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2. Pharmacokinetics, safety, tolerability, and antiviral activity of dolutegravir dispersible tablets in infants and children with HIV-1 (IMPAACT P1093): results of an open-label, phase 1–2 trial

Author

Ruel, Theodore D, Acosta, Edward P, Liu, Jessica P, Gray, Kathryn P, George, Kathleen, Montañez, Nicole, Popson, Stephanie, Buchanan, Ann M, Bartlett, Mattie, Dayton, Dale, Anthony, Patricia, Brothers, Cynthia, Vavro, Cynthia, Singh, Rajendra, Koech, Lucy, Vhembo, Tichaona, Mmbaga, Blandina T, Pinto, Jorge A, Dobbels, Els FM, Archary, Moherndran, Chokephaibulkit, Kulkanya, Ounchanum, Pradthana, Deville, Jaime G, Hazra, Rohan, Townley, Ellen, Wiznia, Andrew, team, IMPAACT P1093, Carter, Michele F, Mansky, Hannah, Ferreira, Flavia F, Romeiro, Juliana, D'Angelo, Jessica, Williams, Ruth, Jundi, Fernanda, Cruz, Maria Letícia Santos, Sidi, Claude Leon, Kataike, Hajira, Owor, Maxensia, Ahimbisibwe, Grace Miriam, van Rensburg, Anita Janse, Andrea, Catherine V, Ponatshego, Ponego L, Budu, Marian, Tirelo, Lesedi, Masheto, Gaerolwe R, Raesi, Mpho S, Ramogodiri, Moakanyi, Chanthong, Jiraporn, Khamrong, Chintana, Aurpibul, Linda, Fairlie, Lee, Patel, Faeezah, Soma-Kashiram, Hamisha, Hanley, Sherika, Govender, Vani, Sturzbecher, Fernanda Tomé, Cervi, Maria Célia, Njau, Boniface, Matibe, Petronilla, Mukonowenzou, Ruvimbo, Marozva, Catherine C, Keter, Winnie C, Bii, Priscilla C, Cressey, Tim R, Sukrakanchana, Pra-ornsuda, Rungmaitree, Supattra, Pilotto, Jose Henrique, Fernandes, Luis Eduardo, and Gomes, Ivete Martins

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Sexually Transmitted Infections, HIV/AIDS, Prevention, Clinical Trials and Supportive Activities, Women's Health, Clinical Research, Pediatric AIDS, Infectious Diseases, 6.1 Pharmaceuticals, 5.1 Pharmaceuticals, 6.2 Cellular and gene therapies, Infection, Good Health and Well Being, Adolescent, Adult, Antiviral Agents, Child, Child, Preschool, Female, HIV Infections, HIV Integrase Inhibitors, HIV Seropositivity, HIV-1, Heterocyclic Compounds, 3-Ring, Humans, Infant, Male, Oxazines, Piperazines, Pyridones, RNA, Tablets, IMPAACT P1093 team, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundSafe and potent antiretroviral medications in child-friendly formulations are needed to treat young children living with HIV-1. We aimed to select dosing for a dispersible tablet formulation of dolutegravir that achieved pharmacokinetic exposures similar to those in adults, and was safe and well tolerated in young children.MethodsInternational Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT) P1093 is a phase 1-2 ongoing multicentre, open-label, non-comparative study of dolutegravir. A 5 mg dispersible tablet formulation of dolutegravir was studied in children aged 4 weeks to less than 6 years old, weighing at least 3 kg, with HIV RNA of greater than 1000 copies per mL and no previous treatment with integrase strand transfer inhibitor recruited from IMPAACT clinical research sites in Africa, the Americas, and Asia. Doses were selected on the basis of intensive pharmacokinetic evaluation on days 5-10, with safety and tolerability assessed up to 48 weeks. The primary objectives of this study are to evaluate the pharmacokinetics of dolutegravir in combination with optimised background therapy and to establish the dose of dolutegravir that achieves the targeted 24-h trough concentration and 24-h area under the curve for infants, children, and adolescents with HIV-1, to establish the safety and tolerability of dolutegravir at 24 and 48 weeks, and to select a dose that achieves similar exposure to the dolutegravir 50 mg once daily dose in adults. This analysis included participants treated with the proposed dose of dolutegravir dispersible tablets in two stages for each of three age cohorts. This trial is registered at ClinicalTrials.gov (NCT01302847) and is ongoing.FindingsWe recruited 181 participants from April 20, 2011, to Feb 19, 2020; of these, 96 received dolutegravir dispersible tablets. This analysis included 73 (35, 48% female) participants who received the final proposed dose with median (range) age of 1 year (0·1 to 6·0), weight (minimum-maximum) of 8·5 kg (3·7 to 18·5), plasma HIV-1 RNA concentration of 4·2 log10 copies per mL (2·1 to 7·0), and CD4% of 24·0% (0·3 to 49·0); 64 (87·7%) were treatment-experienced. The selected dose within each age cohort (≥2 years to

