23 results on '"Agneta G"'
Search Results
2. Abstract 12070: Extracellular Vesicles, Derived Early After Myocardial Infarction, Inhibits Staurosporin Induced Cardiac Cell Death
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Avinash Khandagale, Bertil Lindahl, Agneta G Siegbahn, and Christina Christersson
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Introduction: Adverse ventricular remodeling may occur after myocardial infarction (MI) and is associated with an increased risk of heart failure and death. Extracellular vesicles (EVs) derived exogenously from pluripotent stem cells exert cardioprotective effects after injury and being tested for therapeutic efficacy for MI. However role of endogenous EVs from MI patients in this regard is not yet addressed. Hypothesis: We aim to characterize EVs derived from MI patients and explore their cardioprotective potential on human primary cardiomyocytes (HCM) upon chemically induced cell death. Methods: The EVs from plasma of MI patients with preserved or reduced left ventricular ejection fraction (LVEF) and healthy controls (HC) were purified and characterized by flow cytometry and transmission electron microscopy (TEM). HCM and human cardiac microvascular endothelial cells (hCMVECs) were used to study functional effects of EVs upon staurosporin (STS), etoposide and rapamycin induced cell death. Results: Higher concentrations of platelet-, leukocyte-, endothelial- and erythrocyte-derived EVs were found in MI patients compared to HC. TEM analysis demonstrated the presence of heterogenous vesicles of different sizes (50-1000-nm) across all tested samples. Human cardiac cells- hCMVECs and HCM when pre-incubated with both preserved and reduced LVEF MI EVs showed significant attenuation to STS-induced caspase 3 activity compared to HC EVs or mock treatment. Lactate dehydrogenase (LDH) release, as a marker for membrane integrity, upon etoposide stimulation was not affected in hCMVECs and partly increased in HCM, whereas pre-incubation with HC EVs or MI EVs did not affect eotoposide treatment outcome by these cells. While rapamycin induced cleavage of LC3-I to LC3-II in hCMVECs, the presence of EVs from either HC or MI patients did not influence autophagic response. Whereas, baseline LC3-II expression in HCM was observed to be too high to be perturbed by the presence of rapamycin. Conclusions: Diverse nature of MI EVs in terms of cells of origin can be further elaborated to consolidate their biomarker potential. Cardioprotective ability of endogenously presented heterogenous mixture of MI EVs opens new avenues to consider in preclinical EV/MI research.
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- 2021
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3. Abstract 10162: NT-proBNP is Associated with Stroke, Heart Failure Hospitalizations, and Death in Patients with Atrial Fibrillation Without Oral Anticoagulation Regardless of Heart Rhythm
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Maria Tomasdottir, Ziad Hijazi, Johan Lindback, Alexander Benz, Stuart J Connolly, John W Eikelboom, Agneta G Siegbahn, Lars C Wallentin, and Jonas Oldgren
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Background: NT-proBNP is elevated in patients with a diagnosis of atrial fibrillation (AF) and associated with risk of stroke and other outcomes. The associations have mainly been studied in patients on oral anticoagulation and not considering if samples were obtained during AF or sinus rhythm. We investigated the association of NT-proBNP with heart rhythm and cardiovascular (CV) events in patients with AF without oral anticoagulation. Methods: Plasma samples were obtained at baseline in 3184 patients with diagnosis of AF (2142 in AF rhythm at blood sampling) receiving aspirin in two multicenter randomized clinical trials with median follow-up 1.2 years (AVERROES) and 3.8 years (ACTIVE A), respectively. NT-proBNP was analyzed using Elecsys electrochemiluminescence immunoassay. Association of NT-proBNP with clinical variables was assessed with multivariable linear regression models. Association with outcomes were estimated with Cox-regression models adjusting for clinical variables. Results: Median age was 71 years, 57.8% were men, and median NT-proBNP 713 ng/L (25 th -75 th percentiles, 282-1388 ng/L). Variables contributing to NT-proBNP level were, in reducing order: AF rhythm (ratio of geometric means 2.9), age, creatinine, and prior heart failure. Levels of NT-proBNP were significantly associated with ischemic stroke (HR 3 rd vs 1 st quartile 2.1, 95%CI 1.5-3.0), heart failure hospitalizations (HR 2.2, 95%CI 1.6-2.9), and CV death (HR 2.4, 95% CI 1.8-3.3), all p Conclusion: In patients with a diagnosis AF, plasma levels of NT-proBNP are three times higher during AF rhythm compared with sinus rhythm. Higher levels of NT-proBNP are independently associated with ischemic stroke, heart failure hospitalizations, and CV death in AF patients without oral anticoagulation treatment, irrespective of heart rhythm.
