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Objective: To determine the prevalence of potential drug–drug interactions involving psychotropics prescribed by dentists, and dispensed by the public healthcare system, as well as to describe the severity and level of evidence of those interactions in the state of Minas Gerais, Brazil. Materials and Methods: We conducted data analysis from pharmaceutical claims in which dental patients received systemic psychotropics in 2017. Data from the Pharmaceutical Management System provided the drug dispensing history of the patients, allowing the identification of those on concomitant medication use. The outcome was the occurrence of potential drug–drug interactions, which were detected according to IBM Micromedex®. Independent variables were the patient's sex, age, and the number of drugs used. Descriptive statistics was performed using SPSS v. 26. Results: Overall, 1480 individuals were prescribed psychotropic drugs. The prevalence of potential drug–drug interactions was 24.8% (n = 366). The total of 648 interactions was observed and, most of which were of major severity (n = 438, 67.6%). Most interactions occurred in female individuals (n = 235; 64.2%), with 46.0 (±17.3) years‐old, concurrently taking 3.7 (±1.9) drugs. Conclusion: A substantial proportion of dental patients presented potential drug–drug interactions, mostly of major severity, which might be life‐threatening. [ABSTRACT FROM AUTHOR]

In this work, the results obtained in different tests performed on a Stirling cryocooler are shows, as well as a comparative analysis of these results with different load pressures. The prototype is a single-acting Stirling engine with a piston and displacer, which is used to liquefy air with helium as the working fluid; this is an integral Stirling (β-type). A three-phase asynchronous electric motor drives the Stirling engine and cooling, in the hot focus, is performed with a pressurized water circuit. In the cold focus are reached very low temperatures, around 75 K (-198 °C). The study has been developed at different load pressures of the working fluid and it shows a comparative analysis about the most important work parameters evolution. The parameters studied are the following: cooling water inlet and outlet temperatures, cold and hot focus temperatures, voltage and intensity consumed by the electric motor that drives the Stirling engine and quantity of liquid air obtained. The results show that it is very likely to use this configuration in industrial processes when they need cold and heat simultaneously.

Introduction: Racial/ethnic disparities in living donor kidney transplantation (LDKT) are a persistent challenge. Although nearly all directed donations are from members of patients' social networks, little is known about which social network members take steps toward living kidney donation, which do not, and what mechanisms contribute to racial/ethnic LDKT disparities. Methods: We describe the design and rationale of the Friends and Family of Kidney Transplant Patients Study, a factorial experimental fielding two interventions designed to promote LKD discussions. Participants are kidney transplant candidates at two centers who are interviewed and delivered an intervention by trained center research coordinators. The search intervention advises patients on which social network members are most likely to be LKD contraindication‐free; the script intervention advises patients on how to initiate effective LKD discussions. Participants are randomized into four conditions: no intervention, search only, script only, or both search and script. Patients also complete a survey and optionally provide social network member contact information so they can be surveyed directly. This study will seek to enroll 200 transplant candidates. The primary outcome is LDKT receipt. Secondary outcomes include live donor screening and medical evaluations and outcomes. Tertiary outcomes include LDKT self‐efficacy, concerns, knowledge, and willingness, measured before and after the interventions. Conclusion: This study will assess the effectiveness of two interventions to promote LKD and ameliorate Black‐White disparities. It will also collect unprecedented information on transplant candidates' social network members, enabling future work to address network member structural barriers to LKD. [ABSTRACT FROM AUTHOR]