Published
2022

4. Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial

Author

Mehar (nee Abdulla), Amina Farhana, Abraham, Pattamukkil, Abrams, Elaine, Acero, Judith, Agaba, Gerald Muzorah, Ahimbisibwe, Grace, Ainebyoona, Barbara, Akobye, Winnie, Akhalwaya, Yasmeen, Akoojee, Nazim, Ali, Shabinah S., Amuge, Pauline, Andrea, Catherine, Muñoz Fernandez, Maria Angeles, Ankunda, Rogers, Rutebarika, Diana Antonia, Anugulruengkitt, Suvaporn, Apollo, Tsitsi, Archary, Moherndran, Arendze, Ronelle, Ategeka, Juliet, Atim, Eunice, Atwine, Lorna, Babiker, Abdel, Babirye, Sarah, Babu, Enock, Bagirigomwa, Edward, Baita, Angella, Balamusani, David, Baliram, Patsy, Baliruno, David, Ball, Colin, Balwa, Henry, Bamford, Alasdair, Bandi, Srini, Barker, Dominique, Barlow-Mosha, Linda, Bbuye, Dickson, Begum, Shazia, Behuhuma, Osee, Bernays, Sarah, Besigye, Rogers, Bester, Maria, Bhiri, Joyline, Bilardi, Davide, Bird, Kristien, Bollen, Pauline, Borg, Chiara, Borges Da Silva, Anne-Marie, Brown, Jackie, Bruno, Elena, Bunupuradah, Torsak, Burger, David, Buthelezi, Nomzamo, Bwakura-Dangarembizi, Mutsa, Byaruhanga, Africanus, Calvert, Joanna, Casey, Petronelle, Cassim, Haseena, Cebekhulu, Sphiwee, Chailert, Sanuphong, Chalermpantmetagul, Suwalai, Chamjamrat, Wanna, Chan, Man, Chandiwana, Precious, Chankun, Thannapat, Chanthaburanun, Sararut, Chanto, Nuttawut, Chidziva, Ennie, Chikowore, Minenhle, Chimanzi, Joy, Chinwong, Dujrudee, Chitongo, Stuart, Chitsamatanga, Moses, Choga, Joshua, Chutima, Duangrat, Clayden, Polly, Coelho, Alexandra, Colbers, Angela, Compagnucci, Alexandra, Constança Mendes, Ana, Conway, Magda, Cotton, Mark F, Crawley, Jane, Cressey, Tim R, Crisp, Jacky, Matos, Ana Cristina, Dadan, Sumaya, Daglish, Jacqui, Danaviah, Siva, Daniel, Tseleng, De Rossi, Anita, Denjanta, Sukanda, Dobbels, Els, Dowie, Maria, Dube, Prosper, Dube, Benedictor, Dudakia, Nimisha, Elwana, Alice, Epalza, Cristina, Eram, David, Erasmus, Juan, Erim, Peter, Escosa Garcia, Luis, Essack, Zaakirah, Estepa, Carolina, Etima, Monica, Fernandes, Alexandre, Fernandez, Maite, Fitzgerald, Felicity, Flynn, Jacquie, Ford, Deborah, Fortuny Guasch, Claudia, Foster, Caroline, Fourie, George, Fourie, Yolandie, Foxall, Sophie, Frank, Derusha, Gandhi, Kate, Garcia, India, Gartner, Kathleen, Gasa, Joshua, Gasa, Gugu, Giaquinto, Carlo, Gibb, Diana M, Gomez Rico, Coral, Gomez-Pena, Daniel, Gondo, Secrecy, Goodman, Anna, Gorreti Nakalema, Maria, Gozhora, Winnie, Greetanukroh, Pisut, Gregorio Maranon, Biobanco, Grossele, Tiziana, Gwande, Shamiso, Gwaze, Tapiwa, Gwenzi, Tsitsi, Hakim, James, Hakiza, Emmanuel, Kaka, Abdul Hamid, Harley, Ashley, Isaacs, Mornay, Isabirye, Richard, Ishemunyoro, Wilber, Jacobs, Tom, Jafta, Lungile, Jamil, Nasir, Janse van Rensburg, Anita Janse, Jeaven, Vinesh, Mellado Peña, Maria José, Jourdain, Gonzague, Juliet, Katabalwa, Jumpimai, Thidarat, Junkaew, Raungwit, Jupimai, Thidarat, Kaahwa, Winfred, Kabasonga, Mildred, Kaboggoza, Olivia, Kadhuba, Rose Jacqueline, Kaewbundit, Ampika, Kaewmamueng, Kanyanee, Kafufu, Bosco, Kakayi, Brenda, Kamboua, Phakamas, Kanjanavanit, Suparat, Kasangaki, Gladys, Kasipong, Naruporn, Kasozi, Miriam, Kataike, Hajira, Katemba, Chrispus, Kaudha, Elizabeth, Kekane, Nkata, Kekitiinwa, Adeodata R, Keminyeto, Edridah, Khamduang, Woottichai, Khamjakkaew, Warunee, Khamkon, Jiraporn, Khannak, Sasipass, Khatngam, Orapin, Khayanchoomnoom, Tassawan, Khumalo, Busi, Khunene, Mirriam, Khusuwan, Suwimon, Kibalama, Phionah, Kibenge, Robinah, Kirabira, Anthony, Kityo, Cissy M, Kiyimba, Lameck, Klein, Nigel, Klinprung, Soraya, Kobbe, Robin, Kobusingye, Olivia, Kobusungye, Josephine, Kongponoi, Areerat, Königs, Christoph, Koole, Olivier, Kouakam, Christelle, Krueduangkam, Nitinart, Kruenual, Namthip, Kunjaroenrut, Nuananong, Kyambadde, Raymonds, Kyobutungi, Priscilla, Kyomuhendo, Flavia, Kyomukama, Erinah, Lakha, Reshma, Langa, Cleopatra, Laomanit, Laddawan, Lebotsa, Emily, Leenasirimakul, Prattana, Lekku, Lawrence, Lensen, Sarah, Leroy, Valériane, Li, Jin, Liberty, Afaaf, Limplertjareanwanich, Juthamas, Little, Emma, Lugemwa, Abbas, Lutalo, Ezra, Jimenez, Jose Luis, Lyall, Hermione, MacDonald, Candice, Machache, Gladness, Madlala, Penelope, Madonsela, Tryphina, Maduna, Nomfundo, Maena, Joel, Mahanontharit, Apicha, Makanga, Collin, Makola, Candice, Makumbi, Shafic, Malgraaf, Lucille, Mamiane, Angelous, Mantkowski, Felicia, Mapfumo, Wendy, Marques, Laura, Mugagga, Agnes Mary, Maseko, Lindiwe, Masienyane, Tshepiso, Mathiba, Ruth, Matimba, Farai, Mawlana, Sajeeda, Mayanja, Emmanuel, Mayat, Fatima, Mbabazi, Ritah, Mbadaliga, Nokuthula, Mbasani, Faith, McClaughlin, Kathleen, McIlleron, Helen, Meethaisong, Watchara, Mendez Garcia, Patricia, Miwanda, Annet, Miranda, Carlota, Mkhize, Siphiwe, Mmolawa, Kgosimang, Mngqibisa, Rosie, Mohamed, Fatima, Moloantoa, Tumelo, Monametsi, Maletsatsi, Montero, Samuel, Moore, Cecilia L, Mosia, Rejoice, Moyo, Columbus, Mthethwa, Mumsy, Mudzingwa, Shepherd, Mudzviti, Tawona, Mujuru, Hilda, Mujyambere, Emmanuel, Mukanganiki, Trust, Mukisa Williams, Cynthia, Mulder, Mark, Mulima, Disan, Mulindwa, Alice, Mumbiro, Vivian, Mupambireyi, Zivai, Murciano Cabeza, Alba, Murungi, Herbert, Murungu, Dorothy, Musarurwa, Sandra, Musiime, Victor, Musiime, Alex V, Musisi, Maria, Musoke, Philippa, Musoke Nakirya, Barbara, Musoro, Godfrey, Musumba, Sharif, Mustafa, Sobia, Mutsai, Shirley, Mwesigwa Rubondo, Phyllis, Naabalamba, Mariam, Nagawa, Immaculate, Naidoo, Allemah, Nakabuye, Shamim, Nakabuye, Sarah, Nakalanzi, Sarah, Nalubwama, Justine, Nalugo, Annet, Nalusiba, Stella, Namajja, Clementine, Namanda, Sylvia, Namayanja, Paula, Nambi, Esther, Namuddu, Rachael Kikabi, Namukwaya, Stella, Namuli, Florence, Namusanje, Josephine, Namwanje, Rosemary, Nanan-kanjee, Anusha, Nanduudu, Annet, Nankunda, Charity, Baddokwaya, Joanita Nankya, Nannungi, Maria, Nansamba, Winnie, Nanthapisal, Kesdao, Nanyonjo, Juliet, Na-Rajsima, Sathaporn, Nasaazi, Claire, Nascimento, Helena, Nastouli, Eleni, Songtaweesin, Wipaporn Natalie, Nathoo, Kusum, Natuhurira, Ian, Nazzinda, Rashidah, Ncgaba, Thabisa, Ndigendawani, Milly, Ndlovu, Makhosonke, Nentsa, Georgina, Ngampiyaskul, Chaiwat, Ngcobo, Ntombenhle, Ngo Giang Huong, Nicole, Ngwaru, Pia, Nhema, Ruth, Ninsiima, Emily, Ninsiima, Gloria, Nkalo Phiri, Misheck, Noguera Julian, Antoni, Nolan, Monica, Noppakaorattanamanee, Thornthun, Nsibuka Kisekka, Muzamil, Nsirim, Eniola, Nundlal, Rashina, Nunes, Rosita, Nyantsa, Lungile, Nyati, Mandisa, O'Riordan, Sean, Ocitti Labeja, Paul, Odoch, Denis, Oguntimehin, Rachel, Ojok, Martin, Onen, Geoffrey, Orange, Wilma, Ounchanum, Pradthana, Ouma, Benson, Padrao, Andreia, Pako, Deborah, Parker, Anna, Pasko-Szcech, Malgorzata, Patel, Reena, Peongjakta, Rukchanok, Petpranee, Turian, Phillips, Tasmin, Philps, Jackie, Picault, Laura, Pieterse, Sonja, Pinheiro, Helena, Pongprapass, Supawadee, Pozniak, Anton, Prendergast, Andrew, Prieto Tato, Luis, Puangmalai, Patcharee, Puthanakit, Thanyawee, Rakgokong, Modiehi, Ramos, Helena, Ramsagar, Nastassja, Rau, Cornelius, Riault, Yoann, Rojo Conejo, Pablo, Clark, Basiimwa Roy, Rubanga, Eddie, Rubinga, Baker, Ruklao, Chutima, Runarassamee, Pattira, Saenjum, Chalermpong, Saewtrakool, Chayakorn, Saidi, Yacine, Sainz Costa, Talia, Saisaengjan, Chutima, Sakwa, Rebecca, Sarfati, Tatiana, Sbisi, Noshalaza, Scheppers, Dihedile, Schultze-Strasser, Stephan, Schulze-Sturm, Ulf, Scott, Karen, Seeley, Janet, Serunjogi, Robert, Sewnarain, Leora, Shakeshaft, Clare, Sidhoo, Subashinie, Shibemba, Mercy, Shingadia, Delane, Singh, Sheleika, Sirirungsi, Wasna, Sithebe, Sibongile, Smit, Theresa, Smith, Kurt, Smuts, Marlize, Spyer, Moira, Sripaoraya, Worathip, Srirompotong, Ussanee, Srisuk, Warunee, Ssenyonga, Mark, Sudsaard, Patamawadee, Sukrakanchana, Praornsuda, Tearsansern, Pathanee, Teixeira, Carla, Than-in-at, Kanchana, Thapwai, Thitiwat, Thaweesombat, Yupawan, Thewsoongnoen, Jutarat, Thiébaut, Rodolphe, Thomason, Margaret, Thrasyvoulou, Laura, Thungkham, Khanungnit, Tikabibamu, Judith, Tinago, Gloria, Trairat, Ketmookda, Tudor-Williams, Gareth, Tukamushaba, Mercy, Tukwasibwe, Deogratiuos, Tumusiime, Julius, Tuna, Joana, Turkova, Anna, Turner, Rebecca, Udomvised, Arttasid, Vadee, Aasia, Van Huyssteen, Hesti, Van Looy, Nadine, Variava, Ebrahim, Vaughan-Gordon, Yvonne, Vecchia, Giulio, Violari, Avy, Vowden, Richard, Waalewijn, Hylke, Wampamba, Rebecca, Welch, Steve, Weller, Ian, Weza, Sibusisiwe, White, Ellen, White, Ian, Widuch, Kaja, Wilkes, Helen, Wimonklang, Sookpanee, Wynne, Ben, Yingyong, Pacharaporn, Nakawungu, Zaam Zinda, Zuidewind, Peter, Ahimbisibwe, Grace Miriam, Mosia, Nozibusiso Rejoice, Fortuny, Clàudia, Bwakura-Dangarembizi, Mutsa F, Mujuru, Hilda A, Kityo, Cissy, Ferrand, Rashida A, and Rojo, Pablo

