Search

Your search keyword '"Agerbæk, Mette Ø."' showing total 28 results
Start Over Author "Agerbæk, Mette Ø."
28 results on '"Agerbæk, Mette Ø."'

1. Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate

Author

Vidal-Calvo, Elena Ethel, Martin-Salazar, Anne, Choudhary, Swati, Dagil, Robert, Raghavan, Sai Sundar Rajan, Duvnjak, Lara, Nordmaj, Mie Anemone, Clausen, Thomas Mandel, Skafte, Ann, Oberkofler, Jan, Wang, Kaituo, Agerbæk, Mette Ø, Løppke, Caroline, Jørgensen, Amalie Mundt, Ropac, Daria, Mujollari, Joana, Willis, Shona, Garcias López, Agnès, Miller, Rebecca Louise, Karlsson, Richard Torbjörn Gustav, Goerdeler, Felix, Chen, Yen-Hsi, Colaço, Ana R., Wang, Yong, Lavstsen, Thomas, Martowicz, Agnieszka, Nelepcu, Irina, Marzban, Mona, Oo, Htoo Zarni, Ørum-Madsen, Maj Sofie, Wang, Yuzhuo, Nielsen, Morten A., Clausen, Henrik, Wierer, Michael, Wolf, Dominik, Gögenur, Ismail, Theander, Thor G., Al-Nakouzi, Nader, Gustavsson, Tobias, Daugaard, Mads, and Salanti, Ali

Published
2024
Full Text
View/download PDF

3. Author Correction: The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

Author

Agerbæk, Mette Ø., Bang-Christensen, Sara R., Yang, Ming-Hsin, Clausen, Thomas M., Pereira, Marina A., Sharma, Shreya, Ditlev, Sisse B., Nielsen, Morten A., Choudhary, Swati, Gustavsson, Tobias, Sorensen, Poul H., Meyer, Tim, Propper, David, Shamash, Jonathan, Theander, Thor G., Aicher, Alexandra, Daugaard, Mads, Heeschen, Christopher, and Salanti, Ali

Published
2022
Full Text
View/download PDF

4. Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

Author

Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, Sandeep K., Spliid, Charlotte B., Wang, Yong, Gustavsson, Tobias, Sandoval, Daniel R., Vidal-Calvo, Elena Ethel, Choudhary, Swati, Agerbaek, Mette Ø, Lindorff-Larsen, Kresten, Nielsen, Morten A., Theander, Thor G., Sharp, Joshua S., Clausen, Thomas Mandel, Gourdon, Pontus, and Salanti, Ali

Published
2021
Full Text
View/download PDF

7. Data from Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility

Author

Clausen, Thomas Mandel, primary, Pereira, Marina Ayres, primary, Al Nakouzi, Nader, primary, Oo, Htoo Zarni, primary, Agerbæk, Mette Ø, primary, Lee, Sherry, primary, Ørum-Madsen, Maj Sofie, primary, Kristensen, Anders Riis, primary, El-Naggar, Amal, primary, Grandgenett, Paul M., primary, Grem, Jean L., primary, Hollingsworth, Michael A., primary, Holst, Peter J., primary, Theander, Thor, primary, Sorensen, Poul H., primary, Daugaard, Mads, primary, and Salanti, Ali, primary

Published
2023
Full Text
View/download PDF

8. Supplemental Figure 3 from Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility

Author

Clausen, Thomas Mandel, primary, Pereira, Marina Ayres, primary, Al Nakouzi, Nader, primary, Oo, Htoo Zarni, primary, Agerbæk, Mette Ø, primary, Lee, Sherry, primary, Ørum-Madsen, Maj Sofie, primary, Kristensen, Anders Riis, primary, El-Naggar, Amal, primary, Grandgenett, Paul M., primary, Grem, Jean L., primary, Hollingsworth, Michael A., primary, Holst, Peter J., primary, Theander, Thor, primary, Sorensen, Poul H., primary, Daugaard, Mads, primary, and Salanti, Ali, primary

