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Your search keyword '"Aharodnikau, Uladzislau E."' showing total 21 results
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21 results on '"Aharodnikau, Uladzislau E."'

5. Nanoparticle drug delivery systems responsive to tumor microenvironment: Promising alternatives in the treatment of triple‐negative breast cancer

Author

Cao, Ye, primary, Meng, Fansu, additional, Cai, Tiange, additional, Gao, Lanwen, additional, Lee, Jaiwoo, additional, Solomevich, Sergey O., additional, Aharodnikau, Uladzislau E., additional, Guo, Tingting, additional, Lan, Meng, additional, Liu, Fengjie, additional, Li, Qianwen, additional, Viktor, Timoshenko, additional, Li, Detang, additional, and Cai, Yu, additional

Published
2024
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7. Corrigendum to “Porcupine-inspired microneedles coupled with an adhesive back patching as dressing for accelerating diabetic wound healing” [Acta Biomaterialia Volume 160, 1 April 2023, Pages 32-44]

Author

Liu, Tianqi, primary, Sun, Yanfang, additional, Jiang, Guohua, additional, Zhang, Wenjing, additional, Wang, Rui, additional, Nie, Lei, additional, Shavandi, Amin, additional, Yunusov, Khaydar E., additional, Aharodnikau, Uladzislau E., additional, and Solomevich, Sergey O., additional

Published
2023
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8. Red Blood Cell Membrane-Camouflaged Polydopamine and Bioactive Glass Composite Nanoformulation for Combined Chemo/Chemodynamic/Photothermal Therapy

Author

Zhang, Junhao, Sun, Yanfang, Ren, Luping, Chen, Lianxu, Nie, Lei, Shavandi, Amin, Yunusov, Khaydar E., Aharodnikau, Uladzislau E., Solomevich, Sergey O., and Jiang, Guohua

Abstract

Combinations of different therapeutic strategies, including chemotherapy (CT), chemodynamic therapy (CDT), and photothermal therapy (PTT), are needed to effectively address evolving drug resistance and the adverse effects of traditional cancer treatment. Herein, a camouflage composite nanoformulation (TCBG@PR), an antitumor agent (tubercidin, Tub) loaded into Cu-doped bioactive glasses (CBGs) and subsequently camouflaged by polydopamine (PDA), and red blood cell membranes (RBCm), was successfully constructed for targeted and synergetic antitumor therapies by combining CT of Tub, CDT of doped copper ions, and PTT of PDA. In addition, the TCBG@PRs composite nanoformulation was camouflaged with a red blood cell membrane (RBCm) to improve biocompatibility, longer blood retention times, and excellent cellular uptake properties. It integrated with long circulation and multimodal synergistic treatment (CT, CDT, and PTT) with the benefit of RBCms to avoid immune clearance for efficient targeted delivery to tumor locations, producing an “all-in-one” nanoplatform. In vivo results showed that the TCBG@PRs composite nanoformulation prolonged blood circulation and improved tumor accumulation. The combination of CT, CDT, and PTT therapies enhanced the antitumor therapeutic activity, and light-triggered drug release reduced systematic toxicity and increased synergistic antitumor effects.

Published
2024
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19. Transdermal delivery of allopurinol to acute hyperuricemic mice viapolymer microneedles for the regulation of serum uric acid levelsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2bm01836e

Author

Wang, Rui, Wang, Han, Jiang, Guohua, Sun, Yanfang, Liu, Tianqi, Nie, Lei, Shavandi, Amin, Yunusov, Khaydar E., Aharodnikau, Uladzislau E., and Solomevich, Sergey O.

Abstract

Allopurinol (AP) is widely used to treat hyperuricemia which may cause severe side effects upon oral administration. Alternative means for the treatment of hyperuricemia are demanded to simultaneously facilitate drug absorption, patient compliance, and fewer side effects. In this study, a new polymer microneedle (MN) system was developed for the transdermal delivery of AP to acute hyperuricemic mice. This study aims to achieve the controllable regulation of serum uric acid (SUA) levels with fewer side effects compared with oral administration. The matrix of polymer MNs consisted of polyvinylpyrrolidone (PVP) and polycaprolactone (PCL), in which the rapid dissolution of PVP offers a rapid dissolution of AP into the blood and the biodegradability of PCL resulting in a sustainable drug release behavior. An in vivostudy demonstrated that the AP-loaded MN system can effectively reduce the SUA levels as oral administration with lower side effects, which will be conducive to reducing the adverse reactions and improving the bioavailability of AP. This MN-mediated strategy can facilitate transcutaneous hyperuricemia treatment and provide a new alternative for the exploration of clinical treatment of hyperuricemia and improvement of patient compliance.

