. RESULTS For the first 6 months of life, RSV was the dominant virus associated with wheezing (P < 0.001). From 6 months to 2 years, RSV, RV-A and RV-C were all common but none predominated. From 2 to 6 years, RV-C was the dominant virus detected (50-60% of cases), 2-3 times more common than RV-A and RSV, RSV decreasing to be absent from 4 to 7 years. RV-B was rare at all ages. RV-C was no longer dominant in children more than 10 years of age. Overall, RV-C was associated with lower mean oxygen saturation than any other virus (P < 0.001). Controls had no clear age distribution of viruses. CONCLUSION This study establishes a clear profile of age specificity of virus infections causing moderate to severe wheezing in children: RSV as the dominant cause in the first 6 months and RV-C in preschool-age children.

Testosterone levels decline as men age. There is little consensus on what testosterone levels are normal for aging men. In this paper, we estimate age-specific prevalence of testosterone deficiency in men using nor- mal mixture models when no generally agreed on cut-off value for defining testosterone deficiency is available. The Box-Cox power transformation is used to determine which transformation is most appropriate for correcting skewness in data and best suits normal mixture distributions. Parametric bootstrap tests are used to determine the number of components in a normal mixture.

Differential migration strategies in the same population provide an opportunity to investigate the development and constraints of the migratory programme. We used data from birds ringed from the large Danish breeding population of Great Cormorants, Phalacrocorax carbo sinensis, to investigate age- and sex-specific differences in migratory patterns, which may inform our understanding of the ontogeny of partial migration schedules or protandric advantages of males arriving at breeding grounds in advance of females. We tested spatial and temporal variation in migration strategy from migration distance, orientation and by region. We observed clear partial migration strategies in the combined data, and by group, following post-breeding dispersal. We found differential migration patterns by age, with migratory adults departing earlier than birds on their first migration. There was a tendency for a greater concentration of adults utilising sites in central Europe, while a higher than expected proportion of young birds occupied the periphery of the wintering range. Re-encounters of birds of known sex during autumn and winter indicated that males remained closer to the breeding site than females, with sex-specific regional segregation. While our results did not support the migration pattern of young birds being governed by an innate control of both direction and distance, it may be explained in part by intra-specific competition driving the resultant non-breeding distribution. This social dynamic may be extended to the differential migration patterns between the sexes. Furthermore, the sex-specific wintering distributions may explain the development of protandry within the partial migration system.

Aim We aimed to clarify whether snacking habits decrease the risk of all-cause mortality in an older Japanese population. Methods The study participants were 64- or 65-year-old community-dwelling residents recruited each survey year from 1996 through 2005. Data on the frequency of snacking and other lifestyle factors were obtained during the baseline survey using self-administered questionnaires, and the participants were followed up annually until the end of 2017. In total, 2943 participants (1484 men and 1459 women) were eligible. All-cause mortality was compared among participants grouped by frequency of snacking (no snacking, one to four times/week, or every day). Results The number of deaths recorded over the study period of 43 204 person-years was 357 (24.1%) for men and 173 (11.9%) for women. The mean +/- standard deviations for the follow-up period were 14.2 +/- 4.9 years in men and 15.2 +/- 4.5 years in women. Cox proportional hazard regression analyses showed that after adjusting for potential confounding factors, the hazard ratios for women were 0.64 (95% confidence interval [CI], 0.43-0.94) in the group that had a habit of snacking one to four times/week, and 0.93 (95% CI 0.63-1.36) in the group that had a habit of snacking every day compared with those in the no snacking group. These associations were not observed among men. Conclusions A moderate frequency of snacking slightly decreases the risk of all-cause mortality among women. Our findings might be useful for improving the nutrition statuses in older female adults. Geriatr Gerontol Int center dot center dot; center dot center dot: center dot center dot-center dot center dot Geriatr Gerontol Int 2021; center dot center dot: center dot center dot-center dot center dot.