Published
2023
Full Text
View/download PDF

9. Supplemental Figure 1 from Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility

Author

Clausen, Thomas Mandel, primary, Pereira, Marina Ayres, primary, Al Nakouzi, Nader, primary, Oo, Htoo Zarni, primary, Agerbæk, Mette Ø, primary, Lee, Sherry, primary, Ørum-Madsen, Maj Sofie, primary, Kristensen, Anders Riis, primary, El-Naggar, Amal, primary, Grandgenett, Paul M., primary, Grem, Jean L., primary, Hollingsworth, Michael A., primary, Holst, Peter J., primary, Theander, Thor, primary, Sorensen, Poul H., primary, Daugaard, Mads, primary, and Salanti, Ali, primary

Published
2023
Full Text
View/download PDF

10. Supplemental Figure 2 from Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility

Author

Clausen, Thomas Mandel, primary, Pereira, Marina Ayres, primary, Al Nakouzi, Nader, primary, Oo, Htoo Zarni, primary, Agerbæk, Mette Ø, primary, Lee, Sherry, primary, Ørum-Madsen, Maj Sofie, primary, Kristensen, Anders Riis, primary, El-Naggar, Amal, primary, Grandgenett, Paul M., primary, Grem, Jean L., primary, Hollingsworth, Michael A., primary, Holst, Peter J., primary, Theander, Thor, primary, Sorensen, Poul H., primary, Daugaard, Mads, primary, and Salanti, Ali, primary

Published
2023
Full Text
View/download PDF

11. Supplemental Data from Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility

Author

Clausen, Thomas Mandel, primary, Pereira, Marina Ayres, primary, Al Nakouzi, Nader, primary, Oo, Htoo Zarni, primary, Agerbæk, Mette Ø, primary, Lee, Sherry, primary, Ørum-Madsen, Maj Sofie, primary, Kristensen, Anders Riis, primary, El-Naggar, Amal, primary, Grandgenett, Paul M., primary, Grem, Jean L., primary, Hollingsworth, Michael A., primary, Holst, Peter J., primary, Theander, Thor, primary, Sorensen, Poul H., primary, Daugaard, Mads, primary, and Salanti, Ali, primary

Published
2023
Full Text
View/download PDF

12. The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

Author

Agerbæk, Mette Ø., Bang-Christensen, Sara R., Yang, Ming-Hsin, Clausen, Thomas M., Pereira, Marina A., Sharma, Shreya, Ditlev, Sisse B., Nielsen, Morten A., Choudhary, Swati, Gustavsson, Tobias, Sorensen, Poul H., Meyer, Tim, Propper, David, Shamash, Jonathan, Theander, Thor G., Aicher, Alexandra, Daugaard, Mads, Heeschen, Christopher, and Salanti, Ali

Published
2018
Full Text
View/download PDF

15. Optimization of rVAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells

Author

Sand, Nicolai T., primary, Petersen, Tobias B., additional, Bang-Christensen, Sara R., additional, Ahrens, Theresa D., additional, Løppke, Caroline, additional, Jørgensen, Amalie M., additional, Gustavsson, Tobias, additional, Choudhary, Swati, additional, Theander, Thor G., additional, Salanti, Ali, additional, and Agerbæk, Mette Ø., additional

Published
2020
Full Text
View/download PDF

16. Burkitt lymphoma express oncofetal Chondroitin Sulfate without being a reservoir for placental malaria sequestration

Author

Agerbæk, Mette Ø., Pereira, Marina A., Clausen, Thomas M., Pehrson, Caroline, Oo, Htoo Zarni, Spliid, Charlotte, Rich, Jamie R., Fung, Vincent, Nkrumah, Francis, Neequaye, Janet, Biggar, Robert J., Reynolds, Steven J., Tosato, Giovanna, Pullarkat, Sheeja T., Ayers, Leona W., Theander, Thor G., Daugaard, Mads, Bhatia, Kishor, Nielsen, Morten A., Mbulaiteye, Sam M., and Salanti, Ali