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- 2021
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4. Abstract 10162: NT-proBNP is Associated with Stroke, Heart Failure Hospitalizations, and Death in Patients with Atrial Fibrillation Without Oral Anticoagulation Regardless of Heart Rhythm
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Tomasdottir, Maria, primary, Hijazi, Ziad, additional, Lindback, Johan, additional, Benz, Alexander, additional, Connolly, Stuart J, additional, Eikelboom, John W, additional, Siegbahn, Agneta G, additional, Wallentin, Lars C, additional, and Oldgren, Jonas, additional
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- 2021
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5. Abstract 12070: Extracellular Vesicles, Derived Early After Myocardial Infarction, Inhibits Staurosporin Induced Cardiac Cell Death
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Khandagale, Avinash, primary, Lindahl, Bertil, additional, Siegbahn, Agneta G, additional, and Christersson, Christina, additional
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- 2021
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6. Early or synchronized gestures facilitate speech recall—a study based on motion capture data
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Jens Nirme, Agneta Gulz, Magnus Haake, and Marianne Gullberg
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gesture ,speech processing ,multimodal integration ,virtual animation ,timing ,Psychology ,BF1-990 - Abstract
IntroductionTemporal co-ordination between speech and gestures has been thoroughly studied in natural production. In most cases gesture strokes precede or coincide with the stressed syllable in words that they are semantically associated with.MethodsTo understand whether processing of speech and gestures is attuned to such temporal coordination, we investigated the effect of delaying, preposing or eliminating individual gestures on the memory for words in an experimental study in which 83 participants watched video sequences of naturalistic 3D-animated speakers generated based on motion capture data. A target word in the sequence appeared (a) with a gesture presented in its original position synchronized with speech, (b) temporally shifted 500 ms before or (c) after the original position, or (d) with the gesture eliminated. Participants were asked to retell the videos in a free recall task. The strength of recall was operationalized as the inclusion of the target word in the free recall.ResultsBoth eliminated and delayed gesture strokes resulted in reduced recall rates compared to synchronized strokes, whereas there was no difference between advanced (preposed) and synchronized strokes. An item-level analysis also showed that the greater the interval between the onsets of delayed strokes and stressed syllables in target words, the greater the negative effect was on recall.DiscussionThese results indicate that speech-gesture synchrony affects memory for speech, and that temporal patterns that are common in production lead to the best recall. Importantly, the study also showcases a procedure for using motion capture-based 3D-animated speakers to create an experimental paradigm for the study of speech-gesture comprehension.
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- 2024
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7. A tale about facts and opinions: The impact of a drama intervention on middle-school students´ information literacy
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Betty Tärning, Eva-Maria Ternblad, Agneta Gulz, and Magnus Haake
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Information technology ,T58.5-58.64 - Abstract
Today, huge amounts of data are produced, collected, and presented in all kinds of contexts. The ability to critically examine and evaluate information and arguments in relation to empirical evidence is often referred to as information literacy. It is of utmost importance that students are adequately scaffolded to develop this ability, to be able to become democratic citizens. The study presented combines learning science and drama to explore whether this approach can make 6 grade students more aware of certain aspects of information literacy, such as false balance, the burden of proof, and filter bubbles. Half of the students watched a play and participated in a pedagogical follow-up before answering a questionnaire. The other half answered the questionnaire before the intervention. Results show that students watching the play had grasped the core of the more tangible questions, writing more elaborated and relevant answers than students in the control group.
