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The purpose of the work is to develop model characteristics of physical development, physical and technical preparedness of players of 15 years of different playing roles. Material and methods. Participants. In the study, 47 football players took part in 15 years of the Sports School "Areal" in Kharkov. Methods. Analysis of scientific and methodological literature, determination of physical development indicators testing of physical and technical preparedness, methods of mathematical statistics. The course of the study. The results of physical development, physical and technical preparedness of football players for 15 years are fixed. Model characteristics of physical and technical preparedness of young football players are developed. Analyzed comparative characteristics of the physical and technical preparedness of players 15 years of different playing roles. Results. It is established, according to the indicators of the physical development of players, players of different playing roles practically do not differ from each other. It is shown that the goalkeepers have practically the lowest technical and physical readiness indicators practically in all test results, in contrast to the attackers, defenders and midfielders. It is recommended that the development of a program for the development of physical qualities for goalkeepers, as well as the development of a separate program for improving the technical preparedness for players of each playing role. Conclusions. It is fixed, significant differences in the level of physical and technical preparedness between field players and goalkeepers. It is established that the greatest differences between representatives of different playing roles in terms of juggling, holding the ball on the foot, accuracy and range of strikes. It was revealed, not the reliability of the difference between the indicators of physical and technical preparedness of attackers, defenders and midfielders, which indicates their universality, and, therefore, possible replacement of each other.

Introduction: DEAH-box helicase 8 (DHX8) is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the splice. Here, we report the interaction study of human DHX8 and four test compounds namely etoposide, netropsin, nogalamycin, and novobiocin. Materials and Methods: Molecular docking and fluorescence emission spectra techniques were employed to determine the binding and inhibitory effect of test compounds. Results: Our docking and fluorescence emission spectra results showed that DHX8 has a good binding preference for novobiocin among these four test compounds. Moreover, fluorescence emission spectra of DHX8 with novobiocin also revealed the 2.5 µM concentration is an effective novobiocin concentration to inhibit the activity of DHX8. Conclusion: These findings provide an in-depth understanding of the inhibition of DHX8 and contribute insights towards the development of novobiocin as a therapeutic molecule against the DHX8 in targeted diseases. [ABSTRACT FROM AUTHOR]

Herein, the aggregation phenomena of the two cationic amphiphiles, the hexadecyltrimethylammonium bromide (CTAB), and tetradecyltrimethylammonium bromide (TTAB), has been investigated in the presence of monosaccharide (glucose) and disaccharide (maltose) at varying compositions and temperatures. The critical micelle concentration (cmc), degree of ionization (g), and several thermodynamic properties have been estimated applying the conductivity measurement technique. To explore the consequence of additives on the mixed micellization of TTAB + CTAB, glucose as monosaccharide having two concentrations (1% & 5% (w/w) glucose) and maltose as disaccharide containing single concentration (1% (w/w)) have been employed. Together with the mixture of TTAB and CTAB, investigation of the physicochemical parameters of pure amphiphiles in glucose and maltose solutions was quantified. The efficiency of the additives in depressing the cmc values followed the order: 1 (w/w) % maltose >5 (w/w) % glucose >1% (w/w) glucose. The ideal cmc (cmcid), activity coefficients, and β values suggested the synergistic attraction (attractive force) between these two surfactants. By utilizing the Rubingh model, the evaluated micellar mole fractions of CTAB (α1) coupled with the ideal mole fraction (X1id) imply the increase of the contribution of CTAB in the mixed micellization with rising the α1 values. The values of the negative excess free energy (ΔGexRub) implied the stability of the mixed micelle formed. The changes in standard enthalpy (ΔH°m) and changes in standard entropy (ΔS°m) of micellization reveal the presence of different modes of interactions like electrostatic, ion‐dipole, H‐bonding, and hydrophobic interactions among the studied components. [ABSTRACT FROM AUTHOR]

Human society or civilization is constantly faced with various tests. One such test is the COVID-19 pandemic, which is associated with the spread of a special type of coronavirus. Therefore, humanity is forced to find adequate measures to protect against the COVID-19 pandemic. For this purpose it is needed to know the reliable statistics. Additionally, it is important to know the features of the spread of COVID-19, to be able to make effective forecasts. This can be possible only by using various models. Different models take into account with specific features for the future prediction of the spread of the pandemic. These basic aspects are discussed in this work, which helps people for making better decisions for future strategies. [ABSTRACT FROM AUTHOR]

The pandemic COVID-19 is the most terrible calamity of the present human history also it has led to the worldwide issue of public health as a primary health safety problem. It was assumed that the infection of COVID-19 has two-phases, the immune protective as well as damaging phase. In the immune protective phase, clinicians try to enhance the patient immune response, and in the immune damaging phase, clinicians try to control the inflammatory immune response. Zinc belongs to the d-block or a transition element, it is an indispensable trace metal needed for vital cell activities like growth, as well as cell survival. It has significant contributions to immune homeostasis and functions; zinc inadequacy reduces primary and secondary immune responses equally. Studies have shown people who are deficient in zinc are more susceptible to infection. An inclusive knowledge of the bioavailability of the transition metal zinc will help to be aware of those that are valuable and protective for the population's health. This work is concentrated on the significance of zinc for the immune function, the presence of it's in optimum amounts and how it is beneficial to health in general and in fighting with COVID 19 in particular until today. [ABSTRACT FROM AUTHOR]

In this article, an attempt has been made review on phenolics antioxidant activity, and characteristics, as well as the constituents of the different phenolics present in various consumable food items, which reduce the risk of non-communicable diseases. Some polyphenolic compounds are present in selected species, which are beneficial to public health, and it should be comprised as component of food habits for a proper nutrition’s plan. Polyphenols are basically a natural compound and their micronutrients are found in different fruits, beverages, and vegetables. There is no specific deficiency disease caused due to the low dietary intake of phenolics; while the proper intake possibly gives health benefits. Polyphenols are antioxidants, and evidence for their role with improved heart health, neurodegenerative (Alzheimer’s disease) diseases, better blood sugar control, diabetes, reduced inflammation, and a reduced risk of cancer development was studied. A comprehensive understanding of the biological availability of the nutritional polyphenols will helpful to recognize those that are beneficial and protective for human health. Based on latest reports, polyphenolic compounds occupy a unique place in environmental science as an important and common class of bioactive natural products globally. It is building a bridge between different interdisciplinary academic fields of science. This work is based on the reports examined the health effect of polyphenols until today. [ABSTRACT FROM AUTHOR]

Image processing is one of the methods of analyzing and obtaining new information. Image processing methods can be applied to any image. Image processing is used in various fields of research. Among the stages of image processing, the stage of image pre-processing is important. This stage allows increasing the efficiency of the analysis of the original image. We considered the use of pre-processing for the analysis of natural polymer composites image. In this paper, we describe the possibilities of automatic processing of natural polymer composites image. [ABSTRACT FROM AUTHOR]