Published
2023
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5. Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial

Author

Mehar (nee Abdulla), Amina Farhana, Abraham, Pattamukkil, Abrams, Elaine, Acero, Judith, Agaba, Gerald Muzorah, Ahimbisibwe, Grace, Ainebyoona, Barbara, Akobye, Winnie, Akhalwaya, Yasmeen, Akoojee, Nazim, Ali, Shabinah S., Amuge, Pauline, Andrea, Catherine, Muñoz Fernandez, Maria Angeles, Ankunda, Rogers, Rutebarika, Diana Antonia, Anugulruengkitt, Suvaporn, Apollo, Tsitsi, Archary, Moherndran, Arendze, Ronelle, Ategeka, Juliet, Atim, Eunice, Atwine, Lorna, Babiker, Abdel, Babirye, Sarah, Babu, Enock, Bagirigomwa, Edward, Baita, Angella, Balamusani, David, Baliram, Patsy, Baliruno, David, Ball, Colin, Balwa, Henry, Bamford, Alasdair, Bandi, Srini, Barker, Dominique, Barlow-Mosha, Linda, Bbuye, Dickson, Begum, Shazia, Behuhuma, Osee, Bernays, Sarah, Besigye, Rogers, Bester, Maria, Bhiri, Joyline, Bilardi, Davide, Bird, Kristien, Bollen, Pauline, Borg, Chiara, Borges Da Silva, Anne-Marie, Brown, Jackie, Bruno, Elena, Bunupuradah, Torsak, Burger, David, Buthelezi, Nomzamo, Bwakura-Dangarembizi, Mutsa, Byaruhanga, Africanus, Calvert, Joanna, Casey, Petronelle, Cassim, Haseena, Cebekhulu, Sphiwee, Chailert, Sanuphong, Chalermpantmetagul, Suwalai, Chamjamrat, Wanna, Chan, Man, Chandiwana, Precious, Chankun, Thannapat, Chanthaburanun, Sararut, Chanto, Nuttawut, Chidziva, Ennie, Chikowore, Minenhle, Chimanzi, Joy, Chinwong, Dujrudee, Chitongo, Stuart, Chitsamatanga, Moses, Choga, Joshua, Chutima, Duangrat, Clayden, Polly, Coelho, Alexandra, Colbers, Angela, Compagnucci, Alexandra, Constança Mendes, Ana, Conway, Magda, Cotton, Mark F., Crawley, Jane, Cressey, Tim R., Crisp, Jacky, Matos, Ana Cristina, Dadan, Sumaya, Daglish, Jacqui, Danaviah, Siva, Daniel, Tseleng, De Rossi, Anita, Denjanta, Sukanda, Dobbels, Els, Dowie, Maria, Dube, Prosper, Dube, Benedictor, Dudakia, Nimisha, Elwana, Alice, Epalza, Cristina, Eram, David, Erasmus, Juan, Erim, Peter, Escosa Garcia, Luis, Essack, Zaakirah, Estepa, Carolina, Etima, Monica, Fernandes, Alexandre, Fernandez, Maite, Fitzgerald, Felicity, Flynn, Jacquie, Ford, Deborah, Fortuny Guasch, Claudia, Foster, Caroline, Fourie, George, Fourie, Yolandie, Foxall, Sophie, Frank, Derusha, Gandhi, Kate, Garcia, India, Gartner, Kathleen, Gasa, Joshua, Gasa, Gugu, Giaquinto, Carlo, Gibb, Diana M., Gomez Rico, Coral, Gomez-Pena, Daniel, Gondo, Secrecy, Goodman, Anna, Gorreti Nakalema, Maria, Gozhora, Winnie, Greetanukroh, Pisut, Gregorio Maranon, Biobanco, Grossele, Tiziana, Gwande, Shamiso, Gwaze, Tapiwa, Gwenzi, Tsitsi, Hakim, James, Hakiza, Emmanuel, Kaka, Abdul Hamid, Harley, Ashley, Isaacs, Mornay, Isabirye, Richard, Ishemunyoro, Wilber, Jacobs, Tom, Jafta, Lungile, Jamil, Nasir, Janse van Rensburg, Anita Janse, Jeaven, Vinesh, Mellado Peña, Maria José, Jourdain, Gonzague, Juliet, Katabalwa, Jumpimai, Thidarat, Junkaew, Raungwit, Jupimai, Thidarat, Kaahwa, Winfred, Kabasonga, Mildred, Kaboggoza, Olivia, Kadhuba, Rose Jacqueline, Kaewbundit, Ampika, Kaewmamueng, Kanyanee, Kafufu, Bosco, Kakayi, Brenda, Kamboua, Phakamas, Kanjanavanit, Suparat, Kasangaki, Gladys, Kasipong, Naruporn, Kasozi, Miriam, Kataike, Hajira, Katemba, Chrispus, Kaudha, Elizabeth, Kekane, Nkata, Kekitiinwa, Adeodata R., Keminyeto, Edridah, Khamduang, Woottichai, Khamjakkaew, Warunee, Khamkon, Jiraporn, Khannak, Sasipass, Khatngam, Orapin, Khayanchoomnoom, Tassawan, Khumalo, Busi, Khunene, Mirriam, Khusuwan, Suwimon, Kibalama, Phionah, Kibenge, Robinah, Kirabira, Anthony, Kityo, Cissy M., Kiyimba, Lameck, Klein, Nigel, Klinprung, Soraya, Kobbe, Robin, Kobusingye, Olivia, Kobusungye, Josephine, Kongponoi, Areerat, Königs, Christoph, Koole, Olivier, Kouakam, Christelle, Krueduangkam, Nitinart, Kruenual, Namthip, Kunjaroenrut, Nuananong, Kyambadde, Raymonds, Kyobutungi, Priscilla, Kyomuhendo, Flavia, Kyomukama, Erinah, Lakha, Reshma, Langa, Cleopatra, Laomanit, Laddawan, Lebotsa, Emily, Leenasirimakul, Prattana, Lekku, Lawrence, Lensen, Sarah, Leroy, Valériane, Li, Jin, Liberty, Afaaf, Limplertjareanwanich, Juthamas, Little, Emma, Lugemwa, Abbas, Lutalo, Ezra, Jimenez, Jose Luis, Lyall, Hermione, MacDonald, Candice, Machache, Gladness, Madlala, Penelope, Madonsela, Tryphina, Maduna, Nomfundo, Maena, Joel, Mahanontharit, Apicha, Makanga, Collin, Makola, Candice, Makumbi, Shafic, Malgraaf, Lucille, Mamiane, Angelous, Mantkowski, Felicia, Mapfumo, Wendy, Marques, Laura, Mugagga, Agnes Mary, Maseko, Lindiwe, Masienyane, Tshepiso, Mathiba, Ruth, Matimba, Farai, Mawlana, Sajeeda, Mayanja, Emmanuel, Mayat, Fatima, Mbabazi, Ritah, Mbadaliga, Nokuthula, Mbasani, Faith, McClaughlin, Kathleen, McIlleron, Helen, Meethaisong, Watchara, Mendez Garcia, Patricia, Miwanda, Annet, Miranda, Carlota, Mkhize, Siphiwe, Mmolawa, Kgosimang, Mngqibisa, Rosie, Mohamed, Fatima, Moloantoa, Tumelo, Monametsi, Maletsatsi, Montero, Samuel, Moore, Cecilia L., Mosia, Rejoice, Moyo, Columbus, Mthethwa, Mumsy, Mudzingwa, Shepherd, Mudzviti, Tawona, Mujuru, Hilda, Mujyambere, Emmanuel, Mukanganiki, Trust, Mukisa Williams, Cynthia, Mulder, Mark, Mulima, Disan, Mulindwa, Alice, Mumbiro, Vivian, Mupambireyi, Zivai, Murciano Cabeza, Alba, Murungi, Herbert, Murungu, Dorothy, Musarurwa, Sandra, Musiime, Victor, Musiime, Alex V., Musisi, Maria, Musoke, Philippa, Musoke Nakirya, Barbara, Musoro, Godfrey, Musumba, Sharif, Mustafa, Sobia, Mutsai, Shirley, Mwesigwa Rubondo, Phyllis, Naabalamba, Mariam, Nagawa, Immaculate, Naidoo, Allemah, Nakabuye, Shamim, Nakabuye, Sarah, Nakalanzi, Sarah, Nalubwama, Justine, Nalugo, Annet, Nalusiba, Stella, Namajja, Clementine, Namanda, Sylvia, Namayanja, Paula, Nambi, Esther, Namuddu, Rachael Kikabi, Namukwaya, Stella, Namuli, Florence, Namusanje, Josephine, Namwanje, Rosemary, Nanan-kanjee, Anusha, Nanduudu, Annet, Nankunda, Charity, Baddokwaya, Joanita Nankya, Nannungi, Maria, Nansamba, Winnie, Nanthapisal, Kesdao, Nanyonjo, Juliet, Na-Rajsima, Sathaporn, Nasaazi, Claire, Nascimento, Helena, Nastouli, Eleni, Songtaweesin, Wipaporn Natalie, Nathoo, Kusum, Natuhurira, Ian, Nazzinda, Rashidah, Ncgaba, Thabisa, Ndigendawani, Milly, Ndlovu, Makhosonke, Nentsa, Georgina, Ngampiyaskul, Chaiwat, Ngcobo, Ntombenhle, Ngo Giang Huong, Nicole, Ngwaru, Pia, Nhema, Ruth, Ninsiima, Emily, Ninsiima, Gloria, Nkalo Phiri, Misheck, Noguera Julian, Antoni, Nolan, Monica, Noppakaorattanamanee, Thornthun, Nsibuka Kisekka, Muzamil, Nsirim, Eniola, Nundlal, Rashina, Nunes, Rosita, Nyantsa, Lungile, Nyati, Mandisa, O'Riordan, Sean, Ocitti Labeja, Paul, Odoch, Denis, Oguntimehin, Rachel, Ojok, Martin, Onen, Geoffrey, Orange, Wilma, Ounchanum, Pradthana, Ouma, Benson, Padrao, Andreia, Pako, Deborah, Parker, Anna, Pasko-Szcech, Malgorzata, Patel, Reena, Peongjakta, Rukchanok, Petpranee, Turian, Phillips, Tasmin, Philps, Jackie, Picault, Laura, Pieterse, Sonja, Pinheiro, Helena, Pongprapass, Supawadee, Pozniak, Anton, Prendergast, Andrew, Prieto Tato, Luis, Puangmalai, Patcharee, Puthanakit, Thanyawee, Rakgokong, Modiehi, Ramos, Helena, Ramsagar, Nastassja, Rau, Cornelius, Riault, Yoann, Rojo Conejo, Pablo, Clark, Basiimwa Roy, Rubanga, Eddie, Rubinga, Baker, Ruklao, Chutima, Runarassamee, Pattira, Saenjum, Chalermpong, Saewtrakool, Chayakorn, Saidi, Yacine, Sainz Costa, Talia, Saisaengjan, Chutima, Sakwa, Rebecca, Sarfati, Tatiana, Sbisi, Noshalaza, Scheppers, Dihedile, Schultze-Strasser, Stephan, Schulze-Sturm, Ulf, Scott, Karen, Seeley, Janet, Serunjogi, Robert, Sewnarain, Leora, Shakeshaft, Clare, Sidhoo, Subashinie, Shibemba, Mercy, Shingadia, Delane, Singh, Sheleika, Sirirungsi, Wasna, Sithebe, Sibongile, Smit, Theresa, Smith, Kurt, Smuts, Marlize, Spyer, Moira, Sripaoraya, Worathip, Srirompotong, Ussanee, Srisuk, Warunee, Ssenyonga, Mark, Sudsaard, Patamawadee, Sukrakanchana, Praornsuda, Tearsansern, Pathanee, Teixeira, Carla, Than-in-at, Kanchana, Thapwai, Thitiwat, Thaweesombat, Yupawan, Thewsoongnoen, Jutarat, Thiébaut, Rodolphe, Thomason, Margaret, Thrasyvoulou, Laura, Thungkham, Khanungnit, Tikabibamu, Judith, Tinago, Gloria, Trairat, Ketmookda, Tudor-Williams, Gareth, Tukamushaba, Mercy, Tukwasibwe, Deogratiuos, Tumusiime, Julius, Tuna, Joana, Turkova, Anna, Turner, Rebecca, Udomvised, Arttasid, Vadee, Aasia, Van Huyssteen, Hesti, Van Looy, Nadine, Variava, Ebrahim, Vaughan-Gordon, Yvonne, Vecchia, Giulio, Violari, Avy, Vowden, Richard, Waalewijn, Hylke, Wampamba, Rebecca, Welch, Steve, Weller, Ian, Weza, Sibusisiwe, White, Ellen, White, Ian, Widuch, Kaja, Wilkes, Helen, Wimonklang, Sookpanee, Wynne, Ben, Yingyong, Pacharaporn, Nakawungu, Zaam Zinda, Zuidewind, Peter, Chan, Man K, Bollen, Pauline D J, Bwakura-Dangarembizi, Mutsa F, Kekitiinwa, Adeodata R, Cotton, Mark F, Ahimbisibwe, Grace Miriam, Ali, Shabinah, Kityo, Cissy M, Ferrand, Rashida A, Gibb, Diana M, and Burger, David M

