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2. Pivotal trial of the Neuroform Atlas stent for treatment of posterior circulation aneurysms: one-year outcomes

Author

Jankowitz, Brian T, Jadhav, Ashutosh P, Gross, Bradley, Jovin, Tudor G, Alhajeri, Abdulnasser A, Fraser, Justin F, Hanel, Ricardo A, Sauvageau, Eric, Aghaebrahim, Amin, Frei, Donald, Bellon, Richard, Loy, David, Puri, Ajit S, Malek, Adel M, Thomas, Ajith, Toth, Gabor, Lopes, Demetrius Klee, Crowley, R Webster, Arthur, Adam S, Reavey-Cantwell, John, Lin, Eugene, Siddiqui, Adnan H, Alexander, Michael J, Khaldi, Ahmad, Colby, Geoffrey P, Caplan, Justin M, Satti, Sudhakar R, Turk, Aquilla S, Spiotta, Alejandro M, Klucznik, Richard, Hallam, Danial K, Kung, David, Froehler, Michael T, Callison, R Charles, Kan, Peter, Hetts, Steven W, and Zaidat, Osama O

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Bioengineering, Clinical Trials and Supportive Activities, Assistive Technology, Stroke, Neurosciences, Clinical Research, Aged, Cerebral Angiography, Embolization, Therapeutic, Female, Humans, Intracranial Aneurysm, Middle Aged, Prospective Studies, Retrospective Studies, Stents, Treatment Outcome, aneurysm, coil, stent, Clinical sciences
Abstract

BackgroundStent-assisted coiling of wide-necked intracranial aneurysms (IAs) using the Neuroform Atlas Stent System (Atlas) has shown promising results.ObjectiveTo present the primary efficacy and safety results of the ATLAS Investigational Device Exemption (IDE) trial in a cohort of patients with posterior circulation IAs.MethodsThe ATLAS trial is a prospective, multicenter, single-arm, open-label study of unruptured, wide-necked, IAs treated with the Atlas stent and adjunctive coiling. This study reports the results of patients with posterior circulation IAs. The primary efficacy endpoint was complete aneurysm occlusion (Raymond-Roy (RR) class I) on 12-month angiography, in the absence of re-treatment or parent artery stenosis >50%. The primary safety endpoint was any major ipsilateral stroke or neurological death within 12 months. Adjudication of the primary endpoints was performed by an imaging core laboratory and a Clinical Events Committee.ResultsThe ATLAS trial enrolled and treated 116 patients at 25 medical centers with unruptured, wide-necked, posterior circulation IAs (mean age 60.2±10.5 years, 81.0% (94/116) female). Stents were placed in all patients with 100% technical success rate. A total of 95/116 (81.9%) patients had complete angiographic follow-up at 12 months, of whom 81 (85.3%) had complete aneurysm occlusion (RR class I). The primary effectiveness outcome was achieved in 76.7% (95% CI 67.0% to 86.5%) of patients. Overall, major ipsilateral stroke and secondary persistent neurological deficit occurred in 4.3% (5/116) and 1.7% (2/116) of patients, respectively.ConclusionsIn the ATLAS IDE posterior circulation cohort, the Neuroform Atlas Stent System with adjunctive coiling demonstrated high rates of technical and safety performance. Trial registration number https://clinicaltrials.gov/ct2/show/NCT02340585.

Published
2022

3. Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial

Author

Sarraj, Amrou, Abraham, Michael G, Hassan, Ameer E, Blackburn, Spiros, Kasner, Scott E, Ortega-Gutierrez, Santiago, Hussain, Muhammad Shazam, Chen, Michael, Johns, Hannah, Churilov, Leonid, Pujara, Deep K, Shaker, Faris, Maali, Laith, Cardona Portela, Pere, Herial, Nabeel A, Gibson, Daniel, Kozak, Osman, Arenillas, Juan F, Yan, Bernard, Pérez de la Ossa, Natalia, Sundararajan, Sophia, Hu, Yin C, Cordato, Dennis J, Manning, Nathan W, Hanel, Ricardo A, Aghaebrahim, Amin N, Budzik, Ronald F, Hicks, William J, Blasco, Jordi, Wu, Teddy Y, Tsai, Jenny P, Schaafsma, Joanna D, Gandhi, Chirag D, Al-Mufti, Fawaz, Sangha, Navdeep, Warach, Steven, Kleinig, Timothy J, Yogendrakumar, Vignan, Ng, Felix, Samaniego, Edgar A, Abdulrazzak, Mohammad A, Parsons, Mark W, Rahbar, Mohammad H, Nguyen, Thanh N, Fifi, Johanna T, Mendes Pereira, Vitor, Lansberg, Maarten G, Albers, Greg W, Furlan, Anthony J, Jabbour, Pascal, Sitton, Clark W, Sila, Cathy, Bambakidis, Nicholas, Davis, Stephen M, Wechsler, Lawrence, Hill, Michael D, Grotta, James C, Ribo, Marc, and Campbell, Bruce C V

Published
2024
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4. New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial.

Author

Gupta, Rishi, Saver, Jeffrey L, Levy, Elad, Zaidat, Osama O, Yavagal, Dileep, Liebeskind, David S, Khaldi, Ahmad, Gross, Bradley, Lang, Michael, Narayanan, Sandra, Jankowitz, Brian, Snyder, Kenneth, Siddiqui, Adnan, Davies, Jason, Lin, Eugene, Hassan, Ameer, Hanel, Ricardo, Aghaebrahim, Amin, Kaushal, Ritesh, Malek, Ali, Mueller-Kronast, Nils, Starke, Robert, Bozorgchami, Hormozd, Nesbit, Gary, Horikawa, Masahiro, Priest, Ryan, Liu, Jesse, Budzik, Ronald F, Pema, Peter, Vora, Nirav, Taqi, M Asif, Samaniego, Edgar, Wang, Qingliang Tony, Nossek, Erez, Dabus, Guilherme, Linfante, Italo, Puri, Ajit, Abergel, Eitan, Starkman, Sidney, Tateshima, Satoshi, Jadhav, Ashutosh P, and TIGER Trial Investigators

Subjects
TIGER Trial Investigators, Humans, Thrombectomy, Aged, Middle Aged, Female, Male, Endovascular Procedures, Ischemic Stroke, goal, intracranial hemorrhage, laboratories, reperfusion, stent, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

[Figure: see text].