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- 2023
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8. Lessons from a preschool intervention study carried out during the Covid-19 pandemic
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Agneta Gulz and Magnus Haake
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Information technology ,T58.5-58.64 - Abstract
The article describes how a series of adaptions enabled us to carry out a controlled intervention study in 15 preschools, with 420 children and about 40 preschool teachers, during the Covid‑19 pandemic restrictions. The original overarching aim of the study was to develop and evaluate an early math intervention supporting children from low-SES environments to develop basic mathematical skills. The two main research questions addressed preschool children’s early math development using a digital play-&-learn game (anonymized), and the pedagogical impact of an integrated teacher resources package. Four guiding principles complemented the research questions: accumulation of new knowledge, collaboration & participatory design, experimental control & ecological validity, and real-world applicability. The focus of this article is on how data collections methods and analyses were adapted to handle the constraints induced by Covid‑19 without deviating from the original research questions and the four guiding principles. The adaptions clearly entailed methodological limitations. Yet the study demonstrates the possibility to conduct a remotely controlled effect study encompassing both ecological validity and real-world applicability
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- 2023
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9. Anomalous left coronary artery presenting with out-of-hospital cardiac arrest: a malignant outcome for a ‘benign’ variant
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Umar Syed Ali, Agneta Geldenhuys, Jacobus Otto, Rafeeq Samie, Girish Dwivedi, David Andrews, and Abdul Rahman Ihdayhid
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Acute coronary syndrome ,Cardiac surgery ,Computed tomography angiography ,Internal medicine ,RC31-1245 - Abstract
Abstract Background Anomalous left coronary arteries are rare congenital defects. These are often detected incidentally unless they have a malignant course whereby patients present with acute coronary syndromes. We describe a rare presentation of a benign variant of this pathology and a proposed diagnostic and management plan. Case presentation A 41-year-old female was admitted following an out-of-hospital cardiac arrest. Cardiac imaging demonstrated an anomalous left main coronary artery arising from a single right coronary ostium with a trans-septal course and associated ischaemic changes on functional testing. Given her clinical presentation, she underwent successful left coronary reimplantation surgery. Conclusions This case highlights that even supposedly ‘benign’ variants can have malignant outcomes and that functional testing can be useful in further risk-stratifying anomalous coronary anatomy. Surgical reimplantation is a feasible and effective treatment for achieving optimal long-term results
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- 2022
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10. Detection of EGFR mutations in tissue and plasma of NSCLC Patients
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Bica, M.G., primary, Russo Lacerna, C., additional, Guddo, F., additional, Spatafora, M., additional, Cannella, S., additional, Spinnato, F., additional, Agneta, G., additional, Rizzo, A., additional, Verderame, F., additional, and Santoro, A., additional
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- 2016
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11. When documentation becomes feedback: tensions in feedback activity in Learning Management Systems
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Agneta Grönlund, Joakim Samuelsson, and Johan Samuelsson
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feedback ,formative feedback ,social studies teaching ,upper-secondary school ,computer-aided teaching ,learning management system (lms) ,Education (General) ,L7-991 - Abstract
Teachers’ feedback via Learning Management Systems (LMSs) is studied within the subject of social studies at upper secondary school in Sweden. A qualitative study involved classroom observations within LMSs, gathering teachers’ feedback on pupils’ submitted assignments, and semi-structured interviews with six teachers. With the support of activity theory, the interest of the study was directed towards the tensions that arise in an activity system consisting of teachers’ feedback actions in a digital assessment context. The results reveal tensions in the relationship between grading documentation in the LMS and the subject’s traditions in the form of discussions, for example. Tensions were distinguished in the interaction between a school policy of using a feedback matrix and teachers’ formative ideals. Tensions were also distinguished between teachers’ need to legitimise grades and give feedback according to formative ideals. Finally, a tension was distinguished between the time available for providing feedback and teachers’ formative ideals for giving feedback.
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- 2021
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12. Early Math in a Preschool Context: Spontaneous Extension of the Digital into the Physical
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Agneta Gulz, Susanne Kjällander, Sofia Frankenberg, and Magnus Haake
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Information technology ,T58.5-58.64 - Abstract
The paper presents a systematic examination of data from two early math interventions, involving 188 children aged 3,5-6,5 and their teachers. The aim is to cast light on how a digital early math game can be spontaneously extended into the physical environment by children and by teachers. Questions were: i) how the math content was extended to the physical room, ii) which elements of the game and the interventions inspired and provided affordances for the extensions iii) implications for children’s learning of early math. The analyses revealed a great variety of ways in which children and teachers – acting on their own or together – brought the game out to the physical room. Among the underlying factors for this were everyone’s experiences with the game, familiar narratives, and simple game design in terms of rules and visual features. Finally, positive influences on early math learning from the extensions were identified.