Published
2022
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6. Pharmacokinetics, safety, tolerability, and antiviral activity of dolutegravir dispersible tablets in infants and children with HIV-1 (IMPAACT P1093): results of an open-label, phase 1–2 trial

Author

Deville, Jaime G, Carter, Michele F, Mansky, Hannah, Pinto, Jorge A, Ferreira, Flavia F, Romeiro, Juliana, D'Angelo, Jessica, Williams, Ruth, Jundi, Fernanda, Cruz, Maria Letícia Santos, Sidi, Claude Leon, Kataike, Hajira, Owor, Maxensia, Ahimbisibwe, Grace Miriam, van Rensburg, Ms Anita Janse, Andrea, Catherine V, Ponatshego, Ponego L, Budu, Marian, Tirelo, Lesedi, Masheto, Gaerolwe R, Raesi, Mpho S., Ramogodiri, Moakanyi, Chanthong, Jiraporn, Khamrong, Chintana, Aurpibul, Linda, Fairlie, Lee, Patel, Faeezah, Soma-Kashiram, Hamisha, Archary, Moherndran, Hanley, Sherika, Govender, Vani, Sturzbecher, Fernanda Tomé, Cervi, Maria Célia, Mmbaga, Blandina T, Njau, Boniface, Matibe, Petronilla, Mukonowenzou, Ruvimbo, Marozva, Catherine C, Keter, Winnie C, Bii, Priscilla C, Ounchanum, Pradthana, Cressey, Tim R, Sukrakanchana, Pra-ornsuda, Chokephaibulkit, Kulkanya, Rungmaitree, Supattra, Pilotto, Jose Henrique, Fernandes, Luis Eduardo, Gomes, Ivete Martins, Ruel, Theodore D, Acosta, Edward P, Liu, Jessica P, Gray, Kathryn P, George, Kathleen, Montañez, Nicole, Popson, Stephanie, Buchanan, Ann M, Bartlett, Mattie, Dayton, Dale, Anthony, Patricia, Brothers, Cynthia, Vavro, Cynthia, Singh, Rajendra, Koech, Lucy, Vhembo, Tichaona, Dobbels, Els F M, Hazra, Rohan, Townley, Ellen, and Wiznia, Andrew

Published
2022
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7. Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume levels among children and adolescents with HIV: a sub‐study of the ODYSSEY randomized controlled trial

Author

Barlow‐Mosha, Linda Namutebi, Ahimbisibwe, Grace Miriam, Chappell, Elizabeth, Amuge, Pauline Mary, Nanduudu, Annet, Kaudha, Elizabeth, Amukele, Timothy, Balamusani, David, Kafufu, Bosco, Nimwesiga, Audrey, Kataike, Hajira, Namwanje, Rosemary, Kasangaki, Gladys, Mulindwa, Alice, Muzorah, Gerald Agaba, Bbuye, Dickson, Musiime, Victor, Mujyambere, Emmanuel, Ssenyonga, Mark, Mulima, Disan, Kyambadde, Raymonds Crespo, Namusanje, Josephine, Isabirye, Richard, Nabalamba, Mariam, Nakirya, Barbara Musoke, Kityo, Cissy, Kekitiinwa, Adeodata R., Giaquinto, Carlo, Copp, Andrew, Gibb, Diana M., Ford, Deborah, Musoke, Philippa, and Turkova, Anna

Subjects
Folic acid -- Health aspects, HIV infection in children -- Drug therapy, Vitamin B12 -- Health aspects, Drug interactions -- Observations, Health
Abstract