Subjects
Male, Erythrocytes, Adolescent, Placenta, Chondroitin Sulfates, Plasmodium falciparum, Antibodies, Protozoan, Antigens, Protozoan, Burkitt Lymphoma, Article, Recombinant Proteins, Antigens, Neoplasm, Pregnancy, Cell Line, Tumor, Child, Preschool, Immunoglobulin G, embryonic structures, parasitic diseases, Humans, Female, Proteoglycans, Malaria, Falciparum, Child
Abstract

Burkitt lymphoma (BL) is a malignant disease, which is frequently found in areas with holoendemic Plasmodium falciparum malaria. We have previously found that the VAR2CSA protein is present on malaria-infected erythrocytes and facilitates a highly specific binding to the placenta. OfCS is absent from other non-malignant tissues and thus VAR2CSA generally facilitates parasite sequestration and accumulation in pregnant women. In this study, we show that the specific receptor for VAR2CSA, the oncofetal chondroitin sulfate (ofCS), is likewise present in BL tissue and cell lines. We therefore explored whether ofCS in BL could act as anchor-site for VAR2CSA-expressing infected erythrocytes. In contrast to the placenta, we found no evidence of in vivo sequestering of infected erythrocytes in the BL tissue. Furthermore, we found VAR2CSA specific antibody titers in children with endemic BL to be lower than in control children from the same malaria endemic region. The abundant presence of ofCS in BL tissue and the absence of ofCS in non-malignant tissue, encouraged us to examine whether recombinant VAR2CSA could be used to target BL. We confirmed the binding of VAR2CSA to BL-derived cells and showed that a VAR2CSA drug conjugate efficiently killed the BL-derived cell lines in vitro. These results identify ofCS as a novel therapeutic BL target and highlight how VAR2CSA could be used as a tool for the discovery of novel approaches for directing BL therapy.

Published
2017

17. Abstract 4595: The VAR2CSA malaria protein efficiently retrieves CTCs from a broad spectrum of cancers

Author

Agerbæk, Mette Ø., primary, Bang-Christensen, Sara R., additional, Yang, Ming-Hsin, additional, Clausen, Thomas M., additional, Ditlev, Sisse B., additional, Pereira, Marina A., additional, Nielsen, Morten A., additional, Choudhary, Swati, additional, Gustavsson, Tobias, additional, Sorensen, Poul H., additional, Meyer, Tim, additional, Propper, David, additional, Shamash, Jonathan, additional, Theander, Thor G., additional, Aicher, Alexandra, additional, Daugaard, Mads, additional, Heeschen, Christopher, additional, and Salanti, Ali, additional

Published
2018
Full Text
View/download PDF

18. An Oncofetal Glycosaminoglycan Modification Provides Therapeutic Access to Cisplatin-resistant Bladder Cancer

Author

Seiler, Roland, primary, Oo, Htoo Zarni, additional, Tortora, Davide, additional, Clausen, Thomas M., additional, Wang, Chris K., additional, Kumar, Gunjan, additional, Pereira, Marina Ayres, additional, Ørum-Madsen, Maj S., additional, Agerbæk, Mette Ø., additional, Gustavsson, Tobias, additional, Nordmaj, Mie A., additional, Rich, Jamie R., additional, Lallous, Nada, additional, Fazli, Ladan, additional, Lee, Sherry S., additional, Douglas, James, additional, Todenhöfer, Tilman, additional, Esfandnia, Shaghayegh, additional, Battsogt, Dulguun, additional, Babcook, John S., additional, Al-Nakouzi, Nader, additional, Crabb, Simon J., additional, Moskalev, Igor, additional, Kiss, Bernhard, additional, Davicioni, Elai, additional, Thalmann, George N., additional, Rennie, Paul S., additional, Black, Peter C., additional, Salanti, Ali, additional, and Daugaard, Mads, additional

Published
2017
Full Text
View/download PDF

19. Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration

Author

Agerbaek, Mette Ø., primary, Pereira, Marina A., additional, Clausen, Thomas M., additional, Pehrson, Caroline, additional, Oo, Htoo Zarni, additional, Spliid, Charlotte, additional, Rich, Jamie R., additional, Fung, Vincent, additional, Nkrumah, Francis, additional, Neequaye, Janet, additional, Biggar, Robert J., additional, Reynolds, Steven J., additional, Tosato, Giovanna, additional, Pullarkat, Sheeja T., additional, Ayers, Leona W., additional, Theander, Thor G., additional, Daugaard, Mads, additional, Bhatia, Kishor, additional, Nielsen, Morten A., additional, Mbulaiteye, Sam M., additional, and Salanti, Ali, additional

