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2. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Author
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Huckins, L. M., Hatzikotoulas, K., Curtis, C., Esko, T., Espeseth, T., Estivill, X., Favaro, A., Fernández-Aranda, F., Fichter, M. M., Finan, C., Fischer, K., Floyd, J. A. B., Foretova, L., Rhodes, D., Forzan, M., Franklin, C. S., Gallinger, S., Gambaro, G., Gaspar, H. A., Giegling, I., Gonidakis, F., Gorwood, P., Gratacos, M., Guillaume, S., Moens, J., Guo, Y., Hakonarson, H., Halmi, K. A., Hauser, J., Hebebrand, J., Helder, S., Herms, S., Herpertz-Dahlmann, B., Herzog, W., Kalsi, G., Hilliard, C. E., Hinney, A., Hübel, C., Hudson, J. I., Huemer, J., Inoko, H., Janout, V., Jiménez-Murcia, S., Johnson, C., Dempster, D., Julià, A., Juréus, A., Kaminska, D., Kaplan, A. S., Kaprio, J., Karhunen, L., Karwautz, A., Kas, M. J. H., Kaye, W., Leung, R., Kennedy, J. L., Keski-Rahkonen, A., Kiezebrink, K., Klareskog, L., Klump, K. L., Knudsen, G. P. S., Koeleman, B. P. C., Koubek, D., La Via, M. C., Landén, M., Keohane, A., Le Hellard, S., Levitan, R. D., Li, D., Lichtenstein, P., Lilenfeld, L., Lissowska, J., Lundervold, A., Magistretti, P., Maj, M., Mannik, K., Burghardt, R., Marsal, S., Martin, N., Mattingsdal, M., McDevitt, S., McGuffin, P., Merl, E., Metspalu, A., Meulenbelt, I., Micali, N., Mitchell, J., Ehrlich, S., Mitchell, K., Monteleone, P., Monteleone, A. M., Mortensen, P., Munn-Chernoff, M. A., Navratilova, M., Nilsson, I., Norring, C., Ntalla, I., Ophoff, R. A., O'Toole, J. K., Palotie, A., Pante, J., Papezova, H., Pinto, D., Rabionet, R., Raevuori, A., Rajewski, A., Ramoz, N., Rayner, N. W., Southam, L., Reichborn-Kjennerud, T., Ripatti, S., Roberts, M., Rotondo, A., Rujescu, D., Rybakowski, F., Santonastaso, P., Scherag, A., Scherer, S. W., Schmidt, U., Ludolph, A., Schork, N. J., Schosser, A., Slachtova, L., Sladek, R., Slagboom, P. E., Slof-Op 't Landt, M. C. T., Slopien, A., Soranzo, N., Steen, V. M., Walton, E., Strengman, E., Strober, M., Sullivan, P. F., Szatkiewicz, J. P., Szeszenia-Dabrowska, N., Tachmazidou, I., Tenconi, E., Thornton, L. M., Tortorella, A., Tozzi, F., Deloukas, P., Treasure, J., Tsitsika, A., Tziouvas, K., van Elburg, A. A., van Furth, E. F., Wagner, G., Watson, H., Wichmann, H-E, Widen, E., Hofman, A., Woodside, D. B., Yanovski, J., Yao, S., Yilmaz, Z., Zeggini, E., Zerwas, S., Zipfel, S., Palta, P., van Rooij, F. J. A., Stirrups, K., Adan, R., Boni, C., Cone, R., Dedoussis, G., van Furth, E., Hudson, J., Kas, M., Keski-Rahonen, A., Steinberg, J., Knudsen, G-P, Raevuori, A. H., Aguilera-McKay, F., van Elburg, A., Consortium, Eating Disorder Working Group of the Psychiatric Genomics, Collier, D. A., Breen, G., Bulik, C. M., Adan, R. A. H., Alfredsson, L., Ando, T., Andreassen, O. A., Aschauer, H., Baker, J. H., Barrett, J. C., Bencko, V., Bergen, A. W., Berrettini, W. H., Birgegard, A., Boraska Perica, V., Brandt, H., Carlberg, L., Cassina, M., Cichon, S., Clementi, M., Cohen-Woods, S., Coleman, J., Cone, R. D., Gunasinghe, C., Courtet, P., Crawford, S., Crow, S., Crowley, J., Danner, U. N., Davis, O. S. P., de