Published
2021

5. Pivotal Trial of the Neuroform Atlas Stent for Treatment of Anterior Circulation Aneurysms

Author

Zaidat, Osama O, Hanel, Ricardo A, Sauvageau, Eric A, Aghaebrahim, Amin, Lin, Eugene, Jadhav, Ashutosh P, Jovin, Tudor G, Khaldi, Ahmad, Gupta, Rishi G, Johnson, Andrew, Frei, Donald, Loy, David, Malek, Adel, Toth, Gabor, Siddiqui, Adnan, Reavey-Cantwell, John, Thomas, Ajith, Hetts, Steven W, Jankowitz, Brian T, Gross, Bradley, Ducruet, Andrew, Panczkowski, David, Shoirah, Hazem, Al-Bayati, Alhamza, Weiner, Greg, Kenmuir, Cynthia, Tadi, Prasanna, Walker, Gregory, Johnson, K, Frei, Don, Bellon, Richard, Atchie, Benjamin, Kaminsky, Ian, Huddle, Dan, Bain, Mark, Rasmussen, Peter, Hussain, M Shazam, Moore, Nina, Masaryk, Thomas, Elgabaly, Mohamed, Cerejo, Russell, Hardman, Julian, John, Seby, Bauer, Andrew, Peih-Chir Tsai, Jenny, Levy, Elad, Snyder, Kenneth, Davies, Jason, Ogilvy, Christopher, Rivet, Dennis, Alexander, Michael, Moser, Franklin, Maya, Marcel, Schiraldi, Michael, Eboli, Paula, Caplan, Justin, Jiang, Bowen, Bender, Matthew, Colby, Geoffrey, Satti, Sudhakar, Sivapatham, Thinesh, Kung, David, Pukenas, Bryan, Hurst, Robert, Smith, Michelle J, Puri, Ajit, Massari, Francesco, Rex, David, Fraser, Justin, Grupke, Stephen, Alhajeri, Abdulnasser, Klucznik, Richard, Diaz, Orlando, Britz, Gavin, Zhan, Yi, Spiotta, Alejandro, Lena, Jonathan, Turk, Aquilla, Chaudry, Mohamad, Fargen, Kyle, Turner, Raymond, Kan, Peter, Duckworth, Edward, Asif Taqi, Muhammad, Hou, Samuel, Arthur, Adam S, Elijovich, Lucas, Hoit, Daniel, Nickele, Christopher, Vachhani, Jay, Thomas Doss, Vinodh, Crowley, Richard, Lopes, Demetrius, Chen, Michael, Hallam, Danial, Ghodke, Basavaraj, Kim, Louis, Callison, Richard, Alshekhlee, Amer, and Kale, Sushant

Subjects
Bioengineering, Stroke, Assistive Technology, Neurosciences, Clinical Research, Clinical Trials and Supportive Activities, Brain Disorders, Adult, Aged, Embolization, Therapeutic, Endovascular Procedures, Female, Humans, Intracranial Aneurysm, Male, Middle Aged, Stents, Treatment Outcome, angiography, intracranial aneurysm, middle cerebral artery, retreatment, stent, ATLAS Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeStent-assisted coil embolization using the new generation Neuroform Atlas Stent System has shown promising safety and efficacy. The primary study results of the anterior circulation aneurysm cohort of the treatment of wide-neck, saccular, intracranial, aneurysms with the Neuroform Atlas Stent System (ATLAS trial [Safety and Effectiveness of the Treatment of Wide Neck, Saccular Intracranial Aneurysms With the Neuroform Atlas Stent System]) are presented.MethodsATLAS IDE trial (Investigational Device Exemption) is a prospective, multicenter, single-arm, open-label study of wide-neck (neck ≥4 mm or dome-to-neck ratio 50%) at the target location. The primary safety end point was any major stroke or ipsilateral stroke or neurological death within 12 months. Adjudication of the primary end points was performed by an independent Imaging Core Laboratory and the Clinical Events Committee.ResultsA total of 182 patients with wide-neck anterior circulation aneurysms at 25 US centers were enrolled. The mean age was 60.3±11.4 years, 73.1% (133/182) women, and 80.8% (147/182) white. Mean aneurysm size was 6.1±2.2 mm, mean neck width was 4.1±1.2 mm, and mean dome-to-neck ratio was 1.2±0.3. The most frequent aneurysm locations were the anterior communicating artery (64/182, 35.2%), internal carotid artery ophthalmic artery segment (29/182, 15.9%), and middle cerebral artery bifurcation (27/182, 14.8%). Stents were placed in the anticipated anatomic location in all patients. The study met both primary safety and efficacy end points. The composite primary efficacy end point of complete aneurysm occlusion (Raymond-Roy 1) without parent artery stenosis or aneurysm retreatment was achieved in 84.7% (95% CI, 78.6%-90.9%) of patients. Overall, 4.4% (8/182, 95% CI, 1.9%-8.5%) of patients experienced a primary safety end point of major ipsilateral stroke or neurological death.ConclusionsIn the ATLAS IDE anterior circulation aneurysm cohort premarket approval study, the Neuroform Atlas stent with adjunctive coiling met the primary end points and demonstrated high rates of long-term complete aneurysm occlusion at 12 months, with 100% technical success and

Published
2020

7. Use of Artificial Intelligence Software (Viz-AI) to Detect Intracranial Aneurysms: A Comprehensive Stroke Center Experience.

Author

De Toledo, Otavio F., primary, Gutierrez-Aguirre, Salvador F., additional, Lara-Velazquez, Montserrat, additional, Qureshi, Adnan I., additional, Camp, Wendy, additional, Erazu, Fernanda, additional, Benalia, Victor H.C., additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, and Hanel, Ricardo A., additional

Published
2024
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8. Clinical relevance of intracranial hemorrhage after thrombectomy versus medical management for large core infarct: a secondary analysis of the SELECT2 randomized trial

Author

Chen, Michael, primary, Joshi, Krishna C, additional, Kolb, Bradley, additional, Sitton, Clark W, additional, Pujara, Deep Kiritbhai, additional, Abraham, Michael G, additional, Ortega-Gutierrez, Santiago, additional, Kasner, Scott E, additional, Hussain, Shazam M, additional, Churilov, Leonid, additional, Blackburn, Spiros, additional, Sundararajan, Sophia, additional, Hu, Yin C, additional, Herial, Nabeel, additional, Arenillas, Juan F, additional, Tsai, Jenny P, additional, Budzik, Ronald F, additional, Hicks, William, additional, Kozak, Osman, additional, Yan, Bernard, additional, Cordato, Dennis, additional, Manning, Nathan W, additional, Parsons, Mark, additional, Hanel, Ricardo A, additional, Aghaebrahim, Amin, additional, Wu, Teddy, additional, Cardona Portela, Pere, additional, Gandhi, Chirag D, additional, Al-Mufti, Fawaz, additional, Perez de la Ossa, Natalia, additional, Schaafsma, Joanna, additional, Blasco, Jordi, additional, Sangha, Navdeep, additional, Warach, Steven, additional, Kleinig, Timothy J, additional, Johns, Hannah, additional, Shaker, Faris, additional, Abdulrazzak, Mohammad A, additional, Ray, Abhishek, additional, Sunshine, Jeffery, additional, Opaskar, Amanda, additional, Duncan, Kelsey R, additional, Xiong, Wei, additional, Al-Shaibi, Faisal K, additional, Samaniego, Edgar A, additional, Nguyen, Thanh N, additional, Fifi, Johanna T, additional, Tjoumakaris, Stavropoula I, additional, Jabbour, Pascal, additional, Mendes Pereira, Vitor, additional, Lansberg, Maarten G, additional, Sila, Cathy, additional, Bambakidis, Nicholas C, additional, Davis, Stephen, additional, Wechsler, Lawrence, additional, Albers, Gregory W, additional, Grotta, James C, additional, Ribo, Marc, additional, Hassan, Ameer E, additional, Campbell, Bruce, additional, Hill, Michael D, additional, and Sarraj, Amrou, additional

Published
2024
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9. Histological composition of retrieved emboli in acute ischemic stroke is independent of pre-thrombectomy alteplase use

Author

Brinjikji, Waleed, Abbasi, Mehdi, Mereuta, Oana Madalina, Fitzgerald, Seán, Larco, Jorge Arturo, Dai, Daying, Kadirvel, Ramanathan, Nogueira, Raul G., Kvamme, Peter, Layton, Kennith F., Delgado, Josser E., Hanel, Ricardo A., Pereira, Vitor M., Almekhlafi, Mohammed A., Yoo, Albert J., Jahromi, Babak S., Gounis, Matthew J., Patel, Biraj M., Savastano, Luis E., Cloft, Harry J., Haussen, Diogo C., Al-Bayati, Alhamza, Mohammaden, Mahmoud, Pisani, Leonardo, Rodrigues, Gabriel, Thacker, Ike C., Kayan, Yasha, Copelan, Alexander Z., Aghaebrahim, Amin, Sauvageau, Eric, Demchuk, Andrew M., Bhuva, Parita, Soomro, Jazba, Nazari, Pouya, Cantrell, Donald Robert, Puri, Ajit S., Doyle, Karen M., Entwistle, John, and Kallmes, David F.