: Introduction: Dolutegravir‐based antiretroviral therapy (ART) is the preferred antiretroviral treatment for children and adolescents living with HIV. A large surveillance study in Botswana previously raised concerns about an association between pre‐conception dolutegravir and neural tube defects. Before these concerns were subsequently resolved, we set up a sub‐study to look at the effect of dolutegravir on levels of folate and vitamin B12 in children and adolescents within the randomized ODYSSEY trial, as folate and vitamin B12 are known to play a crucial role in neural tube development. Methods: We conducted the sub‐study among Ugandan ODYSSEY participants and compared folate and vitamin B12 between children randomized to dolutegravir‐based ART (DTG) and non‐dolutegravir‐based standard‐of‐care treatment (SOC). Plasma folate was measured at enrolment and week 4 on stored samples; in addition, plasma and red blood cell (RBC) folate and vitamin B12 were assayed at week ≥96 in prospectively collected samples. RBC mean corpuscular volume (MCV) was measured 24‐weekly in all ODYSSEY participants. Samples analysed in the sub‐study were collected between September 2016 and October 2020. Results: A total of 229 children aged ≥6 years were included in the sub‐study with median age at trial enrolment of 12.3 (interquartile range [IQR] 9.0, 14.7) years, and CD4 count of 501 (IQR 228, 695); 112 (49%) children were male. Most participants (225/229, 98%) had plasma folate results at enrolment and 214 (93%) children had results available for RBC folate, vitamin B12 and plasma folate at week ≥96. MCV results were analysed on 679 children aged ≥6 years enrolled in ODYSSEY. At week 4, mean plasma folate was significantly higher in the dolutegravir arm than in SOC (difference [DTG‐SOC] 1.6 ng/ml, 95% CI 0.8, 2.3; p Conclusions: Plasma and RBC folate levels were higher in children and adolescents receiving dolutegravir‐based ART than on other ART regimens. Further studies are needed to clarify the mechanisms of these interactions and the clinical implications of increased blood folate levels., INTRODUCTION Dolutegravir‐based antiretroviral therapy (ART) has become the preferred treatment option for children living with HIV due to superior efficacy and similar safety compared to non‐dolutegravir‐based ART [1]. A number [...]

Published
2023
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8. Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial

Author

Turkova, Anna, primary, White, Ellen, additional, Kekitiinwa, Adeodata R, additional, Mumbiro, Vivian, additional, Kaudha, Elizabeth, additional, Liberty, Afaaf, additional, Ahimbisibwe, Grace Miriam, additional, Moloantoa, Tumelo, additional, Srirompotong, Ussanee, additional, Mosia, Nozibusiso Rejoice, additional, Puthanakit, Thanyawee, additional, Kobbe, Robin, additional, Fortuny, Clàudia, additional, Kataike, Hajira, additional, Bbuye, Dickson, additional, Na-Rajsima, Sathaporn, additional, Coelho, Alexandra, additional, Lugemwa, Abbas, additional, Bwakura-Dangarembizi, Mutsa F, additional, Klein, Nigel, additional, Mujuru, Hilda A, additional, Kityo, Cissy, additional, Cotton, Mark F, additional, Ferrand, Rashida A, additional, Giaquinto, Carlo, additional, Rojo, Pablo, additional, Violari, Avy, additional, Gibb, Diana M, additional, Ford, Deborah, additional, Mehar (nee Abdulla), Amina Farhana, additional, Abraham, Pattamukkil, additional, Abrams, Elaine, additional, Acero, Judith, additional, Agaba, Gerald Muzorah, additional, Ahimbisibwe, Grace, additional, Ainebyoona, Barbara, additional, Akobye, Winnie, additional, Akhalwaya, Yasmeen, additional, Akoojee, Nazim, additional, Ali, Shabinah S., additional, Amuge, Pauline, additional, Andrea, Catherine, additional, Muñoz Fernandez, Maria Angeles, additional, Ankunda, Rogers, additional, Rutebarika, Diana Antonia, additional, Anugulruengkitt, Suvaporn, additional, Apollo, Tsitsi, additional, Archary, Moherndran, additional, Arendze, Ronelle, additional, Ategeka, Juliet, additional, Atim, Eunice, additional, Atwine, Lorna, additional, Babiker, Abdel, additional, Babirye, Sarah, additional, Babu, Enock, additional, Bagirigomwa, Edward, additional, Baita, Angella, additional, Balamusani, David, additional, Baliram, Patsy, additional, Baliruno, David, additional, Ball, Colin, additional, Balwa, Henry, additional, Bamford, Alasdair, additional, Bandi, Srini, additional, Barker, Dominique, additional, Barlow-Mosha, Linda, additional, Begum, Shazia, additional, Behuhuma, Osee, additional, Bernays, Sarah, additional, Besigye, Rogers, additional, Bester, Maria, additional, Bhiri, Joyline, additional, Bilardi, Davide, additional, Bird, Kristien, additional, Bollen, Pauline, additional, Borg, Chiara, additional, Borges Da Silva, Anne-Marie, additional, Brown, Jackie, additional, Bruno, Elena, additional, Bunupuradah, Torsak, additional, Burger, David, additional, Buthelezi, Nomzamo, additional, Bwakura-Dangarembizi, Mutsa, additional, Byaruhanga, Africanus, additional, Calvert, Joanna, additional, Casey, Petronelle, additional, Cassim, Haseena, additional, Cebekhulu, Sphiwee, additional, Chailert, Sanuphong, additional, Chalermpantmetagul, Suwalai, additional, Chamjamrat, Wanna, additional, Chan, Man, additional, Chandiwana, Precious, additional, Chankun, Thannapat, additional, Chanthaburanun, Sararut, additional, Chanto, Nuttawut, additional, Chidziva, Ennie, additional, Chikowore, Minenhle, additional, Chimanzi, Joy, additional, Chinwong, Dujrudee, additional, Chitongo, Stuart, additional, Chitsamatanga, Moses, additional, Choga, Joshua, additional, Chutima, Duangrat, additional, Clayden, Polly, additional, Colbers, Angela, additional, Compagnucci, Alexandra, additional, Constança Mendes, Ana, additional, Conway, Magda, additional, Crawley, Jane, additional, Cressey, Tim R, additional, Crisp, Jacky, additional, Matos, Ana Cristina, additional, Dadan, Sumaya, additional, Daglish, Jacqui, additional, Danaviah, Siva, additional, Daniel, Tseleng, additional, De Rossi, Anita, additional, Denjanta, Sukanda, additional, Dobbels, Els, additional, Dowie, Maria, additional, Dube, Prosper, additional, Dube, Benedictor, additional, Dudakia, Nimisha, additional, Elwana, Alice, additional, Epalza, Cristina, additional, Eram, David, additional, Erasmus, Juan, additional, Erim, Peter, additional, Escosa Garcia, Luis, additional, Essack, Zaakirah, additional, Estepa, Carolina, additional, Etima, Monica, additional, Fernandes, Alexandre, additional, Fernandez, Maite, additional, Fitzgerald, Felicity, additional, Flynn, Jacquie, additional, Fortuny Guasch, Claudia, additional, Foster, Caroline, additional, Fourie, George, additional, Fourie, Yolandie, additional, Foxall, Sophie, additional, Frank, Derusha, additional, Gandhi, Kate, additional, Garcia, India, additional, Gartner, Kathleen, additional, Gasa, Joshua, additional, Gasa, Gugu, additional, Gomez Rico, Coral, additional, Gomez-Pena, Daniel, additional, Gondo, Secrecy, additional, Goodman, Anna, additional, Gorreti Nakalema, Maria, additional, Gozhora, Winnie, additional, Greetanukroh, Pisut, additional, Gregorio Maranon, Biobanco, additional, Grossele, Tiziana, additional, Gwande, Shamiso, additional, Gwaze, Tapiwa, additional, Gwenzi, Tsitsi, additional, Hakim, James, additional, Hakiza, Emmanuel, additional, Kaka, Abdul Hamid, additional, Harley, Ashley, additional, Isaacs, Mornay, additional, Isabirye, Richard, additional, Ishemunyoro, Wilber, additional, Jacobs, Tom, additional, Jafta, Lungile, additional, Jamil, Nasir, additional, Janse van Rensburg, Anita Janse, additional, Jeaven, Vinesh, additional, Mellado Peña, Maria José, additional, Jourdain, Gonzague, additional, Juliet, Katabalwa, additional, Jumpimai, Thidarat, additional, Junkaew, Raungwit, additional, Jupimai, Thidarat, additional, Kaahwa, Winfred, additional, Kabasonga, Mildred, additional, Kaboggoza, Olivia, additional, Kadhuba, Rose Jacqueline, additional, Kaewbundit, Ampika, additional, Kaewmamueng, Kanyanee, additional, Kafufu, Bosco, additional, Kakayi, Brenda, additional, Kamboua, Phakamas, additional, Kanjanavanit, Suparat, additional, Kasangaki, Gladys, additional, Kasipong, Naruporn, additional, Kasozi, Miriam, additional, Katemba, Chrispus, additional, Kekane, Nkata, additional, Keminyeto, Edridah, additional, Khamduang, Woottichai, additional, Khamjakkaew, Warunee, additional, Khamkon, Jiraporn, additional, Khannak, Sasipass, additional, Khatngam, Orapin, additional, Khayanchoomnoom, Tassawan, additional, Khumalo, Busi, additional, Khunene, Mirriam, additional, Khusuwan, Suwimon, additional, Kibalama, Phionah, additional, Kibenge, Robinah, additional, Kirabira, Anthony, additional, Kityo, Cissy M, additional, Kiyimba, Lameck, additional, Klinprung, Soraya, additional, Kobusingye, Olivia, additional, Kobusungye, Josephine, additional, Kongponoi, Areerat, additional, Königs, Christoph, additional, Koole, Olivier, additional, Kouakam, Christelle, additional, Krueduangkam, Nitinart, additional, Kruenual, Namthip, additional, Kunjaroenrut, Nuananong, additional, Kyambadde, Raymonds, additional, Kyobutungi, Priscilla, additional, Kyomuhendo, Flavia, additional, Kyomukama, Erinah, additional, Lakha, Reshma, additional, Langa, Cleopatra, additional, Laomanit, Laddawan, additional, Lebotsa, Emily, additional, Leenasirimakul, Prattana, additional, Lekku, Lawrence, additional, Lensen, Sarah, additional, Leroy, Valériane, additional, Li, Jin, additional, Limplertjareanwanich, Juthamas, additional, Little, Emma, additional, Lutalo, Ezra, additional, Jimenez, Jose Luis, additional, Lyall, Hermione, additional, MacDonald, Candice, additional, Machache, Gladness, additional, Madlala, Penelope, additional, Madonsela, Tryphina, additional, Maduna, Nomfundo, additional, Maena, Joel, additional, Mahanontharit, Apicha, additional, Makanga, Collin, additional, Makola, Candice, additional, Makumbi, Shafic, additional, Malgraaf, Lucille, additional, Mamiane, Angelous, additional, Mantkowski, Felicia, additional, Mapfumo, Wendy, additional, Marques, Laura, additional, Mugagga, Agnes Mary, additional, Maseko, Lindiwe, additional, Masienyane, Tshepiso, additional, Mathiba, Ruth, additional, Matimba, Farai, additional, Mawlana, Sajeeda, additional, Mayanja, Emmanuel, additional, Mayat, Fatima, additional, Mbabazi, Ritah, additional, Mbadaliga, Nokuthula, additional, Mbasani, Faith, additional, McClaughlin, Kathleen, additional, McIlleron, Helen, additional, Meethaisong, Watchara, additional, Mendez Garcia, Patricia, additional, Miwanda, Annet, additional, Miranda, Carlota, additional, Mkhize, Siphiwe, additional, Mmolawa, Kgosimang, additional, Mngqibisa, Rosie, additional, Mohamed, Fatima, additional, Monametsi, Maletsatsi, additional, Montero, Samuel, additional, Moore, Cecilia L, additional, Mosia, Rejoice, additional, Moyo, Columbus, additional, Mthethwa, Mumsy, additional, Mudzingwa, Shepherd, additional, Mudzviti, Tawona, additional, Mujuru, Hilda, additional, Mujyambere, Emmanuel, additional, Mukanganiki, Trust, additional, Mukisa Williams, Cynthia, additional, Mulder, Mark, additional, Mulima, Disan, additional, Mulindwa, Alice, additional, Mupambireyi, Zivai, additional, Murciano Cabeza, Alba, additional, Murungi, Herbert, additional, Murungu, Dorothy, additional, Musarurwa, Sandra, additional, Musiime, Victor, additional, Musiime, Alex V, additional, Musisi, Maria, additional, Musoke, Philippa, additional, Musoke Nakirya, Barbara, additional, Musoro, Godfrey, additional, Musumba, Sharif, additional, Mustafa, Sobia, additional, Mutsai, Shirley, additional, Mwesigwa Rubondo, Phyllis, additional, Naabalamba, Mariam, additional, Nagawa, Immaculate, additional, Naidoo, Allemah, additional, Nakabuye, Shamim, additional, Nakabuye, Sarah, additional, Nakalanzi, Sarah, additional, Nalubwama, Justine, additional, Nalugo, Annet, additional, Nalusiba, Stella, additional, Namajja, Clementine, additional, Namanda, Sylvia, additional, Namayanja, Paula, additional, Nambi, Esther, additional, Namuddu, Rachael Kikabi, additional, Namukwaya, Stella, additional, Namuli, Florence, additional, Namusanje, Josephine, additional, Namwanje, Rosemary, additional, Nanan-kanjee, Anusha, additional, Nanduudu, Annet, additional, Nankunda, Charity, additional, Baddokwaya, Joanita Nankya, additional, Nannungi, Maria, additional, Nansamba, Winnie, additional, Nanthapisal, Kesdao, additional, Nanyonjo, Juliet, additional, Nasaazi, Claire, additional, Nascimento, Helena, additional, Nastouli, Eleni, additional, Songtaweesin, Wipaporn Natalie, additional, Nathoo, Kusum, additional, Natuhurira, Ian, additional, Nazzinda, Rashidah, additional, Ncgaba, Thabisa, additional, Ndigendawani, Milly, additional, Ndlovu, Makhosonke, additional, Nentsa, Georgina, additional, Ngampiyaskul, Chaiwat, additional, Ngcobo, Ntombenhle, additional, Ngo Giang Huong, Nicole, additional, Ngwaru, Pia, additional, Nhema, Ruth, additional, Ninsiima, Emily, additional, Ninsiima, Gloria, additional, Nkalo Phiri, Misheck, additional, Noguera Julian, Antoni, additional, Nolan, Monica, additional, Noppakaorattanamanee, Thornthun, additional, Nsibuka Kisekka, Muzamil, additional, Nsirim, Eniola, additional, Nundlal, Rashina, additional, Nunes, Rosita, additional, Nyantsa, Lungile, additional, Nyati, Mandisa, additional, O'Riordan, Sean, additional, Ocitti Labeja, Paul, additional, Odoch, Denis, additional, Oguntimehin, Rachel, additional, Ojok, Martin, additional, Onen, Geoffrey, additional, Orange, Wilma, additional, Ounchanum, Pradthana, additional, Ouma, Benson, additional, Padrao, Andreia, additional, Pako, Deborah, additional, Parker, Anna, additional, Pasko-Szcech, Malgorzata, additional, Patel, Reena, additional, Peongjakta, Rukchanok, additional, Petpranee, Turian, additional, Phillips, Tasmin, additional, Philps, Jackie, additional, Picault, Laura, additional, Pieterse, Sonja, additional, Pinheiro, Helena, additional, Pongprapass, Supawadee, additional, Pozniak, Anton, additional, Prendergast, Andrew, additional, Prieto Tato, Luis, additional, Puangmalai, Patcharee, additional, Rakgokong, Modiehi, additional, Ramos, Helena, additional, Ramsagar, Nastassja, additional, Rau, Cornelius, additional, Riault, Yoann, additional, Rojo Conejo, Pablo, additional, Clark, Basiimwa Roy, additional, Rubanga, Eddie, additional, Rubinga, Baker, additional, Ruklao, Chutima, additional, Runarassamee, Pattira, additional, Saenjum, Chalermpong, additional, Saewtrakool, Chayakorn, additional, Saidi, Yacine, additional, Sainz Costa, Talia, additional, Saisaengjan, Chutima, additional, Sakwa, Rebecca, additional, Sarfati, Tatiana, additional, Sbisi, Noshalaza, additional, Scheppers, Dihedile, additional, Schultze-Strasser, Stephan, additional, Schulze-Sturm, Ulf, additional, Scott, Karen, additional, Seeley, Janet, additional, Serunjogi, Robert, additional, Sewnarain, Leora, additional, Shakeshaft, Clare, additional, Sidhoo, Subashinie, additional, Shibemba, Mercy, additional, Shingadia, Delane, additional, Singh, Sheleika, additional, Sirirungsi, Wasna, additional, Sithebe, Sibongile, additional, Smit, Theresa, additional, Smith, Kurt, additional, Smuts, Marlize, additional, Spyer, Moira, additional, Sripaoraya, Worathip, additional, Srisuk, Warunee, additional, Ssenyonga, Mark, additional, Sudsaard, Patamawadee, additional, Sukrakanchana, Praornsuda, additional, Tearsansern, Pathanee, additional, Teixeira, Carla, additional, Than-in-at, Kanchana, additional, Thapwai, Thitiwat, additional, Thaweesombat, Yupawan, additional, Thewsoongnoen, Jutarat, additional, Thiébaut, Rodolphe, additional, Thomason, Margaret, additional, Thrasyvoulou, Laura, additional, Thungkham, Khanungnit, additional, Tikabibamu, Judith, additional, Tinago, Gloria, additional, Trairat, Ketmookda, additional, Tudor-Williams, Gareth, additional, Tukamushaba, Mercy, additional, Tukwasibwe, Deogratiuos, additional, Tumusiime, Julius, additional, Tuna, Joana, additional, Turkova, Anna, additional, Turner, Rebecca, additional, Udomvised, Arttasid, additional, Vadee, Aasia, additional, Van Huyssteen, Hesti, additional, Van Looy, Nadine, additional, Variava, Ebrahim, additional, Vaughan-Gordon, Yvonne, additional, Vecchia, Giulio, additional, Vowden, Richard, additional, Waalewijn, Hylke, additional, Wampamba, Rebecca, additional, Welch, Steve, additional, Weller, Ian, additional, Weza, Sibusisiwe, additional, White, Ian, additional, Widuch, Kaja, additional, Wilkes, Helen, additional, Wimonklang, Sookpanee, additional, Wynne, Ben, additional, Yingyong, Pacharaporn, additional, Nakawungu, Zaam Zinda, additional, and Zuidewind, Peter, additional