Published
2023
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20. Characterization of H3PO4/HNO3–NANO2 oxidized bacterial cellulose and its usage as a carrier for the controlled release of cephalexin.

Author

Solomevich, Sergey O., Dmitruk, Egor I., Aharodnikau, Uladzislau E., Salamevich, Daria A., Bychkovsky, Pavel M., Golub, Natalia V., and Yurkshtovich, Tatiana L.

Subjects
CELLULOSE, DRUG delivery systems, CARBOXYL group, GRAM-negative bacteria, DRUG carriers, ANTIBIOTICS
Abstract

Biocompatibility, biodegradation, good sorption characteristics, and unique structure of highly oxidized bacterial cellulose (OBC) are of great interest for the development of new drug delivery systems. In this study, OBC with 9.6, 13.0 and 19.5% carboxyl groups for 5, 20, and 48 h of synthesis, respectively, was successfully obtained using the HNO3/H3PO4–NaNO2. The results of morphological analysis showed that with an increase in the number of carboxyl groups, OBC fibers become thicker and rougher. Fourier-transform infrared spectroscopy showed the formation of carboxyl groups in the OBC after the oxidation reaction. The crystallinity of the samples according to X-Ray diffraction analysis decreased with increasing reaction time. The immobilization of cephalexin in the polymer matrix was studied in detail, it took 120 min to achieve balance in the solution with a concentration of 1 mg/ml, and the maximum amount of a sorbed antibiotic reached 43 mg/g. The drug release in vitro at 37 °C in PBS with pH 7.4 and 2.0 was prolonged. Various models were used to describe the release mechanism, the best of which was Ritger-Peppas with a diffusion exponent value ranging from 0.743 to 0.830, which explains the drug release mainly through non-Fickian diffusional release. The cephalexin-loaded OBC showed high antimicrobial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus. The structure and properties of the resulting highly oxidized cellulose make it an excellent candidate as a drug delivery carrier with prolonged antimicrobial drug release characteristics. [ABSTRACT FROM AUTHOR]

Published
2021
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21. Rational design of flexible microneedles coupled with CaO 2 @PDA-loaded nanofiber films for skin wound healing on diabetic rats.

Author

Zeng Z, Jiang G, Sun Y, Aharodnikau UE, Yunusov KE, Gao X, Liu T, and Solomevich SO

Subjects
Animals, Anti-Bacterial Agents pharmacology, Escherichia coli, Rats, Staphylococcus aureus, Wound Healing, Diabetes Mellitus, Experimental drug therapy, Metformin pharmacology, Nanofibers
Abstract

Skin ulcers are one of the complications of diabetes. At present, the treatment of diabetic skin wounds is still not satisfactory, and the efficiency of drug delivery is limited by the depth of penetration. Herein, a synergistically flexible microneedle dressing is presented for effectively promoting diabetic wound healing. Metformin, as an anti-diabetic drug, can be loaded into microneedles, which can effectively pierce into the skin of diabetic rats to trigger a response for regulating blood glucose levels. A novel multifunctional nanosystem CaO 2 @polydopamine (CaO 2 @PDA) was introduced into polycaprolactone and gelatin (PCL/Gel) electrospun nanofiber films as microneedle back patches to inhibit inflammation, provide oxygen, and absorb the excess exudate. Besides, the CaO 2 @PDA in back patches also provided effective antibacterial properties against both S. aureus and E. coli . Additionally, the as-fabricated flexible microneedle dressings loaded with metformin and CaO 2 @PDA nanoparticles demonstrated a high level of CD31 and low level of TNF-α, leading to accelerated diabetic skin-wound closure. These distinctive features demonstrate that our microneedle system can be a facile candidate for efficient wound healing in patients with diabetes and may be applied in various biomedical fields.

Published
2022
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