Published
2022
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11. Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes after Acute Ischemic Stroke: An Analysis of the DAWN Trial.

Author

Nogueira, Raul G., Doheim, Mohamed F., Jadhav, Ashutosh P., Aghaebrahim, Amin, Frankel, Michael R., Jankowitz, Brian T., Budzik, Ronald F., Bonafe, Alain, Bhuva, Parita, Yavagal, Dileep R., Hanel, Ricardo A., Hassan, Ameer E., Ribo, Marc, Cognard, Christophe, Sila, Cathy A., Jenkins, Paul, Smith, Wade S., Saver, Jeffrey L., Liebeskind, David S., and Jovin, Tudor G.

Subjects
ISCHEMIC stroke, TREATMENT effectiveness, ENDOVASCULAR surgery, REPERFUSION, INTRACRANIAL hemorrhage
Abstract

Objective: We aimed to assess the impact of time to endovascular thrombectomy (EVT) on clinical outcomes in the DAWN trial, while also exploring the potential effect modification of mode of stroke onset on this relationship. Methods: The association between every 1‐h treatment delay with 90‐day functional independence (modified Rankin Scale [mRS] score 0–2), symptomatic intracranial hemorrhage, and 90‐day mortality was explored in the overall population and in three modes of onset subgroups (wake‐up vs. witnessed vs. unwitnessed). Results: Out of the 205 patients, 98 (47.8%) and 107 (52.2%) presented in the 6 to 12 hours and 12 to 24 hours time window, respectively. Considering all three modes of onset together, there was no statistically significant association between time last seen well to randomization with either functional independence or mortality at 90 days in either the endovascular thrombectomy (mRS 0–2 1‐hour delay OR 1.07; 95% CI 0.93–1.24; mRS 6 OR 0.84; 95% CI 0.65–1.03) or medical management (mRS 0–2 1‐hour delay OR 0.98; 95% CI 0.80–1.14; mRS 6 1‐hour delay OR 0.94; 95% CI 0.79–1.09) groups. Moreover, there was no significant interaction between treatment effect and time (p = 0.439 and p = 0.421 for mRS 0–2 and 6, respectively). However, within the thrombectomy group, the models that tested the association between time last seen well to successful reperfusion (modified Treatment in Cerebral Infarction ≥2b) and 90‐day functional independence showed a significant interaction with mode of presentation (p = 0.013). This appeared to be driven by a nominally positive slope for both witnessed and unwitnessed strokes versus a significantly (p = 0.018) negative slope in wake‐up patients. There was no association between treatment times and symptomatic intracranial hemorrhage. Interpretation: Mode of onset modifies the effect of time to reperfusion on thrombectomy outcomes, and should be considered when exploring different treatment paradigms in the extended window. ANN NEUROL 2024;96:356–364 [ABSTRACT FROM AUTHOR]

Published
2024
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12. Abstract WMP92: Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes After Acute Ischemic Stroke: An Analysis of the DAWN Trial

Author

Dohiem, Mohamed, primary, Jadhav, Ashutosh, additional, Aghaebrahim, Amin, additional, Frankel, Michael, additional, Jankowitz, Brian, additional, Budzik, Ronald, additional, Bonafe, Alain, additional, Bhuva, Parita, additional, Yavagal, Dileep R, additional, Hanel, Ricardo, additional, Hassan, Ameer E, additional, Ribo, Marc, additional, Cognard, Christophe, additional, Sila, Cathy, additional, Jenkins, Paul, additional, Morgan, Patricia M, additional, Smith, Wade, additional, Saver, Jeffrey, additional, Liebeskind, David S, additional, Jovin, Tudor, additional, Haussen, Diogo C, additional, and Nogueira, Raul G, additional

Published
2024
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15. Diffusion-weighted imaging lesions after intracranial aneurysm treatment with Pipeline Flex and Pipeline Flex with Shield technology: a retrospective cohort analysis.

Author

Cortez, Gustavo M., Benalia, Victor H. C., Sauvageau, Eric, Aghaebrahim, Amin, Pederson, John Michael, and Hanel, Ricardo A.

Subjects
INTRACRANIAL aneurysms, MEDICAL technology, THERAPEUTIC embolization, MULTIPLE regression analysis, MAGNETIC resonance imaging, RETROSPECTIVE studies, TREATMENT effectiveness, DESCRIPTIVE statistics, ODDS ratio, COMPARATIVE studies, CONFIDENCE intervals, FLUOROSCOPY, TIME
Abstract

Background The Pipeline Flex embolization device with Shield technology (PED Shield) is the first flow diverter for brain aneurysm treatment approved in the United States using surface-modified technology. The effect of PED Shield on decreasing perioperative diffusion-weighted imaging positive (DWI+) hits, as a marker for in-human decrease thrombogenicity, is unclear. Objective To determine if the number of periprocedural DWI+ lesions differs between patients with an aneurysm treated with PED Flex and PED Shield. Methods This retrospective study compares the outcomes of consecutive patients with an aneurysm treated with PED Flex and PED Shield. The primary outcome of interest was the occurrence of DWI+ lesions. We also assessed potential predictors of DWI+ lesions and compared the outcomes between on-label and off-label treatment indications. Results 89 patients were included, 48 (54%) treated with PED Flex and 41 (46%) with PED Shield. After matching, the incidence of DWI+ lesions was 61% and 62% for the PED Flex and PED Shield groups, respectively. Results were consistent across each model with no significant differences in DWI+ lesions between treatment groups, and effect sizes ranging from OR=1.08 (95% CI 0.41 to 2.89) after propensity score matching to OR=1.84 (95% CI 0.65 to 5.47) after multivariable regression. Multivariable models demonstrated reduced DWI+ lesions with balloon-assisted therapies and posterior circulation treatment, while a significant linear relationship was encountered with fluoroscopy time. Conclusion There was no significant difference in the incidence of perioperative DWI+ lesions between patients with an aneurysm treated with PED Flex and PED Shield. Larger cohorts are likely needed to demonstrate differences between the devices. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Anterior circulation location-specific results for stent-assisted coiling – carotid versus distal aneurysms: 1-year outcomes from the Neuroform Atlas Stent Pivotal Trial

Author

Hanel, Ricardo A, primary, Cortez, Gustavo M, additional, Jankowitz, Brian T, additional, Sauvageau, Eric, additional, Aghaebrahim, Amin, additional, Lin, Eugene, additional, Jadhav, Ashutosh P, additional, Gross, Bradley, additional, Khaldi, Ahmad, additional, Gupta, Rishi, additional, Frei, Donald, additional, Loy, David, additional, Price, Lori Lyn, additional, Hetts, Steven W, additional, and Zaidat, Osama O, additional

Published
2023
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18. Novel Tenzing 7 Delivery Catheter for Thrombectomy in Acute Stroke: A Clinical Multicenter Experience