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- 2020
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13. How we do it Emergency Department Thoracotomy for Penetrating Pulmonary Trauma.
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Elias Degiannis, Agneta Geldenhuis, Konstantinos Degiannis, Jason Degiannis, Matthias Maak, and Dietrich Doll
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pulmonary trauma, Emergency Department Thoracotomy ,Penetrating trauma ,ERT ,Surgery ,RD1-811 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract The manuscript specifically concentrates on patients with penetrating thoracic trauma, who having undergone Emergency Department Thoracotomy (EDT) have been diagnosed with injury to the lung. Its purpose is to describe a practical / heuristic approach, enabling the inexperienced in thoracic surgery doctor, to perform a successful EDT and if need arises, a definitive operation in the absence of a Cardiothoracic or appropriately trained Trauma Surgeon.
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- 2022
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14. A26 - Detection of EGFR mutations in tissue and plasma of NSCLC Patients
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Bica, M.G., Russo Lacerna, C., Guddo, F., Spatafora, M., Cannella, S., Spinnato, F., Agneta, G., Rizzo, A., Verderame, F., and Santoro, A.
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- 2016
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15. Implementing a Practical Global Health Curriculum: The Benefits and Challenges of Patient-Based Learning in the Community
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Seema Biswas, Nathan T. Douthit, Keren Mazuz, Zach Morrison, Devin Patchell, Michael Ochion, Leslie Eidelman, Agneta Golan, Michael Alkan, Tzvi Dwolatzky, John Norcini, Igor Waksman, Evgeny Solomonov, and A. Mark Clarfield
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global health ,medical education in the community ,patient-centered curriculum ,social determinants of health ,global health competencies ,Public aspects of medicine ,RA1-1270 - Abstract
Background: A growing number of medical schools across the world have incorporated global health (GH) into their curricula. While several schools focus GH education on lecture-based courses, our premise is that global health education should embody a holistic approach to patient care and medical education in local communities. Medical students may learn global health by focusing on real patients, their families and communities as part of a practical curriculum.Aims and Objectives: A unique GH curriculum was devised to compare student learning outcomes on a practical vs. lecture-based course. The premise was that learning from patients would result in a greater breadth of coverage of the global health syllabus as compared to that from a lecture-based course.Methods: A teaching and learning program was developed over 3 years to provide medical students interaction with real patients in the community on a first-preclinical-year Introduction to Global Health and Medical Anthropology course. Learning outcomes on the practical vs. lecture-based course were compared using thematic analysis of the written assignments of both courses: global health case reports and literature reviews, respectively. All members of three cohorts of students undertaking the course in successive academic years were compared (Group A: literature review; Groups B and C: case reports; n = 87).Results: Case reports provided evidence of a greater breadth of learning outcomes when compared to the literature review (p < 0.001). The writing of the case report was enhanced by completion of a field journal and family health needs assessment tool (p < 0.001). Students demonstrated a closeness to their patients that added depth, understanding and motivation to assist patients in health activities and advocate for their needs.Discussion: Placements with patients in the community provided students with a rich learning environment and facilitated the formation of relationships with patients to better understand the social determinants of health and advocate for improvements in their living and working conditions and access to healthcare.Conclusions: Global health may be better learned experientially by following patients rather than from frontal lectures. Patient-based learning inspires a commitment to the individual and facilitates medical schools in meeting their obligations to the communities they serve.
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- 2020
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16. Young Children’s Experience and Preference of Feedback – Sense and Sensibility
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Betty Tärning, Björn Sjödén, Agneta Gulz, and Magnus Haake
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Information technology ,T58.5-58.64 - Abstract
This study explored the effects of adding visual continuous feedback in the form of feedback bars to a teachable-agent based learning game in mathematics. 45 8-12-years-old from three Swedish school classes used the game during four math lessons. The focus was on how feedback to the students regarding their teachable agents learning progression – and different detailedness of such feedback – affects how the students (in a teacher role) experience the learning game. The results suggest that students were positive towards receiving immediate and continuous feedback, but their preferences with respect to the detailedness of the feedback differed according to their age. We found a divergence as to the preferred number of bars, where the 3rdand 5thgraders preferred 1 or 3 bars but where the 2ndgraders preferred the more detailed version (6 bars) despite their lack of understanding of what the different bars represented.