Published
2023
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10. Viral Load suppression after intensive adherence counselling among HIV infected adults at Kiswa Health Centre, Kampala: A retrospective cohort study. Secondary data analysis

Author

Nakaye, Catherine, primary, Mukiza, Nelson, additional, Mawanda, Denis, additional, Kataike, Hajira, additional, Kaganzi, Hellen, additional, Ahimbisibwe, Grace Miriam, additional, Businge, Gerald Bright, additional, Kyambadde, Raymonds Crespo, additional, and Nakalega, Rita, additional

Published
2022
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11. Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial

Author

Turkova, Anna, primary, Waalewijn, Hylke, additional, Chan, Man K, additional, Bollen, Pauline D J, additional, Bwakura-Dangarembizi, Mutsa F, additional, Kekitiinwa, Adeodata R, additional, Cotton, Mark F, additional, Lugemwa, Abbas, additional, Variava, Ebrahim, additional, Ahimbisibwe, Grace Miriam, additional, Srirompotong, Ussanee, additional, Mumbiro, Vivian, additional, Amuge, Pauline, additional, Zuidewind, Peter, additional, Ali, Shabinah, additional, Kityo, Cissy M, additional, Archary, Moherndran, additional, Ferrand, Rashida A, additional, Violari, Avy, additional, Gibb, Diana M, additional, Burger, David M, additional, Ford, Deborah, additional, Colbers, Angela, additional, Mehar (nee Abdulla), Amina Farhana, additional, Abraham, Pattamukkil, additional, Abrams, Elaine, additional, Acero, Judith, additional, Agaba, Gerald Muzorah, additional, Ahimbisibwe, Grace, additional, Ainebyoona, Barbara, additional, Akobye, Winnie, additional, Akhalwaya, Yasmeen, additional, Akoojee, Nazim, additional, Ali, Shabinah S., additional, Andrea, Catherine, additional, Muñoz Fernandez, Maria Angeles, additional, Ankunda, Rogers, additional, Rutebarika, Diana Antonia, additional, Anugulruengkitt, Suvaporn, additional, Apollo, Tsitsi, additional, Arendze, Ronelle, additional, Ategeka, Juliet, additional, Atim, Eunice, additional, Atwine, Lorna, additional, Babiker, Abdel, additional, Babirye, Sarah, additional, Babu, Enock, additional, Bagirigomwa, Edward, additional, Baita, Angella, additional, Balamusani, David, additional, Baliram, Patsy, additional, Baliruno, David, additional, Ball, Colin, additional, Balwa, Henry, additional, Bamford, Alasdair, additional, Bandi, Srini, additional, Barker, Dominique, additional, Barlow-Mosha, Linda, additional, Bbuye, Dickson, additional, Begum, Shazia, additional, Behuhuma, Osee, additional, Bernays, Sarah, additional, Besigye, Rogers, additional, Bester, Maria, additional, Bhiri, Joyline, additional, Bilardi, Davide, additional, Bird, Kristien, additional, Bollen, Pauline, additional, Borg, Chiara, additional, Borges Da Silva, Anne-Marie, additional, Brown, Jackie, additional, Bruno, Elena, additional, Bunupuradah, Torsak, additional, Burger, David, additional, Buthelezi, Nomzamo, additional, Bwakura-Dangarembizi, Mutsa, additional, Byaruhanga, Africanus, additional, Calvert, Joanna, additional, Casey, Petronelle, additional, Cassim, Haseena, additional, Cebekhulu, Sphiwee, additional, Chailert, Sanuphong, additional, Chalermpantmetagul, Suwalai, additional, Chamjamrat, Wanna, additional, Chan, Man, additional, Chandiwana, Precious, additional, Chankun, Thannapat, additional, Chanthaburanun, Sararut, additional, Chanto, Nuttawut, additional, Chidziva, Ennie, additional, Chikowore, Minenhle, additional, Chimanzi, Joy, additional, Chinwong, Dujrudee, additional, Chitongo, Stuart, additional, Chitsamatanga, Moses, additional, Choga, Joshua, additional, Chutima, Duangrat, additional, Clayden, Polly, additional, Coelho, Alexandra, additional, Compagnucci, Alexandra, additional, Constança Mendes, Ana, additional, Conway, Magda, additional, Cotton, Mark F., additional, Crawley, Jane, additional, Cressey, Tim R., additional, Crisp, Jacky, additional, Matos, Ana Cristina, additional, Dadan, Sumaya, additional, Daglish, Jacqui, additional, Danaviah, Siva, additional, Daniel, Tseleng, additional, De Rossi, Anita, additional, Denjanta, Sukanda, additional, Dobbels, Els, additional, Dowie, Maria, additional, Dube, Prosper, additional, Dube, Benedictor, additional, Dudakia, Nimisha, additional, Elwana, Alice, additional, Epalza, Cristina, additional, Eram, David, additional, Erasmus, Juan, additional, Erim, Peter, additional, Escosa Garcia, Luis, additional, Essack, Zaakirah, additional, Estepa, Carolina, additional, Etima, Monica, additional, Fernandes, Alexandre, additional, Fernandez, Maite, additional, Fitzgerald, Felicity, additional, Flynn, Jacquie, additional, Fortuny Guasch, Claudia, additional, Foster, Caroline, additional, Fourie, George, additional, Fourie, Yolandie, additional, Foxall, Sophie, additional, Frank, Derusha, additional, Gandhi, Kate, additional, Garcia, India, additional, Gartner, Kathleen, additional, Gasa, Joshua, additional, Gasa, Gugu, additional, Giaquinto, Carlo, additional, Gibb, Diana M., additional, Gomez Rico, Coral, additional, Gomez-Pena, Daniel, additional, Gondo, Secrecy, additional, Goodman, Anna, additional, Gorreti Nakalema, Maria, additional, Gozhora, Winnie, additional, Greetanukroh, Pisut, additional, Gregorio Maranon, Biobanco, additional, Grossele, Tiziana, additional, Gwande, Shamiso, additional, Gwaze, Tapiwa, additional, Gwenzi, Tsitsi, additional, Hakim, James, additional, Hakiza, Emmanuel, additional, Kaka, Abdul Hamid, additional, Harley, Ashley, additional, Isaacs, Mornay, additional, Isabirye, Richard, additional, Ishemunyoro, Wilber, additional, Jacobs, Tom, additional, Jafta, Lungile, additional, Jamil, Nasir, additional, Janse van Rensburg, Anita Janse, additional, Jeaven, Vinesh, additional, Mellado Peña, Maria José, additional, Jourdain, Gonzague, additional, Juliet, Katabalwa, additional, Jumpimai, Thidarat, additional, Junkaew, Raungwit, additional, Jupimai, Thidarat, additional, Kaahwa, Winfred, additional, Kabasonga, Mildred, additional, Kaboggoza, Olivia, additional, Kadhuba, Rose Jacqueline, additional, Kaewbundit, Ampika, additional, Kaewmamueng, Kanyanee, additional, Kafufu, Bosco, additional, Kakayi, Brenda, additional, Kamboua, Phakamas, additional, Kanjanavanit, Suparat, additional, Kasangaki, Gladys, additional, Kasipong, Naruporn, additional, Kasozi, Miriam, additional, Kataike, Hajira, additional, Katemba, Chrispus, additional, Kaudha, Elizabeth, additional, Kekane, Nkata, additional, Kekitiinwa, Adeodata R., additional, Keminyeto, Edridah, additional, Khamduang, Woottichai, additional, Khamjakkaew, Warunee, additional, Khamkon, Jiraporn, additional, Khannak, Sasipass, additional, Khatngam, Orapin, additional, Khayanchoomnoom, Tassawan, additional, Khumalo, Busi, additional, Khunene, Mirriam, additional, Khusuwan, Suwimon, additional, Kibalama, Phionah, additional, Kibenge, Robinah, additional, Kirabira, Anthony, additional, Kityo, Cissy M., additional, Kiyimba, Lameck, additional, Klein, Nigel, additional, Klinprung, Soraya, additional, Kobbe, Robin, additional, Kobusingye, Olivia, additional, Kobusungye, Josephine, additional, Kongponoi, Areerat, additional, Königs, Christoph, additional, Koole, Olivier, additional, Kouakam, Christelle, additional, Krueduangkam, Nitinart, additional, Kruenual, Namthip, additional, Kunjaroenrut, Nuananong, additional, Kyambadde, Raymonds, additional, Kyobutungi, Priscilla, additional, Kyomuhendo, Flavia, additional, Kyomukama, Erinah, additional, Lakha, Reshma, additional, Langa, Cleopatra, additional, Laomanit, Laddawan, additional, Lebotsa, Emily, additional, Leenasirimakul, Prattana, additional, Lekku, Lawrence, additional, Lensen, Sarah, additional, Leroy, Valériane, additional, Li, Jin, additional, Liberty, Afaaf, additional, Limplertjareanwanich, Juthamas, additional, Little, Emma, additional, Lutalo, Ezra, additional, Jimenez, Jose