Author

Tonetti, Daniel A., primary, Bhattacharyya, Meghna, additional, Koneru, Manisha, additional, English, Joey, additional, Settecase, Fabio, additional, Kim, Warren, additional, Patel, Pratit, additional, Thomas, Ajith, additional, Jovin, Tudor, additional, Hanel, Ricardo, additional, Benalia, Victor H.C., additional, Cortez, Gustavo M., additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, Abdalkader, Mohamad, additional, Nguyen, Thanh N., additional, Klein, Piers, additional, Dmytriw, Adam, additional, and Shaikh, Hamza A., additional

Published
2023
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19. Safety and Efficacy of Flow Diverters for Treatment of Unruptured Anterior Communicating Artery Aneurysms: Retrospective Multicenter Study

Author

Benalia, Victor H C, primary, Cortez, Gustavo M, additional, Mounayer, Charbel, additional, Saatci, Isil, additional, Cekirge, H Saruhan, additional, Kocer, Naci, additional, Islak, Civan, additional, Dabus, Guilherme, additional, Brinjikji, Waleed, additional, Baltacioglu, Feyyaz, additional, Pereira, Vitor M, additional, Nishi, Hidehisa, additional, Siddiqui, Adnan H, additional, Monteiro, Andre, additional, Lopes, Demetrius K, additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, and Hanel, Ricardo A, additional

Published
2023
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20. Rescue intracranial stenting for failed posterior circulation thrombectomy: analysis from the Stenting and Angioplasty in NeuroThrombectomy (SAINT) study

Author

Mohammaden, Mahmoud H, primary, Tarek, Mohamed A, additional, Aboul Nour, Hassan, additional, Haussen, Diogo C, additional, Fifi, Johanna T, additional, Matsoukas, Stavros, additional, Farooqui, Mudassir, additional, Ortega-Gutierrez, Santiago, additional, Zevallos, Cynthia B, additional, Galecio-Castillo, Milagros, additional, Hassan, Ameer E, additional, Tekle, Wondwossen, additional, Al-Bayati, Alhamza R, additional, Salem, Mohamed M, additional, Burkhardt, Jan Karl, additional, Pukenas, Bryan, additional, Cortez, Gustavo M, additional, Hanel, Ricardo A, additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, Hafeez, Muhammad, additional, Kan, Peter, additional, Tanweer, Omar, additional, Jumaa, Mouhammad, additional, Zaidi, Syed F, additional, Oliver, Marion, additional, Sheth, Sunil A, additional, Nahhas, Michael, additional, Salazar-Marioni, Sergio, additional, Khaldi, Ahmad, additional, Li, Hanzhou, additional, Kuybu, Okkes, additional, Abdalkader, Mohamad, additional, Klein, Piers, additional, Peng, Sophia, additional, Alaraj, Ali, additional, Nguyen, Thanh N, additional, and Nogueira, Raul G, additional

Published
2023
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21. Carotid Stenosis: Utility of Diagnostic Angiography

Author

Felbaum, Daniel R., Maxwell, Christina, Naydin, Stan, Ringer, Andrew, Hanel, Ricardo A., Sauvageau, Eric, Aghaebrahim, Amin, Aguilar-Salinas, Pedro, Veznedaroglu, Erol, Liebman, Kenneth, Hakma, Zakaria, Hedayat, Hirad, Kan, Peter, Srinivasan, Visish, and Binning, Mandy J.

Published
2019
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23. Thrombectomy Outcomes With General vs Nongeneral Anesthesia

Author

Sarraj, Amrou, Albers, Gregory W., Mitchell, Peter J., Hassan, Ameer E., Abraham, Michael G., Blackburn, Spiros, Sharma, Gagan, Yassi, Nawaf, Kleinig, Timothy J., Shah, Darshan G., Wu, Teddy Y., Hussain, Muhammad Shazam, Tekle, Wondwoseen G., Gutierrez, Santiago Ortega, Aghaebrahim, Amin Nima, Haussen, Diogo C., Toth, Gabor, Pujara, Deep, Budzik, Ronald F., Hicks, William, Vora, Nirav, Edgell, Randall C., Slavin, Sabreena, Lechtenberg, Colleen G., Maali, Laith, Qureshi, Abid, Rosterman, Lee, Abdulrazzak, Mohammad Ammar, AlMaghrabi, Tareq, Shaker, Faris, Mir, Osman, Arora, Ashish, Martin-Schild, Sheryl, Sitton, Clark W., Churilov, Leonid, Gupta, Rishi, Lansberg, Maarten G., Nogueira, Raul G., Grotta, James C., Donnan, Geoffrey Alan, Davis, Stephen M., and Campbell, Bruce C. V.

Subjects
Neurology (clinical), Research Article
Abstract

Background and ObjectivesThe effect of anesthesia choice on endovascular thrombectomy (EVT) outcomes is unclear. Collateral status on perfusion imaging may help identify the optimal anesthesia choice.MethodsIn a pooled patient-level analysis of EXTEND-IA, EXTEND-IA TNK, EXTEND-IA TNK part II, and SELECT, EVT functional outcomes (modified Rankin Scale score distribution) were compared between general anesthesia (GA) vs non-GA in a propensity-matched sample. Furthermore, we evaluated the association of collateral flow on perfusion imaging, assessed by hypoperfusion intensity ratio (HIR) – Tmax > 10 seconds/Tmax > 6 seconds (good collaterals – HIR < 0.4, poor collaterals – HIR ≥ 0.4) on the association between anesthesia type and EVT outcomes.ResultsOf 725 treated with EVT, 299 (41%) received GA and 426 (59%) non-GA. The baseline characteristics differed in presentation National Institutes of Health Stroke Scale score (median [interquartile range] GA: 18 [13–22], non-GA: 16 [11–20],p< 0.001) and ischemic core volume (GA: 15.0 mL [3.2–38.0] vs non-GA: 9.0 mL [0.0–31.0],p< 0.001). In addition, GA was associated with longer last known well to arterial access (203 minutes [157–267] vs 186 minutes [138–252],p= 0.002), but similar procedural time (35.5 minutes [23–59] vs 34 minutes [22–54],p= 0.51). Of 182 matched pairs using propensity scores, baseline characteristics were similar. In the propensity score–matched pairs, GA was independently associated with worse functional outcomes (adjusted common odds ratio [adj. cOR]: 0.64, 95% CI: 0.44–0.93,p= 0.021) and higher neurologic worsening (GA: 14.9% vs non-GA: 8.9%, aOR: 2.10, 95% CI: 1.02–4.33,p= 0.045). Patients with poor collaterals had worse functional outcomes with GA (adj. cOR: 0.47, 95% CI: 0.29–0.76,p= 0.002), whereas no difference was observed in those with good collaterals (adj. cOR: 0.93, 95% CI: 0.50–1.74,p= 0.82),pinteraction: 0.07. No difference was observed in infarct growth overall and in patients with good collaterals, whereas patients with poor collaterals demonstrated larger infarct growth with GA with a significant interaction between collaterals and anesthesia type on infarct growth rate (pinteraction: 0.020).DiscussionGA was associated with worse functional outcomes after EVT, particularly in patients with poor collaterals in a propensity score–matched analysis from a pooled patient-level cohort from 3 randomized trials and 1 prospective cohort study. The confounding by indication may persist despite the doubly robust nature of the analysis. These findings have implications for randomized trials of GA vs non-GA and may be of utility for clinicians when making anesthesia type choice.Classification of EvidenceThis study provides Class III evidence that use of GA is associated with worse functional outcome in patients undergoing EVT.Trial Registration InformationEXTEND-IA: ClinicalTrials.gov (NCT01492725); EXTEND-IA TNK: ClinicalTrials.gov (NCT02388061); EXTEND-IA TNK part II: ClinicalTrials.gov (NCT03340493); and SELECT: ClinicalTrials.gov (NCT02446587).