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- 2018
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17. Kinematic analysis of the basement-cover contact of the western margin of the Grong-Olden Culmination, central Norwegian Caledonides
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Månsson, Agneta G. and Månsson, Agneta G.
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In orogenic belts, the relations between basement and cover rocks are important because of the information they give about the nature and evolution of the belt. In the Scandinavian Caledonides, basement-cover contacts can be found in windows where Precambrian basement has been exposed in antiformal structures, due to the deep erosion level of the mountain chain. The Grong-Olden Culmination (NE of Trondheim, central Norway) is one such window, composed of two antiforms: the E-W trending Grong Antiform and the N-S trending Olden Antiform. This microstructural study is focused on the kinematics in the rocks adjacent to a basement-cover contact. Kinematic indicators are structures which indicate the sense of shear in deformed rocks. The types used in this study are augen with asymmetric tails and pressure shadows, rotated garnets, C-S fabric, mica fishes and shear bands; emphasis is laid on augen and C-S fabrics. The basement rocks are in general light grey to pink mylonitic gneisses with a pervasive foliation and a strong feldspar+quartz mineral streaking lineation. The thin cover unit consists of a dark garnet bearing quartz-mica schist with a phyllonitic texture, called phyllonites. The lineation is defined by stretched quartz and mica. The results suggest an over all W-NW direction of movement, with indications of an earlier SE directed movement. As driving mechanism of the W-NW shearing, normal faulting superimposed on eastward thrusting is suggested.
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- 1990
18. Does the use of immunohistochemistry to identify micrometastases provide useful information in the staging of node-negative non-small cell lung carcinomas?
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Nicholson, A.G, primary, Graham, A.N.J, additional, Pezzella, F, additional, Agneta, G, additional, Goldstraw, P, additional, and Pastorino, U, additional
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- 1997
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19. 671 Does the use of immunohistochemistry to identify occult metastases provide useful information in the staging of node-negative non-small cell carcinomas?
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Nicholson, A.G., primary, Graham, A.N.J., additional, Pezzella, F., additional, Agneta, G., additional, Pastorino, U., additional, and Goldstraw, P., additional
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- 1997
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20. Preventive strategies and factors associated with surgically treated necrotising enterocolitis in extremely preterm infants: an international unit survey linked with retrospective cohort data analysis