Luis, additional, Lyall, Hermione, additional, MacDonald, Candice, additional, Machache, Gladness, additional, Madlala, Penelope, additional, Madonsela, Tryphina, additional, Maduna, Nomfundo, additional, Maena, Joel, additional, Mahanontharit, Apicha, additional, Makanga, Collin, additional, Makola, Candice, additional, Makumbi, Shafic, additional, Malgraaf, Lucille, additional, Mamiane, Angelous, additional, Mantkowski, Felicia, additional, Mapfumo, Wendy, additional, Marques, Laura, additional, Mugagga, Agnes Mary, additional, Maseko, Lindiwe, additional, Masienyane, Tshepiso, additional, Mathiba, Ruth, additional, Matimba, Farai, additional, Mawlana, Sajeeda, additional, Mayanja, Emmanuel, additional, Mayat, Fatima, additional, Mbabazi, Ritah, additional, Mbadaliga, Nokuthula, additional, Mbasani, Faith, additional, McClaughlin, Kathleen, additional, McIlleron, Helen, additional, Meethaisong, Watchara, additional, Mendez Garcia, Patricia, additional, Miwanda, Annet, additional, Miranda, Carlota, additional, Mkhize, Siphiwe, additional, Mmolawa, Kgosimang, additional, Mngqibisa, Rosie, additional, Mohamed, Fatima, additional, Moloantoa, Tumelo, additional, Monametsi, Maletsatsi, additional, Montero, Samuel, additional, Moore, Cecilia L., additional, Mosia, Rejoice, additional, Moyo, Columbus, additional, Mthethwa, Mumsy, additional, Mudzingwa, Shepherd, additional, Mudzviti, Tawona, additional, Mujuru, Hilda, additional, Mujyambere, Emmanuel, additional, Mukanganiki, Trust, additional, Mukisa Williams, Cynthia, additional, Mulder, Mark, additional, Mulima, Disan, additional, Mulindwa, Alice, additional, Mupambireyi, Zivai, additional, Murciano Cabeza, Alba, additional, Murungi, Herbert, additional, Murungu, Dorothy, additional, Musarurwa, Sandra, additional, Musiime, Victor, additional, Musiime, Alex V., additional, Musisi, Maria, additional, Musoke, Philippa, additional, Musoke Nakirya, Barbara, additional, Musoro, Godfrey, additional, Musumba, Sharif, additional, Mustafa, Sobia, additional, Mutsai, Shirley, additional, Mwesigwa Rubondo, Phyllis, additional, Naabalamba, Mariam, additional, Nagawa, Immaculate, additional, Naidoo, Allemah, additional, Nakabuye, Shamim, additional, Nakabuye, Sarah, additional, Nakalanzi, Sarah, additional, Nalubwama, Justine, additional, Nalugo, Annet, additional, Nalusiba, Stella, additional, Namajja, Clementine, additional, Namanda, Sylvia, additional, Namayanja, Paula, additional, Nambi, Esther, additional, Namuddu, Rachael Kikabi, additional, Namukwaya, Stella, additional, Namuli, Florence, additional, Namusanje, Josephine, additional, Namwanje, Rosemary, additional, Nanan-kanjee, Anusha, additional, Nanduudu, Annet, additional, Nankunda, Charity, additional, Baddokwaya, Joanita Nankya, additional, Nannungi, Maria, additional, Nansamba, Winnie, additional, Nanthapisal, Kesdao, additional, Nanyonjo, Juliet, additional, Na-Rajsima, Sathaporn, additional, Nasaazi, Claire, additional, Nascimento, Helena, additional, Nastouli, Eleni, additional, Songtaweesin, Wipaporn Natalie, additional, Nathoo, Kusum, additional, Natuhurira, Ian, additional, Nazzinda, Rashidah, additional, Ncgaba, Thabisa, additional, Ndigendawani, Milly, additional, Ndlovu, Makhosonke, additional, Nentsa, Georgina, additional, Ngampiyaskul, Chaiwat, additional, Ngcobo, Ntombenhle, additional, Ngo Giang Huong, Nicole, additional, Ngwaru, Pia, additional, Nhema, Ruth, additional, Ninsiima, Emily, additional, Ninsiima, Gloria, additional, Nkalo Phiri, Misheck, additional, Noguera Julian, Antoni, additional, Nolan, Monica, additional, Noppakaorattanamanee, Thornthun, additional, Nsibuka Kisekka, Muzamil, additional, Nsirim, Eniola, additional, Nundlal, Rashina, additional, Nunes, Rosita, additional, Nyantsa, Lungile, additional, Nyati, Mandisa, additional, O'Riordan, Sean, additional, Ocitti Labeja, Paul, additional, Odoch, Denis, additional, Oguntimehin, Rachel, additional, Ojok, Martin, additional, Onen, Geoffrey, additional, Orange, Wilma, additional, Ounchanum, Pradthana, additional, Ouma, Benson, additional, Padrao, Andreia, additional, Pako, Deborah, additional, Parker, Anna, additional, Pasko-Szcech, Malgorzata, additional, Patel, Reena, additional, Peongjakta, Rukchanok, additional, Petpranee, Turian, additional, Phillips, Tasmin, additional, Philps, Jackie, additional, Picault, Laura, additional, Pieterse, Sonja, additional, Pinheiro, Helena, additional, Pongprapass, Supawadee, additional, Pozniak, Anton, additional, Prendergast, Andrew, additional, Prieto Tato, Luis, additional, Puangmalai, Patcharee, additional, Puthanakit, Thanyawee, additional, Rakgokong, Modiehi, additional, Ramos, Helena, additional, Ramsagar, Nastassja, additional, Rau, Cornelius, additional, Riault, Yoann, additional, Rojo Conejo, Pablo, additional, Clark, Basiimwa Roy, additional, Rubanga, Eddie, additional, Rubinga, Baker, additional, Ruklao, Chutima, additional, Runarassamee, Pattira, additional, Saenjum, Chalermpong, additional, Saewtrakool, Chayakorn, additional, Saidi, Yacine, additional, Sainz Costa, Talia, additional, Saisaengjan, Chutima, additional, Sakwa, Rebecca, additional, Sarfati, Tatiana, additional, Sbisi, Noshalaza, additional, Scheppers, Dihedile, additional, Schultze-Strasser, Stephan, additional, Schulze-Sturm, Ulf, additional, Scott, Karen, additional, Seeley, Janet, additional, Serunjogi, Robert, additional, Sewnarain, Leora, additional, Shakeshaft, Clare, additional, Sidhoo, Subashinie, additional, Shibemba, Mercy, additional, Shingadia, Delane, additional, Singh, Sheleika, additional, Sirirungsi, Wasna, additional, Sithebe, Sibongile, additional, Smit, Theresa, additional, Smith, Kurt, additional, Smuts, Marlize, additional, Spyer, Moira, additional, Sripaoraya, Worathip, additional, Srisuk, Warunee, additional, Ssenyonga, Mark, additional, Sudsaard, Patamawadee, additional, Sukrakanchana, Praornsuda, additional, Tearsansern, Pathanee, additional, Teixeira, Carla, additional, Than-in-at, Kanchana, additional, Thapwai, Thitiwat, additional, Thaweesombat, Yupawan, additional, Thewsoongnoen, Jutarat, additional, Thiébaut, Rodolphe, additional, Thomason, Margaret, additional, Thrasyvoulou, Laura, additional, Thungkham, Khanungnit, additional, Tikabibamu, Judith, additional, Tinago, Gloria, additional, Trairat, Ketmookda, additional, Tudor-Williams, Gareth, additional, Tukamushaba, Mercy, additional, Tukwasibwe, Deogratiuos, additional, Tumusiime, Julius, additional, Tuna, Joana, additional, Turkova, Anna, additional, Turner, Rebecca, additional, Udomvised, Arttasid, additional, Vadee, Aasia, additional, Van Huyssteen, Hesti, additional, Van Looy, Nadine, additional, Vaughan-Gordon, Yvonne, additional, Vecchia, Giulio, additional, Vowden, Richard, additional, Wampamba, Rebecca, additional, Welch, Steve, additional, Weller, Ian, additional, Weza, Sibusisiwe, additional, White, Ellen, additional, White, Ian, additional, Widuch, Kaja, additional, Wilkes, Helen, additional, Wimonklang, Sookpanee, additional, Wynne, Ben, additional, Yingyong, Pacharaporn, additional, and Nakawungu, Zaam Zinda, additional

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2022
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