Published
2022

24. Push and Fluff technique for optimization of clot integration with stent-retriever: An in vitro model

Author

Pinheiro, Agostinho C., primary, Nogueira, Raul G., additional, Grandfield, Ryan M., additional, Lin, Shao-Pow, additional, Majjhoo, Aniel Q., additional, Aghaebrahim, Amin Nima, additional, Abraham, Michael G., additional, Mazaris, Paul, additional, Singer, Justin A., additional, Al-Bayati, Alhamza R., additional, Verhey, Leonard H., additional, Lin, Eugene, additional, and Haussen, Diogo C., additional

Published
2023
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26. Factors Associated With Improved Technical Outcomes When Using 0.068‐ to 0.074‐Inch Aspiration Catheters: Analysis From a Multicenter Retrospective Cohort

Author

Vargas, Jan, primary, Majidi, Shahram, additional, Hawk, Harris, additional, Nimjee, Shahid, additional, Zakeri, Amanda S., additional, Mokin, Maxim, additional, Kellogg, Ryan T, additional, Cortez, Gustavo, additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, Hanel, Ricardo, additional, DeLeacy, Reade, additional, Siddiqui, Adnan, additional, Oselkin, Martin, additional, Marlin, Evan, additional, Turner, Ray, additional, Chaudry, Imran, additional, and Milburn, James, additional

Published
2023
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27. Trial of Endovascular Thrombectomy for Large Ischemic Strokes

Author

Sarraj, Amrou, primary, Hassan, Ameer E., additional, Abraham, Michael G., additional, Ortega-Gutierrez, Santiago, additional, Kasner, Scott E., additional, Hussain, M. Shazam, additional, Chen, Michael, additional, Blackburn, Spiros, additional, Sitton, Clark W., additional, Churilov, Leonid, additional, Sundararajan, Sophia, additional, Hu, Yin C., additional, Herial, Nabeel A., additional, Jabbour, Pascal, additional, Gibson, Daniel, additional, Wallace, Adam N., additional, Arenillas, Juan F., additional, Tsai, Jenny P., additional, Budzik, Ronald F., additional, Hicks, William J., additional, Kozak, Osman, additional, Yan, Bernard, additional, Cordato, Dennis J., additional, Manning, Nathan W., additional, Parsons, Mark W., additional, Hanel, Ricardo A., additional, Aghaebrahim, Amin N., additional, Wu, Teddy Y., additional, Cardona-Portela, Pere, additional, Pérez de la Ossa, Natalia, additional, Schaafsma, Joanna D., additional, Blasco, Jordi, additional, Sangha, Navdeep, additional, Warach, Steven, additional, Gandhi, Chirag D., additional, Kleinig, Timothy J., additional, Sahlein, Daniel, additional, Elijovich, Lucas, additional, Tekle, Wondwossen, additional, Samaniego, Edgar A., additional, Maali, Laith, additional, Abdulrazzak, M. Ammar, additional, Psychogios, Marios N., additional, Shuaib, Ashfaq, additional, Pujara, Deep K., additional, Shaker, Faris, additional, Johns, Hannah, additional, Sharma, Gagan, additional, Yogendrakumar, Vignan, additional, Ng, Felix C., additional, Rahbar, Mohammad H., additional, Cai, Chunyan, additional, Lavori, Philip, additional, Hamilton, Scott, additional, Nguyen, Thanh, additional, Fifi, Johanna T., additional, Davis, Stephen, additional, Wechsler, Lawrence, additional, Pereira, Vitor M., additional, Lansberg, Maarten G., additional, Hill, Michael D., additional, Grotta, James C., additional, Ribo, Marc, additional, Campbell, Bruce C., additional, and Albers, Gregory W., additional

Published
2023
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28. 315 Use of Flow Diverter in the Treatment of Anterior Communicating Artery Aneurysms: A Multicenter Experience (FEAR ME study)

Author

Benalia, Victor, primary, Cortez, Gustavo, additional, Mounayer, Charbel, additional, Saatci, Isil, additional, Cekirge, Saruhan, additional, Koçer, Nací, additional, Islak, Civan, additional, Dabus, Guilherme, additional, Brinjikji, Waleed, additional, Baltacıoğlu, Feyyaz, additional, Pereira, Vitor Mendes, additional, Nishi, Hidehisa, additional, Siddiqui, Adnan, additional, Lopes, Demetrius K., additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, and Hanel, Ricardo A., additional

Published
2023
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30. Abstract Number ‐ 37: A Clinical Multicenter Experience of Novel Tenzing Delivery Catheter for Thrombectomy in Acute Stroke

Author

Bhattacharyya, Meghna, primary, Koneru, Manisha, additional, Shaikh, Hamza, additional, Patel, Pratit, additional, Thomas, Ajith, additional, Tonetti, Daniel, additional, Abdalkader, Mohamad, additional, Nguyen, Thanh, additional, Klein, Piers, additional, Hanel, Ricardo A, additional, Benalia, Victor H, additional, Cortez, Gustavo M, additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, and Dmytriw, Adam, additional

Published
2023
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31. Clot composition and recanalization outcomes in mechanical thrombectomy

Author

Nogueira, Raul G, Pinheiro, Agostinho, Brinjikji, Waleed, Abbasi, Mehdi, Al-Bayati, Alhamza R, Mohammaden, Mahmoud H, Souza Viana, Lorena, Ferreira, Felipe, Abdelhamid, Hend, Bhatt, Nirav R, Kvamme, Peter, Layton, Kennith F, Delgado Almandoz, Josser E, Hanel, Ricardo A, Mendes Pereira, Vitor, Almekhlafi, Mohammed A, Yoo, Albert J, Jahromi, Babak S, Gounis, Matthew J, Patel, Biraj, Arturo Larco, Jorge L, Fitzgerald, Sean, Mereuta, Oana Madalina, Doyle, Karen, Savastano, Luis E, Cloft, Harry J, Thacker, Ike C, Kayan, Yasha, Copelan, Alexander, Aghaebrahim, Amin, Sauvageau, Eric, Demchuk, Andrew M, Bhuva, Parita, Soomro, Jazba, Nazari, Pouya, Cantrell, Donald Robert, Puri, Ajit S, Entwistle, John, Polley, Eric C, Frankel, Michael R, Kallmes, David F, and Haussen, Diogo C

Abstract

BackgroundMechanical thrombectomy (MT) has become standard for large vessel occlusions, but rates of complete recanalization are suboptimal. Previous reports correlated radiographic signs with clot composition and a better response to specific techniques. Therefore, understanding clot composition may allow improved outcomes.MethodsClinical, imaging, and clot data from patients enrolled in the STRIP Registry from September 2016 to September 2020 were analyzed. Samples were fixed in 10% phosphate-buffered formalin and stained with hematoxylin-eosin and Martius Scarlett Blue. Percent composition, richness, and gross appearance were evaluated. Outcome measures included the rate of first-pass effect (FPE, modified Thrombolysis in Cerebral Infarction 2c/3) and the number of passes.ResultsA total of 1430 patients of mean±SD age 68.4±13.5 years (median (IQR) baseline National Institutes of Health Stroke Scale score 17.2 (10.5–23), IV-tPA use 36%, stent-retrievers (SR) 27%, contact aspiration (CA) 27%, combined SR+CA 43%) were included. The median (IQR) number of passes was 1 (1–2). FPE was achieved in 39.3% of the cases. There was no association between percent histological composition or clot richness and FPE in the overall population. However, the combined technique resulted in lower FPE rates for red blood cell (RBC)-rich (P<0.0001), platelet-rich (P=0.003), and mixed (P<0.0001) clots. Fibrin-rich and platelet-rich clots required a higher number of passes than RBC-rich and mixed clots (median 2 and 1.5 vs 1, respectively; P=0.02). CA showed a trend towards a higher number of passes with fibrin-rich clots (2 vs 1; P=0.12). By gross appearance, mixed/heterogeneous clots had lower FPE rates than red and white clots.ConclusionsDespite the lack of correlation between clot histology and FPE, our study adds to the growing evidence supporting the notion that clot composition influences recanalization treatment strategy outcomes.