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Dirk Bassler, Kei Lui, Michael Dunn, Victor Samuel Rajadurai, Mikael Norman, Alejandro Avila-Alvarez, Marc Beltempo, Mark Adams, Barbara Bajuk, Malcolm Battin, Jean-François Tolsa, Ruben Alvaro, Chuks Nwaesei, Martine Claveau, Shoo K Lee, Prakesh S Shah, Zenon Cieslak, Rebecca Sherlock, Wendy Yee, Carlos Fajardo, Zarin Kalapesi, Koravangattu Sankaran, Mary Seshia, Amit Mukerji, Orlando Da Silva, Kyong-Soon Lee, Brigitte Lemyre, Kimberly Dow, Ermelinda Pelausa, Keith Barrington, Christine Drolet, Bruno Piedboeuf, Valerie Bertelle, Edith Masse, Roderick Canning, Hala Makary, Cecil Ojah, Luis Monterrosa, Jehier Afifi, Andrzej Kajetanowicz, lex Doyle, Roland Broadbent, Ross Haslam, Peter Marshall, Peter Schmidt, Paul Craven, Koert De Waal, Karen Simmer, Andy Gill, Jacqueline Stack, Dan Casalaz, Jim Holberton, Lucy Cooke, Lyn Downe, Michael Stewart, Andrew Berry, Rod Hunt, Charles Kilburn, Tony De Paoli, Mary Paradisis, Ingrid Rieger, Pieter Koorts, Carl Kuschel, Andrew Numa, Hazel Carlisle, Nadia Badawi, Guan Koh, Melissa Luig, Chad Andersen, Adrienne Lynn, Brian Darlow, Lindsay Mildenhall, Mariam Buksh, David Bourchier, Vaughan Richardson, Georgina Chambers, Robert Halliday, Thomas Riedel, Anne Synnes, Amir Kugelman, W Coroleu, Liisa Lehtonen, Brian A Darlow, Brian Reichman, Stellan Hakansson, Kjell K Helenius, Laura San Feliciano, Maximo Vento, Marco Moroni, Junmin Yang, Adam Buckmaster, Charles Barfield, Vijay Shingde, Shelley Reid, David Cartwright, Steven Resnick, Jutta van den Boom, Lee Carpenter, Adele Harrison, Khalid Aziz, Akhil Deshpandey, Sture Andersson, Outi Tammela, Ulla Sankilampi, Timo Saarela, Eli Heymann, Shmuel Zangen, Tatyana Smolkin, Francis Mimouni, David Bader, Avi Rothschild, Zipora Strauss, Clari Felszer, Hussam Omari, Smadar Even Tov-Friedman, Benjamin Bar-Oz, Michael Feldman, Nizar Saad, Orna Flidel-Rimon, Meir Weisbrod, Daniel Lubin, Ita Litmanovitz, Eric Shinwell, Gil Klinger, Yousif Nijim, Alona Bin-Nun, Agneta Golan, Dror Mandel, Vered Fleisher-Sheffer, David Kohelet, Lev Bakhrakh, José Luis Fernandez-Trisac, Ma Luz Couce Pico, María José Fernández Seara, Andrés Martínez Gutiérrez, Carolina Vizcaíno, Miriam Salvador Iglesias, Honorio Sánchez Zaplana, Belén Fernández Colomer, José Enrique García López, M Rafael García Mozo, Teresa González Martínez, Mª Dolores Muro Sebastián, Marta Balart Carbonell, Joan Badia Barnusell, Mònica Domingo Puiggròs, Corporacio Parc Taulí, Josep Figueras Aloy, Francesc Botet Mussons, Israel Anquela Sanz, Gemma Ginovart Galiana, Martin Iriondo, Laura Castells Vilella, Roser Porta, Xavier Demestre, Silvia Martínez Nadal, Cristina de Frutos Martínez, María Jesús López Cuesta, Dolores Esquivel Mora, Joaquín Ortiz Tardío, Isabel Benavente, Almudena Alonso, Ramón Aguilera Olmos, Miguel A García Cabezas, Mª Dolores Martínez Jiménez, Mª Pilar Jaraba Caballero, Mª Dolores Ordoñez Díaz, Alberto Trujillo Fagundo, Lluis Mayol Canals, Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, María Fernanda Moreno Galdo, José Antonio Hurtado Suazo, Eduardo Narbona López, José Uberos Fernández, Miguel A Cortajarena Altuna, Oihana Muga, David Mora Navarro, María Teresa Domínguez, Mª Yolanda Ruiz del Prado, Inés Esteban Díez, María Teresa Palau Benavides, Santiago Lapeña, Teresa Prada, Eduard Soler Mir, Araceli Corredera Sánchez, Enrique Criado Vega, Náyade del Prado, Cristina Fernández, Lucía Cabanillas Vilaplana, Irene Cuadrado Pérez, Luisa López Gómez, Laura Domingo Comeche, Isabel Llana Martín, Carmen González Armengod, Carmen Muñoz Labián, Mª José Santos Muñoz, Dorotea Blanco Bravo, Vicente Pérez, Mª Dolores Elorza Fernández, Celia Díaz González, Susana Ares Segura, Manuela López Azorín, Ana Belén Jimenez, Tomás Sánchez-Tamayo, Elías Tapia Moreno, María González, Beatriz Vacas del Arco, Josefina Márquez Fernández, Laura Acosta Gordillo, Mercedes Granero Asensio, Carmen Macías Díaz, Mar Albújar, Pedro Fuster Jorge, Sabina Romero, Ana Belén Escobar Izquierdo, Javier Estañ Capell, Mª Isabel Izquierdo Macián, Mª Mar Montejo Vicente, Raquel Izquierdo Caballero, Mª Mercedes