Zwaan, M., Degortes, D., DeSocio, J. E., Romero, A., Dick, D. M., Dikeos, D., Dina, C., Ding, B., Dmitrzak-Weglarz, M., Docampo, E., Duncan, L., Egberts, K., Escaramís, G., Inconnu, Institut Pasteur de Côte d'Ivoire, Réseau International des Instituts Pasteur (RIIP), Laboratoire de bactériologie-virologie, CHU de Yopougon, Department of Nutrition Science & Dietetics, Harokopio University, Analyse Phenotypique, Developpementale et Genetique des Comportements Addictifs, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, Clinicum, University of Helsinki, Department of Public Health, Anna Keski-Rahkonen / Principal Investigator, HUS Children and Adolescents, Genomics of Neurological and Neuropsychiatric Disorders, Genetic Epidemiology, Eating Disorder Working Group of the Psychiatric Genomics Consortium, Epidemiology, Kas lab, Huckins, L. M., Hatzikotoulas, K., Southam, L., Thornton, L. M., Steinberg, J., Aguilera-Mckay, F., Treasure, J., Schmidt, U., Gunasinghe, C., Romero, A., Curtis, C., Rhodes, D., Moens, J., Kalsi, G., Dempster, D., Leung, R., Keohane, A., Burghardt, R., Ehrlich, S., Hebebrand, J., Hinney, A., Ludolph, A., Walton, E., Deloukas, P., Hofman, A., Palotie, A., Palta, P., van Rooij, F. J. A., Stirrups, K., Adan, R., Boni, C., Cone, R., Dedoussis, G., van Furth, E., Gonidakis, F., Gorwood, P., Hudson, J., Kaprio, J., Kas, M., Keski-Rahonen, A., Kiezebrink, K., Knudsen, G. -P., Slof-Op 'T Landt, M. C. T., Maj, M., Monteleone, A. M., Monteleone, P., Raevuori, A. H., Reichborn-Kjennerud, T., Tozzi, F., Tsitsika, A., Elburg, A., Collier, D. A., Sullivan, P. F., Breen, G., Bulik, C. M., Zeggini, E., Adan, R. A. H., Alfredsson, L., Ando, T., Andreassen, O. A., Aschauer, H., Baker, J. H., Barrett, J. C., Bencko, V., Bergen, A. W., Berrettini, W. H., Birgegard, A., Perica, V. B., Brandt, H., Carlberg, L., Cassina, M., Cichon, S., Clementi, M., Cohen-Woods, S., Coleman, J., Cone, R. D., Courtet, P., Crawford, S., Crow, S., Crowley, J., Danner, U. N., Davis, O. S. P., Zwaan, M., Degortes, D., Desocio, J. E., Dick, D. M., Dikeos, D., Dina, C., Ding, B., Dmitrzak-Weglarz, M., Docampo, E., Duncan, L., Egberts, K., Escaramis, G., Esko, T., Espeseth, T., Estivill, X., Favaro, A., Fernandez-Aranda, F., Fichter, M. M., Finan, C., Fischer, K., Floyd, J. A. B., Foretova, L., Forzan, M., Franklin, C. S., Gallinger, S., Gambaro, G., Gaspar, H. A., Giegling, I., Gratacos, M., Guillaume, S., Guo, Y., Hakonarson, H., Halmi, K. A., Hauser, J., Helder, S., Herms, S., Herpertz-Dahlmann, B., Herzog, W., Hilliard, C. E., Hubel, C., Hudson, J. I., Huemer, J., Inoko, H., Janout, V., Jimenez-Murcia, S., Johnson, C., Julia, A., Jureus, A., Kaminska, D., Kaplan, A. S., Karhunen, L., Karwautz, A., Kas, M. J. H., Kaye, W., Kennedy, J. L., Keski-Rahkonen, A., Klareskog, L., Klump, K. L., Knudsen, G. P. S., Koeleman, B. P. C., Koubek, D., Via, M. C. L., Landen, M., Hellard, S. L., Levitan, R. D., Li, D., Lichtenstein, P., Lilenfeld, L., Lissowska, J., Lundervold, A., Magistretti, P., Mannik, K., Marsal, S., Martin, N., Mattingsdal, M., Mcdevitt, S., Mcguffin, P., Merl, E., Metspalu, A., Meulenbelt, I., Micali, N., Mitchell, J., Mitchell, K., Mortensen, P., Munn-Chernoff, M. A., Navratilova, M., Nilsson, I., Norring, C., Ntalla, I., Ophoff, R. A., O'Toole, J. K., Pantel, J., Papezova, H., Pinto, D., Rabionet, R., Raevuori, A., Rajewski, A., Ramoz, N., Rayner, N. W., Ripatti, S., Roberts, M., Rotondo, A., Rujescu, D., Rybakowski, F., Santonastaso, P., Scherag, A., Scherer, S. W., Schork, N. J., Schosser, A., Slachtova, L., Sladek, R., Slagboom, P. E., Slopien, A., Soranzo, N., Steen, V. M., Strengman, E., Strober, M., Szatkiewicz, J. P., Szeszenia-Dabrowska, N., Tachmazidou, I., Tenconi, E., Tortorella, A., Tziouvas, K., Elburg, A. A., Furth, E. F., Wagner, G., Watson, H., Wichmann, H. -E., Widen, E., Woodside, D. B., Yanovski, J., Yao, S., Yilmaz, Z., Zerwas, S., and Zipfel, S.
- Subjects
Male ,0301 basic medicine ,Anorexia Nervosa ,[SDV]Life Sciences [q-bio] ,Intron ,Medizin ,Genome-wide association study ,Genome ,3124 Neurology and psychiatry ,Intergenic region ,Molecular Biology ,Psychiatry and Mental Health ,Cellular and Molecular Neuroscience ,Exome ,HYPOGONADOTROPIC HYPOGONADISM ,GENE-EXPRESSION ,Genetics ,Bulimia nervosa ,ASSOCIATION ,GPI-Linked Protein ,3. Good health ,CONTROLLED-TRIALS ,Psychiatry and Mental health ,Eating disorders ,Phenotype ,CONTROLLED FAMILY ,Female ,Original Article ,Human ,Genotype ,In silico ,European Continental Ancestry Group ,Locus (genetics) ,Biology ,GPI-Linked Proteins ,Polymorphism, Single Nucleotide ,White People ,03 medical and health sciences ,BULIMIA-NERVOSA ,medicine ,Journal Article ,Humans ,Family ,Genetic Predisposition to Disease ,ddc:610 ,Genetic association ,AUTISM SPECTRUM DISORDER ,3112 Neurosciences ,Genetic Variation ,Correction ,EATING-DISORDERS ,ARACHIDONIC-ACID ,medicine.disease ,Introns ,030104 developmental biology ,Cell Adhesion Molecule ,RISK-FACTORS ,3111 Biomedicine ,Cell Adhesion Molecules ,Genome-Wide Association Study - Abstract
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
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- 2017
- Full Text
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3. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Author
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Huckins, Laura M., Hatzikotoulas, Konstantinos, Southam, L., Thornton, Laura M., Steinberg, J.S., Aguilera-McKay, F, Treasure, J., Schmidt, U., Gunasinghe, C, Romero, Atocha, Curtis, Charles, Rhodes, Davina H., Bernelot Moens, Hein J, Kalsi, Gursharan, Dempster, D, Leung, R, Keohane, A, Burghardt, Roland, Ehrlich, S., Hebebrand, J., Hinney, A., Ludolph, A., Walton, Esther, Deloukas, P., Hofman, A., Palotie, A., Palta, P., Van Rooij, Frank J A, Stirrups, Kathleen, Adan, R, Boni, Claudette, Cone, Roger, Dedoussis, George, Furth, E.E., Gonidakis, Fragiskos, Gorwood, P., Hudson, Thomas J., Kaprio, Jaakko, Kas, M, Keski-Rahonen, A, Kiezebrink, K., Knudsen, Gun Peggy S., Slof-Op 't Landt, M C T, Maj, Mario, Monteleone, Alessio Maria, Monteleone, Palmiero, Raevuori, A H, Reichborn-Kjennerud, Ted, Tozzi, F., Tsitsika, Artemis, and Eating Disorder Working Group of the Psychiatric Genomics Consortium
- Abstract
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10-6), and rs7700147, an intergenic variant (P=2.93 × 10-5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.Molecular Psychiatry advance online publication, 25 July 2017; doi:10.1038/mp.2017.88.