Published
2017
Full Text
View/download PDF

20. Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility

Author

Clausen, Thomas Mandel, primary, Pereira, Marina Ayres, additional, Al Nakouzi, Nader, additional, Oo, Htoo Zarni, additional, Agerbæk, Mette Ø, additional, Lee, Sherry, additional, Ørum-Madsen, Maj Sofie, additional, Kristensen, Anders Riis, additional, El-Naggar, Amal, additional, Grandgenett, Paul M., additional, Grem, Jean L., additional, Hollingsworth, Michael A., additional, Holst, Peter J., additional, Theander, Thor, additional, Sorensen, Poul H., additional, Daugaard, Mads, additional, and Salanti, Ali, additional

Published
2016
Full Text
View/download PDF

21. Abstract 3798: A glycan-binding malaria protein provides therapeutic access to cisplatin-resistant bladder cancer

Author

OO, HTOO ZARNI, primary, Seiler, Roland, additional, Lee, Sherry S., additional, Tortora, Davide, additional, Kumar, Gunjan, additional, Wang, Chris, additional, Clausen, Thomas M., additional, Agerbæk, Mette Ø., additional, Rich, Jamie R., additional, Babcook, John S., additional, Black, Peter C., additional, Salanti, Ali, additional, and Daugaard, Mads, additional

Published
2016
Full Text
View/download PDF

23. Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

Author

Salanti, Ali, primary, Clausen, Thomas M., additional, Agerbæk, Mette Ø., additional, Al Nakouzi, Nader, additional, Dahlbäck, Madeleine, additional, Oo, Htoo Z., additional, Lee, Sherry, additional, Gustavsson, Tobias, additional, Rich, Jamie R., additional, Hedberg, Bradley J., additional, Mao, Yang, additional, Barington, Line, additional, Pereira, Marina A., additional, LoBello, Janine, additional, Endo, Makoto, additional, Fazli, Ladan, additional, Soden, Jo, additional, Wang, Chris K., additional, Sander, Adam F., additional, Dagil, Robert, additional, Thrane, Susan, additional, Holst, Peter J., additional, Meng, Le, additional, Favero, Francesco, additional, Weiss, Glen J., additional, Nielsen, Morten A., additional, Freeth, Jim, additional, Nielsen, Torsten O., additional, Zaia, Joseph, additional, Tran, Nhan L., additional, Trent, Jeff, additional, Babcook, John S., additional, Theander, Thor G., additional, Sorensen, Poul H., additional, and Daugaard, Mads, additional

Published
2015
Full Text
View/download PDF

24. The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine

Author

Nielsen, Morten A., primary, Resende, Mafalda, additional, de Jongh, Willem A., additional, Ditlev, Sisse B., additional, Mordmüller, Benjamin, additional, Houard, Sophie, additional, Ndam, Nicaise Tuikue, additional, Agerbæk, Mette Ø., additional, Hamborg, Mette, additional, Massougbodji, Achille, additional, Issifou, Saddou, additional, Strøbæk, Anette, additional, Poulsen, Lars, additional, Leroy, Odile, additional, Kremsner, Peter G., additional, Chippaux, Jean-Philippe, additional, Luty, Adrian J. F., additional, Deloron, Philippe, additional, Theander, Thor G., additional, Dyring, Charlotte, additional, and Salanti, Ali, additional

Published
2015
Full Text
View/download PDF

26. Structural and Functional Insight into How the Plasmodium falciparum VAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria

Author

Clausen, Thomas M., primary, Christoffersen, Stig, additional, Dahlbäck, Madeleine, additional, Langkilde, Annette Eva, additional, Jensen, Kamilla E., additional, Resende, Mafalda, additional, Agerbæk, Mette Ø., additional, Andersen, Daniel, additional, Berisha, Besim, additional, Ditlev, Sisse B., additional, Pinto, Vera V., additional, Nielsen, Morten A., additional, Theander, Thor G., additional, Larsen, Sine, additional, and Salanti, Ali, additional