Martínez, Aintzane Euba, Amaya Rodríguez Serna, Juan María López de Heredia Goya, Alberto Pérez Legorburu, Ana Gutiérrez Amorós, Víctor Manuel Marugán Isabel, Natalio Hernández González, Segundo Rite Gracia, Mª Purificación Ventura Faci, Mª Pilar Samper Villagrasa, Jiri Kofron, Katarina Strand Brodd, Andreas Odlind, Lars Alberg, Sofia Arwehed, Ola Hafström, Anna Kasemo, Karin Nederman, Lars Åhman, Fredrik Ingemarsson, Henrik Petersson, Pernilla Thurn, Eva Albinsson, Bo Selander, Thomas Abrahamsson, Ingela Heimdahl, Kristbjorg Sveinsdottir, Erik Wejryd, Anna Hedlund, Maria Katarina Söderberg, Boubou Hallberg, Thomas Brune, Jens Bäckström, Johan Robinson, Aijaz Farooqi, Erik Normann, Magnus Fredriksson, Anders Palm, Urban Rosenqvist, Bengt Walde, Cecilia Hagman, Andreas Ohlin, Rein Florell, Agneta Smedsaas-Löfvenberg, Philipp Meyer, Claudia Anderegg, Sven Schulzke, Mathias Nelle, Bendicht Wagner, Grégoire Kaczala, Riccardo E Pfister, Matthias Roth, Martin Stocker, Bernhard Laubscher, Andreas Malzacher, John P Micallef, Lukas Hegi, Romaine Arlettaz, Carlo Dani, Patrizio Fiorini, Paolo Ghirri, Barbara Tomasini, and Franca Rusconi
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Medicine - Abstract
Objectives To compare necrotising enterocolitis (NEC) prevention practices and NEC associated factors between units from eight countries of the International Network for Evaluation of Outcomes of Neonates, and to assess their association with surgical NEC rates.Design Prospective unit-level survey combined with retrospective cohort study.Setting Neonatal intensive care units in Australia/New Zealand, Canada, Finland, Israel, Spain, Sweden, Switzerland and Tuscany (Italy).Patients Extremely preterm infants born between 240 to 286 weeks’ gestation, with birth weights
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- 2019
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21. Quality of life in Swedish children with congenital ichthyosis
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Agneta Gånemo
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Ichthyosis, Netherton`s syndrome, Harlequin ichthyosis, Children’s Dermatology Life Quality Index, Skin disease ,Dermatology ,RL1-803 - Abstract
Congenital ichthyosis encompasses a large group of keratinizing disorders with widespread scaling and a variable degree of erythema. Little is known about the quality of life in children with congenital ichthyosis and the impact of the disease on their family. Fifteen children aged 5-16 years with lamellar ichthyosis, Netherton’s syndrome, epidermolytic hyperkeratosis or Harlequin ichthyosis, were investigated concerning the effect of their ichthyosis on their quality of life. This was measured with the established Children’s Dermatology Life Quality Index (CDLQI), and the Dermatitis Family Impact questionnaire (DFI) modified by substituting the word ichthyosis for eczema. The questionnaires covered the preceding seven days and each had a maximum score of 30: the higher the score, the greater the Quality of Life impairment. The median score was 9.0 (range 2-19) for the CDLQI and 9.0 (range 3-21) for DFI. There was a significant correlation between the DFI and the CDLQI scores. The item in the CDLQI questionnaire that showed the highest score was “itchy, scratchy, sore or painful skin” and the most highly scored item in the DFI questionnaire was effect on “housework, e.g. washing, cleaning”; both items related to the children’s symptoms. The results of the study clearly establish that congenital ichthyosis impairs the quality of life of the affected children and their families.