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- 2018
4. Correction to: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa (Molecular Psychiatry, (2018), 23, 5, (1169-1180), 10.1038/mp.2017.88)
- Author
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Huckins, L.M. Hatzikotoulas, K. Southam, L. Thornton, L.M. Steinberg, J. Aguilera-McKay, F. Treasure, J. Schmidt, U. Gunasinghe, C. Romero, A. Curtis, C. Rhodes, D. Moens, J. Kalsi, G. Dempster, D. Leung, R. Keohane, A. Burghardt, R. Ehrlich, S. Hebebrand, J. Hinney, A. Ludolph, A. Walton, E. Deloukas, P. Hofman, A. Palotie, A. Palta, P. van Rooij, F.J.A. Stirrups, K. Adan, R. Boni, C. Cone, R. Dedoussis, G. van Furth, E. Gonidakis, F. Gorwood, P. Hudson, J. Kaprio, J. Kas, M. Keski-Rahonen, A. Kiezebrink, K. Knudsen, G.-P. Maj, M. Monteleone, A.M. Monteleone, P. Raevuori, A.H. Reichborn-Kjennerud, T. Tozzi, F. Tsitsika, A. van Elburg, A. Collier, D.A. Sullivan, P.F. Breen, G. Bulik, C.M. Zeggini, E. MCT Slof-Op 't Landt Eating Disorder Working Group of the Psychiatric Genomics Consortium
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GeneralLiterature_INTRODUCTORYANDSURVEY - Abstract
The fortieth author’s name was listed incorrectly. The correct presentation is A Keski-Rahkonen. © 2018, Springer Nature Limited.
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- 2018
5. Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
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Huckins, L.M. (L. M.), Hatzikotoulas, K. (K.), Southam, L. (Lorraine), Thornton, L.M. (L. M.), Steinberg, J. (J.), Aguilera-McKay, F. (F.), Treasure, J. (J.), Schmidt, U. (U.), Gunasinghe, C. (C.), Romero, A. (A.), Curtis, C. (C.), Rhodes, D. (D.), Moens, J. (J.), Kalsi, G. (G.), Dempster, D. (D.), Leung, R. (R.), Keohane, A. (A.), Burghardt, R. (R.), Ehrlich, S.M. (Stefan), Hebebrand, J. (Johannes), Hinney, A. (Anke), Ludolph, A.C. (Albert), Walton, E. (Esther), Deloukas, P. (Panagiotis), Hofman, A. (Albert), Palotie, A. (Aarno), Palta, P. (Priit), Rooij, F.J.A. (Frank) van, Stirrups, K. (Kathy), Adan, R.A.H. (Roger), Boni, C. (C.), Cone, R. (R.), Dedoussis, G.V. (George), Furth, E.F. (Eric) van, Gonidakis, F. (F.), Gorwood, P. (P.), Hudson, J. (J.), Kaprio, J. (J.), Kas, M.J.H. (Martien), Keski-Rahonen, A. (A.), Kiezebrink, K. (K.), Knudsen, G.-P. (G-P), Maj, M. (M.), Monteleone, A.M. (Alessio Maria), Monteleone, P. (P.), Raevuori, A.H. (A. H.), Reichborn-Kjennerud, T. (T.), Tozzi, F. (F.), Tsitsika, A. (Artemis), Elburg, A.A. (Annemarie) van, Collier, D.A. (David), Sullivan, P.F. (Patrick), Breen, G. (Gerome), Bulik, C.M. (C. M.), Zeggini, E. (E.), Huckins, L.M. (L. M.), Hatzikotoulas, K. (K.), Southam, L. (Lorraine), Thornton, L.M. (L. M.), Steinberg, J. (J.), Aguilera-McKay, F. (F.), Treasure, J. (J.), Schmidt, U. (U.), Gunasinghe, C. (C.), Romero, A. (A.), Curtis, C. (C.), Rhodes, D. (D.), Moens, J. (J.), Kalsi, G. (G.), Dempster, D. (D.), Leung, R. (R.), Keohane, A. (A.), Burghardt, R. (R.), Ehrlich, S.M. (Stefan), Hebebrand, J. (Johannes), Hinney, A. (Anke), Ludolph, A.C. (Albert), Walton, E. (Esther), Deloukas, P. (Panagiotis), Hofman, A. (Albert), Palotie, A. (Aarno), Palta, P. (Priit), Rooij, F.J.A. (Frank) van, Stirrups, K. (Kathy), Adan, R.A.H. (Roger), Boni, C. (C.), Cone, R. (R.), Dedoussis, G.V. (George), Furth, E.F. (Eric) van, Gonidakis, F. (F.), Gorwood, P. (P.), Hudson, J. (J.), Kaprio, J. (J.), Kas, M.J.H. (Martien), Keski-Rahonen, A. (A.), Kiezebrink, K. (K.), Knudsen, G.-P. (G-P), Maj, M. (M.), Monteleone, A.M. (Alessio Maria), Monteleone, P. (P.), Raevuori, A.H. (A. H.), Reichborn-Kjennerud, T. (T.), Tozzi, F. (F.), Tsitsika, A. (Artemis), Elburg, A.A. (Annemarie) van, Collier, D.A. (David), Sullivan, P.F. (Patrick), Breen, G. (Gerome), Bulik, C.M. (C. M.), and Zeggini, E. (E.)
- Abstract
The fortieth author's name was listed incorrectly. The correct presentation is A Keski-Rahkonen.
- Published
- 2018
- Full Text
- View/download PDF
6. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Author
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Huckins, L.M. (L. M.), Hatzikotoulas, K. (K.), Southam, L. (Lorraine), Thornton, L.M. (L. M.), Steinberg, J. (J.), Aguilera-Mckay, F. (F.), Treasure, J. (J.), Schmidt, U. (U.), Gunasinghe, C. (C.), Romero, A. (Atocha), Curtis, C. (C.), Rhodes, D. (D.), Moens, J. (J.), Kalsi, G. (G.), Dempster, D. (D.), Leung, R. (R.), Keohane, A. (A.), Burghardt, R. (R.), Ehrlich, S.M. (Stefan), Hebebrand, J. (Johannes), Hinney, A. (Anke), Ludolph, A.C. (Albert), Walton, E. (Esther), Deloukas, P. (P.), Hofman, A. (A.), Palotie, A. (A.), Palta, P. (Priit), Rooij, F.J.A. (Frank) van, Stirrups, K. (Kathy), Adan, R. (R.), Boni, C. (C.), Cone, R. (R.), Dedoussis, G.V. (George), Furth, E.F. (Eric) van, Gonidakis, F. (F.), Gorwood, P. (P.), Hudson, J. (J.), Kaprio, J. (J.), Kas, M.J.H. (Martien), Keski-Rahonen, A. (A.), Kiezebrink, K. (K.), Knudsen, G.-P. (G. P.), Slof-Op 'T Landt, M.C.T. (M. C.T.), Maj, M. (M.), Monteleone, A.M. (Alessio Maria), Monteleone, P. (P.), Raevuori, A.H. (A. H.), Reichborn-Kjennerud, T. (T.), Tozzi, F. (F.), Tsitsika, A. (A.), Elburg, A.A. (Annemarie) van, Collier, D.A. (David), Sullivan, P.F. (Patrick), Breen, G. (Gerome), Bulik, C.M. (C. M.), Zeggini, E. (E.), Huckins, L.M. (L. M.), Hatzikotoulas, K. (K.), Southam, L. (Lorraine), Thornton, L.M. (L. M.), Steinberg, J. (J.), Aguilera-Mckay, F. (F.), Treasure, J. (J.), Schmidt, U. (U.), Gunasinghe, C. (C.), Romero, A. (Atocha), Curtis, C. (C.), Rhodes, D. (D.), Moens, J. (J.), Kalsi, G. (G.), Dempster, D. (D.), Leung, R. (R.), Keohane, A. (A.), Burghardt, R. (R.), Ehrlich, S.M