Published
2024
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32. General anesthesia vs procedural sedation for failed NeuroThrombectomy undergoing rescue stenting: intention to treat analysis.

Author

Mohammaden, Mahmoud H., Haussen, Diogo C., Al-Bayati, Alhamza R., Hassan, Ameer E., Tekle, Wondwossen, Fifi, Johanna T., Matsoukas, Stavros, Kuybu, Okkes, Gross, Bradley A., Lang, Michael, Narayanan, Sandra, Cortez, Gustavo M., Hanel, Ricardo A., Aghaebrahim, Amin, Sauvageau, Eric, Farooqui, Mudassir, Ortega-Gutierrez, Santiago, Zevallos, Cynthia B., Galecio-Castillo, Milagros, and Sheth, Sunil A.

Subjects
SKULL surgery, GENERAL anesthesia, ANESTHESIA, NEUROSURGERY, INTRACRANIAL hemorrhage, MORTALITY, SURGICAL stents, SURGERY, PATIENTS, TREATMENT failure, TREATMENT effectiveness, FUNCTIONAL assessment, THROMBECTOMY, REPERFUSION, PATIENT safety, CEREBRAL arteriosclerosis, ANGIOPLASTY, PROBABILITY theory, EVALUATION
Abstract

Background There is little data available to guide optimal anesthesia management during rescue intracranial angioplasty and stenting (ICAS) for failed mechanical thrombectomy (MT). We sought to compare the procedural safety and functional outcomes of patients undergoing rescue ICAS for failed MT under general anesthesia (GA) vs non-general anesthesia (non-GA). Methods We searched the data from the Stenting and Angioplasty In Neuro Thrombectomy (SAINT) study. In our review we included patients if they had anterior circulation large vessel occlusion strokes due to intracranial internal carotid artery (ICA) or middle cerebral artery (MCA-M1/M2) segments, failed MT, and underwent rescue ICAS. The cohort was divided into two groups: GA and non-GA. We used propensity score matching to balance the two groups. The primary outcome was the shift in the degree of disability as measured by the modified Rankin Scale (mRS) at 90 days. Secondary outcomes included functional independence (90-day mRS0-2) and successful reperfusion defined as mTICI2B-3. Safety measures included symptomatic intracranial hemorrhage (sICH) and 90-day mortality. Results Among 253 patients who underwent rescue ICAS, 156 qualified for the matching analysis at a 1:1 ratio. Baseline demographic and clinical characteristics were balanced between both groups. Non-GA patients had comparable outcomes to GA patients both in terms of the overall degree of disability (mRS ordinal shift; adjusted common odds ratio 1.29, 95% CI [0.69 to 2.43], P=0.43) and rates of functional independence (33.3% vs 28.6%, adjusted odds ratio 1.32, 95% CI [0.51 to 3.41], P=0.56) at 90 days. Likewise, there were no significant differences in rates of successful reperfusion, sICH, procedural complications or 90-day mortality among both groups. Conclusions Non- GA seems to be a safe and effective anesthesia strategy for patients undergoing rescue ICAS after failed MT. Larger prospective studies are warranted for more concrete evidence. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Abstract 99: Clot Composition And Reperfusion Outcomes In 1430 Mechanical Thrombectomy Patients: Analysis Of The Stroke Thromboembolism Registry Of Imaging And Pathology

Author

Nogueira, Raul G, primary, Pinheiro, Agostinho, additional, Brinjikji, Waleed, additional, Abbasi, Mehdi, additional, Al-Bayati, Alhamza R, additional, Mohammaden, Mahmoud, additional, Viana, Lorena S, additional, Ferreira, Felipe, additional, Abdelhamid, Hend M, additional, Bhatt, Nirav, additional, Kvamme, Peter, additional, Layton, Kennith, additional, Delgado Almandoz, Josser, additional, Hanel, Ricardo, additional, Mendes Pereira, Vitor, additional, Almekhlafi, Mohammed, additional, Yoo, Albert J, additional, Jahromi, Babak S, additional, Gounis, Matthew J, additional, Patel, Biraj M, additional, Arturo Larco, Jorge, additional, Fitzgerald, Sean, additional, Mereuta, Oana M, additional, Doyle, Karen, additional, Savastano, Luis, additional, Cloft, Harry J, additional, Thacker, Ike, additional, Kayan, Yasha, additional, Copelan, Alexander, additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, Demchuk, Andrew M, additional, Bhuva, Parita, additional, Soomro, Jazba, additional, Nazari, Pouya, additional, Cantrell, Donald, additional, Puri, Ajit S, additional, Entwistle, John, additional, Polley, Eric C, additional, Frankel, Michael R, additional, Kallmes, David F, additional, and Haussen, Diogo C, additional

Published
2023
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34. Abstract 24: Primary Results Of The Preset For Occlusive Stroke Treatment (prost) Randomized Clinical Trial

Author

Nogueira, Raul G, primary, Hanel, Ricardo, additional, Klisch, Joachim, additional, Moehlenbruch, Markus, additional, Bozorgchami, Hormozd, additional, Samaniego, Edgar A, additional, Liebeskind, David S, additional, Lobsien, Donald, additional, Pielenz, Daniel, additional, Sauvageau, Eric, additional, Aghaebrahim, Amin N, additional, Clark, Wayne M, additional, Priest, Ryan, additional, Ortega-Gutierrez, Santiago, additional, Lopes, Demetrius, additional, Billingsley, Joshua, additional, Haussen, Diogo C, additional, Al-Bayati, Alhamza R, additional, Siddiqui, Adnan H, additional, Chen, Michael, additional, Schramm, Peter, additional, Narayanan, Sandra, additional, Roth, Christian, additional, Boeckh-Behrens, Tobias, additional, Hassan, Ameer E, additional, Fifi, Johanna T, additional, Budzik, Ronald, additional, Tarpley, Jason W, additional, Starke, Robert, additional, and Raz, Eytan, additional

Published
2023
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35. General anesthesia vs procedural sedation for failed NeuroThrombectomy undergoing rescue stenting: intention to treat analysis

Author

Mohammaden, Mahmoud H, primary, Haussen, Diogo C, additional, Al-Bayati, Alhamza R, additional, Hassan, Ameer E, additional, Tekle, Wondwossen, additional, Fifi, Johanna T, additional, Matsoukas, Stavros, additional, Kuybu, Okkes, additional, Gross, Bradley A, additional, Lang, Michael, additional, Narayanan, Sandra, additional, Cortez, Gustavo M, additional, Hanel, Ricardo A, additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, Farooqui, Mudassir, additional, Ortega-Gutierrez, Santiago, additional, Zevallos, Cynthia B, additional, Galecio-Castillo, Milagros, additional, Sheth, Sunil A, additional, Nahhas, Michael, additional, Salazar-Marioni, Sergio, additional, Nguyen, Thanh N, additional, Abdalkader, Mohamad, additional, Klein, Piers, additional, Hafeez, Muhammad, additional, Kan, Peter, additional, Tanweer, Omar, additional, Khaldi, Ahmad, additional, Li, Hanzhou, additional, Jumaa, Mouhammad, additional, Zaidi, Syed F, additional, Oliver, Marion, additional, Salem, Mohamed, additional, Burkhardt, Jan-Karl, additional, Pukenas, Bryan, additional, Kumar, Rahul, additional, Lai, Michael, additional, Siegler, James E, additional, Peng, Sophia, additional, Alaraj, Ali, additional, and Nogueira, Raul G, additional

Published
2022
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37. sj-docx-1-ine-10.1177_15910199231175348 - Supplemental material for Push and Fluff technique for optimization of clot integration with stent-retriever: An in vitro model

Author

Pinheiro, Agostinho C., Nogueira, Raul G., Grandfield, Ryan M., Lin, Shao-Pow, Majjhoo, Aniel Q., Aghaebrahim, Amin Nima, Abraham, Michael G., Mazaris, Paul, Singer, Justin A., Al-Bayati, Alhamza R., Verhey, Leonard H., Lin, Eugene, and Haussen, Diogo C.