Einleitung: Nach der Collectivity-of-Drinking-Cultures-Theorie von Skog finden Veränderungen des Alkoholkonsums in allen Bevölkerungsgruppen und -schichten als parallele Verschiebungen statt. Ziele des vorliegenden Beitrags sind (1) die Darstellung zeitlicher Trends des riskanten Konsums und des episodischen Rauschtrinkens nach Altersgruppen und Geschlecht und (2) die Prüfung, ob die Trends in allen Altersgruppen parallel verlaufen („Kollektivität“) oder zwischen Altersgruppen divergieren („Polarisierung“). Methoden: Datengrundlage sind 9 Erhebungen des Epidemiologischen Suchtsurveys (ESA) zwischen 1995 und 2018. Als Schwellenwert für riskanten Alkoholkonsum wurde ein täglicher Konsum von mehr als 12 g Reinalkohol bei Frauen beziehungsweise 24 g bei Männern herangezogen. Episodisches Rauschtrinken wurde als Konsum von 5 oder mehr Gläsern Alkohol (ca. 70 g Reinalkohol) an mindestens einem Tag in den letzten 30 Tagen definiert. Lineare Regressionen wurden für die Vorhersage des zeitlichen Effekts auf riskanten Konsum bzw. Rauschkonsum nach Altersgruppen (18–29, 30–39, 40–49 und 50–59 Jahre) und Geschlecht getrennt berechnet und auf Unterschiede geprüft. Ergebnisse: Die Entwicklungen riskanten Alkoholkonsums nach Altersgruppen verlaufen bei Männern weitgehend parallel, bei Frauen gegenläufig. Die Trends des episodischen Rauschtrinken weisen bei beiden Geschlechtern keine parallele Entwicklung auf: Während in der jüngsten und ältesten Altersgruppe die Prävalenz im Zeitverlauf anstieg, sank sie in den übrigen Altersgruppen. Diskussion: Vor dem Hintergrund einer generellen Abnahme spricht die Zunahme in den Trends risikoreichen Alkoholkonsums in bestimmten Gruppen für einen Ausbau verhaltenspräventiver Maßnahmen. Zur Fortsetzung der positiven Entwicklung und der Vermeidung einer Trendumkehr sollten zudem auf die Gesamtbevölkerung ausgerichtete Präventionsanstrengungen intensiviert werden, beispielsweise durch Erhöhung der Alkoholsteuer oder Reduktion der Verfügbarkeit von Alkohol. Introduction: According to Skog’s collectivity of drinking cultures theory, changes in alcohol consumption in all groups and strata of the population take place as parallel displacement in the distribution of consumption. The aims of the present paper are (1) to illustrate temporal trends in risky drinking and episodic heavy drinking by age and gender and (2) to examine whether the trends are parallel in all age groups (“collectivity”) or diverge between age groups (“polarisation”). Methods: The data are based on nine surveys of the Epidemiological Survey of Addiction (ESA) between 1995 and 2018. Risky drinking was defined as daily consumption of more than 12 g (for women) or 24 g (for men) of pure alcohol and episodic heavy drinking as consumption of five or more glasses of alcohol (about 70 g pure alcohol) on at least one day in the past 30 days. Linear regressions were calculated separately for age groups (18–29, 30–39, 40–49, and 50–59 years) and gender to predict the temporal effect on risky drinking or episodic heavy drinking and to test trends for differences. Results: The temporal changes of risky drinking by age group show soft collectivity among men and polarisation among women. Trends in episodic heavy drinking indicate polarisation for both genders; while the prevalence increased in the youngest and oldest age groups, it decreased in all other age groups. Discussion: In light of a general decrease, the increasing trends in risky drinking in specific groups indicate the need for strengthening behavioural prevention. For the positive development to continue and to avoid a trend reversal, public health measures such as alcohol tax increases and reductions of alcohol availability need to be intensified.