. (Stefan), Hebebrand, J. (Johannes), Hinney, A. (Anke), Ludolph, A.C. (Albert), Walton, E. (Esther), Deloukas, P. (P.), Hofman, A. (A.), Palotie, A. (A.), Palta, P. (Priit), Rooij, F.J.A. (Frank) van, Stirrups, K. (Kathy), Adan, R. (R.), Boni, C. (C.), Cone, R. (R.), Dedoussis, G.V. (George), Furth, E.F. (Eric) van, Gonidakis, F. (F.), Gorwood, P. (P.), Hudson, J. (J.), Kaprio, J. (J.), Kas, M.J.H. (Martien), Keski-Rahonen, A. (A.), Kiezebrink, K. (K.), Knudsen, G.-P. (G. P.), Slof-Op 'T Landt, M.C.T. (M. C.T.), Maj, M. (M.), Monteleone, A.M. (Alessio Maria), Monteleone, P. (P.), Raevuori, A.H. (A. H.), Reichborn-Kjennerud, T. (T.), Tozzi, F. (F.), Tsitsika, A. (A.), Elburg, A.A. (Annemarie) van, Collier, D.A. (David), Sullivan, P.F. (Patrick), Breen, G. (Gerome), Bulik, C.M. (C. M.), and Zeggini, E. (E.)
- Abstract
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10 -6), and rs7700147, an intergenic variant (P=2.93 × 10 -5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
- Published
- 2018
- Full Text
- View/download PDF
7. Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Author
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TN groep Adan, Circulatory Health, Brain, Huckins, L M, Hatzikotoulas, K, Southam, L, Thornton, L M, Steinberg, J, Aguilera-McKay, F, Treasure, J, Schmidt, U, Gunasinghe, C, Romero, A, Curtis, C, Rhodes, D, Moens, J, Kalsi, G, Dempster, D, Leung, R, Keohane, A, Burghardt, R, Ehrlich, S, Hebebrand, J, Hinney, A, Ludolph, A, Walton, E, Deloukas, P, Hofman, A, Palotie, A, Palta, P, van Rooij, F J A, Stirrups, K, Adan, R, Boni, C, Cone, R, Dedoussis, G, van Furth, E, Gonidakis, F, Gorwood, P, Hudson, J, Kaprio, J, Kas, M, Keski-Rahonen, A, Kiezebrink, K, Knudsen, G-P, Maj, M, Monteleone, A M, Monteleone, P, Raevuori, A H, Reichborn-Kjennerud, T, Tozzi, F, Tsitsika, A, van Elburg, A, MCT Slof-Op ’t Landt, TN groep Adan, Circulatory Health, Brain, Huckins, L M, Hatzikotoulas, K, Southam, L, Thornton, L M, Steinberg, J, Aguilera-McKay, F, Treasure, J, Schmidt, U, Gunasinghe, C, Romero, A, Curtis, C, Rhodes, D, Moens, J, Kalsi, G, Dempster, D, Leung, R, Keohane, A, Burghardt, R, Ehrlich, S, Hebebrand, J, Hinney, A, Ludolph, A, Walton, E, Deloukas, P, Hofman, A, Palotie, A, Palta, P, van Rooij, F J A, Stirrups, K, Adan, R, Boni, C, Cone, R, Dedoussis, G, van Furth, E, Gonidakis, F, Gorwood, P, Hudson, J, Kaprio, J, Kas, M, Keski-Rahonen, A, Kiezebrink, K, Knudsen, G-P, Maj, M, Monteleone, A M, Monteleone, P, Raevuori, A H, Reichborn-Kjennerud, T, Tozzi, F, Tsitsika, A, van Elburg, A, and MCT Slof-Op ’t Landt
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- 2018
8. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Author