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-ine-10.1177_15910199231175348 for Push and Fluff technique for optimization of clot integration with stent-retriever: An in vitro model by Agostinho C. Pinheiro, Raul G. Nogueira, Ryan M. Grandfield, Shao-Pow Lin, Aniel Q. Majjhoo, Amin Nima Aghaebrahim, Michael G. Abraham, Paul Mazaris, Justin A. Singer, Alhamza R. Al-Bayati, Leonard H. Verhey, Eugene Lin and Diogo C. Haussen in Interventional Neuroradiology

Published
2023
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38. Outcome in Direct Versus Transfer Patients in the DAWN Controlled Trial

Author

Aghaebrahim, Amin, Jadhav, Ashutosh P., Hanel, Ricardo, Sauvageau, Eric, Granja, Manuel F., Zhang, Yanchang, Haussen, Diogo C., Budzik, Ronald F., Bonafe, Alain, Bhuva, Parita, Ribo, Marc, Cognard, Christophe, Sila, Cathy, Yavagal, Dileep, Hassan, Ameer E., Smith, Wade S., Saver, Jeffrey, Liebeskind, David S., Nogueira, Raul G., and Jovin, Tudor G.

Published
2019
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39. Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source

Author

Fitzgerald, Seán, Dai, Daying, Wang, Shunli, Douglas, Andrew, Kadirvel, Ramanathan, Layton, Kennith F., Thacker, Ike C., Gounis, Matthew J., Chueh, Ju-Yu, Puri, Ajit S., Almekhlafi, Mohammed, Demchuk, Andrew M., Hanel, Ricardo A., Sauvageau, Eric, Aghaebrahim, Amin, Yoo, Albert J., Kvamme, Peter, M. Pereira, Vitor, Kayan, Yasha, Delgado Almandoz, Josser E., Nogueira, Raul G., Rabinstein, Alejandro A., Kallmes, David F., Doyle, Karen M., and Brinjikji, Waleed

Published
2019
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40. Contributors

Author

Abecassis, Isaac J., primary, Abruzzo, Todd A., additional, Adel, Joseph G., additional, Aghaebrahim, Amin, additional, Aguilar-Salinas, Pedro, additional, Alimi, Marjan, additional, Aljuboori, Zaid S., additional, Andaluz, Norberto O., additional, Arthur, Adam S., additional, Babadjouni, Robin, additional, Batjer, H. Hunt, additional, Bhambri, Ankur, additional, Binning, Mandy J., additional, Boulos, Alan S., additional, Brasiliense, Leonardo B.C., additional, Brinjikji, Waleed, additional, Carroll, Christopher P., additional, Cheema, Ahmed, additional, Chen, Stephen R., additional, Cherian, Jacob, additional, Cheung, Vincent, additional, Colon, Nathan L., additional, Dalfino, John C., additional, de Oliveira Sillero, Rafael, additional, Dieppa, David S., additional, Effendi, Sabih T., additional, Elwood, Adam, additional, Fargen, Kyle M., additional, Fennell, Vernard S., additional, Fessler, Richard D., additional, Fortuny, Enzo S., additional, Galarza-Paez, Laura, additional, Reid Gooch, M., additional, Gopakumar, Sricharan, additional, Goyal, Nitin, additional, Greenberg, Karen, additional, Griessenauer, Christoph J., additional, Gupta, Vivek, additional, Hanel, Ricardo A., additional, Hamm, Carman Wayne, additional, Hedayat, Hirad S., additional, Hoit, Daniel, additional, Howington, Jay U., additional, James, Robert F., additional, Janjua, Rashid M., additional, Jimenez, Lincoln, additional, Kan, Peter, additional, Khalessi, Alexander, additional, Khan, Usman A., additional, Khattar, Nicolas K., additional, Kim, Louis J., additional, Langer, David J., additional, Lanzino, Giuseppe, additional, Levitt, Michael R., additional, Levy, Elad I., additional, Liebman, Kenneth, additional, Lodi, Yahia M., additional, Mack, William J., additional, Mascitelli, Justin, additional, Mehta, Nikhil, additional, Moore, Kenneth A., additional, Mejia Munne, Juan C., additional, Nickele, Christopher, additional, Obiora, Jeffrey C., additional, Adam Oliver, Thomas, additional, Palma, Atilio, additional, Pandey, Aditya S., additional, Pannell, Jeffrey S., additional, Patel, Maunik, additional, Pollock, Glenn, additional, Rahman, Syed A., additional, Rahme, Ralph, additional, Rennert, Robert C., additional, Ringer, Andrew J., additional, Santos, Roberta, additional, Sauvageau, Eric, additional, Savastano, Luis E., additional, Schirmer, Clemens M., additional, Serrone, Joseph C., additional, Siddiqui, Adnan H., additional, Singh, Jasmeet, additional, Spiotta, Alejandro M., additional, Srinivasan, Visish M., additional, Starke, Robert, additional, Steinberg, Jeffrey A., additional, Stofko, Douglas L., additional, Sudhakar, Tejaswi D., additional, Tackla, Ryan D., additional, Thomas, Justin G., additional, Turner, Raymond D., additional, Vargas, Jan, additional, Veznedaroglu, Erol, additional, Vibhute, Prasanna, additional, Vuong, Shawn M., additional, Walcott, Brian P., additional, Wali, Arvin R., additional, Welch, Babu G., additional, White, Andrew C., additional, White, Jonathan A., additional, White, Timothy G., additional, Wicks, Robert T., additional, Andrew Wilkinson, David, additional, Wilson, John A., additional, Wolfe, Stacey Q., additional, Yamamoto, Junichi, additional, Yim, Benjamin, additional, and Young, Christopher C., additional

Published
2018
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42. Endovascular Therapy vs Medical Management for Patients With Acute Stroke With Medium Vessel Occlusion in the Anterior Circulation

Author

Saber, Hamidreza, primary, Desai, Shashvat M., additional, Haussen, Diogo, additional, Al-bayati, Alhamza, additional, Majidi, Shahram, additional, Mocco, J., additional, Hassan, Ameer E., additional, Rajah, Gary, additional, Waqas, Muhammad, additional, Davies, Jason M., additional, Dornbos, David, additional, Nickele, Christopher, additional, Arthur, Adam S., additional, Mowla, Ashkan, additional, Tenser, Matthew S., additional, Mokin, Maxim, additional, Pressman, Elliot, additional, Aghaebrahim, Amin, additional, Hanel, Ricardo A., additional, Ortega-Gutierrez, Santiago, additional, Jovin, Tudor, additional, Duckwiler, Gary R., additional, Liebeskind, David S., additional, Nogueira, Raul G., additional, Gornbein, Jeffrey, additional, Saver, Jeffrey L., additional, and Jadhav, Ashutosh P., additional