Background The majority of available studies on the AMH thresholds were not age-specific and performed the receiver operating characteristic curve (ROC) analysis, based on variations in sensitivity and specificity rather than positive and negative predictive values (PPV and NPV, respectively), which are more clinically applicable. Moreover, all of these studies used a pre-specified age categorization to report the age-specific cut-off values of AMH. Methods A total of 803 women, including 303 PCOS patients and 500 eumenorrheic non-hirsute control women, were enrolled in the present study. The PCOS group included PCOS women, aged 20–40 years, who were referred to the Reproductive Endocrinology Research Center, Tehran, Iran. The Rotterdam consensus criteria were used for diagnosis of PCOS. The control group was selected among women, aged 20–40 years, who participated in Tehran Lipid and Glucose cohort Study (TLGS). Generalized additive models (GAMs) were used to identify the optimal cut-off points for various age categories. The cut-off levels of AMH in different age categories were estimated, using the Bayesian method. Main results and the role of chance Two optimal cut-off levels of AMH (ng/ml) were identified at the age of 27 and 35 years, based on GAMs. The cut-off levels for the prediction of PCOS in the age categories of 20–27, 27–35, and 35–40 years were 5.7 (95 % CI: 5.48–6.19), 4.55 (95 % CI: 4.52–4.64), and 3.72 (95 % CI: 3.55–3.80), respectively. Based on the Bayesian method, the PPV and NPV of these cut-off levels were as follows: PPV = 0.98 (95 % CI: 0.96–0.99) and NPV = 0.40 (95 % CI: 0.30–0.51) for the age group of 20–27 years; PPV = 0.96 (95 % CI: 0.91–0.99) and NPV = 0.82 (95 % CI: 0.78–0.86) for the age group of 27–35 years; and PPV = 0.86 (95 % CI: 0.80–0.94) and NPV = 0.96 (95 % CI: 0.93–0.98) for the age group of 35–40 years. Conclusions Application of age-specific cut-off levels of AMH, according to the GAMs and Bayesian method, could elegantly assess the value of AMH in discriminating PCOS patients in all age categories.

Objective To analyze the age-specific temporal trends, in-hospital outcomes and readmissions for acute heart failure (HF). Background There is a paucity of data on the age-specific differences in the trends and outcomes of hospitalizations with acute HF. Methods The National Inpatients Sample database years 2002–2016 and the National Readmissions Database years 2013–2016 were used to identify primary hospitalizations for acute HF. We analyzed the age-specific temporal trends, in-hospital outcomes, and readmissions for acute HF. Results The annual rate of hospitalizations for acute HF declined from 456 per 100,000 people in 2002 to 356 per 100,000 people in 2016 (Ptrend 34 years). Conclusions This nationwide contemporary analysis demonstrated a decline in the annual rates of hospitalizations with acute HF across all age categories except those aged 18–44 years. There was a reduction in rates of in-hospital mortality among middle-aged and older patients, but not in those aged 18–34. In-hospital mortality exhibited a dichotomous relationship with age. There was an inverse relationship between age and 30-days HF readmissions.

Inherited predispositions to acute lymphoblastic leukemia have been well investigated in pediatric patients, but studies on adults, particularly Chinese patients, are limited. In this study, we conducted a genome-wide association study in 466 all-age Chinese patients with Acute lymphoblastic leukemia (ALL) and 1,466 non-ALL controls to estimate the impact of age on ALL susceptibility in the Chinese population. Among the 17 reported loci, 8 have been validated in pediatric and 1 in adult patients. The strongest association signal was identified at ARID5B locus and gradually decreased with age, while the signal at GATA3 exhibited the opposite trend and significantly impact on adult patients. With genome-wide approaches, germline variants at 2q14.3 rank as the top inherited predisposition to adult patients (e.g., rs73956024, P = 4.3 × 10-5) and separate the genetic risk of pediatric vs. adult patients (P = 3.6 × 10-6), whereas variants at 15q25.3 (e.g., rs11638062) have a similar impact on patients in different age groups (overall P = 2.9 × 10-7). Our analysis highlights the impact of age on genetic susceptibility to ALL in Chinese patients.