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TN groep Adan, Brain, Circulatory Health, Translational Neuroscience, TN Onderwijs, Huckins, Laura M., Hatzikotoulas, Konstantinos, Southam, L., Thornton, Laura M., Steinberg, J.S., Aguilera-McKay, F, Treasure, J., Schmidt, U., Gunasinghe, C, Romero, Atocha, Curtis, Charles, Rhodes, Davina H., Bernelot Moens, Hein J, Kalsi, Gursharan, Dempster, D, Leung, R, Keohane, A, Burghardt, Roland, Ehrlich, S., Hebebrand, J., Hinney, A., Ludolph, A., Walton, Esther, Deloukas, P., Hofman, A., Palotie, A., Palta, P., Van Rooij, Frank J A, Stirrups, Kathleen, Adan, R, Boni, Claudette, Cone, Roger, Dedoussis, George, Furth, E.E., Gonidakis, Fragiskos, Gorwood, P., Hudson, Thomas J., Kaprio, Jaakko, Kas, M, Keski-Rahonen, A, Kiezebrink, K., Knudsen, Gun Peggy S., Slof-Op 't Landt, M C T, Maj, Mario, Monteleone, Alessio Maria, Monteleone, Palmiero, Raevuori, A H, Reichborn-Kjennerud, Ted, Tozzi, F., Tsitsika, Artemis, Eating Disorder Working Group of the Psychiatric Genomics Consortium, TN groep Adan, Brain, Circulatory Health, Translational Neuroscience, TN Onderwijs, Huckins, Laura M., Hatzikotoulas, Konstantinos, Southam, L., Thornton, Laura M., Steinberg, J.S., Aguilera-McKay, F, Treasure, J., Schmidt, U., Gunasinghe, C, Romero, Atocha, Curtis, Charles, Rhodes, Davina H., Bernelot Moens, Hein J, Kalsi, Gursharan, Dempster, D, Leung, R, Keohane, A, Burghardt, Roland, Ehrlich, S., Hebebrand, J., Hinney, A., Ludolph, A., Walton, Esther, Deloukas, P., Hofman, A., Palotie, A., Palta, P., Van Rooij, Frank J A, Stirrups, Kathleen, Adan, R, Boni, Claudette, Cone, Roger, Dedoussis, George, Furth, E.E., Gonidakis, Fragiskos, Gorwood, P., Hudson, Thomas J., Kaprio, Jaakko, Kas, M, Keski-Rahonen, A, Kiezebrink, K., Knudsen, Gun Peggy S., Slof-Op 't Landt, M C T, Maj, Mario, Monteleone, Alessio Maria, Monteleone, Palmiero, Raevuori, A H, Reichborn-Kjennerud, Ted, Tozzi, F., Tsitsika, Artemis, and Eating Disorder Working Group of the Psychiatric Genomics Consortium
- Published
- 2018
9. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Author
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Huckins, LM, Hatzikotoulas, K, Southam, L, Thornton, LM, Steinberg, J, Aguilera-McKay, F, Treasure, J, Schmidt, U, Gunasinghe, C, Romero, A, Curtis, C, Rhodes, D, Moens, J, Kalsi, G, Dempster, D, Leung, R, Keohane, A, Burghardt, R, Ehrlich, S, Hebebrand, J, Hinney, A, Ludolph, A, Walton, E, Deloukas, P, Hofman, Bert, Palotie, A, Palta, P, van Rooij, FJA, Stirrups, K, Adan, R, Boni, C, Cone, R, Dedoussis, G, Van Furth, E, Gonidakis, F, Gorwood, P, Hudson, J, Kaprio, J, Kas, M, Keski-Rahonen, A, Kiezebrink, K, Knudsen, GP, Slof-Op 't Landt, MCT, Maj, M, Monteleone, A M, Monteleone, P, Raevuori, AH, Reichborn-Kjennerud, T, Tozzi, F, Tsitsika, A, van