Published
2022
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44. Stenting and Angioplasty in Neurothrombectomy: Matched Analysis of Rescue Intracranial Stenting Versus Failed Thrombectomy

Author

Mohammaden, Mahmoud H., primary, Haussen, Diogo C., additional, Al-Bayati, Alhamza R., additional, Hassan, Ameer, additional, Tekle, Wondwossen, additional, Fifi, Johanna, additional, Matsoukas, Stavros, additional, Kuybu, Okkes, additional, Gross, Bradley A., additional, Lang, Michael J., additional, Narayanan, Sandra, additional, Cortez, Gustavo M., additional, Hanel, Ricardo A., additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, Farooqui, Mudassir, additional, Ortega-Gutierrez, Santiago, additional, Zevallos, Cynthia, additional, Galecio-Castillo, Milagros, additional, Sheth, Sunil A., additional, Nahhas, Michael, additional, Salazar-Marioni, Sergio, additional, Nguyen, Thanh N., additional, Abdalkader, Mohamad, additional, Klein, Piers, additional, Hafeez, Muhammad, additional, Kan, Peter, additional, Tanweer, Omar, additional, Khaldi, Ahmad, additional, Li, Hanzhou, additional, Jumaa, Mouhammad, additional, Zaidi, Syed, additional, Oliver, Marion, additional, Salem, Mohamed M., additional, Burkhardt, Jan-Karl, additional, Pukenas, Bryan A., additional, Alaraj, Ali, additional, Peng, Sophia, additional, Kumar, Rahul, additional, Lai, Michael, additional, Siegler, James, additional, and Nogueira, Raul G., additional

Published
2022
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46. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

Author

Nogueira, Raul G., Jadhav, Ashutosh P., Haussen, Diogo C., Bonafe, Alain, Budzik, Ronald F., Bhuva, Parita, Yavagal, Dileep R., Ribo, Marc, Cognard, Christophe, Hanel, Ricardo A., Sila, Cathy A., Hassan, Ameer E., Millan, Monica, Levy, Elad I., Mitchell, Peter, Chen, Michael, English, Joey D., Shah, Qaisar A., Silver, Frank L., Pereira, Vitor M., Mehta, Brijesh P., Baxter, Blaise W., Abraham, Michael G., Cardona, Pedro, Veznedaroglu, Erol, Hellinger, Frank R., Feng, Lei, Kirmani, Jawad F., Lopes, Demetrius K., Jankowitz, Brian T., Frankel, Michael R., Costalat, Vincent, Vora, Nirav A., Yoo, Albert J., Malik, Amer M., Furlan, Anthony J., Rubiera, Marta, Aghaebrahim, Amin, Olivot, Jean-Marc, Tekle, Wondwossen G., Shields, Ryan, Graves, Todd, Lewis, Roger J., Smith, Wade S., Liebeskind, David S., Saver, Jeffrey L., and Jovin, Tudor G.

Published
2018
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48. Correlation of von Willebrand factor and platelets with acute ischemic stroke etiology and revascularization outcome: an immunohistochemical study.

Author

Mereuta, Oana Madalina, Abbasi, Mehdi, Arturo Larco, Jorge L., Daying Dai, Yang Liu, Arul, Santhosh, Kadirvel, Ramanathan, Hanel, Ricardo A., Yoo, Albert J., Almekhlafi, Mohammed A., Layton, Kennith F., Delgado Almandoz, Josser E., Kvamme, Peter, Mendes Pereira, Vitor, Jahromi, Babak S., Nogueira, Raul G., Gounis, Matthew J., Patel, Biraj, Aghaebrahim, Amin, and Sauvageau, Eric

Subjects
RESEARCH, STAINS & staining (Microscopy), BLOOD platelets, ISCHEMIC stroke, REVASCULARIZATION (Surgery), IMMUNOHISTOCHEMISTRY, GENETIC disorders, TREATMENT effectiveness, T-test (Statistics), BLOOD coagulation disorders, CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, STATISTICAL correlation, DISEASE risk factors
Abstract

Background Platelets and von Willebrand factor (vWF) are key components of acute ischemic stroke (AIS) emboli. We aimed to investigate the CD42b (platelets)/ vWF expression, its association with stroke etiology and the impact these components may have on the clinical/ procedural parameters. Methods CD42b/vWF immunostaining was performed on 288 emboli collected as part of the multicenter STRIP Registry. CD42b/VWF expression and distribution were evaluated. Student's t-test and χ² test were performed as appropriate. Results The mean CD42b and VWF content in clots was 44.3% and 21.9%, respectively. There was a positive correlation between platelets and vWF (r=0.64, p<0.001**). We found a significantly higher vWF level in the other determined etiology (p=0.016*) and cryptogenic (p=0.049*) groups compared with cardioembolic etiology. No significant difference in CD42b content was found across the etiology subtypes. CD42b/vWF patterns were significantly associated with stroke etiology (p=0.006*). The peripheral pattern was predominant in atherosclerotic clots (36.4%) while the clustering (patchy) pattern was significantly associated with cardioembolic and cryptogenic origin (66.7% and 49.8%, respectively). The clots corresponding to other determined etiology showed mainly a diffuse pattern (28.1%). Two types of platelets were distinguished within the CD42b-positive clusters in all emboli: vWF-positive platelets were observed at the center, surrounded by vWF-negative platelets. Thrombolysis correlated with a high platelet content (p=0.03*). vWF-poor and peripheral CD42b/vWF pattern correlated with first pass effect (p=0.03* and p=0.04*, respectively). Conclusions The vWF level and CD42b/vWF distribution pattern in emboli were correlated with AIS etiology and revascularization outcome. Platelet content was associated with response to thrombolysis. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Correlation of von Willebrand factor and platelets with acute ischemic stroke etiology and revascularization outcome: an immunohistochemical study

Author

Mereuta, Oana Madalina, primary, Abbasi, Mehdi, additional, Arturo Larco, Jorge L, additional, Dai, Daying, additional, Liu, Yang, additional, Arul, Santhosh, additional, Kadirvel, Ramanathan, additional, Hanel, Ricardo A, additional, Yoo, Albert J, additional, Almekhlafi, Mohammed A, additional, Layton, Kennith F, additional, Delgado Almandoz, Josser E, additional, Kvamme, Peter, additional, Mendes Pereira, Vitor, additional, Jahromi, Babak S, additional, Nogueira, Raul G, additional, Gounis, Matthew J, additional, Patel, Biraj, additional, Aghaebrahim, Amin, additional, Sauvageau, Eric, additional, Bhuva, Parita, additional, Soomro, Jazba, additional, Demchuk, Andrew M, additional, Thacker, Ike C, additional, Kayan, Yasha, additional, Copelan, Alexander, additional, Nazari, Pouya, additional, Cantrell, Donald Robert, additional, Haussen, Diogo C, additional, Al-Bayati, Alhamza R, additional, Mohammaden, Mahmoud, additional, Pisani, Leonardo, additional, Rodrigues, Gabriel Martins, additional, Puri, Ajit S, additional, Entwistle, John, additional, Meves, Alexander, additional, Savastano, Luis, additional, Cloft, Harry J, additional, Nimjee, Shahid M, additional, McBane II, Robert D, additional, Kallmes, David F, additional, and Brinjikji, Waleed, additional

Published
2022
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