BACKGROUND Age-adjusted COVID-19 mortality estimates have exposed a previously hidden excess mortality burden for the US Hispanic population. Multiple explanations have been put forth, including unequal quality/access to health care, higher proportion of pre-existing health conditions, multigenerational household composition, and disproportionate representation in telecommute-unfriendly occupations. However, these hypotheses have been rarely tested. OBJECTIVE We examine age-stratified patterns of Hispanic COVID-19 mortality vis-a-vis patterns of exposure to evaluate the multiple posited hypotheses. METHODS We use a combination of public and restricted data from the Centers of Disease Control and Prevention and leverage national and subnational race- and age-stratified COVID-19 mortality and case burdens/advantages to evaluate the workplace vulnerability hypothesis. We also use individual-level information on prior health conditions and mortality from the case data to assess whether observed patterns are consistent with the other hypotheses. RESULTS Our results indicate that the disproportionate burdens for both COVID-19 case and mortality for the Hispanic population are largest among the working-age groups, supporting the hypothesis that workplace exposure plays a critical role in heightening vulnerability to COVID-19 mortality. We find little evidence to support the hypotheses regarding multigenerational household composition, pre-existing health conditions, or unequal quality/access to health care. CONCLUSION Our findings point to the key roles played by age structure and differential exposure in contributing to the disproportionately severe impact of COVID-19 on the Hispanic population. CONTRIBUTION We contribute evidence to explain the driving factors in the observed excess COVID-19 mortality burden among Hispanics. Our findings underscore the importance of focusing on more robust workplace protections, particularly for working-age minority populations. © 2021. D. Phuong Do & Reanne Frank.

Vessel strikes are a major threat impacting large whales globally. Juvenile whales often represent a high proportion of lethal vessel strikes, but few studies have investigated whether juvenile whales show different behaviors that might influence their risk of vessel strike. We evaluated how variability in habitat use and foraging behavior by age class influences the risk of vessel strike for humpback whales Megaptera novaeangliae in the New York Bight (NYB), a highly urbanized region with frequent vessel strikes. We used data from unmanned aerial vehicle (UAV) surveys to compare the habitat use and foraging behavior of adult and juvenile humpback whales and compared length measurements of foraging individuals with those confirmed to have been killed by vessel strikes. Further, using Automatic Information System data, we analyzed the speed and density of vessel traffic relative to humpback whale habitat use. The vast majority (93%) of humpback whales confirmed to have been struck by vessels in the NYB were juveniles. Whales foraging in nearshore waters were exclusively juveniles that were surface feeding, while both juveniles and adults foraged cooperatively in offshore waters. Passenger vessel density and speed were highest in nearshore waters. The habitat use and surface foraging behavior of juvenile humpback whales may make them particularly vulnerable to vessel strikes in nearshore waters, and passenger vessels in these waters may be a risk factor. This work highlights the importance of understanding age-specific differences in habitat use to better understand and mitigate the risk of anthropogenic threats to large whales.

Background: Current study aim to describe epidemiological, clinical and demographic features in patients confirmed to have COVID-19 in Balochistan Methods: This descriptive cross sectional Study was conducted during months of March and April 2020 based on the secondary data available regarding COVID-19 positive patients from the health service records of Government of Balochistan quarantine centers and hospitals during this period. Data was analyzed by using Excel and SPSS version 23. Mean and standard deviations are used for continuous variables like age and duration of stay (of recovered patients), while frequencies and percentages were used to describe age categories, point of entry and current status. Age specific case fatality rate is calculated by keeping deaths in numerator and confirmed cases in denominator. Results: Mean age of respondents was 35.3±16.12 years , two third of the study population i.e,652(76.3%) were males,353 (40.6)% were in the age group 30-49 years and 417(48.9%) had history of contact with COVID-19 case. Overall case fatality rate was 1.87% and Age Specific Mortality Rate was found to be highest (30%) in age group 70 years and above Conclusion: The epidemiologic behavior of COVID-19 infection introduced in Pakistani population from neighboring country has responded differently in community spread among different ethnic groups represented in different provinces of Pakistan. The case fatality ratios among Baloch ethnic group were much lower than international COVID-19 case responses