Elburg, A, Collier, DA, Sullivan, PF, Breen, G, Bulik, CM, Zeggini, E, Huckins, LM, Hatzikotoulas, K, Southam, L, Thornton, LM, Steinberg, J, Aguilera-McKay, F, Treasure, J, Schmidt, U, Gunasinghe, C, Romero, A, Curtis, C, Rhodes, D, Moens, J, Kalsi, G, Dempster, D, Leung, R, Keohane, A, Burghardt, R, Ehrlich, S, Hebebrand, J, Hinney, A, Ludolph, A, Walton, E, Deloukas, P, Hofman, Bert, Palotie, A, Palta, P, van Rooij, FJA, Stirrups, K, Adan, R, Boni, C, Cone, R, Dedoussis, G, Van Furth, E, Gonidakis, F, Gorwood, P, Hudson, J, Kaprio, J, Kas, M, Keski-Rahonen, A, Kiezebrink, K, Knudsen, GP, Slof-Op 't Landt, MCT, Maj, M, Monteleone, A M, Monteleone, P, Raevuori, AH, Reichborn-Kjennerud, T, Tozzi, F, Tsitsika, A, van Elburg, A, Collier, DA, Sullivan, PF, Breen, G, Bulik, CM, and Zeggini, E
- Published
- 2018
10. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Author
-
Huckins, L M, Hatzikotoulas, K, Southam, L, Thornton, L M, Steinberg, J, Aguilera-McKay, F, Treasure, J, Schmidt, U, Gunasinghe, C, Romero, A, Curtis, C, Rhodes, D, Moens, J, Kalsi, G, Dempster, D, Leung, R, Keohane, A, Burghardt, R, Ehrlich, S, Hebebrand, J, Hinney, A, Ludolph, A, Walton, E, Deloukas, P, Hofman, A, Palotie, A, Palta, P, van Rooij, F J A, Stirrups, K, Adan, R, Boni, C, Cone, R, Dedoussis, G, van Furth, E, Gonidakis, F, Gorwood, P, Hudson, J, Kaprio, J, Kas, M, Keski-Rahonen, A, Kiezebrink, K, Knudsen, G-P, Slof-Op 't Landt, M C T, Maj, M, Monteleone, A M, Monteleone, P, Raevuori, A H, Reichborn-Kjennerud, T, Tozzi, F, Tsitsika, A, van Elburg, A, Collier, D A, Sullivan, P F, Breen, G, Bulik, C M, and Zeggini, E
- Abstract
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
- Published
- 2018
- Full Text
- View/download PDF
11. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
- Author
-
Palta, P., Monteleone, P., Hudson, J., Tozzi, F., Southam, L., Walton, E., Kas, M., Ludolph, A., Aguilera-Mckay, F., Keohane, A., Romero, A., Eating Disorder Working Group of the Psychiatric Genomics Consortium, Hinney, A., Zeggini, E., Rhodes, D., Huckins, L.M., Curtis, C., Cone, R., Burghardt, R., Hofman, A., Boni, C., Moens, J., Deloukas, P., Dempster, D., Adan, R., van Furth, E., Dedoussis, G., Sullivan, P.F., Palotie, A., Breen, G., Keski-Rahonen, A., Leung, R., Stirrups, K., van Rooij, F.J.A., Knudsen, G.-P., Maj, M., Hebebrand, J., Treasure, J., van Elburg, A., Bulik, C.M., Monteleone, A.M., Kalsi, G., Thornton, L.M., Raevuori, A.H., Kaprio, J., Gorwood, P., Ehrlich, S., Hatzikotoulas, K., Reichborn-Kjennerud, T., Gunasinghe, C., Kiezebrink, K., Tsitsika, A., Steinberg, J., Gonidakis, F., Slof-Op't Landt, M.C.T., Collier, D.A., and Schmidt, U.
- Subjects
3. Good health - Abstract
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P = 9.89 × 10− 6), and rs7700147, an intergenic variant (P = 2.93 × 10− 5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
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