Published
2012
Full Text
View/download PDF

27. CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches.

Author

Tang J, Zheng Q, Wang Q, Zhao Y, Ananthanarayanan P, Reina C, Šabanović B, Jiang K, Yang MH, Meny CC, Wang H, Agerbaek MØ, Clausen TM, Gustavsson T, Wen C, Borghi F, Mellano A, Fenocchio E, Gregorc V, Sapino A, Theander TG, Fu D, Aicher A, Salanti A, Shen B, and Heeschen C

Abstract

Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that circulating tumor cells (CTCs) offer a promising alternative, serving as a "liquid biopsy" that enables the generation of in vitro 3D models and highly aggressive in vivo models for functional and molecular studies in advanced PDAC. Within the retrieved CTC pool (median 65 CTCs/5 mL), we identify a subset (median content 8.9%) of CXCR4 + CTCs displaying heightened stemness and metabolic traits, reminiscent of circulating cancer stem cells. Through comprehensive analysis, we elucidate the importance of CTC-derived models for identifying potential targets and guiding treatment strategies. Screening of stemness-targeting compounds identified stearoyl-coenzyme A desaturase (SCD1) as a promising target for advanced PDAC. These results underscore the pivotal role of CTC-derived models in uncovering therapeutic avenues and ultimately advancing personalized care in PDAC., Competing Interests: Declaration of interests M.Ø.A., T.M.C., T.G.T., and A. Salanti are shareholders in VAR2Pharma ApS holding a patent on utilizing rVAR2 for diagnosing cancer and were not involved in the data analysis., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
Full Text
View/download PDF

28. Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein.

Author

Bang-Christensen SR, Pedersen RS, Pereira MA, Clausen TM, Løppke C, Sand NT, Ahrens TD, Jørgensen AM, Lim YC, Goksøyr L, Choudhary S, Gustavsson T, Dagil R, Daugaard M, Sander AF, Torp MH, Søgaard M, Theander TG, Østrup O, Lassen U, Hamerlik P, Salanti A, and Agerbæk MØ

Subjects
Brain Neoplasms metabolism, Cell Count methods, Cell Line, Tumor, Chondroitin Sulfate Proteoglycans blood, Glioma metabolism, Humans, Proof of Concept Study, Recombinant Proteins pharmacology, Antigens, Protozoan pharmacology, Biomarkers, Tumor blood, Brain Neoplasms diagnosis, Cell Separation methods, Glioma diagnosis, Neoplastic Cells, Circulating metabolism
Abstract

Diffuse gliomas are the most common primary malignant brain tumor. Although extracranial metastases are rarely observed, recent studies have shown the presence of circulating tumor cells (CTCs) in the blood of glioma patients, confirming that a subset of tumor cells are capable of entering the circulation. The isolation and characterization of CTCs could provide a non-invasive method for repeated analysis of the mutational and phenotypic state of the tumor during the course of disease. However, the efficient detection of glioma CTCs has proven to be challenging due to the lack of consistently expressed tumor markers and high inter- and intra-tumor heterogeneity. Thus, for this field to progress, an omnipresent but specific marker of glioma CTCs is required. In this article, we demonstrate how the recombinant malaria VAR2CSA protein (rVAR2) can be used for the capture and detection of glioma cell lines that are spiked into blood through binding to a cancer-specific oncofetal chondroitin sulfate (ofCS). When using rVAR2 pull-down from glioma cells, we identified a panel of proteoglycans, known to be essential for glioma progression. Finally, the clinical feasibility of this work is supported by the rVAR2-based isolation and detection of CTCs from glioma patient blood samples, which highlights ofCS as a potential clinical target for CTC isolation., Competing Interests: The technology to diagnose cancer through rVAR2 is owned by VarCT Diagnostics through a license from VAR2Pharmaceuticals. AS, MØA, TGT, MD and TMC are cofounders of VAR2Pharmaceuticals.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results