Background: The impact of age on the association between central aortic hemodynamics and left ventricular (LV) remodeling has not been well elucidated. We compared the relationship between measurements of central blood pressure (CBP) and LV mass index (LVMI) according to their ages (Methods: A total of 305 consecutive subjects (64.4 ± 10.9 years, 60.7% males) who underwent invasive coronary angiography (ICA) for the evaluation of coronary artery disease were prospectively enrolled. Just before ICA, CBP was measured at the aortic root using a pig-tail catheter, and CBP indices, including aortic systolic blood pressure (aSBP), aortic pulse pressure (aPP), aortic fractional pulse pressure (=aPP/mean aortic pressure), and aortic pulsatility index (=aPP/diastolic aortic pressure), were recorded. All subjects underwent transthoracic echocardiography, and LVMI was measured on the same day of ICA. Results: In simple linear correlation analyses, LVMI was associated with all CBP indices in subjects aged P P > .05 for each). In the younger age group (≤50 years), multivariable analysis showed that aSBP (β = 0.457, P= .021) and aPP (β = 0.610, P= .006) had a significant association with LVMI after adjusting for possible confounding factors. The results remained consistent even when analyzed in a 1:1 propensity score-matched cohort. In conclusion, invasively measured aPP showed the closest association with LVMI in subjects aged Conclusion: Aortic pulsatile hemodynamic status appears to have a greater effect on LV remodeling in younger people than in older people.

The critically endangered indri (Indri indri) is the largest extant lemur species and its population size is projected to decline over the next three generations due to habitat loss, hunting and climate change. Accurate information on the demographic parameters driving the population dynamics of indri is urgently needed to help decision-making regarding the conservation of this iconic species. We monitored and followed the life histories of 68 individually recognizable indris in 10 family groups in the Maromizaha New Protected Area (Madagascar) for 12 years. We estimated age and sex-specific survival trajectories using a Bayesian hierarchical survival model and found that the survival curves for male and female indris show a similar pattern, consistent with what found typically in primates; i.e., a high infant mortality rate which declines with age in the juvenile phase and increases again for adults. Also, life expectancies at 2 years of age (e2), were found to be similar between the sexes (e2 females = 7.8 years; e2 males = 7.5 years). We suggest that the lack of strong differences in the survival patterns for male and female indris are related to the strictly monogamous mating system and the lack of sexual dimorphism in this species. Our study provides, for the first time, robust estimates for demographic parameters of indris and one of the very few datasets on survival trajectories available for primates.

Comparisons of the utility and accuracy of methods for measuring social interactions relevant to disease transmission are rare. To increase the evidence base supporting specific methods to measure social interaction, we compared data from self-reported contact surveys and wearable proximity sensors from a cohort of schoolchildren in the Pittsburgh metropolitan area. Although the number and type of contacts recorded by each participant differed between the two methods, we found good correspondence between the two methods in aggregate measures of age-specific interactions. Fewer, but longer, contacts were reported in surveys, relative to the generally short proximal interactions captured by wearable sensors. When adjusted for expectations of proportionate mixing, though, the two methods produced highly similar, assortative age-mixing matrices. These aggregate mixing matrices, when used in simulation, resulted in similar estimates of risk of infection by age. While proximity sensors and survey methods may not be interchangeable for capturing individual contacts, they can generate highly correlated data on age-specific mixing patterns relevant to the dynamics of respiratory virus transmission.

BackgroundKnowing the age-specific rates at which individuals infected with SARS-CoV-2 develop severe and critical disease is essential for designing public policy, for infectious disease modeling, and for individual risk evaluation.MethodsIn this study, we present the first estimates of these rates using multi-country serology studies, and public data on hospital admissions and mortality from early to mid-2020. We combine these under a Bayesian framework that accounts for the high heterogeneity between data sources and their respective uncertainties. We also validate our results using an indirect method based on infection fatality rates and hospital mortality data.ResultsOur results show that the risk of severe and critical disease increases exponentially with age, but much less steeply than the risk of fatal illness. We also show that our results are consistent across several robustness checks.ConclusionA complete evaluation of the risks of SARS-CoV-2 for health must take non-fatal disease outcomes into account, particularly in young populations where they can be 2 orders of magnitude more frequent than deaths.