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- 2010
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22. Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer
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Alberto Firenze, Livio Blasi, Francesco Verderame, Alba La Sala, I. Fazio, Sergio Rizzo, Hector Soto-parra, Gianluca Mortillaro, Roberto Marchese, Maurizio Chiarenza, Giuseppe Agneta, M. Spada, Dario Piazza, Enrico Potenza, Helga Lipari, M. R. Valerio, Concetta Sergi, Sergio Baldari, Amato C, Alfio Di Grazia, F. Ferraù, Alessandro Bertani, Elena Roz, Vittorio Gebbia, Gianfranco Mancuso, A. Guarini, Gebbia V., Guarini A., Piazza D., Bertani A., Spada M., Verderame F., Sergi C., Potenza E., Fazio I., Blasi L., La Sala A., Mortillaro G., Roz E., Marchese R., Chiarenza M., Soto-Parra H., Valerio M.R., Agneta G., Amato C., Lipari H., Baldari S., Ferrau F., Di Grazia A., Mancuso G., Rizzo S., and Firenze A.
- Subjects
Pulmonary and Respiratory Medicine ,Multidisciplinary tumor boards ,Teamwork ,Process management ,Referral ,Process (engineering) ,Computer science ,media_common.quotation_subject ,Review ,Virtualization ,computer.software_genre ,medicine.disease ,Oncology networks ,Clinical trial ,Multidisciplinary approach ,Respiratory Care ,medicine ,Narrative review ,Lung cancer ,computer ,media_common - Abstract
To date, the virtual multidisciplinary tumor boards (vMTBs) are increasingly used to achieve high-quality treatment recommendations across health-care regions, which expands and develops the local MTB team to a regional or national expert network. This review describes the process of lung cancer-specific MTBs and the transition process from face-to-face tumor boards to virtual ones. The review also focuses on the project organization's description, advantages, and disadvantages. Semi-structured interviews identified five major themes for MTBs: current practice, attitudes, enablers, barriers, and benefits for the MTB. MTB teams exhibited positive responses to modeled data feedback. Virtualization reduces time spent for travel, allowing easier and timely patient discussions. This process requires a secure web platform to assure the respect of patients’ privacy and presents the same unanswered problems. The implementation of vMTB also permits the implementation of networks especially in areas with geographical barriers facilitating interaction between large referral cancer centers and tertiary or community hospitals as well as easier access to clinical trial opportunities. Studies aimed to improve preparations, structure, and conduct of MTBs, research methods to monitor their performance, teamwork, and outcomes are also outlined in this article. Analysis of literature shows that MTB participants discuss 5–8 cases per meeting and that the use of a vMTB for lung cancer and in particular stage III NSCLC and complex stage IV cases is widely accepted by most health professionals.Despite still-existing gaps, overall vMTB represents a unique opportunity to optimize patient management in apatient-centeredapproach.
- Published
- 2021
- Full Text
- View/download PDF
23. Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer.
- Author
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Gebbia V, Guarini A, Piazza D, Bertani A, Spada M, Verderame F, Sergi C, Potenza E, Fazio I, Blasi L, La Sala A, Mortillaro G, Roz E, Marchese R, Chiarenza M, Soto-Parra H, Valerio MR, Agneta G, Amato C, Lipari H, Baldari S, Ferraù F, Di Grazia A, Mancuso G, Rizzo S, and Firenze A
- Abstract
To date, the virtual multidisciplinary tumor boards (vMTBs) are increasingly used to achieve high-quality treatment recommendations across health-care regions, which expands and develops the local MTB team to a regional or national expert network. This review describes the process of lung cancer-specific MTBs and the transition process from face-to-face tumor boards to virtual ones. The review also focuses on the project organization's description, advantages, and disadvantages. Semi-structured interviews identified five major themes for MTBs: current practice, attitudes, enablers, barriers, and benefits for the MTB. MTB teams exhibited positive responses to modeled data feedback. Virtualization reduces time spent for travel, allowing easier and timely patient discussions. This process requires a secure web platform to assure the respect of patients' privacy and presents the same unanswered problems. The implementation of vMTB also permits the implementation of networks especially in areas with geographical barriers facilitating interaction between large referral cancer centers and tertiary or community hospitals as well as easier access to clinical trial opportunities. Studies aimed to improve preparations, structure, and conduct of MTBs, research methods to monitor their performance, teamwork, and outcomes are also outlined in this article. Analysis of literature shows that MTB participants discuss 5-8 cases per meeting and that the use of a vMTB for lung cancer and in particular stage III NSCLC and complex stage IV cases is widely accepted by most health professionals. Despite still-existing gaps, overall vMTB represents a unique opportunity to optimize patient management in a patient-centered approach., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
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